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Morinda citrifolia juice has long been used as a traditional herbal medicine in Indonesia to treat various diseases, including lowering blood sugar levels. However, the compounds responsible for this activity have not been widely studied. This research aimed to isolate the marker compounds from fermented M. citrifolia juice extract based on bioassay guidelines of antidiabetic activity and reduction of DPPH. Separation and purification of the ethyl acetate fraction yielded two, namely compounds 1 and 2. The chemical structures of these marker compounds, identified as scopoletin (1) and quercetin (2), were elucidated by LCMS Spectrometry and NMR analyses. The IC50 values of compounds 1 and 2 were respectively 61.93 and 21.65 μM for α-glucosidase, with 844.06 and 35.23 μM for DPPH free radical scavenger effect. Based on these results, scopoletin and quercetin can be used as quality control biomarkers of products produced from fermented M. citrifolia juice extract.

The aim of this study was to determine the effect of Cirripedia sp. flour as a fish flour substitution on body weight gain, feed conversion ratio and feed consumption of the rabbit. The experimental design used was 4 treatments and 5 replication each. This research were 100 Rex buck aged 4 months. The feed treatments used were P0 (complete feed 100% with 15% fish flour), P1(complete feed 100% with 12.5% fish flour and 2.5% Cirripedia sp. flour), P2 (complete feed 100% with 10% fish flour and 5% Cirripedia sp. flour), P3 (complete feed 100% with 7.5% fish flour and 7.5% Cirripedia sp. flour). The data were recorded at the fourth week after observation based on feed consumption, body weight gain, and feed conversion ratio. Data were analyzed with ANOVA (Analysis of Variance). Average feed consumption of P0 to P3 were 114,54, 112,09, 114,04, 112,71 g. Average of body weight gain of P0 to P3 were 20,01, 20,87, 20,72 and 20,75g. Average of feed conversion ratio of P0 to P3 were 5,79, 5,41, 5,62 and 5,48. The result showed with no significant difference (p>0.05) among the treatment in feed consumption, body weight gain, and feed conversion ratio in the rabbit.

Introduction Vitamin D deficiency and anemia are examples of nutritional problems of global health significance. When these health issues effect pregnant women, they may become a threat to the fetus' potention for intrauterine growth. It has been known that the first trimester is the golden period of fetal programming which influences the fetuses and their life after birth. This study was aiming to analyze the association between first trimester maternal vitamin D, serum ferritin, hemoglobin level and neonatal birth weight. Methods From July 2016 a prospective cohort of pregnant women had been observed in four cities in West Java, Indonesia. Two hundred ninety four pregnant women were recuited in the first trimester and 203 of them had complete follow up until delivery. Collected data included maternal demography, blood analysis for ferritin, 25(OH) vitamin D in the first trimester of pregnancy and the birth weight of neonates. Associations were analyzed with multiple regression models. Results Vitamin D deficiency was highly prevalent among pregnant women in this study (approximately 75%) while anemia was found in 7.5 %, a little above the target of 5 %. However, no significant association was found between maternal serum vitamin D, serum ferritin, hemoglobin level in the first trimester and birth weight of the neonates, before and after adjustment for maternal age, pre-pregnancy body mass index, and parity. Conclusion There were no associations found between vitamin D, ferritin, and hemoglobin level in the first trimester and neonatal birth weight. The negative results in this study should not diminish the benefit of nutritional supplementation during pregnancy. The possibility of other explanatory variables that influence these associations warrants further studies.