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Purpose: To investigate the capacity of chat-generative pre-trained transformer (Chat-GPT) to understand the S2k guideline of the German Society for Gynecology and Obstetrics on intrauterine growth restriction. Methods: The German-language free Chat-GPT version was used to test the ability of Chat-GPT to understand the definition of small for gestational age and intrauterine growth restriction, to indicate the correct time and place of delivery and to evaluate ist ability to recommend a spontaneous delivery versus a primary caesarean section in accordance with the guideline recommendations. In order to objectively evaluate the suggestions a simple three-color 'traffic light' evaluation system was employed. Results: Almost all Chat-GPT's suggestions in the context of definition of small for gestational age/intrauterine growth restriction as well as correct time of delivery were adequate, whereas more than half of the suggestions made in terms of correct delivery mode needed reformulation or even correction. Conclusion: Chat-GPT appears to be a valuable form of artificial intelligence that could be integrated into everyday clinical practice. [ABSTRACT FROM AUTHOR]

The long‐term effects of COVID‐19 on lung function are not understood, especially for periods extending beyond 1 year after infection. This observational, longitudinal study investigated lung function in Mexican Hispanics who experienced severe COVID‐19, focusing on how the length of recovery affects lung function improvements. At a specialized COVID‐19 follow‐up clinic in Yucatan, Mexico, lung function and symptoms were assessed in patients who had recovered from severe COVID‐19. We used z‐scores, and Wilcoxon's signed rank test to analyse changes in lung function over time. Lung function was measured twice in 82 patients: the first and second measurements were taken a median of 94 and 362 days after COVID‐19 diagnosis, respectively. Initially, 61% of patients exhibited at least one of several pulmonary function abnormalities (lower limit of normal = –1.645), which decreased to 22% of patients by 390 days post‐recovery. Considering day‐to‐day variability in lung function, 68% of patients showed improvement by the final visit, while 30% had unchanged lung function from the initial assessment. Computed tomography (CT) scans revealed ground‐glass opacities in 33% of patients. One year after infection, diffusing capacity of the lungs for carbon monoxide z‐scores accounted for 30% of the variation in CT fibrosis scores. There was no significant correlation between the length of recovery and improvement in lung function based on z‐scores. In conclusion, 22% of patients who recovered from severe COVID‐19 continued to show at least one lung function abnormality 1 year after recovery, indicating a prolonged impact of COVID‐19 on lung health. [ABSTRACT FROM AUTHOR]

We show herein that 1,10‐dicyano substitution restricts the paragon fluxionality of bullvalene to just 14 isomers which isomerize along a single cycle. The restricted fluxionality of 1,10‐dicyanobullvalene (DCB) is investigated by means of: (i) Bonding analyses of the isomer structures using the adaptive natural density partitioning (AdNDP). (ii) Quantum dynamical simulations of the isomerizations along the cyclic intrinsic reaction coordinate of the potential energy surface (PES). The PES possesses 14 equivalent potential wells supporting 14 isomers which are separated by 14 equivalent potential barriers supporting 14 transition states. Accordingly, at low temperatures, DCB appears as a hindered molecular rotor, without any delocalization of the wavefunction in the 14 potential wells, without any nuclear spin isomers, and with completely negligible tunneling. These results are compared and found to differ from those for molecular boron rotors. (iii) Born‐Oppenheimer molecular dynamics (BOMD) simulations of thermally activated isomerizations. (iv) Calculations of the rate constants in the frame of transition state theory (TST) with reasonable agreement achieved with the BOMD results. (v) Simulations of the equilibration dynamics using rate equations for the isomerizations with TST rate coefficients. Accordingly, in the long‐time limit, isomerizations of the 14 isomers, each with Cs symmetry, approach the "14 Cs → C7v" thermally averaged structure. This is a superposition of the 14 equally populated isomer structures with an overall C7v symmetry. By extrapolation, the results for DCB yield working hypotheses for so far un‐explored properties e.g. for the equilibration dynamics of C10H10. [ABSTRACT FROM AUTHOR]

For a locally compact group G and 1 < p < ∞ , let B p (G) denote the p-analog of the Fourier–Stieltjes algebra B (G) (or B 2 (G)) . Let r : B p (G) → B p (H) be the restriction map given by r (u) = u | H for any closed subgroup H of G. In this article, we prove that the restriction map r is a surjective isometry for any open subgroup H of G. Further, we show that the range of the map r is dense in B p (H) when H is either a compact normal subgroup of G or compact subgroup of an [SIN] H -group. [ABSTRACT FROM AUTHOR]

Abstract Unhealthy products (food, alcohol, tobacco) are among the main risk factors of non-communicable diseases. To discourage the consumption of these products, Iran has passed a law banning the advertisement of unhealthy products in all media and for all age groups. The purpose of the present study was to identify the challenges of this approach and provide evidence to facilitate the enforcement process and the participation of stakeholders. In this qualitative study participants were selected from the policymakers and experts involved in the banning of advertisements on unhealthy products in Iran. Semi-structured interviews were conducted with 24 specialists and experts. The participants were selected through purposive and snowball sampling. Identified challenges and solutions were divided into three categories and nine themes: external (political, social, and economic); interorganizational (mission and communication); and internal (planning, organization, leadership, and control). Banning the advertisement of unhealthy products involves many challenges due to the existence of key players with different roles and missions. If these challenges are not managed effectively, they will hinder the enforcement and success of this law. Therefore, it is necessary for policymakers and health system managers to take the necessary measures to remove these obstacles.

This paper aims to study the concept of brotherhood in the Holy Qurʾān, classify brotherhood in Qurʾānic texts into faith-based brotherhood, as well as tribal and national brotherhood, and its other meanings, and clarify that restriction of brotherhood to the circle of faith in the Qurʾānic text does not prevent the use of the word in its other linguistic and conventional meanings of human brotherhood, national brotherhood, and patriotic brotherhood. In doing so, it relies on the style of the Qurʾānic Arabic language in restriction with the exclusive conjunction "innamā", the semantic aspects of the word "brother" in the Qurʾān according to the traditional Qurʾānic science of polysemes (“ʿilm al-Wujūh wa an-Naẓā'ir”), the study of the word's occurrences in the Qurʾān and the classification of its semantic aspects in those occurrences, and in accordance with what the scholars of the principles of jurisprudence have decided on the division of words in position and use into linguistic, customary, and legal, and the role of the Qurʾānic context in clarifying the meaning of the Qurʾānic text. The research ultimately aims to clarify the role of Qurʾānic and linguistic sciences in correct guidance and disciplined interpretation of the Qurʾān's intentions behind its words and statements and to absolve these intentions of attempts to employ the texts for tendencies of bigotry, discrimination, and hatred.

Infection is inconceivable without T cells. T cells not only eliminate virus-infected cells and participate in the formation of immunological memory, but also indirectly modulate the humoral response through the selection and maintenance of specific B cells. The T-cell receptor (TCR) recognizes processed antigen presented on the surface of cells in the MHC of one of two classes. Thus, the formed TCR repertoire reflects the history of encountered antigens through the prism of the specific organism with a particular set of MHC. To investigate changes in the TCR repertoire in response to acute viral infection, we utilized a yellow fever vaccination model. The yellow fever vaccine has been a benchmark for both safety and efficacy for over half a century. The vaccine is based on a live attenuated virus, allowing the study of the immune response under conditions closely to the viral infection. The yellow fever-specific T-cell response to immunodominant peptides presented on HLA-A02 is well studied, but experiments with HLA-A02-negative donors are still lacking. The aim of this study was to examine the dynamics of changes in the T-cell repertoire structure that occur in response to yellow fever vaccination in a donor without the HLA-A02 allele. We found that the overall T-cell response dynamics were similar to that in HLA-A02-positive donors: vaccination led to rapid expansion of yellow fever-reactive clones by day 14. Despite the absence of a known immunodominant epitope for HLA I alleles in this donor, the immune response also shifted towards CD8⁺ T cells, with increasing of the CD8⁺ clones fraction by day 53. The amino acid sequences of CDR3 TCRb yellow fever specific clones formed a stable cluster by CD4⁺ T cells, further confirming the presence of novel immunogenic epitopes.

Hip range of motion (ROM) restriction is commonly observed in youth soccer players. This study aimed to investigate the effects of foam rolling training (FRT) and static stretching training (SST) on youth soccer players who have restricted hip ROM. The study included 34 youth soccer players with hip ROM restrictions, who were divided into two groups: FRT (n = 17, 15.9 ± 1.3 years) and SST (n = 17, 15.9 ± 1.7 years). Both groups were diagnosed with hip ROM restriction and enrolled in the study, then performed foam rolling and static stretching programs three times a week for six weeks. The Copenhagen Hip and Groin Outcome Score (HAGOS), and hip ROM, Lower Quarter Y-Balance Test (YBT-LQ), and isokinetic hip strength test were measured before and after intervention. The results showed that both FRT and SST were effective in improving hip function, as measured by HAGOS, and in increasing hip ROM, particularly flexion, abduction and internal rotation (p < 0.05). External rotation was significantly increased only in the SST group (p < 0.05). Both FRT and SST also improved YBT-LQ (p < 0.05). However, the SST group showed higher reach distances than the FRT group in all directions after training (p < 0.05). Both groups improved isokinetic hip strength in flexion and abduction movements, but when compared between groups, the FRT group showed greater improvement in peak torque (p < 0.05). In conclusion, FRT was more effective in reducing symptoms and pain and improving muscle strength, while SST improved hip mobility and dynamic balance more broadly. These results suggest that including both foam rolling and static stretching in a training program to optimize hip ROM and function in youth soccer players may be effective.

Within the framework of this paper, we proposed to analyze the evolution of demand for this destination during the restrictions generated by COVID 19, but also the interest of investors in this area. The Danube Delta represented the ideal destination of 2020, in a pandemic context, and continued to represent it in 2021. In this sense, the objectives of the research are represented by the analysis of the main indicators of sustainable tourism development, for which there are statistical data at the territorial level; they are recommended to be the most important for shaping the metamorphosed tourism paradigm. The purpose of the research carried out is to propose some measures/solutions to protect the ecosystem of the Danube Delta Biosphere, so that they can be implemented by the state institutions and even by the inhabitants of the local communities, in order to ensure the sustainability of the Danube Delta tourist destination in the future. The methodology for the analysis of the modeling the metamorphosed paradigm sustainable tourism post-COVID-19 in the Danube Delta was implemented through three successive stages: (1) the analysis of the main theoretical elements regarding sustainable tourism in the Danube Delta, (2) the evaluation of the main indicators proposed for shaping the metamorphosed paradigm of tourism and (3) calculating the average length of stay.

The natural and commonly used measure of accuracy for a confidence interval (CI) is its length, but it only applies to bounded CI's. More seriously, it is not an invariant measure, creating chaos on selecting CI's. Using the probability of false coverage as a finite and invariant measure of accuracy for a CI, we establish the uniformly most accurate (UMA) CI under weak restriction, which substantially improves the classical UMA unbiased CI for simplicity and optimality. [ABSTRACT FROM AUTHOR]

Objective: The authors report no conflicts of interest.To determine baseline sleep characteristics of male/female student-athletes across multiple sports using objective and subjective measures. Design: Prospective study. Setting: Division I college. Participants: Eighty-two male and female Division I student-athletes. Interventions: Participants completed 2 validated sleep questionnaires (Epworth Sleepiness Scale [ESS] and Single-Item Sleep Quality Scale [SISQS]) to assess subjective sleep. They also wore a validated sleep monitoring device (WHOOP 4.0 band) for at least 14 nights to collect objective data on total sleep time (TST) and sleep architecture. Main outcome measures: Overnight sleep variables, including TST, time spent awake in bed after falling asleep, time spent in light sleep, rapid eye movement (REM) sleep, and slow-wave sleep (SWS) cycles. Sleep quality and daytime sleepiness were also assessed. Results: There were no statistical differences between male and female student-athletes in average TST, sleep architecture, sleep consistency, SISQS, and ESS scores. The average TST was 409.2 ± 36.3 minutes. Sleep architecture consisted of 25.6% REM, 19.9% SWS, and 54.4% light sleep. The average sleep consistency was 61.6% ± 8.9%. The average SISQS score was 6.48 ± 1.71, and the average ESS score was 7.57 ± 3.82. A significant difference was found in average wake time between males and females (55.0 vs 43.7 min, P = 0.020), with an overall average of 50.2 ± 16.2 minutes. Conclusions: College student-athletes do not typically obtain the recommended amount of sleep. Optimizing sleep can positively affect academic and athletic performance. [ABSTRACT FROM AUTHOR]

Sleep restriction causes insulin resistance, but the mechanisms are not well understood. Exercise may be an effective mitigator. Short sleep duration is prevalent in modern society and may be contributing to type 2 diabetes prevalence. This review will explore the effects of sleep restriction on glycemic control, the mechanisms causing insulin resistance, and whether exercise can offset changes in glycemic control. Chronic sleep restriction may also contribute to a decrease in physical activity leading to further health complications. [ABSTRACT FROM AUTHOR]

The analysis of scientific sources provides grounds to assert that legal regulation is the regulation of social relations carried out through law and the entire set of legal means. The concept of «regulation» (from Latin regulo - rule) implies organization, adjustment, and bringing something into conformity with something else. In our view, to regulate means to define the behavior of individuals and their collectives, to direct their functioning and development, to provide certain limits, and to organize them purposefully. Alongside this, some scholars relate the term «regulation» solely to law as a system of norms and some other specific legal phenomena (legal relations, acts of law implementation). They disagree with the existing understanding of the regulation of social relations as the rigid and authoritative norming by the state and law, as, in their opinion, the category of «regulation» is not synonymous with coercion, rigid, and authoritative prescription. The legal norm establishes only a model of relations in which social interests must be correlated with the interests of society members, and alongside this, law widely uses such means of influencing people’s behavior as stimulation, encouragement, granting rights, etc. It is argued that to transition to the definition of legal regulation, it is necessary to refer to the theory of law, which provides explanations for the concepts of «legal influence» and «legal regulation». Legal influence is considered a broader concept, as it includes the normative-organizational influence on social relations not only through a system of special legal means (those that directly regulate these relations - legal norms, legal relations, acts of implementation and application of law), but also through other legal phenomena – legal consciousness, legal culture, legal principles, law-making process, etc. A proposed definition states that legal regulation is the authoritative influence on social relations carried out by the state through all legal means for the purpose of their organization, establishment, protection, and development. Besides such (regulatory) influence, law also exerts a spiritual-ideological influence on individual and social consciousness (both in the process of legal regulation and beyond). «Restrictions» and «prohibitions» as legal categories have been analyzed. The etymology of the words «restriction» and «prohibition,» their relationship to each other and to adjacent and synonymous concepts, have been explored, and an original interpretation of the content and essence of these concepts has been proposed. A number of features characterizing restrictions and prohibitions as legal categories have been identified (defined in normative legal acts; established to prevent potential abuses of law; associated with a «narrowing» of an individual’s legal status; presuppose a specific model of behavior, specifically restrictions entail active behavior, meaning to do only what is defined within limits; prohibitions entail passive behavior, meaning to refrain from doing prohibited actions; they perform a protective function in social relations; non-compliance with them is accompanied by a negative response from the state. The concept, characteristics, classification, and a systematic analysis of restrictions and prohibitions as means of legal regulation have been defined. Based on the analysis of dictionary, reference, encyclopedic literature, as well as specialized legal sources, the article formulates original definitions of «restriction». The specificity of these particular restrictions and prohibitions lies in their special area of application (they apply to individuals when exercising their powers within the civil service); they apply to specific subjects (directly to individuals who have the legal status of civil servants); their application is determined by a special purpose; they are characterized by specific, comprehensive normative legal regulation; their application is ensured by state coercion. Distinctive features inherent to restrictions and prohibitions in the field of legal regulation have been identified: individual character; preventive nature; limiting aspect; coercive nature; the presence of a special subject; connection to professional activity; relation to delict norms, and their essence has been explained. The normative basis for defining and applying restrictions and prohibitions as means of legal regulation has been characterized (substantive legislation, procedural legislation, sub-legislative normative legal acts). A classification of restrictions and prohibitions has been conducted, and it is proposed to conditionally divide them into three groups (personal, property, and mixed). [ABSTRACT FROM AUTHOR]

Copyright of Jiaoyu Kexue Wenxian is the property of Educational Science Literature (Chinese) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is a restrictive/hypoabsorptive procedure recommended for patients with obesity class 3. For safety reasons, SADI-S can be split into a two-step procedure by performing a sleeve gastrectomy (SG) first. This stepwise approach also provides an unprecedented opportunity to disentangle the weight loss mechanisms triggered by each component. The objective was to compare weight trajectories and post-prandial endocrine and metabolic responses of patients with obesity class 3 submitted to SADI-S or SG as the first step of SADI-S. Methods: Subjects submitted to SADI-S (n = 7) or SG (n = 7) at a tertiary referral public academic hospital underwent anthropometric evaluation and a liquid mixed meal tolerance test (MMTT) pre-operatively and at 3, 6, and 12 months post-operatively. Results: Anthropometric parameters, as well as metabolic and micronutrient profiles, were not significantly different between groups, neither before nor after surgery. There were no significant differences in fasting or post-prandial glucose, insulin, C-peptide, ghrelin, insulin secretion rate, and insulin clearance during the MMTT between subjects submitted to SADI-S and SG. There was no lost to follow-up. Conclusions: The restrictive component seems to be the main driver for weight loss and metabolic adaptations observed during the first 12 months after SADI-S, given that the weight trajectories and metabolic profiles do not differ from SG. These data provide support for surgeons' choice of a two-step SADI-S without jeopardizing the weight loss outcomes. [ABSTRACT FROM AUTHOR]

This research examines whether and how feelings of physical constraints can increase consumers' preference for mind-expanding products, such as products that broaden perspectives and viewpoints. Three studies show that feelings of physical constraints (such as when consumers commute and buckle their seatbelts, which restricts their movement) motivate them to increase mental space and break free from mental limitations as an alternative way to compensate for the physical restrictions they experience. As a result, consumers prefer mind-expanding products more because the content of these products helps them expand their mental space. Together, the current research integrates and extends theories of fluid compensatory consumption and offers actionable managerial implications for marketers. [ABSTRACT FROM AUTHOR]

Copyright of ASBU Law Journal is the property of Social Sciences University of Ankara and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

All countries in the world are currently witnessing a dramatic increase of organized criminality, the consolidation of national criminal structures and, what is worse, their international merger for criminal syndicates. In such circumstances, the use of state institutions to deal with the increasing force and spreading of crime in the world becomes inevitable. Under these conditions, the respect for the human being, the respect for his or her dignity and value, freedom of thought and action, and other fundamental rights and freedoms - all these are the general premise for the achievement of the goals of a contemporary world society and the foundation of the universal progressive development of any state, because the free person, as the axiom of development, can offer something more to society than the suppressed one. The last argument is what makes the idea of the freedom of the individual and the primacy of human rights relevant, including in the context of evidence proceedings in criminal trials. Each time when criminal proceedings are authorized, the limits on the rights of both the subjects of the proceedings and other persons will be considered and decided. In this context, the principle of proportionality is of major and undeniable relevance. [ABSTRACT FROM AUTHOR]

ABSTRACT In humans, sterile alpha motif (SAM) domain- and histidine–aspartic acid (HD) domain-containing protein 1 (SAMHD1) is a dNTPase enzyme that prevents HIV-1 infection in non-cycling cells, such as differentiated THP-1 cells and human primary macrophages. Although phosphorylation of threonine 592 (T592) in SAMHD1 is recognized as the primary regulator of the ability to prevent HIV-1 infection, the contributions of SAMHD1 acetylation to this ability remain unknown. Mass spectrometry analysis of SAMHD1 proteins derived from cycling and non-cycling THP-1 cells, primary cycling B cells, and primary macrophages revealed that SAMHD1 is preferentially acetylated at lysine residues 354, 494, and 580 (K354, K494, and K580). In non-cycling cells, SAMHD1 is preferentially acetylated at K580, suggesting that this post-translational modification may contribute to the ability of SAMHD1 to block HIV-1 infection. Consistent with this finding, we found that mutations in K580 disrupted the ability of SAMHD1 to block HIV-1 infection without affecting the ability of SAMHD1 to deplete cellular dNTP levels. Gene editing of SAMHD1 in macrophage-like cells revealed that an intact K580 is required for HIV-1 restriction. This finding suggests that K580 acetylation in SAMHD1 is essential for blocking HIV-1 infection. More importantly, we found that a larger proportion of SAMHD1 featuring K580 acetylation could be detected in human primary macrophages when compared to human primary monocytes. In agreement, we found that SAMHD1 is acetylated during the monocyte-to-macrophage differentiation process. This finding agrees with the idea that the blockade of HIV-1 infection in macrophages requires SAMHD1 acetylation.IMPORTANCEThe natural inhibitor of HIV-1, sterile alpha motif (SAM) domain- and histidine–aspartic acid (HD) domain-containing protein 1 (SAMHD1), plays a pivotal role in preventing HIV-1 infection of macrophages and dendritic cells, which are vital components of the immune system. This study unveils that SAMHD1 undergoes post-translational modifications, specifically acetylation at lysines 354, 494, and 580. Our research underscores the significance of these modifications, demonstrating that acetylation at residue K580 is indispensable for SAMHD1's efficacy in blocking HIV-1 infection. Notably, K580 is found in a critical regulatory domain of SAMHD1, highlighting acetylation as a novel layer of SAMHD1 regulation for HIV-1 restriction in humans. A comprehensive understanding of the regulation mechanisms governing this anti-HIV-1 protein is crucial for leveraging nature's defense mechanisms against HIV-1 and could pave the way for innovative therapeutic strategies.

Au terme de la présente étude, nous sommes parvenu à la conclusion dont voici la teneur. La destruction des ressources naturelles, la baisse de taux de scolarité et d’activités commerciales sont là les éléments constitutifs à la base du départ massif de ces sociétés. Toutefois, le manque d’emploi et la prolifération des maladies d’origine hydrique sont aussi signalés.

Background: Executive functions, notably inhibition, significantly influence decision-making and behavioral regulation in team sports. However, more research must be conducted on individual player characteristics such as experience and motor skills. This study assessed how accumulated practical experience moderates inhibition in response to varying task difficulty levels. Methods: Forty-four university students (age: 20.36 ± 3.13 years) participated in this study with two sessions: one followed standard 1 × 1 basketball rules ("Regular Practice"), while the other imposed motor, temporal, and spatial restrictions ("Restriction Practice"). Functional difficulty was controlled by grouping pairs with similar skill levels. Flanker and Go-Nogo tasks were used. Results: Increasing complexity worsened cognitive performance (inhibition). "Restriction Practice" showed a significantly slower and less accurate performance in both tests than "Regular Practice" (p < 0.001). Experience positively impacted test speed and accuracy (p < 0.001). Conclusion: In sports, acute cognitive impacts are intrinsically linked to the task's complexity and the athlete's cognitive resources. In this sense, it is essential to adjust individually the cognitive demands of the tasks, considering each athlete's specific cognitive abilities and capacities. [ABSTRACT FROM AUTHOR]

The purpose of this study was to discover the association between disability in everyday life and social activities due to chronic diseases and suicidal ideation (SI), suicidal plan (SP), and suicidal attempt (SA) from the Korea National Health and Nutrition Examination Survey (KNHANES), considering the cross-sectional design of this study, 2016–2018 dataset. Variables for finding the associated factors of SI, SP, and SA were confirmed through random forest (RF), decision tree, generalized linear model (GLM), and support vector machine (SVM), and the performance of each model is listed. A total of 17,323 (males: 7,530, females: 9793) responders from the KNHANES from 2016 to 2018 were employed for the study. The relationship between restrictions on daily life, social activities, and three stages of suicidal behaviors due to diseases were analyzed using the R function (R version 4.2.0), randomForest, ctree, glm, and ksvm. The F1-score is a measure used to evaluate the accuracy of the performance of a model, in the binary classification. The score of 1 indicates good performance, whereas a score of 0 signifies poor performance. Due to chronic diseases, disability in everyday life and social activities lead to suicide behaviors. In our study, we examined the impact of limitations in daily living and social activities on suicidal behaviors among participants. Our findings revealed that for those experiencing such limitations, the odds ratios (ORs) for SIs were 6.10 (95% CI: 3.99–9.34) for males and 2.61 (1.79–3.81) for females. SPs were 3.69 (2.36–5.78) for males and 3.94 (2.70–5.75) for females. Similarly, the odds ratios for SAs were 5.04 (2.51–10.13) for males and 2.71 (1.48–4.98) for females, indicating a significant association between these limitations and increased suicidal behaviors, with variances observed between genders. These results underscore the necessity of addressing daily living and social activity restrictions when considering mental health interventions and suicide prevention strategies. In RF, GLM, and SVM, F1-score were 0.8192, 0.6887, and 0.9687 in SA, respectively. Among the patients with chronic disease, those with sequelae, low incomes, and low levels of education had limitations in daily activities and social activities, which increased the likelihood of suicidal thoughts, planning, and attempts. • The associated factors of SI, SP, and SA were revealed in 17,323 participants. • Four methods were used to identify the factors associated with suicide: RF, DT, GLM, and SVM. • Total income was the most important variable for suicidal behavior. • SA had higher performances than SI and SP. [ABSTRACT FROM AUTHOR]

This paper considers comparison problems for dispersion matrices of predictors under two competing linear models with having the same restrictions on their joint unknown parameters. One of the competing model is a constrained linear model (CLM) and the other one is a constrained over-parameterized model (COLM), obtained by adding new regressors to the CLM. After converting explicitly CLM and its COLM to their implicitly constrained forms, analytical expressions and properties of the best linear unbiased predictors (BLUPs) are given via using some quadratic matrix optimization methods under the models. In particular, the authors provide some equalities and inequalities for dispersion matrices of BLUPs under the models by using some formulas of ranks and inertias of block matrices. Comparison results on the dispersion matrices are also derived for special cases. [ABSTRACT FROM AUTHOR]

Copyright of Critique of Law: Independent Legal Studies / Krytyka Prawa: Niezalezne Studia nad Prawem is the property of Akademia Leona Kozminskiego and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The outbreak of the COVID‐19 poses a great threat to students globally. China has taken steps to keep students from becoming infected for more than 30 months, while other countries have also taken steps. Comparing the intentions, implementation, immediate and long‐term effects of these initiatives can shed more light on the care of adolescents in schools. Objective: The focus of the study is to describe the full range of school prevention measures in China, identifying when they work and when they do not. At the same time, some typical measures taken in other countries' schools are presented and compared to provide a comprehensive discussion. Methods: This study attempted to combine data comparison, information analysis, policy interpretation, and participatory observation to form a comprehensive analytical network. Results: China's schools have gone through of lucky periods, safety periods, difficult periods, and crisis periods. These efforts are due to the government's intense control measures, strict accountability of school administrators, frequent nucleic acid testing, widespread vaccination, and widely implemented online learning. In comparison, the measures taken by China are difficult to implement, and the price paid by the government, schools and students needs to be further assessed and reflected upon. Conclusions: The virus is able to destroy the school's defence with ease. There should be a consensus among countries for a permanent virus control strategy, but the severity of the various measures needs to be appropriately determined, strict control measures can also have negative effects. [ABSTRACT FROM AUTHOR]

Purpose: To analyze the utility and outcomes of available endourologic options to treat ureteral stricture after kidney transplantation (KT). Methods: A systematic review was carried out for all English language articles from 2000 to 2023 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) standards using EMBASE, MEDLINE, SCOPUS, Google scholar, and Cochrane library. The search term combination for the string was follows: [(Ureteral stricture) OR (ureter stenosis) OR (ureteral stenosis) OR (Stricture ureter) OR (Narrowing ureter) OR (Ureter restriction) OR (ureteral restriction) OR (ureteral narrowing) OR (ureteral obstruction) OR (ureter obstruction) OR (obstructing ureter) OR (obstructive ureter) OR (narrow ureter) OR (ureteral narrow)] AND [(kidney transplant) OR (transplanted kidney) OR (transplant) OR (transplantation)] AND [(management) OR (Robotic) OR (laser) OR (stent) OR (dilatation) OR (dilation) OR (endoscopic) OR (endourological) OR (Urologic) OR (laparoscopic) OR (surgery) OR (treatment)]. Case reports, review articles, animal and laboratory studies were excluded. Risk of bias assessment was conducted using the RoB 2 and ROBINS-I tools. Results: A total of 1102 relevant articles published from 2000 to 2023 were found. After screening of titles and abstracts, a total of 19 articles were included in our systematic review. Ureteral stent/nephrostomy placement, balloon dilatation (ureteroplasty) with or without laser was used as initial approaches whereas follow-up and success rate were analyzed among other parameters. Conclusions: The management of ureteral strictures after KT is challenging and selecting the most appropriate treatment is crucial for successful outcomes. Our review suggests that, an endourologic management is a safe option with good long-term outcomes, especially in short and early strictures. [ABSTRACT FROM AUTHOR]

BackgroundInjuries are among the leading causes for hospitalizations and emergency department (ED) visits. COVID-19 restrictions ensured safety to Canadians, but also negatively impacted health outcomes, including increasing rates of certain injuries. These differences in trends have been reported internationally however the evidence is scattered and needs to be better understood to identify opportunities for public education and to prepare for future outbreaks.ObjectiveA scoping review was conducted to synthesize evidence regarding the impact of COVID-19 restrictions on unintentional injuries in Canada, compared to other countries.MethodsStudies investigating unintentional injuries among all ages during COVID-19 from any country, published in English between December 2019 and July 2021, were included. Intentional injuries and/or previous pandemics were excluded. Four databases were searched (MEDLINE, Embase, Web of Science, SPORTDiscus), and a gray literature search was also conducted.ResultsThe search yielded 3,041 results, and 189 articles were selected for extraction. A total of 41 reports were included from the gray literature search. Final studies included research from: Europe (n = 85); North America (n = 44); Asia (n = 32); Oceania (n = 12); Africa (n = 8); South America (n = 4); and multi-country (n = 4). Most studies reported higher occurrence of injuries/trauma among males, and the average age across studies was 46 years. The following mechanisms of injury were reported on most frequently: motor vehicle collisions (MVCs; n = 134), falls (n = 104), sports/recreation (n = 65), non-motorized vehicle (n = 31), and occupational (n = 24). Injuries occurring at home (e.g., gardening, home improvement projects) increased, and injuries occurring at schools, workplaces, and public spaces decreased. Overall, decreases were observed in occupational injuries and those resulting from sport/recreation, pedestrian-related, and crush/trap incidents. Decreases were also seen in MVCs and burns, however the severity of injury from these causes increased during the pandemic period. Increases were observed in poisonings, non-motorized vehicle collisions, lacerations, drownings, trampoline injuries; and, foreign body ingestions.ImplicationsFindings from this review can inform interventions and policies to identify gaps in public education, promote safety within the home, and decrease the negative impact of future stay-at-home measures on unintentional injury among Canadians and populations worldwide.

Introduction: Total hip arthroplasty (THA) is an operation that is successfully performed in patients with end-stage hip osteoarthritis. In this study, we aimed to evaluate the compliance level of primary THA patients with their doctor’s post-operative advice on restricted hip movements and environment modifications to prevent dislocation. Methods: A survey consisting of 14 questions was prepared, questioning 320 patients who underwent THA in our clinic between 2015 and 2021. One hundred and forty three patients agreed to participate in our study, and their answers regarding whether they followed the introductions recommended by the surgeon who performed the surgery were recorded. Results: 99% of the 143 patients who participated in the survey stated that they were given some advice. 46% (n=66) of the patients stated that they were told that these introductions should be applied for life. 60% of the patients did not cross their legs, 74% did not squat, 86% did not sit cross-legged, 76% did not use toilet risers, and 89% do not do unrecommended sports. Conclusion: Most patients complied with the surgeon’s recommendations in the early period; however, we observed that compliance decreased over time.

The increasing integration of ChatGPT, a Generative Artificial Intelligence (Gen-AI) model, into educational environments has sparked substantial ethical concerns. This paper addresses the crucial question of whether to impose restrictions or legislate the usage of Gen-AI, with ChatGPT as a pivotal case study. Through systematic literature review and frequency of occurrence analysis, 10 ethical concerns were selected for further analysis using the Analytic Hierarchy Process (AHP). The analysis responses of 10 expert panels show that the top concerns, as revealed by their weights, after meeting the consistency requirement, include copyright, legal, and compliance issues (0.1731), privacy and confidentiality (0.1286), academic integrity (0.1206), incorrect reference and citation practices (0.1111), and safety and security concerns (0.1050). Evaluating the impact of these concerns on the policy alternatives (restriction and legislation), the findings revealed that “Restriction” received a higher weight (0.513712) compared to “Legislation” (0.485887). Notably, copyright, legal, and compliance issues, privacy and confidentiality, and academic integrity emerged as crucial factors influencing the decision between restriction and legislation. This study offers valuable insights for educational institutions and policymakers, suggesting the need for inclusive discussions, pilot programs to assess impacts on critical thinking, development of clear guidelines, flexible regulatory frameworks, awareness campaigns, and potential strategies for ethical and responsible use.

Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to prevent fusion between the viral envelope and cell membrane, numerous studies have underscored the importance of viral envelope proteins in determining the susceptibility of viruses to IFITMs. Mutations in envelope proteins may lead to viral escape from direct interaction with IFITM proteins or result in indirect resistance by modifying the viral entry pathway, allowing the virus to modulate its exposure to IFITMs. In a broader context, the nature of viral envelope proteins and their interaction with IFITMs can play a crucial role in the context of adaptive immunity, leading to viral envelope proteins that are more susceptible to antibody neutralization. The precise mechanisms underlying these observations remain unclear, and further studies in this field could contribute to a better understanding of how IFITMs control viral infections. [ABSTRACT FROM AUTHOR]

Heavenly teachings can be divided into three categories: beliefs, moralities and jurisprudence. Therefore, moral instructions are among the most important Quranic teachings that include a wide range of moral virtues and vices. In order to understand moral concepts, to identify their importance, to determine the position of each concept through which it is possible to take the right educational steps to train the people of the society, there is a need for indicators and standards that cannot be achieved easily, but one must try different ways to obtain them because they are not clearly explained in religious texts. With a descriptive and analytical approach and by making studies in the Arabic language, this article has determined these indicators for the classification of moral concepts: repetition, restriction, superlative, analogy, comparison of phrases and themes. With examples from the verses of the Quran, we have tried to explain that, based on these examples, the moral virtues of sincerity and gratitude are considered among the highest moral virtues, respectively. Though, for the final conclusion, a complete investigation must be done on the moral verses, which is being done in a detailed research. [ABSTRACT FROM AUTHOR]

Introduction: Total hip arthroplasty (THA) is an operation that is successfully performed in patients with end-stage hip osteoarthritis. In this study, we aimed to evaluate the compliance level of primary THA patients with their doctor's post-operative advice on restricted hip movements and environment modifications to prevent dislocation. Methods: A survey consisting of 14 questions was prepared, questioning 320 patients who underwent THA in our clinic between 2015 and 2021. One hundred and forty three patients agreed to participate in our study, and their answers regarding whether they followed the introductions recommended by the surgeon who performed the surgery were recorded. Results: 99% of the 143 patients who participated in the survey stated that they were given some advice. 46% (n=66) of the patients stated that they were told that these introductions should be applied for life. 60% of the patients did not cross their legs, 74% did not squat, 86% did not sit cross-legged, 76% did not use toilet risers, and 89% do not do unrecommended sports. Conclusion: Most patients complied with the surgeon's recommendations in the early period; however, we observed that compliance decreased over time. [ABSTRACT FROM AUTHOR]

Copyright of European Surgery: ACA Acta Chirurgica Austriaca is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We examine the extent to which financial sanctions imposed by Germany through its European Union and United Nations commitments cause collateral damage on Germany's trade in goods and services. Financial sanctions reduce Germany's inflows and outflows of financial assets, as well as imports and exports of goods and services. The relative effects on trade in goods and services are weaker than on financial assets, about half as large in the case of goods and two‐thirds as large in the case of services. The effect on trade in goods is entirely due to episodes where financial sanctions are accompanied by export restrictions of specific goods. In the case of services trade, only exports are affected by financial sanctions once export restrictions are considered. The primary channel through which sanctions affect the three types of cross‐border flows is the extensive margin. Anticipation effects are quite strong for financial assets and weak for services and goods. [ABSTRACT FROM AUTHOR]

Influenza virus has been one of the most prevalent and researched viruses globally. Consequently, there is ample information available about influenza virus lifecycle and pathogenesis. However, there is plenty yet to be known about the determinants of influenza virus pathogenesis and disease severity. Influenza virus exploits host factors to promote each step of its lifecycle. In turn, the host deploys antiviral or restriction factors that inhibit or restrict the influenza virus lifecycle at each of those steps. Two broad categories of host restriction factors can exist in virus-infected cells: (1) encoded by the interferon-stimulated genes (ISGs) and (2) encoded by the constitutively expressed genes that are not stimulated by interferons (non-ISGs). There are hundreds of ISGs known, and many, e.g., Mx, IFITMs, and TRIMs, have been characterized to restrict influenza virus infection at different stages of its lifecycle by (1) blocking viral entry or progeny release, (2) sequestering or degrading viral components and interfering with viral synthesis and assembly, or (3) bolstering host innate defenses. Also, many non-ISGs, e.g., cyclophilins, ncRNAs, and HDACs, have been identified and characterized to restrict influenza virus infection at different lifecycle stages by similar mechanisms. This review provides an overview of those ISGs and non-ISGs and how the influenza virus escapes the restriction imposed by them and aims to improve our understanding of the host restriction mechanisms of the influenza virus. [ABSTRACT FROM AUTHOR]

Peculiarities of the genetic structure of the population of Holstein cattle bred in Ukraine were studied by beta-casein and tumor necrosis factor alpha loci. Using the methods of allele-specific PCR (AS-PCR) and PCR with restriction fragment length polymorphism (PCR-RFLP) analysis, polymorphism of the beta-casein gene (CSN2) by allelic variants A1 and A2 and of the tumor necrosis factor-alpha (TNF-α) by SacI-polymorphism in the promoter region of the gene (–824 A>G marker mutation) and RsaI-polymorphism in the fourth exon were analyzed. It was proven that both loci are polymorphic in the studied cattle population. For each of the polymorphic loci, the main genetic and population parameters of the Holstein cow population were established. For the CSN2 locus, a significant predominance of the frequency of the A2 allele over A1 was established (0.78 vs. 0.22). For the SacI- and RsaI-polymorphisms of TNF-α, maximal (1.980 and 1.988) values of the locus polymorphism level (the number of effective alleles) were detected. For both mutations in the TNF-α gene, actual parity in the frequency values of the corresponding alleles was established (0.55 and 0.45 for the SacI-polymorphism; 0.54 and 0.46 for the RsaI-polymorphism). For the RsaI-polymorphism in the TNF-α fourth exon, a deviation from the state of genetic equilibrium according to Hardy–Weinberg was recorded in the studied population of animals, and a significant excess of heterozygous individuals was detected (25%). Based on the results of the analysis of milk productivity parameters of individuals with different CSN2 locus genotypes, it was established that individuals with the A2A2 genotype are characterized by higher values of standard milk production as compared with individuals with the A1A1 genotype (p = 0.042). For the SacI- and RsaI-polymorphism of the TNF-α gene, there were no significant differences in the parameters of standard milk productivity for two lactations between individuals with different genotypes. [ABSTRACT FROM AUTHOR]

Pregnant women with absolute contraindications may be advised against physical activity throughout pregnancy. In this context, bed rest elevates the short-term risk of neonatal complications, thereby exacerbating negative long-term effects on childhood development. The aim of the current study was to investigate the impact of various physical activity interventions during bed rest or activity restriction in pregnancy on factors such as birth weight, preterm birth, maternal hypertension, gestational age at delivery, and the incidence of cesarean sections. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review was designed. The protocol was registered in the International Prospective Registry of Systematic Reviews (PROSPERO) (CRD42022370875). Nine studies, with a total sample of 3173 women, from six countries on four continents were included. There were significant differences in the relationship between bed rest status and birth weight (Z = 2.64; p = 0.008) (MD = 142.57, 95% CI = 36.56, 248.58, I2 = 0%, Pheterogeneity = 0.45) favourable to active groups. No significant differences were found in other analyzed outcomes. Pregnant women who experience this problem must maintain a minimum of daily activity to alleviate these physiological complications and the medical field must understand the consequences of physical inactivity during pregnancy. [ABSTRACT FROM AUTHOR]

Tensors are often studied by introducing preorders such as restriction and degeneration. The former describes transformations of the tensors by local linear maps on its tensor factors; the latter describes transformations where the local linear maps may vary along a curve, and the resulting tensor is expressed as a limit along this curve. In this work, we introduce and study partial degeneration, a special version of degeneration where one of the local linear maps is constant while the others vary along a curve. Motivated by algebraic complexity, quantum entanglement, and tensor networks, we present constructions based on matrix multiplication tensors and find examples by making a connection to the theory of prehomogeneous tensor spaces. We highlight the subtleties of this new notion by showing obstruction and classification results for the unit tensor. To this end, we study the notion of aided rank, a natural generalization of tensor rank. The existence of partial degenerations gives strong upper bounds on the aided rank of a tensor, which allows one to turn degenerations into restrictions. In particular, we present several examples, based on the W-tensor and the Coppersmith--Winograd tensors, where lower bounds on aided rank provide obstructions to the existence of certain partial degenerations. [ABSTRACT FROM AUTHOR]

On the basis that the literature shows that most of the serial murders are committed by men and with sexual motivation, the research is a preliminary approach which aims to approach the cultural influence on the sexual motivation of serial killers. Eighty-six cases of serial murders with male perpetrators from different countries have been analyzed, committed between 1900 and 2020. The variables evaluated are related to the serial offender, victimology, modus operandi, sexual motivation typology and the actions related to such classification. In indulgence countries, pre mortem sexual acts (44.20%), interference with the victim's body (36.0%) and mutilation (27.90%) are the most common; the same occurs in restrictive countries, although in a lower percentage, with mutilation 7.0% being the only statistically significant variable (X² = 0.034). Direct-sadistic motivation is the most present, being 52.30% in indulgence countries and 18.60% in restrictive countries, there being a significant relationship (X² = 0.026). There is a partial influence of culture on modus operandi and sexual motivation according to the higher or lesser presence of social norms and how they influence the individual's decision making. [ABSTRACT FROM AUTHOR]

This mixed methods study assessed the perceptions of food choices among SNAP participants and SNAP-eligible non-participants when exposed to two alternative SNAP policy options: restrictions on sugar-sweetened beverages (SSBs) and incentives for fruit and vegetable (FV) purchases. Twelve focus groups that included a randomized food choice experiment were conducted in seven counties in Georgia, involving 73 participants. Participants had a favorable view toward incentivizing FV; responses toward SSB restrictions were mixed. FV incentives were associated with greater spending on FV and lower spending on SSBs, and SSB restriction was associated with lower spending on SSBs. [ABSTRACT FROM AUTHOR]

The nonlinearity of vectorial functions and of their restrictions to manifolds are defined as the Hamming distance to the set of affine mappings and of their restrictions to the manifold, respectively. Relations between the parameters of the nonlinearity of a vectorial function and their analogues for its coordinate functions and its restrictions to manifolds are established. An analogue of the Parseval identity for such parameters of vectorial functions is proved, which implies the upper bound (qk − 1)qn−k − qn/2−k for the nonlinearity of a mapping over a q-element field of n variables with k coordinates. Attainability conditions for this estimate are found, and a class of Boolean vectorial functions with high value of nonlinearity is constructed. Estimates characterizing the distribution of the nonlinearity of a vectorial function and of its restrictions to manifolds are obtained. [ABSTRACT FROM AUTHOR]

Copyright of Studii de Ştiintă şi Cultură is the property of Studii de Stiinta si Cultura and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Policies related to large-scale restrictions during the pandemic require each individual to carry out physical activities and routines at home, so every activity that is usually carried out is now completely limited, and it affects the current public health, as well as there is no research related to the relationship between physical activity and BMI in the 2018 batch of the Faculty of Medicine, Christian University of Indonesia. It is the basis of researchers conducting this research. Method: This research design is descriptive-analytic, with a cross-sectional approach, with a population of 156 respondents and a sample of 113 respondents whom Spearman will analyze with a p-value < 0.05. Result: The frequency of physical activity in the 2018 Indonesian Christian University Faculty of Medicine students in the "Light" category was 54% (61 people), "Medium" was 30.1% (34 people), and "Heavy" was 15.9% (18 people). Meanwhile, the frequency of Body Mass Index in the respondents in this study was divided into the categories of "undernourished" by 11.5% (13 people), "Normal" by 63.7% (72 people), "Overweight" by 9.7% (11 people), and "Obesity" by 15% (17 people). Then, both were correlated with a significant value of 0.04. Conclusion: The Body Mass Index in the 2018 Indonesian Christian University Faculty of Medicine students was in the normal category at most 63.7% (72 people), while the most physical activity was, the light category was 54% (61 people), and these two variables had a correlation one another. [ABSTRACT FROM AUTHOR]

Copyright of Umm Al-Qura University Journal for Languages & Literature is the property of Association of Arab Universities and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Young Intellectuals / Genç Mütefekkirler Dergisi is the property of Journal of Young Intellectuals and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BackgroundExecutive functions, notably inhibition, significantly influence decision-making and behavioral regulation in team sports. However, more research must be conducted on individual player characteristics such as experience and motor skills. This study assessed how accumulated practical experience moderates inhibition in response to varying task difficulty levels.MethodsForty-four university students (age: 20.36 ± 3.13 years) participated in this study with two sessions: one followed standard 1 × 1 basketball rules (“Regular Practice”), while the other imposed motor, temporal, and spatial restrictions (“Restriction Practice”). Functional difficulty was controlled by grouping pairs with similar skill levels. Flanker and Go-Nogo tasks were used.ResultsIncreasing complexity worsened cognitive performance (inhibition). “Restriction Practice” showed a significantly slower and less accurate performance in both tests than “Regular Practice” (p

Determiner spreading, the phenomenon whereby adnominal modifiers carry an ‘additional’ determiner, has been studied extensively for a variety of languages, most notably Greek, Semitic, and Scandinavian languages. Interestingly, the same phenomenon occurs in the Bantu language Rukiga. We show how the Rukiga augment is parallel to the Greek determiner in the context of modification, and how it triggers a restrictive reading when present on a larger class of modifiers than familiar so far: relative clauses, adjectives, possessives, and certain quantifiers. Considering its morphosyntactic and interpretational properties, we propose that the variation in the presence versus absence of the augment on modifiers is due to different underlying structures, applying an analysis of determiner spreading in terms of a reduced relative clause structure.

When developing safety regulations for chemicals, the international society is constantly searching for safer analogues of highly hazardous chemicals to use as alternatives in various products. Within the Scientific Research Work under the State Program ‘Provision of Chemical and Biological Safety in 2021–2024’, The Russian Register of Potentially Hazardous Chemical and Biological Substances of the Federal Scientific Center of Hygiene named after F.F. Erisman of Rospotrebnadzor has developed a concept on replacement of highly hazardous chemicals in various products (food products, synthetic detergents and household chemicals, pesticides, paints and varnishes, basic chemicals) with their safer analogues. Still, we should highlight that regulation of highly hazardous chemicals in articles has not been developed sufficiently in the RF. Therefore, the purpose of the study was to provide scientific substantiation for criteria and rules for assigning chemicals in articles as prohibited and (or) restricted. Materials this study is based on are represented by the regulatory legal acts of the Russian Federation, EEC and the EU (in particular, Decrees, Resolutions, Technical Regulations, Directives, Regulations, etc. in the field of safe management of substances of concern), as well as domestic and international databases, scientific articles and monographs containing information on the toxic properties of chemicals. In order to develop effective measures to minimize the risk of exposure to chemicals in articles and their safe management at all stages of a life cycle, the study provides substantiation of criteria and rules for assigning chemicals in articles as prohibited and (or) restricted and proposes a mechanism for the creation of a National list of chemicals of concern in articles. When created, this List will allow monitoring of their circulation on the territory of the Russian Federation, proper waste disposal, and stimulating research work to find alternatives.