55 results on '"RK Solanki"'
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2. The Impact of Cannabis Abuse on Psychotic Symptoms and Their Severity among Cannabis Associated Psychosis Subjects: An Indian Experience
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RK Solanki, Ramchandra Lamba, Ashok Kumar, Sona Budaniya, and Rajendera Kumar Acharya
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medicine.medical_specialty ,Psychosis ,Illicit Substance ,biology ,Grandiosity ,business.industry ,Cross-sectional study ,hostility ,lcsh:BF1-990 ,Hostility ,medicine.disease ,biology.organism_classification ,cannabis, psychosis ,excitement ,lcsh:Psychology ,Mood disorders ,medicine ,bprs ,General Earth and Planetary Sciences ,Cannabis ,medicine.symptom ,Family history ,business ,Psychiatry ,General Environmental Science - Abstract
Use of cannabis for recreational, religious and cultures has been prevalent since ancient times. It is one of the commonest used illicit substance. While not all cannabis users develop psychiatric problems, heavy cannabis use may increase the risk of cognitive abnormalities, psychotic illness and mood disorders. This research aimed to evaluate severity of various psychotic symptoms in relation to variables of cannabis abuse. A cross sectional study of 30 male patients admitted at tertiary care psychiatric center with diagnosis of cannabis-associated psychosis was carried out. Cannabis abuse variables along with psychotic symptoms severity on BPRS scale were obtained. Correlation between variables of cannabis abuse and psychotic symptoms and total BPRS score were derived using Pearson correlation 2- tailed test. Hostility (83%) and excitement (77%) were most prevalent symptoms with increased severity followed by elevated mood, grandiosity, suspiciousness and motor hyperactivity. Patients with long duration and early onset of cannabis abuse presented with more severe form of psychosis. Frequency of cannabis use was not significantly correlated with total BPRS score, although amount spent over cannabis was significantly associated with total BPRS score. Family history of cannabis abuse predicted early onset of cannabis abuse.
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- 2021
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3. Psychiatric morbidity and substance use in migrant workers: A population based study
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RK Solanki, Priti Arun, Sanjay Bahri, B S Chavan, Ravi Rohilla, Himanshu Sharrma, Raviprakash Sharma, Saikat Chakraborty, Gurvinder Pal Singh, Mankirat Kaur Murara, Chitra Singh, Ajeet Sidana, Madhur Verma, Dushant, and Jitender Aneja
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Transients and Migrants ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Substance-Related Disorders ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Migrant workers ,India ,medicine.disease ,Mental health ,030227 psychiatry ,Population based study ,Substance abuse ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Prevalence ,medicine ,Humans ,030212 general & internal medicine ,Substance use ,Migrant population ,Psychiatry ,business - Abstract
Background: The prevalence of mental health problems and substance abuse in the migrant population is higher than the general population. Aims and Objectives: To assess the prevalence and pattern of mental health issues and substance use in the migrant population and highlight the association with the reverse migration of migrant workers. Methodology: The field staff visited the shelter homes for migrant population in four cities of Northern India (Chandigarh (UT), Bhatinda (Punjab), Panchkula (Haryana) and Jaipur (Rajasthan). After maintaining the social distance and wearing masks by the staff and migrants, written informed consent was taken for participation in the study. The socio-demographic details of reverse migrants were noted down and Hindi version of Patient Health Questionnaire (PHQ-9) for mental health problems and screening tool for pattern of substance abuse was administered. Geographically matched undisplaced were also administered these tools. Results: A total of 275 reverse migrants and 276 undisplaced were included in the study. The prevalence of ever use for all the substances among reverse migrants was 44.4% (122/275) and among undisplaced, it was 45.3%. The prevalence of alcohol, tobacco and cannabis was higher than the general population. The prevalence of at least one diagnosis on PHQ-9 is 13.45% (reverse migrants 19.3% and undisplaced 7.6) and the prevalence of other depressive disorder is significantly higher in reverse migrants (17.1%) than undisplaced (4.0%). Conclusion: The study concludes that prevalence of mental health issues and substance abuse in migrant population is significantly higher than the general population and the prevalence of at least one diagnosis and other depressive disorder is significantly higher in reverse migrants than undisplaced.
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- 2021
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4. A COMPARATIVE STUDY OF CAREGIVER BURDEN AND ADHERENCE TO TREATMENT IN PATIENTS OF VERY LATE ONSET SCHIZOPHRENIA LIKE PSYCHOSIS (VLOSLP) AND DEMENTIA
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RK Solanki, Chitra Singh, and Himanshu Sharma
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Late onset schizophrenia ,medicine.medical_specialty ,Psychosis ,business.industry ,medicine ,Dementia ,In patient ,Caregiver burden ,Psychiatry ,business ,medicine.disease - Abstract
BACKGROUND: VLOSLPand dementia caused more lost quality of life, lost productivity and chronic and debilitating course of both disorders make it difcult for the family members and care givers to continue care and treatment. METHODOLOGY: Thirty-three patients of VLOSLP and dementia and their caregiver were selected after taking informed consent and screened with the entire inclusion and exclusion criteria. Socio-demographic prole of all patients and caregiver were recorded and Zarit Caregiver Burden Interview (ZBI) questionnaire and Drug Adherence inventory (DAI) applied to both groups. RESULTS AND CONCLUSION: Mean ZBI of VLOSLP was 41.85 ±13.28 and DAI was .94 ±3.784 (P. coeff. = -.682, p= .0001). Mean ZBI of dementia was 49.45 ±15.51 and DAI was -1.85 ±3.78 (P coeff. = -.935, p= .0001) indicated that the caregiver burden was more in patients of dementia and drug adherence was less then VLOSLP. There is a strong negative association between caregiver burden and compliance to the treatment.
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- 2020
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5. A study of cardiovascular risk among depressed obese patients
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Chitra Singh, RK Solanki, and Mohd Wasim
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cardiovascular risk ,medicine.medical_specialty ,obesity ,Supine position ,Framingham Risk Score ,business.industry ,lcsh:RC435-571 ,Disease ,medicine.disease ,Obesity ,High cholesterol ,Blood pressure ,Internal medicine ,lcsh:Psychiatry ,depression ,medicine ,business ,Body mass index ,Depression (differential diagnoses) - Abstract
Background: Both depression and obesity are widespread problems with major public health implications. Depression and obesity are both associated with an increased risk of cardiovascular disease (CVD) and with marked impairments in the quality of life. Aim and Objective: The aim of the study is to assess the CVD risk and cardiovascular risk factors among depressed obese individuals. Materials and Methods: Fifty patients of depression whose body mass index (BMI) >30 kg/m2 and diagnosed with ICD-10 criteria of depression were selected as study group and 30 healthy obese of BMI >30 kg/m2 without depression were selected as the control group for the study. The participants were divided into two groups: obese patients with depression and healthy obese individuals without depression. Fasting venous blood sample was collected under aseptic condition to estimate fasting blood sugar, total cholesterol, and high - density lipoprotein cholesterol. Using standard mercury manometer at least two readings at 5 - min intervals, were taken to measure the blood pressure (BP) in the supine position. Both the groups were subjected to specially designed pro forma which included personal and sociodemographic details and Framingham risk assessment tool for assessing cardiovascular risk. The cardiovascular risk was assessed and compared using Framingham risk score assessment tool. Results and Conclusion: Mean age of depressed obese was 46.44 ± 10.44 years and healthy obese had 47.33 ± 10.53. Mean BMI of study group was 32.82 ± 2.53 and healthy obese had 31.76 ± 1.66. BMI was significantly associated with depression. Presence of depression in obese patients increases the chances of CVD risk. Presence of smoking, hypertension, and high cholesterol in patients with depression, increase the risk of CVD, which can be modified by healthy diet, regular exercise, and BP management with periodic blood investigation and regular medication.
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- 2020
6. Factors Leading to Reverse Migration Among Migrant Workers During the COVID-19 Pandemic
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Raviprakash Sharma, Madhur Verma, Bir Singh Chavan, Jitender Aneja, RK Solanki, Ravi Rohilla, Mankirat Kaur Murara, Gurvinder Pal Singh, Sanjay Bahri, Ajeet Sidana, Priti Arun, Dushant Bhanwra, Chitra Singh, Saikat Chakraborty, and Himanshu Sharma
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Adult ,Employment ,Male ,Health Knowledge, Attitudes, Practice ,Adolescent ,Coronavirus disease 2019 (COVID-19) ,Cross-sectional study ,media_common.quotation_subject ,India ,Young Adult ,Pandemic ,Humans ,Medicine ,Family ,Socioeconomics ,Aged ,media_common ,Transients and Migrants ,business.industry ,Dry cough ,Migrant workers ,COVID-19 ,social sciences ,General Medicine ,Middle Aged ,Cross-Sectional Studies ,Feeling ,Multicenter study ,Communicable Disease Control ,behavior and behavior mechanisms ,population characteristics ,Female ,business ,Psychosocial ,geographic locations - Abstract
OBJECTIVE: To examine the various psychosocial factors associated with reverse migration among migrant workers during the coronavirus disease 2019 (COVID-19) lockdown in India. METHODS: A cross-sectional multicenter study was conducted at 4 sites in Northwest India. The migrant workers were recruited from various shelter homes, and information was gathered from reverse migrant workers and controls using various tools including a sociodemographic profile; knowledge, attitudes, and practices questionnaire; and reasons for migration and reverse migration questionnaires. A total of 275 reverse migrant workers and 276 controls participated in the study. RESULTS: There was a considerable difference between reverse migrant workers and controls regarding the question of whether it was safe to travel during lockdown (76.0% vs 26.4%, respectively). The most common route of spread of COVID-19 infection was through touching and sneezing, and symptoms were fever, dry cough, and sore throat in both groups. Reverse migrant workers had low self-esteem and were reluctant to participate in customs of their migration city. A large number of reverse migrant workers reported that they had no money to survive, worried about family back home at their village, felt pressured by family members to come back to the village, and had been terminated from their job. CONCLUSIONS: Reverse migrant workers had the attitude that it was safe to travel during the lockdown. About one-fifth of the reverse migrant workers reported no place to live and fear of getting an infection. The reverse migrant workers also reported feeling low and gloomy, restless, and uncertain about the future and fear of death. Lack of jobs was a major factor driving migrant workers from their native homes.
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- 2021
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7. Development of psychiatry curriculum as a major subject during MBBS in India
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Sai Krishna Tikka, RK Solanki, Anindya Das, Ravi Gupta, Jitendra Rohilla, Shobit Garg, Priyaranjan Avinash, Malay Dave, Vishal Dhiman, Aniruddha Basu, Ravi Kant, Vijay Krishnan, Manoj Kumar Gupta, Mohan Dhyani, Anil Nishchal, Vikram Singh Rawat, Sreeja Sahadevan, and Arghya Pal
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Psychiatry and Mental health ,Medical education ,Viewpoint ,Subject (documents) ,Psychology ,Curriculum - Published
- 2020
8. An adolescent with anorexia nervosa presenting with catatonia
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Shashi Kant Khanna, Gunjan Solanki, RK Solanki, Kuldeep Singh Yadav, Manish Kumar Goyal, and Rishika Agarwal
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Psychiatry and Mental health ,medicine.medical_specialty ,Anorexia nervosa (differential diagnoses) ,Catatonia ,business.industry ,medicine ,medicine.disease ,Psychiatry ,business ,Letters to Editor - Published
- 2021
9. PATTERN OF SUBSTANCE USE AMONG MEDICAL INTERNS IN TERTIARY HEALTH CARE CENTRE OF NORTH INDIA: A CROSSECTIONAL STUDY
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RK Solanki and Pragati Bhatnagar
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medicine.medical_specialty ,Geography ,Health care centre ,Family medicine ,education ,medicine ,Substance use ,North india - Abstract
A cross sectional study was conducted on 236 internship students in Department of Psychiatry, SMS Medical College. The study was intended to determine the prevalence, type and the pattern of substance use in medical interns. A self-designed semistructred questionnaire was used for the detailed interview after taking written informed consent from the students. Identity of the students were concealed. Data analysis was done using proportion and chi square test as statistical test. The lifetime prevalence of substance use was 74 % in our study. Males had signicantly higher lifetime and past month prevalence of substance use than females. Alcohol was the most commonly used substance followed by smoking. High prevalence of substance use in medical students emerge out a crucial problem in medical students which require an exigent need for change in interns by experienced professionals.
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- 2020
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10. Competency-based medical curriculum: Psychiatry, training of faculty, and Indian Psychiatric Society
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Mukesh Kumar Swami, Mohan Isaac, RK Solanki, Aniruddha Basu, Vishal Dhiman, Priyaranjan Avinash, Jitendra Rohilla, Vijay Krishnan, Vikram Singh Rawat, Rakesh K Chaddha, Malay Dave, Sreeja Sahadevan, Mohan Dyanin, Naresh Nebhinani, HR Vinay Kumar, Ravi Gupta, Henal Shah, Pankaj Kumar, MV Ashok, Sai Krishna Tikka, Rajat Ray, Anil Nishchal, Om Prakash Singh, Vikas Menon, Aragya Pal, Shobit Garg, Suhas Chandran, Anindya Das, Parmveer Singh, and M Kishor
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Psychiatry and Mental health ,Medical education ,Medical curriculum ,Psychology ,Training (civil) ,Ug Education - Published
- 2020
11. A study of thyroid profile in patients suffering from the first episode of mania: A cross-sectional study
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Kuldeep Singh Yadav, Manish Kumar Goyal, and RK Solanki
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First episode ,medicine.medical_specialty ,endocrine system ,endocrine system diseases ,Cross-sectional study ,business.industry ,Brief Research Communication ,thyroid profile ,Thyroid ,first-episode mania ,medicine.disease ,behavioral disciplines and activities ,Drug naïve ,Psychiatry and Mental health ,medicine.anatomical_structure ,Mood disorders ,Internal medicine ,Severity of illness ,mental disorders ,medicine ,medicine.symptom ,Thyroid function ,business ,Mania ,Subclinical infection - Abstract
Background: Thyroid function is commonly considered in the assessment of mood disorders. Reports of thyroid dysregulation in patients with mania are associated with several confounding factors. To eliminate confounding factors, studies of first-episode mania are desirable. This study tried to find out any relationship between thyroid disorders and mania. Aim: The aim of this study is to assess and compare the thyroid profile between first-episode mania and healthy controls and to ascertain the correlation between severity and duration of the manic episode with FT3, FT4, and thyroid-stimulating hormone (TSH) levels. Materials and Methods: This was a cross-sectional study conducted in the psychiatry department of a tertiary care hospital. Forty consecutive drug-naïve patients with first-episode mania, diagnosed according to the International Classification of Disease-10 (study group), were matched with 40 healthy controls (control group). Both the groups were compared on the basis of thyroid profile and thyroid levels were correlated with duration and severity of illness in the study group. Results: Nearly 7.5% of cases in the study group had hyperthyroidism, whereas 5% had subclinical hyperthyroidism. In contrast, normal controls showed 5% and 10% prevalence of hypothyroidism and subclinical hypothyroidism, respectively. A statistically significant lower level of TSH was observed in the study group (P < 0.001), whereas the mean serum levels of FT3 and FT4 were higher in the study group, but the difference was statistically nonsignificant. No significant correlation of thyroid hormones level with duration and severity of illness was noted. Conclusion: Our findings highlight a higher prevalence of hyperthyroidism in patients with mania and suggest the role of thyroid hormones in mania.
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- 2020
12. Why Psychosexual Disorders Equally Important in India
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RK Solanki and Rishika Agarwal
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Homicide ,Psychosexual development ,Prevalence ,Psychology ,Human sexuality ,RZ400-408 ,Mental healing ,Clinical psychology ,BF1-990 - Abstract
Human sexuality is a complex with multidimensional aspects such as biological, psychological, social, and cultural. Cultural factors influence their development as prevalence rates of these disorders vary in different communities. The nature of problems and their psychological consequences make it difficult to assess the exact prevalence of these dysfunctions, even more difficult in developing countries like India. In India, care for people is not proper as large number of patients suffering from psychosexual problems visit unauthorized “sex clinics” rather than an authorized hospital setting. Specialists like dermatologists are often consulted for these problems in their routine practice as common belief shared by them is that these problems are caused by dysfunctions in their sex organs. So they are hesitant to go to sexual clinics and psychiatrists for the same in the first place. The question that arises is where does sexual medicine stand, as asked by many in the past too but remains unanswered in terms of general medicine and psychiatry. Thus, the need of the hour is to identify these cases in early stages, which can prevent a lot of other disorders occurring due to them such as homicide, suicide, domestic violence, battered wife syndrome, etc. in society. The advance in psychosexual medicine is much needed. Despite the importance of these disorders and sensitivity, in India, there is scarcity of data about the burden of sexual health disorders from community-based studies, unlike Western countries.
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- 2020
13. Sleep Disorders
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RK Solanki and Nikhil Jain
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- 2018
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14. Mood Disorders
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BK Singh, SK Pandey, Ajit Avasthi, RK Solanki, Ashok Singhal, JN Vyas, Dinesh Tyagi, Neena Bohra, NK Bohra, Sandeep Grover, Alkananda Dutt, Baljit Saluja, and Manoj Dhungana
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- 2018
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15. An Indian experience of neurocognitive endophenotypic markers in unaffected first-degree relatives of schizophrenia patients
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Ashok Kumar, RK Solanki, Suresh Gupta, Paramjeet Singh, and Yogesh Satija
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medicine.medical_specialty ,Population ,neurocognition ,Context (language use) ,behavioral disciplines and activities ,03 medical and health sciences ,0302 clinical medicine ,medicine ,education ,Psychiatry ,education.field_of_study ,Working memory ,medicine.disease ,Executive functions ,030227 psychiatry ,schizophrenia ,Psychiatry and Mental health ,Endophenotype ,Schizophrenia ,Marfatia Award Paper, 2015 ,Verbal memory ,first degree relatives ,Psychology ,Neurocognitive ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Context: Multiple vulnerability genes interact with environmental factors to develop a range of phenotypes in the schizophrenia spectrum. Endophenotypes can help characterize the impact of risk genes by providing genetically relevant traits that are more complaisant than the behavioral symptoms that classify mental illness. Aims: We aimed to investigate the neurocognitive endophenotypic markers for schizophrenia in Indian population. Settings and Design: In a cross-sectional study, we assessed neurocognitive functioning in 40 unaffected first-degree relatives (FDR) of schizophrenia patients with an equal number of healthy controls. Materials and Methods: FDR schizophrenia group was compared with the control group on measures of short-term memory, verbal working memory, auditory verbal memory on indices of immediate recall and recognition, visuospatial working memory, visual attention, and executive functions. Results: The study found that FDR schizophrenia scored poorly on all tested measures of neurocognition except visual attention. On calculating composite score, we found that composite neurocognitive score better discriminated the FDR schizophrenia from the control group. Conclusions: Neurocognitive measures of short-term memory, verbal working memory, auditory verbal memory, visuospatial working memory, and executive functions significantly differentiate FDR of patients with schizophrenia from controls and can be considered as endophenotypic markers of schizophrenia in non-Caucasian population. The exactitude of this approach can be increased by calculating a composite neurocognitive score which combines various neurocognitive measures.
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- 2016
16. Psychiatric Correlates of Obesity in women and its impact on quality of life
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Aarti Midha, Abhay Paliwal, RK Solanki, Paramjeet Singh, and Mukesh Kumar Swami
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medicine.medical_specialty ,business.industry ,Overweight ,medicine.disease ,Obesity ,Malnutrition ,Clinical Psychology ,Psychiatry and Mental health ,Quality of life ,Chi-square test ,medicine ,medicine.symptom ,Psychiatry ,business ,Body mass index ,Depression (differential diagnoses) ,Psychopathology - Abstract
Byline: Ram. Solanki, Abhay. Paliwal, Paramjeet. Singh, Mukesh. Swami, Aarti. Midha To find out Sociodemographic profile of obese & overweight females and compare their psychiatric profile, eating behavior & quality of life. Methods and Material: The study was conducted at obesity clinic (specialty clinic) at SMS hospital, Jaipur. Females meeting the inclusion criteria were divided in 3 group obese, overweight & normal weight according to BMI. After collecting Sociodemographic data they were subjected to Hindi version of MHQ, Eating attitude test-26 & short form health survey. Statistical analysis used: mean, standard deviation, chi square test & ANOVA Results: In obese subjects, scores on subscale of MHQ were significantly different except for hysterical subscale. The obese females scored higher on EAT-26, showing more abnormal behavior. There was significant difference on all domains of quality of life except social functioning & role impairment due to emotional factors. Conclusions: Clinically obese and overweight females are vulnerable to psychological ill health. They also show different Sociodemographic characteristic, impaired quality of life and eating attitude. These aspects should be considered, so that obesity can be managed in a better way. Introduction Obesity, also called Corpulence, or Fatness, is defined as excessive accumulation of body fat, usually caused by the consumption of more calories than the body can use. [sup] [1] It is a condition of abnormal or excessive fat accumulation in adipose tissue, to the extent that the health may be impaired. [sup] [2] For adults, overweight and obesity ranges are determined by using weight and height to calculate the "body mass index" (BMI). BMI is used because, for most people, it correlates with their amount of body fat. The World Health Organization (WHO) defines "overweight" as a BMI equal to or more than 25, and "obesity" as a BMI equal to or more than 30. WHO's latest projections indicate that globally in 2005 approximately 1.6 billion adults (age 15+) were overweight & at least 400 million adults were obese. WHO further projects that by 2015, approximately 2.3 billion adults would be overweight and more than 700 million would be obese. [3] Recently conducted National Family Health Survey (NFHS)-3 has shown the problem of increasing proportion of overweight and obese, especially among women. Obesity among women is a growing problem in India, with the percentage of ever-married women age 15-49 who are overweight or obese increasing from 11 percent in NFHS-2 to 15 percent in NFHS-3. Overweight and obesity have become substantial problems among several groups of women in India, particularly older women, women living in urban areas, women who are well educated, women in households in the highest wealth quintile, and Sikhs. [sup] [4] Multiple factors influence weight, including genetic factors, endocrine levels, activity levels, metabolic rates, eating patterns, and stress. The distinctive way of life of a nation and the individual's behavioral and emotional reaction to it may contribute significantly to widespread obesity. The World Health Organization (WHO) has recognized obesity as a worldwide epidemic and paradoxically coexisting with undernutrition in both developing and industrialized countries.[sup] [5] The medical complications of overweight and obesity are known well. [sup] [6],[7],[8] The psychological correlates of carrying excess weight are documented less well. It is assumed that obesity is either a cause or a consequence of emotional disturbance or psychiatric disorder. Earlier it was conceptualized that obesity is the manifestation of underlying psychopathology and suboptimal development. [sup] [9] But the idea was not supported by further studies. Studies relating obesity and psychopathology have provided conflicting results, while some showing that the overweight experienced greater psychological distress, [sup] [10] other showed lower rates of psychiatric disorder at higher body weights. …
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- 2008
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17. Schizophrenia: Impact on quality of life
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RK Solanki, Aarti Midha, Paramjeet Singh, and Karan Chugh
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Quality of life ,medicine.medical_specialty ,Positive and Negative Syndrome Scale ,business.industry ,positive and negative syndrome scale ,Significant negative correlation ,medicine.disease ,Pearson product-moment correlation coefficient ,humanities ,Pharmacological treatment ,Correlation ,schizophrenia ,Psychiatry and Mental health ,symbols.namesake ,Schizophrenia ,symbols ,Social relationship ,medicine ,Original Article ,Psychiatry ,business ,Clinical psychology - Abstract
Aims : The purpose of the present study was to assess quality of life (QOL) in patients with schizophrenia and to determine influence of clinical factors and socio-demographic variables on QOL of schizophrenic patients. Setting and Design : Cross-sectional study carried out on outdoor patients attending Department of Psychiatry, SMS Medical College, Jaipur, India. Materials and Methods : Fifty patients of schizophrenia diagnosed as per ICD - 10 with minimum duration of illness being two years and attending out patient department (OPD) at psychiatric centre or psychiatric clinic at SMS medical college, hospital, Jaipur, India for maintenance treatment fulfilling the criteria given below were registered. They were evaluated using positive and negative syndrome scale (PANSS) and Quality of Life Instrument (WHO QOL - BREF). The data collected on above tools, was analyzed using descriptive and inferential statistics using Pearson correlation coefficient. Results and Conclusions: Patients were having lowest QOL scores in social relationships domain of WHO QOL - BREF scale. Social relationship domain of QOL was significantly negatively correlated with occupation with employed patients reporting better QOL in this domain. There were significant positive correlation of total monthly income with social relationship domain and total QOL. There were no statistically significant correlation between QOL parameters and clinical characteristics in schizophrenics. Scores on positive subscale and total PANSS were significantly negatively correlated with physical, Psychological, social relationship domains and total QOL. Negative subscale had significant negative correlation with physical and psychological domains and total QOL. General psychopathology subscale had significant negative correlation with all subscales of QOL. This study confirms poor QOL in schizophrenia despite significant improvement with pharmacological treatment.
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- 2008
18. A descriptive analysis of patients admitted in short stay ward at psychiatric centre, Jaipur, Rajasthan, India
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Parag Sharma, RK Solanki, Wasim, and Chitra Singh
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medicine.medical_specialty ,Descriptive statistics ,business.industry ,Socio demographics ,medicine.disease ,Positive correlation ,Substance abuse ,Short stay ,medicine ,Marital status ,In patient ,Social isolation ,medicine.symptom ,Psychiatry ,business - Abstract
Background: The average length of stay (LOS) at psychiatric centre and the factors determining longer LOS in Psychiatry disorders remains largely unexplored. Longer LOS is associated with social isolation and maladaptive behaviours in patients thus warrants a shorter stay. The observed LOS and predicted LOS among different psychiatry hospitals in future may serve as an index of quality care and efficient management of meagre but available resources in our country. The aim was (1) To study the socio demographic and clinical factors of patients admitted at our hospital and (2) To ascertain the relationship between the socio demographic, clinical factors and LOS.Methods: A retrospective analysis of psychiatry inpatients admitted at Psychiatric Centre, Jaipur during July 2014 and June 2015. The data was analysed studying the 489 case records. The socio demographic characteristics and clinical factors were correlated with LOS in hospital.Results: Our study has shown the correlation of socio-demographic factors and clinical factors with LOS. Rural population, marital status, employment status, number of episodes and diagnosis itself has positive correlation with longer LOS.Conclusions: From present study it was shown the correlation of socio-demographic factors and clinical profile with LOS. Rural population, marital status, premorbid employment status, number of episodes and diagnosis itself has positive correlation with longer LOS. However, gender and substance abuse had no correlation with LOS. Short term and planned admissions along with individualized treatment plans fitting patient’s social background may be more beneficial as compared to long term admissions.
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- 2017
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19. Adolescent onset Wilson's disease misdiagnosed as psychosis
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Dharamdeep Singh, Kishore Dudani, RK Solanki, and Pradeep K. Sharma
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0301 basic medicine ,Psychosis ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Head injury ,Not Otherwise Specified ,030105 genetics & heredity ,medicine.disease ,Irritability ,Wilson's disease ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Mood ,medicine ,Attention deficit hyperactivity disorder ,medicine.symptom ,Psychiatry ,Liver function tests ,business ,Letters to Editor ,030217 neurology & neurosurgery - Abstract
Byline: Kishore. Dudani, Ram. Solanki, Pradeep. Sharma, Dharamdeep. Singh Sir, Wilson's disease (WD) is a rare, treatable condition that can present as a diagnostic dilemma in clinical settings. It was first described in 1912 by Kinnear Wilson as “progressive lenticular degeneration,” a familial, lethal neurological syndrome accompanied by chronic liver disease.[sup][1] Clinically, it can present as liver disease, as progressive neurological entity, or as psychiatric illness. Majority of patients present between ages 5 and 35 years. Symptoms at any age are frequently nonspecific. Children may be entirely asymptomatic, with incidental findings of hepatic enlargement or abnormal serum aminotransferases. Neurological manifestations of WD mostly present in the third decade often later than the liver disease. Kayser–Fleischer (KF) rings are almost invariably present in patients with a neuropsychiatric presentation.[sup][2] Master M, 14-year-old Hindu boy, presented with 2 years illness of continuous course with chief complaints as marked disorganized behavior in the form of decreased interaction with family members, easy irritability, impaired self-care and daily routine along with disturbed sleep and appetite, and socio-occupational dysfunction. The boy stopped going to school and would be seen roaming around. At times, he would be found singing songs in public or behaving as if fighting with someone while alone. Suspiciousness in the form of fleeting persecutory delusions was reported. There had been no abdominal complaints. Following onset, he had been taken for consultation to many clinicians. The changing psychiatric diagnoses were made in the form of attention deficit hyperactivity disorder, bipolar affective disorder, psychosis not otherwise specified, and anxiety neurosis. Multiple psychotropics such as atomoxetine, mood stabilizers, antipsychotics, and benzodiazepines were used over time with minimal improvement. There had been no history of head injury, fits, or substance use. Family and development history were unremarkable. On examination, the boy was conscious and oriented. His psychomotor activity was somewhat raised with ill-sustained eye contact. Reaction time to reply was increased and dysarthria was present. At times, during the interview, he would be seen gazing at some point or would be mumbling intermittently. There was no rigidity or tremor or any other gross finding on general physical examination. Mini-mental state examination and higher mental functions could not be properly checked owing to poor attention. Liver function tests were gently raised which might have occurred due to prior psychotropics given or due to illness itself. …
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- 2016
20. Efficacy and tolerability of injectable sodium valproate in patients with mania
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RK Solanki, Paramjeet Singh, Renu Khandelwal, and Aarti Midha
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medicine.medical_specialty ,medicine.drug_class ,business.industry ,Brief Research Communication ,Sodium ,medicine.medical_treatment ,chemistry.chemical_element ,Mood stabilizer ,medicine.disease ,behavioral disciplines and activities ,Psychiatry and Mental health ,Mood ,Anticonvulsant ,chemistry ,Tolerability ,Internal medicine ,Anesthesia ,mental disorders ,medicine ,In patient ,Bipolar disorder ,medicine.symptom ,business ,Mania - Abstract
Background: Sodium valproate is among the newer mood stabilizers and is also an anticonvulsant. Aim To assess the effect of intravenous sodium valproate in patients with acute manic episodes of bipolar disorder. Methods: A 1-week open trial was conducted in the year 2004-2005 at the emergency ward of the Psychiatric Centre, SMS Medical College, Jaipur, in which 30 patients participated. Conclusion: Substantial improvement was seen. No major side-effects were noted except marginal elevation of the SGOT and SGPT. The findings suggest that injectable sodium valproate is a safe and effective mood stabilizer for patients with mania.
- Published
- 2006
21. An examination of relationship between neurological soft signs and neurocognition
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RK Solanki, Mukesh Kumar Swami, and Paramjeet Singh
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Primitive reflexes ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,Endophenotypes ,Audiology ,Neuropsychological Tests ,Young Adult ,Cognition ,Soft sign ,medicine ,Memory span ,Humans ,Family ,First-degree relatives ,Psychiatry ,General Psychology ,Aged ,Working memory ,Association Learning ,General Medicine ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Cross-Sectional Studies ,Memory, Short-Term ,Schizophrenia ,Female ,Schizophrenic Psychology ,Psychology ,Neurocognitive ,Psychomotor Performance - Abstract
Objective Neurological soft signs (NSS) and cognitive function had been examined in schizophrenia, but their relationship has remained elusive for several years. We examined the relationship between NSS and cognitive functions in the present study. Method A cross sectional study was carried out. Subjects were drawn from first degree relatives of schizophrenia patients, admitted as inpatient or attending as an outpatient. Controls were recruited by word of mouth from hospital staff and visitors of hospitalized patients. Those subjects who satisfied the screening process were subjected to Cambridge Neurological Inventory for soft sign assessment and digit span test, paired associate learning test (PALT) and visuo-spatial working memory matrix (VSWMM) for cognitive function assessment. Correlation analysis and structural equation modeling (SEM) was used for analysis. Result Significant negative correlation of primitive reflexes with PALT; of motor coordination with VSWMM, working memory (WM) and cognitive index; of total NSS with WM and cognitive index among first degree relatives. SEM showed that motor soft signs have important negative influence over WM. Conclusion The current findings indicate that NSS have significant negative effect on cognitive functioning.
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- 2011
22. BASICS OF MOLECULAR GENETIC MAPPING AND QTL ANALYSIS IN PLANTS
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Jitendra Kumar, Aditya Pratap, and RK Solanki
- Abstract
Genetic mapping refers to the determination of distance and order of genes/QTL on the chromosome. The conventional linkage analysis has been used to this purpose leading to publication of first genetic map of 6 sexlinked genes on a fruit fly chromosome. In plants, genetic linkage maps have been developed for major gene controlling the qualitative traits in several crops. However, the possibility of locating the QTL controlling the quantitative traits has also been investigated earlier using morphological traits as genetic markers. However, the advent of molecular markers has sped up the development of dense molecular maps and QTL analysis in crop plants. This led to the identification of QTL for desirable traits of agronomic importance. In this chapter, we discussed the basic principles of molecular genetic mapping and QTL analysis in plants.
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- 2009
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23. Problematic use of social networking sites among urban school going teenagers
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RK Solanki, Parth Singh Meena, and Pankaj Kumar Mittal
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Internet addiction ,teenagers ,Gratification ,lcsh:RC435-571 ,Cross-sectional study ,business.industry ,Addiction ,media_common.quotation_subject ,Internet privacy ,General Medicine ,Academic achievement ,Social web ,Popularity ,Social relation ,lcsh:Psychiatry ,Original Article ,social networking sites ,lcsh:Industrial psychology ,Social media ,Psychology ,business ,Social psychology ,lcsh:HF5548.7-5548.85 ,media_common - Abstract
Background: Social networking sites like Facebook, Orkut and Twitter are virtual communities where users can create individual public profiles, interact with real-life friends and meet other people based on shared interests. An exponential rise in usage of Social Networking Sites have been seen within the last few years. Their ease of use and immediate gratification effect on users has changed the way people in general and students in particular spend their time. Young adults, particularly teenagers tended to be unaware of just how much time they really spent on social networking sites. Negative correlates of Social Networking Sites usage include the decrease in real life social community participation and academic achievement, as well as relationship problems, each of which may be indicative of potential addiction. Aims: the aim of the study was to find out whether teenagers, specially those living in cities spend too much time on social networking websites. Materials and Methods: 200 subjects, both boys and girls were included in the cross sectional study who were given a 20 item Young's internet addiction test modified for social networking sites. The responses were analyzed using chi square test and Fisher's exact test. Results: 24.74% of the students were having occasional or ‘frequency’ problems while 2.02% of them were experiencing severe problems due to excessive time spent using social networking sites. Conclusion: With the ever increasing popularity of social media, teenagers are devoting significant time to social networking on websites and are prone to get ‘addicted’ to such form of online social interaction.
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- 2012
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24. Current perspectives in the treatment of resistant schizophrenia
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Deepti Munshi, RK Solanki, and Paramjeet Singh
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Olanzapine ,medicine.medical_specialty ,Risperidone ,clozapine ,business.industry ,Schizophrenia (object-oriented programming) ,Gold standard ,Review Article ,Adjuvant therapy ,treatment resistance ,Psychiatry and Mental health ,Adjunctive treatment ,medicine ,Treatment resistant schizophrenia ,Psychiatry ,business ,Clozapine ,medicine.drug - Abstract
This article summarizes the current knowledge base on the diagnosis and management of treatment resistant schizophrenia. While the prevalence of treatment resistant schizophrenia is definition dependent, estimates have ranged from 30% to up to 60%. This article first looks into the various diagnostic criteria of treatment resistant schizophrenia. Then the literature is reviewed about the pharmacotherapeutics of its management. Clozapine emerges to be the gold standard. In addition risperidone and high dose olanzapine also emerge as clinically useful options. Other emerging adjunctive treatment options are equally addressed.
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- 2009
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25. BIS-11A -Hindi version: A preliminary study of impulsivity in rural and urban Indian adolescents
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Paramjeet Singh, RK Solanki, and Priya Bhatnagar
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Hindi ,education.field_of_study ,Adolescent ,Population ,Poison control ,Context (language use) ,Impulsivity ,medicine.disease ,language.human_language ,Test (assessment) ,Developmental psychology ,Substance abuse ,Psychiatry and Mental health ,BIS-11 A ,language ,medicine ,Original Article ,rural ,Rural area ,medicine.symptom ,education ,Psychology ,urban ,Social psychology - Abstract
Context : Despite of there being a pressing need to gauge impulsivity scores, there is no behavioral instrument in India to assess the impulsivity in adolescents. No earlier studies have been done in India to access impulsivity in adolescents. Even in western countries, no study has been done in rural setting to access impulsivity, although segment of rural population is small in western nations with major population residing in urban areas. Aims : To translate BIS-11A into Hindi from English in a culturally sensitive manner and to do preliminary study in rural and urban areas. Settings and Design : First translation of BIS-11 (as it is meant for adults) and cultural substitution resulted in Hindi adult version. Adolescent version was derived from adult version by replacing adult activities with adolescent activities. Materials and Methods: BIS-11 English version was translated into Hindi and a back translation was made. As BIS-11 was developed for adults, answering some of the questions poses challenges for adolescents, so to be used with adolescents, questions that do not fit into adolescent age group were substituted keeping in view the activities of adolescents. Besides, questions that were not suitable as per the Indian culture were modified. Initially, these changes were made hypothetically by discussion among the authors and later a group of 48 school students were interviewed about the questions. Based on the interviews of students a final version was prepared. Translation, back translation, cultural substitution -hypothetically, and in school by discussion were carried out. The questionnaire was given to 120 urban high school students (in Jaipur, northern India) and 50 rural students (at Kanota, 25 km from Jaipur, northern India) and the scores were calculated as per the scoring method provided with original BIS-11. Statistical Analysis : T -test (two-tailed, two sample unequal variance, i.e., type 3) was used. Results : T -test (two-tailed, two sample unequal variance, i.e., type 3) found no significant difference between impulsivity scores of adolescents of urban and rural areas t 0.05(2)1 = 0.57, / t / 0.05, P = 12.706. There were no gender related differences either. Conclusions : As impulsivity can lead to suicide and is implicated for substance abuse in disorders like Schizophrenia, it is important that culturally sensitive impulsivity studies are done in India on a large scale keeping in view the large size of population. Standardization of the BIS11-A Hindi version is being taken up. The work on Hindi version also generates necessity for other tasks if BIS-11(Hindi version) is to be used widely. Work on psychometric properties of Hindi version of BIS-11 A is being taken up. There is a need to devise a quick way to calculate impulsivity scores keeping in view the large population of India (1 billion out of which at least 33% is Hindi speaking, Census Survey of India, 2001). Besides, BIS-11A needs to be developed for other regional languages in India as there is a high-linguistic diversity in India.
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- 2008
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26. Association of a novel begomovirus species with fenugreek yellow vein disease in India.
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Kumar M, Ghosh A, Jadon KS, Kaur B, Kakani RK, and Solanki RK
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- Phylogeny, DNA, Viral genetics, Sequence Analysis, DNA, India, Plant Diseases, Begomovirus genetics, Trigonella genetics, Fabaceae genetics
- Abstract
Background: Fenugreek (Trigonella foenum-graecum L.) is an annual medicinal and spice crop belonging to the family Fabaceae. The occurrence of a yellow vein disease was recorded in fenugreek in Jodhpur (India) in 2022. The infection of begomoviruses in legume crops results in significant yield loss and major economic loss. The current study reports an association of a novel begomovirus species associated with yellow vein disease in Fenugreek., Methods and Results: In symptomatic fenugreek plants, geminivirus-like particles were visible under a transmission electron microscope. Further, nucleotide sequence analysis of the rolling circle amplified product revealed 2743 nucleotide DNA-A genome with close relatedness to French bean leaf curl virus (88.21%) and Senna leaf curl virus (87.63%). It was proposed as a new begomovirus species, Fenugreek yellow vein Rajasthan virus. The genome organization suggested the presence of a typical nonanucleotide sequence along with 7 ORFs in DNA-A. A possible recombination event took place in the coat protein (V1) region with Pedilanthus leaf curl virus and Chilli leaf curl virus as major and minor parents. The recombinant virus poses possible threats to several other legume crops. To the best of our knowledge, this is the first report of the association of FeYVRaV with fenugreek yellow vein disease from northwestern India., Conclusions: In conclusion, the presence of a novel begomovirus species associated with yellow vein disease in fenugreek is alarming and needs further studies on its infectivity to prevent its spread to legume crops., (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2023
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27. Comparison of NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) as inflammatory markers in 1 st episode mania and bipolar mania: A preliminary study.
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Goyal MK, Solanki RK, Jain A, and Yadav KS
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Background: There are various factors including inflammation that have been studied in bipolar disorder. NLR (Neutrophil to lymphocyte ratio) and PLR (platelet to lymphocyte ratio) are one of them. Various psychotropic drugs can affect the inflammatory state., Aim: This study was planned to find NLR and PLR in bipolar disorder (mania) and psychotropic drug naïve 1
st episode mania., Materials and Methods: Total of 120 subjects were chosen including, 40 bipolar mania, 40 drugs naïve 1st episode mania, and 40 healthy controls. The severity of mania was assessed by the Young Mania Rating Scale. Blood samples were collected in the morning hours in order to get blood counts., Results: A significantly higher values of neutrophil counts and NLR, while the significant lower values of lymphocyte counts in both 1st episode and bipolar mania compared to healthy control were observed. The first episode mania group had significantly higher neutrophil counts and NLR in comparison to bipolar mania., Conclusion: Results suggest a possible inflammatory pathophysiology of mania. Psychotropic medicines may have an anti-inflammatory effect, signified by the fact that 1st episode mania group has a greater level of inflammation in comparison to bipolar mania., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Indian Journal of Psychiatry.)- Published
- 2023
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28. Study of Association of Various Psychiatric Disorders in Brain Tumors.
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Sharma A, Das AK, Jain A, Purohit DK, Solanki RK, and Gupta A
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Background Brain tumors may be associated with high morbidity, and psychiatric symptoms may be an early manifestation. It is important to address mental symptoms as early as possible because they are prone to develop psychiatric comorbidities in future. If untreated, these situations may worsen and lead to burden upon caregivers. Methods A total of 176 brain tumor patients between January 2021 and January 2022 constituted the sample size. All recently diagnosed cases of brain tumor with age equal to or more than 18 years who can comprehend and answer questionnaires were included. Patients with a long history of brain tumor or who had a history of a psychiatric illness other than presenting symptoms or any other serious medical illness were excluded. Results Twenty-seven percent of brain tumor patients had psychiatric symptoms. Depressive symptoms were the most common, associated with 24% of patients, followed by anxiety disorders. Psychiatric disorders were more common in supratentorial compared to infratentorial tumors. Psychiatric symptoms seem to be associated more commonly with malignant tumors and peritumoral edema. Among malignant tumors, depressive symptoms tend to be related with high-grade glioma, and among benign tumors, they were more common in meningioma. No predilection to laterality and anatomical lobe involvement is reported. Conclusion Screening of psychiatric disorders should be a routine in brain tumor patients. An integrated approach is required to treat brain tumor patients. Healthcare professionals should be more vigilant about the onset of psychiatric symptoms and the need of palliative care to improve the quality of life., Competing Interests: Conflicts of Interest None declared., (Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2022
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29. A Comparative Study of Analgesic Efficacy of Epidural Ropivacaine With Dexmedetomidine Versus Ropivacaine With Ketamine in Adult Patients Undergoing Elective Lower Limb Surgery.
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Gujral S, Singh B, Solanki RK, Babita B, Yadav S, Pipal RK, Pipal DK, and Pipal VR
- Abstract
Introduction: Adjuvating of the epidural block with local anaesthetics during lower limb surgeries improves Intraoperative as well as postoperative analgesia. A comparison of epidural ropivacaine plus dexmedetomidine (RD) versus ropivacaine plus ketamine (RK) was done in terms of quality of the motor and sensory blockade, changes in hemodynamic parameters, and efficacy of analgesia., Methods: A prospective randomized parallel double-blind study was conducted on 68 patients of the American Society of Anaesthesiologists (ASA) grade 1 and 2, ages 18 to 75 years, which were divided into two groups (RD and RK; 34 patients in each group). After receiving a loading dose through an epidural catheter consisting of 20ml of 0.5% ropivacaine, the epidural infusion was started after an hour of surgery at 5ml/hrs of 0.2% ropivacaine with 1µg/ml dexmedetomidine in Group RD and at 5ml/hrs of 0.2% ropivacaine with 0.5mg/ml ketamine in Group RK for 48 hours. Both groups were compared regarding the onset of sensory and motor block, resolution of sensory and motor block, hemodynamic parameters, analgesic efficacy, and total rescue analgesic requirement in 48 hours., Results: A significant difference was observed in the time of resolution of sensory blockade which was 9.77±2.38 hrs in the RD group as compared to 7.79±1.82 hrs in the RK group (p-value 0.0003) and the time of resolution of motor block was 6.53±2.44 hrs in the RD group compared to 4.58±0.83 hrs in the RK group (p-value 0.001)., Conclusions: Epidural dexmedetomidine significantly increases the duration of analgesia and duration of the motor blockade in comparison to ketamine., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Gujral et al.)
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- 2022
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30. A study of thyroid profile in patients suffering from the first episode of mania: A cross-sectional study.
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Goyal MK, Yadav KS, and Solanki RK
- Abstract
Background: Thyroid function is commonly considered in the assessment of mood disorders. Reports of thyroid dysregulation in patients with mania are associated with several confounding factors. To eliminate confounding factors, studies of first-episode mania are desirable. This study tried to find out any relationship between thyroid disorders and mania., Aim: The aim of this study is to assess and compare the thyroid profile between first-episode mania and healthy controls and to ascertain the correlation between severity and duration of the manic episode with FT3, FT4, and thyroid-stimulating hormone (TSH) levels., Materials and Methods: This was a cross-sectional study conducted in the psychiatry department of a tertiary care hospital. Forty consecutive drug-naïve patients with first-episode mania, diagnosed according to the International Classification of Disease-10 (study group), were matched with 40 healthy controls (control group). Both the groups were compared on the basis of thyroid profile and thyroid levels were correlated with duration and severity of illness in the study group., Results: Nearly 7.5% of cases in the study group had hyperthyroidism, whereas 5% had subclinical hyperthyroidism. In contrast, normal controls showed 5% and 10% prevalence of hypothyroidism and subclinical hypothyroidism, respectively. A statistically significant lower level of TSH was observed in the study group ( P < 0.001), whereas the mean serum levels of FT3 and FT4 were higher in the study group, but the difference was statistically nonsignificant. No significant correlation of thyroid hormones level with duration and severity of illness was noted., Conclusion: Our findings highlight a higher prevalence of hyperthyroidism in patients with mania and suggest the role of thyroid hormones in mania., Competing Interests: There are no conflicts of interest., (Copyright: © 2021 Indian Journal of Psychiatry.)
- Published
- 2021
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31. Development of psychiatry curriculum as a major subject during MBBS in India.
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Dhiman V, Krishnan V, Basu A, Das A, Rohilla J, Rawat VS, Nishchal A, Dave M, Solanki RK, Sahadevan S, Pal A, Garg S, Tikka SK, Dhyani M, Avinash P, Gupta M, Kant R, and Gupta R
- Abstract
Competing Interests: There are no conflicts of interest.
- Published
- 2021
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32. Factors Leading to Reverse Migration Among Migrant Workers During the COVID-19 Pandemic: A Multicenter Study From Northwest India.
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Chavan BS, Sidana A, Arun P, Rohilla R, Singh GP, Solanki RK, Aneja J, Murara MK, Verma M, Chakraborty S, Singh C, Sharma H, Sharma R, Bahri S, and Bhanwra D
- Subjects
- Adolescent, Adult, Aged, Communicable Disease Control, Cross-Sectional Studies, Female, Humans, India, Male, Middle Aged, Young Adult, COVID-19 prevention & control, Employment, Family, Health Knowledge, Attitudes, Practice, Transients and Migrants psychology
- Abstract
Objective: To examine the various psychosocial factors associated with reverse migration among migrant workers during the coronavirus disease 2019 (COVID-19) lockdown in India., Methods: A cross-sectional multicenter study was conducted at 4 sites in Northwest India. The migrant workers were recruited from various shelter homes, and information was gathered from reverse migrant workers and controls using various tools including a sociodemographic profile; knowledge, attitudes, and practices questionnaire; and reasons for migration and reverse migration questionnaires. A total of 275 reverse migrant workers and 276 controls participated in the study., Results: There was a considerable difference between reverse migrant workers and controls regarding the question of whether it was safe to travel during lockdown (76.0% vs 26.4%, respectively). The most common route of spread of COVID-19 infection was through touching and sneezing, and symptoms were fever, dry cough, and sore throat in both groups. Reverse migrant workers had low self-esteem and were reluctant to participate in customs of their migration city. A large number of reverse migrant workers reported that they had no money to survive, worried about family back home at their village, felt pressured by family members to come back to the village, and had been terminated from their job., Conclusions: Reverse migrant workers had the attitude that it was safe to travel during the lockdown. About one-fifth of the reverse migrant workers reported no place to live and fear of getting an infection. The reverse migrant workers also reported feeling low and gloomy, restless, and uncertain about the future and fear of death. Lack of jobs was a major factor driving migrant workers from their native homes., (© Copyright 2021 Physicians Postgraduate Press, Inc.)
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- 2021
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33. An adolescent with anorexia nervosa presenting with catatonia.
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Solanki RK, Khanna SK, Solanki G, Yadav KS, Agarwal R, and Goyal MK
- Abstract
Competing Interests: There are no conflicts of interest.
- Published
- 2021
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34. Anesthetic nuances in Segawa's syndrome: A case report and review of the literature.
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Kaur M, Sharma U, and Solanki RK
- Abstract
Segawa's syndrome, dopamine-responsive dystonia, is a rare genetic disorder that typically begins in childhood by around 4-6 years of age. It is characterized by abnormal gait and dystonia. A 33-year-old man presented for autologous skin grafting of a nonhealing wound under general anesthesia. Successful anesthetic management of patients with this rare disease, though analogous in many ways to that of patients with Parkinson's disease, still pose significant challenges. We present anesthetic nuances to be considered in the management of a patient with Segawa's disease along with a pertinent review of the literature., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Saudi Journal of Anesthesia.)
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- 2020
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35. COVID-19 pandemic: Psychological impact on anaesthesiologists.
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Jain A, Singariya G, Kamal M, Kumar M, Jain A, and Solanki RK
- Abstract
Background and Aim: The anaesthesiologists are at the highest risk of contracting infection of coronavirus disease 2019 (COVID-19) in emergency room, operation theatres and intensive care units. This overwhelming situation can make them prone for psychological stress leading to anxiety and insomnia., Materials and Methods: We did an online self-administered questionnaire-based observational cross-sectional study amongst anaesthesiologists across India. The objectives were to find out the main causes for anxiety and insomnia in COVID-19 pandemic. Generalised Anxiety Disorder-7 (GAD-7) scale and Insomnia Severity Index (ISI) were used for assessing anxiety and insomnia., Results: Of 512 participants, 74.2% suffered from anxiety and 60.5% suffered from insomnia. The age <35 years, female sex, being married, resident doctors, fear of infection to self or family, fear of salary deductions, increase in working hours, loneliness due to isolation, food and accommodation issues and posting in COVID-19 duty were risk factors for anxiety. ISI scores ≥8 was observed in <35 years, unmarried, those with stress because of COVID-19, fear of loneliness, issues of food and accommodation, increased working hours and with GAD-7 score ≥5. Adjusted odd's ratio of insomnia in participants having GAD-7 score ≥5 was 10.499 (95% confidence interval 6.097-18.080; P < 0.001)., Conclusion: The majority of anaesthesiologists on COVID-19 duty suffer from anxiety and insomnia. Addressing risk factors identified during this study with targeted interventions and psychosocial support will help them to cope better with the stress., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Indian Journal of Anaesthesia.)
- Published
- 2020
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36. Competency-based medical curriculum: Psychiatry, training of faculty, and Indian Psychiatric Society.
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Kishor M, Gupta R, Ashok MV, Isaac M, Chaddha RK, Singh OP, Shah H, Nishchal A, Dave M, Vinay Kumar HR, Das A, Rohilla JK, Singh PK, Kumar P, Swami M, Solanki RK, Sahadevan S, Pal A, Ray R, Garg S, Tikka SK, Dyanin M, Avinash P, Dhiman V, Basu A, Rawat VS, Krishnan V, Menon V, Chandran S, and Nebhinani N
- Published
- 2020
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37. Gender differences in obsessive-compulsive disorder: Findings from a multicentric study from India.
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Tripathi A, Avasthi A, Grover S, Sharma E, Lakdawala BM, Thirunavukarasu M, Dan A, Sinha V, Sareen H, Mishra KK, Rastogi P, Srivastava S, Dhingra I, Behere PB, Solanki RK, Sinha VK, Desai M, and Reddy YCJ
- Subjects
- Adolescent, Adult, Age of Onset, Aged, Comorbidity, Female, Hoarding Disorder epidemiology, Humans, India, Male, Middle Aged, Young Adult, Agoraphobia epidemiology, Obsessive-Compulsive Disorder epidemiology, Obsessive-Compulsive Disorder physiopathology, Sex Characteristics, Substance-Related Disorders epidemiology
- Abstract
Obsessive-compulsive disorder (OCD) is phenotypically heterogeneous. Gender is an important factor mediating this heterogeneity. We examined gender differences in a large sample (n = 945) of OCD patients under a multi-centric study in India. Cross-sectional assessments were done on consecutive adult (>18 years) treatment-seeking patients with a DSM-5 diagnosis of OCD. Subjects were assessed on Structured Clinical Interview for DSM-5-Research Version for comorbid psychiatric illnesses, Yale Brown Obsessive Compulsive Scale for OCD phenomenology and symptom severity, Brown Assessment of Beliefs Scale for insight, Beck's Depression Inventory for severity of depressive symptoms, and the Obsessive Beliefs Questionnaire. On multivariate backward Wald logistic regression analysis, males (59.7%) had more years of education, had a higher rate of checking compulsions and comorbid substance use disorders. Women were more likely to be married, more commonly reported precipitating factors, had a higher rate of hoarding compulsions and comorbid agoraphobia. Findings from this large study validate gender as an important mediator of phenotypic heterogeneity in OCD. The mechanistic basis for these differences might involve complex interactions between biological, cultural and environmental factors., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2018
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38. Serum Levels of Neuroactive Steroids in First-episode Antipsychotic-naïve Schizophrenic Patients and Its Correlation with Aggression: A Case-control Study.
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Solanki RK, Sharma P, Tyagi A, and Singh C
- Subjects
- Adolescent, Adult, Case-Control Studies, Dehydroepiandrosterone Sulfate blood, Female, Humans, Hydrocortisone blood, Hypothalamo-Hypophyseal System metabolism, Male, Middle Aged, Pituitary-Adrenal System metabolism, Sex Factors, Young Adult, Aggression psychology, Neurotransmitter Agents blood, Schizophrenia blood
- Abstract
Background: The evidence of hypothalamic-pituitary-adrenal axis dysfunction in schizophrenia has been reviewed in the context of the stress-diathesis model. Overactivation of this axis leads to altered blood levels of cortisol and dehydroepiandrosterone sulfate (DHEA-S). These neurosteroids in turn act on the hippocampus and interact with gamma-aminobutyric acid and N-methyl-D-aspartate receptors leading to neurotoxicity and may be involved in the neurobiology of aggression. This study aimed to explore the blood level of these neurosteroids and ascertain its correlation with state aggression and psychopathology in first-episode antipsychotic-naïve schizophrenic patients., Methods: A total of 30 patients with first-episode schizophrenia along with 20 age- and gender-matched healthy controls participated in the study. Both groups were subjected to serum cortisol and DHEA-S measurement after assessment of psychopathology and aggression on a standardised psychometric scale., Results: Serum DHEA-S level was significantly higher in the patient group (p = 0.001). No difference was noted between males and females in the patient group (p = 0.93) but female controls had a significantly lower serum DHEA-S level than male controls (p < 0.01). Serum DHEA-S inversely correlated with scores on Modified Overt Aggression Scale (p = 0.01) but not with Positive and Negative Syndrome Scale (p = 0.39) or Clinical Global Impression Scale (p = 0.28)., Conclusion: The first-episode antipsychotic-naïve schizophrenic patients showed a significantly higher blood level of DHEA-S compared with healthy controls. Serum DHEA-S level has an inverse relationship with aggression and may serve as a biological adaptive mechanism to antagonise the neuronal damage caused by cortisol.
- Published
- 2017
39. Adolescent onset Wilson's disease misdiagnosed as psychosis.
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Dudani K, Solanki RK, Sharma P, and Singh D
- Abstract
Competing Interests: There are no conflicts of interest.
- Published
- 2016
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40. An Indian experience of neurocognitive endophenotypic markers in unaffected first-degree relatives of schizophrenia patients.
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Solanki RK, Kumar A, Satija Y, Gupta S, and Singh P
- Abstract
Context: Multiple vulnerability genes interact with environmental factors to develop a range of phenotypes in the schizophrenia spectrum. Endophenotypes can help characterize the impact of risk genes by providing genetically relevant traits that are more complaisant than the behavioral symptoms that classify mental illness., Aims: We aimed to investigate the neurocognitive endophenotypic markers for schizophrenia in Indian population., Settings and Design: In a cross-sectional study, we assessed neurocognitive functioning in 40 unaffected first-degree relatives (FDR) of schizophrenia patients with an equal number of healthy controls., Materials and Methods: FDR schizophrenia group was compared with the control group on measures of short-term memory, verbal working memory, auditory verbal memory on indices of immediate recall and recognition, visuospatial working memory, visual attention, and executive functions., Results: The study found that FDR schizophrenia scored poorly on all tested measures of neurocognition except visual attention. On calculating composite score, we found that composite neurocognitive score better discriminated the FDR schizophrenia from the control group., Conclusions: Neurocognitive measures of short-term memory, verbal working memory, auditory verbal memory, visuospatial working memory, and executive functions significantly differentiate FDR of patients with schizophrenia from controls and can be considered as endophenotypic markers of schizophrenia in non-Caucasian population. The exactitude of this approach can be increased by calculating a composite neurocognitive score which combines various neurocognitive measures.
- Published
- 2016
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41. Identification of vulnerability among first-degree relatives of patients with schizophrenia.
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Solanki RK, Swami MK, Singh P, and Gupta S
- Subjects
- Adolescent, Adult, Aged, Cognition, Cognition Disorders psychology, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neurologic Examination psychology, Neuropsychological Tests statistics & numerical data, Personality Inventory statistics & numerical data, Psychiatric Status Rating Scales statistics & numerical data, Schizophrenia genetics, Schizotypal Personality Disorder diagnosis, Schizotypal Personality Disorder genetics, Early Diagnosis, Family psychology, Genetic Predisposition to Disease psychology, Schizophrenia diagnosis, Schizophrenic Psychology, Schizotypal Personality Disorder psychology
- Abstract
Objectives: To evaluate the status of schizotypy, neurological soft signs, and cognitive functions as vulnerability markers for schizophrenia and to investigate the potential value of their combination for early identification of people at high risk for schizophrenia., Methods: A cross-sectional study was conducted. Subjects were drawn from first-degree relatives of inpatients and outpatients with schizophrenia (n = 50). Controls (n = 30) were recruited by word-of-mouth from hospital staff and attendants of hospitalised patients. Subjects who met inclusion criteria on screening were subjected to selected measures for assessment, including Schizotypal Personality Questionnaire-Brief Version, the Cambridge Neurological Inventory, digit span test, paired associate learning test, and visuospatial working memory matrix. Statistical analysis was completed using the independent t test and significance (p value), as well as calculation of effect size (Cohen's d). Discriminant function analysis was used to determine the effect of combining assessment measures., Results: First-degree relatives showed higher schizotypy scores (Cohen's d = 0.88) and neurological soft signs (Cohen's d = 1.55). They scored significantly worse on all neurocognitive measures (Cohen's d = -1.27). Discriminant function analysis showed that Schizotypal Personality Questionnaire-Brief Version, neurological soft signs, and total cognitive index (the sum of weighted scores on individual cognitive scales) in combination better discriminated between the first-degree relative and control groups (Wilks' λ = 0.54)., Conclusion: Use of multiple vulnerability markers could enhance the specificity of measures used to determine risk for schizophrenia.
- Published
- 2012
42. An examination of relationship between neurological soft signs and neurocognition.
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Solanki RK, Swami MK, and Singh P
- Subjects
- Adolescent, Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Young Adult, Association Learning, Cognition, Endophenotypes, Family, Memory, Short-Term, Schizophrenia, Schizophrenic Psychology
- Abstract
Objective: Neurological soft signs (NSS) and cognitive function had been examined in schizophrenia, but their relationship has remained elusive for several years. We examined the relationship between NSS and cognitive functions in the present study., Method: A cross sectional study was carried out. Subjects were drawn from first degree relatives of schizophrenia patients, admitted as inpatient or attending as an outpatient. Controls were recruited by word of mouth from hospital staff and visitors of hospitalized patients. Those subjects who satisfied the screening process were subjected to Cambridge Neurological Inventory for soft sign assessment and digit span test, paired associate learning test (PALT) and visuo-spatial working memory matrix (VSWMM) for cognitive function assessment. Correlation analysis and structural equation modeling (SEM) was used for analysis., Result: Significant negative correlation of primitive reflexes with PALT; of motor coordination with VSWMM, working memory (WM) and cognitive index; of total NSS with WM and cognitive index among first degree relatives. SEM showed that motor soft signs have important negative influence over WM., Conclusion: The current findings indicate that NSS have significant negative effect on cognitive functioning., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
43. Disability and quality of life in schizophrenia and obsessive compulsive disorder: a cross-sectional comparative study.
- Author
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Solanki RK, Singh P, Midha A, Chugh K, and Swami MK
- Abstract
Objective: To assess and compare the quality of life and disability in patients with schizophrenia and obsessive compulsive disorder., Methods: A cross-sectional study was carried out in the outpatient psychiatry clinics at Jaipur of India. Fifty patients with obsessive compulsive disorder and 47 with schizophrenia (diagnosed as per criteria of the 10th revision of the International Classification of Diseases), and with a minimum duration of 2 years on maintenance treatments, were evaluated. Evaluation was based on the World Health Organization Quality of Life Instrument, the Global Assessment of Functioning scale, and the Indian Disability Evaluation Assessment Scale. The collected data were analysed using descriptive and inferential statistics., Results: Regarding quality of life domains, there was no statistically significant difference between the 2 groups. Obsessive compulsive disorder patients had lower scores on all domains of disability, all such differences being statistically significant., Conclusions: The deleterious effect of illness on quality of life and functioning occur not only in schizophrenic but also in obsessive compulsive disorder patients. Thus management should be planned with this consideration to yield better outcomes in both conditions.
- Published
- 2010
44. Neurocognitive impairment and comorbid depression in patients of diabetes mellitus.
- Author
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Solanki RK, Dubey V, and Munshi D
- Abstract
This study was conducted to find out the association of diabetes mellitus with cognitive functioning and depressive features. We included 50 diabetic and 30 control subjects who were screened on the basis of various inclusion and exclusion criteria. Then, a history of variables under study was taken and respective laboratory investigations were noted. First, the Becks Depression Inventory (BDI) was administrated to the patients. The cognitive function was then assessed using the digit span test, stroop Test, controlled oral word association test, visual target cancellation test, digit symbol substitution test, and visuospatial working memory matrix. The composite score on all tests was used to make cognitive index. The data was compiled and appropriate statistical methods were used. We found that 48% of elderly diabetic patients showed cognitive impairment. Poor metabolic control (hyperglycemia) was associated significantly and negatively with cognitive index in diabetic patients. Hyperglycemia was significantly and negatively correlated with immediate memory and attention, verbal memory, psychomotor functioning (DSST), and visuospatial memory. In conclusion, genesis of cognitive deficits in diabetic patients is complex. However, it appears from the study that such deficits do exist and may be associated with chronically poorly controlled diabetes.
- Published
- 2009
- Full Text
- View/download PDF
45. Schizophrenia: Impact on quality of life.
- Author
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Solanki RK, Singh P, Midha A, and Chugh K
- Abstract
Aims: The purpose of the present study was to assess quality of life (QOL) in patients with schizophrenia and to determine influence of clinical factors and socio-demographic variables on QOL of schizophrenic patients., Setting and Design: Cross-sectional study carried out on outdoor patients attending Department of Psychiatry, SMS Medical College, Jaipur, India., Materials and Methods: Fifty patients of schizophrenia diagnosed as per ICD - 10 with minimum duration of illness being two years and attending out patient department (OPD) at psychiatric centre or psychiatric clinic at SMS medical college, hospital, Jaipur, India for maintenance treatment fulfilling the criteria given below were registered. They were evaluated using positive and negative syndrome scale (PANSS) and Quality of Life Instrument (WHO QOL - BREF). The data collected on above tools, was analyzed using descriptive and inferential statistics using Pearson correlation coefficient., Results and Conclusions: Patients were having lowest QOL scores in social relationships domain of WHO QOL - BREF scale. Social relationship domain of QOL was significantly negatively correlated with occupation with employed patients reporting better QOL in this domain. There were significant positive correlation of total monthly income with social relationship domain and total QOL. There were no statistically significant correlation between QOL parameters and clinical characteristics in schizophrenics. Scores on positive subscale and total PANSS were significantly negatively correlated with physical, Psychological, social relationship domains and total QOL. Negative subscale had significant negative correlation with physical and psychological domains and total QOL. General psychopathology subscale had significant negative correlation with all subscales of QOL. This study confirms poor QOL in schizophrenia despite significant improvement with pharmacological treatment.
- Published
- 2008
- Full Text
- View/download PDF
46. Blood pressure is associated with cognitive impairment in young hypertensives.
- Author
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Gupta R, Solanki RK, and Pathak V
- Subjects
- Adrenergic beta-Antagonists adverse effects, Adrenergic beta-Antagonists therapeutic use, Adult, Analysis of Variance, Calcium Channel Blockers adverse effects, Calcium Channel Blockers therapeutic use, Cognition drug effects, Cognition Disorders diagnosis, Female, Humans, Hypertension drug therapy, Male, Memory Disorders diagnosis, Memory Disorders epidemiology, Middle Aged, Neuropsychological Tests, Patient Compliance statistics & numerical data, Perceptual Disorders diagnosis, Perceptual Disorders epidemiology, Severity of Illness Index, Space Perception, Trail Making Test, Visual Perception, Cognition Disorders epidemiology, Hypertension epidemiology
- Abstract
Aims: The present study was conducted to assess the effects of duration of hypertension, systolic hypertension, diastolic hypertension, drug compliance and class-of-drug on cognitive functions., Methods and Results: A cohort of young hypertensive subjects was recruited after obtaining informed consent. Subjects with confounding factors, e.g., substance use, neurological disorders, endocrinopathies, inflammatory conditions, psychiatric illnesses, etc., were excluded. Their average systolic and diastolic blood pressure since onset of illness and prescribed drugs were noted from the records. Compliance was assessed with the help of information from subjects as well as the close relatives. MMSE and a battery of neuropsychological tests (Digit Span Test, Trail Making Test Form B, Stroop Test, Visuospatial Working Memory Matrix and Word Fluency Test) was applied to all the participants. Multivariate regression analysis was used for the assessment of associations and one-way ANOVA was performed to assess differences in the mean. Analysis showed that mean age of study subject was 52 years and average duration of hypertension was 9 years. Fourteen percent subjects had obvious cognitive impairment as suggested by MMSE score less than 23. However, when cut-off score was lowered to 20, only 6% subjects fell into this category. Diastolic blood pressure had significant negative association with all of the cognitive measures except Trail Making Test, which was, on the contrary, significantly and negatively associated with systolic blood pressure. Duration of hypertension did not influence cognitive performance in this study. Effect of drug compliance was somewhat variable, but in general good compliance was associated with better cognitive performance. Beta-Blocker therapy hampered cognitive performance, whereas the best performance, especially on tests of semantic memory and pre-frontal functions was seen in subjects taking calcium channel blockers., Conclusions: Diastolic hypertension was associated with significant impairment of cognitive functions in younger subjects. On the other hand good compliance and calcium channel blockers had protective effect on hypertension induced cognitive impairment, especially on the prefrontal functions.
- Published
- 2008
- Full Text
- View/download PDF
47. Clozapine: Current perspective.
- Author
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Solanki RK, Singh P, and Swami MK
- Abstract
The author conducted a review of studies that compared the efficacy, tolerability and indication for the use of clozapine in current perspectives for the treatment of resistant schizophrenia/ partial responders.
- Published
- 2007
- Full Text
- View/download PDF
48. Association of hypertension and its treatment with dementia and cognitive functioning.
- Author
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Gupta R, Solanki RK, Midha P, Dubey V, and Pathak V
- Subjects
- Adult, Blood Pressure physiology, Cognition physiology, Comorbidity, Dementia prevention & control, Female, Humans, Hypertension drug therapy, Male, Middle Aged, Dementia epidemiology, Hypertension epidemiology
- Abstract
Aim: Hypertension is known to induce many pathological changes in the body, including cardiac hypertrophy, atherosclerosis, micro-aneurisms and stroke. Besides these conspicuous pathologies, it also has subtle effects on the functioning of the brain. These cognitive changes have received little attention despite the fact that they make a large impact on the daily functioning of affected persons. The present study was conducted to assess the effect of hypertension and related factors on cognitive functions in an Indian population., Methods and Results: A cohort of young hypertensive subjects was recruited after obtaining informed consent. Subjects with confounding factors, such as substance use, neurological disorders, endocrinopathies, inflammatory conditions and psychiatric illnesses, were excluded. The average systolic and diastolic blood pressure of the subjects since the onset of illness and prescription of drugs were noted from the records. Compliance was assessed with the help of information given by the subjects and their close relatives. The mini-mental state examination and a battery of neuropsychological tests (digit span test, trail making test, Stroop test, visuospatial working memory matrix and word fluency test) were applied to all participants. Univariate regression analysis was used for the assessment of association and a one-way analysis of variance was performed on categorical variables. The mean age of the subjects was 52 years, and the average duration of hypertension 9 years. Twelve subjects had dementia which could be attributed to the subtle effects of hypertension only. Blood pressure (both systolic and diastolic) had a significant negative association with the cognitive tests. Cognitive impairment was also seen in subjects who reported poor drug compliance and those using beta blockers, while calcium channel blockers played a protective role., Conclusions: Hypertension was associated with a significant decline in cognitive functioning in younger subjects. Good compliance with drugs and the use of calcium channel blockers had a protective effect on hypertension-induced cognitive decline.
- Published
- 2006
49. Efficacy and tolerability of injectable sodium valproate in patients with mania.
- Author
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Solanki RK, Singh P, Khandelwal R, and Midha A
- Abstract
Background: Sodium valproate is among the newer mood stabilizers and is also an anticonvulsant., Aim: To assess the effect of intravenous sodium valproate in patients with acute manic episodes of bipolar disorder., Methods: A 1-week open trial was conducted in the year 2004-2005 at the emergency ward of the Psychiatric Centre, SMS Medical College, Jaipur, in which 30 patients participated., Conclusion: Substantial improvement was seen. No major side-effects were noted except marginal elevation of the SGOT and SGPT. The findings suggest that injectable sodium valproate is a safe and effective mood stabilizer for patients with mania.
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- 2006
- Full Text
- View/download PDF
50. Is hysteria still prevailing? A retrospective study of sociodemographic and clinical characteristics.
- Author
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Jain A, Verma KK, Solanki RK, and Sidana A
- Subjects
- Adolescent, Adult, Aphonia epidemiology, Aphonia etiology, Child, Comorbidity, Female, Humans, India epidemiology, Male, Prevalence, Retrospective Studies, Sex Distribution, Socioeconomic Factors, Unconsciousness epidemiology, Hysteria epidemiology
- Abstract
A retrospective study was conducted in a psychiatric setup of S.P. Medical College, Bikaner (Raj.) to assess the social demographic and clinical characteristics of hysterical patients. The illness was more common in female patients. Most of the patients were young, married and illiterate. Nearly half of them had faced some stress prior to onset of their illness. Fits of unconsciousness and aphonia were the commonest presentation in female and male patients respectively. Duration of stay was 2-3 days and most of the patient responded well to different treatment modalities.
- Published
- 2000
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