Search

Your search keyword '"R.J. Porte"' showing total 10 results
Start Over Author "R.J. Porte"
10 results on '"R.J. Porte"'

1. Type of calcineurin inhibitor and long-term outcomes following liver transplantation in patients with primary biliary cholangitis – an ELTR study

Author

Maria C. van Hooff, Rozanne C. de Veer, Vincent Karam, Rene Adam, Pavel Taimr, Wojciech G. Polak, Hasina Pashtoun, Sarwa Darwish Murad, Christophe Corpechot, Darius Mirza, Michael Heneghan, Peter Lodge, Gabriel C. Oniscu, Douglas Thorburn, Michael Allison, Herold J. Metselaar, Caroline M. den Hoed, Adriaan J. van der Meer, Gabriel Oniscu, Johann Pratschke, Derek Manas, William Bennet, Pal-Dag Line, Emir Hot, Krzysztof Zieniewicz, Bo Goran Ericzon, Jiri Fronek, Jurgen L. Klempnauer, Allan Rasmussen, Renato Romagnoli, Petr Nemec, Arno Nordin, Andreas Paul, Paolo De Simone, R.J. Porte, Gabriela Berlakovich, Daniel Cherqui, Jacques Pirenne, Etienne Sokal, Giorgio Rossi, Daniel Candinas, Philippe Bachellier, Oleg Rummo, Karim Boudjema, Anna Mrzljak, Olivier Soubrane, Herold Metselaar, Stefan Schneeberger, Francis Navarro, Thierry Berney, Christophe Duvoux, Michele Colledan, Luciano De Carlis, Olivier Boillot, Jean Hardwigsen, Francois Rene Pruvot, Bertrand Suc, Marco Vivarelli, Pierre Alain Clavien, Hauke Lang, Maciej Kosieradzki, Frederik Berrevoet, Bruno Heyd, Matteo Cescon, Laurence Chiche, Eberhard Kochs, Umberto Baccarani, Olivier Detry, Michael Bartels, Massimo Rossi, Olivier Scatton, Vasileios Papanikolaou, Ian Alwayn, Peter Schemmer, N. Senninger, Christian Ducerf, Fabrizio Di Benedetto, Giuseppe Tisone, Silvio Nadalin, Zoltan Mathe, Marija Ribnikar, Utz Settmacher, Thomas Becker, Nuno Silva, Jorge Daniel, Irinel Popescu, Valerio Lucidi, Wolf O. Bechstein, Thomas Decaens, Jean Gugenheim, Salvatore Gruttadauria, Frausto Zamboni, Murat Zeytunlu, Jorg C. Kalff, Toomas Vali, Yaman Tokat, Ernst Klar, Julius Janek, Murat Kilic, Krum Katzarov, Lutz Fisher, Emmanuel Buc, Marco Castagneto, Tarkan Unek, Lubomir Spassov, Dirk Stippel, Christiane Bruns, Hans Schlitt, Ephrem Salame, Piotr Kalicinski, and Koray Acarli

Subjects
Calcineurin inhibitors, Graft survival, Liver Transplantation, Primary Biliary Cholangitis, Survival, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background & Aims: Tacrolimus has been associated with recurrence of primary biliary cholangitis (PBC) after liver transplantation (LT), which in turn may reduce survival. This study aimed to assess the association between the type of calcineurin inhibitor used and long-term outcomes following LT in patients with PBC. Methods: Survival analyses were used to assess the association between immunosuppressive drugs and graft or patient survival among adult patients with PBC in the European Liver Transplant Registry. Patients who received a donation after brain death graft between 1990 and 2021 with at least 1 year of event-free follow-up were included. Results: In total, 3,175 patients with PBC were followed for a median duration of 11.4 years (IQR 5.9–17.9) after LT. Tacrolimus (Tac) was registered in 2,056 (64.8%) and cyclosporin in 819 (25.8%) patients. Following adjustment for recipient age, recipient sex, donor age, and year of LT, Tac was not associated with higher risk of graft loss (adjusted hazard ratio [aHR] 1.07, 95% CI 0.92-1.25, p = 0.402) or death (aHR 1.06, 95% CI 0.90-1.24, p = 0.473) over cyclosporin. In this model, maintenance mycophenolate mofetil (MMF) was associated with a lower risk of graft loss (aHR 0.72, 95% CI 0.60-0.87, p

Published
2024
Full Text
View/download PDF

2. Branched chain amino acids are associated with metabolic complications in liver transplant recipients

Author

Marco Böhler, Eline H. van den Berg, Maria C.T. Almanza, Margery A. Connelly, Stephan J.L. Bakker, Vincent E. de Meijer, Robin P.F. Dullaart, Hans Blokzijl, E. Hak, B.G. Hepkema, F. Klont, T.J. Knobbe, D. Kremer, H.G.D. Leuvenink, W.S. Lexmond, H.G.M. Niesters, L.J. van Pelt, R.A. Pol, R.J. Porte, A.V. Ranchor, J.S.F. Sanders, M.J. Siebelink, R.J.H.J.A. Slart, J.C. Swarte, D.J. Touw, M.C. van den Heuvel, C. van Leer-Buter, M. van Londen, E.A.M. Verschuuren, M.J. Vos, R.K. Weersma, Faculteit Medische Wetenschappen/UMCG, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Groningen Research Institute of Pharmacy, University of Groningen, PharmacoTherapy, -Epidemiology and -Economics, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Health Psychology Research (HPR), Cardiovascular Centre (CVC), Translational Immunology Groningen (TRIGR), Pharmaceutical Analysis, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Groningen Research Institute for Asthma and COPD (GRIAC), Medicinal Chemistry and Bioanalysis (MCB), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
Sirolimus, Liver transplantation, Clinical Biochemistry, Branched chain amino acids, Type 2 diabetes, General Medicine, Metabolic syndrome, Cohort Studies, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Dyslipidemia, Risk Factors, Humans, Amino Acids, Branched-Chain
Abstract

BACKGROUND: Obesity, dyslipidemia and type 2 diabetes (T2D) contribute substantially to increased cardiovascular morbidity and mortality in patients after orthotopic liver transplantation (OLTx). Elevated plasma branched chain amino acids (BCAA) are linked to metabolic disturbances and cardiovascular disease (CVD) risk profiles in several non-OLTx populations.METHODS: Cross-sectional analysis of liver transplant recipients from TransplantLines, a single-center biobank and cohort study. BCAA plasma levels were measured by means of nuclear-magnetic resonance spectroscopy. CVD and cardiometabolic factors were collected by using data from electronic patient records. Associations were determined between BCAA plasma levels and T2D, Metabolic Syndrome (MetS), CVD as well as mTOR inhibition in liver transplant recipients.RESULTS: 336 Patients were divided into sex-stratified tertiles of total BCAA. MetS (PCONCLUSION: Elevated BCAA plasma levels are associated with T2D, MetS and use of Sirolimus in liver transplant recipients. BCAA plasma levels may represent a valuable biomarker for cardiometabolic complications after OLTx.

Published
2022

3. Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma: Is Neo-Adjuvant Chemo-Radiation Therapy Really Necessary? An International, Multicenter Comparison

Author

F.J. Hoogwater, H. Kuipers, V.E. de Meijer, C. Maulat, F. Muscari, W.G. Polak, B. van Hoek, C. Jézéquel, I.P. Alwayn, J.N. IJzermans, K. Mohkam, J.-Y. Mabrut, F.G. van Vilsteren, J.-P. Adam, L. Chiche, A. Chebaro, E. Boleslawski, J. Dubbeld, S. Darwish Murad, M. Rayar, and R.J. Porte

Subjects
Hepatology, Gastroenterology
Published
2022

6. Contents Vol. 26, 2009

Author

S.J. Cho, Hiroya Kuroyanagi, J.S. Lee, Jeon-Woo Park, Norihiro Kokudo, Shigeyuki Ueshima, R.J. Porte, Liu Qingguang, M.J. Kim, I.J. Choi, Takashi Akiyoshi, Yao Yingmin, Tomohiro Yamaguchi, Masatoshi Oya, Yoshihiro Moriya, Yoshiya Fujimoto, H. Vuilleumier, Seiichiro Yamamoto, S.R. Park, Masashi Ueno, Makoto Seki, Masatoshi Makuuchi, Qiang Zhu, Y.W. Kim, Shin Fujita, Weiliam Chen, Takeshi Omori, Akio Saiura, Christine A. Falabella, S.E. Lee, Zheng Xin, M.C. Kook, Junichi Kaneko, Tsuyoshi Konishi, V.B. Nieuwenhuijs, G.J. Barritt, Toshiharu Yamaguchi, B.H. Nam, Jiyong Liu, J.Y. Lee, Yasuhiko Sugawara, Takashi Abe, Toshirou Nishida, Masaaki Nakahara, Takayuki Akasu, C.G. Kim, M. Hübner, Hyun-Dong Chae, Rintaro Koga, A. Morphett, J.H. Lee, K.W. Ryu, Sumihito Tamura, Chongmei Yang, Nishida Toshirou, R.T.A. Padbury, K. Goossens, J. Peters, Masayuki Tori, Levent Filik, Junichi Togashi, Tsukasa Oyama, and Hiroki Akamatsu

Subjects
Traditional medicine, business.industry, Gastroenterology, Medicine, Surgery, business
Published
2009

9. Intraoperative pulmonary embolism and intracardiac thrombosis complicating liver transplantation: a systematic review

Author

N. WARNAAR, I.Q. MOLENAAR, S.D. COLQUHOUN, M.J.H. SLOOFF, S. SHERWANI, A.M. De WOLF, R.J. PORTE, and Groningen Institute for Organ Transplantation (GIOT)

Subjects
PRIMARY BILIARY-CIRRHOSIS, pulmonary embolism, liver transplantation, CARDIOPULMONARY BYPASS, COAGULATION, Hematology, ANTIFIBRINOLYTIC DRUGS, thromboembolic complication, intracardiac thrombosis, THROMBOEMBOLISM, parasitic diseases, FACTOR-V-LEIDEN, FIBRINOLYSIS, CARDIOVASCULAR COLLAPSE, SUDDEN PEROPERATIVE DEATH, TISSUE-PLASMINOGEN ACTIVATOR, antifibrinolytics
Abstract

Background: Pulmonary embolism (PE) and intracardiac thrombosis (ICT) are rare but potentially lethal complications during orthotopic liver transplantation (OLT). Methods: We aimed to review clinical and pathological correlates of PE and ICT in patients undergoing OLT. A systematic review of the literature was conducted using MEDLINE and ISI Web of Science. Results: Seventy-four cases of intraoperative PE and/or ICT were identified; PE alone in 32 patients (43%) and a combination of PE and ICT in 42 patients (57%). Most frequent clinical symptoms included systemic hypotension and concomitant rising pulmonary artery pressure, often leading to complete circulatory collapse. PE and ICT occurred in every stage of the operation and were reported equally in patients with or without the use of venovenous bypass or antifibrinolytics. A large variety of putative risk factors have been suggested in the literature, including the use of pulmonary artery catheters or certain blood products. Nineteen patients underwent urgent thrombectomy or thrombolysis. Overall mortality was 68% (50/74) and 41 patients (82%) died intraoperatively. Conclusion: Mortality was significantly higher in patients with an isolated PE, compared to patients with a combination of PE and ICT (91% and 50%, respectively; P

Published
2008

10. Subject Index Vol. 26, 2009

Author

Sumihito Tamura, Chongmei Yang, Liu Qingguang, Takeshi Omori, Yoshihiro Moriya, Yao Yingmin, Qiang Zhu, Yoshiya Fujimoto, M.C. Kook, Toshirou Nishida, C.G. Kim, S.R. Park, S.E. Lee, M. Hübner, Norihiro Kokudo, Toshiharu Yamaguchi, Takashi Akiyoshi, S.J. Cho, K.W. Ryu, Rintaro Koga, Masashi Ueno, Hiroya Kuroyanagi, J.S. Lee, Hyun-Dong Chae, J. Peters, Seiichiro Yamamoto, K. Goossens, Y.W. Kim, A. Morphett, Akio Saiura, Weiliam Chen, Hiroki Akamatsu, M.J. Kim, Masayuki Tori, Zheng Xin, Masatoshi Oya, H. Vuilleumier, B.H. Nam, Jiyong Liu, R.J. Porte, I.J. Choi, Junichi Kaneko, Nishida Toshirou, Yasuhiko Sugawara, Jeon-Woo Park, J.H. Lee, V.B. Nieuwenhuijs, Christine A. Falabella, Shigeyuki Ueshima, Masaaki Nakahara, Tsukasa Oyama, Takashi Abe, Takayuki Akasu, R.T.A. Padbury, Tomohiro Yamaguchi, Junichi Togashi, Makoto Seki, Masatoshi Makuuchi, Tsuyoshi Konishi, J.Y. Lee, Shin Fujita, G.J. Barritt, and Levent Filik

Subjects
medicine.medical_specialty, Index (economics), business.industry, Internal medicine, Gastroenterology, medicine, Surgery, Subject (documents), Medical physics, business
Published
2009

Catalog

Books, media, physical & digital resources
See catalog results