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Abstract Background Platinum-based drugs are widely used in cancer therapy, but are known for toxic side effects and resistance. Combinational drug delivery represents an effective chemotherapeutic strategy, but often leads to an increased toxicity. Aim of this study is to test the co-delivery of cisplatin with natural antioxidants on hierarchial porous large surface area hexagonal nanocarriers for synergistic action. Results A series of structured mesoporous materials were impregnated with magnetic spinel ferrite (30% CuFe2O4) and then coated with curcumin (25% wt/wt). Mesosilicalite and MCM-41 with high curcumin release abilities were functionalized with cisplatin (5% wt/wt) for synergistic effect of combinational drugs. The cytotoxic efficiency of our nanocomposites was tested on cell viability of MCF7 (human breast cancer), human cervical cancer (HeLa), colorectal cancer (HCT116), and HFF (human foreskin fibroblasts) cell lines using the MTT cell viability assay. At a concentration of 0.1 mg/ml, CuFe2O4/mesosilicalite/curcumin/cisplatin resulted in 89.53% reduction in viability in MCF7, 94.03% in HeLa, 64% in HCT116 and 87% in HFF; whereas, CuFe2O4/MCM-41/curcumin/cisplatin resulted in 76% reduction in viability in MCF7, 64.46% in HeLa, 64% in HCT116 and 24% in HFF. The EC50 for CuFe2O4/mesosilicalite/curcumin/cisplatin was 81.23 µg/ml in MCF7, 47.55 µg/ml in HeLa, 48.96 µg/ml in HCT116 and 76.83 µg/ml in HFF. The EC50 for CuFe2O4/MCM-41/curcumin/cisplatin was 72.51 µg/ml in MCF7, 58.6 µg/ml in HeLa, 62.58 µg/ml in HCT116 and 154.2 µg/ml in HFF. Furthermore, cells treated with both nanocomposites had a high number of cleaved Caspase 3-positive cells suggesting that the reduction in cell viability was triggered by activating the apoptotic signaling pathway. Conclusion Our results show that CuFe2O4/MCM-41/curcumin/cisplatin is a better candidate for combinational drug therapy due to its lowest EC50 value and the wider difference in EC50 (a fold change) between cancerous and non-cancerous cell line.

Objectives: To normalize the instrument for the appraisal of WhatsApp Addiction Test, to build up the dependability, legitimacy and other psychometric properties of the WhatsApp habit Test and To produce the standards for the instrument for the evaluation of WhatsApp Addiction Test. Methods: On the off chance that the respondents score lies between 24 to 36, they are deciphered to have Moderate/marginal degree of WhatsApp Addiction. If the respondents score lies from 33 to 69, they are deciphered to have Clinically Significant degree of WhatsApp Addiction. Results: This shows that they are feeling the squeeze in utilizing their WhatsApp, these people do not have control in their utilization, other than any place and at whatever point it is. They get so genuinely joined to the WhatsApp that even a little change in their utilization will influence their life. Conclusion: Score 0-23: Insignificant/Appropriate WhatsApp utilization, Score 24-46: Marginal/Borderline degree of WhatsApp Addiction and Score 37-69: Clinically Significant degree of WhatsApp Addiction. [ABSTRACT FROM AUTHOR]

In recent times, higher education institutions (HEIs) are seeking more attention in conducting surveys to improve the quality of teaching and achieve academic accreditation. In this regard, Imam Abdulrahman Bin Faisal University (IAU) also conducting various surveys to meet the requirements of the National Center for Academic Accreditation and evAluation (NCAAA), Saudi Arabia for attaining academic accreditation. Among those surveys, a survey named "Students Survey on Lecturing Skills (SSLS)" is conducted to reveal the students' perception of lecturing skills of instructors. In SSLS, the policymakers should reach the fixed new target benchmark for overall students' satisfaction during every academic year. Therefore, this study aimed to use stochastic modeling to predict the exact parameters which are to be focused by the instructors to improve their quality of teaching and enhance the overall students' satisfaction towards instructors' lecturing skills. The results showed that the instructors should focus on "Interest and motivation" (to enhance the overall students' satisfaction towards the lecturing skills by 99% in the presence of a 5% increase in target benchmark as per NCAAA standards during the upcoming academic year. This study indicates that the policymakers can make use of stochastic modeling in higher education to predict the exact parameters to be focused so that the cost and time spent would be reduced and make the process easier to achieve academic accreditation. [ABSTRACT FROM AUTHOR]

Background: Physiotherapy research supports the advancement of evidence-based practice and the development of a highly skilled workforce. This study aims to visualize the highly cited scientific output of Indian physiotherapists from 1999 to 2018. Methods: A descriptive study design was adopted to visualize the highly cited scientific output of Indian physiotherapists using the Web of Science (WoS) database from 1999 to 2018. A search was carried out using the following keywords "((TS=(physiotherapy) OR TS=("physical rehabilitation") OR TS=("physical therapy")) AND AD=(India))Indexes=SCI-EXPANDED, SSCI, A&HCI, CPCI-S, CPCI-SSH, ESCI, CCR-EXPANDED, IC Timespan=1999-2018". Data collected were analyzed using Incites from WoS and VOSviewer software. Results:   A total of 488 articles were published between 1999 and 2018, with a peak of 103 in 2016 with 2419 citations. A decline in publication count was observed after 2016. The journal International Journal of Physiotherapy published the highest number of articles (n=35). Manipal University (n=36) was found to be the most active institution for physiotherapy research in India, as determined by publishing the most articles. Indian physiotherapists published the highest number of research articles in collaboration with US authors (n=24). Conclusion: There is an increasing trend in the scientific output of Indian physiotherapists over the past two decades; however, a decline is observed after 2016. It is recommended that research collaborations across the globe are increased and scientific output should be improved, leading to a higher number of citations. Future research should explore factors influencing the scientific production of Indian physiotherapists and devise appropriate strategies to attain further improvement., Competing Interests: No competing interests were disclosed., (Copyright: © 2020 Subbarayalu AV et al.)