37 results on '"R. Grozdanovski"'
Search Results
2. DIALYSIS CARDIOVASCULAR COMPLICATIONS 1
- Author
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D. C. Wheeler, S. Abdalla, G. Chertow, P. Parfrey, C. Herzog, I. Mikolasevic, S. Racki, V. Lukenda, S. Milic, B. Devcic, L. Orlic, M. M. Suttorp, T. Hoekstra, G. Ocak, A. T. N. Van Diepen, I. Ott, M. Mittelman, T. J. Rabelink, R. T. Krediet, F. W. Dekker, S. Simone, M. P. S. Dell'Oglio, M. Ciccone, R. Corciulo, G. Castellano, C. Balestra, G. Grandaliano, L. Gesualdo, G. Pertosa, M. Nishida, M. Ando, K. Karasawa, Y. Iwamoto, K. Tsuchiya, K. Nitta, M. Krzanowski, K. Janda, M. Gajda, P. Dumnicka, D. Fedak, G. Lis, P. Ja kowski, J. A. Litwin, W. Su owicz, G. R. Freitas, V. B. Silva, H. Abensur, C. Luders, B. J. Pereira, M. C. Castro, R. B. Oliverira, R. M. Moyses, R. M. Elias, B. C. Silva, H. Tekce, S. Ozturk, G. Aktas, B. Kin Tekce, A. Erdem, M. Ozyasar, T. Taslamacioglu Duman, M. Yazici, A. Kirkpantur, M. M. Balci, A. Turkvatan, B. Afsar, M. Alkis, F. Mandiroglu, L. Voroneanu, D. Siriopol, I. Nistor, M. Apetrii, S. Hogas, M. Onofriescu, A. Covic, W. S. An, S. E. Kim, Y. K. Son, Y. J. Oh, S. Gelev, S. Toshev, L. Trajceska, G. Selim, P. Dzekova, A. Shikole, J. Park, J. S. Lee, E.-S. Shin, S. H. Ann, S.-J. Kim, H. C. Chung, W. Sulowicz, U. Elewa, W. Bichari, K. Abo-Seif, S. Seferi, M. Rroji, E. Likaj, N. Spahia, M. Barbullushi, N. Thereska, C. M. Kopecky, B. Genser, W. Maerz, C. Wanner, M. D. Saemann, T. Weichhart, S. Sezer, B. Gurlek Demirci, E. Tutal, Z. Bal, M. Erkmen Uyar, F. N. Ozdemir Acar, B. Macunluoglu, A. Atakan, E. Ari Bakir, P. Georgianos, P. A. Sarafidis, D. N. Stamatiadis, V. Liakopoulos, P. E. Zebekakis, A. Papagianni, A. N. Lasaridis, N. Eftimovska - Otovic, E. Babalj-Banskolieva, S. Kostadinska-Bogdanoska, R. Grozdanovski, M. Aono, Y. Sato, M. El Amrani, M. Asserraji, M. Benyahia, Y.-K. Lee, S. R. Choi, A. Cho, J.-K. Kim, M.-J. Choi, S. J. Kim, J.-W. Yoon, J.-R. Koo, H. J. Kim, J.-W. Noh, H. Inagaki, N. Yokota, S. Chiyotanda, K. Fukami, S. Fujimoto, Z. Kendi Celebi, S. Kutlay, S. Sengul, G. Nergizoglu, S. Erturk, K. Ates, K. A. Vishnevskii, A. S. Rumyantsev, A. Y. Zemchenkov, A. V. Smirnov, B. Reinhardt, R. Knaup, V. Esteve Simo, J. Carneiro Oliveira, F. Moreno Guzman, M. Fulquet Nicolas, M. Pou Potau, A. Saurina Sole, V. Duarte Gallego, M. Ramirez De Arellano Serna, K. Turkmen, L. Demirtas, E. M. Akbas, E. M. Bakirci, M. Buyuklu, A. Timuroglu, P. I. Georgianos, A. Karpetas, T. Taira, K. Nohtomi, T. Takemura, T. Chiba, T. Hirano, C.-T. Chang, C.-C. Huang, C.-J. Chen, A. Mohamed, H. Kanai, Y. Tamura, Y. Kaizu, A. Kali, O. Yayar, B. Erdogan, B. Eser, Z. Ercan, M. Buyukbakkal, O. Merhametsiz, A. Haspulat, T. Yildirim, B. Bozkurt, M. D. Ayli, D. Gokustun, A. Markaki, M. Grammatikopoulou, G. Fragkiadakis, K. Stylianou, M. Venyhaki, V. Chatzi, O. Stojceva-Taneva, L. Tozija, P. Dzekova-Vidimliski, Z. Petronievic, A. Sikole, V. Moyseyenko, T. Nykula, R. T. Fernandes, D. V. Barreto, G. G. C. Rodrigues, A. Misael, C. T. Branco-Martins, and F. C. Barreto
- Subjects
Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,medicine ,Intensive care medicine ,business ,Dialysis (biochemistry) - Published
- 2014
3. Lanthanum Carbonate in the Management of Renal Osteodystrophy in Dialysis Patients
- Author
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V. Amitov, M.E. De Broe, Patrick C. D'Haese, R. Grozdanovski, Saso Gelev, Goce Spasovski, and A. Sikole
- Subjects
medicine.medical_specialty ,business.industry ,medicine.drug_class ,Bicarbonate ,Inorganic chemistry ,chemistry.chemical_element ,Hematology ,Calcium ,Phosphate ,medicine.disease ,Phosphate binder ,chemistry.chemical_compound ,Lanthanum carbonate ,Endocrinology ,Calcium carbonate ,chemistry ,Nephrology ,Internal medicine ,medicine ,Lanthanum ,Hypocalcaemia ,business ,medicine.drug - Abstract
In an open label, randomized, parallel group study, we treated ten patients with lanthanum carbonate and ten patients with calcium carbonate to control their serum phosphate levels. All patients were initiated onto dialysis within 12 weeks of recruitment to the study. They were on maintenance bicarbonate haemodialysis for 12 hours per week, with low flux polysulphone or hemophane membrane, and required phosphate control by the use of oral phosphate binders. Both phosphate binders were given with meal, divided into three equal doses. The maximum allowed daily dose of lanthanum carbonate and calcium carbonate was 3750 mg and 9000 mg, respectively. The duration of the study was one year. Serum phosphate levels were controlled well in both groups with no difference between them. In the lanthanum group mean phosphate level varied between 1.3 and 1.9 mmol/l, whilst in the calcium carbonate group it varied between 1.3 and 1.65 mmol/l. The maximum mean daily dose reached 1450 +/− 610 mg in the lanthanum carbonate group and 2400 +/− 1400 mg in the calcium carbonate group. In both groups, serum calcium levels did not vary significantly during the study. Mean serum calcium was 2.12 +/− 0.02 mmol/l in the lanthanum carbonate group and 2.33 +/−0.09 mmol/l in the calcium carbonate group. Bone alkaline phosphatase did not significantly vary between the two treatment groups, remaining at the upper limit of the referent values. The mean value of PTH level in the lanthanum carbonate group was 33 +/−6.2 pmol/l, and differed significantly from the mean PTH level at the calcium carbonate group –23 +/− 5.9 pmol/l (PTH ref. values 1.05– 6.84 pmol/l). In the both groups the mean levels of 25 vitamin D and 1,25 vitamin D were similar and throughout the study remained at the lower limit of the referent values. Lanthanum carbonate proved a safe phosphate binder, as we noted no serious adverse events, except for sporadic, clinically non-relevant hypocalcaemia. We could conclude that lanthanum carbonate was a safe and effective phosphate binder and it could better prevent hypercalcaemia.
- Published
- 2003
4. Survival of patients on maintenance haemodialysis over a twenty-year period
- Author
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A, Sikole, V, Nikolov, P, Dzekova, N, Stojcev, V, Amitov, G, Selim, A, Asani, S, Gelev, R, Grozdanovski, G, Masin, H, Klinkmann, and M, Polenakovic
- Subjects
Adult ,Male ,Survival Rate ,Renal Dialysis ,Humans ,Kidney Failure, Chronic ,Female ,Middle Aged ,Survival Analysis ,Aged - Abstract
Patient survival is a key index of the overall adequacy of treatment in most chronic diseases. Analyses of survival of patients undergoing haemodialysis is very important, as it may offer clues and ideas for prolonging survival of patients with end-stage renal disease (ESRD). The aims of this study were to describe the characteristics of the patients on maintenance haemodialysis therapy over a period of 20 years, to determine the survival rate of these patients according to ages at the onset of haemodialysis, the primary renal diseases, and the cause of death, and to determine the survival rate at five, ten, fifteen and twenty years of haemodialysis treatment at our centre. The charts of 518 unselected patients, 282 male and 236 female, treated with maintenance haemodialysis therapy in a period of 20 years (1985-2005) were reviewed. At the time of evaluation, 164 patients were currently being treated, and 354 patients overall had been diseased. Statistical analysis was performed to evaluate the relationship between survival and patient characteristics such as age, gender, primary renal disease, and age at dialysis onset. Actual survival rates were determined by the Kaplan-Meier method. The survival rate of our patients treated with maintenance haemodialysis was 60% at 5 years, 37% at 10 years, 25% at 15 years and 9% at 20 years. Female patient survival was superior to male. Patients aged under 40 at the start of dialysis had a better survival probability compared to older patients. Patients with diabetes mellitus and nephroangiosclerosis, had a lower survival rate compared to patients with glomerulonephritis and with adult dominant polycystic kidney disease. Cardiac death was the most common cause of death in patients involved in the study. About 52% of the patients died from cardiovascular disease. Death is the most severe consequence of inadequate dialysis and can be used as an index of the adequacy of the dialysis therapy. Treatment factors that may improve outcomes include an early start of dialysis therapy, a high dose of dialysis (Kt/V over 1.2), correction of anemia, adequate protein and caloric intake, control of calcium and phosphate metabolism, and the use of biocompatible dialyzers.
- Published
- 2008
5. Malnutrition inflammation complex syndrome in maintenance haemodialysis patients
- Author
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P, Dzekova, I G, Nikolov, A, Sikole, R, Grozdanovski, and M H, Polenaković
- Subjects
Inflammation ,Male ,C-Reactive Protein ,Renal Dialysis ,Malnutrition ,Humans ,Female ,Syndrome ,Middle Aged ,Serum Albumin - Abstract
Malnutrition inflammation complex syndrome (MICS) occurs in maintenance haemodialysis (MHD) patients and is a strong predictor of morbidity and mortality in these patients. The aim of our study was to evaluate the influence of inflammation on the biochemical and anthropometrical parameters of the nutritional status in MHD patients. Our study was made on 154 patients (93 men and 61 women, mean age=54.7 yrs. and mean time on dialysis 84 months) over a period of 6 months. The indicator of inflammation, C-reactive protein (CRP), was measured monthly at the central laboratory by nephelometry. The assessment tools used to evaluate the influence of inflammation on the nutritional status in MHD patients were: serum albumin and cholesterol level, midarm circumference (MAC), midarm muscle circumference (MAMC), triceps skin fold thickness (TSF) and body mass index (BMI). Student's t-test was used for group mean comparison between men and women. Person's correlation r was used to determine the significance and the strength of associations. The CRP level was significantly greater in men than in women (12.9 vs. 7.97, p0.04). The CRP level showed a strong correlation only with the serum concentration of cholesterol (r=0.49, p0.000), and did not correlate with the serum albumin of the MHD patients. There was no correlation between the CRP level and the anthropometrical parameters of the MHD patients in our study. Two separate processes, inflammation and reduced protein intake, each separately contributed to causing a decrease in serum albumin concentration and anthropometrical measurements. The levels of acute phase proteins vary widely as opposed to the serum albumin level; for that reason, changes in the albumin catabolic rate or synthesis require a considerable time to become visible. The average value of the protein catabolic rate of the patients in our study was 1.01 g/kg/d, a value that showed adequate protein intake. These findings would suggest that clinical attention to the maintenance of adequate nutrition could blunt the effects of inflammation on both somatic and visceral protein stores.
- Published
- 2005
6. Short-term effect of folic acid supplementation in renal transplant recipients and chronic kidney disease patients with comparable renal function impairment
- Author
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N, Ivanovski, O, Stojceva-Taneva, R, Grozdanovski, M, Boskovska, T B, Drueke, and Z A, Massy
- Subjects
Adult ,Male ,Folic Acid ,Chronic Disease ,Humans ,Female ,Kidney Diseases ,Middle Aged ,Kidney ,Homocysteine ,Kidney Transplantation - Abstract
Recent evidence suggested that the efficacy of folic acid supplementation in reducing plasma total homocysteine (Hcy) concentration might be similar in renal transplant recipients (RTR) and chronic kidney disease (CKD) patients with a comparable degree of reduction of renal function. However, a direct comparison of the response to high dose folic acid supplementation between renal transplant recipients and CKD patients has never been made. Therefore, the goal of this study was to evaluate the response to folic acid (5 mg/day) supplementation in 15 stable renal transplant recipients with evidence of chronic allograft nephropathy, and in 15 CKD (stage 3) patients matched for age, sex and renal function living in the area of Skopje, Macedonia. After 12 weeks of folic acid supplementation, plasma total Hcy concentrations were significantly reduced in the two groups. Percent reduction of plasma total Hcy levels was nearly identical in the two groups (25.7% vs 24.5%, p = NS). These results confirm previous findings regarding the efficacy of folic acid therapy given separately to either renal transplant recipients or CKD patients, and extend them to a direct confirmation of identical efficacy.
- Published
- 2004
7. Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril
- Author
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L, Grcevska, M, Polenaković, S, Dzikova, and R, Grozdanovski
- Subjects
Adult ,Male ,Microscopy, Electron ,Kidney Tubules ,Enalapril ,Nephrosis, Lipoid ,Humans ,Prednisone ,Acute Kidney Injury ,Kidney ,Cyclophosphamide ,Methylprednisolone - Abstract
A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril. Renal biopsy demonstrated minimal glomerular changes with fusion of podocytes, tubular necrosis with regeneration of tubular epithelial cells, interstitial edema with focal interstitial fibrosis, and interstitial infiltration with neutrophils, eosinophils, plasma cells and mononuclear cells. Three hemodialyses were performed in the patient during the oliguric phase of the disease. Renal function was restored after withdrawal of enalapril and initiation of steroid therapy. Steroids also contributed to the improvement of the nephrotic syndrome and proteinuria decreased from maximal ranges of 27 g/l to 2.2 g/l after six months of the follow-up. Similar cases were previously described associated with captopril treatment, but not with enalapril.
- Published
- 1997
8. Long-term diuretic therapy in patients with chronic renal failure
- Author
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K, Cakalaroski, N, Ivanovski, R, Grozdanovski, V, Ristovska, and M, Polenakovic
- Subjects
Polythiazide ,Time Factors ,Furosemide ,Sodium Chloride Symporter Inhibitors ,Humans ,Kidney Failure, Chronic ,Middle Aged ,Diuretics - Abstract
Ten patients with chronic renal failure from different genesis (serum creatinine levels 150-200 mumol/l), were evaluated from the aspect of the effect of the diuretic therapy. The effects of furosemide (FUR) and polythiazide (POL) were assessed after 3-month application. The mean values of the estimated parameters before treatment, after 3-month administration of FUR as a monotherapy and after the next 3 months simultaneously used (FUR + POL), presented a stable increase of the diuresis, without statistically significant changes of the global renal function, and triglyceride disorders. On the contrary, the improvement of calciuria through combined using of furosemide and polythiazide is statistically and clinically significant.
- Published
- 1997
9. Extracorporeal dialysis: techniques and adequacy
- Author
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C. Donadio, A. Kanaki, A. Martin-Gomez, S. Garcia, M. Palacios-Gomez, D. Calia, E. Colombini, F. DI Francesco, S. Ghimenti, M. Onor, D. Tognotti, R. Fuoco, E. Marka-Castro, M. I. Torres Zamora, J. Giron-Mino, M. A. Jaime-Solis, L. M. Arteaga, H. Romero, A. Akonur, K. Leypoldt, M. Asola, B. Culleton, S. Eloot, G. Glorieux, N. Nathalie, R. Vanholder, A. Perez de Jose, U. Verdalles Guzman, S. Abad Esttebanez, A. Vega Martinez, D. Barraca, C. Yuste, L. Bucalo, A. Rincon, J. M. Lopez-Gomez, P. Bataille, P. Celine, A. Raymond, G. Francois, L. Herve, D. Michel, R. Jean Louis, F. Zhu, P. Kotanko, S. Thijssen, N. W. Levin, N. Papamichail, M. Bougiakli, C. Gouva, S. Antoniou, S. Gianitsi, A. Vlachopanou, S. Chachalos, K. Naka, D. Kaarsavvidou, K. Katopodis, L. Michalis, K. Sasaki, K. Yasuda, M. Yamato, A. Surace, P. Rovatti, D. Steckiph, R. Bandini, S. Severi, A. Dellacasa Bellingegni, A. Santoro, M. Arias, A. Sentis, N. Perez, N. Fontsere, M. Vera, N. Rodriguez, C. Arcal, N. Ortega, F. Uriza, A. Cases, F. Maduell, S. R. Abbas, P. Georgianos, P. Sarafidis, P. Nikolaidis, A. Lasaridis, A. Ahmed, H. Kaoutar, B. Mohammed, O. Zouhir, P. Balter, N. Ginsberg, P. Taylor, T. Sullivan, L. A. Usvyat, P. Zabetakis, U. Moissl, M. Ferrario, F. Garzotto, P. Wabel, D. Cruz, C. Tetta, M. G. Signorini, S. Cerutti, A. Brendolan, C. Ronco, J. Heaf, M. Axelsen, R. S. Pedersen, H. Amine, Z. Oualim, A. L. Ammirati, N. K. Guimaraes de Souza, T. Nemoto Matsui, M. Luiz Vieira, W. A. Alves de Oliveira, C. H. Fischer, F. Dias Carneiro, I. J. Iizuka, M. Aparecida de Souza, A. C. Mallet, M. C. Cruz Andreoli, B. F. Cardoso Dos Santos, L. Rosales, Y. Dou, M. Carter, A. Testa, L. Sottini, B. Giacon, E. Prati, C. Loschiavo, M. Brognoli, C. Marseglia, A. Tommasi, L. Sereni, G. Palladino, S. Bove, G. Bosticardo, E. Schillaci, P. Detoma, R. Bergia, J. W. Park, S. J. Moon, H. Y. Choi, S. K. Ha, H.-C. Park, Y. Liao, L. Zhang, P. Fu, H. Igarashi, N. Suzuki, S. Esashi, I. Masakane, V. Panichi, G. De Ferrari, S. Saffiotti, A. Sidoti, M. Biagioli, S. Bianchi, P. Imperiali, C. Gabrielli, P. Conti, P. Patrone, G. Rombola, V. Falqui, C. Mura, A. Icardi, A. Rosati, F. Santori, A. Mannarino, A. Bertucci, J. Jeong, O. K. Kim, N. H. Kim, M. Bots, C. Den Hoedt, M. P. Grooteman, N. C. Van der Weerd, A. H. A. Mazairac, R. Levesque, P. M. Ter Wee, M. J. Nube, P. Blankestijn, M. A. Van den Dorpel, Y. Park, J. Jeon, N. Tessitore, V. Bedogna, D. Girelli, L. Corazza, P. Jacky, Q. Guillaume, B. Julien, W. Marcinkowski, M. Drozdz, A. Milkowski, T. Rydzynska, T. Prystacki, R. August, E. Benedyk-Lorens, K. Bladek, J. Cina, G. Janiszewska, A. Kaczmarek, T. Lewinska, M. Mendel, M. Paszkot, E. Trafidlo, M. Trzciniecka-Kloczkowska, A. Vasilevsky, G. Konoplev, O. Lopatenko, A. Komashnya, K. Visnevsky, R. Gerasimchuk, I. Neivelt, A. Frorip, M. Vostry, J. Racek, D. Rajdl, J. Eiselt, L. Malanova, U. Pechter, A. Selart, M. Ots-Rosenberg, D. H. Krieter, S. Seidel, K. Merget, H.-D. Lemke, C. Wanner, B. Canaud, A. Rodriguez, A. Morgenroth, K. Von Appen, G.-P. Dragoun, R. Fluck, D. Fouque, R. Lockridge, Y. Motomiya, Y. Uji, T. Hiramatsu, Y. Ando, M. Furuta, T. Kuragano, A. Kida, M. Yahiro, Y. Otaki, Y. Hasuike, H. Nonoguchi, T. Nakanishi, M. Sain, V. Kovacic, D. Ljutic, J. Radic, I. Jelicic, S. F. Yalin, S. Trabulus, A. S. Yalin, M. R. Altiparmak, K. Serdengecti, A. Ohtsuka, K. Fukami, K. Ishikawa, R. Ando, Y. Kaida, T. Adachi, K. Sugi, S. Okuda, O. B. Nesterova, E. D. Suglobova, R. V. Golubev, A. N. Vasiliev, V. A. Lazeba, A. V. Smirnov, K. Arita, E. Kihara, K. Maeda, H. Oda, S. Doi, T. Masaki, S. Hidaka, K. Ishioka, M. Oka, H. Moriya, T. Ohtake, S. Nomura, S. Kobayashi, S. Wagner, A. Gmerek, J. Wagner, V. Wizemann, N. Eftimovska - Otovic, K. Spaseska-Gjurovska, S. Bogdanovska, E. Babalj - Banskolieva, M. Milovanceva, R. Grozdanovski, A. Pisani, E. Riccio, A. Mancini, P. Ambuhl, S. Astrid, P. Ivana, H. Martin, K. Thomas, R. Hans-Rudolf, A. Daniel, K. Denes, M. Marco, R. P. Wuthrich, S. Andreas, S. Andrulli, P. Altieri, G. Sau, P. Bolasco, L. A. Pedrini, C. Basile, S. David, M. Feriani, P. E. Nebiolo, R. Ferrara, D. Casu, F. Logias, R. Tarchini, F. Cadinu, M. Passaghe, G. Fundoni, G. Villa, B. R. DI Iorio, C. Zoccali, F. Locatelli, M. Hamamoto, D.-Y. Lee, B. Kim, K. H. Moon, Z. LI, P. Ahrenholz, R. E. Winkler, G. Waitz, H. Wolf, G. Grundstrom, M. Alquist, M. Holmquist, A. Christensson, P. Bjork, M. Abdgawad, L. Ekholm, M. Segelmark, C. Corsi, J. De Bie, E. Mambelli, D. Mortara, D. Arroyo, N. Panizo, B. Quiroga, J. Reque, R. Melero, M. Rodriguez-Ferrero, P. Rodriguez-Benitez, F. Anaya, J. Luno, A. Ragon, A. James, P. Brunet, S. Ribeiro, M. S. Faria, S. Rocha, S. Rodrigues, C. Catarino, F. Reis, H. Nascimento, J. Fernandes, V. Miranda, A. Quintanilha, L. Belo, E. Costa, A. Santos-Silva, J. Arund, R. Tanner, I. Fridolin, M. Luman, C. Clajus, J. T. Kielstein, H. Haller, P. Libutti, P. Lisi, L. Vernaglione, F. Casucci, N. Losurdo, A. Teutonico, C. Lomonte, C. Krisp, D. A. Wolters, M. Matsuyama, T. Tomo, K. Ishida, K. Matsuyama, T. Nakata, J. Kadota, M. Caiazzo, E. Monari, A. Cuoghi, E. Bellei, S. Bergamini, A. Tomasi, T. Baranger, P. Seniuta, F. Berge, V. Drouillat, C. Frangie, E. Rosier, W. Labonia, A. Lescano, D. Rubio, N. Von der Lippe, J. A. Jorgensen, T. B. Osthus, B. Waldum, I. Os, M. Bossola, E. DI Stasio, M. Antocicco, L. Tazza, I. Griveas, A. Karameris, P. Pasadakis, V. Savica, D. Santoro, S. Saitta, V. Tigano, G. Bellinghieri, S. Gangemi, R. Daniela, I. A. Checherita, A. Ciocalteu, I. A. Vacaroiu, A. Niculae, E. Stefaniak, I. Pietrzak, D. Krupa, L. Garred, E. Mancini, L. Corrazza, M. Atti, B. Afsar, D. Stamopoulos, N. Mpakirtzi, B. Gogola, M. Zeibekis, D. Stivarou, M. Panagiotou, E. Grapsa, O. Vega Vega, D. Barraca Nunez, M. Fernandez-Lucas, A. Gomis, J. L. Teruel, S. Elias, C. Quereda, L. Hignell, S. Humphrey, N. Pacy, and N. Afentakis
- Subjects
Transplantation ,medicine.medical_specialty ,Extracorporeal Dialysis ,Nephrology ,business.industry ,Uremic toxins ,Medicine ,Identification (biology) ,business ,Intensive care medicine ,Microbiology - Published
- 2011
10. Tubular markers in diabetes in relation to microangiopathy
- Author
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Olivera Stojceva-Taneva, N. Ivanovski, R. Grozdanovski, Momir Polenakovic, and T. Gruev
- Subjects
Pathology ,medicine.medical_specialty ,Nephrology ,business.industry ,Diabetes mellitus ,Microangiopathy ,Medicine ,business ,medicine.disease - Published
- 1996
11. SURVIVAL OF PATIENTS ON MAINTENANCE HAEMODIALYSIS OVER A TWENTY-YEAR PERIOD.
- Author
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A., Sikole, V., Nikolov, P., Dzekova, N., Stojcev, V., Amitov, G., Selim, A., Asani, S., Gelev, R., Grozdanovski, G., Masin, H., Klinkmann, and M., Polenakovic
- Subjects
HEMODIALYSIS patients ,CHRONIC disease treatment ,CHRONIC kidney failure ,KIDNEY diseases ,PEOPLE with diabetes ,GLOMERULONEPHRITIS ,POLYCYSTIC kidney disease ,CARDIAC arrest ,PATIENTS - Abstract
Patient survival is a key index of the overall adequacy of treatment in most chronic diseases. Analyses of survival of patients undergoing haemodialysis is very important, as it may offer clues and ideas for prolonging survival of patients with end-stage renal disease (ESRD). The aims of this study were to describe the characteristics of the patients on maintenance haemodialysis therapy over a period of 20 years, to determine the survival rate of these patients according to ages at the onset of haemodialysis, the primary renal diseases, and the cause of death, and to determine the survival rate at five, ten, fifteen and twenty years of haemodialysis treatment at our centre. The charts of 518 unselected patients, 282 male and 236 female, treated with maintenance haemodialysis therapy in a period of 20 years (1985-2005) were reviewed. At the time of evaluation, 164 patients were currently being treated, and 354 patients overall had been diseased. Statistical analysis was performed to evaluate the relationship between survival and patient characteristics such as age, gender, primary renal disease, and age at dialysis onset. Actual survival rates were determined by the Kaplan-Meier method. The survival rate of our patients treated with maintenance haemodialysis was 60%, at 5 years, 37% at 10 years, 25% at 15 years and 9% at 20 years. Female patient survival was superior to male. Patients aged under 40 at the start of dialysis had a better survival probability compared to older patients. Patients with diabetes mellitus and nephroangiosclerosis, had a lower survival rate compared to patients with glomerulonephritis and with adult dominant polycystic kidney disease. Cardiac death was the most common cause of death in patients involved in the study. About 52% of the patients died from cardiovascular disease. Death is the most severe consequence of inadequate dialysis and can be used as an index of the adequacy of the dialysis therapy. Treatment factors that may improve outcomes include an early start of dialysis therapy, a high dose of dialysis (Kt/V over 1.2), correction of anemia, adequate protein and caloric intake, control of calcium and phosphate metabolism, and the use of biocompatible dialyzers. [ABSTRACT FROM AUTHOR]
- Published
- 2007
12. [Size of the kidney as an element of clinical evaluation]
- Author
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R, Grozdanovski
- Subjects
Humans ,Kidney Diseases ,Organ Size ,Kidney ,Kidney Function Tests - Published
- 1976
13. [Lupus nephritis]
- Author
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M, Polenaković, R, Grozdanovski, S, Dzikova, and L, Grcevska
- Subjects
Adult ,Nephritis ,Humans ,Lupus Erythematosus, Systemic ,Female ,Acute Kidney Injury - Published
- 1977
14. [Dialysis--ascites syndrome]
- Author
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G, Masin, J, Jovanovski, K, Cakalarski, and R, Grozdanovski
- Subjects
Adult ,Male ,Renal Dialysis ,Ascites ,Humans ,Kidney Failure, Chronic ,Syndrome - Published
- 1976
15. [Renal anemia in relation to the basic pathological status and renal function]
- Author
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R, Grozdanovski
- Subjects
Humans ,Kidney Failure, Chronic ,Anemia ,Kidney Function Tests - Published
- 1976
16. [Cardiotonic therapy in nephrology]
- Author
-
R, Grozdanovski and K, Cakalaroski
- Subjects
Heart Diseases ,Humans ,Kidney Diseases - Published
- 1977
17. [Analysis of the composition of patients hospitalized with kidney diseases in a 1-year period]
- Author
-
D, Hrisoho, M, Polenakovik, and R, Grozdanovski
- Subjects
Adult ,Hospitalization ,Adolescent ,Acute Disease ,Chronic Disease ,Humans ,Kidney Diseases ,Middle Aged - Published
- 1972
18. Clinical Effects of Standard and Individualized Dialysate Sodium in Patients on Maintenance Hemodialysis.
- Author
-
Eftimovska-Otovic N, Stojceva-Taneva O, Grozdanovski R, and Stojcev S
- Abstract
Background: The degree to which the dialysate prescription and, in particular, the dialysate sodium concentration influences blood pressure and interdialytic weight gain (IDWG) via changes in sodium flux, plasma volume or the other parameters is not well understood. The aim of the study was to investigate whether dialysis patients will have some beneficial effects of dialysate sodium set up according to serum sodium or sodium modeling., Material and Methods: Ninety-two nondiabetic subjects (52 men and 40 women) performed 12 consecutive hemodialysis (HD) sessions (4 weeks) with dialysate sodium concentration set up on 138 mmol/L (standard sodium - first phase), followed by 24 sessions (second phase) wherein dialysate sodium was set up according to individualized sodium. Variables of interest were: systolic, diastolic and mean blood pressure, pulse, IDWG, thirst score - (Xerostomia Inventory (XI) and Dialysis Thirst Inventory (DTI)) and side effects (occurrence of hypotension and muscle cramps). After the first phase, the subjects were divided into 3 groups: normotensive (N=76), hypertensive (N= 11) and hypotensive (N=5) based on the average pre-HD systolic BP during the whole period of the first phase., Results: Sodium individualization resulted in significantly lower blood pressure (133.61 ± 11.88 versus 153.60 ± 14.26 mmHg; p=0.000) and IDWG (2.21 ± 0.93 versus 1.87 ± 0.92 kg; p=0.018) in hypertensive patients, whereas normotensive patients showed only significant decrease in IDWG (2.21 ± 0.72 versus 2.06 ± 0.65, p=0,004). Sodium profiling in hypotensive patients significantly increased IDWG (2.45 vs. 2.74, p= 0,006), and had no impact on blood pressure. Thirst score was significantly lower in normotensive patients with individualized-sodium HD and showed no change in the other two groups. During the second phase, hypotension occurred in only 1 case and muscle cramps in 10 normotensive patients., Conclusion: Individualized sodium resulted in clinical benefits in normotensive and hypertensive patients.
- Published
- 2016
- Full Text
- View/download PDF
19. Clinical Characteristics of Patients with Intradialytic Hypertension.
- Author
-
Eftimovska-Otovic N, Grozdanovski R, Taneva B, and Stojceva-Taneva O
- Subjects
- Adult, Age Factors, Aged, Biomarkers blood, Body Mass Index, Case-Control Studies, Female, Humans, Hypertension diagnosis, Hypertension mortality, Hypertension physiopathology, Hyponatremia blood, Hyponatremia epidemiology, Male, Middle Aged, Prevalence, Renal Dialysis methods, Renal Dialysis mortality, Republic of North Macedonia epidemiology, Risk Factors, Sodium blood, Time Factors, Blood Pressure, Hypertension epidemiology, Renal Dialysis adverse effects
- Abstract
Introduction: Intradialytic hypertension with a prevalence of 15% among hemodialysis patients is with unknown pathophysiology, demographic, laboratoiy and clinical characteristic of patients, and it's influence on longtenn clinical effects (cardiovascular morbidity and mortality, rate of hospitalization). The aim of the study is to present the clinical, laboratoiy and demographic characteristics of patients with intradialytic hypertension in our dialysis center., Materials and Methods: Out of 110 hemodialysis patients, 17 patients (15,45%) had intradialytic hypertension - started at a systolic pressure greater than 140 nun Hg or had an increase in systolic pressure more than 10 mm Hg during the session, and 17 patients were nonnotensive or had a drop in blood pressure dining the dialysis. HD were performed 3 times per week with a duration of 4-5 hours, on machines with controlled ultrafiltration and high flux syntetic membrane (polyetersulfon) sterilized with gamma rays. A dialysate with standard electrolytes content was used (Na(+) 138 mmol/L, K(+) 2,0 mmol/L, Ca(++) 1,5 mmol/L, Mg (+)1,0 mmol/L, CH(3)COO(-) 3,0 mmol/L, Cl -110 mmol/1, HCO(3)(-) 35 mmol/L). We analysed the following demographic and clinical characteristics: gender, age, BMI, dialysis vintage, vascular acces, cardiovascular comorbidity (cardiomyopathy, ischemic cardiac disease, peripheral artery disease, heart valve disease), number and type of antihypertensive drugs, weekly dose of erythropoesis - stimulating agent, standard monthly, three and six months laboratoiy analyzes, and sp Kt/V and PCR. Statistical analysis was performed using the statistical software SPSS 17.0., Results: hi both groups men were predominant (IDH group 88.23%, control group 64.07%). The IDH group was older (59.00 ± 7.64 versus 49.00 ± 13.91, p = 0.314) and with lower BMI (p = 0.246) compared to the control group. The DDH patients had significantly lower serum sodium and higher sodium gradient (135.75 ± 2.03 versus 137.33 ± 1.97, p = 0.042; 2.25 ± 1.98 versus 0.66 ± 1.44, p = 0.0267, respestively). All other laboratoiy findings showed no statistically significant differences between the two groups. The IDH group had significantly higher interdialysis weight gain and less effective ultrafiltration individually at each dialysis session compared to the control group (2.23 ± 0.866 versus 2.37 ± 0.69, p = 0.011; 3.87 ± 1,26 versus 3.56 ± 1.18, p = 0.025, respectively). The systolic and mean arterial pressure after the HD were statistically higher in the IDH group., Conclusion: Older age, lower BMI, borderline hyponatremia, higher sodium gradient and smaller ultrafiltration rate are the clinical characteristics of patients with intradialytic hypertension.
- Published
- 2015
- Full Text
- View/download PDF
20. Timing of nephrology referral and initiation of dialysis as predictors for survival in hemodialysis patients: 5-year follow-up analysis.
- Author
-
Selim G, Stojceva-Taneva O, Spasovski G, Tozija L, Grozdanovski R, Georgievska-Ismail L, Zafirova-Ivanovska B, Dzekova P, Trajceska L, Gelev S, Mladenovska D, and Sikole A
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Cardiovascular Diseases mortality, Cause of Death, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Nephrology, Proportional Hazards Models, Retrospective Studies, Survival Rate, Time Factors, Young Adult, Kidney Failure, Chronic mortality, Kidney Failure, Chronic therapy, Referral and Consultation, Renal Dialysis
- Abstract
Background: A consensus about the optimal timing of dialysis initiation is still controversial. Thus, the goal of this analysis was to compare outcomes in patients with early and late referral with early and late initiation of hemodialysis (HD)., Methods: We studied 190 patients (mean age 52.03±14.22) who were initiated on HD between 1994 and 2004. Patients who received regular nephrology care during 12 months before HD initiation were categorized as early referrals (ER) and those without nephrology care were late referrals (LR). The early start (E-start) was defined by the estimated GFR (eGFR) at start of HD≥7.5 mL/min/1.73 m2, and the late start (L-start) by eGFR of <7.5 mL/min/1.73 m2. The four groups of patients (ER with E-start and L-start; LR with E-start and L-start) were prospectively followed in the next 60 months after HD initiation., Results: During the follow-up, 43.3% of E-start and 43.2% of L-start patients died, without significant difference in survival between the groups [HR for L-start vs. E-start=1.06 (95% CI 0.69-1.62); p=0.797]. When survival between ER and LR groups was compared (28.1% patients in the ER and 53.2% in the LR died), there was significant difference in survival [HR for LR vs. ER=2.16 (95% CI 1.28-3.65); p=0.004]. Compared with patients with ER and L-start, higher mortality was observed among those with LR and L-start [HR 3.51 (95% CI 1.48-8.35); p=0.004] and LR with E-start [HR 2.79 (95% CI 1.16-6.7); p=0.022]. There was no significant difference between patients in ER with L-start and ER with E-start., Conclusions: Our study showed that ER above 12 months before HD initiation and L-start of dialysis was associated with a reduced mortality risk in HD patients.
- Published
- 2015
- Full Text
- View/download PDF
21. Protocol for performing nephrological activity in the Republic of Macedonia.
- Author
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Polenakovic M, Bogdanovska S, Cakalaroski K, Dzikova S, Masin G, Masin-Spasovska J, Oncevski A, Gerasimovska V, Spasovski G, Grozdanovski R, Stojceva-Taneva O, Grcevska L, Sikole A, Dejanov P, Tozija L, Zafirovska K, Ivanovski N, Lozance L, and Pusevski V
- Subjects
- Humans, Republic of North Macedonia, Kidney Diseases therapy, Nephrology methods
- Abstract
The fast development of nephrology in the world, especially in the second half of the 20 th century demanded protocol (guidelines) for nephrological activity for all levels of medical care, of doctors and specialists. The International Society of Nephrology, the European Renal Association and other national associations created their own protocol (guidelines) for nephrological activity. The Macedonian Society of Nephrology, Dialysis, Transplantation and Artificial Organs (MSNDTAO) proclaimed the First Protocol for Performing Nephrological Activity in the Republic of Macedonia at the First Congress of the MSNDTAO, held in Ohrid 1993, and it was published in the Macedonian Medical Review, 1994; Supplement 14: 397-406 [1]. The update of the Protocol for Performing Nephrological Activity in the Republic of Macedonia was proclaimed at the Fourth Congress of MSNDTAO, held in Ohrid 2012 and it presented in this text.
- Published
- 2014
- Full Text
- View/download PDF
22. Total dialysate calcium effects on calcium balance during dialysis.
- Author
-
Eftimovska-Otovic N, Babalj-Banskolieva E, Bogdanoska-Kostadinoska S, Milovanceva-Popovska M, and Grozdanovski R
- Subjects
- Female, Humans, Kidney Failure, Chronic blood, Male, Calcium blood, Hemodialysis Solutions chemistry, Kidney Failure, Chronic therapy, Renal Dialysis methods
- Abstract
Introduction: Total dialysate calcium concentration has an important influence on calcium metabolism in bicarbonate high-flux dialysis. The aim of the study is to investigate the influence of different dialysate calcium concentrations on serum concentration of ionised calcium and on the balance of total dialysate calcium., Materials and Methods: A total of 20 stable aneuric patients on chronic bicarbonate high-flux haemodialysis with a frequency of 4 hours, 3 times per week with two different concentrations of total dialysate calcium (tdCa) were included in the study. Dialysis in the first session was performed with total dialysate calcium of 1.25 mmol/L, and at the next session with dialysate calcium of 1.5 mmol/L. The serum concentrations of total and ionized calcium were determined before and after each dialysis session. The balance of total dialysate calcium was measured on the dialysate side., Results: Serum concentration of total calcium before and after haemodialysis did not show any significant difference in HD with a total dialysate calcium of 1.25 mmol/L (2.40 ± 0.19 mmol/L before HD and 2.46 ± 0.15 mmol/L after HD). Serum ionized calcium in HD with tdCa 1.25 significantly decreased after HD (1.16 ± 0.09 mmol/L before HD to 1.08 ± 0.04 mmol/after HD, p < 0.05). The total serum calcium significantly increased after HD in comparison to HD with tdCa of 1.5 mmol/L (2.40 ± 0.15 mmol/L to 2.65 ± 0.16 mmol/L, p < 0.05). The concentration of serum ionized calcium did not increase significantly in HD with tdCa 1.50 mmol/L (1.16 ± 0.08 mmol/L to 1.20 ± 0.05 mmol/L). Average values of total dialysate calcium balance (gradient of diffusion between dialysate and patient) were negative in tdCa 1.25 (1.38 ± 0.08 mmol/L versus 1.48 ± 0.43 mmol/L), but in HD with tdCa 1.5 were slightly positive (1.56 ± 0.07 mmol/L versus 1.52 ± 0.07)., Conclusion: The use of total dialysate calcium of 1.5 mmol/L is beneficial because balance values of total dialysate calcium are slightly positive, but serum concentration of ionized calcium stays in the normal range.
- Published
- 2013
23. Survival of patients on maintenance haemodialysis over a twenty-year period.
- Author
-
Sikole A, Nikolov V, Dzekova P, Stojcev N, Amitov V, Selim G, Asani A, Gelev S, Grozdanovski R, Masin G, Klinkmann H, and Polenakovic M
- Subjects
- Adult, Aged, Female, Humans, Kidney Failure, Chronic mortality, Male, Middle Aged, Survival Analysis, Survival Rate, Kidney Failure, Chronic therapy, Renal Dialysis mortality
- Abstract
Patient survival is a key index of the overall adequacy of treatment in most chronic diseases. Analyses of survival of patients undergoing haemodialysis is very important, as it may offer clues and ideas for prolonging survival of patients with end-stage renal disease (ESRD). The aims of this study were to describe the characteristics of the patients on maintenance haemodialysis therapy over a period of 20 years, to determine the survival rate of these patients according to ages at the onset of haemodialysis, the primary renal diseases, and the cause of death, and to determine the survival rate at five, ten, fifteen and twenty years of haemodialysis treatment at our centre. The charts of 518 unselected patients, 282 male and 236 female, treated with maintenance haemodialysis therapy in a period of 20 years (1985-2005) were reviewed. At the time of evaluation, 164 patients were currently being treated, and 354 patients overall had been diseased. Statistical analysis was performed to evaluate the relationship between survival and patient characteristics such as age, gender, primary renal disease, and age at dialysis onset. Actual survival rates were determined by the Kaplan-Meier method. The survival rate of our patients treated with maintenance haemodialysis was 60% at 5 years, 37% at 10 years, 25% at 15 years and 9% at 20 years. Female patient survival was superior to male. Patients aged under 40 at the start of dialysis had a better survival probability compared to older patients. Patients with diabetes mellitus and nephroangiosclerosis, had a lower survival rate compared to patients with glomerulonephritis and with adult dominant polycystic kidney disease. Cardiac death was the most common cause of death in patients involved in the study. About 52% of the patients died from cardiovascular disease. Death is the most severe consequence of inadequate dialysis and can be used as an index of the adequacy of the dialysis therapy. Treatment factors that may improve outcomes include an early start of dialysis therapy, a high dose of dialysis (Kt/V over 1.2), correction of anemia, adequate protein and caloric intake, control of calcium and phosphate metabolism, and the use of biocompatible dialyzers.
- Published
- 2007
24. Malnutrition inflammation complex syndrome in maintenance haemodialysis patients.
- Author
-
Dzekova P, Nikolov IG, Sikole A, Grozdanovski R, and Polenaković MH
- Subjects
- C-Reactive Protein analysis, Female, Humans, Inflammation, Male, Malnutrition blood, Malnutrition diagnosis, Middle Aged, Serum Albumin analysis, Syndrome, Malnutrition etiology, Renal Dialysis adverse effects
- Abstract
Malnutrition inflammation complex syndrome (MICS) occurs in maintenance haemodialysis (MHD) patients and is a strong predictor of morbidity and mortality in these patients. The aim of our study was to evaluate the influence of inflammation on the biochemical and anthropometrical parameters of the nutritional status in MHD patients. Our study was made on 154 patients (93 men and 61 women, mean age=54.7 yrs. and mean time on dialysis 84 months) over a period of 6 months. The indicator of inflammation, C-reactive protein (CRP), was measured monthly at the central laboratory by nephelometry. The assessment tools used to evaluate the influence of inflammation on the nutritional status in MHD patients were: serum albumin and cholesterol level, midarm circumference (MAC), midarm muscle circumference (MAMC), triceps skin fold thickness (TSF) and body mass index (BMI). Student's t-test was used for group mean comparison between men and women. Person's correlation r was used to determine the significance and the strength of associations. The CRP level was significantly greater in men than in women (12.9 vs. 7.97, p < 0.04). The CRP level showed a strong correlation only with the serum concentration of cholesterol (r=0.49, p < 0.000), and did not correlate with the serum albumin of the MHD patients. There was no correlation between the CRP level and the anthropometrical parameters of the MHD patients in our study. Two separate processes, inflammation and reduced protein intake, each separately contributed to causing a decrease in serum albumin concentration and anthropometrical measurements. The levels of acute phase proteins vary widely as opposed to the serum albumin level; for that reason, changes in the albumin catabolic rate or synthesis require a considerable time to become visible. The average value of the protein catabolic rate of the patients in our study was 1.01 g/kg/d, a value that showed adequate protein intake. These findings would suggest that clinical attention to the maintenance of adequate nutrition could blunt the effects of inflammation on both somatic and visceral protein stores.
- Published
- 2005
25. Histomorphometric analysis of fibrosis in the renal interstitial compartment.
- Author
-
Kostadinova-Kunovska S, Petrusevska G, Jovanović R, Grcvska L, Polenaković M, Dzekova P, Nikolov IG, Sikole A, Grozdanovski R, and Polenaković MH
- Subjects
- Adolescent, Adult, Biopsy, Fibrosis, Humans, Male, Middle Aged, Glomerulonephritis, IGA pathology, Glomerulonephritis, Membranoproliferative pathology, Kidney pathology
- Abstract
The interstitium is the extravascular intertubular space of the renal parenchyma, which provides structural support to the functional renal units and is included at the same time in nearly all renal functions. Alterations to this renal compartment have been found in almost all glomerular diseases. During the last thirty years the studies of a few groups of investigators have shown that the degree of the renal dysfunction is strongly correlated with the changes in the tubulointerstitial compartment. We made a morphometric study of a group of 10 renal biopsies, previously diagnosed as IgA nephropathy or membranoproliferative glomerulonephritis. For morphometric analysis we made colour extraction of the interstitial area on tissue sections stained with trichrom Masson using the LUCIA M-NIKON image analysing system with integrated software for statistical analysis of the data. We measured the surface of the marked fields and the results were expressed as a percentage of the total scanned area. The results were correlated with the serum creatinine at the time of biopsy. We found fibrosis occupying more than 10% of the tubulointerstitial surface in all 10 patients. Six of them had a moderate level of fibrosis, occupying more that 20% of the tubulointerstitial space. The statistical analysis of these results showed a significant correlation between the degree of the interstitial expansion and the serum creatinine. The results showing the correlation between these parameters will enable the quantitative histological analyses to be included in the process of the nephropathological diagnosis in order to evaluate the histological risk factors in glomerular diseases.
- Published
- 2005
26. Short-term effect of folic acid supplementation in renal transplant recipients and chronic kidney disease patients with comparable renal function impairment.
- Author
-
Ivanovski N, Stojceva-Taneva O, Grozdanovski R, Boskovska M, Drueke TB, and Massy ZA
- Subjects
- Adult, Chronic Disease, Female, Folic Acid administration & dosage, Humans, Kidney physiopathology, Kidney Diseases physiopathology, Male, Middle Aged, Folic Acid therapeutic use, Homocysteine blood, Kidney Diseases drug therapy, Kidney Transplantation
- Abstract
Recent evidence suggested that the efficacy of folic acid supplementation in reducing plasma total homocysteine (Hcy) concentration might be similar in renal transplant recipients (RTR) and chronic kidney disease (CKD) patients with a comparable degree of reduction of renal function. However, a direct comparison of the response to high dose folic acid supplementation between renal transplant recipients and CKD patients has never been made. Therefore, the goal of this study was to evaluate the response to folic acid (5 mg/day) supplementation in 15 stable renal transplant recipients with evidence of chronic allograft nephropathy, and in 15 CKD (stage 3) patients matched for age, sex and renal function living in the area of Skopje, Macedonia. After 12 weeks of folic acid supplementation, plasma total Hcy concentrations were significantly reduced in the two groups. Percent reduction of plasma total Hcy levels was nearly identical in the two groups (25.7% vs 24.5%, p = NS). These results confirm previous findings regarding the efficacy of folic acid therapy given separately to either renal transplant recipients or CKD patients, and extend them to a direct confirmation of identical efficacy.
- Published
- 2004
27. Atherosclerosis risk factors related to hemodialysis duration and erythropoietin therapy.
- Author
-
Dejanova B, Filipce V, Dejanov P, Sikole A, Grozdanovski R, and Maleska V
- Subjects
- Adult, Case-Control Studies, Female, Humans, Lipid Peroxidation drug effects, Lipids blood, Male, Middle Aged, Recombinant Proteins, Risk Factors, Time Factors, Triglycerides blood, Arteriosclerosis etiology, Erythropoietin adverse effects, Renal Dialysis adverse effects
- Abstract
Patients undergoing hemodialysis are at risk for atherosclerosis and its complications. The aim of this study was to examine the effect of erythropoietin therapy and hemodialysis duration on some of the atherosclerotis risk factors. The patients were divided into four groups: I: patients undergoing hemodialysis for less than 10 years (n=22); II: patients undergoing hemodialysis for more than 10 years (n=17); III: patients on no erythropoietin (n=21); IV: patients on erythropoeitin therapy (n=18). A control group of 20 subjects was also examined. Triglycerides, total cholesterol, low-density lipoprotein and high-density lipoprotein, lipoprotein(a), apolipoprotein-A1, apolipoprotein-B and lipid peroxidation were examined. There was a significant increase in triglycerides, to 2.59+/-1.2 mmol/l (p<0.001) and in lipid peroxidation in hemodialysis patients, to 5.02+/-0.9 micromol/l vs. controls (p<0.001). Significantly elevated triglycerides and lipid peroxidation levels were found in the patients with longer hemodialysis duration. Triglycerides were elevated in group II vs. group I, to 2.90+/-1.0 mmol/l. (p<0.05). Lipid peroxidation in group II, 5.40+/-1.0 micromol/l, showed significant difference compared to group I (p<0.05). Erythropoietin treatment did not affect any of the examined parameters. These results indicate increased risk for atherosclerosis related to hemodialysis duration. Besides the renal disease itself, hemodialysis may also be one of the risk factors for atherosclerosis.
- Published
- 2001
- Full Text
- View/download PDF
28. Lipids, protein intake, and progression of diabetic nephropathy.
- Author
-
Stojceva-Taneva O, Polenakovic M, Grozdanovski R, and Sikole A
- Subjects
- Diabetes Mellitus, Type 2, Dietary Proteins pharmacology, Disease Progression, Female, Forecasting, Humans, Male, Middle Aged, Prospective Studies, Diabetic Nephropathies physiopathology, Dietary Proteins administration & dosage, Lipids blood
- Published
- 2001
- Full Text
- View/download PDF
29. Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril.
- Author
-
Grcevska L, Polenaković M, Dzikova S, and Grozdanovski R
- Subjects
- Acute Kidney Injury chemically induced, Acute Kidney Injury drug therapy, Adult, Cyclophosphamide therapeutic use, Enalapril therapeutic use, Humans, Kidney pathology, Kidney ultrastructure, Male, Methylprednisolone therapeutic use, Microscopy, Electron, Prednisone therapeutic use, Acute Kidney Injury pathology, Enalapril adverse effects, Kidney Tubules pathology, Nephrosis, Lipoid drug therapy
- Abstract
A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril. Renal biopsy demonstrated minimal glomerular changes with fusion of podocytes, tubular necrosis with regeneration of tubular epithelial cells, interstitial edema with focal interstitial fibrosis, and interstitial infiltration with neutrophils, eosinophils, plasma cells and mononuclear cells. Three hemodialyses were performed in the patient during the oliguric phase of the disease. Renal function was restored after withdrawal of enalapril and initiation of steroid therapy. Steroids also contributed to the improvement of the nephrotic syndrome and proteinuria decreased from maximal ranges of 27 g/l to 2.2 g/l after six months of the follow-up. Similar cases were previously described associated with captopril treatment, but not with enalapril.
- Published
- 1997
30. Long-term diuretic therapy in patients with chronic renal failure.
- Author
-
Cakalaroski K, Ivanovski N, Grozdanovski R, Ristovska V, and Polenakovic M
- Subjects
- Humans, Middle Aged, Time Factors, Diuretics therapeutic use, Furosemide therapeutic use, Kidney Failure, Chronic drug therapy, Polythiazide therapeutic use, Sodium Chloride Symporter Inhibitors therapeutic use
- Abstract
Ten patients with chronic renal failure from different genesis (serum creatinine levels 150-200 mumol/l), were evaluated from the aspect of the effect of the diuretic therapy. The effects of furosemide (FUR) and polythiazide (POL) were assessed after 3-month application. The mean values of the estimated parameters before treatment, after 3-month administration of FUR as a monotherapy and after the next 3 months simultaneously used (FUR + POL), presented a stable increase of the diuresis, without statistically significant changes of the global renal function, and triglyceride disorders. On the contrary, the improvement of calciuria through combined using of furosemide and polythiazide is statistically and clinically significant.
- Published
- 1997
31. [Size of the kidney as an element of clinical evaluation].
- Author
-
Grozdanovski R
- Subjects
- Humans, Kidney pathology, Organ Size, Kidney Diseases diagnosis, Kidney Function Tests methods
- Published
- 1976
32. [Lupus nephritis].
- Author
-
Polenaković M, Grozdanovski R, Dzikova S, and Grcevska L
- Subjects
- Acute Kidney Injury etiology, Adult, Female, Humans, Nephritis complications, Lupus Erythematosus, Systemic complications, Nephritis diagnosis
- Published
- 1977
33. [Renal anemia in relation to the basic pathological status and renal function].
- Author
-
Grozdanovski R
- Subjects
- Humans, Kidney Failure, Chronic diagnosis, Kidney Function Tests methods, Anemia etiology, Kidney Failure, Chronic complications
- Published
- 1976
34. [Hemodialysis and serum hepatitis].
- Author
-
Masin G, Jovanovski J, Cakalaroski K, and Grozdanovski R
- Subjects
- Humans, Kidney Failure, Chronic therapy, Hepatitis B etiology, Renal Dialysis adverse effects
- Published
- 1976
35. [Dialysis--ascites syndrome].
- Author
-
Masin G, Jovanovski J, Cakalarski K, and Grozdanovski R
- Subjects
- Adult, Humans, Kidney Failure, Chronic therapy, Male, Syndrome, Ascites etiology, Renal Dialysis adverse effects
- Published
- 1976
36. [Cardiotonic therapy in nephrology].
- Author
-
Grozdanovski R and Cakalaroski K
- Subjects
- Heart Diseases complications, Humans, Heart Diseases drug therapy, Kidney Diseases complications
- Published
- 1977
37. [Analysis of the composition of patients hospitalized with kidney diseases in a 1-year period].
- Author
-
Hrisoho D, Polenakovik M, and Grozdanovski R
- Subjects
- Acute Disease, Adolescent, Adult, Chronic Disease, Hospitalization, Humans, Kidney Diseases classification, Kidney Diseases diagnosis, Middle Aged, Kidney Diseases therapy
- Published
- 1972
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