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3 results on '"RT, Radiation treatment"'

1. Immune checkpoint inhibitor therapy in HIV-associated Merkel cell carcinoma: A case series of 3 patients

Author

Michi M. Shinohara, Kelly G. Paulson, Paul Nghiem, Karl D. Lewis, Nora A. Alexander, Candice D. Church, Nancy S. Lee, and Song Youn Park

Subjects
MCPyV, Merkel cell polyomavirus, Immune checkpoint inhibitors, medicine.medical_treatment, MCC, Merkel cell carcinoma, Human immunodeficiency virus (HIV), Merkel cell polyomavirus, Case Report, aMCC, advanced Merkel cell carcinoma, Dermatology, medicine.disease_cause, PET, positron emission tomography, Merkel cell carcinoma, Acquired immunodeficiency syndrome (AIDS), PD-L1, PD-L1, anti-programmed death ligand-1, medicine, lcsh:Dermatology, MCC, biology, PD-1, anti-programmed cell death-1, business.industry, HIV, Immunotherapy, lcsh:RL1-803, RT, radiation treatment, biology.organism_classification, medicine.disease, AIDS, ICI, immune checkpoint inhibitors, CR, complete response, biology.protein, Cancer research, Immunohistochemistry, immunotherapy, business, IHC, immunohistochemistry, anti-PD-(L)1 agent
Published
2021

2. A case-control study of the joint effect of reproductive factors and radiation treatment for first breast cancer and risk of contralateral breast cancer in the WECARE study

Author

Meghan Woods, Rikke Langballe, Anne S. Reiner, S. A. Smith, Julia A. Knight, Patrick Concannon, Charles F. Lynch, Leslie Bernstein, Xiaolin Liang, Marc Tischkowitz, Jonine L. Bernstein, Esther M. John, Kathleen E. Malone, Lene Mellemkjær, Roy E. Shore, Daniel O. Stram, Jennifer D. Brooks, John D. Boice, Tischkowitz, Marc [0000-0002-7880-0628], and Apollo - University of Cambridge Repository

Subjects
Neoplasms, Radiation-Induced, RT, Radiation treatment, SEER, Surveillance Epidemiology and End Results, 0302 clinical medicine, Pregnancy, Risk Factors, Epidemiology, UBC, Unilateral breast cancer, 030212 general & internal medicine, Breast, education.field_of_study, Reproductive Physiological Phenomena, Obstetrics, Neoplasms, Second Primary, General Medicine, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, WECARE Study, Parity, 030220 oncology & carcinogenesis, Original Article, Female, RR, Rate ratio, Adult, medicine.medical_specialty, Population, Breast Neoplasms, lcsh:RC254-282, 03 medical and health sciences, Breast cancer, NCI, National Cancer Institute, Statistical significance, parasitic diseases, medicine, Humans, education, Reproductive factors, Aged, Gy, Gray, business.industry, CI, Confidence interval, Case-control study, Cancer, WECARE, Women’s Environmental Cancer and Radiation Epidemiology, Radiation treatment, medicine.disease, Confidence interval, Logistic Models, Contralateral breast cancer, Case-Control Studies, Surgery, CBC, Contralateral breast cancer, business
Abstract

Objective To examined the impact of reproductive factors on the relationship between radiation treatment (RT) for a first breast cancer and risk of contralateral breast cancer (CBC). Methods The Women’s Environmental Cancer and Radiation Epidemiology (WECARE) Study is a multi-center, population-based case-control study where cases are women with asynchronous CBC (N = 1521) and controls are women with unilateral breast cancer (N = 2211). Rate ratios (RR) and 95% confidence intervals (CI) were estimated using conditional logistic regression to assess the independent and joint effects of RT (ever/never and location-specific stray radiation dose to the contralateral breast [0, >0, Highlights • Radiation treatment is associated with increased contralateral breast cancer risk in some women. • Reproductive status at the time of treatment may modify this relationship. • Some evidence that pregnancy after radiation treatment increases contralateral breast cancer risk.

Published
2020
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3. Immune checkpoint inhibitor therapy in HIV-associated Merkel cell carcinoma: A case series of 3 patients.

Author

Park SY, Church C, Alexander NA, Shinohara MM, Paulson KG, Lewis KD, Lee NS, and Nghiem P

Abstract

Competing Interests: Dr Nghiem has received consulting fees from 10.13039/100004755EMD Serono, 10.13039/100004319Pfizer, 10.13039/100004339Sanofi/10.13039/100009857Regeneron, and 4SC and research grant support from Bristol-Meyers Squibb. Dr Paulson has received research grant support from 10.13039/100004755EMD Serono, Bluebird Biosciences, and 10.13039/100004334Merck. Dr Lewis has received consulting fees from 10.13039/100004334Merck and 10.13039/100009857Regeneron and research grant support from Bristol-Meyers Squibb, 10.13039/100004334Merck, 10.13039/100009857Regeneron, and 10.13039/100004755EMD Serono. Author Alexander and Drs Park, Church, Shinohara, Lewis, and Lee have no conflicts of interest to declare.

Published
2020
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