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1. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort

Author

Aghemo, Alessio, Baiguera, Chiara, Battezzati, Pier Maria, Battistella, Sara, Bavetta, Maria Grazia, Bertoni, Costanza, Boni, Carolina, Brambilla, Paola, Bray, Antonella, Briano, Federica, Carmenini, Enrico, Castelli, Francesco, Cavalletto, Luisa, Cerini, Federica, Chidichimo, Luciana, Colella, Elisa, Cologni, Giuliana, Como, Silvia, Corsini, Romina, Costa, Chiara, Cotugno, Rosa, Cretella, Silvia, De Angelis, Fernando, De Leo, Pasqualina, Perri, Giovanni Di, Falbo, Elisabetta, Ferrigno, Luigina, Fornasiere, Ezio, Francisci, Daniela, Gatti, Pietro, Lampertico, Pietro, Lenci, Ilaria, Licata, Anna, Maida, Ivana, Marzano, Alfredo, Mastroianni, Antonio, Mazzaro, Cesare, Monti, Monica, Nardone, Gerardo, Nicolini, Laura Ambra, Passigato, Nicola, Pasticci, Maria Bruna, Pierotti, Piera, Pinchera, Biagio, Pollicino, Teresa, Porcu, Carmen, Quartini, Giulia, Rancatore, Gabriele, Romeo, Mario, Rumi, Maria Grazia, Saracino, Annalisa, Schioppa, Ornella, Serio, Ilaria, Soffredini, Roberta, Tata, Xhimi, Tizzani, Marco, Tonnini, Matteo, Torti, Carlo, Valenti, Daniela, Zaltron, Serena, Zoncada, Alessia, Kondili, Loreta A., Brancaccio, Giuseppina, Tosti, Maria Elena, Coco, Barbara, Quaranta, Maria Giovanna, Messina, Vincenzo, Ciancio, Alessia, Morisco, Filomena, Cossiga, Valentina, Claar, Ernesto, Rosato, Valerio, Ciarallo, Marianna, Cacciola, Irene, Ponziani, Francesca Romana, Cerrito, Lucia, Coppola, Roberta, Longobardi, Francesco, Biliotti, Elisa, Rianda, Alessia, Barbaro, Francesco, Coppola, Nicola, Stanzione, Maria, Barchiesi, Francesco, Fagiuoli, Stefano, Viganò, Mauro, Massari, Marco, Russo, Francesco Paolo, Ferrarese, Alberto, Laccabue, Diletta, Di Marco, Vito, Blanc, Pierluigi, Marrone, Aldo, Morsica, Giulia, Federico, Alessandro, Ieluzzi, Donatella, Rocco, Alba, Foschi, Francesco Giuseppe, Soria, Alessandro, Chessa, Luchino, Milella, Michele, Rosselli Del Turco, Elena, Madonia, Salvatore, Chemello, Liliana, Gentile, Ivan, Toniutto, Pierluigi, Bassetti, Matteo, Surace, Lorenzo, Baiocchi, Leonardo, Pellicelli, Adriano, De Santis, Adriano, Puoti, Massimo, Degasperi, Elisabetta, Niro, Grazia Anna, Zignego, Anna Linda, Craxi, Antonio, Raimondo, Giovanni, Santantonio, Teresa Antonia, Brunetto, Maurizia Rossana, and Gaeta, Giovanni Battista

Published
2024
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2. Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination

Author

Pasulo, Luisa, Coppola, Carmine, Pisano, Federica, Romano, Mariarosaria, Porcu, Carmen, Bottalico, Irene Francesca, Cossiga, Valentina, Tata, Xhimi, Sagnelli, Caterina, Pierotti, Piera, Degasperi, Elisabetta, Rosato, Valerio, Badia, Lorenzo, Ieluzzi, Dontella, Monti, Monica, Bavetta, Maria Grazia, Cavalletto, Luisa, Toniutto, Pierluigi, Fornasiere, Ezio, Colecchia, Antonio, Ferrarese, Alberto, Nardone, Gerardo, Rocco, Alba, Viganò, Mauro, Foschi, Francesco Giuseppe, Conti, Fabio, Morsica, Giulia, Salpietro, Stefania, Torti, Carlo, Costa, Chiara, Federico, Alessandro, Dallio, Marcello, Giorgini, Alessia, Anselmo, Marco, De Leo, Pasqualina, Zaltron, Serena, Cambianica, Anna, Piscaglia, Fabio, Serio, Ilaria, Schivazappa, Simona, Mastroianni, Antonio, Chidichimo, Luciana, Massari, Marco, Mazzaro, Cesare, Marrone, Aldo, D'Amore, Francesca Maria, D'Offizi, Gianpiero, Licata, Anna, Niro, Grazia Anna, Pollicino, Teresa, Aghemo, Alessio, Brancaccio, Giuseppina, Coco, Barbara, Nardi, Alessandra, Quaranta, Maria Giovanna, Tosti, Maria Elena, Ferrigno, Luigina, Cacciola, Irene, Messina, Vincenzo, Chessa, Luchino, Morisco, Filomena, Milella, Michele, Barbaro, Francesco, Ciancio, Alessia, Russo, Francesco Paolo, Coppola, Nicola, Blanc, Pierluigi, Claar, Ernesto, Verucchi, Gabriella, Puoti, Massimo, Zignego, Anna Linda, Chemello, Liliana, Madonia, Salvatore, Fagiuoli, Stefano, Marzano, Alfredo, Ferrari, Carlo, Lampertico, Pietro, Di Marco, Vito, Craxì, Antonio, Santantonio, Teresa Antonia, Raimondo, Giovanni, Brunetto, Maurizia R., Gaeta, Giovanni Battista, and Kondili, Loreta A.

Published
2023
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3. LBP-038 Expanding knowledge regarding real-world treatment of patients with primary biliary cholangitis with obeticholic acid from the Italian RECAPITULATE cohort

Author

Terracciani, Francesca, primary, De Vincentis, Antonio, additional, D'Amato, Daphne, additional, Scaravaglio, Miki, additional, Invernizzi, Pietro, additional, Vanni, Ester, additional, Campion, Daniela, additional, Floreani, Annarosa, additional, Cazzagon, Nora, additional, Alvaro, Domenico, additional, Venere, Rosanna, additional, Giannini, Edoardo, additional, Labanca, Sara, additional, Lleo, Ana, additional, Colapietro, Francesca, additional, Degasperi, Elisabetta, additional, Vigano, Mauro, additional, Pesatori, Eugenia Vittoria, additional, Fagiuoli, Stefano, additional, Marzioni, Marco, additional, Buzzanca, Valerio, additional, Vigano, Raffaella, additional, D'Amico, Federico, additional, Galli, Andrea, additional, Curto, Armando, additional, Marra, Fabio, additional, Begini, Paola, additional, Baiocchi, Leonardo, additional, Carni, Paola, additional, Muratori, Luigi, additional, Coco, Barbara, additional, Brunetto, Maurizia, additional, Pizzolante, Fabrizio, additional, De Matthaeis, Nicoletta, additional, Falbo, Elisabetta, additional, Surace, Lorenzo, additional, Mattalia, Alberto, additional, Ieluzzi, Donatella, additional, Salomone, Federico, additional, Monache, Guido Delle, additional, Tatonetti, Riccardo, additional, Cavalli, Ilaria, additional, Cossiga, Valentina, additional, Morisco, Filomena, additional, Valiani, Vincenzo, additional, Gatti, Pietro, additional, Boccaccio, Vincenzo, additional, Angrisani, Debora, additional, Vettori, Giovanni, additional, Cuffari, Biagio, additional, Moretti, Alessandra, additional, Nardone, Gerardo, additional, Rocco, Alba, additional, Scivetti, Paolo, additional, Costanzo, Martina, additional, Boano, Valentina, additional, Manfredi, Giulia Francesca, additional, Simone, Loredana, additional, Palitti, Valeria Pace, additional, Russello, Maurizio, additional, Cannavo, Maria Rita, additional, Frazzetto, Evelise, additional, Bertino, Gaetano, additional, Distefano, Marco, additional, Izzi, Antonio, additional, Cerini, Federica, additional, Chessa, Luchino, additional, Miglianti, Michela, additional, Feletti, Valentina, additional, Mussetto, Alessandro, additional, Cozzolongo, Raffaele, additional, Losito, Francesco, additional, Niro, Grazia Anna, additional, Cotugno, Rosa, additional, Sacco, Rodolfo, additional, Ricci, Chiara, additional, Poisa, Paolo, additional, Cadamuro, Luca, additional, Castellaneta, Antonino, additional, Squeo, Francesco, additional, Terreni, Natalia, additional, Bina, Niccolo, additional, Pozzoni, Pietro, additional, Casella, Silvia, additional, Zani, Francesca, additional, Morelli, Olivia, additional, Cuccorese, Giuseppe, additional, Saitta, Carlo, additional, Zolfino, Teresa, additional, Rigamonti, Cristina, additional, Calvaruso, Vincenza, additional, Carbone, Marco, additional, and Vespasiani-Gentilucci, Umberto, additional

Published
2024
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4. THU-093 Biochemical response and liver stiffness variation over time predict liver-related events in patients with primary biliary cholangitis treated with Obeticholic acid

Author

Vincentis, Antonio De, primary, Terracciani, Francesca, additional, D'Amato, Daphne, additional, Scaravaglio, Miki, additional, Invernizzi, Pietro, additional, Vanni, Ester, additional, Campion, Daniela, additional, Floreani, Annarosa, additional, Cazzagon, Nora, additional, Alvaro, Domenico, additional, Venere, Rosanna, additional, Giannini, Edoardo, additional, Labanca, Sara, additional, Lleo, Ana, additional, Colapietro, Francesca, additional, Degasperi, Elisabetta, additional, Viganò, Mauro, additional, Pesatori, Eugenia Vittoria, additional, Fagiuoli, Stefano, additional, Marzioni, Marco, additional, Buzzanca, Valerio, additional, Viganò, Raffaella, additional, D'Amico, Federico, additional, Galli, Andrea, additional, Curto, Armando, additional, Marra, Fabio, additional, Begini, Paola, additional, Baiocchi, Leonardo, additional, Carnì, Paola, additional, Muratori, Luigi, additional, Coco, Barbara, additional, Brunetto, Maurizia, additional, Pizzolante, Fabrizio, additional, Matthaeis, Nicoletta De, additional, Falbo, Elisabetta, additional, Surace, Lorenzo, additional, Mattalia, Alberto, additional, Ieluzzi, Donatella, additional, Salomone, Federico, additional, Monache, Guido Delle, additional, Tatonetti, Riccardo, additional, Cavalli, Ilaria, additional, Cossiga, Valentina, additional, Morisco, Filomena, additional, Valiani, Vincenzo, additional, Gatti, Pietro, additional, Boccaccio, Vincenzo, additional, Angrisani, Debora, additional, Vettori, Giovanni, additional, Cuffari, Biagio, additional, Moretti, Alessandra, additional, Rocco, Alba, additional, Nardone, Gerardo, additional, Scivetti, Paolo, additional, Costanzo, Martina, additional, Boano, Valentina, additional, Manfredi, Giulia Francesca, additional, Simone, Loredana, additional, Palitti, Valeria Pace, additional, Russello, Maurizio, additional, Cannavò, Maria Rita, additional, Frazzetto, Evelise, additional, Bertino, Gaetano, additional, Distefano, Marco, additional, Izzi, Antonio, additional, Cerini, Federica, additional, Chessa, Luchino, additional, Miglianti, Michela, additional, Feletti, Valentina, additional, Mussetto, Alessandro, additional, Cozzolongo, Raffaele, additional, Losito, Francesco, additional, Niro, Grazia Anna, additional, Cotugno, Rosa, additional, Sacco, Rodolfo, additional, Ricci, Chiara, additional, Poisa, Paolo, additional, Cadamuro, Luca, additional, Castellaneta, Antonino, additional, Squeo, Francesco, additional, Terreni, Natalia, additional, Bina, Niccolò, additional, Pozzoni, Pietro, additional, Casella, Silvia, additional, Zani, Francesca, additional, Morelli, Olivia, additional, Cuccorese, Giuseppe, additional, Saitta, Carlo, additional, Zolfino, Teresa, additional, Rigamonti, Cristina, additional, Calvaruso, Vincenza, additional, Carbone, Marco, additional, and Vespasiani-Gentilucci, Umberto, additional

Published
2024
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6. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and Delta cohort

Author

Kondili, Loreta A., primary, Brancaccio, Giuseppina, additional, Tosti, Maria Elena, additional, Coco, Barbara, additional, Quaranta, Maria Giovanna, additional, Messina, Vincenzo, additional, Ciancio, Alessia, additional, Morisco, Filomena, additional, Cossiga, Valentina, additional, Claar, Ernesto, additional, Rosato, Valerio, additional, Ciarallo, Marianna, additional, Cacciola, Irene, additional, Ponziani, Francesca Romana, additional, Cerrito, Lucia, additional, Coppola, Roberta, additional, Longobardi, Francesco, additional, Biliotti, Elisa, additional, Rianda, Alessia, additional, Barbaro, Francesco, additional, Coppola, Nicola, additional, Stanzione, Maria, additional, Barchiesi, Francesco, additional, Fagiuoli, Stefano, additional, Viganò, Mauro, additional, Massari, Marco, additional, Russo, Francesco Paolo, additional, Ferrarese, Alberto, additional, Laccabue, Diletta, additional, Marco, Vito Di, additional, Blanc, Pierluigi, additional, Marrone, Aldo, additional, Morsica, Giulia, additional, Federico, Alessandro, additional, Ieluzzi, Donatella, additional, Rocco, Alba, additional, Foschi, Francesco Giuseppe, additional, Soria, Alessandro, additional, Maida, Ivana, additional, Chessa, Luchino, additional, Milella, Michele, additional, Turco, Elena Rosselli del, additional, Madonia, Salvatore, additional, Chemello, Liliana, additional, Gentile, Ivan, additional, Toniutto, Pierluigi, additional, Bassetti, Matteo, additional, Surace, Lorenzo, additional, Baiocchi, Leonardo, additional, Pellicelli, Adriano, additional, De Santis, Adriano, additional, Puoti, Massimo, additional, Degasperi, Elisabetta, additional, Niro, Grazia Anna, additional, Zignego, Anna Linda, additional, Craxi, Antonio, additional, Raimondo, Giovanni, additional, Santantonio, Teresa Antonia, additional, Brunetto, Maurizia Rossana, additional, Gaeta, Giovanni Battista, additional, and Investigators, on behalf of PITER Collaborating, additional

Published
2024
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7. Effectiveness and predictors of response to somatostatin analogues in patients with gastrointestinal angiodysplasias: a systematic review and individual patient data meta-analysis

Author

Goltstein, Lia C M J, Grooteman, Karina V, Rocco, Alba, Holleran, Grainne, Frago, Santiago, Salgueiro, Paulo S, Aparicio, Thomas, Scaglione, Giuseppe, Chetcuti Zammit, Stefania, Prados-Manzano, Raul, Benamouzig, Robert, Nardone, Gerardo, McNamara, Deirdre, Benallaoua, Mourad, Michopoulos, Spyridon, Sidhu, Reena, Kievit, Wietske, Drenth, Joost P H, and van Geenen, Erwin J M

Published
2021
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13. Epidemiological and clinical profile of HDV infected people in care in Italy: interim analysis from the ongoing PITER cohort

Author

Kondili, Loreta, primary, Tosti, Maria Elena, additional, Quaranta, Maria Giovanna, additional, Ciancio, Alessia, additional, Messina, Vincenzo, additional, Brancaccio, Giuseppina, additional, Brunetto, Maurizia, additional, Capasso, Mario, additional, Rosato, Valerio, additional, Cacciola, Irene, additional, Pasulo, Luisa, additional, Santantonio, Teresa, additional, Coppola, Carmine, additional, Biliotti, Elisa, additional, Barbaro, Francesco, additional, Massari, Marco, additional, Coppola, Nicola, additional, Ferrarese, Alberto, additional, Russo, Francesco Paolo, additional, Di Marco, Vito, additional, Marrone, Aldo, additional, Schivazappa, Simona, additional, Federico, Alessandro, additional, Blanc, Pierluigi, additional, Rocco, Alba, additional, Morsica, Giulia, additional, Ieluzzi, Donatella, additional, Conti, Fabio, additional, De Siena, Martina, additional, Bavetta, Maria Grazia, additional, Milella, Michele, additional, Gentile, Ivan, additional, Porcu, Carmen, additional, Chemello, Liliana, additional, Maracci, Monia, additional, Zignego, Anna Linda, additional, Baiocchi, Leonardo, additional, Maida, Ivana Rita, additional, and Coco, Barbara, additional

Published
2023
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14. Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination

Author

Brancaccio, Giuseppina, primary, Coco, Barbara, additional, Nardi, Alessandra, additional, Quaranta, Maria Giovanna, additional, Tosti, Maria Elena, additional, Ferrigno, Luigina, additional, Cacciola, Irene, additional, Messina, Vincenzo, additional, Chessa, Luchino, additional, Morisco, Filomena, additional, Milella, Michele, additional, Barbaro, Francesco, additional, Ciancio, Alessia, additional, Russo, Francesco Paolo, additional, Coppola, Nicola, additional, Blanc, Pierluigi, additional, Claar, Ernesto, additional, Verucchi, Gabriella, additional, Puoti, Massimo, additional, Zignego, Anna Linda, additional, Chemello, Liliana, additional, Madonia, Salvatore, additional, Fagiuoli, Stefano, additional, Marzano, Alfredo, additional, Ferrari, Carlo, additional, Lampertico, Pietro, additional, Di Marco, Vito, additional, Craxì, Antonio, additional, Santantonio, Teresa Antonia, additional, Raimondo, Giovanni, additional, Brunetto, Maurizia R., additional, Gaeta, Giovanni Battista, additional, Kondili, Loreta A., additional, Pasulo, Luisa, additional, Coppola, Carmine, additional, Pisano, Federica, additional, Romano, Mariarosaria, additional, Porcu, Carmen, additional, Bottalico, Irene Francesca, additional, Cossiga, Valentina, additional, Tata, Xhimi, additional, Sagnelli, Caterina, additional, Pierotti, Piera, additional, Degasperi, Elisabetta, additional, Rosato, Valerio, additional, Badia, Lorenzo, additional, Ieluzzi, Dontella, additional, Monti, Monica, additional, Bavetta, Maria Grazia, additional, Cavalletto, Luisa, additional, Toniutto, Pierluigi, additional, Fornasiere, Ezio, additional, Colecchia, Antonio, additional, Ferrarese, Alberto, additional, Nardone, Gerardo, additional, Rocco, Alba, additional, Viganò, Mauro, additional, Foschi, Francesco Giuseppe, additional, Conti, Fabio, additional, Morsica, Giulia, additional, Salpietro, Stefania, additional, Torti, Carlo, additional, Costa, Chiara, additional, Federico, Alessandro, additional, Dallio, Marcello, additional, Giorgini, Alessia, additional, Anselmo, Marco, additional, De Leo, Pasqualina, additional, Zaltron, Serena, additional, Cambianica, Anna, additional, Piscaglia, Fabio, additional, Serio, Ilaria, additional, Schivazappa, Simona, additional, Mastroianni, Antonio, additional, Chidichimo, Luciana, additional, Massari, Marco, additional, Mazzaro, Cesare, additional, Marrone, Aldo, additional, D'Amore, Francesca Maria, additional, D'Offizi, Gianpiero, additional, Licata, Anna, additional, Niro, Grazia Anna, additional, Pollicino, Teresa, additional, and Aghemo, Alessio, additional

Published
2023
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15. Effectiveness of first and second-line empirical treatment in Italy: Results of the European registry on Helicobacter pylori management

Author

Gatta, Gian Luigi, Nyssen, Olga P, Fiorini, Giulia, Saracino, Ilaria Maria, Pavoni, Matteo, Romano, Marco, Gravina, Antonietta Gerarda, Granata, Lucia, Pellicano, Rinaldo, Gasbarrini, Antonio, Di Leo, Alfredo, Losurdo, Giuseppe, Franceschi, Francesco, Nardone, Gerardo, Rocco, Alba, Dore, Maria Pina, Farinati, Fabio, Ghisa, Matteo, Bellini, Massimo, Holton, John, Puig, Ignasi, Vaira, Dino, Borghi, Claudio, Mégraud, Franci, O'Morain, Colm, Gisbert, Javier P, Gatta, Luigi, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Gatta, Gian Luigi, Nyssen, Olga P, Fiorini, Giulia, Saracino, Ilaria Maria, Pavoni, Matteo, Romano, Marco, Gravina, Antonietta Gerarda, Granata, Lucia, Pellicano, Rinaldo, Gasbarrini, Antonio, Di Leo, Alfredo, Losurdo, Giuseppe, Franceschi, Francesco, Nardone, Gerardo, Rocco, Alba, Dore, Maria Pina, Farinati, Fabio, Ghisa, Matteo, Bellini, Massimo, Holton, John, Puig, Ignasi, Vaira, Dino, Borghi, Claudio, Mégraud, Franci, O'Morain, Colm, Gisbert, Javier P, Gatta, Luigi, Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Franceschi, Francesco (ORCID:0000-0001-6266-445X)

Abstract

Background and AimsThe optimal management of naive and not naive Helicobacter pylori patients remains unclear. Therefore, it is essential to evaluate whether the actual clinical practice mirrors the indications suggested by the guidelines. This study aimed to assess the effectiveness and the safety of the empirical first- and second-line treatments prescribed to patients enroled at Italian centres participating in the European Registry on H. pylori Management (Hp-EuReg). MethodsThe Hp-EuReg is an international multicentre prospective non-interventional registry starting in 2013 aiming to evaluate the management of H. pylori infection by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap. Variables assessed included demographics, previous eradication attempts, treatment regimen, effectiveness, and tolerance. ResultsOverall, 3723 patients from 2013 to February 2021 were included: 2996 and 727 received an empirical first- and second-line treatment, respectively. According to the modified ITT analysis, among the first-line regimens, only the bismuth quadruple therapy with three-in-one-single capsule (BQT-TSC), the concomitant, and the sequential treatment - all lasting 10 days - achieved an eradication rate >90%. Among the second-line regimens, only the 10-day BQT-TSC reported an effectiveness >90%. High-dose PPI twice daily also significantly increased the effectiveness of some therapies. The BQT-TSC was the regimen with the highest incidence of adverse events. ConclusionsOnly quadruple therapies lasting at least 10 days achieved over 90% eradication rates among the empirical first- and second-line regimens. It remains unclear whether high-dose PPI twice daily can improve the efficacy of quadruple treatment.

Published
2023

16. Autoimmune liver diseases and SARS-CoV-2

Author

Sgamato, Costantino, primary, Rocco, Alba, additional, Compare, Debora, additional, Minieri, Stefano, additional, Marchitto, Stefano Andrea, additional, Maurea, Simone, additional, and Nardone, Gerardo, additional

Published
2023
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18. Effectiveness of first and second‐line empirical treatment in Italy: Results of the European registry on Helicobacter pylori management

Author

Gatta, Luigi, primary, Nyssen, Olga P., additional, Fiorini, Giulia, additional, Saracino, Ilaria Maria, additional, Pavoni, Matteo, additional, Romano, Marco, additional, Gravina, Antonietta Gerarda, additional, Granata, Lucia, additional, Pellicano, Rinaldo, additional, Gasbarrini, Antonio, additional, Di Leo, Alfredo, additional, Losurdo, Giuseppe, additional, Franceschi, Francesco, additional, Nardone, Gerardo, additional, Rocco, Alba, additional, Dore, Maria Pina, additional, Farinati, Fabio, additional, Ghisa, Matteo, additional, Bellini, Massimo, additional, Holton, John, additional, Puig, Ignasi, additional, Vaira, Dino, additional, Borghi, Claudio, additional, Mégraud, Francis, additional, O'Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2022
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25. BAG3 protein delocalisation in prostate carcinoma

Author

Staibano, Stefania, Mascolo, Massimo, Di Benedetto, Maria, Vecchione, Maria Luisa, Ilardi, Gennaro, Di Lorenzo, Giuseppe, Autorino, Riccardo, Salerno, Vincenzo, Morena, Antonella, Rocco, Alba, Turco, Maria Caterina, and Morelli, Emilio

Published
2010
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26. Empirical levofloxacin-containing versus clarithromycin-containing sequential therapy for Helicobacter pylori eradication: a randomised trial

Author

Romano, Marco, Cuomo, Antonio, Gravina, Antonietta G., Miranda, Agnese, Iovene, Maria Rosaria, Tiso, Angelo, Sica, Mariano, Rocco, Alba, Salerno, Raffaele, Marmo, Riccardo, Federico, Alessandro, and Nardone, Gerardo

Subjects
Helicobacter pylori -- Drug therapy, Helicobacter pylori -- Patient outcomes, Levofloxacin -- Usage, Levofloxacin -- Comparative analysis, Levofloxacin -- Health aspects, Clarithromycin -- Usage, Clarithromycin -- Comparative analysis, Clarithromycin -- Health aspects, Drug therapy -- Usage, Drug therapy -- Comparative analysis, Drug therapy -- Patient outcomes, Health
Published
2010

27. Protective effects of Lactobacillus paracasei F19 in a rat model of oxidative and metabolic hepatic injury

Author

Nardone, Gerardo, Compare, Debora, Liguori, Eleonora, Di Mauro, Valentina, Rocco, Alba, Barone, Michele, Napoli, Anna, Lapi, Dominga, Iovene, Maria Rosaria, and Colantuoni, Antonio

Subjects
Lactobacillus -- Health aspects, Oxidative stress -- Physiological aspects, Oxidative stress -- Models, Liver diseases -- Physiological aspects, Liver diseases -- Models, Biological sciences
Abstract

The liver is susceptible to such oxidative and metabolic stresses as ischemia-reperfusion (I/R) and fatty acid accumulation. Probiotics are viable microorganisms that restore the gut microbiota and exert a beneficial effect on the liver by inhibiting bacterial enzymes, stimulating immunity, and protecting intestinal permeability. We evaluated Lactobacillus paracasei F19 (LP-F19), for its potential protective effect, in an experimental model of I/R (30 min ischemia and 60 min reperfusion) in rats fed a standard diet or a steatogen [methionine/choline-deficient (MCD)] diet. Both groups consisted of 7 sham-operated rats, 10 rats that underwent I/R, and 10 that underwent I/R plus 8 wk of probiotic dietary supplementation. In rats fed a standard diet, I/R induced a decrease in sinusoid perfusion (P < 0.001), severe liver inflammation, and necrosis besides an increase of tissue levels of malondialdehyde (P < 0.001), tumor necrosis factor-[alpha] (P < 0.001), interleukin (IL)-1[beta] (P < 0.001), and IL-6 (P < 0.001) and of serum levels of transaminase (P < 0.001) and lipopolysaccharides (P < 0.001) vs. sham-operated rats. I/R also induced a decrease in Bacterioides, Bifidobacterium, and Lactobacillus spps (P < 0.01, P < 0.001, and P < 0.001, respectively) and an increase in Enterococcus and Enterobacteriaceae (P < 0.01 and P < 0.001, respectively) on intestinal mucosa. The severity of liver and gut microbiota alterations induced by I/R was even greater in rats with liver inflammation and steatosis, i.e., MCD-fed animals. LP-F19 supplementation significantly reduced the harmful effects of I/R on the liver and on gut microbiota in both groups of rats, although the effect was slightly less in MCD-fed animals. In conclusion, LP-FI9 supplementation, by restoring gut microbiota, attenuated I/R-related liver injury, particularly in the absence of steatosis. ischemia-reperfusion; Lactobacillus paracasei F19; nonalcoholic fatty liver disease; probiotics doi: 10.1152/ajpgi.00188.2010.

Published
2010

28. Effectiveness of first and second‐line empirical treatment in Italy: Results of the European registry on Helicobacter pylorimanagement

Author

Gatta, Luigi, Nyssen, Olga P., Fiorini, Giulia, Saracino, Ilaria Maria, Pavoni, Matteo, Romano, Marco, Gravina, Antonietta Gerarda, Granata, Lucia, Pellicano, Rinaldo, Gasbarrini, Antonio, Di Leo, Alfredo, Losurdo, Giuseppe, Franceschi, Francesco, Nardone, Gerardo, Rocco, Alba, Dore, Maria Pina, Farinati, Fabio, Ghisa, Matteo, Bellini, Massimo, Holton, John, Puig, Ignasi, Vaira, Dino, Borghi, Claudio, Mégraud, Francis, O'Morain, Colm, and Gisbert, Javier P.

Abstract

The optimal management of naïve and not naïve Helicobacter pyloripatients remains unclear. Therefore, it is essential to evaluate whether the actual clinical practice mirrors the indications suggested by the guidelines. This study aimed to assess the effectiveness and the safety of the empirical first‐ and second‐line treatments prescribed to patients enroled at Italian centres participating in the European Registry on H. pyloriManagement (Hp‐EuReg). The Hp‐EuReg is an international multicentre prospective non‐interventional registry starting in 2013 aiming to evaluate the management of H. pyloriinfection by European gastroenterologists. Patients were registered in an e‐CRF by AEG‐REDCap. Variables assessed included demographics, previous eradication attempts, treatment regimen, effectiveness, and tolerance. Overall, 3723 patients from 2013 to February 2021 were included: 2996 and 727 received an empirical first‐ and second‐line treatment, respectively. According to the modified ITT analysis, among the first‐line regimens, only the bismuth quadruple therapy with three‐in‐one‐single capsule (BQT‐TSC), the concomitant, and the sequential treatment ‐ all lasting 10 days ‐ achieved an eradication rate >90%. Among the second‐line regimens, only the 10‐day BQT‐TSC reported an effectiveness >90%. High‐dose PPI twice daily also significantly increased the effectiveness of some therapies. The BQT‐TSC was the regimen with the highest incidence of adverse events. Only quadruple therapies lasting at least 10 days achieved over 90% eradication rates among the empirical first‐ and second‐line regimens. It remains unclear whether high‐dose PPI twice daily can improve the efficacy of quadruple treatment.

Published
2023
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30. Sa109 SOMATOSTATIN ANALOGS LEAD TO AN 82% REDUCTION IN RED BLOOD CELL TRANSFUSIONS IN PATIENTS WITH GASTROINTESTINAL BLEEDING DUE TO ANGIODYSPLASIAS: AN INDIVIDUAL PATIENT DATA META-ANALYSIS.

Author

Goltstein, Lia, primary, Grooteman, Karina V., additional, Rocco, Alba, additional, Holleran, Grainne, additional, Frago, Santiago, additional, Salgueiro, Paulo, additional, Aparicio, Thomas, additional, Scaglione, Giuseppe, additional, Zammit, Stefania Chetcuti, additional, Manzano, Raúl, additional, Benamouzig, Robert, additional, Mcnamara, Deirdre, additional, Benallaoua, Mourad, additional, Michopoulos, Spyridon, additional, Sidhu, Reena, additional, Kievit, Wietske, additional, Drenth, Joost, additional, and Van Geenen, Erwin-Jan M., additional

Published
2021
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31. Lactose Intolerance Assessed by Analysis of Genetic Polymorphism, Breath Test and Symptoms in Patients with Inflammatory Bowel Disease

Author

Nardone, Olga Maria, primary, Manfellotto, Francesco, additional, D’Onofrio, Caterina, additional, Rocco, Alba, additional, Annona, Giovanni, additional, Sasso, Francesca, additional, De Luca, Pasquale, additional, Imperatore, Nicola, additional, Testa, Anna, additional, de Sire, Roberto, additional, Biffali, Elio, additional, and Castiglione, Fabiana, additional

Published
2021
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35. WED-146 - Epidemiological and clinical profile of HDV infected people in care in Italy: interim analysis from the ongoing PITER cohort

Author

Kondili, Loreta, Tosti, Maria Elena, Quaranta, Maria Giovanna, Ciancio, Alessia, Messina, Vincenzo, Brancaccio, Giuseppina, Brunetto, Maurizia, Capasso, Mario, Rosato, Valerio, Cacciola, Irene, Pasulo, Luisa, Santantonio, Teresa, Coppola, Carmine, Biliotti, Elisa, Barbaro, Francesco, Massari, Marco, Coppola, Nicola, Ferrarese, Alberto, Russo, Francesco Paolo, Di Marco, Vito, Marrone, Aldo, Schivazappa, Simona, Federico, Alessandro, Blanc, Pierluigi, Rocco, Alba, Morsica, Giulia, Ieluzzi, Donatella, Conti, Fabio, De Siena, Martina, Bavetta, Maria Grazia, Milella, Michele, Gentile, Ivan, Porcu, Carmen, Chemello, Liliana, Maracci, Monia, Zignego, Anna Linda, Baiocchi, Leonardo, Maida, Ivana Rita, and Coco, Barbara

Published
2023
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43. Probiotics in Gastrointestinal Diseases: All that Glitters Is Not Gold.

Author

Compare, Debora, Sgamato, Costantino, Nardone, Olga Maria, Rocco, Alba, Coccoli, Pietro, Laurenza, Carmen, and Nardone, Gerardo

Subjects
GASTROINTESTINAL diseases, INFLAMMATORY bowel diseases, PROBIOTICS, GUT microbiome, IRRITABLE colon, INTESTINAL diseases, HELICOBACTER pylori infections
Abstract

Background: Multiple lines of evidence now support the notion that gut microbiota can contribute to digestive and extra-digestive diseases. The emergence of these observations enabled to postulate a bacteria-centric paradigm to rethink the treatment of many diseases. The goal of therapy should not be to eradicate the flora but to modify it in a way that leads to symptomatic improvement; thus, the interest in the use of probiotics to modulate microbiota composition has increased worldwide in both community and healthcare settings. Summary: The results of published studies are conflicting for most probiotic strains and formulations, and clinicians and consumers need a better understanding of probiotic risks and benefits. Currently, clear guidelines on when to use probiotics and the most effective probiotic for different gastrointestinal conditions are still lacking. Here, we reviewed the studies on the use of probiotics in some diseases of relevant interest to gastroenterologists, such as Helicobacter pylori infection, irritable bowel syndrome, and inflammatory bowel disease. Key Message: Although the evidence is relevant and promising for probiotics in general, and for specific strains and combinations of strains, it is not yet sufficient to draw unequivocal conclusions and clear recommendations. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Impact of proton pump inhibitors on cytochrome P450 activity assessed by 13C‐aminopyrine breath test in patients with cirrhosis.

Author

Rocco, Alba, Compare, Debora, Sgamato, Costantino, Coccoli, Pietro, Chiodini, Paolo, and Nardone, Gerardo

Subjects
*OMEPRAZOLE, *PROTON pump inhibitors, *CYTOCHROME P-450, *BREATH tests, *CIRRHOSIS of the liver, *CYTOCHROME c
Abstract

Summary: Background: Chronic use of proton pump inhibitors (PPIs) in patients with impaired liver function may worsen cytochrome P450 (CYP450) activity, predisposing them to clinically relevant drug–drug interactions. The 13C‐aminopyrine breath test (13C‐ABT) is a non‐invasive tool to study CYP450‐dependent liver function. Aims: To assess 13C‐ABT modifications with different PPIs in patients with cirrhosis Methods: Sixty consecutive patients with HCV‐related cirrhosis and indication to start PPI therapy were randomised to receive omeprazole 20 mg/day, esomeprazole 20 mg/day, lansoprazole 15 mg/day, pantoprazole 40 mg/day or rabeprazole 20 mg/day. 13C‐ABT was performed at baseline and on the 15th day of PPI therapy. Results: At baseline, mean values of max 13C% dose/h and 13C% cum dose at 120 minutes did not differ significantly among groups. On the 15th day of therapy, max 13C% dose/h and 13C% cum dose at 120 minutes did not significantly differ with respect to baseline for pantoprazole (P = 0.184 and P = 0.309, respectively) or rabeprazole (P = 0.536 and P = 0.286, respectively), but were significantly decreased on omeprazole (P = 0.013 and P = 0.015, respectively), esomeprazole (P = 0.009 and P = 0.001, respectively), and lansoprazole (P = 0.033 and P = 0.035, respectively). Conclusions: In patients with cirrhosis, omeprazole, esomeprazole and lansoprazole inhibit microsomal activity while pantoprazole and rabeprazole do not have a significant impact. Should our data be confirmed in larger cohort studies, pantoprazole and rabeprazole could be safely recommended for patients with cirrhosis. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Diverticular disease in elderly

Author

NARDONE, GERARDO ANTONIO PIO, COMPARE, DEBORA, ROCCO, ALBA, Guarracino M, Nardone OM, Sanduzzi Zamparelli M., Nardone, GERARDO ANTONIO PIO, Compare, Debora, Rocco, Alba, Guarracino, M, Nardone, Om, and Sanduzzi Zamparelli, M.

Abstract

The prevalence of diverticular disease (DD) increases with age, being reported in less than 5% of patients younger than 40 years and in 65-70% of patients older than 80 years. Diverticula represents the most frequent finding at colonoscopy. The pathogenesis of divericula is multifactorial, depending on diet and structural alterations of the colonic wall. Up to 75% of patients remain completely asymptomatic throughout their life while the remaining 25% of patients develops diverticular disease (DD) which includes symptomatic uncomplicated DD (20%) and diverticulitis (5%). The latter may be further complicated by perforation and bleeding (1-2% of the cases). In spite of the large amount of literature data, many unmet needs regarding risk factors, comorbidities, timing of surgery, neoplastic risk, and quality of life, still affect the management of patients with DD.

Published
2014

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