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Multiple bone metastases management requires pain relief and mechanical stability to achieve functional improvement. Inducing tumour cell necrosis is important for local tumour control. A two dimensional thermal and transient numerical model based on finite element method was built to predict the temperature distribution produced by cement polymerization when mimicking a femoral lytic lesion. The bone cement filled the metastatic lesion and titanium, or CF/PEEK intramedullary nail was used. Additionally, two different cement types were compared. Cement A has low viscosity and cement B high viscosity. The titanium intramedullary nail has shown to be the best heat conductor. Significant thermal necrosis occurs with a thin or thick cement amount, and either with low or high viscosity cement types. When choosing to optimize this synergistic effect, a titanium intramedullary nail and cement A induce the largest necrotic area. The results play a role in the multidisciplinary management of long bone metastases.

The main goal of this work is to study the influence on mechanical bone behaviour using different thread profiles shapes considered in titanium dental implants. The biomechanical behaviour of bone and thread implant profile play an important role on the study of stresses and strains at bone-implant interface. The success of dental surgeries depends on the mechanical stimulus (stress, strain, strain rate, strain energy, density…) between the bone and the implant. In this work, four different threads profiles shapes were considered (Model 1 - Plateau typeA, Model 2 - Plateau typeB, Model 3 - Triangular, Model 4 - Rectangular) and for each one two internal diameters equal to 4 and 6mm. The results about the chosen thread profile shape and the diameter give additional information about the transferred stresses between bone-implant to guarantee the stability of the implant and sustain loads during or after osseointegration.