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Your search keyword '"RESTIFO PECORELLA, G"' showing total 41 results
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41 results on '"RESTIFO PECORELLA, G"'

3. 99mTc-MIBI SPECT in the differential diagnosis of brain metastases

Author

Minutoli, Fabio, Angileri, Filippo, Baldari, Sa, Restifo Pecorella, G, Campenni', Alfredo, Vadala', Antonino, Restuccia, A, Conti, Alfredo, Baldari, Sergio, MINUTOLI, Fabio, ANGILERI, Filippo, Baldari Sa, Restifo Pecorella G, CAMPENNI', Alfredo, VADALA', Antonino, Restuccia A, CONTI, Alfredo, and BALDARI, Sergio

Subjects
na
Published
2006

39. [186Re]HEDP in the palliation of painful bone metastases from cancers other than prostate and breast.

Author

Minutoli F, Herberg A, Spadaro P, Restifo Pecorella G, Baldari S, Aricò D, Altavilla G, and Baldari S

Subjects
Adult, Aged, Aged, 80 and over, Bone Neoplasms complications, Breast Neoplasms radiotherapy, Breast Neoplasms secondary, Female, Humans, Male, Middle Aged, Pain etiology, Pain Measurement radiation effects, Prostatic Neoplasms radiotherapy, Prostatic Neoplasms secondary, Radiopharmaceuticals therapeutic use, Radium therapeutic use, Treatment Outcome, Bone Neoplasms radiotherapy, Bone Neoplasms secondary, Etidronic Acid analogs & derivatives, Etidronic Acid therapeutic use, Pain prevention & control, Palliative Care methods
Abstract

Aim: Palliative therapy using [186Re]hydroxyethylidene diphosphonate (HEDP) has been widely tested in patients with bone metastases from prostate and breast cancers. Whereas, to the best of our knowledge, only few cases of bone metastases from tumors other than prostate and breast treated with [186Re]HEDP have been reported. The aim of this paper is to report our experience with 186Re-HEDP in the palliation of painful bone metastases from tumors other than prostate and breast., Methods: In this study 41 patients (17 non-small cell lung cancer-NSCLC, 1 small cell lung cancer, 1 lung neuroendocrine tumor, 8 bladder cancer, 3 kidney cancer, 3 gastric cancer, 1 uterine carcinoma, 1 colon cancer, 1 rhinopharynx carcinoma, 1 medullary thyroid carcinoma, 1 ovarian cancer, 1 esophagus cancer, 2 carcinoma of unknown origin) are evaluated. All patients had lesions with increased [99mTc]MDP uptake and none had radiological findings of mainly osteolytic lesions. A total of 46 therapeutic cycles were performed using a [186Re]HEDP activity of 1 295 MBq for each administration. After treatment, patients were followed up for 3 months or to the time of pain recurrence (if longer than 3 months). Responses were evaluated using a validated method considering the modifications of pain index, analgesic intake and performance status., Results: Treatment efficacy was complete in 49% (20/41) of patients, partial in 36% (15/41) and negative in 15% (6/41). Namely, we observed 35% (6/17) complete, 41% (7/17) partial and 24% (4/17) negative responses in patients with NSCLC and 63% (5/8) complete, 25% (2/8) partial and 12% (1/8) negative responses in patients affected by bladder cancer. The median duration of pain relief in responder patients was 10 weeks. A mild platelet toxicity occurred in 32% (13/41) of patients., Conclusions: Pain palliation with [186Re]HEDP seems highly effective and safe also in patients with bone metastases from cancers other than prostate and breast. Patients who can benefit from the treatment with [186Re]HEDP can be selected on the basis of [99mTc]MDP bone scan and radiological examination findings.

Published
2006

40. Investigation of brain tumours with (99m)Tc-MIBI SPET.

Author

Baldari S, Restifo Pecorella G, Cosentino S, and Minutoli F

Subjects
Brain Neoplasms metabolism, Humans, Radionuclide Imaging, Radiopharmaceuticals pharmacokinetics, Brain Neoplasms diagnostic imaging, Brain Neoplasms therapy, Technetium Tc 99m Sestamibi pharmacokinetics
Abstract

The aim of this paper is to give the reader an updated overview of (99m)Tc-MIBI SPET applications in investigating brain tumours. Elements determining MIBI uptake at the level of the brain are first mentioned. (99m)Tc-MIBI SPET features in different malignant and benign brain lesions (low and high grade gliomas, glioblastoma multiforme, metastasis, lymphoma, meningioma, neuroma, radiation necrosis and other rarer brain lesions) are reviewed. The ability of 99mTc-MIBI SPET, alone or in combination with other radiotracers, in the differential diagnosis of brain lesions is discussed. We outline (99m)Tc-MIBI SPET value in determining brain tumours grading and in distinguishing tumour recurrence from radiation necrosis. Clinical applications of 99mTc-MIBI in the management of AIDS patients, where discrimination between lymphoma and several different lesions only on the basis of CT or MRI findings is often impossible, are reported. In addition the relationships among (99m)Tc-MIBI SPET, P-glycoprotein (MDR-1 gene product) expression in brain neoplasms and chemotherapy response are mentioned.

Published
2002

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