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ZusammenfassungDas Essay deutet die Gestalt des Ödipus und sein Schicksal nach modernen medizinisch-wissenschaftlichen Kriterien. Die Misshandlungen, die das Kleinkind erlitt, bekommen dabei als auslösender Faktor einen besonders Stellenwert. Der Name „Ödipus“, üblicherweise mit „Schwellfuß“ übersetzt, wird hinsichtlich seines etymologischen Ursprungs untersucht, sodass verschiedene Schlüsse aus dem Namen gezogen werden können, auch die, dass es dem Heroen leicht gefallen sein muss, das Rätsel der Sphinx zu lösen, da es mit der Funktion der Füße eine orthopädische Kernaussage hatte. Es können bei Ödipus mehrere Verletzungen und Störungen diagnostiziert und nach dem aktuellen ICD-Schlüssel klassifiziert werden, z. B. die Blindheit, nachdem er sich selbst geblendet hatte. Zudem ergibt sich der Verdacht auf das Vorliegen einer posttraumatischen Belastungsstörung sowie einer Borderline-Persönlichkeitsstörung, die sich einstellten, nachdem Ödipus von seinen Eltern misshandelt wurde, um ihn zu töten. Damit wird auch die Frage nach seiner Schuld an den von ihm begangenen Taten neu hinterfragt. Die Geschichte des „Ödipus“ bestätigt die Lebenswirklichkeit griechischer Mythologie aufs Neue.

AbstractCantharidin, an inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), is known to increase the force of contraction and shorten the time to relaxation in human ventricular preparations. We hypothesized that cantharidin has similar positive inotropic effects in human right atrial appendage (RAA) preparations. RAA were obtained during bypass surgery performed on human patients. These trabeculae were mounted in organ baths and electrically stimulated at 1 Hz. For comparison, we studied isolated electrically stimulated left atrial (LA) preparations and isolated spontaneously beating right atrial (RA) preparations from wild-type mice. Cumulatively applied (starting at 10 to 30 µM), cantharidin exerted a positive concentration-dependent inotropic effect that plateaued at 300 µM in the RAA, LA, and RA preparations. This positive inotropic effect was accompanied by a shortening of the time to relaxation in human atrial preparations (HAPs). Notably, cantharidin did not alter the beating rate in the RA preparations. Furthermore, cantharidin (100 µM) increased the phosphorylation state of phospholamban and the inhibitory subunit of troponin I in RAA preparations, which may account for the faster relaxation observed. The generated data indicate that PP1 and/or PP2A play a functional role in human atrial contractility.

Field studies were conducted in North Carolina in 2018 and 2019 to determine sweetpotato tolerance to indaziflam and its effectiveness in controlling Palmer amaranth in sweetpotato. Treatments included indaziflam pre-transplant; 7 d after transplanting (DATr) or 14 DATr at 29, 44, 58, or 73 g ai ha−1; and checks (weedy and weed-free). Indaziflam applied postemergence caused transient foliar injury to sweetpotato. Indaziflam pretransplant caused less injury to sweetpotato than other application timings regardless of rate. Palmer amaranth control was greatest when indaziflam was applied pretransplant or 7 DATr. In a weed-free environment, sweetpotato marketable yield decreased as indaziflam application was delayed. No differences in storage root length to width ratio were observed.

Field studies were conducted in North Carolina in 2019 and 2020 to determine the effect of a reduced-tillage, high-residue rye (Secale cereal) cover crop system on soil health, and growth and storage root yield of sweetpotato (Ipomoea batatas) cultivars having upright (NC04-0531 or NC15-650) or prostrate (Covington or Bayou Belle) vining characteristics. Sweetpotato canopy width expanded quicker in the conventional tillage system than the reduced-tillage rye system. Prostrate sweetpotato cultivars had greater late-season canopy widths than upright cultivars. Soil bulk density of raised beds was greatest in the reduced-tillage rye system, but both systems remained within the U.S. Department of Agriculture recommended range for soil bulk density. The conventional-tillage system resulted in 17% more marketable roots; however, no differences were observed in total marketable root weight between systems. ‘Covington’ and ‘NC15-650’ had greater marketable yield than ‘NC04-0531’ but less marketable yield than ‘Bayou Belle’.

KCNQ1 voltage-gated K+ channels are involved in a wide variety of fundamental physiological processes and exhibit the unique feature of being markedly inhibited by external K+. Despite the potential role of this regulatory mechanism in distinct physiological and pathological processes, its exact underpinnings are not well understood. In this study, using extensive mutagenesis, molecular dynamics simulations, and single-channel recordings, we delineate the molecular mechanism of KCNQ1 modulation by external K+. First, we demonstrate the involvement of the selectivity filter in the external K+ sensitivity of the channel. Then, we show that external K+ binds to the vacant outermost ion coordination site of the selectivity filter inducing a diminution in the unitary conductance of the channel. The larger reduction in the unitary conductance compared to whole-cell currents suggests an additional modulatory effect of external K+ on the channel. Further, we show that the external K+ sensitivity of the heteromeric KCNQ1/KCNE complexes depends on the type of associated KCNE subunits.

The Orbiting Astronomical Satellite for Investigating Stellar Systems (OASIS) is a NASA Astrophysics MIDEX-class mission concept, with the stated goal of following water from galaxies, through protostellar systems, to Earth's oceans. This paper details the protoplanetary disk science achievable with OASIS. OASIS's suite of heterodyne receivers allow for simultaneous, high spectral resolution observations of water emission lines spanning a large range of physical conditions within protoplanetary disks. These observations will allow us to map the spatial distribution of water vapor in disks across evolutionary stages and assess the importance of water, particularly the location of the midplane water snowline, to planet formation. OASIS will also detect the H2 isotopologue HD in 100+ disks, allowing for the most accurate determination of total protoplanetary disk gas mass to date. When combined with the contemporaneous water observations, the HD detection will also allow us to trace the evolution of water vapor across evolutionary stages. These observations will enable OASIS to characterize the time development of the water distribution and the role water plays in the process of planetary system formation., 19 pages, 5 figures, published in Space Science Reviews

Cantharidin, an inhibitor of protein phosphatases 1 and 2A (PP1, PP2A), is known to increase force of contraction and to shorten time of relaxation in human ventricular preparations. We hypothesized that cantharidin has similar positive inotropic effects in human atrial preparations (HAP). During bypass-surgery trabeculae carneae from human right atrium were obtained. These trabeculae were mounted in organ baths and electrically stimulated (1 Hz). For comparison, we studied isolated electrically stimulated left atrial preparations (LA) and isolated spontaneously beating right atrial preparations (RA) from wild type mice. We noted a concentration-dependent positive inotropic effect of cantharidin, cumulatively applied, starting at 10 µM to 30 µM that reached a plateau at 300 µM in HAP, LA and RA. This positive inotropic effect was accompanied by a shortening of time of relaxation in HAP. Notably, cantharidin did not alter the beating rate in RA. Moreover, cantharidin (100 µM) increased the phosphorylation state of phospholamban and the inhibitory subunit of troponin I in HAP that could account for the faster relaxation, that we had measured. The present data suggest a functional role for PP1 and/or PP2A in human atrial contractility.

In myelinated nerve fibers, action potentials are generated at nodes of Ranvier. These structures are located at interruptions of the myelin sheath, forming narrow gaps with small rings of axolemma freely exposed to the extracellular space. The mammalian node contains a high density of Na channels and K-selective leakage channels. Voltage-dependent Kv1 channels are only present in the juxta-paranode. Recently, the leakage channels have been identified as K2P channels (TRAAK, TREK-1). K2P channels are K-selective "background" channels, characterized by outward rectification and their ability to be activated, e.g. by temperature, mechanical stretch, or arachidonic acid. We are only beginning to elucidate the peculiar functions of nodal K2P channels. I will discuss two functions of the nodal K2P-mediated conductance. First, at body temperature K2P channels have a high open probability, thereby inducing a resting potential of about -85 mV. This negative resting potential reduces steady-state Na channel inactivation and ensures a large Na inward current upon a depolarizing stimulus. Second, the involvement of the K2P conductance in nodal action potential repolarization. The identification of nodal K2P channels is exciting since it shows that the nodal K conductance is not a fixed value but can be changed, it can be increased or decreased by a broad range of K2P modulators, thereby modulating e.g. the resting potential. I will exemplify the functional importance of nodal K2P channels by describing in more detail the function of the K2P conductance increase by increasing the temperature to 37°C. This article is protected by copyright. All rights reserved.

This essay studies the physical shape, character and fate of Oedipus, applying relevant and current medical scientific criteria. The abuses he suffered during childhood play an important role in this context. The name Oedipus is usually translated as "swollen foot", but according to various etymological sources, the name can be interpreted in different ways. One of these interpretations alludes to fact that it was easy for the hero to solve the riddle of the sphinx because its key message addressed an orthopedic issue as it was dealing with the function of the feet. During Oedipus' life, he suffered many injuries and disorders, which can be classified using the current ICD code. There is, for example, his blindness after he had blinded himself. In addition, we can assume that Oedipus suffered from a post-traumatic stress disorder and a borderline personality disorder following the child abuse caused by his parents who intended to kill him. Thus, the discussion about his own responsibility for his actions is again being put into question. Oedipus`s life story is once again proof that Greek mythology can reflect the reality of life.Das Essay deutet die Gestalt des Ödipus und sein Schicksal nach modernen medizinisch-wissenschaftlichen Kriterien. Die Misshandlungen, die das Kleinkind erlitt, bekommen dabei als auslösender Faktor einen besonders Stellenwert. Der Name „Ödipus“, üblicherweise mit „Schwellfuß“ übersetzt, wird hinsichtlich seines etymologischen Ursprungs untersucht, sodass verschiedene Schlüsse aus dem Namen gezogen werden können, auch die, dass es dem Heroen leicht gefallen sein muss, das Rätsel der Sphinx zu lösen, da es mit der Funktion der Füße eine orthopädische Kernaussage hatte. Es können bei Ödipus mehrere Verletzungen und Störungen diagnostiziert und nach dem aktuellen ICD-Schlüssel klassifiziert werden, z. B. die Blindheit, nachdem er sich selbst geblendet hatte. Zudem ergibt sich der Verdacht auf das Vorliegen einer posttraumatischen Belastungsstörung sowie einer Borderline-Persönlichkeitsstörung, die sich einstellten, nachdem Ödipus von seinen Eltern misshandelt wurde, um ihn zu töten. Damit wird auch die Frage nach seiner Schuld an den von ihm begangenen Taten neu hinterfragt. Die Geschichte des „Ödipus“ bestätigt die Lebenswirklichkeit griechischer Mythologie aufs Neue.

Constraining planet formation based on the atmospheric composition of exoplanets is a fundamental goal of the exoplanet community. Existing studies commonly try to constrain atmospheric abundances, or to analyze what abundance patterns a given description of planet formation predicts. However, there is also a pressing need to develop methodologies that investigate how to transform atmospheric compositions into planetary formation inferences. In this study we summarize the complexities and uncertainties of state-of-the-art planet formation models and how they influence planetary atmospheric compositions. We introduce a methodology that explores the effect of different formation model assumptions when interpreting atmospheric compositions. We apply this framework to the directly imaged planet HR 8799e. Based on its atmospheric composition, this planet may have migrated significantly during its formation. We show that including the chemical evolution of the protoplanetary disk leads to a reduced need for migration. Moreover, we find that pebble accretion can reproduce the planet's composition, but some of our tested setups lead to too low atmospheric metallicities, even when considering that evaporating pebbles may enrich the disk gas. We conclude that the definitive inversion from atmospheric abundances to planet formation for a given planet may be challenging, but a qualitative understanding of the effects of different formation models is possible, opening up pathways for new investigations., Accepted for publication in ApJ, base formation inversion code is available at: https://gitlab.com/mauricemolli/formation-inversion

West Nile virus (WNV) neuroinvasive disease threatens the health and well-being of horses and humans worldwide. Disease in horses and humans is remarkably similar. The occurrence of WNV disease in these mammalian hosts has geographic overlap with shared macroscale and microscale drivers of risk. Importantly, intrahost virus dynamics, the evolution of the antibody response, and clinicopathology are similar. The goal of this review is to provide a comparison of WNV infection in humans and horses and to identify similarities that can be exploited to enhance surveillance methods for the early detection of WNV neuroinvasive disease.

High spatial resolution observations of CO isotopologue line emission in protoplanetary disks at mid-inclinations (${\approx}$30-75{\deg}) allow us to characterize the gas structure in detail, including radial and vertical substructures, emission surface heights and their dependencies on source characteristics, and disk temperature profiles. By combining observations of a suite of CO isotopologues, we can map the 2D (r, z) disk structure from the disk upper atmosphere, as traced by CO, to near the midplane, as probed by less abundant isotopologues. Here, we present high angular resolution (${\lesssim}$0."1 to ${\approx}$0."2; ${\approx}$15-30 au) observations of CO, $^{13}$CO, and C$^{18}$O in either or both J=2-1 and J=3-2 lines in the transition disks around DM Tau, Sz 91, LkCa 15, and HD 34282. We derived line emission surfaces in CO for all disks and in $^{13}$CO for the DM Tau and LkCa 15 disks. With these observations, we do not resolve the vertical structure of C$^{18}$O in any disk, which is instead consistent with C$^{18}$O emission originating from the midplane. Both the J=2-1 and J=3-2 lines show similar heights. Using the derived emission surfaces, we computed radial and vertical gas temperature distributions for each disk, including empirical temperature models for the DM Tau and LkCa 15 disks. After combining our sample with literature sources, we find that $^{13}$CO line emitting heights are also tentatively linked with source characteristics, e.g., stellar host mass, gas temperature, disk size, and show steeper trends than seen in CO emission surfaces., Comment: 31 pages, 15 figures, accepted for publication in ApJ. Image cubes available at https://zenodo.org/record/7430257

Dynamic microtubules transiently polymerize into dendritic spines, however intracellular factors that regulate this process and their functional role at synapses are hardly understood. Using live imaging, electrophysiology, and glutamate uncaging, we show that the microtubule-severing complex katanin is located at individual spine synapses, participates in the activity-dependent process of microtubule polymerization into dendritic spines, and regulates synaptic plasticity. Overexpression of a dominant-negative ATPase-deficient katanin subunit, did not alter microtubule growth velocities or comet density in dendrites, but significantly reduced the activity-dependent invasion of microtubules into dendritic spines. Notably, functional inhibition of katanin significantly affected the potentiation of AMPA-receptor-mediated excitatory currents after chemical induction of long-term potentiation (cLTP). Furthermore, interference with katanin function prevented structural spine remodeling following single spine glutamate uncaging. Our data identify katanin at individual spine synapses in association with PSD-95. Thus, katanin regulates postsynaptic microtubules and modulates synaptic structure and function.

We report on the design and performance of the Bicep3 instrument and its first three-year data set collected from 2016 to 2018. Bicep3 is a 52 cm aperture refracting telescope designed to observe the polarization of the cosmic microwave background (CMB) on degree angular scales at 95 GHz. It started science observation at the South Pole in 2016 with 2400 antenna-coupled transition-edge sensor bolometers. The receiver first demonstrated new technologies such as large-diameter alumina optics, Zotefoam infrared filters, and flux-activated SQUIDs, allowing ∼10× higher optical throughput compared to the Keck design. Bicep3 achieved instrument noise equivalent temperatures of 9.2, 6.8, and 7.1 μ K CMB s and reached Stokes Q and U map depths of 5.9, 4.4, and 4.4 μK arcmin in 2016, 2017, and 2018, respectively. The combined three-year data set achieved a polarization map depth of 2.8 μK arcmin over an effective area of 585 square degrees, which is the deepest CMB polarization map made to date at 95 GHz.