1. Distinct Xp11.2 breakpoints in two renal cell carcinomas exhibiting X;autosome translocations
- Author
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E. van den Berg, M.J.M. Wilbrink, A.J.M. Braam, R.P. Folkers, A. Geurts van Kessel, Marian A. J. Weterman, B. de Jong, Stephan Störkel, Trijnie Dijkhuizen, and Other departments
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,congenital, hereditary, and neonatal diseases and abnormalities ,X Chromosome ,Chromosomal translocation ,Biology ,Translocation, Genetic ,CLASSIFICATION ,CHILD ,Genetics ,medicine ,Carcinoma ,Humans ,De rol van chromosoomafwijkingen en (anti-)oncogenen in humane tumoren ,Carcinoma, Renal Cell ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,In Situ Hybridization, Fluorescence ,X chromosome ,Aged ,Autosome ,Breakpoint ,Cytogenetics ,Karyotype ,ADENOCARCINOMA ,Middle Aged ,medicine.disease ,Molecular biology ,TUMORS ,CYTOGENETICS ,Kidney Neoplasms ,Chromosome Banding ,Adenocarcinoma ,The role of chromosomal aberrations and (anti-)oncogenes in human tumours - Abstract
Several human renal cell carcinomas with X;autosome translocations have been reported in recent years. The t(X; I)(p11.2;q21) appears to be a specific primary anomaly, suggesting that tumors with this translocation form a distinct subgroup of RCC. Here we report two new cases, one with a t(X;10)(p11.2;q23), the other with a t(X;1)(p11.2;p34). The common breakpoint in Xp11.2 suggests that they belong to the above-mentioned subset of RCC. Using FISH in conjunction with X-specific YAC clones, we demonstrate that the two new cases exhibited distinct breakpoints within Xp11.2. (C) 1995 Wiley-Liss, Inc.
- Published
- 1995
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