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BACKGROUND: Prevalence of vulvovaginal dermatosis is not known in Mexico. OBJECTIVE: To identify the frequency and distribution of vulvovaginal dermatosis in the Dermatology Department of the General Hospital Dr. Manuel Gea González located in Mexico City. MATERIAL AND METHOD: A retrospective and descriptive study that included data of patients of any age that underwent biopsy of the vulvar region in the time period of 1979 to 2015, in the Dermatology Department of the General Hospital Dr. Manuel Gea Gonzalez. RESULTS: A total of 354 histologic reports of the vulvar region were included. The five most frequent diagnoses were vulvar melanosis, epidermoid cyst, condyloma acuminatum and cutaneous changes due to HPV, lichen sclerosus and lichen planus. We found a high frequency of pigmented lesions (n = 117), the most frequent pigmented lesion was vulvar melanosis. The frequency of malignant and premalignant neoplasms was low. CONCLUSIONS: We found a frequency of benign and cystic lesions similar to that reported in worldwide literature; the most frequent lesions found in our study were pigmented lesions of the vulva. [ABSTRACT FROM AUTHOR]