Author: "R. Bianchini" - Searchworks@Jio Institute Digital Library Search Results

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180 results on '"R. Bianchini"'

1. Glucocorticoid induced TNFR-related protein (GITR) as marker of human regulatory T cells: expansion of the GITR+CD25- cell subset in patients with systemic lupus erythematosus

Author: E. Bartoloni Bocci, R. Bianchini, O. Bistoni, G. Nocentini, A. Alunno, C. Riccardi, and R. Gerli
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: Objectives: Regulatory T cells (TREG) represent a T cell subset able to modulate immune response by suppressing autoreactive T-lymphocytes. The evidence of a reduced number and an impaired function of this cell population in autoimmune/ inflammatory chronic diseases led to the hypothesis of its involvement in the pathogenesis of these disorders. Glucocorticoid-induced TNFR-related protein (GITR) is a well known marker of murine TREG cells, but little is known in humans. The aim of this study was to investigate the characteristics of TREG cells in systemic lupus erythematosus (SLE) and the potential role of GITR as marker of human TREG. Methods: Nineteen SLE patients and 15 sex- and age-matched normal controls (NC) were enrolled. CD4+ T cells were magnetic sorted from peripheral blood by negative selection. Cell phenotype was analyzed through flow-cytometry using primary and secondary antibodies and real time polymerase-chain reaction (PCR) using TaqMan probes. Results: The CD25highGITRhigh subset was significantly decreased in SLE patients with respect to NC (0.37±0.21% vs 0.72±0.19%; p
Published: 2011
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2. Gezielte Mikronährstoff-Supplementierung in Patientinnen mit Pollenallergie: eine doppelblinde, Placebo-kontrollierte Pilotstudie

Author: S. Jensen, T. Bartosik, S.M. Afify, R. Bianchini, K. Hufnagl, G. Hofstetter, M. Berger, M. Bastl, U. Berger, E. Rivelles, K. Schmetterer, J. Eckl-Dorna, F. Brkic, E. Vyskocil, S. Guethoff, M. Kramer, E. Jensen-Jarolim, and F. Roth-Walter
Published: 2022

3. South American climate reconstruction during the mid-Holocene from an updated paleodata compilation

Author: Ilana Wainer, Iuri Gorenstein, Luciana F. Prado, Paula R. Bianchini, Michael L Griffiths, Francesco SR Pausata, and Elder Yokoyama
Abstract: Investigating the extent and climate implications of the Northern Hemisphere Holocene warm peak that occurred during the mid-Holocene (MH, about 6000 years ago) is of vital interest to better understand and interpret the uncertainties associated with current global warming. Paleoclimate archives are a source of unique indirect measurements, used to characterize past climates. However, several paleo-archives in South America (SA) published before the 2000s have not yet had their derived radiometric ages calibrated, representing a large source of uncertainty in past climate reconstructions. Here we reconstruct eastern SA climate during the MH using 172 paleodata with fully calibrated age models. Our results show that for the MH the Amazon and Southern SA were drier and along the western South Atlantic conditions were saltier compared to present day climate. Southern SA presents warmer than present MH and the region separating Northeast Brazil and Southern SA together with the easternmost part of Northeast Brazil shows divergent behavior, presenting dispersed higher than present rainfall rates.
Published: 2022

4. South American climate reconstruction during the mid-Holocene from an updated paleodata compilation

Author: Wainer, Ilana, primary, Gorenstein, Iuri, additional, F. Prado, Luciana, additional, R. Bianchini, Paula, additional, L Griffiths, Michael, additional, SR Pausata, Francesco, additional, and Yokoyama, Elder, additional
Published: 2022
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5. A fully calibrated and updated mid-Holocene climate reconstruction for Eastern South America

Author: Iuri Gorenstein, Luciana F. Prado, Paula R. Bianchini, Ilana Wainer, Michael L. Griffiths, Francesco S.R. Pausata, and Elder Yokoyama
Subjects: Archeology, Global and Planetary Change, Geology, Ecology, Evolution, Behavior and Systematics
Published: 2022

6. Hormesis, cellular stress response, and redox homeostasis in autism spectrum disorders

Author: Edward J. Calabrese, R. Bianchini, James Giordano, Deja Berritta, Angela Trovato, Maria Laura Ontario, Vittorio Calabrese, and Martino Ruggieri
Subjects: 0301 basic medicine, Hormesis, Cognition, medicine.disease, Neuroprotection, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 030104 developmental biology, chemistry, Autism spectrum disorder, Cellular stress response, medicine, Autism, Psychology, Neuroscience, Neuroinflammation, Sulforaphane
Abstract: In the United States, 1.1-1.5% of children have been diagnosed with autism spectrum disorders (ASD), corresponding to a 30% increase in incidence and prevalence. Social and communication impairments are the main signs and symptoms of ASD, and currently available medications have been ineffective in reducing these core deficits. Observational studies have indicated that children with ASD tend to show improved cognition and behavior after febrile illness, which is associated with alteration of metabolic pathways, leading to cellular stress responses and increased expression of heat shock proteins (Hsps). Sulforaphane and hydroxytyrosol, phytochemicals derived from cruciferous vegetables and extra virgin olive oil, respectively, can induce metabolic effects in cellular stress responses that are similar to those produced by fever. Thus, modulation of endogenous cellular defense mechanisms may be an innovative approach for therapeutic intervention in ASD and other disorders associated with neuroinflammation and neurodegeneration. This Review introduces the hormetic dose-response concept and presents possible mechanisms and applications for neuroprotection. We address the emerging role of Hsps in the neuroprotective network of redox stress-responsive mechanisms and propose the potential therapeutic utility of the nutritional antioxidants sulforaphane and hydroxytyrosol against particular signs and symptoms of ASD. We argue that such research findings must be approached with pragmatism and prudence. It is vital to capitalize on recent and ongoing investments in brain science research and to refine neuroscientific knowledge and capability for more accurate diagnosis and safe, effective, and ethically sound treatment of ASD and other neuropsychiatric spectrum disorders. © 2016 Wiley Periodicals, Inc.
Published: 2016

7. LB946 Improvements in acne-prone skin quality correlate with a reduction in saliva cortisol levels after use of an 8-week 3-step topical regimen

Author: R. Bianchini, Katie Rodan, J.S. Craw, Kathy Fields, C. Skobowiat, and T. Falla
Subjects: Saliva, medicine.medical_specialty, business.industry, medicine.medical_treatment, Cell Biology, Dermatology, medicine.disease, Biochemistry, Regimen, Internal medicine, Medicine, business, Molecular Biology, Cortisol level, Reduction (orthopedic surgery), Acne
Published: 2020

8. Precision measurement of the structure of the CMS inner tracking system using nuclear interactions

Author: Sirunyan, A.M. Tumasyan, A. Adam, W. Ambrogi, F. Asilar, E. Bergauer, T. Brandstetter, J. Brondolin, E. Dragicevic, M. Erö, J. Valle, A.E.D. Flechl, M. Frühwirth, R. Ghete, V.M. Grossmann, J. Hrubec, J. Jeitler, M. König, A. Krammer, N. Krätschmer, I. Liko, D. Madlener, T. Mikulec, I. Rad, N. Rohringer, H. Schieck, J. Schöfbeck, R. Spanring, M. Spitzbart, D. Steininger, H. Taurok, A. Waltenberger, W. Wittmann, J. Wulz, C.-E. Zarucki, M. Chekhovsky, V. Mossolov, V. Gonzalez, J.S. Beaumont, W. Wolf, E.A.D. Croce, D.D. Janssen, X. Lauwers, J. Pieters, M. Klundert, M.V.D. Haevermaet, H.V. Mechelen, P.V. Remortel, N.V. Zeid, S.A. Blekman, F. Bols, E.S. D'Hondt, J. Bruyn, I.D. Clercq, J.D. Deroover, K. Flouris, G. Lontkovskyi, D. Lowette, S. Marchesini, I. Moortgat, S. Moreels, L. Python, Q. Skovpen, K. Tavernier, S. Doninck, W.V. Mulders, P.V. Parijs, I.V. Allard, Y. Beghin, D. Bilin, B. Brun, H. Clerbaux, B. Lentdecker, G.D. Delannoy, H. Dorney, B. Fasanella, G. Favart, L. Goldouzian, R. Grebenyuk, A. Kalsi, A.K. Lenzi, T. Luetic, J. Moureaux, L. Postiau, N. Song, Z. Starling, E. Velde, C.V. Vanlaer, P. Vannerom, D. Wang, Q. Yang, Y. Cornelis, T. Dobur, D. Fagot, A. Gul, M. Khvastunov, I. Poyraz, D. Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. Bakhshiansohi, H. Bondu, O. Brochet, S. Bruno, G. Caputo, C. Caudron, A. David, P. Visscher, S.D. Delaere, C. Delcourt, M. Francois, B. Giammanco, A. Krintiras, G. Lemaitre, V. Magitteri, A. Mertens, A. Michotte, D. Musich, M. Piotrzkowski, K. Quertenmont, L. Saggio, A. Szilasi, N. Marono, M.V. Wertz, S. Zobec, J. Beliy, N. Caebergs, T. Daubie, E. Hammad, G.H. Alves, F.L. Alves, G.A. Brito, L. Silva, G.C. Hensel, C. Moraes, A. Pol, M.E. Teles, P.R. Chagas, E.B.B.D. Carvalho, W. Chinellato, J. Coelho, E. Costa, E.M.D. Silveira, G.G.D. Damiao, D.D.J. Martins, C.D.O. Souza, S.F.D. Malbouisson, H. Figueiredo, D.M. Almeida, M.M.D. Herrera, C.M. Mundim, L. Nogima, H. Silva, W.L.P.D. Rosas, L.J.S. Santoro, A. Sznajder, A. Thiel, M. Manganote, E.J.T. Araujo, F.T.D.S.D. Pereira, A.V. Ahuja, S. Bernardes, C.A. Calligaris, L. Tomei, T.R.F.P. Gregores, E.M. Mercadante, P.G. Novaes, S.F. Padula, S. Abad, D.R. Aleksandrov, A. Hadjiiska, R. Iaydjiev, P. Marinov, A. Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Fang, W. Gao, X. Yuan, L. Ahmad, M. Bian, J.G. Chen, G.M. Chen, H.S. Chen, M. Chen, Y. Jiang, C.H. Leggat, D. Liao, H. Liu, Z. Romeo, F. Shaheen, S.M. Spiezia, A. Tao, J. Wang, C. Wang, Z. Yazgan, E. Zhang, H. Zhao, J. Ban, Y. Chen, G. Li, J. Li, Q. Liu, S. Mao, Y. Qian, S.J. Wang, D. Xu, Z. Wang, Y. Avila, C. Cabrera, A. Montoya, C.A.C. Sierra, L.F.C. Florez, C. Hernández, C.F.G. Delgado, M.A.S. Courbon, B. Godinovic, N. Lelas, D. Puljak, I. Sculac, T. Antunovic, Z. Kovac, M. Brigljevic, V. Ceci, S. Ferencek, D. Kadija, K. Mesic, B. Starodumov, A. Susa, T. Ather, M.W. Attikis, A. Mavromanolakis, G. Mousa, J. Nicolaou, C. Ptochos, F. Razis, P.A. Rykaczewski, H. Finger, M. Finger, M. Ayala, E. Jarrin, E.C. Elgammal, S. Kamel, A.E. Salama, E. Ahmed, I. Bhowmik, S. Oliveira, A.C.A.D. Dewanjee, R.K. Ehataht, K. Kadastik, M. Perrini, L. Raidal, M. Veelken, C. Eerola, P. Kirschenmann, H. Pekkanen, J. Voutilainen, M. Havukainen, J. Heikkilä, J.K. Järvinen, T. Karimäki, V. Kinnunen, R. Lampén, T. Lassila-Perini, K. Laurila, S. Lehti, S. Lindén, T. Luukka, P. Mäenpä, T. Siikonen, H. Tuominen, E. Tuominiemi, J. Tuuva, T. Besancon, M. Couderc, F. Dejardin, M. Denegri, D. Faure, J.L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. De Monchenault, G.H. Jarry, P. Leloup, C. Locci, E. Malcles, J. Negro, G. Rander, J. Rosowsky, A. Sahin, M.Ö. Titov, M. Abdulsalam, A. Amendola, C. Antropov, I. Beaudette, F. Busson, P. Charlot, C. De Cassagnac, R.G. Kucher, I. Lisniak, S. Lobanov, A. Blanco, J.M. Nguyen, M. Ochando, C. Ortona, G. Pigard, P. Salerno, R. Sauvan, J.B. Sirois, Y. Leiton, A.G.S. Yilmaz, Y. Zabi, A. Zghiche, A. Agram, J.-L. Andrea, J. Bloch, D. Bonnin, C. Brom, J.-M. Chabert, E.C. Charles, L. Cherepanov, V. Collard, C. Conte, E. Fontaine, J.-C. Gelé, D. Goerlach, U. Gross, L. Hosselet, J. Jansová, M. Bihan, A.-C.L. Tonon, N. Hove, P.V. Gadrat, S. Baulieu, G. Beauceron, S. Bernet, C. Boudoul, G. Caponetto, L. Chanon, N. Chierici, R. Contardo, D. Depasse, P. Dupasquier, T. Mamouni, H.E. Fay, J. Finco, L. Galbit, G. Gascon, S. Gouzevitch, M. Grenier, G. Ille, B. Lagarde, F. Laktineh, I.B. Lattaud, H. Lethuillier, M. Lumb, N. Mirabito, L. Nodari, B. Pequegnot, A.L. Perries, S. Popov, A. Sordini, V. Donckt, M.V. Viret, S. Zhang, S. Toriashvili, T. Lomidze, D. Autermann, C. Feld, L. Karpinski, W. Kiesel, M.K. Klein, K. Lipinski, M. Ostapchuk, A. Pierschel, G. Preuten, M. Rauch, M.P. Schael, S. Schomakers, C. Schulz, J. Schwering, G. Teroerde, M. Wittmer, B. Wlochal, M. Zhukov, V. Albert, A. Duchardt, D. Endres, M. Erdmann, M. Erdweg, S. Esch, T. Fischer, R. Ghosh, S. Güth, A. Hebbeker, T. Heidemann, C. Hoepfner, K. Knutzen, S. Mastrolorenzo, L. Merschmeyer, M. Meyer, A. Millet, P. Mukherjee, S. Pook, T. Radziej, M. Reithler, H. Rieger, M. Scheuch, F. Schmidt, A. Teyssier, D. Thüer, S. Dziwok, C. Flügge, G. Hlushchenko, O. Kargoll, B. Kress, T. Künsken, A. Müller, T. Nehrkorn, A. Nowack, A. Pistone, C. Pooth, O. Sert, H. Stahl, A. Ziemons, T. Martin, M.A. Arndt, T. Asawatangtrakuldee, C. Babounikau, I. Beernaert, K. Behnke, O. Behrens, U. Martinez, A.B. Bertsche, D. Anuar, A.A.B. Borras, K. Botta, V. Campbell, A. Connor, P. Contreras-Campana, C. Costanza, F. Danilov, V. Wit, A.D. Defranchis, M.M. Pardos, C.D. Damiani, D.D. Eckerlin, G. Eckstein, D. Eichhorn, T. Elwood, A. Eren, E. Gallo, E. Geiser, A. Luyando, J.M.G. Grohsjean, A. Gunnellini, P. Guthoff, M. Hansen, K. Haranko, M. Harb, A. Hauk, J. Jung, H. Kasemann, M. Keaveney, J. Kleinwort, C. Knolle, J. Krücker, D. Lange, W. Lelek, A. Lenz, T. Lipka, K. Lohmann, W. Mankel, R. Maser, H. Melzer-Pellmann, I.-A. Meyer, A.B. Meyer, M. Missiroli, M. Mittag, G. Mnich, J. Muhl, C. Mussgiller, A. Myronenko, V. Pflitsch, S.K. Pitzl, D. Raspereza, A. Reichelt, O. Savitskyi, M. Saxena, P. Schütze, P. Schwanenberger, C. Shevchenko, R. Singh, A. Stefaniuk, N. Tholen, H. Vagnerini, A. Onsem, G.P.V. Walsh, R. Wen, Y. Wichmann, K. Wissing, C. Zenaiev, O. Zuber, A. Aggleton, R. Bein, S. Benecke, A. Biskop, H. Blobel, V. Buhmann, P. Vignali, M.C. Dreyer, T. Ebrahimi, A. Feindt, F. Garutti, E. Gonzalez, D. Haller, J. Hinzmann, A. Hoffmann, M. Karavdina, A. Kasieczka, G. Klanner, R. Kogler, R. Kovalchuk, N. Kurz, S. Kutzner, V. Lange, J. Marconi, D. Matysek, M. Multhaup, J. Niedziela, M. Niemeyer, C.E.N. Nowatschin, D. Perieanu, A. Reimers, A. Rieger, O. Scharf, C. Schleper, P. Schumann, S. Schwandt, J. Sonneveld, J. Stadie, H. Steinbrück, G. Stober, F.M. Stöver, M. Troendle, D. Usai, E. Vanhoefer, A. Vormwald, B. Wellhausen, J. Zoi, I. Abbas, S.M. Akbiyik, M. Ardila, L. Balzer, M. Barth, C. Barvich, T. Baselga, M. Baur, S. Blank, T. Boegelspacher, F. Butz, E. Caselle, M. Caspart, R. Chwalek, T. Colombo, F. Boer, W.D. Dierlamm, A. Morabit, K.E. Faltermann, N. Freund, B. Giffels, M. Harrendorf, M.A. Hartmann, F. Heindl, S.M. Husemann, U. Kassel, F. Katkov, I. Kudella, S. Maier, S. Metzler, M. Mildner, H. Mozer, M.U. Müller, Th. Neufeld, M. Plagge, M. Quast, G. Rabbertz, K. Sander, O. Schell, D. Schröder, M. Schuh, T. Shvetsov, I. Sieber, G. Simonis, H.J. Steck, P. Ulrich, R. Wassmer, M. Wayand, S. Weber, M. Weddigen, A. Weiler, T. Williamson, S. Wöhrmann, C. Wolf, R. Anagnostou, G. Asenov, P. Assiouras, P. Daskalakis, G. Geralis, T. Kyriakis, A. Loukas, D. Paspalaki, G. Topsis-Giotis, I. Karathanasis, G. Kesisoglou, S. Kontaxakis, P. Panagiotou, A. Saoulidou, N. Tziaferi, E. Vellidis, K. Kousouris, K. Papakrivopoulos, I. Tsipolitis, Y. Evangelou, I. Foudas, C. Gianneios, P. Katsoulis, P. Kokkas, P. Mallios, S. Manthos, N. Papadopoulos, I. Paradas, E. Strologas, J. Triantis, F.A. Tsitsonis, D. Csanad, M. Filipovic, N. Major, P. Nagy, M.I. Pasztor, G. Surányi, O. Veres, G.I. Bencze, G. Hajdu, C. Horvath, D. Hunyadi, A. Sikler, F. Vámi, T.Á. Veszpremi, V. Vesztergombi, G. Beni, N. Czellar, S. Karancsi, J. Makovec, A. Molnar, J. Szillasi, Z. Bartók, M. Raics, P. Trocsanyi, Z.L. Ujvari, B. Choudhury, S. Komaragiri, J.R. Bahinipati, S. Mal, P. Mandal, K. Nayak, A. Sahoo, D.K. Swain, S.K. Bansal, S. Beri, S.B. Bhatnagar, V. Chauhan, S. Chawla, R. Dhingra, N. Gupta, R. Kaur, A. Kaur, A. Kaur, M. Kaur, S. Kumar, R. Kumari, P. Lohan, M. Mehta, A. Sharma, S. Singh, J.B. Walia, G. Bhardwaj, A. Choudhary, B.C. Dalal, R. Garg, R.B. Gola, M. Jain, G. Keshri, S. Kumar, A. Malhotra, S. Naimuddin, M. Priyanka, P. Ranjan, K. Shah, A. Sharma, R. Bhardwaj, R. Bharti, M. Bhattacharya, R. Bhattacharya, S. Bhawandeep, U. Bhowmik, D. Dey, S. Dutt, S. Dutta, S. Ghosh, S. Mondal, K. Nandan, S. Purohit, A. Rout, P.K. Roy, A. Chowdhury, S.R. Sarkar, S. Sharan, M. Singh, B. Thakur, S. Behera, P.K. Chudasama, R. Dutta, D. Jha, V. Kumar, V. Netrakanti, P.K. Pant, L.M. Shukla, P. Aziz, T. Bhat, M.A. Dugad, S. Mahakud, B. Mitra, S. Mohanty, G.B. Sur, N. Sutar, B. Banerjee, S. Bhattacharya, S. Chatterjee, S. Das, P. Guchait, M. Jain, S. Kumar, S. Maity, M. Majumder, G. Mazumdar, K. Sahoo, N. Sarkar, T. Chauhan, S. Dube, S. Hegde, V. Kapoor, A. Kothekar, K. Pandey, S. Rane, A. Sharma, S. Chenarani, S. Tadavani, E.E. Etesami, S.M. Khakzad, M. Najafabadi, M.M. Naseri, M. Hosseinabadi, F.R. Safarzadeh, B. Zeinali, M. Felcini, M. Grunewald, M. Abbrescia, M. Calabria, C. Cariola, P. Colaleo, A. Creanza, D. Cristella, L. Filippis, N.D. Palma, M.D. Robertis, G.D. Florio, A.D. Errico, F. Fiore, L. Gelmi, A. Iaselli, G. Lezki, S. Loddo, F. Maggi, G. Maggi, M. Martiradonna, S. Miniello, G. My, S. Nuzzo, S. Pompili, A. Pugliese, G. Radogna, R. Ranieri, A. Selvaggi, G. Sharma, A. Silvestris, L. Venditti, R. Verwilligen, P. Zito, G. Abbiendi, G. Battilana, C. Bonacorsi, D. Borgonovi, L. Braibant-Giacomelli, S. Campanini, R. Capiluppi, P. Castro, A. Cavallo, F.R. Chhibra, S.S. Codispoti, G. Cuffiani, M. Dallavalle, G.M. Fabbri, F. Fanfani, A. Giacomelli, P. Grandi, C. Guiducci, L. Iemmi, F. Marcellini, S. Masetti, G. Montanari, A. Navarria, F.L. Perrotta, A. Rossi, A.M. Rovelli, T. Siroli, G.P. Tosi, N. Albergo, S. Costa, S. Mattia, A.D. Potenza, R. Saizu, M.A. Tricomi, A. Tuve, C. Barbagli, G. Brianzi, M. Chatterjee, K. Ciaranfi, R. Ciulli, V. Civinini, C. D'Alessandro, R. Focardi, E. Latino, G. Lenzi, P. Manolescu, F. Meschini, M. Paoletti, S. Russo, L. Scarlini, E. Sguazzoni, G. Strom, D. Viliani, L. Benussi, L. Bianco, S. Fabbri, F. Piccolo, D. Primavera, F. Ferro, F. Ravera, F. Robutti, E. Tosi, S. Benaglia, A. Beschi, A. Brianza, L. Brivio, F. Ciriolo, V. Guida, S.D. Dinardo, M.E. Fiorendi, S. Gennai, S. Ghezzi, A. Govoni, P. Malberti, M. Malvezzi, S. Manzoni, R.A. Massironi, A. Menasce, D. Moroni, L. Paganoni, M. Pedrini, D. Ragazzi, S. De Fatis, T.T. Zuolo, D. Buontempo, S. Cavallo, N. Crescenzo, A.D. Fabozzi, F. Fienga, F. Galati, G. Iorio, A.O.M. Khan, W.A. Lista, L. Meola, S. Paolucci, P. Sciacca, C. Voevodina, E. Azzi, P. Bacchetta, N. Benato, L. Bisello, D. Boletti, A. Bragagnolo, A. Carlin, R. Checchia, P. Dall'Osso, M. Manzano, P.D.C. Dorigo, T. Dosselli, U. Gasparini, F. Gasparini, U. Gozzelino, A. Lacaprara, S. Lujan, P. Margoni, M. Meneguzzo, A.T. Pozzobon, N. Ronchese, P. Rossin, R. Simonetto, F. Tiko, A. Torassa, E. Zanetti, M. Zotto, P. Zumerle, G. Braghieri, A. Canio, F.D. Gaioni, L. Magnani, A. Manghisoni, M. Montagna, P. Ratti, S.P. Re, V. Ressegotti, M. Riccardi, C. Riceputi, E. Salvini, P. Traversi, G. Vai, I. Vitulo, P. Solestizi, L.A. Biasini, M. Bilei, G.M. Bizzaglia, S. Cecchi, C. Checcucci, B. Ciangottini, D. Fanò, L. Ionica, M. Lariccia, P. Leonardi, R. Manoni, E. Mantovani, G. Marconi, S. Mariani, V. Menichelli, M. Morozzi, A. Moscatelli, F. Passeri, D. Placidi, P. Rossi, A. Santocchia, A. Spiga, D. Storchi, L. Androsov, K. Azzurri, P. Bagliesi, G. Basti, A. Beccherle, R. Bianchini, L. Boccali, T. Borrello, L. Bosi, F. Castaldi, R. Ciocci, M.A. Dell'Orso, R. Fedi, G. Fiori, F. Giannini, L. Giassi, A. Grippo, M.T. Ligabue, F. Magazzu, G. Manca, E. Mandorli, G. Mazzoni, E. Messineo, A. Moggi, A. Morsani, F. Palla, F. Palmonari, F. Raffaelli, F. Rizzi, A. Spagnolo, P. Tenchini, R. Tonelli, G. Venturi, A. Verdini, P.G. Barone, L. Cavallari, F. Cipriani, M. Daci, N. Re, D.D. Marco, E.D. Diemoz, M. Gelli, S. Longo, E. Marzocchi, B. Meridiani, P. Organtini, G. Pandolfi, F. Paramatti, R. Preiato, F. Rahatlou, S. Rovelli, C. Santanastasio, F. Amapane, N. Arcidiacono, R. Argiro, S. Arneodo, M. Bartosik, N. Bellan, R. Biino, C. Cartiglia, N. Cenna, F. Costa, M. Covarelli, R. Dellacasa, G. Demaria, N. Kiani, B. Mariotti, C. Maselli, S. Mazza, G. Migliore, E. Monaco, V. Monteil, E. Monteno, M. Obertino, M.M. Pacher, L. Pastrone, N. Paterno, A. 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Strobbe, N. Taylor, L. Tkaczyk, S. Tran, N.V. Uplegger, L. Vaandering, E.W. Vernieri, C. Verzocchi, M. Vidal, R. Voirin, E. Wang, M. Weber, H.A. Whitbeck, A. Acosta, D. Avery, P. Bortignon, P. Bourilkov, D. Brinkerhoff, A. Cadamuro, L. Carnes, A. Carver, M. Curry, D. Field, R.D. Gleyzer, S.V. Joshi, B.M. Konigsberg, J. Korytov, A. Ma, P. Matchev, K. Mei, H. Mitselmakher, G. Shi, K. Sperka, D. Thomas, L. Wang, J. Wang, S. Joshi, Y.R. Linn, S. Ackert, A. Adams, T. Askew, A. Hagopian, S. Hagopian, V. Johnson, K.F. Kolberg, T. Martinez, G. Perry, T. Prosper, H. Saha, A. Santra, A. Sharma, V. Yohay, R. Baarmand, M.M. Bhopatkar, V. Colafranceschi, S. Hohlmann, M. Noonan, D. Roy, T. Yumiceva, F. Adams, M.R. Apanasevich, L. Berry, D. Betts, R.R. Cavanaugh, R. Chen, X. Dittmer, S. Evdokimov, A. Evdokimov, O. Gerber, C.E. Hangal, D.A. Hofman, D.J. Jung, K. Kamin, J. Macauda, S. Mills, C. Gonzalez, I.D.S. Tonjes, M.B. Varelas, N. Wang, H. Wu, Z. Zhang, J. Alhusseini, M. Bilki, B. Clarida, W. Dilsiz, K. Durgut, S. Gandrajula, R.P. Haytmyradov, M. Khristenko, V. Merlo, J.-P. Mestvirishvili, A. Moeller, A. Nachtman, J. Ogul, H. Onel, Y. Ozok, F. Penzo, A. Rude, C. Snyder, C. Tiras, E. Wetzel, J. Yi, K. Anderson, I. Blumenfeld, B. Cocoros, A. Eminizer, N. Fehling, D. Feng, L. Gritsan, A.V. Hung, W.T. Maksimovic, P. Martin, C. Roskes, J. Sarica, U. Swartz, M. Xiao, M. You, C. Al-Bataineh, A. Baringer, P. Bean, A. Boren, S. Bowen, J. Castle, J. Flowers, Z. Gibson, E. Khalil, S. Kropivnitskaya, A. Majumder, D. McBrayer, W. Murray, M. Rogan, C. Sanders, S. Schmitz, E. Takaki, J.D.T. Wang, Q. Wilson, G. Ivanov, A. Kaadze, K. Maravin, Y. Mendis, D.R. Mitchell, T. Modak, A. Mohammadi, A. Saini, L.K. Skhirtladze, N. Taylor, R. Rebassoo, F. Wright, D. Baden, A. Baron, O. Belloni, A. Eno, S.C. Feng, Y. Ferraioli, C. Hadley, N.J. Jabeen, S. Jeng, G.Y. Kellogg, R.G. Kunkle, J. Mignerey, A.C. Ricci-Tam, F. Shin, Y.H. Skuja, A. Tonwar, S.C. Wong, K. Abercrombie, D. Allen, B. Azzolini, V. Barbieri, R. Baty, A. Bauer, G. Bi, R. Brandt, S. Busza, W. Cali, I.A. D'Alfonso, M. Demiragli, Z. Ceballos, G.G. Goncharov, M. Harris, P. Hsu, D. Hu, M. Iiyama, Y. Innocenti, G.M. Klute, M. Kovalskyi, D. Lee, Y.-J. Levin, A. Luckey, P.D. Maier, B. Marini, A.C. McGinn, C. Mironov, C. Narayanan, S. Niu, X. Paus, C. Roland, C. Roland, G. Stephans, G.S.F. Sumorok, K. Tatar, K. Velicanu, D. Wang, J. Wang, T.W. Wyslouch, B. Zhaozhong, S. Benvenuti, A.C. Chatterjee, R.M. Evans, A. Hansen, P. Kalafut, S. Kubota, Y. Lesko, Z. Mans, J. Nourbakhsh, S. Ruckstuhl, N. Rusack, R. Turkewitz, J. Wadud, M.A. Acosta, J.G. Cremaldi, L.M. Oliveros, S. Perera, L. Summers, D. Avdeeva, E. Bloom, K. Claes, D.R. Fangmeier, C. Golf, F. Suarez, R.G. Kamalieddin, R. Kravchenko, I. Monroy, J. Siado, J.E. Snow, G.R. Stieger, B. Godshalk, A. Harrington, C. Iashvili, I. Kharchilava, A. Nguyen, D. Parker, A. Rappoccio, S. Roozbahani, B. Alverson, G. Barberis, E. Freer, C. Hortiangtham, A. Morse, D.M. Orimoto, T. Lima, R.T.D. Wamorkar, T. Wang, B. Wisecarver, A. Wood, D. Bhattacharya, S. Charaf, O. Hahn, K.A. Mucia, N. Odell, N. Schmitt, M.H. Sevova, S. Sung, K. Trovato, M. Velasco, M. Bucci, R. Dev, N. Hildreth, M. Anampa, K.H. Jessop, C. Karmgard, D.J. Kellams, N. Lannon, K. Li, W. Loukas, N. Marinelli, N. Meng, F. Mueller, C. Musienko, Y. Planer, M. Reinsvold, A. Ruchti, R. Siddireddy, P. Smith, G. Taroni, S. Wayne, M. Wightman, A. Wolf, M. Woodard, A. Alimena, J. Antonelli, L. Bylsma, B. Durkin, L.S. Flowers, S. Francis, B. Hart, A. Hill, C. Ji, W. Ling, T.Y. Luo, W. Winer, B.L. Wulsin, H.W. Cooperstein, S. Elmer, P. Hardenbrook, J. Hebda, P. Higginbotham, S. Kalogeropoulos, A. Lange, D. Luo, J. Marlow, D. Mei, K. Ojalvo, I. Olsen, J. Palmer, C. Piroué, P. Salfeld-Nebgen, J. Stickland, D. Tully, C. Malik, S. Norberg, S. Vargas, J.E.R. Barker, A. Barnes, V.E. Das, S. Gutay, L. Jones, M. Jung, A.W. Khatiwada, A. Miller, D.H. Neumeister, N. Peng, C.C. Qiu, H. Schulte, J.F. Sun, J. Thieman, J. Wang, F. Xiao, R. Xie, W. Cheng, T. Dolen, J. Parashar, N. Chen, Z. Ecklund, K.M. Freed, S. Geurts, F.J.M. Guilbaud, M. Kilpatrick, M. Li, W. Michlin, B. Nussbaum, T. Padley, B.P. Roberts, J. Rorie, J. Shi, W. Tu, Z. Zabel, J. Zhang, A. Betchart, B. Bodek, A. De Barbaro, P. Demina, R. Duh, Y.T. Dulemba, J.L. Fallon, C. Ferbel, T. Galanti, M. Garcia-Bellido, A. Han, J. Hindrichs, O. Khukhunaishvili, A. Lo, K.H. Petrillo, G. Tan, P. Taus, R. Verzetti, M. Agapitos, A. Bartz, E. Chou, J.P. Gershtein, Y. Espinosa, T.A.G. Halkiadakis, E. Heindl, M. Hughes, E. Kaplan, S. Elayavalli, R.K. Kyriacou, S. Lath, A. Montalvo, R. Nash, K. Osherson, M. Saka, H. Salur, S. Schnetzer, S. Sheffield, D. Somalwar, S. Stone, R. Thomas, S. Thomassen, P. Walker, M. Delannoy, A.G. Heideman, J. Riley, G. Rose, K. Spanier, S. Thapa, K. Bouhali, O. Hernandez, A.C. Celik, A. Dalchenko, M. Mattia, M.D. Delgado, A. Dildick, S. Eusebi, R. Gilmore, J. Huang, T. Kamon, T. Mueller, R. Osipenkov, I. Pakhotin, Y. Patel, R. Perloff, A. Perniè, L. Rathjens, D. Safonov, A. Tatarinov, A. Akchurin, N. Damgov, J. Guio, F.D. Dudero, P.R. Faulkner, J. Kunori, S. Lamichhane, K. Lee, S.W. Mengke, T. Muthumuni, S. Peltola, T. Undleeb, S. Volobouev, I. Wang, Z. D'Angelo, P. Greene, S. Gurrola, A. Janjam, R. Johns, W. Maguire, C. Melo, A. Ni, H. Padeken, K. Alvarez, J.D.R. Sheldon, P. Tuo, S. Velkovska, J. Xu, Q. Arenton, M.W. Barria, P. Cox, B. Hirosky, R. Joyce, M. Ledovskoy, A. Li, H. Neu, C. Sinthuprasith, T. Wang, Y. Wolfe, E. Xia, F. Harr, R. Karchin, P.E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Brodski, M. Buchanan, J. Caillol, C. Carlsmith, D. Dasu, S. Dodd, L. Duric, S. Gomber, B. Grothe, M. Herndon, M. Hervé, A. Hussain, U. Klabbers, P. Lanaro, A. Levine, A. Long, K. Loveless, R. Maurisset, A. Ruggles, T. Savin, A. Smith, N. Smith, W.H. Woods, N.
Subjects: Physics::Instrumentation and Detectors, Physics::Accelerator Physics, High Energy Physics::Experiment, Nuclear Experiment
Abstract: The structure of the CMS inner tracking system has been studied using nuclear interactions of hadrons striking its material. Data from proton-proton collisions at a center-of-mass energy of 13 TeV recorded in 2015 at the LHC are used to reconstruct millions of secondary vertices from these nuclear interactions. Precise positions of the beam pipe and the inner tracking system elements, such as the pixel detector support tube, and barrel pixel detector inner shield and support rails, are determined using these vertices. These measurements are important for detector simulations, detector upgrades, and to identify any changes in the positions of inactive elements. © 2018 CERN for the benefit of the CMS collaboration.
Published: 2018

9. 860 Evaluation of topical dermatologics containing L-ascorbic acid and its esters on Melanoderm™

Author: C. Crane, C. Skobowiat, R. Bianchini, C. Mahon, T. Oswald, T. Falla, and O. Dueva-Koganov
Subjects: Chromatography, Chemistry, Dermatologics, Cell Biology, Dermatology, Ascorbic acid, Molecular Biology, Biochemistry
Published: 2019

10. 859 Evaluation of Kojic Acid and Hydroquinone on Melanoderm™ skin model as controls in screening architecture for skin lightening actives and formulas

Author: C. Mahon, O. Dueva-Koganov, Kathy Fields, R. Bianchini, T. Falla, Katie Rodan, C. Crane, and C. Skobowiat
Subjects: chemistry.chemical_compound, Chromatography, chemistry, Hydroquinone, Cell Biology, Dermatology, Kojic acid, Molecular Biology, Biochemistry
Published: 2019

11. Managing annealing pattern effects in 45nm low power CMOS technology

Author: Pierre Morin, Remi Beneyton, Alexandre Villaret, A. Colin, H. Bono, Florian Cacho, B. Dumont, R. Bianchini, and Emmanuel Josse
Subjects: Materials science, business.industry, Annealing (metallurgy), Electronic packaging, Condensed Matter Physics, Laser, Electronic, Optical and Magnetic Materials, law.invention, CMOS, law, Low-power electronics, MOSFET, Dispersion (optics), Materials Chemistry, Electronic engineering, Optoelectronics, Wafer, Electrical and Electronic Engineering, business
Abstract: Device variability observed at intra-die scale is becoming more and more critical in recent CMOS technologies. This paper presents a study of the across die temperature dispersion induced by the interactions between the annealing processes and non-homogeneous designs patterned at the wafer surface. These phenomena, traditionally called patterned effects, are responsible for significant intra-die device dispersion. A complete optical and thermal simulation methodology that provides the intra-field temperature mapping has been developed and validated by electrical measurement to study these dispersions. This method has been used to quantify the variability induced by both the spike and laser activation anneals implemented in low power 45 nm CMOS platform. It was demonstrated first that the temperature fluctuations induced by the spike process are caused by non-uniform pattern layouts at the die scale. In particular, standard CMP dummy structures used to tile empty areas were found to be inadequate to avoid spike induced pattern effects. In addition, this simulation package proved that laser induced pattern effects are linked to layout inhomogeneities at a shorter scale because of a reduced heat diffusion length during this process. The spatial temperature dispersion phenomena were improved, at first, by decreasing the spatial optical dispersion through the optimization of dummy shapes and tiling (at long and short scale) close to the sensitive devices. The use of an absorbent layer in combination with the laser anneal was also investigated to minimize the spatial optical dispersion effects. A significant effort was carried out as well to reduce the temperature sensitivity of the most critical devices. Working in parallel in these two ways enabled us to suppress the intra-field device variability caused by the annealing pattern effects.
Published: 2010

12. Investigation of Pattern Effects in Rapid Thermal Processing Technology: Modeling and Experimental Results

Author: H. Bono, Remi Beneyton, Florian Cacho, Vincent Fiori, Alexis Colin, Pierre Morin, B. Dumont, and R. Bianchini
Subjects: Materials science, business.industry, Semiconductor device modeling, Condensed Matter Physics, Engineering physics, Industrial and Manufacturing Engineering, Electronic, Optical and Magnetic Materials, Temperature gradient, Rapid thermal processing, Thermal, Emissivity, Radiative transfer, Optoelectronics, Wafer, Electrical and Electronic Engineering, business, Thermal analysis
Abstract: During rapid thermal processing, nonuniformity of local radiative properties in the wafer front side is now obviously identified to results in thermal dispersion at die scale. This leads to changes in annealing temperature and thus variabilities of electrical behavior and device performances. However, these detrimental contributors remain a hard job to manage. Indeed, both optical and thermal physics are involved, a wide range of scales plays role, and many modeling challenges must be faced to understand and solve such issues. In this study, absorptivity and emissivity of various periodic patterned structures are investigated by optical modeling. It is clearly demonstrated that diffraction plays an important role when gate width dimension or space between gates become small. Then, the radiative properties can be mapped at die scale and hence a thermal simulation can be performed. Our intra-die simulated thermal gradient is in good agreement with experimental results.
Published: 2010

13. Influence of pH and Salt on the Photocrosslinking in Polyelectrolyte Thymine‐Containing Films

Author: John C. Warner, Debora Marcela Martino, Jason R. Bianchini, Ramya Kumar, Sofia Trakhtenberg, and Savin Thor
Subjects: Green chemistry, chemistry.chemical_classification, Polymers and Plastics, Chemistry, Otras Ciencias Químicas, Radiation dose, Ciencias Químicas, Salt (chemistry), General Chemistry, Polymer, Polyelectrolyte, Thymine, chemistry.chemical_compound, Chemical engineering, Photosensitivity, Ionic strength, Polymer chemistry, Materials Chemistry, Ceramics and Composites, CIENCIAS NATURALES Y EXACTAS
Abstract: Photocrosslinking of thymine‐based water‐soluble polymer films was investigated at varying preparation conditions. Adding salt or decreasing the pH of the solution from which the films were cast resulted in the decreased efficiency of photoimmobilization, while increasing the pH was found to increase the photoimmobilization efficiency. A mechanistic rationale for the observed effects is proposed. Fil: Trakhtenberg, Sofia. University of Massachusetts Lowell; Estados Unidos Fil: Kumar, Ramya. University of Massachusetts Lowell; Estados Unidos Fil: Bianchini, Jason. University of Massachusetts Lowell; Estados Unidos Fil: Thor, Savin. University of Massachusetts Lowell; Estados Unidos Fil: Martino, Debora Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. University of Massachusetts Lowell; Estados Unidos Fil: Warner, John. University of Massachusetts Lowell; Estados Unidos
Published: 2007

14. M24-Hour Ambulatory Blood Pressure Monitoring in a Cohort of Paediatric Obese Subjects: Diagnostic Option and Clinical Feasibility

Author: A. Alterio, Massimo Volpe, Giuliano Tocci, Sebastiano Sciarretta, R. Bianchini, G. M. Ciavarella, Melania Evangelisti, A. Macari, L. De Biase, Andrea Ferrucci, and Maria Pia Villa
Subjects: medicine.medical_specialty, Ambulatory blood pressure, Pharmacotherapy, business.industry, Cohort, Emergency medicine, Internal Medicine, Medicine, Obese subjects, Cardiology and Cardiovascular Medicine, business
Published: 2007

15. Impact of Different Remodeling Patterns of the Left Ventricle on Indexes of Systolic Performance and Function in Hypertensive Patients with Preserved Ejection Fraction

Author: Sebastiano Sciarretta, A. Alterio, L. De Biase, Andrea Ferrucci, Maria Pia Villa, Filomena Ianniello, Massimo Volpe, A. Macari, Giuliano Tocci, G. M. Ciavarella, and R. Bianchini
Subjects: medicine.medical_specialty, business.industry, symbols.namesake, Pharmacotherapy, Internal medicine, Cohort, Internal Medicine, Cardiology, symbols, Medicine, Diastolic function, Obese subjects, Radiology, Cardiology and Cardiovascular Medicine, business, Doppler effect
Published: 2007

16. A 55 nm triple gate oxide 9 metal layers SiGe BiCMOS technology featuring 320 GHz fT / 370 GHz fMAX HBT and high-Q millimeter-wave passives

Author: S. Joblot, C. De-Buttet, Sébastien Petitdidier, F. Abbate, C. Jenny, Didier Celi, B. Ramadout, Thomas Quemerais, Sebastien Haendler, Laurent Favennec, Daniel Gloria, O. Robin, C. Richard, E. Canderle, B. Borot, K. Haxaire, N. Derrier, Remi Beneyton, Julien Rosa, G. Ribes, O. Saxod, P. Brun, Y. Campidelli, Pascal Chevalier, Cedric Durand, A. Montagne, Francois Leverd, G. Imbert, Olivier Gourhant, M. Guillermet, E. Gourvest, L. Berthier, Clement Tavernier, J. Cossalter, M. Buczko, C. Deglise, Mickael Gros-Jean, C. Julien, Jean-Damien Chapon, K. Courouble, D. Ney, G. Avenier, Patrick Maury, Y. Carminati, R. Bianchini, and F. Foussadier
Subjects: Bit cell, Materials science, business.industry, Heterojunction bipolar transistor, Electrical engineering, Ring oscillator, BiCMOS, Inductor, law.invention, Capacitor, CMOS, law, Extremely high frequency, Optoelectronics, business
Abstract: This paper presents the first 55 nm SiGe BiCMOS technology developed on a 300 mm wafer line in STMicroelectronics. The technology features Low Power (LP) and General Purpose (GP) CMOS devices and 0.45 µm2 6T-SRAM bit cell. High Speed (HS) HBT exhibits 320 GHz f T and 370 GHz f MAX associated with a CML ring oscillator gate delay τ D of 2.34 ps. Transmission lines, capacitors, high-Q varactors and inductors dedicated to millimeter-wave applications are also available.
Published: 2014

17. ADOPTED PRACTICES FOR THE DISPOSAL OF DRUG WASTE AND SANITARY HOUSEHOLD PRODUCTS BY THE HIGH SCHOOL STUDENTS.

Author: L., Agostinetto, V. G. C., Coelho, H. S., Oliveira, J. R., Bianchini, G. W., Silva, V. A., Lima, V., Godoy, R. D., Alves, L. C. K., Trombetta, S. M., Alves, and A. E., Siegloch
Subjects: DRUG disposal, HOME furnishings, HIGH school students, WASTE management, RODENTICIDES, BIOREMEDIATION, VOCATIONAL high schools
Abstract: Copyright of Evidência is the property of Evidencia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2019
Full Text: View/download PDF

18. Methylene Blue Adsorption on Thymine Based Polyvinylphenylsulfonate Films

Author: John C. Warner, Sofia Trakhtenberg, Jason R. Bianchini, and Cecilia Kiarie
Subjects: chemistry.chemical_classification, Aqueous solution, Polymers and Plastics, Cationic polymerization, macromolecular substances, General Chemistry, Polymer, Photoresist, Photochemistry, Thymine, chemistry.chemical_compound, chemistry, Polymer chemistry, Materials Chemistry, Ceramics and Composites, Copolymer, Methylene blue, Curing (chemistry)
Abstract: The immobilization of thymine‐containing copolymers of vinylphenylsulfonate (VPS) and vinylbenzylthymine (VBT) on a nonreactive substrate has been investigated. These polymers are environmentally benign, water‐soluble and when irradiated with low levels of UV light undergo a 2π+2π photodimerization reaction of the thymine moieties. These photoinduced dimers form a crosslinked network that renders the polymer significantly less soluble in water. Consequently the irradiated polymer is immobilized on the substrate, allowing removal of unexposed regions by simple aqueous wash. Visualization of the photoresist is done by “toning” the remaining anionic copolymer with the cationic dye methylene blue. By evaluating the color density of the crosslinked, toned films by UV‐Vis spectroscopy, this report describes the impact of copolymer composition and curing conditions on polymer photoreactivity. Mechanistic rationale is proposed.
Published: 2005

19. 14nm FDSOI technology for high speed and energy efficient applications

Author: B. Le-Gratiet, G. Druais, Denis Rideau, Marie-Anne Jaud, J.-D. Chapon, D. Hoguet, M. Mellier, L. Babaud, Clement Pribat, Emmanuel Josse, D. Barge, S. Puget, J. Mazurier, L. Grenouillet, Nicolas Loubet, S. Zoll, Thierry Poiroux, Jerome Simon, S.P. Fetterolf, M. Bidaud, S. Chhun, M. Vinet, Quanwei Liu, R. Bianchini, E. Bernard, J.-F. Kruck, X. Gerard, C. Gaumer, A. Pofelski, Francois Andrieu, Mustapha Rafik, Olivier Weber, N. Guillot, Pascal Gouraud, F. Abbate, O. Faynot, N. Degors, Olivier Gourhant, Antoine Cros, L. Parmigiani, E. Petitprez, J. Lacord, Patrick Scheer, C. Monget, Michel Haond, Evelyne Richard, P. Maury, Bruce B. Doris, M. Celik, Daniel Benoit, Frederic Monsieur, E. Baylac, L. Clément, S. Lagrasta, Magali Gregoire, J.-P. Manceau, S. Lasserre, P. Perreau, P. Brun, C. Gallon, V. Beugin, Remi Beneyton, Eric Perrin, S. Delmedico, and R. Bingert
Subjects: Very-large-scale integration, business.industry, Computer science, Transistor, Electrical engineering, law.invention, law, Logic gate, MOSFET, Dynamic demand, Electronic engineering, Static random-access memory, business, Electrical efficiency, Efficient energy use
Abstract: This paper presents a 14nm technology designed for high speed and energy efficient applications using strain-engineered FDSOI transistors. Compared to the 28nm FDSOI technology, this 14nm FDSOI technology provides 0.55× area scaling and delivers a 30% speed boost at the same power, or a 55% power reduction at the same speed, due to an increase in drive current and low gate-to-drain capacitance. Using forward back bias (FBB) we experimentally demonstrate that the power efficiency of this technology provides an additional 40% dynamic power reduction for ring oscillators working at the same speed. Finally, a full single-port SRAM offering is reported, including an 0.081°m 2 high-density bitcell and two 0.090°m 2 bitcell flavors used to address high performance and low leakage-low Vmin requirements.
Published: 2014

20. Alignment of the CMS tracker with LHC and cosmic ray data

Author: The CMS collaboration Chatrchyan, S. Khachatryan, V. Sirunyan, A.M. Tumasyan, A. Adam, W. Bergauer, T. Dragicevic, M. Erö, J. Fabjan, C. Friedl, M. Frühwirth, R. Ghete, V.M. Hartl, C. Hörmann, N. Hrubec, J. Jeitler, M. Kiesenhofer, W. Knünz, V. Krammer, M. Krätschmer, I. Liko, D. Mikulec, I. Rabady, D. Rahbaran, B. Rohringer, H. Schöfbeck, R. Strauss, J. Taurok, A. Treberer-Treberspurg, W. Waltenberger, W. Wulz, C.-E. Mossolov, V. Shumeiko, N. Suarez Gonzalez, J. Alderweireldt, S. Bansal, M. Bansal, S. Beaumont, W. Cornelis, T. De Wolf, E.A. Janssen, X. Knutsson, A. Luyckx, S. Mucibello, L. Ochesanu, S. Roland, B. Rougny, R. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Van Spilbeeck, A. Blekman, F. Blyweert, S. D’Hondt, J. Devroede, O. Heracleous, N. Kalogeropoulos, A. Keaveney, J. Kim, T.J. Lowette, S. Maes, M. Olbrechts, A. Python, Q. Strom, D. Tavernier, S. Van Doninck, W. Van Lancker, L. Van Mulders, P. Van Onsem, G.P. Villella, I. Caillol, C. Clerbaux, B. De Lentdecker, G. Favart, L. Gay, A.P.R. Léonard, A. Marage, P.E. Mohammadi, A. Perniè, L. Reis, T. Seva, T. Thomas, L. Vander Velde, C. Vanlaer, P. Wang, J. Adler, V. Beernaert, K. Benucci, L. Cimmino, A. Costantini, S. Dildick, S. Garcia, G. Klein, B. Lellouch, J. Mccartin, J. Ocampo Rios, A.A. Ryckbosch, D. Salva Diblen, S. Sigamani, M. Strobbe, N. Thyssen, F. Tytgat, M. Walsh, S. Yazgan, E. Zaganidis, N. Basegmez, S. Beluffi, C. Bruno, G. Castello, R. Caudron, A. Ceard, L. Da Silveira, G.G. De Callatay, B. Delaere, C. du Pree, T. Favart, D. Forthomme, L. Giammanco, A. Hollar, J. Jez, P. Komm, M. Lemaitre, V. Liao, J. Michotte, D. Militaru, O. Nuttens, C. Pagano, D. Pin, A. Piotrzkowski, K. Popov, A. Quertenmont, L. Selvaggi, M. Vidal Marono, M. Vizan Garcia, J.M. Beliy, N. Caebergs, T. Daubie, E. Hammad, G.H. Alves, G.A. Correa Martins Junior, M. Martins, T. Pol, M.E. Souza, M.H.G. Aldá Júnior, W.L. Carvalho, W. Chinellato, J. Custódio, A. Da Costa, E.M. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Malbouisson, H. Malek, M. Matos Figueiredo, D. Mundim, L. Nogima, H. Prado Da Silva, W.L. Santaolalla, J. Santoro, A. Sznajder, A. Tonelli Manganote, E.J. Vilela Pereira, A. Bernardes, C.A. Dias, F.A. Fernandez Perez Tomei, T.R. Gregores, E.M. Mercadante, P.G. Novaes, S.F. Padula, S.S. Genchev, V. Iaydjiev, P. Marinov, A. Piperov, S. Rodozov, M. Sultanov, G. Vutova, M. Dimitrov, A. Glushkov, I. Hadjiiska, R. Kozhuharov, V. Litov, L. Pavlov, B. Petkov, P. Bian, J.G. Chen, G.M. Chen, H.S. Chen, M. Du, R. Jiang, C.H. Liang, D. Liang, S. Meng, X. Plestina, R. Tao, J. Wang, X. Wang, Z. Asawatangtrakuldee, C. Ban, Y. Guo, Y. Li, Q. Li, W. Liu, S. Mao, Y. Qian, S.J. Wang, D. Zhang, L. Zou, W. Avila, C. Carrillo Montoya, C.A. Chaparro Sierra, L.F. Florez, C. Gomez, J.P. Gomez Moreno, B. Sanabria, J.C. Godinovic, N. Lelas, D. Polic, D. Puljak, I. Antunovic, Z. Kovac, M. Brigljevic, V. Kadija, K. Luetic, J. Mekterovic, D. Morovic, S. Tikvica, L. 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Holzner, A. Kelley, R. Kovalskyi, D. Lebourgeois, M. Letts, J. Macneill, I. Padhi, S. Palmer, C. Pieri, M. Sani, M. Sharma, V. Simon, S. Sudano, E. Tadel, M. Tu, Y. Vartak, A. Wasserbaech, S. Würthwein, F. Yagil, A. Yoo, J. Barge, D. Campagnari, C. Danielson, T. Flowers, K. Geffert, P. George, C. Golf, F. Incandela, J. Justus, C. Kyre, S. Magaña Villalba, R. Mccoll, N. Mullin, S.D. Pavlunin, V. Richman, J. Rossin, R. Stuart, D. To, W. West, C. White, D. Apresyan, A. Bornheim, A. Bunn, J. Chen, Y. Di Marco, E. Duarte, J. Kcira, D. Mott, A. Newman, H.B. Pena, C. Rogan, C. Spiropulu, M. Timciuc, V. Wilkinson, R. Xie, S. Zhu, R.Y. Azzolini, V. Calamba, A. Carroll, R. Ferguson, T. Iiyama, Y. Jang, D.W. Paulini, M. Russ, J. Vogel, H. Vorobiev, I. Cumalat, J.P. Drell, B.R. Ford, W.T. Gaz, A. Luiggi Lopez, E. Nauenberg, U. Smith, J.G. Stenson, K. Ulmer, K.A. Wagner, S.R. Alexander, J. Chatterjee, A. Eggert, N. Gibbons, L.K. Hopkins, W. Khukhunaishvili, A. Kreis, B. Mirman, N. Nicolas Kaufman, G. Patterson, J.R. Ryd, A. Salvati, E. Sun, W. Teo, W.D. Thom, J. Thompson, J. Tucker, J. Weng, Y. Winstrom, L. Wittich, P. Winn, D. Abdullin, S. Albrow, M. Anderson, J. Apollinari, G. Bauerdick, L.A.T. Beretvas, A. Berryhill, J. Bhat, P.C. Burkett, K. Butler, J.N. Chetluru, V. Cheung, H.W.K. Chlebana, F. Chramowicz, J. Cihangir, S. Cooper, W. Deptuch, G. Derylo, G. Elvira, V.D. Fisk, I. Freeman, J. Gao, Y. Gingu, V.C. Gottschalk, E. Gray, L. Green, D. Grünendahl, S. Gutsche, O. Hare, D. Harris, R.M. Hirschauer, J. Hoff, J.R. Hooberman, B. Howell, J. Hrycyk, M. Jindariani, S. Johnson, M. Joshi, U. Kaadze, K. Klima, B. Kwan, S. Lei, C.M. Linacre, J. Lincoln, D. Lipton, R. Liu, T. Los, S. Lykken, J. Maeshima, K. Marraffino, J.M. Martinez Outschoorn, V.I. Maruyama, S. Mason, D. Matulik, M.S. McBride, P. Mishra, K. Mrenna, S. Musienko, Y. Nahn, S. Newman-Holmes, C. O’Dell, V. Prokofyev, O. Prosser, A. Ratnikova, N. Rivera, R. Sexton-Kennedy, E. Sharma, S. Spalding, W.J. Spiegel, L. Taylor, L. Tkaczyk, S. Tran, N.V. Trimpl, M. Uplegger, L. Vaandering, E.W. Vidal, R. Voirin, E. Whitbeck, A. Whitmore, J. Wu, W. Yang, F. Yun, J.C. Acosta, D. Avery, P. Bourilkov, D. Cheng, T. Das, S. De Gruttola, M. Di Giovanni, G.P. Dobur, D. Field, R.D. Fisher, M. Fu, Y. Furic, I.K. Hugon, J. Kim, B. Konigsberg, J. Korytov, A. Kropivnitskaya, A. Kypreos, T. Low, J.F. Matchev, K. Milenovic, P. Mitselmakher, G. Muniz, L. Rinkevicius, A. Shchutska, L. Skhirtladze, N. Snowball, M. Yelton, J. Zakaria, M. Gaultney, V. Hewamanage, S. Linn, S. Markowitz, P. Martinez, G. Rodriguez, J.L. Adams, T. Askew, A. Bochenek, J. Chen, J. Diamond, B. Haas, J. Hagopian, S. Hagopian, V. Johnson, K.F. Prosper, H. Veeraraghavan, V. Weinberg, M. Baarmand, M.M. Dorney, B. Hohlmann, M. Kalakhety, H. Yumiceva, F. Adams, M.R. Apanasevich, L. Bazterra, V.E. Betts, R.R. Bucinskaite, I. Cavanaugh, R. Evdokimov, O. Gauthier, L. Gerber, C.E. Hofman, D.J. Kapustka, B. Khalatyan, S. Kurt, P. Moon, D.H. 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Bauer, G. Busza, W. Cali, I.A. Chan, M. Di Matteo, L. Dutta, V. Gomez Ceballos, G. Goncharov, M. Gulhan, D. Klute, M. Lai, Y.S. Lee, Y.-J. Levin, A. Luckey, P.D. Ma, T. Paus, C. Ralph, D. Roland, C. Roland, G. Stephans, G.S.F. Stöckli, F. Sumorok, K. Velicanu, D. Veverka, J. Wyslouch, B. Yang, M. Yoon, A.S. Zanetti, M. Zhukova, V. Dahmes, B. De Benedetti, A. Gude, A. Kao, S.C. Klapoetke, K. Kubota, Y. Mans, J. Pastika, N. Rusack, R. Singovsky, A. Tambe, N. Turkewitz, J. Acosta, J.G. Cremaldi, L.M. Kroeger, R. Oliveros, S. Perera, L. Rahmat, R. Sanders, D.A. Summers, D. Avdeeva, E. Bloom, K. Bose, S. Claes, D.R. Dominguez, A. Fangmeier, C. Gonzalez Suarez, R. Keller, J. Knowlton, D. Kravchenko, I. Lazo-Flores, J. Malik, S. Meier, F. Monroy, J. Snow, G.R. Dolen, J. George, J. Godshalk, A. Iashvili, I. Jain, S. Kaisen, J. Kharchilava, A. Kumar, A. Rappoccio, S. Alverson, G. Barberis, E. Baumgartel, D. Chasco, M. Haley, J. Massironi, A. Nash, D. Orimoto, T. Trocino, D. Wood, D. Zhang, J. Anastassov, A. Hahn, K.A. Kubik, A. Lusito, L. Mucia, N. Odell, N. Pollack, B. Pozdnyakov, A. Schmitt, M. Sevova, S. Stoynev, S. Sung, K. Trovato, M. Velasco, M. Won, S. Berry, D. Brinkerhoff, A. Chan, K.M. Drozdetskiy, A. Hildreth, M. Jessop, C. Karmgard, D.J. Kellams, N. Kolb, J. Lannon, K. Luo, W. Lynch, S. Marinelli, N. Morse, D.M. Pearson, T. Planer, M. Ruchti, R. Slaunwhite, J. Valls, N. Wayne, M. Wolf, M. Woodard, A. Antonelli, L. Bylsma, B. Durkin, L.S. Flowers, S. Hill, C. Hughes, R. Kotov, K. Ling, T.Y. Puigh, D. Rodenburg, M. Smith, G. Vuosalo, C. Winer, B.L. Wolfe, H. Wulsin, H.W. Berry, E. Elmer, P. Halyo, V. Hebda, P. Hegeman, J. Hunt, A. Jindal, P. Koay, S.A. Lujan, P. Marlow, D. Medvedeva, T. Mooney, M. Olsen, J. Piroué, P. Quan, X. Raval, A. Saka, H. Stickland, D. Tully, C. Werner, J.S. Zenz, S.C. Zuranski, A. Brownson, E. Lopez, A. Mendez, H. Ramirez Vargas, J.E. Alagoz, E. Arndt, K. Benedetti, D. Bolla, G. Bortoletto, D. Bubna, M. Cervantes, M. De Mattia, M. 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Sakharov, A. Sarangi, T. Savin, A. Smith, W.H.
Abstract: The central component of the CMS detector is the largest silicon tracker ever built. The precise alignment of this complex device is a formidable challenge, and only achievable with a significant extension of the technologies routinely used for tracking detectors in the past. This article describes the full-scale alignment procedure as it is used during LHC operations. Among the specific features of the method are the simultaneous determination of up to 200 000 alignment parameters with tracks, the measurement of individual sensor curvature parameters, the control of systematic misalignment effects, and the implementation of the whole procedure in a multi-processor environment for high execution speed. Overall, the achieved statistical accuracy on the module alignment is found to be significantly better than 10μm.© CERN 2014 for the benefit of the CMS collaboration..
Published: 2014

21. Evaluation of procedures for backcalculation of airfield pavement moduli

Author: Priddy, Lucy P.; Gonzalez, Carlos R.; Bianchini, Alessandra; Dossett, Cayce S., United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Geotechnical and Structures Laboratory (U.S.); Air Force Engineering and Services Center (U.S.), Priddy, Lucy P.; Gonzalez, Carlos R.; Bianchini, Alessandra; Dossett, Cayce S., and United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Geotechnical and Structures Laboratory (U.S.); Air Force Engineering and Services Center (U.S.)
Abstract: ERDC/GSL TR-15-31 Evaluation of Procedures for Backcalculation of Airfield Pavement Moduli Geotechnical and Structures Laboratory Lucy P. Priddy, Alessandra Bianchini, Carlos R. Gonzalez, and Cayce S. Dossett August 2015 Approved for public release; distribution is unlimited. The U.S. Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges. ERDC develops innovative solutions in civil and military engineering, geospatial sciences, water resources, and environmental sciences for the Army, the Department of Defense, civilian agencies, and our nation’s public good. Find out more at www.erdc.usace.army.mil. To search for other technical reports published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. ERDC/GSL TR-15-31 August 2015 Evaluation of Procedures for Backcalculation of Airfield Pavement Moduli Lucy P. Priddy and Carlos R. Gonzalez Geotechnical and Structures Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry Road Vicksburg, MS 39180-6199 Alessandra Bianchini 139 Barnes Drive, Suite 1 Air Force Civil Engineer Center Tyndall Air Force Base, FL 32403-5319 Cayce S. Dossett U.S. Air Force Academy 2304 Cadet Drive Suite 3100 U.S. Air Force Academy, CO 80840-5016 Final report Approved for public release; distribution is unlimited. Prepared for Headquarters, Air Force Civil Engineer Center Tyndall Air Force Base, FL 32403-5319 ERDC/GSL TR-15-31 ii Abstract During the period October 2013 through August 2014, research was conducted at the U.S. Army Engineer Research and Development Center (ERDC) in Vicksburg, MS, to improve the U.S. Air Force’s (USAF’s) airfield pavement structural evaluation procedures. Determining the structural integrity of airfield pavement relies on the analysis of pavement deflection data collected using the falling weight deflectometer (FWD) or heavy weight deflectometer (HWD). These deflection data are used to backcalc
Published: 2015

22. Impact of local back biasing on performance in hybrid FDSOI/bulk high-k/metal gate low power (LP) technology

Author: Nicolas Planes, J. Pradelle, Pierre Perreau, P. Brun, Olivier Weber, Konstantin Bourdelle, Thierry Poiroux, Bich-Yen Nguyen, J. Ducote, Claire Fenouillet-Beranger, Remi Beneyton, R. Bianchini, B. Orlando, Francois Andrieu, A. Margain, L. Tosti, F. Abbate, C. Borowiak, C. Richard, D. Pellissier-Tanon, O. Faynot, C. Richier, T. Benoist, Magali Gregoire, Pascal Gouraud, Frederic Boeuf, Thomas Skotnicki, J. Bustos, Sebastien Haendler, E. Gourvest, Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation (IMEP-LAHC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), STMicroelectronics [Crolles] (ST-CROLLES), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Unité Commune d'Expérimentation Animale, Institut National de la Recherche Agronomique (INRA), Silicon-on-Insulator Technologies (SOITEC), Parc Technologique des Fontaines, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National Polytechnique de Grenoble (INPG)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Université Grenoble Alpes (UGA)
Subjects: Power management, Engineering, Materials science, Silicon on insulator, 02 engineering and technology, 01 natural sciences, law.invention, law, 0103 physical sciences, Materials Chemistry, Electrical and Electronic Engineering, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, Metal gate, ComputingMilieux_MISCELLANEOUS, Ground plane, High-κ dielectric, 010302 applied physics, business.industry, Transistor, Electrical engineering, Biasing, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Threshold voltage, Modulation, Logic gate, Optoelectronics, 0210 nano-technology, business
Abstract: In this paper, we study how to boost the performance of FDSOI (Fully-Depleted Silicon On Insulator) devices with High-K and Single Metal gate by using the combination of Ultra-Thin Buried Oxide (UTBOX), Ground Plane (GP) and local back biasing integrated with our hybrid process. The interest of local back biasing is highlighted in term of threshold voltage VT modulation and power management study on the 45 nm 0.374 μm2 bitcells and on the ESD functionality as compared to bulk technology.
Published: 2013

23. In-field in-design metrology target integration for advanced CD and overlay process control via Dosemapper and high order overlay correction for 28nm and beyond logic node

Author: B. Le-Gratiet, Lionel Thevenon, E. Batail, D. Gueze, F. Bernard-Granger, F. Gardet, R. Bouyssou, M. P. Baron, Thierry Devoivre, R. Bianchini, Jean-Claude Marin, J. Ducote, and C. Pouly
Subjects: business.industry, Computer science, Process (computing), Process control, Node (circuits), Nanotechnology, Overlay, business, Computer hardware, Field (computer science), Metrology, Design for manufacturability
Abstract: Current process tool performances are getting significantly enhanced by the adoption of advanced process correction application such as DoseMapper for CD or high order overlay correction for overlay. These process control capabilities need appropriate sampling to be efficient. Usually for in field metrology sampling we used to operate with metrology targets placed inside the scribe lines, however in this case the larger the chip the less scribe lines we have and the less relevant is the intrafield sampling. As ST is an IDM we have the opportunity to share with our design division this process control problematic. Since 45/40nm node we have started to put in place the so-called EMET (Embedded Metrology Target) strategy which consists in in-design metrology targets placement. Initially these targets were placed using tiling tools but it soon appeared to be not efficient and even impossible when we talk about targets involving complex metal stack. This papers talks about our current embedded metrology target strategy which has been adapted to enable appropriate target placement for CD and overlay for all critical layers from active to via/metal’s. Solutions needed to be put in place to (i) keep the circuit safe by using Design Rule clean metrology targets, (ii) be highly visible by the designers by placing targets at chip floor planning definition (iii) be upgradable by enabling target re-designs without impact on chip design version.
Published: 2013

24. Grey hair: clinical investigation into changes in hair fibres with loss of pigmentation in a photoprotected population

Author: P D, Kaplan, T, Polefka, G, Grove, S, Daly, L, Jumbelic, D, Harper, M, Nori, T, Evans, R, Ramaprasad, and R, Bianchini
Subjects: Male, Pigmentation, Surface Properties, Photoelectron Spectroscopy, Age Factors, Middle Aged, Water Loss, Insensible, Elastic Modulus, Sunlight, Humans, Female, Hair Color, Shear Strength, Aged, Hair
Abstract: Loss of pigmentation in hair fibres is one of the most obvious phenotypic changes with ageing and has been a topic of increasing interest in the study of follicle biology. The onset of greying brings cosmetic complaints that grey fibres are wild or difficult to manage. Of course, these perceptions may be the consequence of visual obviousness rather than underlying physical or chemical differences. Although several studies have compared pigmented and unpigmented fibres, few have tried to control genetic and ethnic difference as well as extrinsic factors such as photoexposure and chemical treatment. We have recruited subjects with salt-and-pepper hair from a population of Old Order Mennonites who, for cultural reasons, are not only prohibited from chemically treating their hair but also limit their exposure to sunlight. Hair samples were examined for elemental composition, surface energy, Young's modulus, break stress, bending modulus, shear modulus and water sorption/desorption isotherm. The parameters were evaluated statistically for global differences, individual differences and typical individual differences. Consistent with previous published literature, few global differences were found between pigmented and unpigmented hair across the population. We do find that many individual subjects had differences between pigmented and unpigmented fibres. These differences tend to be more pronounced in bulk than in surface properties. The small differences in mechanical properties and moisture uptake and loss lend support to the perception by consumers that grey hair is wilder, drier and less manageable.
Published: 2011

25. Pharmacokinetics of acipimox and of its N-deoxy metabolite following single and repeated oral administration of a sustained release formulation to healthy volunteers

Author: C. Advenier, F. Ruff, C. Efthymiopoulos, D. M. F. Edwards, R. Bianchini, M. Strolin-Benedetti, and L. Musatti
Subjects: Acipimox, business.industry, Metabolite, Lipid-lowering agent, Pharmaceutical Science, Pharmacology, Dosage form, chemistry.chemical_compound, chemistry, Pharmacokinetics, Oral administration, medicine, Steady state (chemistry), Dosing, business, medicine.drug
Abstract: Acipimox is a lipid lowering agent currently used for the treatment of hyperlipoproteinemia at a dose of 250 mg thrice daily. A sustained release (SR) formulation, containing 500 mg acipimox, has been developed with the aim of reducing the number of daily doses. We report here the pharmacokinetics of acipimox and its N -deoxy metabolite following single and repeated administrations of this new formulation to ten healthy volunteers. Three treatments - single-dose, once-daily administration for 1 week, and twice-daily for a second week - were evaluated over a continuous administration period, and plasma levels were monitored by HPLC following the last dose of each treatment. The pharmacokinetics of acipimox were found to be similar after single and repeated administration of the SR formulation. All three treatments gave maximum plasma levels (mean C max range 4.2–5.1 μg/ml) comparable to the currently used treatment, but with retarded maxima (mean t max 5–6 h). A limited accumulation was detectable following twice-daily administration (mean R A approx. 1.25), and some minor alterations in this plasma profile probably reflected diurnal variations in pharmacokinetic parameters. This regimen maintained, over the 12 h dosing interval, average and minimum steady state concentrations which compare favourably with 8 h dosing of the standard formulation. Plasma levels of the metabolite increased noticeably with repeated dosing and plasma profiles were more variable than for acipimox. However, maximum concentrations (mean C max 0.5–0.8 μg/ml; mean t max 5–11 h) remained consistently lower than unchanged drug, and average steady state concentrations over a dosing interval were about 5-fold lower.
Published: 1993

26. d-Indobufen Extended-Release Pellets Prepared by Coating with Aqueous Polymer Dispersions

Author: R. Bianchini, Giovanna Bruni, Andrea Gazzaniga, and C. Vecchio
Subjects: Pharmacology, chemistry.chemical_classification, Indobufen, Aqueous solution, Materials science, Carboxylic acid, Organic Chemistry, Pellets, Pharmaceutical Science, Polymer, engineering.material, Dosage form, Chemical engineering, Coating, chemistry, Drug Discovery, medicine, engineering, Copolymer, medicine.drug
Abstract: A multiple units dosage form has been prepared in order to control the release of d-Indobufen, a carboxylic acid used as an inhibitor of platelet aggregation.The system consists of cores containing the active substance coated with a diffusive film and represents a classic “reservoir” system.Extrusion-spheronization was used in order to prepare the active cores. The drug release control was obtained by modifying both the core composition and the film composition characteristics.Acid and basic compounds were incorporated in the core to influence the inside microenvironment pH. Polymers chosen for the film formulation were: ethylcellulose (Aquacoat) and copolymers of acrylic esters with differing permeability characteristics (Eudragit RL/RS 30D).Technological and physical characteristics of coated pellets proved the production feasibility of an extended release multiple unit dosage form of d-Indobufen.Preliminary data of accelerated stability indicated the important role played by the thermal treatme...
Published: 1993

27. ChemInform Abstract: Efficient Synthesis of ω-Functionalized Nonanoic Acids

Author: S. Sguassero, P. Maggioni, Pietro Delogu, R. Bianchini, Livius Cotarca, and Alfonso Nardelli
Subjects: Chemistry, General Medicine, Combinatorial chemistry
Published: 2010

28. Influence of extrusion-spheronization processing on the physical properties of d-Indobufen pellets containing pH adjusters

Author: Andrea Gazzaniga, C. Vecchio, Giovanna Bruni, and R. Bianchini
Subjects: Pharmacology, Aqueous solution, Stereochemistry, Chemistry, Organic Chemistry, Pellets, Pharmaceutical Science, Dosage form, Agitator, Chemical engineering, visual_art, Drug Discovery, Pellet, visual_art.visual_art_medium, Extrusion, Dissolution testing, Acrylic resin
Abstract: d-Indobufen pellets containing pH adjusters (acids, buffer, salt) were prepared by extrusion-spheronization technology.The interaction effect between some processing variables (feeding/agitator speeds of extruder, plate speed and residence time of spheronizer) was evaluated by comparing the basic formulation pellets with the pellets in which the soluble filler (lactose) was substituted by fumaric, tartaric and citric acids and also sodium citrate.The criteria of formulation and process evaluation were the reproducibility of the particle size distribution, the density, the hardness and morphological properties, in addition to the reproducibility of the drug dissolution rates.In all cases, the physical/technological characteristics were not influenced very much by pH adjuster incorporation, but the drug dissolution profiles showed some significant variations in the first hour. As a logical extension of this work, wet granulations with aqueous ethylcellulose and acrylic resin dispersions instead of o...
Published: 1992

29. Managing annealing pattern effects in 45nm low power CMOS technology

Author: C. Chaton, Emmanuel Josse, R. Ranica, Emmanuelle Serret, Alexandre Villaret, Kathy Barla, A. Colin, M. Bidaud, H. Bono, Thierry Devoivre, Florian Cacho, B. Dumont, Michel Haond, R. Binger, C. Gallon, Remi Beneyton, Pierre Morin, and R. Bianchini
Subjects: Materials science, CMOS, law, Low-power electronics, MOSFET, Dispersion (optics), Electronic engineering, Electronic packaging, Wafer, Laser, Temperature measurement, law.invention
Abstract: We present a study of the pattern effects induced by spike and laser anneals in LP 45nm CMOS platform. A complete optical and thermal simulation methodology that provides the intra-field temperature mapping has been developed and validated by electrical measurement. This work enables significant improvements, by decreasing the optical dispersion, through an optimized dummification at long and short scale, possibly the use of an absorbent layer, and by reducing the temperature device sensitivity.
Published: 2009

30. Technological Evaluation of Aqueous Enteric Coating Systems with and Without insoluble Additives

Author: M. Resciniti, C. Vecchio, and R. Bianchini
Subjects: Pharmacology, chemistry.chemical_classification, Aqueous solution, Stereochemistry, Organic Chemistry, Pharmaceutical Science, chemistry.chemical_element, Polymer, Talc, Enteric coating, chemistry.chemical_compound, chemistry, Chemical engineering, Cellulose acetate phthalate, Drug Discovery, medicine, Copolymer, Dissolution, Titanium, medicine.drug
Abstract: The most recent dispersible enteric polymers such as AQUATERIC, HPMCP HP 55 F, EUDRAGIT L 100 55 and cellulose acetate phthalate (micronized in our laboratory), were evaluated on two different physical and chemical substrates (soluble and insoluble). Four standard formulations were used with and without the most common solid additives such as talc and titanium dioxide.A good distribution of all coatings was obtained on the both substrates previously studied.The mechanical properties and the dissolution profile of gastric resistance showed clearly that the methacrylic copolymer-based product is a good alternative to esther celluloses manufactured with the most modern technologies.
Published: 1991

31. Dynamically Quantifying and Improving the Reliability of Distributed Storage Systems

Author: C. Dubnicki, Rekha Bachwani, L. Gryz, and R. Bianchini
Subjects: Distributed database, Computer science, business.industry, Data reconstruction, Distributed computing, System recovery, Distributed data store, Computer data storage, Redundancy (engineering), Erasure code, business, Scheduling (computing), Reliability engineering
Abstract: In this paper, we argue that the reliability of large-scale storage systems can be significantly improved by using better reliability metrics and more efficient policies for recovering from hardware failures. Specifically, we make three main contributions. First, we introduce NDS (Normalcy Deviation Score), a new metric for dynamically quantifying the reliability status of a storage system. Second, we propose MinI (Minimum Intersection), a novel recovery scheduling policy that improves reliability by efficiently reconstructing data after a hardware failure. MinI uses NDS to tradeoff reliability and performance in making its scheduling decisions. Third, we evaluate NDS and MinI for three common data-allocation schemes and a number of different parameters. Our evaluation focuses on a distributed storage system based on erasure codes. We find that MinI improves reliability significantly, as compared to conventional policies.
Published: 2008

32. Accreditation experience of radioisotope metrology laboratory of Argentina

Author: M. Carballido, A. Iglicki, X. Araya, G. Cerutti, J.C. Furnari, R. Bianchini, M.I. Milá, V. Guillén, and P. Arenillas
Subjects: Engineering, Radiation, Quality Assurance, Health Care, business.industry, Argentina, Radiation Dosage, Atomic energy commission, Metrology, Accreditation, Quality management system, Radiation Protection, Radiation Monitoring, Systems engineering, Calibration, Nuclear Medicine, Radiopharmaceuticals, Quality policy, business, Laboratories, Quality assurance
Abstract: This work presents the experience developed by the Radioisotope Metrology Laboratory (LMR), of the Argentine National Atomic Energy Commission (CNEA), as result of the accreditation process of the Quality System by ISO 17025 Standard. Considering the LMR as a calibration laboratory, services of secondary activity determinations and calibration of activimeters used in Nuclear Medicine were accredited. A peer review of the ( α / β ) - γ coincidence system was also carried out. This work shows in detail the structure of the quality system, the results of the accrediting audit and gives the number of non-conformities detected and of observations made which have all been resolved.
Published: 2006

33. Left ventricle remodeling after aortic valve replacement with a stentless bioprosthesis

Author: C, Valfrè, P, Ius, C, Zussa, F, Rigo, R, Bianchini, E, Polesel, and R J, Zennaro
Subjects: Bioprosthesis, Ventricular Remodeling, Aortic Valve, Heart Valve Prosthesis, Heart Valve Diseases, Humans, Hypertrophy, Left Ventricular, Prosthesis Design
Published: 2004

34. [Sport activity in children and adolescents: temperament and emotional traits]

Author: L, Mazzone, D, Mugno, G, Morales, V, Genitori D'Arrigo, L, Ruta, and R, Bianchini
Subjects: Male, Affect, Adolescent, Social Desirability, Surveys and Questionnaires, Humans, Female, Anxiety, Child, Temperament, Severity of Illness Index, Settore MED/39 - Neuropsichiatria Infantile, Sports
Abstract: Aim of this study is to evaluate anxiety and temperament characteristics in developmental age subjects who practised agonistic sport (individual or team sports) in comparison with a sample group of subjects who practice no agonistic sports.Sixty subjects aged from 10 to 16 years were enrolled in the study and divided into 3 groups: 20 subjects practised individual agonistic sport (Group A), 20 subjects practised team agonistic sports (Group B) and 20 subjects who practised non agonistic sport as control group, (Group C). The following tests were used: multidimensional anxiety scale for children (MASC) to evaluate anxiety, EAS scale (Buss e Plomin) to evaluate temperament (emotionability, activity, sociability and shyness for younger children).MASC scale scores underline generalized anxiety with higher significantly score in subjects who practised agonistic sports (Group A and B) compared with Group C. Anxiety symptoms were more evident in subjects who practised individual discipline compared with those who practised team sports. EAS scale indicated that temperament of subjects who practised agonistic sport was characterised by a considerable aptitude for sociability with low emotionability/activity levels in comparison to control group.None of the 3 groups showed a psychopathologic profile.
Published: 2004

35. Application transformations for energy and performance-aware device management

Author: T. Heath, E. Pinheiro, J. Hom, U. Kremer, and R. Bianchini
Published: 2003

36. Disk write caching with an optical network

Author: E.V. Carrera and R. Bianchini
Subjects: Ring (mathematics), Hardware_MEMORYSTRUCTURES, Parallel processing (DSP implementation), Computer science, Scalability, Multiprocessing, Page cache, Cache, Parallel computing, Optical storage, Electrical capacitance tomography
Abstract: In this paper we propose a simple extension to the optical network of a scalable multiprocessor that optimizes page swap-outs significantly. More specifically, we propose to extend the network with an optical ring that not only transfers swapped-out pages between the local memories and the disks of the multiprocessor but also acts as a system-wide write cache for these pages. This extended optical network has several performance benefits: it provides a staging area where swapped-out pages can reside until the disk is free; it increases the possibility of combining several writes to disk; and it acts as a victim cache for pages that are swapped out and subsequently accessed by the same or a different processor. In order to evaluate the extent to which these benefits affect performance, we use detailed execution-driven simulations of several out-of-core parallel applications running on an 8-node scalable multiprocessor. Our results demonstrate that our optical ring provides consistent performance improvements, coming mostly from faster page swap-outs and victim caching. Based on these results and on our parameter space study, our main conclusion is that our optical ring is highly efficient under several architectural assumptions and for most out-of-core parallel applications.
Published: 2003

37. A compact design for a highly-parallel shared-memory MIMD computer

Author: Patricia J. Teller, Susan R. Dickey, R. Bianchini, and Richard Kenner
Subjects: MIMD, Hardware_MEMORYSTRUCTURES, Shared memory, Computer architecture, Computer science, Interleaved memory, Cache-only memory architecture, Uniform memory access, Registered memory, Distributed memory, Parallel computing, ComputerSystemsOrganization_PROCESSORARCHITECTURES, CAS latency
Abstract: The ultracomputer architecture connects hundreds or possibly thousands of processing elements (PEs), each containing a cache but no local memory, to an equal number of memory modules (MMs) via an interconnection network constructed of custom VLSI components that combine (merge) requests from different PEs destined to the same memory location. The network provides a high-bandwidth path from the PEs to MMs, but the memory latency is significantly larger than that encountered in either a uniprocessor or small bus-based multiprocessor. The PE must utilize the high available bandwidth and minimize the effect of network latency. The authors present a design of a 64-PE ultracomputer prototype using AMD AM29000 CPUs, including a description of system packaging using a backplane-free technology. The prototype is expected to be operational in 1990. >
Published: 2003

38. Simulation of the Adapt on-line diagnosis algorithm for general topology networks

Author: M. Stahl, R. Buskens, and R. Bianchini
Subjects: Computer science, Distributed computing, Algorithm design, General topology, Latency (engineering), Network topology, Algorithm
Abstract: As dependence on wide-area and other point-to-point networks increases, the need for diagnosis of the distributed resources becomes critical. Continuous online distributed diagnosis at the system-level provides a desirable solution. The Adapt algorithm, which performs online adaptive distributed diagnosis in arbitrary networks in the presence of node failures, is examined. Simulation results depicting operation for various network topologies are given, including test and message counts and diagnosis latency. The results indicate that Adapt performs significantly better than derived worst-case bounds. The best- and worst-case performance bounds are analyzed. >
Published: 2003

39. Software caching on cache-coherent multiprocessors

Author: R. Bianchini and Thomas J. LeBlanc
Subjects: Hardware_MEMORYSTRUCTURES, Software caching, Computer architecture, Computer science, Inline caching, False sharing, Software performance testing, Cache, Application software, computer.software_genre, Data structure, computer, Variety (cybernetics)
Abstract: The authors explore the utility of software caching on a machine with coherent caches. In particular, they show that by caching at the application level one can avoid the problem of false sharing on cache-coherent machines. They compare the performance of software caching with that of other techniques for alleviating false sharing and show that software caching performs better than the alternatives when the reference behavior of an application changes dynamically. It is concluded that software caching, as well as other techniques developed for noncoherent shared-memory multiprocessors, can be profitably used on machines with hardware coherent caches and that programs based on these techniques are efficient across a variety of shared-memory machines. >
Published: 2003

40. The Adapt2 on-line diagnosis algorithm for general topology networks

Author: R. Buskens, R. Bianchini, and M. Stahl
Subjects: Computer science, Node (networking), Distributed computing, Key (cryptography), Overhead (computing), Algorithm design, General topology, Network topology, Algorithm, Fault detection and isolation
Abstract: As dependence on wide area and other point-to-point networks increases, the need for diagnosis of the distributed resources becomes critical. Continuous online distributed diagnosis at the system-level provides a desirable solution. The Adapt2 algorithm, which performs online adaptive distributed diagnosis in arbitrary networks in the presence of node and link failures, is described. The algorithm is shown to have better execution bounds and lower overhead than previous methods. Key results include worst-case performance bounds. >
Published: 2003

41. Using communication-to-computation ratio in parallel program design and performance prediction

Author: Thomas J. LeBlanc, Mark Crovella, R. Bianchini, R. Wisniewski, and Evangelos P. Markatos
Subjects: Computer engineering, Computer science, Computation, Code (cryptography), Process (computing), Performance prediction, Program Design Language, Parallel computing, Application software, computer.software_genre, computer
Abstract: The authors goal is to be able to predict the performance of a parallel program early in the program development process; to that end they require prediction methods that can be based on incomplete programs. They describe how a single method based on communication-to-computation (C/C) ratio can be used to predict performance accurately and yet fairly simply in some commonly encountered cases. They show how C/C-ratio-based methods are accomplished for both distributed-memory and coherent-memory multiprocessors. They show that focusing on C/C ratio simplifies the use of theory, machine benchmarking and application measurement necessary to provide good parallel performance prediction. In addition, the methods demonstrated are useful because they can be applied to program fragments, or serially executed code. >
Published: 2003

42. Minimum thickness of concrete pavement for the F-15 and C-17 aircraft

Author: Gonzalez, Carlos R.; Barker, Walter R.; Bianchini, Alessandra, United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Geotechnical and Structures Laboratory (U.S.), Gonzalez, Carlos R.; Barker, Walter R.; Bianchini, Alessandra, and United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Geotechnical and Structures Laboratory (U.S.)
Abstract: ERDC/GSL TR-13-34 Minimum Thickness of Concrete Pavement for the F-15 and C-17 Aircraft Geotechnical and Structures Laboratory Carlos R. Gonzalez, Walter R. Barker, and Alessandra Bianchini July 2013 Approved for public release; distribution is unlimited. The US Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges. ERDC develops innovative solutions in civil and military engineering, geospatial sciences, water resources, and environmental sciences for the Army, the Department of Defense, civilian agencies, and our nation’s public good. Find out more at www.erdc.usace.army.mil. To search for other technical reports published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/client/default. ERDC/GSL TR-13-34 July 2013 Minimum Thickness of Concrete Pavement for the F-15 and C-17 Aircraft Carlos R. Gonzalez, Walter R. Barker, and Alessandra Bianchini Geotechnical and Structures Laboratory US Army Engineer Research and Development Center 3909 Halls Ferry Road Vicksburg, MS 39180-6199 Final report Approved for public release; distribution is unlimited. Prepared for US Army Corps of Engineers Washington, DC 20314-1000 ERDC/GSL TR-13-34 ii Abstract The procedure for the design of military rigid airfield pavements contained in the Unified Facilities Criteria 3-260-02 gives the minimum thickness of airfield concrete pavements as 6 in. The introduction of the C-17 aircraft and the requirement that dowel bars be used as load transfer mechanisms at joints for airfield pavements bring into question the validity of the 6 in. minimum thickness. With the objective of updating such minimum thickness criteria, a full-scale test section was constructed and trafficked with wheel loads simulating F-15, B-52, and C-17 aircraft traffic. Test section performance was evaluated by recording the number of passes to failure and by utilizing the falling weight deflectometer testing to measure the stiffness an
Published: 2013

43. Eager combining: a coherency protocol for increasing effective network and memory bandwidth in shared-memory multiprocessors

Author: R. Bianchini and Thomas J. LeBlanc
Subjects: Shared memory, Computer science, Distributed computing, Bandwidth (computing), Time-sharing, Multiprocessing, Memory bandwidth, Data structure, Protocol (object-oriented programming)
Abstract: An excessive number of remote accesses or a non-uniform distribution of remote accesses can cause even well-designed multiprocessors to exhibit severe memory and network contention. Producer/consumer data generates a particularly common sharing pattern that results in a non-uniform distribution of references. In this paper we quantify the performance impact of producer/consumer sharing as a function of memory and network bandwidth, and argue that the contention caused by this form of sharing severely impacts performance on large-scale machines. We propose a new coherency protocol, called eager combining, which is designed to alleviate this contention. We use execution-driven simulation of parallel programs on a large-scale multiprocessor to show that eager combining can improve the performance of programs with producer/consumer data by a factor of 4 or more. >
Published: 2002

44. Practical application and implementation of distributed system-level diagnosis theory

Author: K. Goodwin, Daniel S. Nydick, and R. Bianchini
Subjects: Workstation, Computer science, Distributed computing, Local area network, System testing, Control reconfiguration, Application software, computer.software_genre, Telecommunications network, law.invention, Resource (project management), Distributed algorithm, law, computer
Abstract: A DSD (distributed self-diagnosing) project that consists of the implementation of a distributed self-diagnosis algorithm and its application to distributed computer networks is presented. The EVENT-SELF algorithm presented combines the rigor associated with theoretical results with the resource limitations associated with actual systems. Resource limitations identified in real systems include available message capacity for the communication network and limited processor execution speed. The EVENT-SELF algorithm differs from previously published algorithms by adopting an event-driven approach to self-diagnosability. Algorithm messages are reduced to those messages required to indicate changes in system those messages required to indicate changes in system state. Practical issues regarding the CMU-ECE DSD implementation are considered. These issues include the reconfiguration of the testing subnetwork for environments in which processors can be added and removed. One of the goals of this work is to utilize the developed CMU-ECE DSD system as an experimental test-bed environment for distributed applications. >
Published: 2002

45. Algorithms for categorizing multiprocessor communication under invalidate and update-based coherence protocols

Author: Leonidas Kontothanassis and R. Bianchini
Subjects: Data traffic, Hardware_MEMORYSTRUCTURES, Computer science, Transaction processing, Distributed computing, Multiprocessing, computer.software_genre, Categorization, Virtual machine, Coherence (signal processing), Cache, Algorithm, computer, Cache coherence
Abstract: Presents simulation algorithms that characterize the main sources of communication generated by parallel applications under both invalidate and update-based cache coherence protocols. The algorithms provide insight into the reference and sharing patterns of parallel programs and into the amount of useless traffic entailed by each coherence protocol. Under an invalidate-based protocol, our algorithms classify the data traffic caused by the different types of cache misses. Under an update-based protocol, our algorithms not only categorize the data traffic, but also classify update transactions with respect to the sharing patterns that caused them. Although our algorithms deal with numerous hardware features, our categorization is widely applicable and can be easily simplified for use in less detailed simulators. >
Published: 2002

46. Employing high resolution satellite images to update urban maps at medium-large scale and its impact on developing countries

Author: V. Baiocchi, M. Crespi, R. Bianchini, and F. Maimone
Subjects: Metadata, geography, geography.geographical_feature_category, Level of measurement, Orthophoto, Satellite, Urban area, Representation (mathematics), Scale (map), Image resolution, Cartography, Remote sensing
Abstract: The availability of commercial high resolution satellite images has drawn cartographer's attention to utilise them for urban area mapping. Orthorectified images may be used as a map directly or as a support to update existing maps at medium-large scale. Nevertheless, the nominal resolution itself does not guarantee that images are suitable for this specific use: the acquisition geometry and the actual resolution may limit the applicability of this product. In fact, the nominal scale, certified in the ancillary metadata files, does not reflect the actual geometric scale of the image automatically. Furthermore, off-nadir angle and sun elevation angle influence the geometry of the image and the object representation. This has significant effects particularly in urban areas, where urban features and their shadows may mask wide areas. However, the availability of these images may be of crucial importance in developing countries, where maps are lacking or it is difficult to obtain them. In this study an application of Ikonos images to the city of Tangier (Morocco) is developed. The usage of images, the comparison between the orthorectified image and the existing maps of the city and the process of drawing the map are addressed and discussed.
Published: 2001

47. Reformulation of the CBR procedure

Author: Gonzalez, Carlos R.; Barker, Walter R.; Bianchini, Alessandra, United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Geotechnical and Structures Laboratory (U.S.), Gonzalez, Carlos R.; Barker, Walter R.; Bianchini, Alessandra, and United States. Army. Corps of Engineers; Engineer Research and Development Center (U.S.); Geotechnical and Structures Laboratory (U.S.)
Published: 2012

48. Projetando e Avaliando Sistemas Baseados em Entry Consistency e Lock Acquirer Prediction

Author: Cristiana B. Seidel, R. Bianchini, and Claudio L. Amorim
Abstract: Esse trabalho apresenta os resultados da implementação real dos sistemas software DSM AEC e AEC-light, desenvolvidos a partir da técnica LAP, que prevê dinamicamente a ordem de transferência dos locks numa aplicação paralela. Ambos os sistemas são baseados no modelo de consistência Entry Consistency, mas utilizam modelos de programação distintos. AEC utiliza modelo de programação com associação implícita de dado compartilhado com variável de sincronização, enquanto que o modelo utilizado por AEC-light requer que essa associação seja feita de forma explícita. De forma a avaliar os sistemas, realizamos experimentos com um conjunto representativo de aplicações executando no sistema SP-2 com 8 nós de processamento. Nossos resultados mostram que o uso de protocolo de atualização aliado à técnica LAP em AEC permite reduções de até 48% no tempo de execução em relação ao sistema TreadMarks. Nossos resultados demonstram ainda que, através do uso de modelo de programação mais elaborado, AEC-light pode alcançar desempenho até 17% superior ao do sistema AEC. Entretanto, observamos que, quando a aplicação apresenta granularidade fina de acesso ao(s) dado(s) protegido(s) por cada lock, AEC e AEC-light apresentam desempenho inferior a TreadMarks. Baseados nesses resultados preliminares, concluímos que AEC e AEC-light podem alcançar bom desempenho, mas ainda precisam ser ajustados para tratar acessos a dados com granularidade fina.
Published: 1998

49. A Segunda Geração de Computadores de Alto Desempenho da COPPE/UFRJ

Author: C. L. Amorim, R. Bianchini, G. Silva, R. Pinto, M. Hor-Meyll, M. De Maria, L. Whately, and J. Assunção Jr.
Abstract: Sistemas de memória compartilhada distribuída (DSMs) podem ser implementados completamente em software. Esses sistemas, conhecidos como software DSMs, exibem um baixo custo e, portanto, representam uma alternativa atraente para computação paralela. Entretanto, software DSMs puros atingem alto desempenho numa classe restrita de aplicações. O sistema paralelo NCP2 introduz a segunda geração de computadores de alto desempenho da COPPE/UFRJ, a qual investiga a utilização de hardware simples e de baixo custo para otimizar software DSMs. Esse hardware consiste de controladores de protocolo programáveis que permitem a implementação de técnicas de tolerância à latência de comunicação e a overheads de processamento de coerência. Nossas simulações revelam que os nossos controladores de protocolo melhoram o desempenho de TreadMarks em 16 processadores em até 52%. Esses resultados sugerem que o NCP2 exibirá uma ótima relação custo/desempenho numa grande gama de aplicações, proporcionando uma opção tecnológica muito boa para investimentos nacionais em computação de alto desempenho.
Published: 1996

50. [Quality of life in patients undergoing mitral valve substitution]

Author: G, Speziale, O, Spadaro, R, Bianchini, M S, Jozdani, A, Speziale, G, Ruvolo, and B, Marino
Subjects: Male, Mitral Valve Insufficiency, Middle Aged, Prognosis, Treatment Outcome, Italy, Patient Satisfaction, Heart Valve Prosthesis, Surveys and Questionnaires, Quality of Life, Humans, Mitral Valve Stenosis, Female, Aged
Abstract: The aim of the present study was to evaluate the quality of life after mitral valve replacement through the analysis of behavioural, psychological, functional, economic and working changes, as well as alterations in social and sexual life after surgery.The study was performed before and after surgery in a cardiological ward.The population studied included 206 patients undergoing mitral valve replacement surgery. Results were compared with a control population of patients suffering from mitral valve disease and receiving medical therapy.All patients were asked by medical staff to compile a series of five self-evaluation questionnaires: General Well-Being Schedule, Physical Symptoms Distress Index B, Social Participation, Sexual Satisfaction Unified Test and Work Performance and Satisfaction.Our results showed a significant improvement in the perception of quality of life after mitral valve replacement. In particular, the state of general well-being improved significantly with a clear reduction in symptoms. This was accompanied by a reduction in sexual activity and no change in social life or working capacity. Data obtained in the group of patients operated showed a significant improvement in the perception of the quality of life and psycho-physical well-being compared to patients receiving medical treatment alone.From this study it can be seen that patients undergoing mitral valve replacement surgery experience a marked improvement in the quality of life compared to pre-operative conditions and to the group of patients receiving medical therapy for mitral valve diseases. The use of specific working and social rehabilitation programmes can certainly optimise the results also with regard to affective relations.
Published: 1995

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