Search

Your search keyword '"RCC carcinogenesis"' showing total 2 results
Start Over Descriptor "RCC carcinogenesis"
2 results on '"RCC carcinogenesis"'

1. Metabolic alterations in renal cell carcinoma.

Author

Massari, Francesco, Ciccarese, Chiara, Santoni, Matteo, Brunelli, Matteo, Piva, Francesco, Modena, Alessandra, Bimbatti, Davide, Fantinel, Emanuela, Santini, Daniele, Cheng, Liang, Cascinu, Stefano, Montironi, Rodolfo, and Tortora, Giampaolo

Abstract

Renal cell carcinoma (RCC) is a metabolic disease, being characterized by the dysregulation of metabolic pathways involved in oxygen sensing (VHL/HIF pathway alterations and the subsequent up-regulation of HIF-responsive genes such as VEGF, PDGF, EGF, and glucose transporters GLUT1 and GLUT4, which justify the RCC reliance on aerobic glycolysis), energy sensing (fumarate hydratase-deficient, succinate dehydrogenase-deficient RCC, mutations of HGF/MET pathway resulting in the metabolic Warburg shift marked by RCC increased dependence on aerobic glycolysis and the pentose phosphate shunt, augmented lipogenesis, and reduced AMPK and Krebs cycle activity) and/or nutrient sensing cascade (deregulation of AMPK-TSC1/2-mTOR and PI3K-Akt-mTOR pathways). We analyzed the key metabolic abnormalities underlying RCC carcinogenesis, highlighting those altered pathways that may represent potential targets for the development of more effective therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

2. Metabolic alterations in renal cell carcinoma

Author

Rodolfo Montironi, Alessandra Modena, Chiara Ciccarese, Stefano Cascinu, Matteo Santoni, Giampaolo Tortora, Daniele Santini, Liang Cheng, Emanuela Fantinel, Francesco Massari, Francesco Piva, Davide Bimbatti, Matteo Brunelli, Massari, F., Ciccarese, C., Santoni, M., Brunelli, M., Piva, F., Modena, A., Bimbatti, D., Fantinel, E., Santini, D., Cheng, L., Cascinu, S., Montironi, R., and Tortora, G.

Subjects
medicine.medical_specialty, Nutrient sensing, Biology, Pentose phosphate pathway, urologic and male genital diseases, medicine.disease_cause, Internal medicine, medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, RCC carcinogenesis, Carcinoma, Renal Cell, AMPK, General Medicine, Kidney Neoplasms, female genital diseases and pregnancy complications, Renal cell carcinoma, Citric acid cycle, Metabolic pathway, Endocrinology, Oncology, Anaerobic glycolysis, Metabolic pathways, Lipogenesis, Therapeutic strategies, Cancer research, Carcinogenesis, Metabolic Networks and Pathways
Abstract

Renal cell carcinoma (RCC) is a metabolic disease, being characterized by the dysregulation of metabolic pathways involved in oxygen sensing (VHL/HIF pathway alterations and the subsequent up-regulation of HIF-responsive genes such as VEGF, PDGF, EGF, and glucose transporters GLUT1 and GLUT4, which justify the RCC reliance on aerobic glycolysis), energy sensing (fumarate hydratase-deficient, succinate dehydrogenase-deficient RCC, mutations of HGF/MET pathway resulting in the metabolic Warburg shift marked by RCC increased dependence on aerobic glycolysis and the pentose phosphate shunt, augmented lipogenesis, and reduced AMPK and Krebs cycle activity) and/or nutrient sensing cascade (deregulation of AMPK-TSC1/2-mTOR and PI3K-Akt-mTOR pathways). We analyzed the key metabolic abnormalities underlying RCC carcinogenesis, highlighting those altered pathways that may represent potential targets for the development of more effective therapeutic strategies.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results