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1,291 results on '"ROGERS, STEPHEN"'

1. Global perspectives and transdisciplinary opportunities for locust and grasshopper pest management and research

Author

Word Ries, Mira, Adriaansen, Chris, Aldobai, Shoki, Berry, Kevin, Bal, Amadou Bocar, Catenaccio, Maria Cecilia, Cigliano, María Marta, Cullen, Darron A., Deveson, Ted, Diongue, Aliou, Foquet, Bert, Hadrich, Joleen, Hunter, David, Johnson, Dan L., Pablo Karnatz, Juan, Lange, Carlos Ernesto, Lawton, Douglas, Lazar, Mohammed, Latchininsky, Alexandre V., Lecoq, Michel, Le Gall, Marion, Lockwood, Jeffrey, Manneh, Balanding, Overson, Rick, Peterson, Brittany F., Piou, Cyril, Poot-Pech, Mario A., Robinson, Brian E., Rogers, Stephen M., Song, Hojun, Springate, Simon, Therville, Clara, Trumper, Eduardo, Waters, Cathy, Woller, Derek A., Youngblood, Jacob P., Zhang, Long, Cease, Arianne, and Pensoft Publishers

Subjects
Acrididae, basic and applied research, biocontrol agents, collective action, environmental governance, food security, Global Locust Initiative (GLI), livelihoods, Locusta, Melanoplus, Metarhizium, multidisciplinary research, Oedaleus, Organizations, Orthoptera, Paranosema, Schistocerca, social-ecological-technological system (SETS), transboundary migratory pest
Published
2024

3. Addressing adverse social determinants of health in pediatric primary care: Study protocol for a hybrid type 2 effectiveness-implementation randomized controlled trial in two national pediatric practice-based research networks

Author

Brochier, Annelise, Torres, Alessandra, Tyrrell, Hollyce, Paz, Katherine Barahona, Wexler, Mikayla Gordon, Griffith, Miranda, Joiner, Terence, Magardino, Angela, Messmer, Emily, Rogers, Stephen, Scheindlin, Benjamin, Serwint, Janet R., Sharif, Iman, Shone, Laura P., Stockwell, Melissa S., Tripodis, Yorghos, Garg, Arvin, and Drainoni, Mari-Lynn

Published
2024
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6. Quasi-static Modeling of Feeding Behavior in Aplysia Californica

Author

Kundu, Bidisha, Rogers, Stephen M., Sutton, Gregory P., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Hunt, Alexander, editor, Vouloutsi, Vasiliki, editor, Moses, Kenneth, editor, Quinn, Roger, editor, Mura, Anna, editor, Prescott, Tony, editor, and Verschure, Paul F. M. J., editor

Published
2022
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7. Erythromer (EM), a Nanoscale Bio-Synthetic Artificial Red Cell

Author

Mittal, Nivesh, Rogers, Stephen, Dougherty, Shannon, Wang, Qihong, Moitra, Parikshit, Brummet, Mary, Cornett, Elyse M., Kaye, Alan D., Shekoohi, Sahar, Buehler, Paul, Spinella, Philip, Pan, Dipanjan, Doctor, Allan, Liu, Henry, editor, Kaye, Alan D., editor, and Jahr, Jonathan S., editor

Published
2022
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9. Molecular and morphological characterization of Tylenchus zeae n. sp. (Nematoda: Tylenchida) from Corn (Zea mays) in South Carolina

Author

Kantor Mihail R., Handoo Zafar A., Subbotin Sergei A., Mowery Joseph D., Hult Maria N., Rogers Stephen, and Skantar Andrea M.

Subjects
18s, 28s, coi, corn, dna sequencing, molecular phylogeny, morphology, nematode, new species, taxonomy, tylenchus zeae n. sp., Biology (General), QH301-705.5
Abstract

Specimens of a tylenchid nematode were recovered in 2019 from soil samples collected from a corn field, located in Pickens County, South Carolina, USA. A moderate number of Tylenchus sp. adults (females and males) were recovered. Extracted nematodes were examined morphologically and molecularly for species identification, which indicated that the specimens of the tylenchid adults were a new species, described herein as Tylenchus zeae n. sp. Morphological examination and the morphometric details of the specimens were very close to the original descriptions of Tylenchus sherianus and T. rex. However, females of the new species can be differentiated from these species by body shape and length, shape of excretory duct, distance between anterior end and esophageal intestinal valve, and a few other characteristics given in the diagnosis. Males of the new species can be differentiated from the two closely related species by tail, spicules, and gubernaculum length. Cryo-scanning electron microscopy confirmed head bearing five or six annules; four to six cephalic sensilla represented by small pits at the rounded corners of the labial plate; a small, round oral plate; and a large, pit-like amphidial opening confined to the labial plate and extending three to four annules beyond it. Phylogenetic analysis of 18S rRNA gene sequences placed Tylenchus zeae n. sp. in a clade with Tylenchus arcuatus and several Filenchus spp., and the mitochondrial cytochrome oxidase c subunit 1 (COI) gene region separated the new species from T. arcuatus and other tylenchid species. In the 28S tree, T. zeae n. sp. showed a high level of sequence divergence and was positioned outside of the main Tylenchus-Filenchus clade.

Published
2023
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16. Fludarabine, Cytarabine, Granulocyte Colony-Stimulating Factor, and Idarubicin With Gemtuzumab Ozogamicin Improves Event-Free Survival in Younger Patients With Newly Diagnosed AML and Overall Survival in Patients With NPM1 and FLT3 Mutations

Author

Russell, Nigel H., primary, Wilhelm-Benartzi, Charlotte, additional, Othman, Jad, additional, Dillon, Richard, additional, Knapper, Steven, additional, Batten, Leona M., additional, Canham, Joanna, additional, Hinson, Emily L., additional, Betteridge, Sophie, additional, Overgaard, Ulrik Malthe, additional, Gilkes, Amanda, additional, Potter, Nicola, additional, Mehta, Priyanka, additional, Kottaridis, Panagiotis, additional, Cavenagh, Jamie, additional, Hemmaway, Claire, additional, Arnold, Claire, additional, Freeman, Sylvie D., additional, Dennis, Mike, additional, Kallenbach, Maria, additional, Severinsen, Marianne, additional, Holm, Mette, additional, Maxwell Norgaard, Jan, additional, Beier Ommen, Hans, additional, Culligan, Dominic, additional, Tighe, Jane, additional, Craig, Jenny, additional, Crawley, Charles, additional, Krishnamurthy, Pramila, additional, Sadik, Walid, additional, Smith, Jeffery, additional, Dasgupta, Ranjit, additional, Berkhan, Leanne, additional, Bowett, Peter, additional, Doocey, Richard, additional, Emmett, Shannon, additional, Hawkins, Timothy, additional, Patton, Nigel, additional, Pemberton, Lucy, additional, Milne, Alison, additional, Roy, Ashok, additional, Simpson, Sylwia, additional, Cuthbert, Robert, additional, Finnegan, Damian, additional, Francis McMullin, Mary, additional, Pechey, Victoria, additional, Lovell, Richard, additional, Milligan, Donald, additional, Paneesha, Shankara, additional, Cahalin, Paul, additional, Kelsey, P., additional, Ackroyd, Sam, additional, Wiliams, Adrian, additional, Evely, Roger, additional, Marks, David, additional, Fletcher, Andrew, additional, Al-Ani, Maryam, additional, Ahmed, Khalil, additional, Lush, Richard, additional, Rye, Adam, additional, Cutting, Robert, additional, Welch, Emma, additional, Wodzinski, Mark, additional, Butler, Andrew, additional, Fernyhough, Liam, additional, Ganly, Peter, additional, Gibbons, Steve, additional, Smith, Mark, additional, Spearing, Ruth, additional, Peniket, Andy, additional, Hatcliffe, Faye, additional, Patel, Amit, additional, Lindsay, Kathrine, additional, Brearton, Gillian, additional, Tuegar, Salah, additional, Gandhi Anna Cowley, S., additional, Copplestone, Adrian, additional, Hunter, Hannah, additional, Medd, Patrick, additional, Nokes, Tim, additional, Rule, Simon, additional, Thomas, Wayne, additional, Joseph, Joe, additional, Kaul, Stuti, additional, Sorour, Youssef, additional, Chvuka, Shingi, additional, Mangos, Hilda, additional, Neylon, Annette, additional, Farrell, Katrina, additional, Edwards, Hugh, additional, Hanlon, Katharine, additional, Fail, Tom, additional, Goodrick, Margaret, additional, Heartin, Earnest, additional, Hoyle, Christine, additional, Carr, Robert, additional, Raj, Kavita, additional, Krogh Jensen, Morten, additional, Janmohamed, Riaz, additional, Kaczmarski, Richard, additional, Sugai, Taku, additional, Ademokun, Debo, additional, Chalmers, Isobel, additional, Hodson, Andrew, additional, Gomez, Cesar, additional, Sadullah, Shala, additional, Kwan, Mark, additional, Longmuir, Karyn, additional, Wilson-Morkeh, Isaac, additional, Hunter, Ann, additional, Martin, Murray, additional, Saravanamuttu, Kandeepan, additional, Sidra, Gamal, additional, Burns, Sarah, additional, Gibbs, Simon, additional, Tholouli, Eleni, additional, Aldouri, Maadh, additional, Andrews, Vivienne, additional, Eden, Ayed, additional, Dungarwalla, Moez, additional, White, Denise, additional, Laird, Jane, additional, Mitchell, Lindsey, additional, Murphy, John, additional, Paterson, Pamela, additional, Raafat, Alaeddin, additional, Mannari, Deepak, additional, Davies, Simon, additional, Austen, Belinda, additional, Allford, Sarah, additional, Kakalamudi, Sudhakar, additional, Basu, Supratik, additional, Hada, Sunil, additional, Jacob, Abraham, additional, MacWhonell, Alan, additional, McCaig, Alison, additional, Gelly, Keith, additional, Kerr, Ron, additional, Meiklejohn, David, additional, Tauro, Sudhir, additional, Lawes, Matthew, additional, Bowen, Angela, additional, Krishnamurthy, Suchitra, additional, Byrne, Jenny, additional, Dasgupta, Emma, additional, Russell, Nigel, additional, Stokley, Simone, additional, Friis, Lone, additional, Marcher, Claus, additional, Bake, Bart, additional, Chapple, Mary, additional, Moreton, Paul, additional, Omran, Asad, additional, Patil, Kavita, additional, Wright, David, additional, Jack, Fergus, additional, Maddams, Rebecca, additional, Corser, Robert, additional, Cranfield, Tanya, additional, Dignum, Helen, additional, Ganczakowski, Mary, additional, Jones, Christopher, additional, Craddock, Charles, additional, Moss, Paula, additional, Murray, Jim, additional, Craig, Joanne, additional, Forsyth, Peter, additional, Lush, Chris, additional, Wei Bjerrum, Ole, additional, Borregaard, Niels, additional, Kampmann, Peter, additional, Kjeldsen, Lars, additional, Juul Nielsen, Ove, additional, Niemann, Carsten, additional, Lykke Petersen, Soeren, additional, Udby Peter Møller, Lene, additional, Alfred, Arun, additional, Barker, Helen, additional, Went, Richard, additional, Groch, Henri, additional, Mucklow, Stuart, additional, Sampson, Rebecca, additional, Chacko, Joseph, additional, Hall, Rachel, additional, Walewska, Renata, additional, Creach, Desmond, additional, Pottinger, Bryson, additional, Addada, Juanah (Jo), additional, Hamilton, Malcolm, additional, Kerr, Paul, additional, Ngu, Loretta, additional, Rudin, Claudius, additional, Ruell, Jackie, additional, Dalley, Chris, additional, Kaur, Harpreet, additional, Reilly, John, additional, Snowden, John, additional, Ferguson, Paul, additional, Dyer, Peter, additional, Chandra, Deepak, additional, DeVos, Johannes, additional, Grey-Davies, Elisabeth, additional, Hendry, Louise, additional, Corbett, Timothy, additional, Crowe, Josephine, additional, Knechtli, Christopher, additional, Wexler, Sarah, additional, Fernandes, Savio, additional, Neilson, Jeff, additional, Houghton, John, additional, Jowitt, Simon, additional, Thomas-Dewing, Rowena, additional, Williams, Mark, additional, Zaman, Sonya, additional, Cullis, Jonathan, additional, Everington, Tamara, additional, Grand, Effie, additional, Hasan, Yasmin, additional, Murrin, Richard, additional, Wandoo, Farooq, additional, Ismail, Saad, additional, Mohite, Unmesh, additional, Sati, Hamdi, additional, Jenner, Matthew, additional, Orchard, Kim, additional, Richardson, Deborah, additional, McCloskey, Kayleigh, additional, Xu Chin, Kate, additional, Fenella Willis, Neoh, additional, Sud, Amit, additional, Gharib, Maged, additional, Nicholson, Toby, additional, Bowen, David, additional, Janes, Sarah, additional, Eagleton, Helen, additional, O'Hea, Anne-Marie, additional, Pattinson, Jonathan, additional, Hervey, Victoria, additional, Lyons, Simon, additional, Marshall, Scott, additional, Nicolle, Annette, additional, Vavyla, Maria, additional, Burgess, Jordan, additional, Somervaille, Tim, additional, Somerfield, Sven, additional, Mamat, Mohd, additional, Tomlins, Jo, additional, Salesh, Sana, additional, David, Marianna, additional, Maddox, Jamie, additional, Plews, Diane, additional, Dang, Ray, additional, Potter, Mike, additional, Ellis, Lauren, additional, Nicholson, Emma, additional, Keat, Sally, additional, Ahmed Alhassani, Thubeena M., additional, Anjum, Farahn, additional, Chatterjee, Poulami, additional, Stanchev, Atanas, additional, Peters, Jayne, additional, Lindsay-Holmes Srividhya, Sarah, additional, Chodhouri, Senthil S., additional, Eve, Heather, additional, Smith, Steve, additional, Roberts, Patrick, additional, Rymes, Nicholas, additional, Zhao New Oo, Rui, additional, Ardeshna, Kirit, additional, Blombery, Piers, additional, Khwaja, Asim, additional, Linch, David, additional, Popat, Rakesh, additional, Virchis, Andres, additional, Yong, Kwee, additional, McIntyre, Victoria, additional, Horne, Gillian, additional, Bokhari, Syed, additional, Borg, Anton, additional, Chapman, Oliver, additional, Harrison, Beth, additional, Jackson, Nicholas, additional, Jobanputra, Shailesh, additional, Narayanan, Mekkali, additional, Rose, Peter, additional, Oun, Hajer, additional, Powell, Matthew, additional, Gilles, Julie, additional, Laing, Alison, additional, Devanny, Ian, additional, Haskins, Lea, additional, Micallef-Eynaud, Paul, additional, Maclean, Peter, additional, Alvares, Caroline, additional, Kell, Jonathan, additional, Knapper, Steve, additional, Davidson, Kerri, additional, McLintock, Lorna, additional, Rogers, Stephen, additional, Williamson, Peter, additional, Corbett, Gillian, additional, Goodman, Hugh, additional, Islam, Shahid, additional, Pullon, Humphrey, additional, Johnson, Peter, additional, Roddie, P.H., additional, Maughan, Elizabeth, additional, Mills, Juliet, additional, Shafeek, Salim, additional, Narat, Santosh, additional, Aitchison, Robin, additional, Bond, Lee, additional, Munro, Laura, additional, and Edwards, David, additional

Published
2024
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23. An investigation into New Labour education policy : personalisation, young people, schools and modernity

Author

Rogers, Stephen Howard, Dyson, Alan, and Gunter, Helen

Subjects
353.8, Personalisation, personalised learning, personalising learning, New Labour, education policy, Alasdair MacIntyre, governance
Abstract

The New Labour government’s (1997-2010) policy of personalised learning was announced as an idea ‘exciting’ the profession and promising ‘radical implications’ for the shape of education in England. The policy attracted much debate and criticism and its enactment is a site worthy of research. This study makes a contribution to knowledge through researching the rarely heard stories of young people in this policy enactment. It makes a further contribution to policy scholarship through the interplay of the data from school practices and moral philosophy drawn from Alasdair MacIntyre.Qualitative interviews and focus group activities were conducted with young people in three different secondary schools in order to understand their stories of personalised learning some two years into New Labour’s third term of government. To understand more of the context for the stories of the young people, some strategic actors in policy dissemination were interviewed, as were the headteachers of the three schools.Personalised learning promised to engage the voice of the learner in learning practices. The research finds a young peoples’ story that is consistently one of a mute and invisible identity within the schools. An argument is presented that the purposes of schools ought to be judged on standards of excellence definitive of, and extended by, a concept of virtues. A distinction is made between effectiveness in producing exam results and a richer sense of excellence in education practice. It is argued that virtues that define standards of excellence at the institutional level of practice can enrich and prefigure wider concepts of justice than are contained in policy. Young peoples’ stories in this research indicate that, contrary to policy ideals, they often perceived unfairness and arbitrariness in their school experiences. Personalised learning needs to be set within the narrative of the personalisation of public services: a reforming rubric, employing the motif of the citizen-consumer as a proposition about social justice and modernisation. New Labour’s ideology and models of governance are explored and related to the testimony of headteachers to understand more about the young peoples’ perceptions. Literatures are drawn upon to place personalisation in a historical context, linking it to moral orders of contemporary social imaginaries. New Labour made a case for personalised learning as furthering the cause of social justice and is thus a policy in need of ethical examination. Following MacIntyre, it is argued that modernity has left few moral resources by which to evaluate the personal, but the experiences of young people suggested that a richer moral agency is glimpsed within their stories of schooling. The social practice at the level of schools is thus critical but requires policy to enable ethical spaces for schools to re-invigorate their purposes. I argue that in the light of some critical fault lines, such as neoliberalism and a reconfiguration of tiers of local governance, personalisation as a ‘modernising’ policy proposition could do little to extend the goods of schooling beyond some narrow conceptions of effectiveness.

Published
2012

24. Single unpurified breast tumor-initiating cells from multiple mouse models efficiently elicit tumors in immune-competent hosts.

Author

Kurpios, Natasza A, Girgis-Gabardo, Adele, Hallett, Robin M, Rogers, Stephen, Gludish, David W, Kockeritz, Lisa, Woodgett, James, Cardiff, Robert, and Hassell, John A

Subjects
Tumor Cells, Cultured, Animals, Mice, Transgenic, Mice, Mammary Neoplasms, Experimental, Transplantation, Homologous, Neoplasm Transplantation, Female, Mammary Neoplasms, Experimental, Transgenic, Transplantation, Homologous, Tumor Cells, Cultured, General Science & Technology
Abstract

The tumor-initiating cell (TIC) frequency of bulk tumor cell populations is one of the criteria used to distinguish malignancies that follow the cancer stem cell model from those that do not. However, tumor-initiating cell frequencies may be influenced by experimental conditions and the extent to which tumors have progressed, parameters that are not always addressed in studies of these cells. We employed limiting dilution cell transplantation of minimally manipulated tumor cells from mammary tumors of several transgenic mouse models to determine their tumor-initiating cell frequency. We determined whether the tumors that formed following tumor cell transplantation phenocopied the primary tumors from which they were isolated and whether they could be serially transplanted. Finally we investigated whether propagating primary tumor cells in different tissue culture conditions affected their resident tumor-initiating cell frequency. We found that tumor-initiating cells comprised between 15% and 50% of the bulk tumor cell population in multiple independent mammary tumors from three different transgenic mouse models of breast cancer. Culture of primary mammary tumor cells in chemically-defined, serum-free medium as non-adherent tumorspheres preserved TIC frequency to levels similar to that of the primary tumors from which they were established. By contrast, propagating the primary tumor cells in serum-containing medium as adherent populations resulted in a several thousand-fold reduction in their tumor-initiating cell fraction. Our findings suggest that experimental conditions, including the sensitivity of the transplantation assay, can dramatically affect estimates of tumor initiating cell frequency. Moreover, conditional on cell culture conditions, the tumor-initiating cell fraction of bulk mouse mammary tumor cell preparations can either be maintained at high or low frequency in vitro thus permitting comparative studies of tumorigenic and non-tumorigenic cancer cells.

Published
2013

29. Significance of a nitric oxide reserve and its utilisation in the human circulation

Author

Rogers, Stephen Colin

Subjects
612.015
Abstract

Historically nitric oxide (NO) was viewed as playing a purely paracrine role in the vasculature, acting within the vicinity of its release. Today an endocrine role of NO metabolites is widely accepted, although the species accounting for the vascular regulatory function still remains in contention. The original aim of this thesis was to analyse the two main NO metabolite hypotheses (i.e., SNO-Hb and nitrite hypotheses) to provide a more comprehensive understanding of their potential significance in the human circulation. Initially this involved developing methods capable of measuring baseline levels of NO metabolites in human blood. During this work a major confounding factor was identified influencing the measurement of NO attached to red blood cells/haemoglobin. A means was developed to overcome this via the modification an assay reagent, which was used along with several other methods to analyse NO metabolites in human blood. Ultimately however, levels of SNO-Hb at baseline were on the border of methodological sensitivity, although haemoglobin-bound NO was distinguishable. Consequently my work focused on the potential of nitrite versus haemoglobin-bound NO per se to act as endocrine NO metabolites in the human vasculature. Nitrite metabolism in human whole blood was analysed whilst the vasodilatory properties of nitrite were investigated in relation to the relaxation response observed from native red blood cells under hypoxic conditions. Finally for the first time ever NO metabolites were measured across the coronary and pulmonary vascular beds in the human circulation to address their potential to regulate vascular tone at baseline and under conditions of increased oxygen demand.

Published
2006

33. Defining modernism : the little magazine and the formulation and use of the term modernism in Anglo-American literary discourse, 1907-1983

Author

Rogers, Stephen Geoffrey

Abstract

This thesis is a survey of the construction of modernism. It traces the usage of the term from 1907 to 1983. The aim throughout has been to identify the evolving application of this word in order to account for its subsequent acceptance as the principal means of discussing the literary movement that appeared in the early part of the twentieth century. Particular attention has been given to the debates concerning 'modernity', 'the modern' and 'modernism', at the point that these key concepts were entering the intellectual and artistic arena. These debates have been primarily located in the little magazines of this period, with emphasis placed on the years 1914-1948. These publications were responsible for the establishment of many of the major literary figures of the twentieth century before their work was recognised by a wider audience and achieved pubic acclaim and academic endorsement. These magazines played a crucial role in the discussion of ideas necessary to the formation of the modern movement, and therefore provide a store of important exchanges in the creation of modernism. Many of the now familiar opinions regarding modernism were first formulated in this period of experimentation. This study explores these issues in relation to the wide range of social and intellectual factors that were part of the emergence of modern society in the early part of the twentieth century. There is focus on the relationship between the avant-garde and the com m unity at large, highlighting the particular problems encountered by the modern poet in establishing contact with a 'knowable' totality of experience shared with an audience, an audience becoming increasingly specialised and fragmented. The investigation concludes by giving emphasis to the way that the construction of modernism has been informed by the parallel debate in the Christian Church concerning the encroachm ent of modern scientific discoveries. The survey comes to the conclusion that 'm odernism ' represents a diverse, eosmopolitan and hybrid set of literary practices that record the fragmentation of the social environment whilst seeking a vision beyond the subjective.

Published
2004

35. Value added : from policy to classroom practice

Author

Rogers, Stephen G.

Subjects
373, Secondary schools
Abstract

Using a case-study methodology, this thesis enquires into the development of value-added from policy to classroom practice in a comprehensive school in the North of England. The study is unique in that it examines the work of teachers in relation to policy with a special focus on the extent to which value-added measures can be used to inform an understanding of what is going on at classroom level. It not only links quantitative and qualitative research paradigms, but does so at a level that has received relatively little attention and at a dramatic juncture in the history of teachers' professional lives. A literature survey shows that although originally conceived as a research tool, value-added was subsequently 'adopted' by secondary schools principally in response to government-imposed 'league tables'. A national value-added scheme has yet to be developed but, in a shift of policy, the government now promotes the use of value-added measures in the new Threshold Assessments of teachers. Value-added data for core subjects for seven years have been analysed at class level. Pupils in 'top' sets on average obtain positive residuals whilst in 'bottom' sets they are mostly negative. It is shown that this is partly a statistical artefact and therefore not a true reflection of teacher effectiveness. However, when teachers are interviewed they frequently reveal positive attitudes towards upper sets and the opposite with the lower ones. When value-added scores are considered alongside teacher interview data there are cases where residuals might be indicative of teacher performance but there are no universal patterns. Although there are some indications that pedagogical practice and teachers' backgrounds are linked with the performance of classes, it is concluded that the use of value-added data in the Threshold Assessment of teachers is flawed. Suggestions are made for further research including the use of value-added measures at classroom level.

Published
2002

38. Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end

Author

Slep, Kevin C, Rogers, Stephen L, Elliott, Sarah L, Ohkura, Hiroyuki, Kolodziej, Peter A, and Vale, Ronald D

Subjects
Biochemistry and Cell Biology, Biological Sciences, Aetiology, 2.1 Biological and endogenous factors, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Good Health and Well Being, Adenomatous Polyposis Coli Protein, Amino Acid Motifs, Amino Acid Sequence, Animals, Binding Sites, Cells, Cultured, Drosophila, Microfilament Proteins, Microtubule-Associated Proteins, Microtubules, Models, Molecular, Molecular Sequence Data, Mutagenesis, Protein Binding, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

EB1 is a member of a conserved protein family that localizes to growing microtubule plus ends. EB1 proteins also recruit cell polarity and signaling molecules to microtubule tips. However, the mechanism by which EB1 recognizes cargo is unknown. Here, we have defined a repeat sequence in adenomatous polyposis coli (APC) that binds to EB1's COOH-terminal domain and identified a similar sequence in members of the microtubule actin cross-linking factor (MACF) family of spectraplakins. We show that MACFs directly bind EB1 and exhibit EB1-dependent plus end tracking in vivo. To understand how EB1 recognizes APC and MACFs, we solved the crystal structure of the EB1 COOH-terminal domain. The structure reveals a novel homodimeric fold comprised of a coiled coil and four-helix bundle motif. Mutational analysis reveals that the cargo binding site for MACFs maps to a cluster of conserved residues at the junction between the coiled coil and four-helix bundle. These results provide a structural understanding of how EB1 binds two regulators of microtubule-based cell polarity.

Published
2005

39. Glycosylation of immunoglobulin G in cerebrospinal fluid and multiple sclerosis

Author

Rogers, Stephen

Subjects
572, MS, Isoelectric focusing, Oligoclonal
Abstract

The glycosylation features of CSF oligoclonal IgG, and possible changes in N-glycans of CSF IgG in multiple sclerosis (MS) were studied. After isoelectric focusing (IEF) of CSF, bands were detected using biotinylated lectins and avidin-horseradish peroxidase. Concanavalin A (Con A) binding showed that mannose exists throughout the pH range of oligoclonal IgG. Sambucus nigra antigen (SNA) bound acidic and neutral oligoclonal IgG only, suggesting that alkaline oligoclonal IgG is deficient in sialic acid. Deglycosylation of CSF IgG using peptide-N-glycosidase F suggested that the range of isoelectric points of oligoclonal IgG bands is not due to carbohydrate differences alone. Lectin immunoassays, whereby protein A purified IgG was captured by anti-IgG coated tubes and probed using a range of biotinylated lectins, were used to compare 13 CSF samples from MS patients with 14 control samples. With Con A binding, a significantly higher mean and larger variance was found for the MS group (t-test: P < 0.05). Con A binding correlated with CSF [IgG]/[total protein]% (r=0.390; P=0.0443). Using HPLC to separate oligosaccharides released from IgG by hydrazinolysis and labelled with 2-aminobenzamide, glycans were determined in 7 CSF samples with oligoclonal IgG, and 6 CSF samples without. The ratio of the peak for biantennary fucosylated agalactosyl glycans to total monogalactosylated glycan peaks was lower for the oligoclonal IgG samples (t-test: P=0.0141). The overall results suggested that glycosylation changes occur in CSF IgG in MS, and that oligoclonal IgG contains less sialic acid but more galactose than polyclonal IgG.

Published
2001

40. Urban wildflower meadow planting for biodiversity, climate and society: An evaluation at King's College, Cambridge

Author

Marshall, Cicely A. M., primary, Wilkinson, Matthew T., additional, Hadfield, Peter M., additional, Rogers, Stephen M., additional, Shanklin, Jonathan D., additional, Eversham, Brian C., additional, Healey, Roberta, additional, Kranse, Olaf P., additional, Preston, Chris D., additional, Coghill, Steven J., additional, McGonigle, Karris L., additional, Moggridge, Geoffrey D., additional, Pilbeam, Peter G., additional, Marza, Ana C., additional, Szigecsan, Darinka, additional, Mitchell, Jill, additional, Hicks, Marcus A., additional, Wallis, Sky M., additional, Xu, Zhifan, additional, Toccaceli, Francesca, additional, McLennan, Calum M., additional, and Eves‐van den Akker, Sebastian, additional

Published
2023
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42. Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

Author

Buglak, Danielle B, primary, Bougaran, Pauline, additional, Kulikauskas, Molly R, additional, Liu, Ziqing, additional, Monaghan-Benson, Elizabeth, additional, Gold, Ariel L, additional, Marvin, Allison P, additional, Burciu, Andrew, additional, Tanke, Natalie T, additional, Oatley, Morgan, additional, Ricketts, Shea N, additional, Kinghorn, Karina, additional, Johnson, Bryan N, additional, Shiau, Celia E, additional, Rogers, Stephen, additional, Guilluy, Christophe, additional, and Bautch, Victoria L, additional

Published
2023
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49. Hematologic Disorders

Author

Rogers, Stephen, Silva, Manuel, Doctor, Allan, Armstrong, Donald, Editor-in-chief, Tsukahara, Hirokazu, editor, and Kaneko, Kazunari, editor

Published
2014
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