1. Structure, recognition and adaptive binding in RNA aptamer complexes
- Author
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Licong Jiang, Asif K Suri, Sylvie Nonin, Dinshaw J. Patel, Feng Jiang, R. Ajay Kumar, Pei Fan, Cibles Thérapeutiques et conception de médicaments (CiTCoM - UMR 8038), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Memorial Sloan Kettering Cancer Center (MSKCC), and Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)
- Subjects
Riboswitch ,Models, Molecular ,Magnetic Resonance Spectroscopy ,Stereochemistry ,Flavin Mononucleotide ,Aptamer ,Oligonucleotides ,Flavin mononucleotide ,010402 general chemistry ,Arginine ,01 natural sciences ,Cofactor ,03 medical and health sciences ,chemistry.chemical_compound ,Molecular recognition ,Structural Biology ,Nucleic acid structure ,amino acid and aminoglycoside antibiotic ligands ,Molecular Biology ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,biology ,sequence speci®c recognition and discrimination ,[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM] ,RNA aptamer complexes ,RNA ,Proteins ,cofactor ,Adenosine Monophosphate ,0104 chemical sciences ,Amino acid ,[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM] ,Biochemistry ,chemistry ,biology.protein ,Tobramycin ,Citrulline ,Nucleic Acid Conformation ,NMR based solution structures - Abstract
International audience; Novel features of RNA structure, recognition and discrimination have been recently elucidated through the solution structural characterizion of RNA aptamers that bind cofactors, aminoglycoside antibiotics, amino acids and peptides with high af®nity and speci®city. This review presents the solution structures of RNA aptamer complexes with adenosine monophosphate,¯avin mononucleotide, arginine/citrulline and tobramycin together with an example of hydrogen exchange measurements of the base-pair kinetics for the AMP-RNA aptamer complex. A comparative analysis of the structures of these RNA aptamer complexes yields the principles, patterns and diversity associated with RNA architecture, molecular recognition and adaptive binding associated with complex formation.
- Published
- 1997
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