1. Burkitt t(8;14)(q24;q32) and cryptic deletion in a CLL patient: report of a case and review of literature
- Author
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Radha Satyadev, Kavita S. Reddy, Romero Paolo, Derek Bouman, Michele K. Hibbard, and Gary Lu
- Subjects
Male ,Cancer Research ,Derivative chromosome ,Chronic lymphocytic leukemia ,Genes, myc ,Chromosomal translocation ,CD38 ,Translocation, Genetic ,CD19 ,immune system diseases ,hemic and lymphatic diseases ,Genetics ,medicine ,Humans ,Molecular Biology ,In Situ Hybridization, Fluorescence ,Chromosomes, Human, Pair 14 ,CD20 ,biology ,Middle Aged ,medicine.disease ,Burkitt Lymphoma ,Leukemia, Lymphocytic, Chronic, B-Cell ,Molecular biology ,Leukemia ,Splenectomy ,biology.protein ,Chromosome Deletion ,CD5 ,Immunoglobulin Heavy Chains ,Chromosomes, Human, Pair 8 - Abstract
A 53-year-old man diagnosed with chronic lymphocytic leukemia (CLL)-small lymphoma following splenectomy was found to have a t(8;14) with an apparent cryptic deletion of the MYC gene. This patient's spleen and bone marrow (BM) showed that 93% and approximately 70% of the viable cells, respectively, were lambda-monoclonal B-cells coexpressing CD5 with CD20, CD19, CD23, CD22, CD38, and low FMC-7. The smear showed a marked increase in small, mature lymphoid cells, with
- Published
- 2006