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Objective: Restless legs syndrome (RLS) is a neurological condition that causes uncomfortable sensations in the legs and an irresistible urge to move them, typically during periods of rest. The genetic basis and pathophysiology of RLS are incompletely understood. We sought to identify additional novel genetic risk factors associated with RLS susceptibility. Methods: We performed a whole‐genome sequencing and genome‐wide association meta‐analysis of RLS cases (n = 9,851) and controls (n = 38,957) in 3 population‐based biobanks (All of Us, Canadian Longitudinal Study on Aging, and CARTaGENE). Results: Genome‐wide association analysis identified 9 independent risk loci, of which 8 had been previously reported, and 1 was a novel risk locus (LMX1B, rs35196838, OR 1.14, 95% CI 1.09–1.19, p value = 2.2 × 10−9). Furthermore, a transcriptome‐wide association study also identified GLO1 and a previously unreported gene, ELFN1. A genetic correlation analysis revealed significant common variant overlaps between RLS and neuroticism (rg = 0.40, se = 0.08, p value = 5.4 × 10−7), depression (rg = 0.35, se = 0.06, p value = 2.17 × 10−8), and intelligence (rg = −0.20, se = 0.06, p value = 4.0 × 10−4). Interpretation: Our study expands the understanding of the genetic architecture of RLS, and highlights the contributions of common variants to this prevalent neurological disorder. ANN NEUROL 2024;96:994–1005 [ABSTRACT FROM AUTHOR]

The article reports on the IABSE Annual Meetings held in San Jose in September 2024, marking a return to face-to-face interactions after years of virtual meetings due to the COVID-19 pandemic. The meetings included discussions on management, future plans, technical initiatives, and upcoming events, fostering collaboration and knowledge sharing among members from various countries. The highlight was the election of Dr. Harshavardhan Subbarao from India as the IABSE President for the term 2025-2028, making him the first President from India, with a warm reception following the Permanent Committee meeting. [Extracted from the article]

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Antimicrobial stewardship programs (ASP) often function naturally as facilitators within clinical hospital settings, by working with individuals and teams to reduce unnecessary antibiotics. Within implementation science, facilitation has been studied and evaluated as an implementation strategy that can accelerate and improve fidelity to implementation efforts. This study describes a novel, virtual facilitation strategy developed and served as an intervention within the optimizing perioperative antibiotics for children trial (OPERATIC trial). This paper: (1) describes ASP team's preferences for and use of a facilitation workshop and (2) describes sustained use of facilitation skills throughout the study period. Methods: Study participants included antimicrobial stewardship team members from the nine children's hospitals that participated in this study and completed facilitation training. All individuals who completed facilitation training were asked to evaluate the training through an online survey. Additionally, site leads were interviewed by the site coordinator every other month and asked about their team's use of facilitation skills throughout the rest of the study period. Survey data were managed and coded in R, and qualitative interview data were analyzed using rapid methodology. Results: 30 individuals, including both physicians and pharmacists, completed the evaluation. Individuals largely rated themselves as novice facilitators (53%). Individuals reported satisfaction with virtual facilitation and identified different components of the workshops as valuable. An additional 108 interviews were performed throughout the study period. These interviews found that facilitators reported using all skills throughout the study period and described varied use of skills over time. All nine sites applied facilitation strategies, team building techniques, and communication/conflict skills at some point during the intervention phase. Conclusion: We describe the use of virtual facilitation as an acceptable and appropriate strategy to enhance facilitation skills for ASP teams working to reduce unnecessary postoperative antibiotics. Participants reported different useful components of facilitation training and described using differing facilitation skills throughout the trial. Overall, the use of facilitation skills continued throughout the duration of the study period. This paper outlines how facilitation training can be conducted virtually in a way that is feasible and acceptable to clinicians. Trial registration: NCT04366440, April 24, 2020. [ABSTRACT FROM AUTHOR]

No sooner is an experience over than its neural representation begins to be transformed through memory reactivation during offline periods. The lion's share of prior research has focused on understanding offline reactivation within the hippocampus. However, it is hypothesized that consolidation processes involve offline reactivation in cortical regions as well as coordinated reactivation in the hippocampus and cortex. Using fMRI, we presented novel and repeated paired associates to participants during encoding and measured offline memory reactivation for those events during an immediate post-encoding rest period. post-encoding reactivation frequency of repeated and once-presented events did not differ in the hippocampus. However, offline reactivation in widespread cortical regions and hippocampal-cortical coordinated reactivation were significantly enhanced for repeated events. These results provide evidence that repetition might facilitate the distribution of memory representations across cortical networks, a hallmark of systems-level consolidation. Interestingly, we found that offline reactivation frequency in both hippocampus and cortex explained variance in behavioral success on an immediate associative recognition test for the once-presented information, potentially indicating a role of offline reactivation in maintaining these novel, weaker, memories. Together, our findings highlight that endogenous offline reactivation can be robustly and significantly modulated by study repetition. [ABSTRACT FROM AUTHOR]

OBJECTIVE To compare a commercially available accelerometer, FitBark 2 (FitBark 2nd Generation; FitBark) with a previously validated accelerometer, Actical (Actical; Respironics Inc) during periods of activity and rest. We hypothesized that the FitBark 2 would correlate strongly with the Actical during periods of activity and rest. METHODS 20 dogs between the ages of 1 and 9 years of variable sex, breed, and body weight were enrolled from April through August 2022 in a 1-week pilot trial. Dogs were fitted with a neck collar with both devices mounted on it and wore it continuously for 1 week. Six time points were established to evaluate varying degrees of activity and periods of rest, which included the week, a 1-mile walk, the day of the walk, the hour the walk occurred in, 6 AM to 7 AM on the morning of the walk, and 11 PM to 12 AM on the evening of the walk. Actical and FitBark 2 were compared using linear regression and correlation analysis. RESULTS Correlation analysis revealed a very strong correlation between the Actical and FitBark 2 during the entire week of the study, with a moderate correlation at other time points. Linear regression revealed the strength of the relationship by the r² = 0.85, F1,13 = 76.08. CONCLUSIONS FitBark 2 can be used to evaluate the activity and rest of dogs with varying degrees of correlation when compared to the Actical. CLINICAL RELEVANCE The time period assessed impacts the correlation of the FitBark 2 and Actical. This should be considered when using the FitBark 2 for data collection. [ABSTRACT FROM AUTHOR]

Background: [18F]MK-6240 is a neurofibrillary tangles PET radiotracer that has been broadly used in aging and Alzheimer's disease (AD) studies. Majority of [18F]MK-6240 PET studies use dynamic acquisitions longer than 60 min to assess the tracer kinetic parameters. As of today, no consensus has been established on the optimum dynamic PET scan time. In this study, we assess the reproducibility of [18F]MK-6240 quantitative metrics using shortest dynamic PET protocols in cognitively normal subjects. PET metrics were measured through two-tissue compartment model (2TCM) and Logan model to estimate VT and DVR, as well as SUVR from 90 to 120 min (SUVR90 − 120 min) post-tracer injection for brain regions. 2TCM was carried out using the 120 min dynamic coffee break dataset (first scan from 0 to 60 min p.i., second scan from 90 to 120 min p.i.) and then repeated after stepwise shortening it by 5 min. The dynamic scan length that reproduced the 120 min dynamic scans-based VT to within 10% error was defined as the shortest acquisition time (SAT). The SAT SUVR90 − 120 min was deduced from the SAT dataset by extrapolation of each image pixel time-activity curve to 120 min. The reproducibility of the 120 min dynamic scans-based VT2TCM, DVR2TCM, DVRLogan, and SUVR using the SAT was assessed using Passing-Bablock analysis. The limits of reproducibility of each PET metrics were determined using Bland-Altman analysis. Results: A dynamic SAT of 40 min yielded < 10% error in [18F]MK-6240 VT2TCM's for all brain regions, compared to those measured using the 120 min datasets. SAT-based analysis did not show statistically significant systemic or proportional biases in VT2TCM, DVR2TCM, DVRLogan, or SUVR compared to those deduced from the full dynamic dataset of 120 min. A mean difference between the 120 min- and SAT-based analysis of less than 4%, 10%, 15%, and 20% existed in the VT2TCM, DVR2TCM, DVRLogan, and SUVR respectively. Conclusion: Kinetic modeling of [18F]MK-6240 PET can be accurately performed using dynamic scan times as short as 40 min. This can facilitate studies with [18F]MK-6240 PET and improve patients accrual. Further work would be necessary to confirm the reproducibility of these results for patients in dementia spectra. [ABSTRACT FROM AUTHOR]

The popularity of online shopping in China has increased significantly, creating new development opportunities for the express delivery industry. However, the rapid expansion of the express industry has also created challenges in the parcel sorting process. The demanding nature of parcel sorting work, which is characterized by intense and prolonged repetitive tasks, makes individuals particularly vulnerable to the effects of fatigue. Fatigue is a complex condition that encompasses both physiological and psychological exhaustion. It often results in reduced energy levels and diminished functionality, significantly impacting an individual's performance at work and their overall well-being. This study aimed to investigate how physiological and psychological fatigue affects sorting efficiency and to identify appropriate rest periods that will allow employees to maintain their performance levels. The research involved fifteen participants who took part in a 60 min continuous sorting experiment and a similar experiment with scheduled breaks. During both trials, we collected data on participants' electromyography (EMG) and electrodermal activity (EDA), as well as subjective fatigue ratings (RPE). Signal features such as the median frequency (MF) of EMG and the skin conductance level (SCL) were analyzed to assess physiological and psychological fatigue, respectively. The results show that physiological fatigue mainly affects sorting efficiency in the first 30 min, while psychological fatigue becomes more influential in the following half-hour period. In addition, subjective fatigue levels during the first 30 min are primarily determined by psychological factors, while beyond that point, both physiological and psychological fatigue contribute to subjective fatigue. Rest periods of 415–460 s, based on EDA recovery times, effectively support sorting efficiency and participants' recovery. This study highlights the complex ways in which fatigue affects parcel sorting performance and provides valuable theoretical and practical insights for establishing labor quotas and optimizing work schedules in the parcel sorting industry. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of the present study was to compare the acute effects of different rest period durations after general warm-up (GWU) and dynamic stretching (DS) on endurance running performance. Methods: Eight male runners performed endurance running performance tests after three types of intervention. The interventions were as follows: (1) GWU + 5 min Rest, (2) GWU + DS + 5 min Rest, and (3) GWU + DS + 10 min Rest. The GWU consisted of running exercises on a treadmill at a velocity equivalent to 70% of maximum oxygen uptake (V̇O2max) for 15 min. The DS consisted of performing 10 repetitions as quickly as possible for the five muscle groups of the lower extremities. Endurance running performance was measured by time to exhaustion (TTE) during running on the treadmill at a velocity equivalent to 90% V̇O2max. Results: TTE (884.5 ± 244.9 s) after GWU + DS + 10 min Rest intervention was significantly (p < 0.05) longer than that (719.8 ± 227.9 s) after GWU + 5 min Rest. TTE (734.5 ± 274.2 s) after GWU + DS + 5 min Rest intervention was not significantly different than that of the other two interventions. Conclusion: The results demonstrated that the endurance running performance at the velocity equivalent to 90% V̇O2max was enhanced by GWU + DS + 10 min Rest, but not GWU + DS + 5 min Rest. We recommend that runners rest for approximately 10 min after GWU + DS to enhance endurance running performance. [ABSTRACT FROM AUTHOR]

This study presents a novel real-time prediction technique for multi-degree-of-freedom ship motion and resting periods utilizing Long Short-Term Memory (LSTM) networks. The primary objective is to enhance the safety and efficiency of shipborne helicopter landings by accurately predicting heave, pitch, and roll data over an 8 s forecast horizon. The proposed method utilizes the LSTM network's capability to model complex nonlinear time series while employing the User Datagram Protocol (UDP) to ensure efficient data transmission. The model's performance was validated using real-world ship motion data collected across various sea states, achieving a maximum prediction error of less than 15%. The findings indicate that the LSTM-based model provides reliable predictions of ship resting periods, which are crucial for safe helicopter operations in adverse sea conditions. This method's capability to provide real-time predictions with minimal computational overhead highlights its potential for broader applications in marine engineering. Future research should explore integrating multi-model fusion techniques to enhance the model's adaptability to rapidly changing sea conditions and improve the prediction accuracy. [ABSTRACT FROM AUTHOR]

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Small talk plays a big role in conversational perception. In the study here, pairs of conversational participants engaged in three iterations of an ecologically valid task-break dialogue where the break was either small talk via videoconferencing or waiting the same amount of time with cameras and mics turned off. Small talk increased conversational participants’ enjoyment of conversations, their willingness to engage in future conversations with their addressees, and their actual engagement in unprompted conversations with their addressees. Dyads who were instructed to engage in small talk conversation during breaks were approximately three and a half times more likely to have conversations in the sixty second unprompted conversation period at the end of the study compared to dyads whose cameras and mics were off during the earlier break periods. Reciprocity effects previously observed in audio-only and text-only communication were not observed in this study. The findings presented here demonstrate that not only can the positive influence of small talk be replicated and extended to videoconferencing interactions, but such talk can also lead to an increased desire for continued interactions with conversational partners. [ABSTRACT FROM AUTHOR]

We systematically searched the literature for studies with a randomized design that compared different inter-set rest interval durations for estimates of pre-/post-study changes in lean/muscle mass in healthy adults while controlling all other training variables. Bayesian meta-analyses on non-controlled effect sizes using hierarchical models of all 19 measurements (thigh: 10; arm: 6; whole body: 3) from 9 studies meeting inclusion criteria analyses showed substantial overlap of standardized mean differences across the different inter-set rest periods [binary: short: 0.48 (95%CrI: 0.19-0.81), longer: 0.56 (95%CrI: 0.24-0.86); Four categories: short: 0.47 (95%CrI: 0.19-0.80), intermediate: 0.65 (95%CrI: 0.18-1.1), long: 0.55 (95%CrI: 0.15-0.90), very long: 0.50 (95%CrI: 0.14-0.89)], with substantial heterogeneity in results. Univariate and multivariate pairwise meta-analyses of controlled binary (short vs. longer) effect sizes showed similar results for the arm and thigh with central estimates tending to favor longer rest periods [arm: 0.13 (95%CrI: -0.27 to 0.51); thigh: 0.17 (95%CrI: -0.13 to 0.43)]. In contrast, central estimates closer to zero but marginally favoring shorter rest periods were estimated for the whole body [whole body: -0.08 (95%CrI: -0.45 to 0.29)]. Subanalysis of set end-point data indicated that training to failure or stopping short of failure did not meaningfully influence the interaction between rest interval duration and muscle hypertrophy. In conclusion, results suggest a small hypertrophic benefit to employing inter-set rest interval durations >60 s, perhaps mediated by reductions in volume load. However, our analysis did not detect appreciable differences in hypertrophy when resting >90 s between sets, consistent with evidence that detrimental effects on volume load tend to plateau beyond this time-frame. [ABSTRACT FROM AUTHOR]

Blood flow restriction (BFR) has been identified as a potential countermeasure to mitigate physiological deconditioning during spaceflight. Guidelines recommend that tourniquet pressure be prescribed relative to limb occlusion pressure (LOP); however, it is unclear whether body tilting or reduced gravity analogues influence LOP. We examined LOP at the leg and arm during supine bedrest and bodyweight suspension (BWS) at 6° head‐down tilt (HDT), horizontal (0°), and 9.5° head‐up tilt (HUT) positions. Twenty‐seven adults (age, 26 ± 5 years; height, 1.75 ± 0.08 m; body mass, 73 ± 12 kg) completed all tilts during bedrest. A subgroup (n = 15) additionally completed the tilts during BWS. In each position, LOP was measured twice in the leg and arm using the Delfi Personalized Tourniquet System after 5 min of rest and again after a further 5 min. The LOP at the leg increased significantly from 6° HDT to 9.5° HUT in bedrest and BWS by 9–15 mmHg (Cohen's d = 0.7–1.0). Leg LOP was significantly higher during BWS at horizontal and 9.5° HUT postures relative to the same angles during bedrest by 8 mmHg (Cohen's d = 0.6). Arm LOP remained unchanged between body tilts and analogues. Intraclass correlation coefficients for LOP measurements taken after an initial and subsequent 5 min rest period in all conditions ranged between 0.91–0.95 (leg) and 0.83–0.96 (arm). It is advised that LOP be measured before the application of a vascular occlusion in the same body tilt/setting to which it is applied to minimize discrepancies between the actual and prescribed tourniquet pressure. [ABSTRACT FROM AUTHOR]

Perspiration plays a pivotal role not only in thermoregulation but also in reflecting the body's internal state and its response to external stimuli. The up‐to‐date skin‐based wearable platforms have facilitated the monitoring and simultaneous analysis of sweat, offering valuable physiological insights. Unlike conventional passive sweating, dynamic normal perspiration, which occurs during various activities and rest periods, necessitates a more reliable method of collection to accurately capture its real‐time fluctuations. An innovative microfluidic patch incorporating a hierarchical superhydrophilic biosponge, poise to significantly improve the efficiency capture of dynamic sweat is introduced. The seamlessly integrated biosponge microchannel showcases exceptional absorption capabilities, efficiently capturing non‐sensitive sweat exuding from the skin surface, mitigating sample loss and minimizing sweat volatilization. Furthermore, the incorporation of sweat‐rate sensors alongside a suite of functional electrochemical sensors endows the patch of uninterrupted monitoring and analysis of dynamic sweat during various activities, stress events, high‐energy intake, and other scenarios. [ABSTRACT FROM AUTHOR]

Brain–computer interfaces (BCIs) are pivotal in translating neural activities into control commands for external assistive devices. Non-invasive techniques like electroencephalography (EEG) offer a balance of sensitivity and spatial-temporal resolution for capturing brain signals associated with motor activities. This work introduces MOVING, a Multi-Modal dataset of EEG signals and Virtual Glove Hand Tracking. This dataset comprises neural EEG signals and kinematic data associated with three hand movements—open/close, finger tapping, and wrist rotation—along with a rest period. The dataset, obtained from 11 subjects using a 32-channel dry wireless EEG system, also includes synchronized kinematic data captured by a Virtual Glove (VG) system equipped with two orthogonal Leap Motion Controllers. The use of these two devices allows for fast assembly (∼1 min), although introducing more noise than the gold standard devices for data acquisition. The study investigates which frequency bands in EEG signals are the most informative for motor task classification and the impact of baseline reduction on gesture recognition. Deep learning techniques, particularly EEGnetV4, are applied to analyze and classify movements based on the EEG data. This dataset aims to facilitate advances in BCI research and in the development of assistive devices for people with impaired hand mobility. This study contributes to the repository of EEG datasets, which is continuously increasing with data from other subjects, which is hoped to serve as benchmarks for new BCI approaches and applications. [ABSTRACT FROM AUTHOR]

Post-stroke gait asymmetry leads to inefficient gait and a higher fall risk, often causing limited home and community ambulation. Two types of treadmills are typically used for training focused on symmetry: split-belt and single belt treadmills, but there is no consensus on which treadmill is superior to improve gait symmetry in individuals with stroke. To comprehensively determine which intervention is superior, we considered multiple spatial and temporal gait parameters (step length, stride time, swing time, and stance time) and their symmetries. Ten individuals with stroke underwent a single session of split-belt treadmill training and single belt treadmill training on separate days. The changes in step length, stride time, swing time, stance time and their respective symmetries were compared to investigate which training improves both spatiotemporal gait parameters and symmetries immediately after the intervention and after 5 min of rest. Both types of treadmill training immediately increased gait velocity (0.08 m/s faster) and shorter step length (4.15 cm longer). However, split-belt treadmill training was more effective at improving step length symmetry (improved by 27.3%) without sacrificing gait velocity or step length. However, this step length symmetry effect diminished after a 5-min rest period. Split-belt treadmill training may have some advantages over single belt treadmill training, when targeting step length symmetry. Future research should focus on comparing the long-term effects of these two types of training and examining the duration of the observed effects to provide clinically applicable information. [ABSTRACT FROM AUTHOR]

Stockpiling forage (i.e., deferring grazing) is one way to provide forage for livestock during intervals of low pasture growth, but there are trade-offs as nutrient content declines with increasing forage maturity. Phosphorous (P) concentration, crude protein (CP) content and organic matter digestibility (OMD) were evaluated in two C3 and four C4 grasses native to the South American Campos grasslands. These were: Bromus auleticus (BROAUL) and Nasella neessiana (NASNEE) as C3 grasses and Andropogon lateralis (ANDLAT), Mnesithea selloana (MNESEL), Paspalum dilatatum (PASDIL), and Paspalum notatum (PASNOT) as C4 grasses. The grasses were grown in pots during five stockpiling periods (450, 900, 1350, 1800 and 2250 degree days, approximately 20, 40, 60, 80 and 100 days). As the forage deferment increased, the nutritional value decreased more in C4 than in C3 grasses. Short rest periods (approximately 40 days) are recommended for PASDIL and MNESEL, and medium rest periods (approximately 80 days) for ANDLAT and PASNOT. However, the C3 grasses BROAU and NASNEE maintained high P and CP concentrations and may be the most appropriate option for long rest periods (≥100 days). This information is important to manage different Campos grassland communities for the optimal rest period according to the dominant species. [ABSTRACT FROM AUTHOR]

Ultradian rhythms of metabolism, body temperature and activity are attenuated or disappear completely during torpor in Djungarian hamsters, for all three ultradian periodicities (URsmall, URmedium and URlarge). URsmall and URmedium disappear during entrance into torpor, whereas URlarge disappear later or continue with a low amplitude. This suggests a tight functional link between torpor and the expression of ultradian rhythms, i.e. torpor is achieved by suppression of metabolic rate as well as silencing of ultradian rhythms. Spontaneous torpor is often initiated after an ultradian burst of activity and metabolic rate, beginning with a period of motionless rest and accompanied by a decrease of metabolic rate and body temperature. To extend previous findings on the potential role of the adrenergic system on torpor induction we analysed the influence of the ß3-adrenergic agonist Mirabegron on torpor in Djungarian hamsters, as compared to the influence of the ß-adrenergic antagonist Propranolol. Hamsters were implanted with 10 day release pellets of Mirabegron (0.06 mg day−1) or Propranolol (0.3 mg day−1). Mirabegron transiently supressed and accelerated ultradian rhythms but had no effect on torpor behaviour. Propranolol did not affect torpor behaviour nor the expression of ultradian rhythms with the dosage applied during this study. [ABSTRACT FROM AUTHOR]

We aimed to investigate the impact of smartphone use during intertrial intervals within a distributed practice regime on mental fatigue, performance, and learning of a balance motor skill. One hundred and thirty-six participants were randomly divided into two groups: the smartphone use group (SMARTPHONE) and the control group (CONTROL). The SMARTPHONE accessed social media during the rest periods within a distributed practice of a balance task, whereas the CONTROL rested passively during the rest periods. The participants practiced the toe-touch task. The participants underwent a pretest consisting of one trial. Subsequently, the participants were engaged in practice, completing six trials interspersed with 2-min intervals of either rest or smartphone use. Following the practice phase, a posttest was conducted, and after 24 hr, we administered a retention test and a transfer test. The number of touches and the number of errors (contacting the ground with the free leg to regain balance) were performance measures. We evaluated the participants' mental fatigue after the practice session using a visual analog scale. The groups demonstrated similar mental fatigue after practice. Our results suggest that using social media on smartphones during rest periods within a distributed practice impairs performance but not motor learning. [ABSTRACT FROM AUTHOR]

The relaxation self-oscillations of the Mackey–Glass equation are studied under the assumption that the exponent in the nonlinearity denominator is a large parameter. We consider the case where the limit relay equation, which arises as the large parameter tends to infinity, has a periodic solution with the smallest number of breaking points on the period. In this case, we prove the existence of a periodic solution of the Mackey–Glass equation that is asymptotically close to the periodic solution of the limit equation. [ABSTRACT FROM AUTHOR]

An in-depth analysis of the reading challenges encountered by kids in second grade, the factors that amplify these challenges, and the strategies used by second grade teachers to address these concerns are the primary goals of this research. A qualitative research technique is used in this study. The method used is qualitative descriptive analysis. The research included both the students and teachers of Class II. Methods of data collection for this research include recording, observing, and interviewing participants. Based on the findings of this research, second graders often struggle with reading because they either do not know the letters yet, have trouble stringing them into words, leave out letters when reading, stutter when reading, or pronounce them backwards. replace "u" with "n" or "b" with "d". Students' poor memorization skills and a lack of parental instruction at home are the limiting variables that contribute to their reading challenges. Teachers adopt the method of giving students who struggle with reading and learning media more time to read at break periods on a rotating basis. [ABSTRACT FROM AUTHOR]

Functional magnetic resonance imaging (fMRI) is a noninvasive and in-vivo imaging technique essential for measuring brain activity. Functional connectivity is used to study associations between brain regions, either while study subjects perform tasks or during periods of rest. In this paper, we propose a rigorous definition of task-evoked functional connectivity at the population level (ptFC). Importantly, our proposed ptFC is interpretable in the context of task-fMRI studies. An algorithm for estimating the ptFC is provided. We present the performance of the proposed algorithm compared to existing functional connectivity frameworks using simulations. Lastly, we apply the proposed algorithm to estimate the ptFC in a motor-task study from the Human Connectome Project. [ABSTRACT FROM AUTHOR]

Background: Isometric handgrip (IHG) exercises can be a simple tool and an effective, time-consumable test that may be beneficial for blood pressure (BP) regulation. Hypertension prevention or BP control is necessary nowadays. Isometric exercise evokes the contractions of skeletal muscle without altering their length, but changes in the tension of the muscle occur. Through lifestyle modification, static exercises maintain the desired BP in individuals other than aerobic exercises. Aims and Objectives: The aim of the study was to evaluate the effective changes of isometric handgrip exercise on young, healthy subjects and determine changes in heart rate (HR) and BP before and after exercise. Materials and Methods: A randomized controlled study has been conducted in the department of physiology at JMC Rajasthan for 3 months. The study sample included 72 volunteer subjects (40 male and 32 females) aged 19-25 years, and handgrip spring dynamometer was used for isometric handgrip exercise (IHE) training exercise training. The IHE training group performed handgrip exercises for 3 months at 30% of their maximum isometric contraction, 3 times/week for five 3-min bouts with 5-min rest periods between each bout. Before and after the intervention, BP and HR were measured. P-value was advised significant at 0.05. Results: At the completion of 3 months of IHE exercise training, significant changes are seen in HR and BP in all healthy volunteers (P < 0.001 for all forms of BP) (HR, P = 0.014). In female volunteer and diastolic BP, it decreases significantly, but no significant changes are seen in systolic BP, mean arterial pressure, and HR. Conclusion: IHG exercise training reduces or regulates baseline BP and HR and explores the potential of this intervention for managing or preventing hypertension. [ABSTRACT FROM AUTHOR]

During rest periods, bedload tracers can be buried, while transport can move them to locations with different bed shear stresses or a different riverbed composition. This affects the mobility of the tracers compared to that of the bedload at the location where the tracers were seeded and has so far limited the explanatory power of field tracer studies on the virtual bedload velocity. This paper proposes a method to assess both the unsteady virtual tracer velocity and the unsteady virtual bedload velocity from field tracer studies. First, the virtual bedload velocity was conceptualized as the velocity of a relay run and contrasted with the velocity of the decelerating runs of bedload tracers. Then, a regression method for deriving the unsteady virtual velocity of bedload tracers was extended to account for tracer slowdown by including a corresponding function of the distance traveled. Finally, data from 65 bedload tracers in the Upper Drava River with very‐high‐frequency (VHF) transmitters were used for method testing. By linking the measured tracer mobility to the hydraulics and bed surface grain size near the seeding location, it was possible to determine the unsteady bedload velocity function as the unsteady tracer velocity function at a travel distance of zero. The tracer travels exhibited increasing slowdown effects with increasing tracer grain size, probably due to the dominant role of advection effects at the study site. The derivation of the bedload velocity ensures comparability to laboratory results and between tracer studies. Key Points: Gaps between laboratory and field are bridged by basing bedload tracer analyses on theories from laboratory and considering slowdownUnderstanding the bedload velocity as that of a relay run as opposed to that of individual tracer runs allowed deriving the bedload velocityThe derived formulas describe well the transport of bedload tracers with measured travel distances reaching more than 30 km [ABSTRACT FROM AUTHOR]

Background: Evidence suggests that aerobic training with blood flow restriction is beneficial for treating fibromyalgia. This study evaluated the feasibility, safety, and effects of an aerobic training program with blood flow restriction for women with fibromyalgia. Methods: Thirty-seven women with fibromyalgia were included, and thirteen with an average age of 59 ± 3, a BMI of 26 ± 3, and who were polymedicated started the intervention period. The intervention group performed aerobic exercise with blood flow restriction using occlusive bands placed in the upper part of the rectus femoris, with a total duration of 14 min of restriction divided into two periods of 7 min with a rest period of 3 min and a total session duration of 17 min. Pressure intensity was measured using the visual pain scale (VAS), scoring 7 out of 10 (n = 7). The non-intervention group performed aerobic exercise without restriction of blood flow for the same periods, rest periods, and total duration of the session (n = 6). The intervention included 2 weekly sessions with 72 h between aerobic walking for 9 weeks. Walking was measured individually using the rating of perceived exertion scale (RPE) with an intensity between 6 and 7 out of 10. Visual and verbal support for the VAS and RPE scale was always provided throughout the sessions supervised by the investigator. Functional capacity was assessed using tests (six-minute walk test, incremental shuttle walk test, knee extension and handgrip test by dynamometer, 30 s chair stand test, and timed up-and-go test). Symptomatology was assessed using questionnaires (Widespread Pain Index, Symptom Severity Score, Fibromyalgia Impact Questionnaire, and Multidimensional Fatigue Inventory), and blood samples were collected. Results: There were no adverse effects, and only one participant in the intervention group withdrew. Between-group and intragroup differences showed that the intervention group obtained improvements in the functional tests; CST p = 0.005; 6MWT p = 0.011; Handgrip p = 0.002; TUGT p = 0.002 with reduced impact of the disease according to the questionnaires; FIQ Stiffness p = 0.027 compared with the nonintervention group. Biochemical results remained within normal ranges in both groups. Conclusions: Blood flow-restricted aerobic training may be feasible, safe, and more effective than unrestricted aerobic training as a physical exercise prescription tool to improve cardiorespiratory fitness, strength, balance, and stiffness in women with fibromyalgia. [ABSTRACT FROM AUTHOR]

This paper presents the concept of applying incremental capacity analysis (ICA) on the OCV curve in the SoC space. The OCV curve can be obtained from any sequence of discharge or charge current or power pulse with a necessary rest period to allow the cell to reach a pseudo-OCV after each pulse. With a high resolution (>100 pulses) in the full SoC window, an OCV-vs.-SoC curve can be obtained with sufficient accuracy to perform an ICA on the obtained OCV curve. ICA as a diagnostic technique has commonly been applied on Li-ion cells with constant charge and discharge at slow currents. However, a slow controlled constant current charge or discharge is normally not feasible and cannot be easily applied to a battery in an application. Here, we revisit pulse-based ICA to supplement the conventional constant-current-based technique. Based on actual ageing data, we show that ICA performed on a selection of high-resolution OCV curves is comparable or better than conventional ICA with constant current. The main advantage of OCV-ICA is that it can be applied to most cells and systems without a significant interruption of normal cell operation. OCV-ICA can provide valuable insights into ageing mechanisms as well as, e.g., detailed information on changes in internal resistance. [ABSTRACT FROM AUTHOR]

This paper presents new mixed-integer linear programming formulations for multi-activity shift scheduling problems (MASSP). In these formulations, the rules governing shift feasibility are encoded in block-based state-expanded networks in which nodes are associated with states and arcs represent assignments of blocks of work or break periods inducing state transitions. A key advantage of these formulations is that for the anonymous MASSP in which all employees are considered as equal only a single network with integer flow variables is needed as long as the network encodes all shift composition rules. A challenging aspect is that the networks can become very large, yielding huge models that are hard to solve for large problem instances. To address this challenge, this paper proposes two exact modeling techniques that substantially reduce the size of the model instances: First, it introduces a set of aggregate side constraints enforcing that an integer flow solution can be decomposed into paths representing feasible shifts. Second, it proposes to decouple the shift composition from the assignment of concrete activities to blocks of work periods, thereby removing a large amount of symmetry from the original model. In a computational study with two MASSP instance sets from the literature dealing with shift scheduling problems, we demonstrate the effectiveness of these techniques for reducing the both size of the model instances and the solution time: We are able to solve all instances, including more than 70 previously open instances, to optimality–the vast majority of them in less than 30 min on a notebook computer. [ABSTRACT FROM AUTHOR]

It is probable that resilience can play a significant role in mitigating the impact of job burnout on workplace safety outcomes. Identification of these relations and paths can be useful for reducing burnout effects and reinforcing safety behavior factors. This study seeks to explore the relationship between job burnout and unsafe behavior, with a specific focus on the mediating role of resilience. This cross-sectional study, conducted in 2023, involved 200 workers in the spinning and weaving industries in central Iran. The study used printed questionnaires distributed to study participants during their rest periods to collect data for further analysis. The questionnaires included demographic information, the Maslach burnout inventory, the Connor–Davidson Resilience Scale, and a set of safety behavior questionnaires. Subsequently, the study analyzed various dimensions of job burnout with respect to unsafety behavior by constructing a theoretical model using AMOS software. The results indicate that three burnout dimensions indirectly influence safety compliance through resilience (P < 0.001). Specifically, depersonalization and personal accomplishment directly and indirectly affect safety participation through resilience and safety compliance (P < 0.001). Resilience had the highest direct and total effect coefficients on safety compliance (0.692 and 0.692), while emotional exhaustion exhibited the highest indirect coefficients (− 0.505). Regarding safety participation, the highest direct coefficient was associated with personal accomplishment (0.406), and the greatest indirect and total coefficients with depersonalization (− 0.370 and − 0.588). By recognizing the differential impacts of various burnout dimensions, tailored interventions can be developed to address specific facets of burnout, thus optimizing safety initiatives. Moreover, the pivotal role of resilience unveils a promising avenue for mitigating the adverse effects of burnout on unsafe behaviors. [ABSTRACT FROM AUTHOR]

Highlights: What are the main findings? The effect of resting time on asphalt adhesion was most pronounced in comparison to temperature and spalling agent dosage. What is the implication of the main finding? A combined micro- and macro-scale investigation was conducted to ascertain the impact of varying static conditions on the tensile properties of asphalt concrete. This study addresses the issue of construction stagnation affecting the adhesion and tensile properties of hydraulic asphalt concrete with acid aggregate. It investigates the impact of rest periods on the tensile characteristics of such materials under standard construction conditions. The influence of varying rest durations and asphalt temperatures on the tensile behavior of the concrete is assessed through indoor experiments. The bonding between asphalt and aggregate is examined, along with the tensile property variations of the concrete. The study found that the standstill time significantly affects the adhesion of asphalt, with the adhesion decreasing progressively with increased temperature and rest time, irrespective of the addition of anti-stripping agents. However, the inclusion of these agents can mitigate the reduction in adhesion. Furthermore, the study identified that rest duration has a more substantial impact on adhesion than temperature. The splitting tests demonstrate that the tensile properties of asphalt concrete are considerably affected by the resting time. Over a period of 0, 10, 20, and 30 days of rest, an increase in splitting strength and a decrease in splitting displacement were observed. The findings offer valuable insights for predicting the tensile performance of asphalt concrete in practical engineering applications after a period of rest. [ABSTRACT FROM AUTHOR]

The ecosystems across the world are affected by diverse impacts of climate change. Climate change will also affect soil seed bank as the seed bank is determined by the plants that are above the ground. This study was conducted to determine whether rainfall interception and resting period will affect the soil seed bank or not. Rainfall interception was employed as main plot treatment at four different levels--namely, 15%, 30%, 60%, and 0%--and the main plot treatments were each replicated five times using the rainout shelters arranged as main plot treatments in a split-plot experimental design. The main plots are 49 m² (7 m × 7 m) in size and were covered by metal frame structures with Vshaped clear acrylic bands on top without ultraviolet filter, and these plots were sub-divided into two sub-plots to determine the effect of resting periods (70 and 90 days). The soil samples were 8 cmin diameter and 20 cm in depth (1,005 cm³). We used seed emergence method rather than seed separation method to determine the soil seed bank due to the very small size of some seeds for some species. The 60% rainfall interception resulted in significantly high forb densities at both resting periods. The forb densities decreased by 32 and 35% at 15% and 30%, while they increased by 195% at 60% rainfall interception compared to 0% rainfall interception at 70-day resting period. Resting period significantly affected grass densities at 60% rainfall as the densities were higher at 70-than 90-day resting period. At 90-day resting period, grass densities were significantly higher at 0% rainfall interception than the rest of the treatments, while the grass densities were significantly lower at 60% rainfall interception. The 60% rainfall interception resulted in significantly (p< 0.05) higher total densities (forbs and grass) in both resting periods. Total density increased by 2.9% and 143.48% at 15% and 60% rainfall interception, respectively. Our results show that drought has a negative effect on grass soil seed bank, while it improves the forbs soil seed bank. Furthermore, the resting period has no significant effects on soil seed bank in grasslands. [ABSTRACT FROM AUTHOR]

The objective of this study was to investigate the effects of feeding surplus dairy calves a milk replacer (MR) or one of 2 different oral rehydration solutions (ORS) during a midtransportation rest period on metabolic and clinical health indicators, growth, and behavioral outcomes after arrival at a calf-raising facility. Surplus dairy calves (n = 128) were transported in 4 cohorts from February to July 2022 for 12 h to a holding facility, rested for 8 h, then transported for an additional 6 h to a calf-raising facility. Upon arrival at the holding facility, calves were randomly assigned to 1 of 3 treatments: MR (n = 43), a high-sodium ORS developed for diarrhea (ORS-D; n = 43), or a high-potassium ORS developed for transportation (ORS-T; n = 42). The exact age of calves at transportation was unknown; however, all calves were less than 14 d of age. Calf BW at enrollment was 43.9 ± 5.9 kg, 43.7 ± 6.5 kg, and 45.0 ± 4.5 kg for calves fed MR, ORS-D, and ORS-T, respectively. Calves were fed 2.0 L of their treatment twice, once upon arrival and once before leaving the holding facility. At unloading and reloading at the holding facility, calves were weighed and blood samples were obtained. Calves were also health scored at unloading at the holding facility. After arrival at the calf-raising facility, calves were weighed, health scored, and blood samples were taken. Blood samples were collected at 24 and 48 h and BW was recorded at 24 h, 48 h, 72 h, 5 d, 7 d, 14 d, and at 8 wk after arrival at the calf-raising facility. Calves were also health scored daily for 14 d; health scoring included fecal consistency scoring and evaluating the presence or absence of respiratory disease. Lying time, lying bouts, and activity index were measured during transportation and from 3 d relative to transportation using accelerometers. At arrival to the calf-raiser, calves fed ORS-D had higher concentrations of nonesterified fatty acids (NEFA) and BHB than calves fed MR. Furthermore, calves fed ORS-T had higher concentrations of BHB at arrival to the calf raiser compared with calves fed MR. In the 14 d after arrival at the calf-raiser, there was evidence that calves fed ORS-T had a higher proportion of days with diarrhea and respiratory disease compared with those fed MR. During transportation, calves fed ORS-T had a lower activity index than calves fed MR, suggesting that ORS-T calves had lower overall activity. In addition, on the day of transportation (d 0), ORS-T and ORS-D calves had a lower activity index than calves fed MR. There were no treatment effects on growth outcomes. The results of this study suggest that feeding MR rather than an ORS during a midtransportation rest period could minimize fat mobilization and can potentially improve diarrhea and respiratory disease but does not affect growth outcomes after arrival at calf-raisers. [ABSTRACT FROM AUTHOR]

This article discusses the welfare considerations for managing horses on prolonged periods of box rest. The authors highlight the importance of considering the horse's perspective and mental state when assessing welfare. They suggest various strategies for improving welfare, such as providing companionship, training, environmental enrichment, and the use of psychopharmaceuticals. The article emphasizes the need for individualized treatment plans and involving the owner in decision-making. Overall, the authors stress the importance of minimizing the negative impact on the horse's mental health while ensuring their physical health and safety during confinement and restricted exercise. [Extracted from the article]

Despite an established body of research characterizing how creative individuals explore their external world, relatively little is known about how such individuals navigate their inner mental life, especially in unstructured contexts such as periods of awake rest. Across two studies, the present manuscript tested the hypothesis that creative individuals are more engaged with their idle thoughts and more associative in the dynamic transitions between them. Study 1 captured the real-time conscious experiences of 81 adults as they voiced aloud the content of their mind moment-by-moment across a 10-minute unconstrained baseline period. Higher originality scores on a divergent thinking task were associated with less perceived boredom, more words spoken overall, more freely moving thoughts, and more loosely-associative (as opposed to sharp) transitions during the baseline rest period. In Study 2, across 2,612 participants, those who reported higher self-rated creativity also reported less perceived boredom during the COVID-19 pandemic, a time during which many people experienced unusually extended periods of unstructured free time. Overall, these results suggest a tendency for creative individuals to be more engaged and explorative with their thoughts when task demands are relaxed, raising implications for resting state functional MRI and societal trends to devalue idle time. [ABSTRACT FROM AUTHOR]

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The dusky grouper (Epinephelus marginatus) is a vulnerable predatory fish found in the Atlantic and Indian oceans, and in the Mediterranean Sea. This study investigates the movement patterns of grouper larvae (151 individuals) during their first feeding period (three to ten days post hatching) through laboratory experiments offering rotifers (Brachionus sp.) and copepod nauplii as food. High-speed cameras and imaging techniques including bright field microscopy, matched filters, and holography captured rapid displacements (up to 25 body lengths per second), peduncle caudal beats (up to 40 beats s−1), turns, and resting periods. Reynolds numbers ranged from <45 for routine swimming to 222 for burst swimming. Specific behaviors, including changes in swimming velocity and body movements, were observed from three days post hatching, when feeding begins, suggestive of an array of responses to environmental forcing, predator avoidance, food search, and feeding success. These findings provide insights into the critical movement performances of E. marginatus larvae, which help to unravel their ecological interactions and survival strategies. Understanding grouper larval swimming behavior is pivotal for devising effective cultivation strategies aimed at replenishing wild stocks and enhancing production for human consumption. [ABSTRACT FROM AUTHOR]

Because of the climatological prevalence of hot, humid conditions, moist heat extremes are a significant challenge to the health and wellbeing of the people in India. While research has demonstrated the importance of summer monsoon to moist heat in India, impact of monsoon‐break and warm spells in modulating extreme moist heat regionally has not been fully investigated. Here we investigate moist heat extremes, as measured by the Wet‐Bulb Globe Temperature (WBGT) metric, specifically during monsoon and monsoon‐break periods and find that they pose a major threat to physical labor and health relative to other seasons. During the 1951–2020 break period, an increase in area exposed (∼42.76 million km2), representing at least 670 million people, to extreme and detrimental WBGT values >31°C occur. Our results imply that future studies on extreme moist heat must pay close attention to the variation of weather systems on synoptic to subseasonal time scales that are superimposed on the seasonal monsoon migration. Plain Language Summary: A significant increase in temperature extremes associated with high humidity has been observed recently in India. While the Indian population is susceptible to moist heat owing to the current agricultural sector, the recent rise in construction employment can exacerbate its impact. Prolonged exposure to elevated moist heat during any period can lead to a health hazard that can be fatal during certain climatic conditions. We show that India has been exposed to dangerous levels of moist heat during monsoon‐break, significantly affecting millions of people. While moist heat extremes occur during monsoon‐breaks, it's recent rise is primarily due to global warming. Additionally, the risk associated with the rise in monsoon‐break moist heat is substantially higher than other seasons in India. Our findings have implications for public health and subsequent policy development. In recent decades, the increasing agricultural and construction activities in India have drawn immediate attention to policy revision in outdoor working hours. Key Points: Extreme monsoon‐break moist heat is detrimental to physical labor relative to other seasons in the Indian regionThe substantial rise in extreme moist heat has contributed to elevated risk and population exposure over the countryRising global temperature drives extreme moist heat during the monsoon‐break, similar to regional temperature change [ABSTRACT FROM AUTHOR]

Background: The aim of the present study was to compare the effects of resistance training through full range of motion and static stretching (SS) of the hip and lower back extensors on flexibility and strength in healthy, physically active, adults. Methods: Eighteen participants (age: 24.2 ± 3.0 years, body mass: 71.3 ± 8.9 kg, height: 172.8 ± 7.5 cm) were randomly assigned to either a Resistance Training (RT) (n = 6), SS (n = 6), or control (CON) group (n = 6). The sit & reach (S&R) flexibility test and maximum isometric straight legged deadlift (ISLDL) at 95% and 50% range of motion (ROM) were tested pre- and post-intervention with significance set at p < 0.05. Both groups conducted four to eight sets per session. Within each set, the RT group performed eight repetitions each lasting four seconds, while the SS group stretched continuously for 32 s. The rest periods between each set were 60–90 s. Consequently training volume and rest times were matched between the groups. Results: The RT and SS groups achieved significant, large magnitude improvements in the S&R test compared to the CON group (p < 0.01 g = 2.53 and p = 0.01, g = 2.44), but no differences were observed between the RT and SS groups (p = 1.00). Furthermore, the RT group demonstrated a larger improvement in 50% and 95% ROM ISLDL compared to SS (p < 0.01, g = 2.69–3.36) and CON (p < 0.01, g = 2.44–2.57). Conclusion: Resistance training through a full ROM was equally effective as SS for improving S&R flexibility, but improved hip- and lower back extensor strength more than SS and the CON. The authors recommend using large ROM resistance training to improve hip and lower back extensor flexibility and muscle strength. Trial registration: ISRCTN88839251, registered 24. April 2024, Retrospectively registered. [ABSTRACT FROM AUTHOR]

Understanding how animals respond to stressors is critical for effective conservation. The present study aimed to evaluate the physiological recovery of the Shortnose Guitarfish, Zapteryx brevirostris after being incidentally captured by artisanal fleets and compared it to guitarfish with delayed mortality. Moreover, the study aimed to test the efficiency of a rehabilitation protocol for the species. To this end, individuals landed alive were transported to the rehabilitation facilities and kept in tanks under monitoring for 3 days. Physiological markers indicative of allostatic overload (i.e., lactate and phosphorus) and energy metabolism (i.e., glucose and β‐hydroxybutyrate) were assessed in the serum of the studied guitarfish: right after gillnet capture (i.e., post‐capture) and on rehabilitation (i.e., pre‐monitoring, post‐monitoring, as well as guitarfish that deceased during monitoring – post‐mortem). Results showed that the transportation and additional handling employed in the rehabilitation protocol did not increase the stress response, pointing to its potential efficacy in recovering debilitated, incidentally caught guitarfish before release. As for recovery success of monitored guitarfish, lactic acidosis was fully reverted after a 3‐day rest period, as was allostatic overload. The same was not observed in recovery failure. Correlation tests revealed key relationships between physiological markers, shedding light on how physiological pathways help guitarfish cope with capture and handling stress. This study highlights the valuable application of conservation physiology principles to fisheries management of this endemic and threatened guitarfish species. [ABSTRACT FROM AUTHOR]

Background: Neck pain remains a persistent challenge in modern society and is frequently encountered across a wide range of occupations, particularly those involving repetitive and monotonous tasks. It might be expected that patterns of trapezius muscle activity at work, characterized by few breaks and prolonged periods of sustained muscle activity, are linked to neck pain. However, previous cross-sectional studies have generally failed to establish a definitive association. While some longitudinal studies have suggested that extended periods of heightened muscle activity could be a risk factor for neck pain, these findings often relied on limited participant numbers or specific professional groups. This study aimed to investigate the relationship between trapezius muscle activity and neck pain by pooling data from seven Scandinavian research institutes encompassing a diverse range of occupational backgrounds. Methods: Electromyographic (EMG) data for the upper trapezius muscle, collected during working hours, were coupled with questionnaire responses pertaining to neck pain, individual characteristics, and potential confounding variables for a total of 731 subjects. Additionally, longitudinal data from 258 subjects were available. The various EMG datasets were consolidated into a standardized format, and efforts were made to harmonize inquiries about neck pain. Regression analyses, adjusting for sex and height, were conducted to explore the associations between muscle activity variables and neck pain. An exposure index was devised to quantify the cumulative neck load experienced during working hours and to differentiate between various occupational categories. Results: The cross-sectional data displayed a distinct pattern characterized by positive associations for brief periods of sustained muscle activity (SUMA) and negative associations for prolonged SUMA-periods and neck pain. The longitudinal data exhibited a contrasting trend, although it was not as pronounced as the cross-sectional findings. When employing the exposure index, notable differences in cumulative muscle load emerged among occupational groups, and positive associations with longitudinal neck pain were identified. Discussion: The results suggest that individuals with neck pain experience higher cumulative workloads and extended periods of muscle activity over the long term. In the short term, they appear to compensate by taking frequent short breaks, resulting in a lower cumulative workload. Regardless of their occupation, it is crucial to distribute work breaks throughout the workday to ensure that the cumulative load remains manageable. [ABSTRACT FROM AUTHOR]

The cardiac response to physical exertion is linked to factors such as age, work intensity, and fitness levels. The primary objective of this study was to characterize within-session changes in cardiac response to running in Canadian football athletes, which may indicate physical fatigue. Performance profiles were collected from GPS and heart rate (HR) sensors worn by 30 male Canadian varsity football players (20–26 years old) over 28 games and practices. Running efforts with 60–180 s of rest were detected, and the maximum HR (HRmax) and peak HR recovery (HRRpk) during rest were extracted. Additionally, a new metric of cardiovascular cost (CVC) was developed to reflect the efficiency of the HR response to physical workload. HRmax was higher in games (p < 0.001) and in linemen (p < 0.001), and it increased over time (p < 0.001). HRRpk was higher in skilled players (p < 0.001) and changed over time (p < 0.001) depending on the rest period. CVC was higher in linemen (p < 0.001) and increased over time (p < 0.001). This study demonstrated the utility of HR response metrics to quantify ongoing fatigue experienced by Canadian football athletes and proposed a novel fatigue metric capable of monitoring an athlete's fatigue state in real time. [ABSTRACT FROM AUTHOR]

This study explored the impact of short rest intervals on resisted sprint training in elite youth soccer players, specifically targeting enhanced initial-phase explosive acceleration without altering sprint mechanics. Fifteen U19 soccer players participated in a randomized crossover design trial, executing two sprint conditions: RST2M (6 sprints of 20 m resisted sprints with 2 min rest intervals) and RST40S (6 sprints of 20 m resisted sprints with 40 s rest intervals), both under a load equivalent to 30% of sprint velocity decrement using a resistance device. To gauge neuromuscular fatigue, countermovement jumps were performed before and after each session, and the fatigue index along with sprint decrement percentage were calculated. Interestingly, the results indicated no significant differences in sprint performance or mechanical variables between RST2M and RST40S, suggesting that the duration of rest intervals did not affect the outcomes. Horizontal resistance appeared to mitigate compensatory patterns typically induced by fatigue in short rest periods, maintaining effective joint movement and hip extensor recruitment necessary for producing horizontal ground forces. These findings propose a novel training strategy that could simultaneously enhance sprint mechanics during initial accelerations and repeated sprint abilities for elite youth soccer players—a methodology not previously employed [ABSTRACT FROM AUTHOR]

Brain activity during the resting state is widely used to examine brain organization, cognition and alterations in disease states. While it is known that neuromodulation and the state of alertness impact resting-state activity, neural mechanisms behind such modulation of resting-state activity are unknown. In this work, we used a computational model to demonstrate that change in excitability and recurrent connections, due to cholinergic modulation, impacts resting-state activity. The results of such modulation in the model match closely with experimental work on direct cholinergic modulation of Default Mode Network (DMN) in rodents. We further extended our study to the human connectome derived from diffusion-weighted MRI. In human resting-state simulations, an increase in cholinergic input resulted in a brain-wide reduction of functional connectivity. Furthermore, selective cholinergic modulation of DMN closely captured experimentally observed transitions between the baseline resting state and states with suppressed DMN fluctuations associated with attention to external tasks. Our study thus provides insight into potential neural mechanisms for the effects of cholinergic neuromodulation on resting-state activity and its dynamics. Author summary: Brain activity during the resting period, commonly referred to as resting-state activity, is known to display coherent spontaneous fluctuations, which form various functional networks. Yet, the origin of these low-frequency (less than 0.05 Hz) fluctuations is poorly understood. In this work, we ask why is, in specific brain regions, such slow activity higher during rest periods compared to active periods. We use computational modeling and experimental data to demonstrate that the reduction of cholinergic release results in an increase in resting-state activity and its functional connectivity in a prominent resting state network—the DMN (Default-mode network). Our work supports the hypothesis that cellular intrinsic and synaptic changes mediated by (chemical) neuromodulatory mechanisms contribute to the increases of low-frequency fluctuations during the resting state. [ABSTRACT FROM AUTHOR]

AbstractThe concrete equivalent mortar (CEM) method, mainly used in the laboratory, offers a course that facilitates and accelerates experimental test programs with relatively small amounts of materials. To this end, two CEM mixes, with natural and recycled aggregates, at different superplasticizer (SP) concentrations, were tested. The key objective was to investigate how CEM flow property changed at 0, 30, and 60 min of resting time, emphasizing the material’s structuring and destructuring effects. This study describes the flow behaviour of CEMs applying specific tools. Also, a vane-geometry rheometer was used to obtain rheological flow curves. Whatever the SP content in the structuring state, the results indicated reduced flow properties over time. However, an SP content of 1.3% retard the structural build-up property that was not evident at 60 min-rest time. Spread diameters ranging between 300 and 400 mm are measured with the mini cone immediately after mixing. After 60 min of resting time, these diameters were reduced between 260 and 300 mm. Remixing after prolonged rest periods reduces the flow stress values, which decrease from 10 to 18 Pa to 6 to 14 Pa. After a structural build-up at a rest time, the structural break-down effect by remixing re-fluidifies the mixtures. The fluidity has recovered its initial state, reflecting a thixotropic property. [ABSTRACT FROM AUTHOR]

Aim: Circular training is thought to have a motivating feature by distracting the individual from routine and boring training practices with different exercise methods. In this context, the aim of this study was to investigate the effect of different rest periods applied during circular training on blood lactate levels. Method: The pretest-posttest model was used in the study. The sample of the study consisted of 24 (Xage =20,00±1,79; Xheight =171,75 ± 6,22; Xweight =75,01± 6,39) volunteer male basketball athletes. Lactate measurements were taken before, during and after circular training with different rest periods. The data was analyzed in the SPSS 24.0 package program, with a 95% confidence interval and a 0.05 significance level, and normality analysis was performed with the Shapiro-Wilk test. Since the data were not normally distributed, nonparametric tests were applied. The change in heart rate averages and lactate levels of the research group according to resting times were evaluated by Wilcoxon Test. Results: In general, it was determined that the circular training program with different rest intervals caused significant differences in the measurement parameters (Heart Rate, and Lactate) of the participants (p<0.05). It was observed that the average heart rate and lactate values reached during training decreased as the rest period of the research group increased. On the other hand, the effects of long-term circular training programs with different rest intervals on aerobicanaerobic energy metabolism will contribute to the literature. [ABSTRACT FROM AUTHOR]

Flight crew experience fatigue due to sleep loss, circadian desynchrony, early duty start times, long duty periods, high and low workloads, and unscheduled duties. As fatigue is considered a significant safety risk in the air transport industry, the primary approaches to managing fatigue are mandating prescriptive limits for work and rest periods or adopting performance-based fatigue risk management systems (FRMS). However, recent aviation incidents indicate that current regulations may not be adequate to manage the fatigue risk experienced by the flight crew. This study evaluates Australian flight crew fatigue management regulations using a new fatigue regulation evaluation framework (FREF) adapted from Jones et al. (2005). Results show that Australian regulations for flight crew include limits on flight duty period (FDP), off duty period, FDP start time, sleep requirements for flight crew before starting an FDP, high and low workloads, circadian rhythm disruptions, and fatigue awareness. However, there are regulation variations in addressing lengths of sectors and methods to report fatigue, which may need to be reviewed to manage fatigue better. Recommendations are made to consider incorporating these factors into fatigue regulations to ensure a safe air transport system. • Fatigue is considered a significant safety risk in air transport. • Factors related to fatigue require to be adequately addressed in the regulations. • There are variations in addressing these flight crew fatigue related factors. • Adequately addressing the flight crew fatigue related factors in the regulations can assist to manage fatigue [ABSTRACT FROM AUTHOR]