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Executive attention is involved in working memory; however, the role of executive attention in the maintenance of information in spatial working memory is debated. This study examined whether inhibitory control was related to spatial working memory biases in adults in a simple spatial memory task where participants had to remember one location on an otherwise blank computer screen. On some trials, a distractor was presented during the maintenance period. Eighty-four participants completed the spatial working memory task and a battery of cognitive control measures. When a distractor was presented during the maintenance period of the spatial memory task, performance on two of the cognitive control measures, a measure of overall attention and a measure of inhibitory control was related to memory errors. When a distractor was not presented during the spatial memory task, memory errors were not related to performance on the cognitive control tasks. Overall, these effects demonstrated that attention is related to maintaining locations in spatial working memory in adults, and inhibitory control may also be related such that those with more efficient inhibitory control were less influenced by distractors presented during the maintenance period.

A growing body of research has found a relationship between parenting and the development of executive function in young children ; however, fewer studies have examined how parenting is related spe...

Objective:\ud \ud There is increasing evidence that red and processed meat consumption is associated with increased risk of cardiovascular (CV) disease. However, little literature reported the association among people with obesity versus those without obesity. We sought to investigate this using the UK Biobank data.\ud \ud Methods:\ud \ud In this large prospective population-based cohort study, the red and processed meat consumption was assessed through the UK Biobank touch-screen questionnaire at baseline. The estimated hazards ratios (HRs) with 95% confidence intervals (CIs) were obtained from the Cox proportional hazard models to assess the association between red and processed meat consumption and the risk of CV death, cerebrovascular, and ischemic heart diseases in participants with and without obesity.\ud \ud Results:\ud \ud Of 428,070 participants, 100,175 (23.4%) were obese with the mean age of 56 (SD: 7.9) years old and 54% were female. Participants without obesity, the mean age was 56 (SD: 5.2) years old and 55% were female. The overall median follow-up was 7.2 (IQR: 6.5–7.8) years. red and processed meat consumption had increased risk of CV death (HR (95%CI):1.04 (1.01–1.08) per week serve for participants with obesity and 1.04 (1.02–1.07) for those without obesity) after adjusted for age, sex, ethnicity, education, smoking and alcohol status and overall health. The moderate positive association between red and processed meat consumption and ischemic heart disease was only observed in participants without obesity (HR (95%CI): 1.15 (1.00–1.31) for the highest versus lowest terciles of red and processed meat consumption). No association was found with cerebrovascular disease in the participants regardless of obesity.\ud \ud Conclusions:\ud \ud Consumption frequency of red and processed meat is associated with higher risk of CV death regardless of obesity. The risk of ischemic heart disease associated with red and processed meat consumption may be higher in participants without obesity. Further studies are needed to understand the full extent of the mechanism of the association.

Background Excessive alcohol use is the third leading cause of mortality in the United States, where alcohol use consistently increased over the last decades. This trend is currently maintained, despite regulatory policies aimed to counteract it. While the increased health risks resulting from alcohol use are evident, some open questions regarding alcohol use and its consequences in the US population remain. Objectives The current work aims to evaluate the relation between alcohol consumption trends over a period of 15 y with all-cause and cause-specific mortality. In addition, we evaluate the adequacy of the current alcohol recommended limits according to the 2015-2020 US Dietary Guidelines for Americans (USDGA). Methods This was a prospective population-based study defined by the NHANES conducted over the period 1999-2014 linked to US mortality registry in 2015. Results The sample, composed of 34,672 participants, was observed for a median period of 7.8 y, totaling 282,855 person-years. In the present sample, 4,303 deaths were observed. Alcohol use increased during the period 1999-2014. Alcohol use above the current US recommendations was associated with increased all-cause and cause-specific mortality risk, ranging from 39% to 126%. A proportion of these deaths, ranging from 19% to 26%, could be theoretically prevented if US citizens followed current guidelines, and 13% of all-cause deaths in men could be avoided if the current US guidelines for women (1 standard drink/d) were applied to them. Conclusions The present study provides evidence in support of limiting alcohol intake in adherence to the USDGA recommendations.

Blood groups might influence susceptibility to COVID-19 [1-7]. We investigated associations between blood groups and COVID-19 infection in UK Biobank participants, a prospective population-based study that, between 2006 and 2010, enrolled 502,620 people aged 38-73 years in the United Kingdom. All participants gave written informed consent for their data to be used for research purposes, which was also approved by an ethics committee.

Summary Background & aims Uncertainty still exists on the impact of low to moderate consumption of different drink types on population health. We therefore investigated the associations of different drink types in the form of beer/cider, champagne/white wine, red wine and spirits with various health outcomes. Methods Over 500,000 participants were recruited to the UK Biobank cohort. Alcohol consumption was self-reported as pints beer/cider, glasses champagne/white wine, glasses of red wine, and measures of spirits per week. We followed health outcomes for a median of 7.02 years and reported all-cause mortality, cardiovascular events, ischemic heart disease, cerebrovascular events, and cancer. Results In continuous analysis after excluding non-drinkers, beer/cider and spirits intake associated with an increased risk for all-cause mortality (beer/cider: hazard ratio, 1.56; 95% confidence interval, 1.45–1.68; spirits: 1.47; 1.35–1.60), cardiovascular events (beer/cider: 1.25; 1.17–1.33; spirits: 1.25; 1.16–1.36), ischemic heart disease (beer/cider:1.12; 0.99–1.26 [P = 0.056]; spirits: 1.17; 1.02–1.35), cerebrovascular disease (beer/cider: 1.63; 1.32–2.02; spirits: 1.59; 1.25–2.02) and cancer (beer/cider: 1.14; 1.05–1.24; spirits: 1.14; 1.03–1.26), while both champagne/white wine and red wine associated with a decreased risk for ischemic heart disease only (champagne/white wine: 0.84; 0.72–0.98; red wine: 0.88; 0.77–0.99). Conclusions Our findings do not support the notion that alcohol from any drink type is beneficial to health. Consuming low levels of beer/cider and spirits already associated with an increased risk for all health outcomes, while wine showed opposite protective relationships only with ischemic heart disease.

Background Despite several muscle mass measures being used in the current definitions of sarcopenia, their usefulness is uncertain because of limited data on their association with health outcomes. The aim of the study was to compare the performance of different muscle mass measures for predicting incident osteoporosis in postmenopausal women. Methods This study included data from 149 166 participants (aged 60.3 ± 5.5 years) as part of the UK Biobank cohort. Body composition was assessed using bioelectrical impedance. The muscle mass measures included were total body skeletal muscle mass (SMM) and appendicular SMM (aSMM) divided by height squared (ht2), derived residuals, SMM, SMM adjusted for body mass (SMM/bm × 100), and aSMM normalized for body mass index (aSMM/BMI). Diagnoses of the events were confirmed by primary care physicians and coded according to the World Health Organization's International Classification of Diseases 10th Revision (ICD‐10: M80‐M82). Results Over a median follow‐up of 6.75 (5th to 95th percentile interval, 1.53 to 8.37) years, 394 newly diagnosed cases of osteoporosis occurred, with 40 (10.2%) cases being associated with a pathological fracture. SMM/ht2, aSMM/ht2 residual, and SMM were lower in postmenopausal women with osteoporosis compared with women without (all P

In the conversion of ionizing radiation into energy, the production of heat is the most common first step in energy conversion systems, but it is also possible to use ions and excited states as the first step. The difference being that nearly all of the energy content of ionizing radiation is converted to heat but only 40–50% of the energy content of ionizing radiation is converted into ions and excited states. Conversion of the energy contained in ionizing radiation into ions and excited states starts out at a considerable disadvantage. Nuclear-pumped lasers have typically depended on the conversion of ionizing radiation into ions and excited states as a first step. Among the reasons that nuclear-pumped lasers have had low system efficiencies (1–2.5%) is the considerable inefficiencies in producing ions and excited states from ionizing radiation. A nuclear-pumped laser system which uses heat produced from the energy content of ionizing radiation as the driver for the laser system is described in this paper. The conversion of heat into vibrational states in molecular nitrogen allows energy to be stored in a long lived molecular state which can then be transported spatially where its energy is collisionally conveyed to carbon dioxide molecules in a resonance transfer process to produce the carbon dioxide upper laser level. The carbon dioxide laser emits a laser beam with a wavelength centered at 10.4 μm. The nitrogen vibrational state and its resonance conversion into the carbon dioxide upper laser level is one of nature's most efficient processes in laser physics (with laser efficiencies approaching ∼20% primarily being driven by the resonance process-extremely high for a laser). The laser system described here takes advantage of this highly efficient mechanism for conversion of thermal energy to optical energy. The feasibility of using nuclear rocket core technology for the generation of high temperature gas flows to power this thermal to optical conversion process is described. This study indicates that the thermal to optical conversion process can lead to a carbon dioxide laser with efficiencies on the order of 7% or perhaps better. Such a system would have potential applications in power beaming, space propulsion, asteroid mining, asteroid deflection and potential military applications.

Spatial working memory (SWM) and executive functions, including attention, inhibition and working memory, are important for children’s well-being, educational attainment, and social relationships ( Bull & Scerif, 2001 ; Posner, 2012 ; Riggs, Jahromi, Razza, Dillworth-Bart, & Mueller, 2006 ). The purpose of the current study is to examine the relationship between attention and inhibition, and a SWM task in 4–8-year-old children. The SWM task measured children’s ability to remember the location of a target on a blank screen both with and without a distractor present during the delay. We conducted a secondary data analysis of this task from two previous studies ( Beattie, 2014 ; Schutte, Torquati, & Beattie, 2017 ). Multilevel models showed that for younger children, faster reaction time on an attention task was related to errors in the SWM task that were more similar to older children. In addition, children whose parents indicated they had higher inhibitory control inhibited distractors more than other children. Overall, the findings demonstrate that children with greater attention and inhibition abilities also had greater SWM abilities.

Objectives Previous studies suggest that changes in body weight can lead to an increased risk of mortality in the general population, although the results are controversial. The current study sought to investigate this association further using data from the UK Biobank. Study design This is a large prospective population-based cohort study. Data were derived from the UK Biobank, with the initial assessments commencing between 2006 and 2010. Methods Proportional hazard models were used to assess the association between self-reported weight change and risk of all-cause, cancer and cardiovascular mortality. The effect of gender was also investigated. Results Of 433,829 participants with data for self-reported weight change, the mean age was 56 (standard deviation [SD]: 8.1) years and 55% were female. In total, 55% of participants reported no weight change, 28% gained weight, 15% lost weight, 2% did not know and 0.1% preferred not to give an answer. The median follow-up was 7.1 (interquartile range [IQR]: 6.4–7.8) years. Compared with participants with no weight change, those with weight loss had an increased risk of all-cause mortality (adjusted hazard ratio [HR] 1.25, 95% confident interval [CI] 1.18–1.32), cancer death (HR 1.17, 95% CI 1.08–1.27) and cardiovascular death (HR 1.26, 95% CI 1.12–1.43). Similarly, participants reporting weight gain also had an increased risk of all-cause mortality (HR 1.08, 95% CI 1.02–1.13), cancer death (HR 1.14, 95% CI 1.07–1.22) and cardiovascular death (HR 1.27, 95% CI 1.14–1.42). Participants who had a response ‘do not know’ or ‘prefer not to answer’ showed an increased risk of all-cause and cardiovascular mortality, particularly in men. Conclusions The results of this study highlight the importance of maintaining a stable weight in middle-aged adults. Further studies are needed to understand the pathophysiology of weight change and its effects on mortality.

CVD is the most common chronic condition and the highest cause of mortality in the USA. The aim of the present work was to investigate diet and sedentary behaviour in relation to mortality in US CVD survivors. The National Health and Nutrition Examination Surveys conducted between 1999 and 2014 linked to the US mortality registry updated to 2015 were investigated. Multivariate adjusted Cox regression was used to derive mortality hazards in relation to sedentary behaviour and nutrient intake. A multiplicative and additive interaction analysis was conducted to evaluate how sedentariness and diet influence mortality in US CVD survivors. A sample of 2473 participants followed for a median period of 5·6 years resulted in 761 deaths, and 199 deaths were due to CVD. A monotone increasing relationship between time spent in sedentary activities and mortality risk was observed for all-cause and CVD mortality (hazard ratio (HR) = 1·20, 95 % CI 1·09, 1·31 and HR = 1·19, 95 % CI 1·00, 1·67, respectively). Inverse mortality risks in the range of 22–34 % were observed when comparing the highest with the lowest tertile of dietary fibre, vitamin A, carotene, riboflavin and vitamin C. Sedentariness below 360 min/d and dietary fibre and vitamin intake above the median interact on an additive scale influencing positively all-cause and CVD mortality risk. Reduced sedentariness in combination with a varied diet rich in dietary fibre and vitamins appears to be a useful strategy to reduce all-cause and CVD mortality in US CVD survivors.

Consistent reports indicate that hypertension is a particularly common finding in black populations. Hypertension occurs at younger ages and is often more severe in terms of blood pressure levels and organ damage than in whites, resulting in a higher incidence of cardiovascular disease and mortality. This review provides an outline of recent advances in the pathophysiological understanding of blood pressure elevation and the consequences thereof in black populations in Africa. This is set against the backdrop of populations undergoing demanding and rapid demographic transition, where infection with the human immunodeficiency virus predominates, and where under and over-nutrition coexist. Collectively, recent findings from Africa illustrate an increased lifetime risk to hypertension from foetal life onwards. From young ages black populations display early endothelial dysfunction, increased vascular tone and reactivity, microvascular structural adaptions as well as increased aortic stiffness resulting in elevated central and brachial blood pressures during the day and night, when compared to whites. Together with knowledge on the contributions of sympathetic activation and abnormal renal sodium handling, these pathophysiological adaptations result in subclinical and clinical organ damage at younger ages. This overall enhanced understanding on the determinants of blood pressure elevation in blacks encourages (a) novel approaches to assess and manage hypertension in Africa better, (b) further scientific discovery to develop more effective prevention and treatment strategies and (c) policymakers and health advocates to collectively contribute in creating health-promoting environments in Africa.

Background Black populations exhibit lower concentrations of the cardioprotective peptide, insulin-like growth factor-1 (IGF-1), and are more prone to develop hypertensive heart disease than whites. We therefore determined whether lower IGF-1 in black individuals relates to a marker of cardiac overload and systolic dysfunction, namely N-terminal prohormone B-type natriuretic peptide (NT-proBNP). Materials and methods We included 160 black and 195 white non-diabetic South African men and women (aged 44.4 ± 9.81 years), and measured ambulatory blood pressure, NT-proBNP, IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3). Results Although the black group presented elevated ambulatory blood pressure accompanied by lower IGF-1 compared to the white group (all p

According to attention restoration theory, directed attention can become fatigued and then be restored by spending time in a restorative environment. This study examined the restorative effects of nature on children’s executive functioning. Seven- to 8-year-olds (school aged, n = 34) and 4- to 5-year-olds (preschool, n = 33) participated in two sessions in which they completed an activity to fatigue attention, then walked along urban streets (urban walk) in one session and in a park-like area (nature walk) in another session, and finally completed assessments of working memory, inhibitory control, and attention. Children responded faster on the attention task after a nature walk than an urban walk. School-aged children performed significantly better on the attention task than preschoolers following the nature walk, but not urban walk. Walk type did not affect inhibitory control or verbal working memory. However, preschoolers’ spatial working memory remained more stable following the nature walk than the urban walk.

Adverse changes in retinal microvasculature caliber are associated with incident hypertension, coronary heart disease and stroke. The absence of a nocturnal dipping in arterial pressure may induce changes throughout the vascular tree, including the retinal microvasculature, but the later link is not sufficiently studied. We explored the relationship between retinal vessel caliber and dipping status in a group of black and white teachers. The study included black (n=68) and white (n=81) men (24-66 years) from the SABPA study. We measured 24 h ambulatory blood pressure and the percentage mean arterial pressure dipping(%MAPdip) was calculated as (diurnal MAP-nocturnal MAP)/diurnal MAP × 100. Retinal images were captured and the central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) calculated. Black men demonstrated higher diurnal and nocturnal MAP (P⩽0.001) and a lesser %MAPdip compared with white men (P=0.047). When stratified by dipping status, black non-dippers (n=33) revealed an increased CRVE (P0.001) compared with their dipper counterparts (n=35). In black men, CRVE was negatively (R

This study examined whether attention to a location plays a role in the maintenance of locations in spatial working memory in young children as it does in adults. This study was the first to investigate whether distractors presented during the delay of a spatial working memory task influenced young children's memory responses. Across two experiments, 3- and 6-year-olds completed a spatial working memory task featuring a static target location and distractor location. Results indicated a change between 3 and 6 years of age in how distractors influenced memory. Six-year-olds' memory responses were biased away from a distractor that was close to the target location and on the outside of the target location relative to the center of the monitor. Distractors that were far from the target or that were toward the center of the monitor relative to the target location had no effect. Three-year-olds' responses were biased toward a distractor when the distractor was on the outside of the target location and farther from the target. Distractors that were near the target location or toward the center of the monitor had no effect. These biases provide evidence that young children's maintenance of a location in memory is influenced by attention.

BackgroundTo investigate associations between active transport, employment status and objectively measured moderate-to-vigorous physical activity (MVPA) in a representative sample of US adults.MethodsCross-sectional analyses of data from the National Health and Nutrition Examination Survey. A total of 5180 adults (50.2 years old, 49.0% men) were classified by levels of active transportation and employment status. Outcome measure was weekly time spent in MVPA as recorded by the Actigraph accelerometer. Associations between active transport, employment status and objectively measured MVPA were examined using multivariable linear regression models adjusted for age, body mass index, race and ethnicity, education level, marital status, smoking status, working hour duration (among the employed only) and self-reported leisure time physical activity.ResultsPatterns of active transport were similar between the employed (n=2897) and unemployed (n=2283), such that 76.0% employed and 77.5% unemployed engaged in no active transport. For employed adults, those engaging in high levels of active transport (≥90 min/week) had higher amount of MVPA than those who did not engage in active transport. This translated to 40.8 (95% CI 15.7 to 65.9) additional minutes MVPA per week in men and 57.9 (95% CI 32.1 to 83.7) additional minutes MVPA per week in women. Among the unemployed adults, higher levels of active transport were associated with more MVPA among men (44.8 min/week MVPA, 95% CI 9.2 to 80.5) only.ConclusionsFindings from the present study support interventions to promote active transport to increase population level physical activity. Additional strategies are likely required to promote physical activity among unemployed women.

Attention facilitates the encoding (e.g., Awh, Anllo-Vento, & Hillyard, J Cognit Neurosci 12(5), 840–847, 2000) and maintenance of locations in spatial working memory (Awh, Vogel, & Oh, Atten, Percept Psychophys 78(4), 1043–1063, 2006). When individuals shift their attention during the maintenance period of a spatial working memory task, their memory of a target location tends to be biased in the direction of the attentional shift (Johnson & Spencer, 2016). Dynamic field theory predicts that in certain conditions, inhibitory mechanisms will result in biases away from distractors presented during the maintenance period of the task. Specifically, dynamic field theory predicts that memory responses will be biased toward distractors that are near the target location and biased away from distractors that are farther from the target location. In two experiments, the current study tested adults in a spatial memory task that required memorization of a single target location. On a subset of trials, a distractor appeared during the memory delay at different distances and directions from the target location. In contrast to the prediction, memory responses were biased away from distractors that were near the target location and not biased by distractors that were far from the target location, providing challenges for, dynamic field theory and other theories of spatial working memory.

This study used ZIP code level data on children's health (National Survey of Children's Health, 2012) and land cover (National Land Cover Database, 2011) from across the United States to investigate connections between proximity to green space (tree canopy), gray space (impervious surfaces), and expression of a critical co-morbid condition, anxiety, in three groups of youth: children diagnosed with autism spectrum disorder (ASD, n = 1501), non-ASD children with special healthcare needs (CSHCN, n = 15,776), and typically developing children (n = 53,650). Both impervious surface coverage and tree canopy coverage increased the risk of severe anxiety in youth with autism, but not CSHCN or typical children. Children with ASD might experience the stress-reducing benefits of nature differently than their typically developing peers. More research using objective diagnostic metrics at finer spatial scales would help to illuminate complex relationships between green space, anxiety, and other co-morbid conditions in youth with ASD.

Background Hyperkalemia is a common and life–threatening complication frequently seen in patients with acute kidney injury, end–stage renal disease and chronic heart failure. Cardiac arrest and ventricular fibrillation are possible consequences. Biosensors are currently being developed to measure serum potassium under ambulatory conditions and trigger an alarm if the potassium concentration exceeds normal limits. Only few studies exist on the circadian rhythm of potassium; and its dependence on age and kidney function is less clear. Methods Our observational monocentric exploratory study included 30 subjects of which 15 had impaired renal function (RF) (GFR\60 ml/min/1.73 m2). Subjects were further categorized into three age groups: 18 39 years (N normal RF = 5, N impaired RF = 4), 40 59 years (N normal RF = 5, N impaired RF = 6), 60 80 years (N normal RF = 5, N impaired RF = 5). Serum potassium levels were measured every 2 h during a 24 h period and repeated once after 2, 4, or 6 days." "Results In the 15 subjects with normal RF, the lowest mean potassium level (3.96 ± 0.14 mmol/l) was observed at 9 p.m. and the greatest (4.23 ± 0.23 mmol/l) at 1 p.m. In patients with impaired RF the lowest mean potassium level (4.20 ± 0.32 mmol/l) was observed at 9 p.m. and the highest (4.57 ± 0.46 mmol/l) at 3 p.m. The range between the mean of minimum and maximum was greater in patients with impaired RF (0.71 ± 0.45 mmol/l) than in subjects with normal RF (0.53 ± 0.14 mmol/l) [p\0.001]. No difference in the circadian rhythm was found between the first and second examination." "Conclusion Our results indicate that patients with normal and impaired RF have comparable circadian patterns of serum potassium concentrations, but higher fluctuations in patients with impaired RF. These results have clinical relevance for developing an automatic biosensor to measure the potassium concentration in blood under ambulatory conditions in patients at high risk for potassium fluctuations.

Background Epidemiological evidence proposes the direct involvement of the liver enzymes in atrial fibrillation. These relationships are controversial and mechanistically unclear. As part of the British Regional Heart Study, we investigated whether change in liver enzymes over time associates with atrial fibrillation in men initially free of this heart condition. Materials and Methods We prospectively investigated change (delta) in liver enzymes and new-onset atrial fibrillation in a representative sample of 1428 men aged 60-79 years. Results Mean follow-up was 12.3 years, after which 108 new atrial fibrillation cases were identified. The liver enzymes did not differ at baseline or follow-up, except for gamma-glutamyl transferase which was higher at follow-up in men who developed atrial fibrillation compared to those who did not (P

Early in development, there is a transition in spatial working memory (SWM). When remembering a location in a homogeneous space (e.g., in a sandbox), young children are biased toward the midline symmetry axis of the space. Over development, a transition occurs that leads to older children being biased away from midline. The dynamic field theory (DFT) explains this transition in biases as being caused by a change in the precision of neural interaction in SWM and improvements in the perception of midline. According to the DFT, young children perceive midline, but there is a quantitative improvement in the perception of midline over development. In the experiment reported here, children and adults needed to determine on which half of a large monitor a target was located. In support of the DFT, even the youngest children performed above chance at most locations, but performance also improved gradually with age.

In early childhood, there is a developmental transition in spatial memory biases. Before the transition, children's memory responses are biased toward the midline of a space, while after the transition responses are biased away from midline. The Dynamic Field Theory (DFT) posits that changes in neural interaction and changes in how children perceive frames of reference underlie the transition. Here, we tested a prediction of the DFT that children younger than the transitional age would show the more advanced developmental pattern when tested with a perceptually salient midline axis. Four age groups (3 years, 6 months; 3 years, 8 months; 4 years; and 5 years) were tested at targets near midline. As predicted, children's responses were biased away from midline.

This study tested a dynamic field theory (DFT) of spatial working memory and an associated spatial precision hypothesis (SPH). Between three and six years of age there is a qualitative shift in how children use reference axes to remember locations: 3-year-olds’ spatial recall responses are biased toward reference axes after short memory delays, whereas 6-year-olds’ responses are biased away from reference axes. According to the DFT and the SPH, quantitative improvements over development in the precision of excitatory and inhibitory working memory processes lead to this qualitative shift. Simulations of the DFT in Experiment 1 predict that improvements in precision should cause the spatial range of targets attracted toward a reference axis to narrow gradually over development with repulsion emerging and gradually increasing until responses to most targets show biases away from the axis. Results from Experiment 2 with 3- to 5-year-olds support these predictions. Simulations of the DFT in Experiment 3 quantitatively fit the empirical results and offer insights into the neural processes underlying this developmental change.

Within cognitive neuroscience, computational models are designed to provide insights into the organization of behavior while adhering to neural principles. These models should provide sufficient specificity to generate novel predictions while maintaining the generality needed to capture behavior across tasks and/or time scales. This paper presents one such model, the dynamic field theory (DFT) of spatial cognition, showing new simulations that provide a demonstration proof that the theory generalizes across developmental changes in performance in four tasks-the Piagetian A-not-B task, a sandbox version of the A-not-B task, a canonical spatial recall task, and a position discrimination task. Model simulations demonstrate that the DFT can accomplish both specificity-generating novel, testable predictions-and generality-spanning multiple tasks across development with a relatively simple developmental hypothesis. Critically, the DFT achieves generality across tasks and time scales with no modification to its basic structure and with a strong commitment to neural principles. The only change necessary to capture development in the model was an increase in the precision of the tuning of receptive fields as well as an increase in the precision of local excitatory interactions among neurons in the model. These small quantitative changes were sufficient to move the model through a set of quantitative and qualitative behavioral changes that span the age range from 8 months to 6 years and into adulthood. We conclude by considering how the DFT is positioned in the literature, the challenges on the horizon for our framework, and how a dynamic field approach can yield new insights into development from a computational cognitive neuroscience perspective.

Inadequate substrate availability and increased nitric oxide synthase inhibitor levels attenuate nitric oxide (NO) synthesis, whereas increased vascular oxidative stress may lead to inactivation of NO. We compared markers of NO synthesis capacity and oxidative stress in a bi-ethnic male population. Inter-relationships of ambulatory blood pressure and urinary albumin-to-creatinine ratio with NO synthesis capacity and oxidative stress markers were investigated. NO synthesis capacity markers (L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA)) and oxidative stress markers (serum peroxides, total glutathione, glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), and catalase) were measured. Black men displayed higher blood pressure and albumin-to-creatinine ratio (all p