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348 results on '"RICHTER GM"'

1. Peripapillary microvasculature in the retinal nerve fiber layer in glaucoma by optical coherence tomography angiography: focal structural and functional correlations and diagnostic performance

Author

Richter GM, Sylvester B, Chu Z, Burkemper B, Madi I, Chang R, Reznik A, Varma R, and Wang RK

Subjects
optical coherence tomography angiography, glaucoma, structure, function, microcirculation, diagnostic accuracy, Ophthalmology, RE1-994
Abstract

Grace M Richter,1,* Beau Sylvester,1,* Zhongdi Chu,2 Bruce Burkemper,1 Ingy Madi,1 Ryuna Chang,1 Alena Reznik,1 Rohit Varma,1 Ruikang K Wang2 1Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA; 2Department of Bioengineering, University of Washington, Seattle, WA, USA *These authors contributed equally to this work Purpose: To quantify peripapillary microvasculature within the retinal nerve fiber layer (RNFL) in primary open-angle glaucoma (POAG) and normal eyes, determine association of perfusion parameters with structural and functional measures, and report diagnostic accuracy of perfusion parameters.Patients and methods: POAG and normal patients underwent 6×6 mm2 optic nerve head scans (Angioplex optical coherence tomography angiography [OCTA]; Cirrus HD-OCT 5000) and Humphrey Field Analyzer II-i 24-2 visual field (VF) testing. Prototype software performed semiautomatic segmentation to create RNFL en face images and quantified vessel area density (VAD), vessel skeleton density (VSD), and vessel complexity index (VCI) in the optic nerve head globally and focally. Generalized estimating equations models assessed association of OCTA parameters with VF mean deviation (MD) and RNFL thickness.Results: Thirty-eight POAG and 17 normal eyes were studied. Global VAD, VSD, and VCI were reduced in mild POAG vs normal (P

Published
2018

2. Minimally invasive glaucoma surgery: current status and future prospects

Author

Richter GM and Coleman AL

Subjects
minimally invasive glaucoma surgery, microincisional glaucoma surgery, Ophthalmology, RE1-994
Abstract

Grace M Richter,1,2 Anne L Coleman11UCLA Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA, USA; 2USC Eye Institute, Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USAAbstract: Minimally invasive glaucoma surgery aims to provide a medication-sparing, conjunctival-sparing, ab interno approach to intraocular pressure reduction for patients with mild-to-moderate glaucoma that is safer than traditional incisional glaucoma surgery. The current approaches include: increasing trabecular outflow (Trabectome, iStent, Hydrus stent, gonioscopy-assisted transluminal trabeculotomy, excimer laser trabeculotomy); suprachoroidal shunts (Cypass micro-stent); reducing aqueous production (endocyclophotocoagulation); and subconjunctival filtration (XEN gel stent). The data on each surgical procedure for each of these approaches are reviewed in this article, patient selection pearls learned to date are discussed, and expectations for the future are examined. Keywords: MIGS, microincisional glaucoma surgery, trabecular stent, Schlemm’s canal, suprachoroidal shunt, ab interno

Published
2016

4. Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus

Author

Munz, M, Richter, GM, Loos, BG, Jepsen, S, Divaris, K, Offenbacher, S, Teumer, A, Holtfreter, B, Kocher, T, Bruckmann, C, Jockel-Schneider, Y, Graetz, C, Munoz, L, Bhandari, A, Tennstedt, S, Staufenbiel, I, van der Velde, Nathalie, Uitterlinden, André, Groot, L, Wellmann, J, Berger, K, Krone, B, Hoffmann, P, Laudes, M, Lieb, W, Franke, A, Dommisch, H, Erdmann, J, Schaefer, AS, Munz, M, Richter, GM, Loos, BG, Jepsen, S, Divaris, K, Offenbacher, S, Teumer, A, Holtfreter, B, Kocher, T, Bruckmann, C, Jockel-Schneider, Y, Graetz, C, Munoz, L, Bhandari, A, Tennstedt, S, Staufenbiel, I, van der Velde, Nathalie, Uitterlinden, André, Groot, L, Wellmann, J, Berger, K, Krone, B, Hoffmann, P, Laudes, M, Lieb, W, Franke, A, Dommisch, H, Erdmann, J, and Schaefer, AS

Published
2018

5. A tumour score with multidetector spiral CT for venous infiltration in pancreatic cancer: influence on borderline resectable

Author

Marinelli, T, Filippone, A, Tavano, F, Fontana, A, Pellegrini, F, Köninger, J, Richter, Gm, Bonomo, Lorenzo, Büchler, Mw, Di Sebastiano, P, Di Mola, Ff, Bonomo, Lorenzo (ORCID:0000-0001-5101-9367), Marinelli, T, Filippone, A, Tavano, F, Fontana, A, Pellegrini, F, Köninger, J, Richter, Gm, Bonomo, Lorenzo, Büchler, Mw, Di Sebastiano, P, Di Mola, Ff, and Bonomo, Lorenzo (ORCID:0000-0001-5101-9367)

Abstract

A tumour score for venous invasion in patients with pancreatic adenocarcinoma was evaluated by means of computed tomography (CT), in order to improve the assessment of medical treatment and clinical outcome with special attention to borderline resectable disease.

Published
2014

6. Wall Shear Stress simulations in a CT based human abdominal aortic model

Author

Hazer, D, Unterhinninghofen, R, Kostrzewa, M, Kauczor, HU, Dillmann, R, and Richter, GM

Subjects
ddc: 610, cardiovascular system, abdominal aorta, computational fluid dynamics, finite volume method (FVM), wall shear stress, CT/MRI, circulatory and respiratory physiology
Abstract

Abnormal Wall Shear Stress (WSS) distributions may be a predictor for the risk of development or rupture of an aneurysm and a tool to control the efficiency of the therapy. In this work, we present a method for the computation of WSS based on Computational Fluid Dynamics (CFD) simulations. The approach is applied to a CT based abdominal aortic model and realistic boundary conditions are considered based on MR flow measurements. WSS simulations are computed using the CFD program Fluent. The simulation results show realistic mean WSS distributions and provide a quantitative description of the stress conditions in the aortic model. The mean range of the computed values is compatible with that obtained by other in vivo and in vitro methods , . The method provides a numerical approach for the computation of WSS. However, further development and validation should be investigated in order to reach computations that can be implemented clinically.

Published
2007

8. Comparison of 1.0 M gadobutrol and 0.5 M gadopentate dimeglumine-enhanced MRI in 471 patients with known or suspected renal lesions: results of a multicenter, single-blind, interindividual, randomized clinical phase III trial

Author

Tombach, B, Bohndorf, K, Brodtrager, W, Claussen, CD, Duber, C, Galanski, M, Grabbe, E, Gortenuti, G, Kuhn, M, Gross-Fengels, W, Hammerstingl, R, Happel, B, Heinz-Peer, G, Jung, G, Kittner, T, Lagalla, R, Lengsfeld, P, Loose, R, Oyen, RHG, Pavlica, P, Pering, C, Pozzi-Mucelli, R, Persigehl, T, Reimer, P, Renken, NS, Richter, GM, Rummeny, EJ, Schafer, F, Szczerbo-Trojanowska, M, Urbanik, A, Vogl, TJ, Hajek, P, Tombach, B, Bohndorf, K, Brodtrager, W, Claussen, CD, Duber, C, Galanski, M, Grabbe, E, Gortenuti, G, Kuhn, M, Gross-Fengels, W, Hammerstingl, R, Happel, B, Heinz-Peer, G, Jung, G, Kittner, T, Lagalla, R, Lengsfeld, P, Loose, R, Oyen, RHG, Pavlica, P, Pering, C, Pozzi-Mucelli, R, Persigehl, T, Reimer, P, Renken, NS, Richter, GM, Rummeny, EJ, Schafer, F, Szczerbo-Trojanowska, M, Urbanik, A, Vogl, TJ, and Hajek, P

Abstract

The purpose of this phase III clinical trial was to compare two different extracellular contrast agents, 1.0 M gadobutrol and 0.5 M gadopentate dimeglumine, for magnetic resonance imaging (MRI) in patients with known or suspected focal renal lesions. Using a multicenter, single-blind, interindividual, randomized study design, both contrast agents were compared in a total of 471 patients regarding their diagnostic accuracy, sensitivity, and specificity to correctly classify focal lesions of the kidney. To test for noninferiority the diagnostic accuracy rates for both contrast agents were compared with CT results based on a blinded reading. The average diagnostic accuracy across the three blinded readers ('average reader') was 83.7% for gadobutrol and 87.3% for gadopentate dimeglumine. The increase in accuracy from precontrast to combined precontrast and postcontrast MRI was 8.0% for gadobutrol and 6.9% for gadopentate dimeglumine. Sensitivity of the average reader was 85.2% for gadobutrol and 88.7% for gadopentate dimeglumine. Specificity of the average reader was 82.1% for gadobutrol and 86.1% for gadopentate dimeglumine. In conclusion, this study documents evidence for the noninferiority of a single i.v. bolus injection of 1.0 M gadobutrol compared with 0.5 M gadopentate dimeglumine in the diagnostic assessment of renal lesions with CE-MRI.

Published
2008

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