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IntroductionPsoriasis is a chronic disease involving the skin, which significantly impacts the quality of life. Disease severity and treatment efficacy (i.e., response) are assessed through the Psoriasis Area and Severity Index (PASI). A PASI 75 response, i.e., an improvement of at least 75% with respect to the baseline PASI score, has traditionally been used as a therapeutic benchmark in clinical trials. Therapeutic advances have made PASI 90 or PASI 100 responses possible in most patients treated with some biologics. A greater response may generate social value beyond clinical outcomes that would benefit both patients and society.MethodsA 1-year economic model was applied to estimate the impact of having a PASI 75, PASI 90, or PASI 100 response in four areas of analysis (quality of life, activities of daily living, work productivity, and out-of-pocket expenditures) and the social value of having a PASI 90 or PASI 100 response in comparison with a PASI 75 response. A mixed-methods approach based on the scientific literature, a focus group with patient, and an advisory committee with psoriasis stakeholders was used. The model included three different scenarios: having a PASI 90 vs a PASI 75 response; a PASI 100 vs a PASI 90 response; and a PASI 100 vs a PASI 75 response. A sensitivity analysis was included.ResultsThe annual economic impact per patient with moderate-to-severe plaque psoriasis having a PASI 75 response was estimated at Ł 6,139, mainly related to labour productivity losses and quality of life reductions. Having a PASI 90 or a PASI 100 response would reduce this impact to €3,956 or €1,353, respectively. Accordingly, the social value of having a PASI 90 instead of a PASI 75 response was estimated at €2,183, and €4,786 with a PASI 100 response.DiscussionA PASI 90 or PASI 100 response would have a lower economic impact and a greater social value than a PASI 75 response for patients with moderate-to-severe plaque psoriasis.

[Esp]En el presente Trabajo de Fin de Grado estudiaremos las obligaciones de información tributaria, su regulación, modos o cauces de obtención, así como los obligados a suministrar la información. Una vez abordadas todas las cuestiones relativas a las obligaciones o deberes de información, pasaremos a estudiar los límites, tanto constitucionales como contenidos en normas con rango ley, que acotan la facultad de obtención de información por parte de la Administración. Para finalizar, acabaremos indagando, por el interés de nuestro trabajo, en un límite constitucional en particular, el derecho a la intimidad, observando hasta qué punto las obligaciones de información pueden llegar a interferir en la esfera íntima de la vida privada de los ciudadanos. [Eng]n this Final Degree Project we will study the obligations of tax information, its regulation, modes or methods of obtaining it, as well as those obliged to provide the information. Once all the issues related to the obligations or duties of information have been addressed, we will go on to study the limits, both constitutional and contained in regulations with the rank of law, which limit the power of the Administration to obtain information. Finally, due to the interest of our work, we will end by investigating a particular constitutional limit, the right to privacy, observing to what extent information obligations may interfere in the intimate sphere of the private life of citizens Facultad de Ciencias de la Empresa Universidad Politécnica de Cartagena

Psoriasis is a frequent inflammatory disease with a chronic and relapsing course. Therefore, patients with psoriasis are likely to undergo different treatments for long periods of time. Traditionally, therapies used in psoriasis have been associated with poor levels of adherence due to the complexity of the regimens and the poor results obtained with the topical therapies. These poor outcomes are associated with high levels of frustration and anxiety, which decrease adherence and worsen the disease. With the recent introduction of highly efficacious biologic therapies, patients can achieve very good and prolonged responses. However, most patients with psoriasis have mild disease and may be treated with skin-directed therapies. Therefore, it is important to develop strategies to improve adherence in order to achieve better outcomes, and to improve the overall quality of life. Hence, acknowledging the causes of nonadherence is crucial for implementing these strategies. In this summary, we review the causes of nonadherence, and we provide behavioral strategies in order to improve adherence and, ultimately, the outcome of patients with psoriasis.

Oriol Yélamos, Sandra Ros, Lluís Puig Department of Dermatology, Hospital de la Santa Creu i Sant Pau – Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain Abstract: Psoriasis is a frequent inflammatory disease with a chronic and relapsing course. Therefore, patients with psoriasis are likely to undergo different treatments for long periods of time. Traditionally, therapies used in psoriasis have been associated with poor levels of adherence due to the complexity of the regimens and the poor results obtained with the topical therapies. These poor outcomes are associated with high levels of frustration and anxiety, which decrease adherence and worsen the disease. With the recent introduction of highly efficacious biologic therapies, patients can achieve very good and prolonged responses. However, most patients with psoriasis have mild disease and may be treated with skin-directed therapies. Therefore, it is important to develop strategies to improve adherence in order to achieve better outcomes, and to improve the overall quality of life. Hence, acknowledging the causes of nonadherence is crucial for implementing these strategies. In this summary, we review the causes of nonadherence, and we provide behavioral strategies in order to improve adherence and, ultimately, the outcome of patients with psoriasis. Keywords: psoriasis, adherence, outcome, drug therapy, psychotherapy

[ANGLÈS] The purpose of this Final Project is to justify the knowledge that I have acquired during the different periods of my career. It conveys the expertise and education obtained during my Degree in Technical Architecture, its development during a post degree in Science and Technology Edification and also an ulterior real-scale project in which I took part as a member of both the university's management team and an architectural firm's team. The aim is to expose all the improvements and editings needed during the phases of projection and construction of a specific building. This building in particular has previously been erected following the standards of a distinct type of construction. Due to a change of property, work has been discontinued with only the foundations put together. At this point a new project manager and a new director took over the project. Not only did they increase of the size of the building but also they did change the structure system and the interior's layout from the original project. The construction plan is for a four storey semi-detached building with ground floor. The ground floor consists in an empty room with no stablished purpose. The above four storeys are meant to be 6 apartments. Despite the fact of the reduced size of these apartments they are all under the current housing regulation. The building will also have a walking rooftop where the necessary installations will put into place. The methodology followed to carry out what I define as “Project of amendment and extension of a multifamily building located in Manresa's old town” will follow several format guidelines with two distinguished parts. First part concerns the academic work and the second part concerns he working project. From the field data base obtained from the foundations we will determine a new type of structure and architecture for the building. We will calculate the strength of the new structure using the program SAP 2000. The program will create a three dimensional model where will be able to add the architectural model of the existent foundation. We will also get dimensions of the structural sections using the Prontuari informàtic de la EHE. In relation to the general installations (pipelines, drainage, solar panels...) we will follow the legislation stablished prior to the application of the Technical Building Code. This is due to the request of the building permit which is prior to the start of its application. Therefore, we find ourselves in-between periods where the only necessary request is the fulfilment of the solar energy's bylaw. We will explain the constructive systems used and finally, we will expose the reasons why we have made such changes. These changes will result in the creation of a building with an unusual living space for the use of mobile partition walls. Once the project is finished we can conclude that with a change in the materials, a minimum space to live in and the integration of unconventional techniques of distribution we can achieve to lower the cost of the construction and also increase both well-being and the profitability of small spaces.