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Introduction: birth, although a physiological act, it is followed by the stress response from mothers and newborns. The mode of delivery and the type of obstetrical anesthesia may affect the level of oxidative stress. Uncomplicated vaginal delivery exposes mothers and newborns to a state of increased oxidative stress. Ending the pregnancy by cesarean section has become more common, and the modem spinal anesthesia is preferred to obstetric anesthesia. Direct effects of anesthesia on neonatal outcome, complications related to the birth and the newborn, as well as the oxidative stress that occurs during childbirth, have not been not studied in our community. The activity of the GPx enzyme in infants at birth has been insufficiently addressed in the professional written material it the world in general, and in pregnant women it is unknown. Aim: To determine the effect of mode of delivery and the type of obstetric anesthesia at the level of oxidative stress and complications in newborns and mothers. Methods: A prospective clinical study was conducted at the Department of Gynecology and Obstetrics, Clinical Center of Vojvodina in Novi Sad. The study included 150 healthy, term infants, delivered by a planned cesarean section with general or spinal anesthesia, as well as in a natural way, and their 150 mothers. Depending on the mode of delivery and the type of obstetric anesthesia, the newborns and mothers were divided into six groups of 50. In all six tested groups, venous blood samples were taken a few minutes after the birth, together with certain laboratory markers of oxidative stress (TBARS and GPx), lactate and gas analysis. The general condition and potential complications of the newborns and mothers during childbirth and hospitalization were monitored and evaluated. Results: The values of Apgar score after 1 and 5 minutes were significantly higher (p < 0.01) in infants who were born by cesarean section under spinal anesthesia . The highest concentration of TBARS and the lowest concentration of GPx were present in infants who were born naturally. The lowest TBARS values had newborns and their mothers from the group of spinal anesthesia, while the concentration of GSH was highest in the group of general anesthesia. The newborns had higher values of markers of oxidative stress than their mothers. The most common complications were maternal hypotension in spinal and general anesthesia in PDPH. Statistically, a significantly (p < 0.001) higher postpartum pain was experienced by the mothers who delivered their babies naturally and the lowest by those who gave birth by caesarean section under spinal anesthesia. Conclusions: The markers of oxidative stress, clinical and laboratory parameters in newborns and mothers, indicate the advantages of the electoral caesarean section over a natural birth, and those of spinal anesthesia over general anesthesia.

Sepsa je klinički sindrom karakterisan prisustvom infekcije i neadekvatnog sistemskog inflamatornog odgovora organizma i može se komplikovati razvojem septičnog šoka i multiorganske disfunkcije. Sepsa predstavlja jedan od najvećih zdravstveniih problema današnjice širom sveta sa visokim mortalitetom. Takođe, ona je glavni preventabilni uzrok smrti unutar bolnica. Poznavanje i jasno definisanje prediktivnih faktora mortaliteta kod pacijenata u sepsi pomaže u bržoj identifikaciji kritično obolelih pacijenata i pravovremenom ordiniranju adekvatne terapije, te doprinosi razvoju novih strategija primarne i sekundarne prevencije. Kreiranje modela za predikciju mortaliteta pruža mogućnost kvantifikacije težine stanja pacijenata, što ih čini neizostavnim u naučno-istraživačkom radu, pogotovo u oblastima poboljšanja kvaliteta i personalizovane medicine. Opšti cilj ovog istraživanja je bio da se utvrde nezavisni prediktori mortaliteta u sepsi, kao i da se formira prediktivni model smrtnog ishoda. Specifični ciljevi su bili da se utvrdi korelacija koncetracije laktata, vrste prijema i komorbiditeta sa mortalitetom u sepsi. Ispitivanje je sprovedeno kao opservaciono, neinterventno, delom retrospektivno, delom prospektivno. Obuhvaćena je konsekutivna serija pacijenata sa sepsom primljenih u Jedinicu intenzivnog lečenja Instituta za plućne bolesti Vojvodine u Sremskoj Kamenici od 01.01.2017. do 31.07.2019. godine. Metodama logističke regresivne analize su procenjeni faktori rizika za 28-dnevni mortalitet. Nakon identifikacije nezavisnih prediktora konstruisan je i validiran prediktivni model. Studijom je ukupno obuhvaćeno 307 pacijenata sa sepsom od kojih je 52,4% preminulo unutar 28 dana od prijema. Nije postojala statistički značajna razlika (p>0,05) u mortalitetu od sepse u odnosu na vrstu prijema pacijenata u jedinicu intenzivne nege. Vrednost laktata pri prijemu i vrednost Čarlson skora je bila u pozitivnoj korelaciji sa mortalitetom. Konačni model predikcije mortaliteta sadrži sledeće varijable: vrednost APAČE 2 skora preko 20, SOFA skora iznad 7, Čarlsonovog indeksa komorbiditeta preko 3 i koncentracija laktata u serumu iznad 2,32 mmol/l. Formiran model predikcije je pokazao dobru diskriminaciju (AUC 0,754: 95% IP=0,700-0,808), a ispravno je klasifikovao 67,4% pacijenata, sa 70,8% osetljivosti i 63,7% specifičnost. Zaključujemo da su nezavisni prediktori mortaliteta kod pacijenata u sepsi: viša koncentracija laktata merena u prva 24 časa od prijema u jedinicu intenzivnog lečenja, više vrednosti APAČE 2 skora, više vrednosti SOFA skora i više vrednosti Čarlsonovog indeksa komorbiditeta. Za razliku od laktata i komorbiditeta, ne postoji statistički značajna razlika u mortalitetu od sepse u odnosu na vrstu prijema. Konstruisan model predikcije je pokazao dobru prediktivnu validnost, uporedivu sa ostalim najčešće korišćenim modelima., Sepsis is a clinical syndrome characterized by both the presence of the infection and inadequate systemic inflammatory organism response that can be additionally complicated by the development of septic shock and multiorgan dysfunction. Recently sepsis is defined as one of the biggest health problems in the world with high mortality and a major preventable cause of death within hospitals. Knowledge and clear definition of predictive mortality factors for patients with sepsis contribute to faster identification of critically ill patients and timely administration of adequate therapy, as well as to the development of new strategies for primary and secondary prevention. Creating a model for predicting mortality provides the possibility of quantifying the severity of the patients' condition that can be indispensable in scientific research, especially in the areas of quality improvement and personalized medicine. The overall aim of this thesis was to determine independent predictors of mortality in sepsis, as well as to form a predictive model of mortality. Whereas specific objectives of the thesis were to determine the correlation of lactate concentration, type of admission and comorbidity with mortality for sepsis. The investigation was conducted as observational, noninterventional, partly retrospectively, partly prospectively. The research included consecutive series of patients with sepsis admitted to the Intensive Care Unit of the Institute for Pulmonary Diseases of Vojvodina in Sremska Kamenica from 01.01.2017 to 31.07.2019. Risk factors for 28-day mortality were estimated by logistic regression analysis methods. After the estimation of independent predictors, a predictive model was constructed and validated. The study involved a total of 307 patients with sepsis, of whom 52.4% died within 28 days of admission. There was no statistically significant difference (p>0.05) in mortality from sepsis in relation with the admission type of patients to the intensive care unit. The value of lactate at the time of admission and the value of the Charlson score were positively correlated with mortality. The final mortality prediction model contained the following variables: APACHE II score above 20, SOFA score above 7, Charlson comorbidity index over 3, and serum lactate concentrations above 2.32mmol/l. The prediction model formed showed good discrimination (AUC 0.754: 95% CI = 0.700-0.808), and were correctly classified 67.4% of patients, with 70.8% sensitivity and 63.7% specificity. It can be concluded that independent predictors of mortality in patients with sepsis are: higher lactate concentration measured in the first 24h of admission to the Intensive Care Unit, higher APACHE II scores, higher SOFA scores, and higher Charlson comorbidity index values. Unlike lactate and comorbidity, there is no statistically significant difference in mortality from sepsis in relation with the admission type. The constructed prediction model exhibited good predictive validity, comparable to other commonly used models.

Sepsa je klinički sindrom karakterisan prisustvom infekcije i neadekvatnog sistemskog inflamatornog odgovora organizma i može se komplikovati razvojem septičnog šoka i multiorganske disfunkcije. Sepsa predstavlja jedan od najvećih zdravstveniih problema današnjice širom sveta sa visokim mortalitetom. Takođe, ona je glavni preventabilni uzrok smrti unutar bolnica. Poznavanje i jasno definisanje prediktivnih faktora mortaliteta kod pacijenata u sepsi pomaže u bržoj identifikaciji kritično obolelih pacijenata i pravovremenom ordiniranju adekvatne terapije, te doprinosi razvoju novih strategija primarne i sekundarne prevencije. Kreiranje modela za predikciju mortaliteta pruža mogućnost kvantifikacije težine stanja pacijenata, što ih čini neizostavnim u naučno-istraživačkom radu, pogotovo u oblastima poboljšanja kvaliteta i personalizovane medicine. Opšti cilj ovog istraživanja je bio da se utvrde nezavisni prediktori mortaliteta u sepsi, kao i da se formira prediktivni model smrtnog ishoda. Specifični ciljevi su bili da se utvrdi korelacija koncetracije laktata, vrste prijema i komorbiditeta sa mortalitetom u sepsi. Ispitivanje je sprovedeno kao opservaciono, neinterventno, delom retrospektivno, delom prospektivno. Obuhvaćena je konsekutivna serija pacijenata sa sepsom primljenih u Jedinicu intenzivnog lečenja Instituta za plućne bolesti Vojvodine u Sremskoj Kamenici od 01.01.2017. do 31.07.2019. godine. Metodama logističke regresivne analize su procenjeni faktori rizika za 28-dnevni mortalitet. Nakon identifikacije nezavisnih prediktora konstruisan je i validiran prediktivni model. Studijom je ukupno obuhvaćeno 307 pacijenata sa sepsom od kojih je 52,4% preminulo unutar 28 dana od prijema. Nije postojala statistički značajna razlika (p>0,05) u mortalitetu od sepse u odnosu na vrstu prijema pacijenata u jedinicu intenzivne nege. Vrednost laktata pri prijemu i vrednost Čarlson skora je bila u pozitivnoj korelaciji sa mortalitetom. Konačni model predikcije mortaliteta sadrži sledeće varijable: vrednost APAČE 2 skora preko 20, SOFA skora iznad 7, Čarlsonovog indeksa komorbiditeta preko 3 i koncentracija laktata u serumu iznad 2,32 mmol/l. Formiran model predikcije je pokazao dobru diskriminaciju (AUC 0,754: 95% IP=0,700-0,808), a ispravno je klasifikovao 67,4% pacijenata, sa 70,8% osetljivosti i 63,7% specifičnost. Zaključujemo da su nezavisni prediktori mortaliteta kod pacijenata u sepsi: viša koncentracija laktata merena u prva 24 časa od prijema u jedinicu intenzivnog lečenja, više vrednosti APAČE 2 skora, više vrednosti SOFA skora i više vrednosti Čarlsonovog indeksa komorbiditeta. Za razliku od laktata i komorbiditeta, ne postoji statistički značajna razlika u mortalitetu od sepse u odnosu na vrstu prijema. Konstruisan model predikcije je pokazao dobru prediktivnu validnost, uporedivu sa ostalim najčešće korišćenim modelima. Sepsis is a clinical syndrome characterized by both the presence of the infection and inadequate systemic inflammatory organism response that can be additionally complicated by the development of septic shock and multiorgan dysfunction. Recently sepsis is defined as one of the biggest health problems in the world with high mortality and a major preventable cause of death within hospitals. Knowledge and clear definition of predictive mortality factors for patients with sepsis contribute to faster identification of critically ill patients and timely administration of adequate therapy, as well as to the development of new strategies for primary and secondary prevention. Creating a model for predicting mortality provides the possibility of quantifying the severity of the patients' condition that can be indispensable in scientific research, especially in the areas of quality improvement and personalized medicine. The overall aim of this thesis was to determine independent predictors of mortality in sepsis, as well as to form a predictive model of mortality. Whereas specific objectives of the thesis were to determine the correlation of lactate concentration, type of admission and comorbidity with mortality for sepsis. The investigation was conducted as observational, noninterventional, partly retrospectively, partly prospectively. The research included consecutive series of patients with sepsis admitted to the Intensive Care Unit of the Institute for Pulmonary Diseases of Vojvodina in Sremska Kamenica from 01.01.2017 to 31.07.2019. Risk factors for 28-day mortality were estimated by logistic regression analysis methods. After the estimation of independent predictors, a predictive model was constructed and validated. The study involved a total of 307 patients with sepsis, of whom 52.4% died within 28 days of admission. There was no statistically significant difference (p>0.05) in mortality from sepsis in relation with the admission type of patients to the intensive care unit. The value of lactate at the time of admission and the value of the Charlson score were positively correlated with mortality. The final mortality prediction model contained the following variables: APACHE II score above 20, SOFA score above 7, Charlson comorbidity index over 3, and serum lactate concentrations above 2.32mmol/l. The prediction model formed showed good discrimination (AUC 0.754: 95% CI = 0.700-0.808), and were correctly classified 67.4% of patients, with 70.8% sensitivity and 63.7% specificity. It can be concluded that independent predictors of mortality in patients with sepsis are: higher lactate concentration measured in the first 24h of admission to the Intensive Care Unit, higher APACHE II scores, higher SOFA scores, and higher Charlson comorbidity index values. Unlike lactate and comorbidity, there is no statistically significant difference in mortality from sepsis in relation with the admission type. The constructed prediction model exhibited good predictive validity, comparable to other commonly used models.

Hirurška inetrvencija aktivira odgovor organizma na stres, pokreću se neuroendokrine promene u organizmu, što rezultira neželjenom hemodinamskom nestabilnošću, promenama metabolizma, endokrinog i imunog sistema. Cilj ovog istraživanja je bio da se utvrdi uticaj kaudalnog bloka na nivo perioperativnog stresa i njegova efikasnot u zbrinjavanju intra- i postoperativnog bola. Ovo prospektivno, randomizirano kliničko ispitivanje obuhvatalo je 80 dečaka, uzrasta 2-5godina, kojima su bile indikovane urološke operacije. Jedna grupa (n = 38) je primila opštu anesteziju, a druga (n = 38) opštu anesteziju sa kaudalnim blokom. Mereni su intraoperativno hemodinamski parametri u 8 merenja, ukupna potrošnja svih datih lekova i intenzitet bola u 3 navrata postoperativno. Uzorci krvi uzeti su pre uvoda u anesteziju i nakon buđenja pacijenta, i ispitivan je nivo glukoze, kortizola, leukocita, leukocitarne formule, pH i laktata. Deca koja su primila kaudalni blok imala su, postoperativno, značajno niži nivo glukoze u serumu (p

Hirurška inetrvencija aktivira odgovor organizma na stres, pokreću se neuroendokrine promene u organizmu, što rezultira neželjenom hemodinamskom nestabilnošću, promenama metabolizma, endokrinog i imunog sistema. Cilj ovog istraživanja je bio da se utvrdi uticaj kaudalnog bloka na nivo perioperativnog stresa i njegova efikasnot u zbrinjavanju intra- i postoperativnog bola. Ovo prospektivno, randomizirano kliničko ispitivanje obuhvatalo je 80 dečaka, uzrasta 2-5godina, kojima su bile indikovane urološke operacije. Jedna grupa (n = 38) je primila opštu anesteziju, a druga (n = 38) opštu anesteziju sa kaudalnim blokom. Mereni su intraoperativno hemodinamski parametri u 8 merenja, ukupna potrošnja svih datih lekova i intenzitet bola u 3 navrata postoperativno. Uzorci krvi uzeti su pre uvoda u anesteziju i nakon buđenja pacijenta, i ispitivan je nivo glukoze, kortizola, leukocita, leukocitarne formule, pH i laktata. Deca koja su primila kaudalni blok imala su, postoperativno, značajno niži nivo glukoze u serumu (p lekova., Surgery generates a neuroendocrine stress response, resulting in undesirable haemodynamic instability, alterations in metabolic response and malfunctioning of the immune system. The aim of this research was to determine the effectiveness of caudal blocks in intra- and postoperative pain management and in reducing the stress response in children during the same periods. This prospective, randomized clinical trial included 80 patients scheduled for elective urological operations. One group (n = 38) received general anaesthesia and the other (n = 38) received general anaesthesia with a caudal block. Haemodynamic paramethers, drug consumption and pain intensity were measured. Blood samples for serum glucose, cortisol level, leukocytes, pH and lactate level were taken before anaesthesia induction and after awakening the patient. Children who received a caudal block had, postoperativly, significantly lower serum glucose (p < 0.01), cortisol concentrations (p < 0.01), leukocytes (p

Doktorski rad Realitet i metafora materijala kože u prostoru slike, bavi se aspektima slike u odnosu na materiju, materijal, formu i prostor. Akcenat je naročito stavljen na razumevanje odnosa slika – objekat – prostor, u savremenom shvatanju slike i njena nova definicija i pozicija u modernoj umetnosti. Ovo istraživanje, zasniva se na iskustvu u prethodnim projektima i ciklusima u slikarstvu. To su iskustva u prethodna dva istraživanja: U totalu slike (2013) i Opredmećena slika (2017), gde se upotrebom neslikarskih materijala u slici, i njihovim delovanjem (ekspresivnošću, taktilnošću, energijom), specifičnim načinom izlaganja u galerijskom prostoru, istražuje prostor unutrašnjeg doživljaja na relaciji posmatrač – slika. Povod i namera ove doktorske teze, bila bi sagledavanje, uočavanja i mapiranja odnosa realnog spoljnog i irealnog, unutrašnjeg viđenja slike kroz primenu neslikarskog materijala kože u odnosu na čula i mogućnost vizibilnosti posmatrača i njegove interakcije sa slikom. Na ovaj način slika se iz kolorističke površine prevodi u novi oblik – predmet, trodimezionalnosti i oprostorenost. Otvara se jedan specifičan prostor, u kome se stvara mogućnost dijaloga i novo iščitavanje slike i njene nove definisanosti u obliku – predmetu. Sve ključne teorije, metode i tehnike slikarstva XX i XXI veka zasnivaju se na pretpostavci da je u kreativnom procesu veoma važan rad sa čulima, a posebno rad na mogućnosti vizuelizacije. U ovom radu ispituje se na kojim operativnim principima se zasniva vizuelno mišljenje i vizuelizacija i kako ti različiti principi utiču na kreativnost i stvaranje slike. U fokusu istraživanja u ovom doktorskom radu je proces nastajanja proširenog polja slike primenom materijala u strukturi slike, kroz proces vizuelizacije prostora slike, spolja ka unutrašnjem viđenju i stvaranju nove forme, objekta. Suštinu tog procesa nosi materijal prirodne kože. Primaran deo istraživanja jeste uspostavljanje odnosa prema materijalu i njegova upotreba na slici, ali i analiza karakteristika i funkcija mentalnih slika, naročito imaginativnih procesa odnosa spolja – unutra – granica. Razmatrane su različite funkcije imaginacije i vizuelizacije u svetlu raznih slikarskih praksi u modernoj umetnosti, kao i analiza shvatanja odnosa intuitivnog i racionalnog načela. Teoretska analiza je utemeljena u komparaciji različitih filozofskih koncepcija imaginacije i vizuelizacije uz poseban osvrt na uvide fenomenologije, teoretske radove ruskih avangardnih umetnika V. Kandiski, K. Maljeviča, u psihološkim istraživanjima Gestalta, umetničkim pravcima simbolizma, dadaizma i istočnjačkih religioznih učenja (zen), savremenim praksama strukturalizma i novim virtuelnim medijima (internet, mobilni telefon) i drugim digitalnim medijima. U praktičnom delu israživanja, u radu sa neslikarskim materijalom prirodnom kožom, gradeći sliku van njene dvodimenzionalne površine analizira se na koje načine primenom raznih tehnika slikarske prakse, formatom slike, konceptom izlaganja u prostoru, je moguće uvesti posmatrača u jedinstven doživljaj viđenja slike, njene strukture i same egzistencije slike kao takve. Doctoral work The Reality and Metaphor of the Leather Material in the Space of Image deals with aspects of the image in relation to matter, material, form and space. Particular emphasis has been put on the understanding of the image - object - space relationship, in the contemporary understanding of the image and its new definition and position in modern art. This research is based on experience in previous projects and cycles in painting. These are the experiences in the previous two researches: The total picture (2013) and the Compiled picture (2017), where the use of non-painted materials in the picture, and their actions (expresiveness, tactility, energy), the specific way of exposure in the gallery space, experiences on an observer – image relation. The reason and intention of this doctoral thesis would be to look at, visualize and map the relationship of real external and real, internal vision of the image through the application of non - painted skin material in relation to the senses and the possibility of visibility of the observer and its interaction with the image. In this way, the painting is transformed from the colored surface into a new shape - object, three - dimensionality and space. A specific space opens, in which the possibility of dialogue and the new reading of the image and its new definition in the form - object is created. All the key theories, methods and techniques of painting of the XX and XXI centuries are based on the assumption that in the creative process is very important work with senses, and especially work on the possibilities of visualization. In this work, it examines which operational principles are based on visual thinking and visualization, and how these different principles influence creativity and the creation of a image. In the focus of research in this doctoral thesis is the process of creating an enlarged field of the image by applying material in the structure of the image, through the process of visualizing the image space, from the outside towards the inner vision and creating a new form, the object. The essence of this process carries the material of natural skin (leather). The primary part of the research is to establish a relationship with the material and its use in the picture, as well as an analysis of the characteristics and functions of mental images, especially the imaginative processes of outside - inside - border. Different functions of imagination and visualization were considered in the light of various artistic practices in modern art. As well as an analysis of the understanding of the relationship of an intuitive and rational principle. Theoretical analysis is based on a comparison of the different philosophical conceptions of imagination and visualization, with a special review of the insights of phenomenology, theoretical works of Russian avant-garde artists V.Kandiski, K.Maljevic, psychological research of Gestaltt, artistic directions of symbolism, dadaism and eastern religious teachings, modern practices of structuralism and new virtual media (the Internet, mobile phone) and other digital media. In the practical part of the research, in the work with non - painted material with natural skin (leather), the construction of the image outside its two - dimensional surface analyzes the ways in which the application of various techniques of painting practice, the image format, the concept of exposure in space, it is possible to introduce the viewer into a unique experience of seeing the image, and the very existence of the image as such.

Sve veća potreba za izvođenjem kolonoskopije u dijagnostičke ili terapijske svrhe nameće potrebu za usavršavanjem ove endoskopske procedure. Izvođenje kolonoskopije u opštoj, intravenskoj anesteziji, moglo bi u značajnoj meri olakšati njeno izvođenje, poboljšati podnošenje ove procedure od strane ispitanika i omogućiti otkrivanje većeg broja pacijenata sa potencijalno malignim bolestima debelog creva. Cilj ispitivanja je bio utvrditi da li primena opšte intravenske anestezije tokom kolonoskopije povećava broj totalnih kolonoskopija i skraćuje vreme intubacije cekuma, povećava broj viđenih patoloških procesa i smanjuje osećaj bola i učestalost neželjenih reakcija. Primena opšte intravenske anestezije značajno je povećala broj totalnih kolonoskopija u 94.3% ispitanika u odnosu na 78.7% totalnih kolonoskopija kontrolne grupe i skratila vreme intubacije cekuma, značajno je povećala broj viđenih patoloških promena u 46.7% ispitanika u odnosu na broj viđenih patoloških promena u 28.8% ispitanika kontrolne grupe i značajno je smanjila intenzitet bola i učestalost neželjenih reakcija. U kontrolnoj grupi ispitanika skalom bola nakon kolonoskopije ustanovljen je značajno veći intenzitet bola u poređenju sa ispitanicima ekperimentalne grupe. Na Likertovoj skali zadovoljstva ustanovljena je značajno bolja kontrola bola i lični stav lekara u ekperimentalnoj grupi, dok su poseta ustanovi i procedura, razumevanje procedure, tehnička veština lekara, lični stav medicinskih sestara i drugog tehničkog osoblja značajno bolje ocenjeni u kontrolnoj grupi. Od svih ispitivanih faktora na zadovoljstvo obe grupe pacijenata značajno su uticali: način izvođenja procedure, bol, uočene patološke promene i intubacija cekuma. U kontrolnoj grupi ispitanika između skale zadovoljstva i skale bola ustanovljena je značajna negativna korelacija. U kontrolnoj grupi se 80,1% pacijenata izjasnilo da bi ponovnu kolonoskopiju uradili u opštoj intravenskoj anesteziji u poređenju sa svim pacijentima eksperimentalne grupe koji ne bi menjali način izvođenja ponovne procedure. Primena opšte intravenske anestezije tokom kolonoskopije povećava broj totalnih kolonoskopija i uočenih patoloških promena, smanjuje učestalost i intenzitet neželjenih reakcija povećavajući zadovoljstvo pacijenata, što bi prevashodno moglo imati značaja u skriningu karcinoma debelog creva. Potrebno je proširiti ispitivanje primene opšte intravenske anestezije u drugim endoskopskim procedurama kako bi bila uvedena u svakodnevnoj kliničkoj praksi., An increasing need to perform colonoscopy for diagnostic or therapeutic purposes imposed the need for mastering this endoscopic procedure. Performing colonoscopy in general intravenous anesthesia could greatly ease the procedure, make it more comfortable for patients and it could enable detecting a higher number of patients with occult malignant diseases of the colon. The aim of this paper was to determine if the implementation of general intravenous anesthesia during colonoscopy increases the number of total colonoscopies and shortens the time of cecum intubation, increases the number of familiar pathological processes and decreases the sensation of pain as well as the frequency of side reactions. The implementation of general intravenous anesthesia has significantly increased the number of total colonoscopies in 94.3% of examined patients in relation to 78.7% of total colonoscopies of the control group and shortened the time of cecum intubation. It has significantly increased the number of familiar pathological changes in 46.7% of the patients in relation to the number of familiar pathological changes in 28.8% patients of the control group and significantly decreased pain intensity and the frequency of side reactions. A statistically greater pain intensity after colonoscopy was determined by the pain scale in the control group in comparison to the examinees of the experimental group. Likert satisfaction scale has shown that the experiment group assessed pain control and doctors’ opinion as significantly better, while the institution visits and the procedure, understanding the procedure, doctors’ technical skills, nurses’ and technical personnel’s personal opinions were assessed as significantly better in the control group. Out of all the examined factors on the satisfaction of both groups, the following ones had a significant inluence: the way the procedure was done, the level of pain, detected pathological changes and cecum intubation. A significanlty negative correlation was determined between the scale of satisfaction and the scale of pain in the control group. 80.1% of the control group patients stated that they would undergo a general anesthesia colonoscopy again in comparison to all the patients of the experimental group who would not change the way the procedure was previously done. The implementation of general intravenous anesthesia in the course of colonoscopy increases the number of total colonoscopies and detected pathological changes, decreases the frequency and intensity of side-effects therefore it enhances patients' sastisfaction, which could play a major role in colon cancer screening. It is necessary to extend the implementation of general intravenous anesthesia in other endoscopic procedures in order to introduce it in everyday clinical practice.