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1. Posters display III clinical outcome and PET

Author

Baliño, N. Nestor Perez, Masoli, O., Traverso, S., Grynberg, L., Rappallo, C., Redruello, M., Rosa, D., Cragnolino, D., Meretta, A., Vidal, L., Graf, S., Khorsand, A. Aliasghar, Gyongyosi, M., Karanikas, G., Eidherr, H., Kletter, K., Porenta, G., Glogar, D., Sochor, H., Beheshti, M., Poetzi, C., Wadsak, W., Porenta, G., Maurer, G., Wolfram, J., Winter, O. Olivier De, Velghe, A., Veire, N. Van de, Bondt, P. De, Buyzere, M. De, Wiele, C. Van de, Backer, G. De, Gillebert, T. C., Dierckx, R. A., Sutter, J. De, Bernard, D., Langlois, M., Duarte, P. S. Paulo, Mastrocolla, L. E., Sampaio, C. R. E., Rossi, J. M., Smanio, P. E., Lima, E. V., Oliveira, C. A. R., Pereira, J. C. R., Smanio, P. Paola, Beraldo, P., Rodrigues, F., Thom, A., Yoshinaga, K. Keiichiro, Ukkonen, H., Burwash, I., DeKemp, R., Dafoe, W., Davies, R., Haddad, H., Ruddy, T., DaSilva, J., Beanlands, R., Chow, B., Williams, K., Garrard, L., Szeto, A., Aung, M., Sondergaard, H. Hanne, Bottcher, M., Madsen, M. M., Schmitz, O., Nielsen, T. T., Botker, H. E., Høilund-Carlsen, P. F. Poul F., Johansen, A., Christensen, H. W., Vach, W., Møldrup, M., Haghfelt, T., Johansen, A. Allan, Høilund-Carlsen, P. F., Christensen, H. W., Møldrup, M., Kristensen, J. Jens Hedega, Maeng, M., Mortensen, U. M., Berg, J. S., Rehling, M., Nielsen, T. T., Elsaban, K. Khaled, El-Kady, T., El-Gabaly, M., Yehia, A., El-Sayed, M., Naum, A. Alexandru, Laaksonen, M. S., Tuunanen, H., Oikonen, V., Kemppainen, J., Järvisalo, M. J., Nuutila, P., Knuuti, J., Vanzetto, G. Gerald, Jacon, P., Fagret, D., Machecourt, J., Lindner, O. Oliver, Vogt, J., Kammeier, A., Fricke, E., Wielepp, P., Baller, D., Lamp, B., Holzinger, J., Horstkotte, D., Burchert, W., Nekolla, S. G. Stephan, Souvatzoglou, M., Hausleiter, J., Henke, N., Kruschke, K., Bengel, F., Schwaiger, M., Sundaram, P. S. Palaniswamy Shanmuga, Padma, S., Haridas, K. K., Kumar, S., Zachariah, M., Livschitz, S. Shay, Zornitzki, T., Vered, S., Oettinger, M., Levy, R., Caspi, A., Faraggi, D., Knobler, H., Mats, I., Solodky, A., Ben-Gal, T., Battler, A., Zafrir, N. Nili, Varani, E. Elisabetta, Balducelli, M., Severi, S., Patroncini, A. L., Vecchi, G., Gatti, C., Corbelli, C., Casanova, R., Maresta, A., Cittanti, C. Corrado, Valgimigli, M., Giganti, M., Malagutti, P., Percoco, G., Bagatin, E., Panareo, S., Avigni, N., Ferrari, R., Feggi, L., Filardi, P. Pasquale Perrone, Cuocolo, A., Storto, G., Brevetti, G., Dellegrottaglie, S., Corrado, L., Cafiero, M., Polimeno, M., Zarrilli, A., Chiariello, M., Marcassa, C. Claudio, Campini, R., Calza, P., Giannuzzi, P., Galassi, A. R. Alfredo, Grasso, C., Azzarelli, S., Leotta, E., Moshiri, S., Tamburino, C., Acampa, W., Ferro, A., Petretta, M., Salvatore, M., Cuocolo, A. Alberto, Pieri, P. L. Pierluigi, Berta, R., Moscatelli, G., Buccoliero, F., Inglese, E., Marcassa, C. Claudio, Medolago, G., Imperiale, A., Rimini, M. L. De, Bertagna, F., Sullo, P., Lupo, M., Cappagli, M., Fukuda, H. Hiroshi, Kunimasa, T., Furuhashi, T., Moroi, M., Yasuhi, W. Watanabe, Akihiro, S., Akio, Y., Ryou, K., Kimio, T., Yasunori, W., Yasuhiko, T., Nariaki, E., Watabe, H. Hiroshi, Teramoto, N., Ohta, Y., Kou, Y., Hayashi, T., Iida, H., Bom, H. S. Hee-Seung, Song, H. C., Min, J. J., Heo, Y. J., Seo, J. H., Lee, J. Jae-Tae, Bae, J. H., Jeong, S. Y., Ahn, B. C., Chae, S. C., Lee, K. B., Popiel, M. Malgorzata, Grajek, S., Czepczynski, R., Breborowicz, P., Lesiak, M., Czyz, A., Sawinski, K., Komarnicki, M., Cieslinski, A., Sowinski, J., Ferreira, A. António, Ventosa, A., Gil, V., Calqueiro, J., Lima, S., Aguiar, C., Couto, R., Raposo, L., Seabra-Gomes, R., Vasconcelos, M. Mariana, Martins, E., Faria, T., Oliveira, A., Garcia, M., Pereira, J., Rocha-Gonçalves, F., Lourenço, C. Cândida, Roque, C., Ferrer-Antunes, A., Ferreira, M., Providência, L. A., Lima, J., Medrea, C. Claudia, Bogdan, R., Lazar, A., Mot, S., Capilneanu, R., Kozulin, V. Vickenty, Berkovich, O., Ivashchenko, T., Larionova, V., Esipovich, I., Gordeev, M., Panov, A., Shlyakhto, E., Burova, N., Baranov, D., Timoshin, V., Chuprova, S., Shkolnikova, M., Zaklyazminskaya, E., Poliakov, A., Sazonova, S. Svetlana, Romero-Farina, G., Arenillas, J. F., Candell-Riera, J., Aguadè-Bruix, S. Santiago, Leon, G. De, Molina, C. A., Chacon, P., Montaner, J., Rovira, A., Alvarez-Sabin, J., Namdar, M. Mehdi, Siegrist, P. T., Grathwohl, R., Delaloye, R., Koepfli, P., Wyss, C. A., Kaufmann, P. A., Bartenstein, N., Hellermann, J., Siegrist, P. T. Patrick, Namdar, M., Pollack, C., Schurr, U., Kaufmann, P. A., Zellweger, M. J. Michael, Burger, P. C., Mueller-Brand, J., Pfisterer, M. E., Gordon, L. Leonie, Epps, A., Chiarameda, S., Navare, S. Sachin, Ahlberg, A., Cyr, G., Katten, D., Ausef, A., Heller, G., Darrow, B. Bruce, Thomas, G. S. Gregory, Ip, T. K., Thompson, R. C., Kramer, D. B., Rice, D. L., Thomas, J. J., Miyamoto, M. I., Druz, R. S. Regina, Nichols, K. J., Akinboboye, O. O., Reichek, N., Podrasky, E. Ernest, Tuttle, R. T. Robert, Shaw, L. S. Linda, Hanson, M. W. H. Michael, Borges-Neto, S. Salvador, Lundbye, J. Justin, Werden, S., Kazi, F., Whalen, A., Noble, G. L., O’Sullivan, D., Boden, W. E., Heller, G. V., Ausef, A. Amir, Ahlberg, A. W., Danias, P. G., Papaioannou, G. I., Leka, I. A., Boden, W. E., Heller, G. V., Beretta, M. Mario, Viňas, S., Gonzalez, A., Vidal, I., and Rener, A.

Published
2005
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13. Posters display III clinical outcome and PET

Author

Baliño, N., Masoli, O., Traverso, S., Grynberg, L., Rappallo, C., Redruello, M., Rosa, D., Cragnolino, D., Meretta, A., Vidal, L., Graf, S., Khorsand, A., Gyongyosi, M., Karanikas, G., Eidherr, H., Kletter, K., Porenta, G., Glogar, D., Sochor, H., Beheshti, M., Poetzi, C., Wadsak, W., Maurer, G., Wolfram, J., Winter, O., Velghe, A., Veire, N., Bondt, P., Buyzere, M., Wiele, C., Backer, G., Gillebert, T., Dierckx, R., Sutter, J., Bernard, D., Langlois, M., Duarte, P., Mastrocolla, L., Sampaio, C., Rossi, J., Smanio, P., Lima, E., Oliveira, C., Pereira, J., Beraldo, P., Rodrigues, F., Thom, A., Yoshinaga, K., Ukkonen, H., Burwash, I., DeKemp, R., Dafoe, W., Davies, R., Haddad, H., Ruddy, T., DaSilva, J., Beanlands, R., Chow, B., Williams, K., Garrard, L., Szeto, A., Aung, M., Sondergaard, H., Bottcher, M., Madsen, M., Schmitz, O., Nielsen, T., Botker, H., Høilund-Carlsen, P., Johansen, A., Christensen, H., Vach, W., Møldrup, M., Haghfelt, T., Kristensen, J., Maeng, M., Mortensen, U., Berg, J., Rehling, M., Elsaban, K., El-Kady, T., El-Gabaly, M., Yehia, A., El-Sayed, M., Naum, A., Laaksonen, M., Tuunanen, H., Oikonen, V., Kemppainen, J., Järvisalo, M., Nuutila, P., Knuuti, J., Vanzetto, G., Jacon, P., Fagret, D., Machecourt, J., Lindner, O., Vogt, J., Kammeier, A., Fricke, E., Wielepp, P., Baller, D., Lamp, B., Holzinger, J., Horstkotte, D., Burchert, W., Nekolla, S., Souvatzoglou, M., Hausleiter, J., Henke, N., Kruschke, K., Bengel, F., Schwaiger, M., Sundaram, P., Padma, S., Haridas, K., Kumar, S., Zachariah, M., Livschitz, S., Zornitzki, T., Vered, S., Oettinger, M., Levy, R., Caspi, A., Faraggi, D., Knobler, H., Mats, I., Solodky, A., Ben-Gal, T., Battler, A., Zafrir, N., Varani, E., Balducelli, M., Severi, S., Patroncini, A., Vecchi, G., Gatti, C., Corbelli, C., Casanova, R., Maresta, A., Cittanti, C., Valgimigli, M., Giganti, M., Malagutti, P., Percoco, G., Bagatin, E., Panareo, S., Avigni, N., Ferrari, R., Feggi, L., Filardi, P., Cuocolo, A., Storto, G., Brevetti, G., Dellegrottaglie, S., Corrado, L., Cafiero, M., Polimeno, M., Zarrilli, A., Chiariello, M., Marcassa, C., Campini, R., Calza, P., Giannuzzi, P., Galassi, A., Grasso, C., Azzarelli, S., Leotta, E., Moshiri, S., Tamburino, C., Acampa, W., Ferro, A., Petretta, M., Salvatore, M., Pieri, P., Berta, R., Moscatelli, G., Buccoliero, F., Inglese, E., Medolago, G., Imperiale, A., Rimini, M., Bertagna, F., Sullo, P., Lupo, M., Cappagli, M., Fukuda, H., Kunimasa, T., Furuhashi, T., Moroi, M., Yasuhi, W., Akihiro, S., Akio, Y., Ryou, K., Kimio, T., Yasunori, W., Yasuhiko, T., Nariaki, E., Watabe, H., Teramoto, N., Ohta, Y., Kou, Y., Hayashi, T., Iida, H., Bom, H., Song, H., Min, J., Heo, Y., Seo, J., Lee, J., Bae, J., Jeong, S., Ahn, B., Chae, S., Lee, K., Popiel, M., Grajek, S., Czepczynski, R., Breborowicz, P., Lesiak, M., Czyz, A., Sawinski, K., Komarnicki, M., Cieslinski, A., Sowinski, J., Ferreira, A., Ventosa, A., Gil, V., Calqueiro, J., Lima, S., Aguiar, C., Couto, R., Raposo, L., Seabra-Gomes, R., Vasconcelos, M., Martins, E., Faria, T., Oliveira, A., Garcia, M., Rocha-Gonçalves, F., Lourenço, C., Roque, C., Ferrer-Antunes, A., Ferreira, M., Providência, L., Lima, J., Medrea, C., Bogdan, R., Lazar, A., Mot, S., Capilneanu, R., Kozulin, V., Berkovich, O., Ivashchenko, T., Larionova, V., Esipovich, I., Gordeev, M., Panov, A., Shlyakhto, E., Burova, N., Baranov, D., Timoshin, V., Chuprova, S., Shkolnikova, M., Zaklyazminskaya, E., Poliakov, A., Sazonova, S., Romero-Farina, G., Arenillas, J., Candell-Riera, J., Aguadè-Bruix, S., Leon, G., Molina, C., Chacon, P., Montaner, J., Rovira, A., Alvarez-Sabin, J., Namdar, M., Siegrist, P., Grathwohl, R., Delaloye, R., Koepfli, P., Wyss, C., Kaufmann, P., Bartenstein, N., Hellermann, J., Pollack, C., Schurr, U., Zellweger, M., Burger, P., Mueller-Brand, J., Pfisterer, M., Gordon, L., Epps, A., Chiarameda, S., Navare, S., Ahlberg, A., Cyr, G., Katten, D., Ausef, A., Heller, G., Darrow, B., Thomas, G., Ip, T., Thompson, R., Kramer, D., Rice, D., Thomas, J., Miyamoto, M., Druz, R., Nichols, K., Akinboboye, O., Reichek, N., Podrasky, E., Tuttle, R., Shaw, L., Hanson, M., Borges-Neto, S., Lundbye, J., Werden, S., Kazi, F., Whalen, A., Noble, G., O'Sullivan, D., Boden, W., Danias, P., Papaioannou, G., Leka, I., Beretta, M., Viňas, S., Gonzalez, A., Vidal, I., and Rener, A.

Published
2018

22. Automated CT volumetry of pulmonary metastases: evaluation of varied volume change thresholds for response assessment

Author

Marten, K, Rummeny, E J, Engelke, C, MacManus, M P, Alam, N, Hicks, R J, Ball, D L, Cronin, P, Dwamena, B, Kelly, A, Carlos, R, Rasmussen, K, Madsen, H T, Rasmussen, F, Rasmussen, T R, Baandrup, U, Pilegaard, H K, Pedersen, U, Palshof, T, Rehling, M, Vilarino-Varela, M J, Taylor, A, Rockall, A G, Reznek, R H, Powell, M E B, Anstee, A, Scott, F, Culver, L, Rustin, G, Padwick, M, Padhani, A R, Bhatia, K, Sahdev, A, Hogarth, K, Chew, S, Grossman, A, O’Regan, K, Hodnett, P, Corrigan, M, Redmond, H, Barry, J, Sandomenico, F, Catalano, O, Fazioli, F, Mattace Raso, M, De Chiara, A, Apice, G, Petrillo, A, De Lutio di Castelguidone, E, and Siani, A

Subjects
Workshops, Article
Abstract

Aim To evaluate volume change thresholds for reliable volumetric evaluation of pulmonary metastatic tumour response in comparison with the response evaluation criteria of solid tumours (RECIST). Methods Fifty consecutive patients with pulmonary metastases undergoing follow-up chest multidetector-row CT under chemotherapy were prospectively included. Metastatic volumes were estimated twice by two independent observers using commercially available automated volumetry software. Intra- and interobserver agreements of metastatic volume change were estimated by 95% limits of agreement. The response to chemotherapy, as defined by an incrementally increasing percentual metastatic volume change (20%–70%), was assessed by extended Kappa statistics. Categorical agreement was correlated with percentual volume change thresholds as defined for pulmonary tumour response. Results A total of 202 metastases were evaluated. The 95% intra- and interobserver limits of agreement were −2.16%–1.88% and −1.79%–2.14%, respectively. Partial response, total remission or progressive disease were present in 46% of patients using a 70% volume change threshold and in 48%, 56%, 62%, 70% and 82% of patients using 60%, 50%, 40%, 30% and 20% thresholds, respectively. Discordant response ratings occurred in 0%–6% of patients. General combined categorical agreement on treatment response was very good (κ=0.94–1), but was diminished with volume thresholds 0.05). Kappa values correlated in linear fashion with the threshold values (r2=0.868; p, Aim Relapse after chemoradiation for non-small cell lung cancer (NSCLC) carries a dismal prognosis. A prospective positron emission tomography (PET)-response database was used to estimate how many patients could benefit from response-adapted surgery. Method Pre- and post-treatment fluorodeoxyglucose (FDG)-PET scans were performed for 88 patients who received 60 Gy with concurrent platinum-based chemotherapy (n=73) or 60 Gy alone (n=15). Response categories were complete metabolic response (CMR), partial metabolic response (PMR), stable metabolic disease (SMD), or progressive metabolic disease (PMD). We considered that medically operable patients who attained a PMR with potentially resectable residual disease confined to the lung and patients who attained a CMR but subsequently relapsed locally with anatomically resectable disease could benefit from surgery. Twenty-four medically inoperable patients could not have tolerated thoracotomy, (predominantly chronic obstructive airways disease, but also heart disease (n=6), rheumatoid arthritis (n=1), and renal failure (n=1)). Of the remaining 64 patients, 29 attained CMR (45%), 25 PMR (39%), 4 SMD (6%) and 6 PMD (9%). Of 29 CMR patients, 5 ultimately had local relapses that could potentially have been prevented by surgery, 15 never relapsed and 9 relapsed with extensive disease. Of 26 PMR patients, 12 might have benefited from salvage surgery as they had absent (n=10) or minimal (2) evidence of mediastinal disease and potentially resectable residual parenchymal disease. Of 64 patients, potentially fit for thoracotomy, 17 might have benefited from salvage or adjuvant surgery after chemoradiation. To benefit 5 CMR patients, surgery would have been necessary in 29, including 15 who may have already been cured. PMR patients represent the best candidates for response-adapted salvage surgery., Aim To estimate the diagnostic accuracy of dynamic contrast enhanced (DCE) computed tomography (CT) and magnetic resonance (MR) imaging, and [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) and Tc-99m depretiode single photon emission computed tomography (SPECT) imaging for the evaluation of solitary pulmonary nodules using a meta-analysis. Data sources Studies published between January 1990 and December 2005 in PubMed. Study selection Studies that examined (DCE) CT and MR imaging patterns and MR imaging signal characteristics, and studies that examined [18F]FDG PET, Tc-99m depretiode SPECT imaging for the evaluation of solitary pulmonary nodules and; enrolled at least 10 participants with a pulmonary nodule, with histological confirmation of the majority of lesions; and presented sufficient data to permit calculation of contingency tables were included in the analysis. Data extraction Two reviewers independently abstracted data regarding true positive, false positive, false negative and true negative of the imaging test, and independently assessed study quality and disagreements were resolved by a third reviewer. Data synthesis Forty-five studies met the inclusion criteria in total, 10 DCE CT studies, 6 DCE MRI studies, 22 [18F]FDG PET studies, and 7 99mTc-depreotide SPECT studies. Study methodological quality was fair. Sample sizes were small, minimum 20, maximum 356 and mean 65 subjects. We used a meta-analytic method to construct summary receiver-operating characteristic curves. These showed no statistically significant difference between the modalities although DCE CT performed slightly less well. Conclusions Dynamic contrast-enhanced CT and MR imaging and FGD PET and 99mTc-depreotide SPECT imaging are accurate non-invasive imaging tests for distinguishing malignant from benign solitary pulmonary nodules or mass lesions., Aim To assess, separately and in combination, the diagnostic impact of high resolution computed tomography (HRCT) and 99mTc-depreotide (a somatostatin receptor scintigraphy), in patients with pulmonary lesions verified by CT. Methods We included 127 patients presenting with one or more pulmonary lesions suspected of malignancy on CT. Supplementary HRCT and 99mTc-depreotide tomography were performed. HRCT findings were classified into three groups: high, intermediate and low probability of malignancy. The final diagnosis was based on cytology, histology or CT follow-up. Results Sixty-one out of 127 patients had lung cancer. The overall sensitivity, specificity and accuracy of 99mTc-depreotide were 95%, 58%, and 76%, respectively. The sensitivity of 99mTc-depreotide in tumours >15 mm was 100%; the three false negatives were tumours ≤15 mm. HRCT showed high probability of malignancy in 58 patients; 48 had lung cancer. Twenty patients were classified as low probability, one was false negative. The intermediate group consisted of 49 patients (39%); 12 had lung cancer. When adding the intermediate group to the high probability group sensitivity, specificity and accuracy of HRCT were 98%, 29%, and 62%, respectively. Of the 49 patients in the intermediate group 99mTc-depreotide was positive in 23 patients (nine true positive) and negative in 26 (three false negative). Conclusion The sensitivity of 99mTc-depreotide alone was high in patients with lung lesions >15 mm. HRCT alone was accurate in the group of patients with high and low probability of malignancy. However, HRCT was indeterminate in 39% of the patients. In this group additional 99mTc-depreotide contributed to further diagnostic strategy., Aim Accurate target volume delineation is essential for effective radiotherapy. Pelvic lymph nodes are not easily identifiable on conventional imaging, but can be visualised by contrast-enhanced magnetic resonance imaging (MRI) using intravenous ultra-small particles of iron-oxide (USPIO). We have previously reported pelvic node clinical target volume (CTV) delineation guidelines for use with conventional imaging, based on nodal mapping studies using USPIO. The aim of this study was to independently verify these guidelines in a further cohort of patients. Methods Ten patients with gynaecological malignancy underwent MRI with and without intravenous USPIO. MR sequences were transferred to a radiotherapy 3D planning system. The proposed guidelines were used to outline a pelvic node CTV on pre-contrast T2-weighted images. On post-contrast T2 *-weighted images the pelvic nodes were identified and outlined. The pre- and post-contrast images were co-registered and CTV examined for node coverage. Results By applying the guidelines, full coverage of 737 node outlines out of a total of 741 was achieved. Of the 4 outlines not fully covered, 2 were in the anterior external iliac and 2 in the lateral external iliac node regions. Conclusion MRI using USPIO has enabled the production of guidelines for localising a pelvic node CTV with conventional imaging. Application of these guidelines to a further cohort of patients resulted in coverage of 99.5% of node outlines demonstrating the reliability of this technique., Aim To record water diffusion coefficients of normal uterine structures and to correlate water diffusion with tumour grade and stage of endometrial cancer. Methods Seventeen women with endometrial cancer (85% undergoing hysterectomy) were evaluated at 1.5 and 3 T using multiplanar T2-weighted, dynamic T1-weighted contrast enhanced and single shot echo-planar imaging (EPI) diffusion-weighted magnetic resonance imaging (MRI) (b=0, 50, 150, 500, 1000 s /mm 2) for staging purposes. Apparent diffusion coefficients (ADC) (from all b-values) of imaging determined and histologically confirmed normal myometrium, cervix stroma and cervical mucosa were obtained. Tumour ADCs were correlated with histological grade and pathological stage. Results An overlap in ADC values between cervical mucosa (median = 1.33 × 10 −3 mm 2/s; inter-quartile range = 0.95–1.52 × 10 −3 mm 2/s) and myometrium (median = 1.25 × 10 −3 mm 2/s; inter-quartile range = 0.97–1.41 × 10 −3 mm 2/s) was observed but both were greater than cervix stroma (median = 0.62 × 10 −3 mm 2/s; inter-quartile range = 0.23–0.82 × 10 −3 mm 2/s) (Mann–Whitney test; p=0.002). Fifteen tumours, 13 endometrioid carcinomas (grade 1=6; grade 2=3; grade 3=6), 1 clear cell (grade = 3) and 1 mullerian tumour (grade = 3) were found at pathology. The pathological tumour stages for the 17 tumours were T0 = 1, T1a/b = 2, T1c = 8, T2 = 3, T3 = 3. There was a significant difference between the ADC values of tumours (median = 0.73 × 10 −3 mm 2/s; interquartile range = 0.66–0.78 × 10 −3 mm 2/s) and myometrium (p=0.001) with greater restriction in tumours. There was a negative Kendall’s rank correlation between adenocarcinoma ADC and histological grade (τ=−0.52, p=0.018) and pathological stage (τ=−0.60, and p=0.006); that is aggressive lesions had lower ADC values. Conclusion Intrinsic differences in water diffusion profile between normal myometrium and tumour enable tumour detection on MRI and also reflect aggressiveness of histological lesion., Aim To evaluate and compare the performance of [123I]meta-iodobenzylguanidine (MIBG) with cross sectional imaging in the detection and localisation of adrenal and extra-adrenal phaeochromocytomas. Methods All patients between 1993 and 2005 with adrenal or extra-adrenal phaeochromocytomas that had computed tomography (CT) and magnetic resonance (MR) imaging were identified. Patients included in the study had biochemical or clinical evidence of a phaeochromocytoma or were part of a paraganglioma syndrome. Imaging features on CT and MRI including tumour location, size, and CT contrast enhancement, MRI signal characteristics and MIBG positivity were compared. In particular tumours not detected on MIBG were closely interrogated. Results We identified 65 patients with 72 adrenal phaeochromocytomas, 1 of which had metastases at presentation. 60 of these had [123I]MIBG (9 negative/51 positive). We identified 38 patients with extra-adrenal tumours (18 neck, 2 chest, 17 abdomen, 4 pelvis, 2 spine) including 7 with disseminated metastases and either resected primary or unknown primary at presentation. Thirty-three of these had MIBG studies (12 negative/21 positive). The sensitivity of MIBG when compared against CT and MRI was 85% and 63% for adrenal and extra-adrenal tumours respectively. The radiological features of phaeochromocytomas in patients with MIBG-negative studies are emphasised. Conclusion MIBG is more sensitive in detecting phaeochromocytomas at adrenal compared to extra-adrenal locations. MIBG is more likely to be negative in adrenal tumours with only a thin rim of peripheral viable tissue and central necrosis. No specific feature predicts negativity for extra-adrenal sites., Aim Malignant melanoma is the commonest cause of skin-cancer related deaths worldwide. Nodular melanoma is an aggressive type of melanoma due to its vertical growth and tendency to metastasise. Its incidence may also be increasing. The aims of this study were to review a cohort of patients with histologically proven nodular melanoma to determine if the incidence is increasing. We also investigated the incidence and distribution of metastatic spread of nodular melanoma based on follow-up computed tomography (CT) imaging. Methods A retrospective review was performed using a local database of melanoma patients in a tertiary referral centre. Radiological investigations were reviewed and evidence of the development of visceral, skeletal or soft tissue metastases based on follow up CT imaging was recorded. Results A total of 269 patients with malignant melanoma were identified. Histological analysis was available in 144 of these patients. Nodular melanoma accounted for 46% (n=66) of these patients. Metastatic disease was identified in 15% (n=10) of patients with nodular melanoma, either at presentation or on follow-up CT examination. The commonest sites of metastatic spread included lung (50%), liver (30%), spleen (20%), skin (20%) and peritoneum (20%). Sentinel lymph node mapping was negative in 50% (n=5) of patients who subsequently developed distant metastases. Conclusion Nodular melanoma is an aggressive condition and may be increasing in incidence with 46% prevalence in our study. Sentinel node status is not a reliable predictor of disease progression in patients with nodular melanoma. Nodular melanoma metastasised to distant sites more often than other histological subtypes in our study and therefore close follow-up of these patients is recommended., Aim To discuss the role of contrast-enhanced ultrasonography (CEUS) in the evaluation of soft-tissue tumors and to correlate these results with those from computed tomography (CT) and magnetic resonance imaging (MRI). Methods Twenty-seven patients with soft tissue tumors evaluated with SonoVue contrast agent (Bracco, Italy) and Technos software (Esaote, Italy) were reviewed. Cases included: malignant fibrous histiocytoma (2), myxoid liposarcoma (2), well-differentiated liposarcoma of the salivary gland (1), recurring fibrosarcoma (2), Merckel tumour (1), breast MALToma (1), low-grade sarcoma (1), hepatocellular carcinoma (HCC) subcutaneous seeding (2), soft-tissue metastasis (5), benign nerve sheath tumor (2), post-traumatic neuroma (2), lipoma (3), intramuscular haemangioma (1), elastofibroma dorsi (2). We subjectively evaluated intralesional microcirculation and macrocirculation, intensity and distribution of contrast enhancement and identified five patterns: (1) absence of enhancement; (2) slight enhancement; (3) diffuse macrocirculation with slow wash-out; (4) macrocirculation and microcirculation with fast enhancement and quick wash-out; (5) diffuse, intense, and heterogeneous enhancement with macrocirculation and persistent microcirculation. Ten of these patients were examined with contrast enhanced CT, 17 patients with MRI. Results Pattern 1 was found in lipomas, pattern 2 in elastofibroma dorsi and post-traumatic neuroma, pattern 3 in haemangioma and neurinomas, pattern 4 in fibrosarcoma, Merckel tumor, well-differentiated sarcoma and seeding HCCs; pattern 5 in malignant fibrous histiocytomas, myxoid liposarcomas, and subcutaneous metastasis. Only in the well-differentiated liposarcoma of the salivary gland, did CEUS demonstrate a pattern 1 with erroneous diagnosis of lipoma. In all other lesions there was good correlation with CT, MRI, and histological exams. Conclusion CEUS is a non-invasive diagnostic method in the initial work-up of soft-tissue tumors. The description of vascular patterns can be important for diagnosis and differentiation of benign from malignant tumours.

Published
2006

35. 99mTc-Sestamibi SPECT is a useful technique for viability detection

Author

Kaltoft, A., Bøttcher, M., Rønnow Sand, N. P., Flø, C., Toftegaard, T., Nielsen, T., and Rehling, M.

Subjects
Viability, NH/FDG PET, Ischemic cardiomyopathy, 99Tc-Sestamibi-SPECT
Abstract

Objective - Assessment of myocardial viability by 99mTc-Sestamibi Single Photon Emission Computerized Tomography (SPECT) has been suggested as a more readily available and cheaper alternative to Positron Emission Tomography (PET) with 13N-ammonia (NH3) and 18F-fluoro-deoxy-glucose (FDG). We hypothesized that a semi-quantitative evaluation by SPECT could delineate myocardial viability with an acceptable concordance to PET. Design - Fifty patients (age 57 ± 7 years; ejection fraction 28 ± 8%), with ischemic cardiomyopathy, underwent SPECT and PET imaging in random order. Viability by SPECT was defined as a defect size 2 and FDG score ≤2 (five-point scale, 0 = normal, 4 = absent activity). Results - By segmental comparison to PET, SPECT yielded a sensitivity and specificity of 87% and 82% for detection of viable myocardium. The positive and negative predictive values were 96% and 58%, respectively. Conclusion - In patients with severe ischemic cardiomyopathy 99mTc-Sestamibi SPECT can delineate viable myocardium with an acceptable segmental concordance to NH3/FDG PET.

Published
2001
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40. Clearance and renal extraction of technetium-99m-L,L-ethylenedicysteine, I-131-ortho-iodohippurate and I-125-iothalamate in pigs

Author

Nielsen, Søren Steen, Poulsen, E U, Marqversen, J, Nielsen, Lene Elsebeth, Bacher, T, and Rehling, M

Subjects
Erythrocytes, Metabolic Clearance Rate, Swine, Contrast Media, Organotechnetium Compounds, Kidney, Iothalamic Acid, Iodine Radioisotopes, Liver, Linear Models, Animals, Bile, Female, Iodohippuric Acid, Cysteine, Radiopharmaceuticals, Chromatography, High Pressure Liquid
Abstract

99mTc-L,L-ethylenedicysteine (99mTc-EC) has been proposed as a 99mTc-labelled alternative to radio-iodinated ortho-iodohippurate (OIH) for renal imaging and evaluation of renal function. The kinetics of this new renal function agent were studied by a single-injection plasma clearance technique in pigs. 99mTc-EC, 131I-OIH and 125I-iothalamate were injected and the plasma concentration of the three tracers was followed for 240 min. Renal, hepatic and total plasma clearance were calculated. There was no difference between the renal plasma clearance of 99mTc-EC and 131I-OIH (175 +/- 9 versus 178 +/- 8 ml min-1, P = 0.43), whereas the difference between the total plasma clearance of 99mTc-EC and 131I-OIH was highly significant (268 +/- 16 versus 185 +/- 9 ml min-1, P = 0.0001). 99mTc-EC had a significant hepatic clearance of 83 +/- 10 ml min-1 whereas the hepatic clearance of 131I-OIH was negligible. Renal plasma extraction of both 99mTc-EC and 131I-OIH decreased significantly between 2 and 240 min post-injection from 0.85 to 0.45% for 99mTc-EC and from 0.93 to 0.57% for 131I-OIH. Red blood cell binding of 99mTc-EC and 131I-OIH was 6.1% and 20%, respectively. The protein binding of 99mTc-EC and 131I-OIH was 32% for both tracers. We conclude that 99mTc-EC is not a suitable tracer for measuring renal function by the single-injection plasma clearance technique in pigs. This is due to a decreasing renal extraction and a significant hepatic clearance.

Published
1999

41. Clinical assessment of excretory renal function

Author

Petersen, L.J., Birn, H., Ladefoged, S.A., Randers, E., Rehling, M., Reinholdt, B., Rossing, P., Petersen, L.J., Birn, H., Ladefoged, S.A., Randers, E., Rehling, M., Reinholdt, B., and Rossing, P.

Abstract

Udgivelsesdato: 2009/3/23

Published
2009

44. Renal physiology

Author

Amel, S., primary, Crambert, G., additional, Alain, D., additional, Soleimani, M., additional, Amlal, H., additional, Barone, S., additional, Xu, J., additional, Zahedi, K., additional, Walter, Z., additional, Jankowski, V., additional, Joachim, J., additional, Weyer, K., additional, Nielsen, R., additional, Christensen, E., additional, Rehling, M., additional, Birn, H., additional, Dimuccio, V., additional, Ranghino, A., additional, Camussi, G., additional, and Bussolati, B., additional

Published
2012
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45. Renal and extrarenal clearance of 99mTc-MAG3: a comparison with 125I-OIH and 51Cr-EDTA in patients representing all levels of glomerular filtration rate

Author

Rehling, M., Nielsen, B.V., Pedersen, Erling Bjerregaard, Nielsen, L.E., Hansen, H.E., and Bacher, T.

Subjects
Adult, Iodine Radioisotopes, Male, Humans, Female, Iodohippuric Acid, Middle Aged, Kidney, Chromium Radioisotopes, Edetic Acid, Aged, Glomerular Filtration Rate, Technetium Tc 99m Mertiatide
Abstract

This investigation was undertaken in order to determine whether the clearance of technetium-99m mercaptoacetyltriglycine (99mTc-MAG3) is more closely correlated to the clearance of iodine-125 orthoiodohippurate (125I-OIH) than to the clearance of chromium-51 ethylene diamine tetra-acetate (51Cr-EDTA) and whether there is a clinically significant extrarenal clearance of 99mTc-MAG3 . Fifty-one patients with a glomerular filtration rate (GFR) of 4-132ml/min were studied. After a simultaneous single injection of the three tracers, plasma clearance was measured from blood samples 0-5h post injection (p.i.) (0-24h in patients with GFR

Published
1995

46. Cost-effectiveness of remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction

Author

Sloth, Astrid D, Schmidt, Michael R, Munk, Kim, Schmidt, Morten, Pedersen, Lars, Sørensen, Henrik T, Enemark, Ulrika, Parner, Erik T, Bøtker, Hans Erik, Bøttcher, M, Kaltoft, AK, Terkelsen, CJ, Andersen, NH, Hansen, TM, Trautner, S, Lassen, JF, Christiansen, EH, Krusell, LR, Kristensen, SD, Thuesen, L, Nielsen, SS, Rehling, M, and Nielsen, TT

Abstract

Aims: Remote ischaemic conditioning seems to improve long-term clinical outcomes in patients undergoing primary percutaneous coronary intervention. Remote ischaemic conditioning can be applied with cycles of alternating inflation and deflation of a blood-pressure cuff. We evaluated the cost-effectiveness of remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction from the perspective of the Danish healthcare system.Methods and results: Between February 2007 and November 2008, 251 patients with ST-elevation myocardial infarction were randomly assigned to remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention (n=126) or to primary percutaneous coronary intervention alone (n=125). During a 4-year follow-up period, we used data from Danish medical registries and medical records to estimate within-trial cardiovascular medical care costs and major adverse cardiac and cerebrovascular event-free survival. After 4 years of follow-up, mean cumulative cardiovascular medical care costs were €2763 (95% confidence interval 207–5318, P=0.034) lower in the remote ischaemic conditioning group than in the control group (€12,065 vs. €14,828), while mean major adverse cardiac and cerebrovascular event-free survival time was 0.30 years (95% confidence interval 0.03–0.57, P=0.032) higher in the remote ischaemic conditioning group than in the control group (3.51 vs. 3.21 years). In the cost-effectiveness plane, remote ischaemic conditioning therapy was economically dominant (less costly and more effective) in 97.26% of 10,000 bootstrap replications.Conclusion: Remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention appears to be a cost-effective treatment strategy in patients with ST-elevation myocardial infarction.

Published
2017
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47. Abstracts

Author

Dunet, V., primary, Dabiri, A., additional, Allenbach, G., additional, Goyeneche Achigar, A., additional, Waeber, B., additional, Feihl, F., additional, Heinzer, R., additional, Prior, J. O., additional, Van Velzen, J. E., additional, Schuijf, J. D., additional, De Graaf, F. R., additional, De Graaf, M. A., additional, Schalij, M. J., additional, Kroft, L. J., additional, De Roos, A., additional, Jukema, J. W., additional, Van Der Wall, E. E., additional, Bax, J. J., additional, Lankinen, E., additional, Saraste, A., additional, Noponen, T., additional, Klen, R., additional, Teras, M., additional, Kokki, T., additional, Kajander, S., additional, Pietila, M., additional, Ukkonen, H., additional, Knuuti, J., additional, Pazhenkottil, A. P., additional, Nkoulou, R. N., additional, Ghadri, J. R., additional, Herzog, B. A., additional, Buechel, R. R., additional, Kuest, S. M., additional, Wolfrum, M., additional, Gaemperli, O., additional, Husmann, L., additional, Kaufmann, P. A., additional, Andreini, D., additional, Pontone, G., additional, Mushtaq, S., additional, Antonioli, L., additional, Bertella, E., additional, Formenti, A., additional, Cortinovis, S., additional, Ballerini, G., additional, Fiorentini, C., additional, Pepi, M., additional, Koh, A. S., additional, Flores, J. S., additional, Keng, F. Y. J., additional, Tan, R. S., additional, Chua, T. S. J., additional, Annoni, A. D., additional, Tamborini, G., additional, Fusari, M., additional, Bartorelli, A. L., additional, Ewe, S. H., additional, Ng, A. C. T., additional, Delgado, V., additional, Schuijf, J., additional, Van Der Kley, F., additional, Colli, A., additional, De Weger, A., additional, Marsan, N. A., additional, Yiu, K. H., additional, Ng, A. C., additional, Timmer, S. A. J., additional, Knaapen, P., additional, Germans, T., additional, Dijkmans, P. A., additional, Lubberink, M., additional, Ten Berg, J. M., additional, Ten Cate, F. J., additional, Russel, I. K., additional, Lammertsma, A. A., additional, Van Rossum, A. C., additional, Wong, Y. Y., additional, Ruiter, G., additional, Raijmakers, P., additional, Van Der Laarse, W. J., additional, Westerhof, N., additional, Vonk-Noordegraaf, A., additional, Youssef, G., additional, Leung, E., additional, Wisenberg, G., additional, Marriot, C., additional, Williams, K., additional, Etele, J., additional, Dekemp, R. A., additional, Dasilva, J., additional, Birnie, D., additional, Beanlands, R. S. B., additional, Thompson, R. C., additional, Allam, A. H., additional, Wann, L. S., additional, Nureldin, A. H., additional, Adelmaksoub, G., additional, Badr, I., additional, Sutherland, M. L., additional, Sutherland, J. D., additional, Miyamoto, M. I., additional, Thomas, G. S., additional, Harms, H. J., additional, De Haan, S., additional, Huisman, M. C., additional, Schuit, R. C., additional, Windhorst, A. D., additional, Allaart, C., additional, Einstein, A. J., additional, Khawaja, T., additional, Greer, C., additional, Chokshi, A., additional, Jones, M., additional, Schaefle, K., additional, Bhatia, K., additional, Shimbo, D., additional, Schulze, P. C., additional, Srivastava, A., additional, Chettiar, R., additional, Moody, J., additional, Weyman, C., additional, Natale, D., additional, Bruni, W., additional, Liu, Y., additional, Ficaro, E., additional, Sinusas, A. J., additional, Peix, A., additional, Batista, E., additional, Cabrera, L. O., additional, Padron, K., additional, Rodriguez, L., additional, Sainz, B., additional, Mendoza, V., additional, Carrillo, R., additional, Fernandez, Y., additional, Mena, E., additional, Naum, A., additional, Bach-Gansmo, T., additional, Kleven-Madsen, N., additional, Biermann, M., additional, Johnsen, B., additional, Aase Husby, J., additional, Rotevatn, S., additional, Nordrehaug, J. E., additional, Schaap, J., additional, Kauling, R. M., additional, Post, M. C., additional, Rensing, B. J. W. M., additional, Verzijlbergen, J. F., additional, Sanchez, J., additional, Giamouzis, G., additional, Tziolas, N., additional, Georgoulias, P., additional, Karayannis, G., additional, Chamaidi, A., additional, Zavos, N., additional, Koutrakis, K., additional, Sitafidis, G., additional, Skoularigis, J., additional, Triposkiadis, F., additional, Radovanovic, S., additional, Djokovic, A., additional, Simic, D. V., additional, Krotin, M., additional, Savic-Radojevic, A., additional, Pljesa-Ercegovac, M., additional, Zdravkovic, M., additional, Saponjski, J., additional, Jelic, S., additional, Simic, T., additional, Eckardt, R., additional, Kjeldsen, B. J., additional, Andersen, L. I., additional, Haghfelt, T., additional, Grupe, P., additional, Johansen, A., additional, Hesse, B., additional, Pena, H., additional, Cantinho, G., additional, Wilk, M., additional, Srour, Y., additional, Godinho, F., additional, Zafrir, N., additional, Gutstein, A., additional, Mats, I., additional, Battler, A., additional, Solodky, A., additional, Sari, E., additional, Singh, N., additional, Vara, A., additional, Peters, A. M., additional, De Belder, A., additional, Nair, S., additional, Ryan, N., additional, James, R., additional, Dizdarevic, S., additional, Depuey, G., additional, Friedman, M., additional, Wray, R., additional, Old, R., additional, Babla, H., additional, Chuanyong, B., additional, Maddahi, J., additional, Tragardh Johansson, E., additional, Sjostrand, K., additional, Edenbrandt, L., additional, Aguade-Bruix, S., additional, Cuberas-Borros, G., additional, Pizzi, M. N., additional, Sabate-Fernandez, M., additional, De Leon, G., additional, Garcia-Dorado, D., additional, Castell-Conesa, J., additional, Candell-Riera, J., additional, Casset-Senon, D., additional, Edjlali-Goujon, M., additional, Alison, D., additional, Delhommais, A., additional, Cosnay, P., additional, Low, C. S., additional, Notghi, A., additional, O'brien, J., additional, Tweddel, A. C., additional, Bingham, N., additional, O Neil, P., additional, Harbinson, M., additional, Lindner, O., additional, Burchert, W., additional, Schaefers, M., additional, Marcassa, C., additional, Campini, R., additional, Calza, P., additional, Zoccarato, O., additional, Kisko, A., additional, Kmec, J., additional, Babcak, M., additional, Vereb, M., additional, Vytykacova, M., additional, Cencarik, J., additional, Gazdic, P., additional, Stasko, J., additional, Abreu, A., additional, Pereira, E., additional, Oliveira, L., additional, Colarinha, P., additional, Veloso, V., additional, Enriksson, I., additional, Proenca, G., additional, Delgado, P., additional, Rosario, L., additional, Sequeira, J., additional, Kosa, I., additional, Vassanyi, I., additional, Egyed, C. S., additional, Kozmann, G. Y., additional, Morita, S., additional, Nanasato, M., additional, Nanbu, I., additional, Yoshida, Y., additional, Hirayama, H., additional, Allam, A., additional, Sharef, A., additional, Shawky, I., additional, Farid, M., additional, Mouden, M., additional, Ottervanger, J. P., additional, Timmer, J. R., additional, De Boer, M. J., additional, Reiffers, S., additional, Jager, P. L., additional, Knollema, S., additional, Nasr, G. M., additional, Mohy Eldin, M., additional, Ragheb, M., additional, Casans-Tormo, I., additional, Diaz-Exposito, R., additional, Hurtado-Mauricio, F. J., additional, Ruano, R., additional, Diego, M., additional, Gomez-Caminero, F., additional, Albarran, C., additional, Martin De Arriba, A., additional, Rosero, A., additional, Lopez, R., additional, Martin Luengo, C., additional, Garcia-Talavera, J. R., additional, Laitinen, I. E. K., additional, Rudelius, M., additional, Weidl, E., additional, Henriksen, G., additional, Wester, H. J., additional, Schwaiger, M., additional, Pan, X. B., additional, Schindler, T., additional, Quercioli, A., additional, Zaidi, H., additional, Ratib, O., additional, Declerck, J. M., additional, Alexanderson Rosas, E., additional, Jacome, R., additional, Jimenez-Santos, M., additional, Romero, E., additional, Pena-Cabral, M. A., additional, Meave, A., additional, Gonzalez, J., additional, Rouzet, F., additional, Bachelet, L., additional, Alsac, J. M., additional, Suzuki, M., additional, Louedec, L., additional, Petiet, A., additional, Chaubet, F., additional, Letourneur, D., additional, Michel, J. B., additional, Le Guludec, D., additional, Aktas, A., additional, Cinar, A., additional, Yaman, G., additional, Bahceci, T., additional, Kavak, K., additional, Gencoglu, A., additional, Jimenez-Heffernan, A., additional, Sanchez De Mora, E., additional, Lopez-Martin, J., additional, Lopez-Aguilar, R., additional, Ramos, C., additional, Salgado, C., additional, Ortega, A., additional, Sanchez-Gonzalez, C., additional, Roa, J., additional, Tobaruela, A., additional, Nesterov, S. V., additional, Turta, O., additional, Maki, M., additional, Han, C., additional, Daou, D., additional, Tawileh, M., additional, Chamouine, S. O., additional, Coaguila, C., additional, Mariscal-Labrador, E., additional, Kisiel-Gonzalez, N., additional, De Araujo Goncalves, P., additional, Sousa, P. J., additional, Marques, H., additional, O'neill, J., additional, Pisco, J., additional, Cale, R., additional, Brito, J., additional, Gaspar, A., additional, Machado, F. P., additional, Roquette, J., additional, Martinez, M., additional, Melendez, G., additional, Kimura, E., additional, Ochoa, J. M., additional, Alessio, A. M., additional, Patel, A., additional, Lautamaki, R., additional, Bengel, F. M., additional, Bassingthwaighte, J. B., additional, Caldwell, J. H., additional, Rahbar, K., additional, Seifarth, H., additional, Schafers, M., additional, Stegger, L., additional, Spieker, T., additional, Hoffmeier, A., additional, Maintz, D., additional, Scheld, H., additional, Schober, O., additional, Weckesser, M., additional, Aoki, H., additional, Matsunari, I., additional, Kajinami, K., additional, Martin Fernandez, M., additional, Barreiro Perez, M., additional, Fernandez Cimadevilla, O. V., additional, Leon Duran, D., additional, Velasco Alonso, E., additional, Florez Munoz, J. P., additional, Luyando, L. H., additional, Templin, C., additional, Veltman, C. E., additional, Reiber, J. H. C., additional, Venuraju, S., additional, Yerramasu, A., additional, Atwal, S., additional, Lahiri, A., additional, Kunimasa, T., additional, Shiba, M., additional, Ishii, K., additional, Aikawa, J., additional, Kroner, E. S. J., additional, Ho, K. T., additional, Yong, Q. W., additional, Chua, K. C., additional, Panknin, C., additional, Roos, C. J., additional, Van Werkhoven, J. M., additional, Witkowska-Grzeslo, A. J., additional, Boogers, M. J., additional, Anand, D. V., additional, Dey, D., additional, Berman, D., additional, Mut, F., additional, Giubbini, R., additional, Lusa, L., additional, Massardo, T., additional, Iskandrian, A., additional, Dondi, M., additional, Sato, A., additional, Kakefuda, Y., additional, Ojima, E., additional, Adachi, T., additional, Atsumi, A., additional, Ishizu, T., additional, Seo, Y., additional, Hiroe, M., additional, Aonuma, K., additional, Kruk, M., additional, Pracon, R., additional, Kepka, C., additional, Pregowski, J., additional, Kowalewska, A., additional, Pilka, M., additional, Opolski, M., additional, Michalowska, I., additional, Dzielinska, Z., additional, Demkow, M., additional, Stoll, V., additional, Sabharwal, N., additional, Chakera, A., additional, Ormerod, O., additional, Fernandes, H., additional, Bernardes, M., additional, Martins, E., additional, Oliveira, P., additional, Vieira, T., additional, Terroso, G., additional, Oliveira, A., additional, Faria, T., additional, Ventura, F., additional, Pereira, J., additional, Fukuzawa, S., additional, Inagaki, M., additional, Sugioka, J., additional, Ikeda, A., additional, Okino, S., additional, Maekawa, J., additional, Uchiyama, T., additional, Kamioka, N., additional, Ichikawa, S., additional, Afshar, M., additional, Alvi, R., additional, Aguilar, N., additional, Ippili, R., additional, Shaqra, H., additional, Bella, J., additional, Bhalodkar, N., additional, Dos Santos, A., additional, Daicz, M., additional, Cendoya, L. O., additional, Marrero, H. G., additional, Casuscelli, J., additional, Embon, M., additional, Vera Janavel, G., additional, Duronto, E., additional, Gurfinkel, E. P., additional, Cortes, C. M., additional, Takeishi, Y., additional, Nakajima, K., additional, Yamasaki, Y., additional, Nishimura, T., additional, Hayes Brown, K., additional, Collado, F., additional, Alhaji, M., additional, Green, J., additional, Alexander, S., additional, Vashistha, R., additional, Jain, S., additional, Aldaas, F., additional, Shanes, J., additional, Doukky, R., additional, Ashikaga, K., additional, Akashi, Y. J., additional, Uemarsu, M., additional, Kamijima, R., additional, Yoneyama, K., additional, Omiya, K., additional, Miyake, Y., additional, Brodov, Y., additional, Raval, U., additional, Berezin, A., additional, Seden, V., additional, Koretskaya, E., additional, Panasenko, T. A., additional, Matsuo, S., additional, Kinuya, S., additional, Chen, J., additional, Van Bommel, R. J., additional, Van Der Hiel, B., additional, Dibbets-Schneider, P., additional, Garcia, E. V., additional, Rutten-Vermeltfoort, I., additional, Gevers, M. M. J., additional, Verhoeven, B., additional, Dijk Van, A. B., additional, Raaijmakers, E., additional, Raijmakers, P. G. H. M., additional, Engvall, J. E., additional, Gjerde, M., additional, De Geer, J., additional, Olsson, E., additional, Quick, P., additional, Persson, A., additional, Mazzanti, M., additional, Marini, M., additional, Pimpini, L., additional, Perna, G. P., additional, Marciano, C., additional, Gargiulo, P., additional, Galderisi, M., additional, D'amore, C., additional, Savarese, G., additional, Casaretti, L., additional, Paolillo, S., additional, Cuocolo, A., additional, Perrone Filardi, P., additional, Al-Amoodi, M., additional, Thompson, E. C., additional, Kennedy, K., additional, Bybee, K. A., additional, Mcghie, A. I., additional, O'keefe, J. H., additional, Bateman, T. M., additional, Van Der Palen, R. L. F., additional, Mavinkurve-Groothuis, A. M., additional, Bulten, B., additional, Bellersen, L., additional, Van Laarhoven, H. W. M., additional, Kapusta, L., additional, De Geus-Oei, L. F., additional, Pollice, P. P., additional, Bonifazi, M. B., additional, Pollice, F. P., additional, Clements, I. P., additional, Hodge, D. O., additional, Scott, C. G., additional, De Ville De Goyet, M., additional, Brichard, B., additional, Pirotte, T., additional, Moniotte, S., additional, Tio, R. A., additional, Elvan, A., additional, Dierckx, R. A. I. O., additional, Slart, R. H. J. A., additional, Furuhashi, T., additional, Moroi, M., additional, Hase, H., additional, Joki, N., additional, Masai, H., additional, Nakazato, R., additional, Fukuda, H., additional, Sugi, K., additional, Kryczka, K., additional, Kaczmarska, E., additional, Petryka, J., additional, Mazurkiewicz, L., additional, Ruzyllo, W., additional, Smanio, P., additional, Vieira Segundo, E., additional, Siqueira, M., additional, Kelendjian, J., additional, Ribeiro, J., additional, Alaca, J., additional, Oliveira, M., additional, Alves, F., additional, Peovska, I., additional, Maksimovic, J., additional, Vavlukis, M., additional, Kostova, N., additional, Pop Gorceva, D., additional, Majstorov, V., additional, Zdraveska, M., additional, Hussain, S., additional, Djearaman, M., additional, Hoey, E., additional, Morus, L., additional, Erinfolami, O., additional, Macnamara, A., additional, Opolski, M. P., additional, Witkowski, A., additional, Berti, V., additional, Ricci, F., additional, Gallicchio, R., additional, Acampa, W., additional, Cerisano, G., additional, Vigorito, C., additional, Sciagra', R., additional, Pupi, A., additional, Sliem, H., additional, Collado, F. M., additional, Schmidt, S., additional, Maheshwari, A., additional, Kiriakos, R., additional, Mwansa, V., additional, Ljubojevic, S., additional, Sedej, S., additional, Holzer, M., additional, Marsche, G., additional, Marijanski, V., additional, Kockskaemper, J., additional, Pieske, B., additional, Ricalde, A., additional, Alexanderson, G., additional, Mohani, A., additional, Khanna, P., additional, Sinusas, A., additional, Lee, F., additional, Pinas, V. A., additional, Van Eck-Smit, B. L. F., additional, Verberne, H. J., additional, De Bruin, C. M., additional, Guilhermina, G., additional, Jimenez-Angeles, L., additional, Ruiz De Jesus, O., additional, Yanez-Suarez, O., additional, Vallejo, E., additional, Reyes, E., additional, Chan, M., additional, Hossen, M. L., additional, Underwood, S. R., additional, Karu, A., additional, Bokhari, S., additional, Pineda, V., additional, Gracia-Sanchez, L. M., additional, Garcia-Burillo, A., additional, Zavadovskiy, K., additional, Lishmanov, Y. U., additional, Saushkin, W., additional, Kovalev, I., additional, Chernishov, A., additional, Annoni, A., additional, Tarkia, M., additional, Saanijoki, T., additional, Oikonen, V., additional, Savunen, T., additional, Green, M. A., additional, Strandberg, M., additional, Roivainen, A., additional, Gaeta, M. C., additional, Artigas, C., additional, Deportos, J., additional, Geraldo, L., additional, Flotats, A., additional, La Delfa, V., additional, Carrio, I., additional, Laarse, W. J., additional, Izquierdo Gomez, M. M., additional, Lacalzada Almeida, J., additional, Barragan Acea, A., additional, De La Rosa Hernandez, A., additional, Juarez Prera, R., additional, Blanco Palacios, G., additional, Bonilla Arjona, J. A., additional, Jimenez Rivera, J. J., additional, Iribarren Sarrias, J. L., additional, Laynez Cerdena, I., additional, Dedic, A., additional, Rossi, A., additional, Ten Kate, G. J. R., additional, Dharampal, A., additional, Moelker, A., additional, Galema, T. W., additional, Mollet, N., additional, De Feyter, P. J., additional, Nieman, K., additional, Trabattoni, D., additional, Broersen, A., additional, Frenay, M., additional, Boogers, M. M., additional, Kitslaar, P. H., additional, Dijkstra, J., additional, Annoni, D. A., additional, Muratori, M., additional, Johki, N., additional, Tokue, M., additional, Dharampal, A. S., additional, Weustink, A. C., additional, Neefjes, L. A. E., additional, Papadopoulou, S. L., additional, Chen, C., additional, Mollet, N. R. 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Published
2011
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49. Monitoring diabetic nephropathy:glomerular filtration rate and abnormal albuminuria in diabetic renal disease--reproducibility, progression, and efficacy of antihypertensive intervention

Author

Mogensen, C E, Hansen, K W, Nielsen, S, Pedersen, M M, Rehling, M, and Schmitz, A

Subjects
Diabetes Complications, Diabetes Mellitus/physiopathology, Clinical Trials as Topic, Diabetic Nephropathies/etiology, Antihypertensive Agents/therapeutic use, Albuminuria/complications, Humans, Reproducibility of Results, urologic and male genital diseases, Glomerular Filtration Rate
Abstract

The principal end point in the evaluation of treatment in incipient and overt diabetic nephropathy is rate of decline in glomerular filtration rate (GFR). Therefore, information on reproducibility of GFR measurements is essential in the planning and evaluation of clinical trials. We studied reproducibility of GFR measurements in insulin-dependent and non-insulin-dependent diabetes mellitus patients using, respectively, a constant-infusion technique with urine collection and labeled iothalamate as a tracer marker and a single-shot procedure using Cr-EDTA, measuring the GFR from the decline in plasma level after bolus injection. The coefficient of variance in the insulin-dependent patients was from 7.5% to 8.8% with repeated measurements. In longitudinal studies with several measurements the mean coefficient of variances varied between 7.4% and 3.4%. In the non-insulin-dependent patients the coefficient of variances between two tests were 7.0% and 5.3% for normoalbuminuric and microalbuminuric patients, respectively. In cross-sectional studies as well as in longitudinal studies, it has been consistently shown that GFR is well preserved and at a supranormal level in patients with normoalbuminuria and microalbuminuria. A decline in GFR appears to start around the transition from microalbuminuria to overt diabetic renal disease, although more detailed studies are needed to support this finding. With regard to intervention trials, several studies document that microalbuminuria can be reduced by effective antihypertensive treatment, particularly with angiotensin-converting enzyme inhibitors, also in patients with normal or close to normal blood pressure. Preliminary results from long-term studies suggest that reduction in microalbuminuria in these patients is associated with preservation of GFR and, thus, apparently renoprotection. In patients with overt renal disease, it has been consistently shown that antihypertensive treatment reduces albuminuria as well as the rate of decline in GFR. This is also observed with combined treatment regimens, for instance beta blockers or angiotensin-converting enzyme inhibitors combined with diuretics, or the three types of drugs in combination.

Published
1993

50. Infarct size and myocardial salvage after primary angioplasty in patients presenting with symptoms for <12 h vs. 12-72 h

Author

Busk, M., primary, Kaltoft, A., additional, Nielsen, S. S., additional, Bottcher, M., additional, Rehling, M., additional, Thuesen, L., additional, Botker, H. E., additional, Lassen, J. F., additional, Christiansen, E. H., additional, Krusell, L. R., additional, Andersen, H. R., additional, Nielsen, T. T., additional, and Kristensen, S. D., additional

Published
2009
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