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43 results on '"R. A. Dierckx"'

1. EDITORIAL

Author

C Van de Wiele, S Rottey, I Goethals, J Buscombe, S Van Belle, F De Vos, and R A Dierckx

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine
Published
2003
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2. Is there a role for agonist gastrin-releasing peptide receptor radioligands in tumour imaging?

Author

Guido Slegers, Susan H. Peers, S. Van Belle, R A Dierckx, C. Van de Wiele, and Filip Dumont

Subjects
Agonist, medicine.medical_specialty, medicine.drug_class, Cell, digestive system, chemistry.chemical_compound, Prostate, Neoplasms, Internal medicine, Gastrin-releasing peptide, medicine, Gastrin-releasing peptide receptor, Humans, Radiology, Nuclear Medicine and imaging, Radionuclide Imaging, Receptor, business.industry, Bombesin, General Medicine, Ligand (biochemistry), Receptors, Bombesin, medicine.anatomical_structure, Endocrinology, Gastrin-Releasing Peptide, chemistry, Cancer research, Radiopharmaceuticals, business, hormones, hormone substitutes, and hormone antagonists
Abstract

Gastrin-releasing peptide (GRP) has been shown to be a tumour growth stimulating agent for a number of normal and human cancer cell lines. The tumour growth effect is a direct result of GRP binding to membrane G-protein coupled GRP receptors (GRP-R) on the cell surface. Available data on the role of GRP and GRP-R in human lung, prostate, breast, colorectal and gastric carcinoma are reviewed and it is suggested that radiolabelled agonists are preferable to antagonists for imaging and therapy as they appear to be internalised, yielding a higher target/background ratio. The use of rhenium or indium radiolabels for therapy may provide a new approach to GRP/bombesin expressing tumours.

Published
2001
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4. 57Co-EDTA renal imaging in rats

Author

F De Winter, C. Van de Wiele, A Volkaert, R A Dierckx, Patrick Goethals, and Hubert Thierens

Subjects
Male, medicine.medical_specialty, Biodistribution, Urinary system, Renal function, Urine, Kidney, High-performance liquid chromatography, Pharmacokinetics, Internal medicine, medicine, Animals, Tissue Distribution, Radiology, Nuclear Medicine and imaging, Chelation, Cobalt Radioisotopes, Rats, Wistar, Radionuclide Imaging, Edetic Acid, Chromatography, Chemistry, General Medicine, Rats, Endocrinology, medicine.anatomical_structure, Glomerular Filtration Rate
Abstract

We studied the synthesis of 57Co-EDTA (Ey = 122 keV), its biodistribution in Wistar rats and its blood and urinary elimination compared with that of 51Cr-EDTA. We added 6 mumol EDTA diluted in 3-5 ml isotonic phosphate buffer (Na2HPO4) to a commercial 57CoCl2 radioactive tracer solution. The incubation period was 15 min. Quality control was performed using TLC and HPLC. Six healthy Wistar rats underwent 57Co-EDTA renography for 30 min. In one rat, additional TLC and HPLC was performed on blood (one sample only) and urine samples (n = 3) obtained 30 min, 30 min, 2 h and 4 h following injection of 18.5 MBq 57Co-EDTA and 51Cr-EDTA respectively. Radioisotope quantification was done by means of a germanium detector. 57Co was chelated to EDTA at high yield (Kstab = 10E36). No free or protein-bound 57Co was found. The ratio of 51Cr-EDTA to 57Co-EDTA remained constant (P = 0.133, n = 4). 57Co-EDTA was rapidly cleared from the blood pool (heart), and prompt and high target-to-background ratios for both kidneys were obtained (mean = 8.4, range = 7-12). At the end of the acquisition, activity remaining in the body excluding kidney and bladder was 45 +/- 5.2%. No specific activity uptake was noted in any other organ or tissue. We conclude that 57Co-EDTA is a promising radioligand for simultaneous clearance and separate renal function estimation. Its preparation is straightforward and, in rats, no free or protein-bound 57Co was found.

Published
2000
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5. PACS and multimodality in medical imaging

Author

R. Van de Walle, K. Van Laere, Stefaan Vandenberghe, Yves D'Asseler, L. Bouwens, C. Van de Wiele, Ignace Lemahieu, R A Dierckx, and Michel Koole

Subjects
medicine.medical_specialty, Modality (human–computer interaction), Modalities, Similarity (geometry), business.industry, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Biomedical Engineering, Biophysics, Health Informatics, Bioengineering, computer.software_genre, Multimodality, Biomaterials, Picture archiving and communication system, Voxel, Medical imaging, Medicine, Computer vision, Medical physics, Artificial intelligence, Medical diagnosis, business, computer, Information Systems
Abstract

A PACS (Picture Archiving and Communication System) is a system that is able to store, exchange, display and manipulate images and associated diagnoses from any modality within a hospital in a timely and cost-effective way. Several developments, such as the DICOM standard, fast and convenient networking, and new storage solutions for large amounts of data, make the setup of such a PACS system possible. As the information acquired with various imaging modalities is then available and often complementary, it is desirable for the clinician to have a point-by-point spatial co-registration of images from different modalities in order to enable a synergistic use of the multimodality imaging of a patient for increased diagnostic accuracy. Various types of algorithms are available for the matching of medical images from the same or from different modalities. Co-registration algorithms based on voxel properties consist of a similarity or dissimilarity measure and an iterative or non-iterative method minimizing the dissimilarity or maximizing the similarity between the two images by a transformation of one image relative to the other.

Published
2000
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6. Estimation of risk based on biological dosimetry for patients treated with radioiodine

Author

L. de Ridder, I A Meirlaen, J. M. Kaufman, Hubert Thierens, R A Dierckx, Myriam Monsieurs, H A de Winter, C. Van de Wiele, Anne Vral, and C. De Sadeleer

Subjects
Adult, Male, medicine.medical_treatment, Binucleated cells, Thyroid Gland, chemistry.chemical_element, Iodine, Risk Assessment, Iodine Radioisotopes, Thyroid carcinoma, medicine, Humans, Radiology, Nuclear Medicine and imaging, Blood culture, Thyroid Neoplasms, External beam radiotherapy, Radiometry, Radionuclide Imaging, Aged, Aged, 80 and over, Micronucleus Tests, medicine.diagnostic_test, business.industry, Dose-Response Relationship, Radiation, General Medicine, Middle Aged, Radiation therapy, Red blood cell, Thyrotoxicosis, medicine.anatomical_structure, chemistry, Micronucleus test, Female, Nuclear medicine, business, Half-Life
Abstract

A multicentre study was undertaken to assess the cytogenetic damage to peripheral blood lymphocytes in 31 patients treated with 1.31 I for thyrotoxicosis using the cytokinesis-blocked micronucleus assay. The results were compared to those for eight thyroid carcinoma patients using the same method. For each patient, blood samples were taken immediately before and 1 week after iodine administration. The first blood sample was divided into three fractions and each fraction was subsequently irradiated in vitro with 0, 0.5 and 1 Gy 60 Co gamma rays, respectively. After blood culture for 70 h, cells were harvested, stained with Romanowsky-Giemsa and the micronuclei scored in 1000 binucleated cells. For both patient groups, a linear-quadratic dose-response curve was fitted through the data set of the first blood sample by a least squares analysis. The mean increase in micronuclei after 131 I therapy (second blood sample) was fitted to this curve and the mean equivalent total body dose (ETBD) calculated. Surprisingly, in view of the large difference in administered activity between thyroid carcinoma patients and thyrotoxicosis patients, the increase in micronuclei after therapy (mean ± S.D.: 32 ± 30 and 32 ± 23, respectively) and the equivalent total body dose (0.34 and 0.32 Gy, respectively) were not significantly different (P > 0.1). The small number of micronuclei induced by 131 I therapy (32 ± 29), compared with external beam radiotherapy for Hodgkin's disease (640 ± 381) or cervix carcinoma (298 ± 76) [1], gave a cancer mortality estimate of less than 1%. This also explains why late detrimental effects in patients after 131 I treatment have not been reported in the literature.

Published
1999
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7. [11C]choline PET for the intraprostatic tumor characterization and localization in recurrent prostate cancer after EBRT

Author

M, Rybalov, A J, Breeuwsma, J, Pruim, A M, Leliveld, S, Rosati, N C, Veltman, R A, Dierckx, and I J, De Jong

Subjects
Male, Prostatic Neoplasms, Reproducibility of Results, Middle Aged, Sensitivity and Specificity, Choline, Positron-Emission Tomography, Humans, Female, Carbon Radioisotopes, Neoplasm Recurrence, Local, Radiopharmaceuticals, Radiotherapy, Conformal, Aged
Abstract

This study focuses on the potential role of [11C]choline positron emission tomography (PET) for the intraprostatic tumor characterization and localization in recurrent prostate cancer after EBRT.This retrospective study was conducted in patients who were being followed up after EBRT for histological proven prostate cancer. We selected the patients with a local recurrence by [11C]choline PET/CT fusion. The results of PET were compared with the results of histology and with clinical follow-up.Forty-two patients with a local recurrence suggested by PET were included in this study. According to PET results: of the 42 patients, 15 (36%) had a focal recurrence, 27 (64%) showed a diffuse recurrence. The overall concordance of PET with histology concerning detection of recurrence was 76% (32 patients had positive PET results and positive biopsies). We confirmed the local recurrence as visualized by PET in 37/42 (88%) patients using a composite reference with histology and clinical follow up after local salvage treatment. The concordance of the intraprostatic distribution of the tumor with PET with histology from transrectal prostate biopsies (median biopsies 7, range 4-12) was 47% (7/15) in unilateral cases and 41% (11/27) in bilateral cases. No significant differences were seen between the 2 groups in serum PSA at time of PET (P=0.509) and SUV (P=0.739) using Student's t-test.Intraprostatic characterization of recurrent prostate cancer after EBRT with 11C-choline PET is feasible at present but shows a moderate concordance with routine transrectal prostate biopsies. The accuracy is too low for the routine use of this modality in the present scenario.

Published
2012

8. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author

H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. Lane, A. Hofman, M. Verin, T. Matilla, P. Bedoucha, J. Roche, M. Lai, M. Collard, A. Ugarte, F. Gallecho, D. Silbersweig, C. Kennard, J. P. Azulay, T. W. Ho, P. L. I. Dellemijn, R. Girardello, F. Baas, B. Voss, F. Rozenberg, E. M. Brocker, V. Stanev, A. A. J. Soeterboek, A. Marra, A. Rey, E. Ertem, M. Sawradewicz-Rybak, J. De Keyser, P. Cavallari, F. Proust, Y. Chevalier, H. C. Hansen, D. Leys, C. A. Davie, K. Hoang-Xuan, C. Bairati, H. van Crevel, Thomas T. Warner, B. Bompais, A. Dobbeleir, T Campbell, C. Macko, C. J. M. Klijn, M. Dussallant, T. P. Berlit, W. Rozenbaum, M. J. van den Bent, W. A. Rocca, M. Muller, H. Hundemer, U. Zifko, M. Campera, F. Drislane, D. Ranoux, T. M. Kloss, Anil Kumar, I. Ruolt, C. Bargnani, B. Marescau, N. A. Losseff, S. Notermans, B. Kint, E. T. Burke, C. Aykut, J. Matias Guiu, P. Maquet, T. Drogendijk, M. Leone, K. von Ammon, M. Pepeliarska, C. Prados, L. DiGiamberardino, T. Logtenberg, G. Lenoir, I. Castaldo, Damhaut, M. Radionova, G. Sirabian, R. Navon, Giovanni Antonini, K. Al Moutaery, E. Chamas, R. Schönhuber, M. Giannini, B. Debilly, I. Labatut, H. Henon, J. A. Egido, M. Baudrimont, J. N. Lorenzo, J. E. C. Bromberg, R. Antonacci, J. J. Vilchez, T. Moulin, B. Rautenstrauss, Giovanni Meola, J. Noth, S Mammi, P. Laforet, F. Lopez, C. Gehring, S. Bort, G. Rancurel, D. Decamps, S. Kostadinova, Y. Shapira, B. Neundoerfer, D. Chavrot, M. Solimena, J. P. Salier, W. Deberdt, R. Hoff-Jörgensen, A. Messina, S. Meairs, G. Rosoklija, E. Nelis, I. Bertran, C. Ertekin, J. Lohmeyer, Mitermayer Galvao dos Reis, L. Calo, E. Maccagnano, A. P. Hays, J. Verlooy, M. G. Forno, T. Blanco, L. Bail, Gabriella Silvestri, J. Montero, F. Bertrand, R. T. Ghnassia, C. Besses, T. Sereghy, F. Shalit, G. Bogliun, S. Braghi, St. Baykouchev, C. Franke, A. Lasa, L. C. Archard, J. Kriebel, S. Shaunak, M. Nocito, Alexander Tsiskaridze, E. Manfredini, T. Seigal, David G. Gadian, M. Barlas, J. D. Degos, C. Seeber, J. Caemert, J. L. Mas, R. B. Pepinsky, M. G. D'Angelo, N. Baumann, S. Yorifuji, H. P. Endtz, M. A. Cassatella, R. A. C. Hughes, V. Golzi, A. Bittencourt, A. Ferreira, M. Sanson, C. Alper, M. Vermeulen, M. A. A. van Walderveen, E. Alexiou, C. H. Lucas, M. Fiorelli, Y. N. Debbink, R. Gil, S. Congia, T. Banerjee, J. M. Bouchard, A. N. Pinto, A. Ceballos-Baumann, G. Grollier, P. I. M. Schmitz, M. D. Catata, N. Lahat, N. S. Rao, P. Papathanasopoulos, J. Valls-Solé, D. Claus, G. Schroter, A. Castro, C. Videbaek, R. Martinez Dreke, A. D. Platts, M. Hermesl, A. C. PeÇanha-Martins, M. Cardoso Silva, P. Masnou, M. J. A. Tanner, Ch. Confavreux, B. Mishu, H. Rasmussen, L. Valenciano, Carlo Pozzilli, S. W. Li, V. Salzman, Y. Vashtang, Massimo Franceschi, M. Severo, G. Deuschl, S. Setien, G. Mariani, A. Protti, J. Castillo, M. J. B. Taphoorn, M. Frontali, I. Milonas, D. Decoq, J. A. Navarro, S. Castellvi-Pel, C. Ertikin, M. Urtasun, Y. Lajat, B. E. Kendall, E. Verdu, B. Gueguen, E. Boisen, R. Couderc, A Danek, JM Stevens, F. Nicoli, L. Feltri, M. L. Vazquez-Andre, J. A. Morgan-Hughes, L. D'Angelo, F. Y. Liew, L. F. Pascual, J. Patrignani Ochoa, Vittorio Martinelli, J. Cophignon, L. Zhang, S. Martin, J. F. Meder, H. C. Buschmann, L. Bertin, J. van Gijn, A. Barreiro, A. Cools, C. Leon, A. Berod, E. A. Anllo, E. Zanette, L. Petrov, R. Barona, B. Gallicchio, P. J. Cozzone, N. Diederich, G. Cancel, L. Schelosky, P. Orizaola, K. Yulug, S. Ozer, Valeria A. Sansone, B. Guiraud-Chaumeil, K. Voigt, P. Labauge, M. Eoli, J. Zhu, J. Aguirre, M. Ferrarini, B. Zyluk, E. Planas, A. Cadilha, C. Tortorella, H. Bismuth, C. E. Counsell, A. Laun, A. Ferlini, Rio J. Montalban, N. Biary, L. Becker, M. Fardeau, M. Poloni, V. M. S. de Bruin, C. Fornada, J. Barros, E. Ganzmann, E. Touze, D. Wallach, J. Peila, H. Fujimura, M. T. Iba-Zizen, G. Macchi, C. Villoslada, R. Gouider, Ph. Rondepierre, P. Grummich, P. Chiodi, C. Conte, M. Michels, P. Annunziata, G. Semana, C. Sommer, J. Vajsar, D. Zekin, J. Kulisevsky, David G. Munoz, B. Jacotot, M. Magoni, A. Luxen, T. Garcia-Silva, S. Di Cesare, Christophe Tzourio, M. Gomori, I. Picomell, L. Santoro, F. Villa, Giovanni Pennisi, T. Ribalta, J. M. Molto, L. Marzorati, P. Loiseau, F. Gemignani, A. Gironell, J. Wissel, A. Prusinski, F. Cailloux, P. Villanueva-Hemandez, P. Cozzone, T. Del Ser, J. Sans-Sabrafen, M. Zappia, P. W. A. Willems, G. Tchernia, D. Gardeur, R. Bauer, F. Palomo, H. Metz, S. Lamoureux, C. Chastang, I. Reinhard, A. Goldfarb, S. Harder, Jordi Río, C. Ozkara, E. Tekinsoy, P. Vontobell, J. De Recondo, M. Rabasa, L. Lacomblez, F. Boon, Dgt Thomas, V. Palma, Renato Mantegazza, A. Dervis, M. Nueckel, B. YalÇinerner, I. Duran, G. Dalla Volta, A. Zubimendi, J. Pinheiro, A. Marbini, Xavier Montalban, H. Wekerle, X. Pereira Monteino, F. Crespo, F. Koskas, N. Battistini, C. Ruiz, H. Offner, J. de Pommery, P. Kanovsky, J. Y. Barnett, J. Pardo, G. Tomei, R. Rene, H. M. Lokhorst, P. Thajeb, H. Bilgin, D. McGehee, R. Fahsold, L. Morgante, Katie Sidle, C. Delwaide, M. N. 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Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg

Subjects
Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published
1994
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9. Editorial

Author

Francesco Scopinaro, Christophe Van de Wiele, Alberto Signore, Rikki N. Waterhouse, and R A Dierckx

Subjects
Pathology, medicine.medical_specialty, business.industry, medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Hypoxia (medical), medicine.symptom, business
Published
2001
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10. Current status and future plans of Nuclear Medicine Procedure Guidelines in Central and Eastern European EANM member societies compared with those in other EANM member societies

Author

J D, Kuyvenhoven, A, Plachcińska, P, Lass, P, van Rijk, and R A, Dierckx

Abstract

The main aim of the EANM Task Group on Quality Assurance and Standardisation is to develop harmonised clinical procedures that are accepted within Europe. In order to achieve an evidence-based analysis of guidelines this Task Group conducted a survey by means of a questionnaire in the 27 EANM member societies in July 1999, which investigated the current status of national guidelines in EANM member societies, specification of the cover and level of these national guidelines, and future desires for national, EANM and SNM guidelines. A reanalysis of the data of this survey was undertaken to evaluate the differences and similarities between 9 Central and Eastern European (CEE) EANM member societies and 18 non-CEE (mainly Western European) EANM member societies with regard to the aforementioned investigated topics. The results of this reanalysis show only minor differences between CEE and non-CEE EANM member societies with regard to the aforementioned topics. Both in CEE and in non-CEE EANM member societies, there is limited coverage of existing guidelines, leaving most procedures uncovered. Although the infrastructure for guideline development is present in both groups, the main explanation for this similarity is the limited advancement of the guideline development process, in both the CEE and non-CEE EANM member societies. Both groups are willing and ready for guideline development at the EANM level, with more concordant than discordant reasons for this. This allows a synchronous implementation of procedure guidelines in CEE EANM member societies.

Published
2003

12. PET visualization of microglia in multiple sclerosis patients using [11C]PK11195

Author

J C, Debruyne, J, Versijpt, K J, Van Laere, F, De Vos, J, Keppens, K, Strijckmans, E, Achten, G, Slegers, R A, Dierckx, J, Korf, and J L, De Reuck

Subjects
Adult, Male, Brain Mapping, Multiple Sclerosis, Age Factors, Antineoplastic Agents, Middle Aged, Isoquinolines, Magnetic Resonance Imaging, Cohort Studies, Radioligand Assay, Thalamus, Recurrence, Parietal Lobe, Humans, Female, Microglia, Tomography, Emission-Computed
Abstract

Activated microglia are involved in the immune response of multiple sclerosis (MS). The peripheral benzodiazepine receptor (PBR) is expressed on microglia and up-regulated after neuronal injury. [11C]PK11195 is a positron emission tomography (PET) radioligand for the PBR. The objective of the present study was to investigate [11C]PK11195 imaging in MS patients and its additional value over magnetic resonance imaging (MRI) concerning the immuno-pathophysiological process. Seven healthy and 22 MS subjects were included. Semiquantitative [11C]PK11195 uptake values were assessed with normalization on cortical grey matter. Uptake in Gadolinium-lesions was significantly increased compared with normal white matter. Uptake in T2-lesions was generally decreased, suggesting a PBR down-regulation. However, uptake values increased whenever a clinical or MR-relapse was present, suggestive for a dynamic process with a transient PBR up-regulation. During disease progression, an increase of normal-appearing white matter (NAWM) uptake was found, propagating NAWM as the possible real burden of disease. In conclusion, [11C]PK11195 and PET are able to demonstrate inflammatory processes with microglial involvement in MS.

Published
2003

13. High F-18 FDG uptake in a paraspinal textiloma

Author

Bieke Lambert, De Winter F, R A Dierckx, De Paepe P, Bart Poffyn, and Wouter Huysse

Subjects
Fluorodeoxyglucose, Adult, Male, medicine.medical_specialty, Lumbar Vertebrae, medicine.diagnostic_test, business.industry, Fdg uptake, Foreign-Body Reaction, Textiles, General Medicine, Chronic osteomyelitis, Positron emission tomography, Fluorodeoxyglucose F18, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Radiology, Radiopharmaceuticals, business, Nuclear medicine, medicine.drug, Tomography, Emission-Computed
Published
2002

14. Iodine-labeled tamoxifen uptake in primary human breast carcinoma

Author

C, Van de Wiele, V, Cocquyt, R, VandenBroecke, F, De Vos, S, Van Belle, K, Dhaene, G, Slegers, and R A, Dierckx

Subjects
Iodine Radioisotopes, Tomography, Emission-Computed, Single-Photon, Carcinoma, Lobular, Tamoxifen, Receptors, Estrogen, Carcinoma, Ductal, Breast, Feasibility Studies, Humans, Breast Neoplasms, Female, Receptors, Progesterone, Immunohistochemistry
Abstract

Assessing tumor uptake and retention of (123)I-labeled tamoxifen (TX) could increase our understanding of TX's action and the mechanisms involved in resistance to the drug.Nine untreated primary breast carcinoma patients underwent whole-body planar and tomographic (SPECT) imaging 30 min and 4-5 h after injection of 185 MBq (123)I-TX. Tumor-to-normal tissue uptake ratios (T/N) derived from SPECT images were related to estrogen receptor (ER) and progesterone receptor (PR) status.In 4 of 9 patients, all of whom were ER+/PR+, (123)I-TX tumor uptake was clearly depicted. In 2 of them, involved axillary lymph nodes were also visualized. T/N consistently increased over time. All ER+/PR- and ER-/PR- tumors as well as 2 ER+/PR+ tumors were (123)I-TX-.These preliminary findings suggest that (123)I-TX is preferentially taken up in alpha-ER+/PR+ breast tumors known to be more likely to respond to endocrine treatment.

Published
2001

15. Biodistribution and dosimetry of (99m)Tc-RP527, a gastrin-releasing peptide (GRP) agonist for the visualization of GRP receptor-expressing malignancies

Author

C, Van de Wiele, F, Dumont, R A, Dierckx, S H, Peers, J R, Thornback, G, Slegers, and H, Thierens

Subjects
Adult, Male, Organotechnetium Compounds, Middle Aged, Receptors, Bombesin, Stomach Neoplasms, Image Processing, Computer-Assisted, Humans, Female, Tissue Distribution, Radiopharmaceuticals, Radiometry, Radionuclide Imaging, Oligopeptides, Aged
Abstract

The aim of this study was to determine the human biodistribution and radiation dosimetry of (99m)Tc-RP527, a promising radioligand for the visualization of gastrin-releasing peptide (GRP) receptor-expressing human malignancies.Whole-body scans were obtained up to 48 h after intravenous injection of 555 MBq (99m)Tc-RP527 in each of 6 subjects. Blood samples were taken at various times up to 48 h after injection. Urine was collected up to 48 h after injection for calculation of renal clearance and whole-body clearance. Time-activity curves were generated for the thyroid, heart, breasts in women, testes in men, and liver by fitting the organ-specific geometric mean counts, obtained from regions of interest, on the respective images as a function of the time after injection. The MIRD formulation was applied to calculate the absorbed radiation dose for various organs.The serial whole-body images showed rapid hepatobiliary excretion, resulting in low background and potentially high-contrast imaging of the thoracic region. Imaging of abdominal tumors may prove problematic, however, because of the extensive bowel activity. (99m)Tc-RP527 was predominantly cleared by the kidneys and to a lesser extent by the gastrointestinal tract. The mean excretion in the urine (+/-SD) at 48 h after injection was 58.3 +/- 5.4 percentage of the injected activity corrected for decay to the time of injection. The highest absorbed doses were received by the excretory organs (i.e., the urinary bladder and gallbladder wall). The average effective dose of (99m)Tc-RP527 was estimated to be 0.0095 mSv/MBq.The biodistribution of (99m)Tc-RP527 revealed low lung, myocardial, and liver uptake, which allowed early imaging of the supradiaphragmatic region with a favorable dosimetry (including effective dose) for administered activities required for SPECT imaging.

Published
2001

16. Receptor imaging in breast carcinoma: future prospects

Author

Guido Sleghers, R A Dierckx, Christophe Van de Wiele, and Simon Van Belle

Subjects
Oncology, medicine.medical_specialty, business.industry, Breast Neoplasms, Receptors, Cell Surface, General Medicine, Prognosis, Hormones, Up-Regulation, Membrane protein, Internal medicine, Radioimmunodetection, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Female, business, Breast carcinoma, Receptor, Radionuclide Imaging
Published
2001

17. Biodistribution and dosimetry of 99mTc-ciprofloxacin, a promising agent for the diagnosis of bacterial infection

Author

Joost Van Durme, Filip Dumont, Keith E. Britton, K. K. Solanki, Hubert Thierens, Frederic De Winter, Guido Slegers, Christophe Van de Wiele, and R A Dierckx

Subjects
Adult, Male, Biodistribution, Urine, Scintigraphy, Radiation Dosage, Effective dose (radiation), Excretion, Pharmacokinetics, Anti-Infective Agents, Ciprofloxacin, medicine, Dosimetry, Humans, Radiology, Nuclear Medicine and imaging, Large intestine, Tissue Distribution, Radionuclide Imaging, medicine.diagnostic_test, business.industry, Technetium, General Medicine, Bacterial Infections, medicine.anatomical_structure, Female, Radiopharmaceuticals, Nuclear medicine, business
Abstract

This study reports on the biodistribution and dosimetry of technetium-99m ciprofloxacin, a radio-ligand developed for the visualisation of bacterial infection. Whole body scans were performed up to 24 h after intravenous injection of 370 MBq 99mTc-ciprofloxacin in three male and three female volunteers. Blood samples were taken at various times up to 24 h after injection. Urine was also collected up to 24 h after injection, allowing calculation of renal clearance and interpretation of whole body clearance. Time-activity curves were generated for the thyroid, heart, liver and whole body by fitting the organ-specific geometric mean counts, obtained from regions of interest. The MIRD formulation was applied to calculate the absorbed radiation doses for various organs. The images showed rapid, predominantly urinary excretion of 99mTc ciprofloxacin, with low to absent brain, lung and bone marrow uptake and low liver uptake and excretion. Accordingly, imaging conditions are excellent for both the thoracic and the abdominal region, even at early time points (60 min) post injection. In none of the volunteers was the gallbladder visualised. Approximately 60% of the injected activity was recovered in urine by 24 h post injection. The highest absorbed doses were received by the urinary bladder wall, the thyroid, the upper large intestine, the lower large intestine and the uterus. The estimated mean effective dose for the adult subject, taking into account the weight factors of the ICRP60 publication, was 0.0083 mSv/MBq. The amount of 99mTc ciprofloxacin required for adequate planar and tomographic imaging results in an acceptable effective dose to the patient.

Published
2001

18. Imaging tumour hypoxia: where are we?

Author

C, Van De Wiele, A, Signore, F, Scopinaro, R, Waterhouse, and R A, Dierckx

Subjects
Neoplasms, Humans, Radionuclide Imaging, Cell Hypoxia
Published
2001

19. Assessing the performance of SPM analyses of spect neuroactivation studies. Statistical Parametric Mapping

Author

P, Lahorte, S, Vandenberghe, K, Van Laere, K, Audenaert, I, Lemahieu, and R A, Dierckx

Subjects
Tomography, Emission-Computed, Single-Photon, Brain Mapping, Phantoms, Imaging, Cerebrovascular Circulation, Data Interpretation, Statistical, Image Processing, Computer-Assisted, Brain, Humans, Mathematical Computing, Synaptic Transmission
Abstract

Several simulations of SPECT neuroactivation studies have been performed in order to determine the influence of both study size and activation focus characteristics on the detection of brain activation foci following a pixel-based statistical analysis. This was achieved by developing a methodology based on the Hoffman software brain phantom, SPECT acquisition simulation software, standard reconstruction software, and the Statistical Parametric Mapping (SPM96) package. We present results on the minimal activation levels required for focus detection. Furthermore, the improved sensitivity of the analysis resulting from the use of an iterative reconstruction technique (OSEM) with regard to the classical filtered backprojection (FBP) is assessed quantitatively, and the various physical, processing, and physiological parameters that potentially influence the detection of foci are discussed. Finally, the influence is investigated of the height threshold as implemented in SPM96 upon the size of the detected foci. Practical guidelines are proposed with regard to the number of subjects per group for SPECT activation studies following the split-dose design.

Published
2000

20. A survey of guidelines in 27 EANM associated societies by the EANM Task Group on Quality Assurance and Standardisation. European Association of Nuclear Medicine

Author

J D, Kuyvenhoven, E, Busemann Sokole, P, van Rijk, M, Clausen, F, Jamar, G, Slegers, H, Thierens, P, Cosgriff, and R A, Dierckx

Subjects
Europe, Quality Assurance, Health Care, Data Collection, Practice Guidelines as Topic, Nuclear Medicine, Societies, Medical
Abstract

The main aim of the EANM Task Group on Quality Assurance and Standardisation is to develop harmonised clinical procedures that are accepted within Europe. In order to achieve an evidence-based analysis of guidelines in the 27 EANM member societies, a survey was conducted. A questionnaire in mid 1999 investigated three major questions: (1) current status of national guidelines in EANM member societies, (2) specification of the cover and level of these national guidelines, and (3) future desires for national, EANM and SNM guidelines. The complete response rate was 96% (26/27). Guidelines are required by 19 of 27 member societies and have been initiated by 16 member societies. Guidelines are provided by 13 member societies, generally in the national language. In ten societies, specialists other than nuclear medicine physicians, mostly physicists and radiopharmacists, take the lead on some guidelines. Moreover, in some national societies there is active collaboration with other medical societies when writing guidelines, particularly cardiology societies. Currently, only 18% of the necessary procedure guidelines are covered. Compared with a survey conducted in 1993 by the EANM Committee on Quality Assurance and Standardisation, slow progress has been made in this regard, but compared with a survey conducted by the same committee in 1996 in 23 EANM member societies, the number of member societies providing guidelines has approximately doubled. Moreover, 26 of 27 member societies share a commitment for future development of guidelines and 21 of 27 prefer EANM guidelines to national guidelines. The results of this questionnaire justify the need for close co-operation between EANM, EANM member societies, the EANM Task Group on "Quality Assurance and Standardisation" and the Guideline Committee of the SNM. The clinical priorities are considered to be cardiac, renal and brain procedures.

Published
2000

21. Is 99mTc human immunoglobulin G scintigraphy (HIG-scan) useful for the detection of spinal inflammation in ankylosing spondylitis?

Author

K, de Vlam, C, Van de Wiele, H, Mielants, R A, Dierckx, and E M, Veys

Subjects
Adult, Male, Tomography, Emission-Computed, Single-Photon, Organotechnetium Compounds, Middle Aged, Technetium Tc 99m Medronate, Diagnosis, Differential, Immunoglobulin G, Osteoarthritis, Humans, Female, Spondylitis, Ankylosing, Radiopharmaceuticals, Aged
Abstract

To determine the effectiveness of technetium-99m labelled polyclonal human immunoglobulin G (HIG-scan) scintigraphy to detect spinal inflammation in patients with ankylosing spondylitis.Six ankylosing spondylitis (AS) patients with inflammatory axial pain and 3 spinal osteoarthritis (OA) patients with mechanical axial pain underwent an HMDP scan and an HIG-scan.In both AS and spinal OA patients complaining of axial back pain, mechanical and inflammatory axial pain, bone scintigraphy revealed foci of markedly increased tracer accumulation. An HIG-scan of the region of increased uptake on bone scintigraphy did not reveal increased tracer accumulation in either group of patients.The data suggest that the HIG-scan is not useful in detecting inflammatory spinal lesions in ankylosing spondylitis.

Published
2000

22. Adaptive response in patients treated with 131I

Author

M A, Monsieurs, H M, Thierens, A M, Vral, C, Van De Wiele, L I, De Ridder, and R A, Dierckx

Subjects
Chromosome Aberrations, Male, Reproducibility of Results, Dose-Response Relationship, Radiation, Middle Aged, Adaptation, Physiological, Radiation Tolerance, Thyroid Diseases, Iodine Radioisotopes, Thyrotoxicosis, Humans, Female, Lymphocytes, Cobalt Radioisotopes
Abstract

The aim of this study was to investigate whether an adaptive response (defined as the induction of radiation tolerance after a small dose of radiation) could be observed in peripheral blood lymphocytes of patients treated with 1311 for thyroid disease.For each patient, blood samples were taken immediately before and 1 wk after 131I administration. Each blood sample was divided into 3 fractions and the fractions were subsequently irradiated in vitro with 0, 0.5, and 1.0 Gy 60Co gamma-rays. After blood culture for 70 h, cells were harvested and stained with Romanowsky-Giemsa and micronuclei were counted in 1000 binucleated cells. The increase in micronuclei by the in vitro irradiation of the blood samples taken before and after therapy was compared. In this setup, an adaptive response is represented by a significant decrease of the in vitro induced micronucleus yield after therapy compared with that before therapy. The iodine therapy can be considered as an in vivo adaptation dose, after which the subsequent in vitro irradiation acts as a challenge dose. To investigate the reproducibility of the method, 2 subsequent blood samples of healthy volunteers were taken 7 d apart. Irradiation and cell culture were performed as described.In 8 of 20 patients, a significant (P = 0.0002) decrease was found in the in vitro induced micronucleus yield in the blood sample taken 1 wk after 1311 administration compared with that of the blood sample taken before therapy. No significant (P0.1) differences were observed between these 8 patients and the other patients when the number of micronuclei induced in vivo by the iodine treatment and the resulting equivalent total body dose were compared. None of the control subjects showed a significant change in micronucleus yield after in vitro irradiation between both blood samples taken 1 wk apart.The iodine treatment can act as an in vivo adaptation dose and can induce an adaptive response that is observed by a decrease of the cytogenetic damage in peripheral blood lymphocytes after in vitro irradiation as a challenge dose. A large interindividual difference was observed.

Published
2000

23. Accurate differentiation of parkinsonism and essential tremor using visual assessment of [

Author

Hani T S, Benamer, Jim, Patterson, Donald G, Grosset, J, Booij, K, de Bruin, E, van Royen, J D, Speelman, M H I M, Horstink, H J W A, Sips, R A, Dierckx, J, Versijpt, D, Decoo, C, Van Der Linden, D M, Hadley, M, Doder, A J, Lees, D C, Costa, S, Gacinovic, W H, Oertel, O, Pogarell, H, Hoeffken, K, Joseph, K, Tatsch, J, Schwarz, and V, Ries

Published
1999

24. Laparoscopic adjustable silicone gastric banding leakage assessed by 99mTc-pertechnetate scintigraphy

Author

A C, Van den Eeckhaut, G M, Villeirs, C, Van de Wiele, J J, Versijpt, P, Pattyn, and R A, Dierckx

Subjects
Adult, Postoperative Complications, Gastroplasty, Silicones, Humans, Female, Laparoscopy, Middle Aged, Radiopharmaceuticals, Radionuclide Imaging, Sodium Pertechnetate Tc 99m
Abstract

The purpose of this study was to assess the value of 99mTc-pertechnetate scanning in the diagnosis of gastric banding leaks.Three patients with morbid obesity received laparoscopic adjustable silicone gastric banding (ASGB), but no significant weight reduction was obtained. To exclude band leakage as the cause, four scintigraphic procedures were performed, consisting of imaging the upper abdomen 30 min and 3 h after injection of 3 mL (111 MBq) pertechnetate solution into the ASGB reservoir. In one patient, the integrity of the ASGB device was first assessed radiologically after injection of a water-soluble contrast agent into the ASGB reservoir.In two normally functioning ASGB devices, radiotracer was observed within the device on both early and late images. In two patients with a surgically proven small leak in the reservoir or the connecting tube, late images showed little tracer in the reservoir and the connecting tube. However, intense tracer accumulation was observed in the stomach as a result of resorption of pertechnetate in the subcutaneous or peritoneal blood vessels and subsequent gastric uptake. In one of the latter patients, radiographic assessment of the ASGB device revealed no abnormalities.99mTc-pertechnetate scanning is a valuable technique to diagnose small leaks in an ASGB device.

Published
1999

25. Biodistribution and dosimetry of carbon-11-methoxyprogabidic acid, a possible ligand for GABA-receptors in the brain

Author

P, Santens, F, De Vos, H, Thierens, D, Decoo, G, Slegers, R A, Dierckx, and J, De Reuck

Subjects
Adult, Male, Mice, Receptors, GABA, Animals, Brain, Humans, Tissue Distribution, Carbon Radioisotopes, gamma-Aminobutyric Acid, Tomography, Emission-Computed
Abstract

Carbon-11-methoxyprogabidic acid (11C-MPGA) was recently synthetized as a possible ligand for PET studies of gamma-amino-butyric acid (GABA) receptors in the brain. The data for human absorbed dose estimates are calculated based on the biodistribution of 11C-MPGA in mice and humans.Eighteen mice were killed at preset time intervals after an intravenous bolus injection of 3.7 MBq (100 microCi) 11C-MPGA. Time-activity curves were reconstructed for several organs. Three healthy men each had whole-body PET scans after an intravenous bolus injection of 37 MBq (1 mCi) to determine activity in the critical organs. Animal data were fitted into these human findings to calculate residence times, and the MIRDOSE 3 protocol was used to calculate the radiation absorbed dose.Animal studies demonstrated a rapid distribution of 11C-MPGA in several organs. The highest activity was detected in the intestines, liver and kidneys. Brain activity was low throughout compared to these organs. The human whole-body study yielded similar results, with the intestines, liver and kidneys showing the highest activity. The estimated dose to the urinary bladder compartment turned out to be significant. The mean effective dose was 4.8 microSv/MBq (s.d.= 0.5 microSv/MBq).PET studies using 185 MBq (5 mCi) 11C-MPGA are within the International Commission on Radiological Protection risk Category II for healthy volunteers.

Published
1998

26. Bone scintigraphy of the hands in early stage lupus erythematosus and rheumatoid arthritis

Author

C, Van de Wiele, F, Van den Bosch, H, Mielants, M, Simons, E M, Veys, and R A, Dierckx

Subjects
Adult, Male, Synovitis, Adolescent, Middle Aged, Hand, Arthralgia, Arthritis, Rheumatoid, Diagnosis, Differential, Humans, Lupus Erythematosus, Systemic, Female, Radionuclide Imaging, Aged, Retrospective Studies
Abstract

To evaluate retrospectively the discriminatory value of bone scintigraphy, especially spot images of the hands, in differentiating early stage systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).Data from 19 patients with SLE (3 men, 16 women) and 20 patients with RA (6 men, 14 women), presenting with early stage articular disease (arbitrarily defined as articular complaints for no longer than 3 mo), were reviewed. At this stage, radiographs were normal in all patients. In all 39 patients, total body bone scintigraphy with spot images of the hands was performed as part of a complete diagnostic investigation. For differentiation between SLE and RA in early disease stage, less extensive semiquantitative description in 3 categories (normal, diffuse mildly increased, and (multi)focal moderately to markedly increased tracer accumulation) proved to be sufficient. Locations of bone scintigraphic findings were correlated to clinical findings.In RA, bone scintigraphy revealed foci of moderate to markedly increased tracer accumulation, corresponding to the sites of clinical synovitis in all patients. In 10 patients with SLE, bone scintigraphy images of the hands were normal, and in 9 patients diffuse mildly increased tracer accumulation was observed.The data suggest bone scintigraphy may be useful to differentiate SLE from RA in early stage disease.

Published
1997

28. Thallium-201 accumulation in myositis ossificans and in juxta-articular ossification

Author

K, Osmanagaoglu, J, Kuyvenhoven, R A, Dierckx, J, Hamers, C, Cuvelier, D, Uyttendaele, and M, Simons

Subjects
Adult, Male, Osteosarcoma, Ossification, Heterotopic, Middle Aged, Technetium Tc 99m Medronate, Diagnosis, Differential, Thallium Radioisotopes, Myositis Ossificans, Evaluation Studies as Topic, Humans, Female, Muscle, Skeletal, Radionuclide Imaging
Abstract

We present the findings on 201Tl and 99mTc-MDP scintigraphy in three patients suffering from heterotopic ossification (two patients presenting with myositis ossificans and one patient presenting with juxta-articular ossification in combination with myositis ossificans). Since resection of the lesions has to be delayed until stabilization, 99mTc-MDP is often used as a parameter of lesional activity, although it is not optimal. For this clinical problem, we evaluated 201Tl scintigraphy as a marker of metabolic activity. In addition to the well-documented uptake of 99mTc-MDP, marked accumulation of 201Tl was observed in all heterotopic ossification sites. Hence, our results support the use of 201Tl scintigraphy in the therapeutic management and monitoring of conditions associated with ectopic ossification. On the other hand, although myositis ossificans is sometimes clinically, radiographically and even histologically confused with extraosseous osteogenic sarcoma, 201Tl accumulation may not be a helpful factor in the differential diagnosis due to the presence of tracer accumulation in both disorders.

Published
1995

29. Technetium-99m HMPAO SPET in acute supratentorial ischaemic infarction, expressing deficits as millilitre of zero perfusion

Author

B.A. Pickut, I.M. Dierckx, André Dobbeleir, R. A. Dierckx, A. Vervaet, W. Deberdt, P.P. De Deyn, L. Timmermans, and J. Vandevivere

Subjects
Male, medicine.medical_specialty, Time Factors, Tentorium cerebelli, Infarction, Sensitivity and Specificity, Central nervous system disease, Technetium Tc 99m Exametazime, Double-Blind Method, Oximes, medicine, Humans, Radiology, Nuclear Medicine and imaging, Stroke, Aged, Computer. Automation, Tomography, Emission-Computed, Single-Photon, business.industry, Glasgow Coma Scale, General Medicine, Cerebral Infarction, Organotechnetium Compounds, medicine.disease, Interim analysis, Piracetam, Cerebrovascular Circulation, Female, Radiology, Nuclear medicine, business, Tomography, X-Ray Computed, Perfusion, Technetium-99m
Abstract

A comparative interim analysis was performed of clinical parameters, computed tomographic (CT) scan results and technetium-99m hexamethylpropylene amine oxime single-photon emission tomography (SPET) findings obtained within 12 h of acute supratentorial ischaemic infarction. First, the applicability for SPET semiquantification in this study of the ''method of Mountz'', simultaneously accounting for extent and degrees of hypoperfusion by expressing deficits as millilitre of zero perfusion, was considered. Next, the relative contributions of perfusion SPET and CT scan in the acute stage of ischaemic infarction were compared in 27 patients (mean age 68.8 years). Finally, the correlation of SPET lesions with clinical parameters at onset was evaluated. The method of Mountz represents a workable, accurate virtual parameter, with the assumption that the contralateral brain region remains uninvolved. Interobserver reproducibility in 12 SPET studies, with lesions varying between 6 and 369 cc, showed a correlation coefficent r of 0.99. In practice, because of inconstant dis tribution of activities in the brain, the method can only be applied slice by slice and not on the total global volume. While the mean delay since the onset of symptomatology was approximately 7 h for both SPET and CT scan, SPET showed lesions concordant with the clinical neurological findings in 100% and CT scan in only 48%. One could hypothesize that SPET examinations performed later would show larger functional defects, because of the development of additional functional changes secondary to biochemical alterations. However, in this regard no statistically significant differences were found between two subproups, taking the median of delay before SPET examination as cut-off. Finally, when com paring the volumes of SPET lesions during the acute stage with clinical parameters, a statistically significant correlation (P

Published
1995

30. Repeat thallium-201 SPECT in cerebral lymphoma

Author

F, Borggreve, R A, Dierckx, R, Crols, R, Mathijs, B, Appel, J, Vandevivere, P, Mariën, J J, Martin, and P P, De Deyn

Subjects
Male, Neurologic Examination, Tomography, Emission-Computed, Single-Photon, Thallium Radioisotopes, Lymphoma, Brain Neoplasms, Injections, Intravenous, Humans, Autopsy, Tomography, X-Ray Computed, Aged, Frontal Lobe
Abstract

The authors report on the contribution of Thallium-201 brain SPECT in the diagnosis and follow-up of a non-immunosuppressed patient, presenting with primary cerebral lymphoma. The tumoral process was at first not diagnosed on CT-scan, but Thallium-201 SPECT suggested a tumoral invasion. During corticosteroid treatment the tumor volume on CT-scan decreased, while on Thallium-201 SPECT there was an enhancement of the accumulation and an increasing tumor to non-tumor ratio. These scintigraphical findings more closely reflected the clinical course and the postmortem results.

Published
1993

31. Imaging of Giant Cell Arteritis

Author

De Winter F, Van de Wiele C, R A Dierckx, Mirko Petrovic, Marcel Afschrift, and Dirk Vogelaers

Subjects
Male, medicine.medical_specialty, business.industry, Giant Cell Arteritis, General Medicine, Middle Aged, FDG-Positron Emission Tomography, medicine.disease, Giant cell arteritis, Thoracic Arteries, Treatment Outcome, Fluorodeoxyglucose F18, medicine, Humans, Radiology, Nuclear Medicine and imaging, Radiology, Radiopharmaceuticals, Nuclear medicine, business, Follow-Up Studies, Splenic Diseases, Tomography, Emission-Computed
Published
2000
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32. Evolution of technetium-99m-HMPAO SPECT and brain mapping in a patient presenting with echolalia and palilalia

Author

R A, Dierckx, J, Saerens, P P, De Deyn, W, Verslegers, P, Marien, and J, Vandevivere

Subjects
Tomography, Emission-Computed, Single-Photon, Brain Mapping, Time Factors, Brain, Parkinson Disease, Echolalia, Organotechnetium Compounds, Frontal Lobe, Technetium Tc 99m Exametazime, Parietal Lobe, Oximes, Humans, Female, Aged
Abstract

A 78-yr-old woman presented with transient echolalia and palilalia. She had suffered from Parkinson's disease for 2 yr. Routine laboratory examination showed hypotonic hyponatremia, but was otherwise unremarkable. Brain mapping revealed a bifrontal delta focus, more pronounced on the right. Single photon emission computed tomography (SPECT) of the brain with technetium-99m labeled d,l hexamethylpropylene-amine oxime (99mTc-HMPAO), performed during the acute episode showed relative frontoparietal hypoactivity. Brain mapping performed after disappearance of the echolalia and palilalia, which persisted only for 1 day, was normal. By contrast, SPECT findings persisted for more than 3 wk. Features of particular interest in the presented patient are the extensive defects seen on brain SPECT despite the absence of morphologic lesions, the congruent electrophysiologic changes and their temporal relationship with the clinical evolution.

Published
1991

33. Delayed Epiphyseal Closure Attributable to Androgen Deficiency

Author

K Osmanagaoglu, Kurt Audenaert, R A Dierckx, and C. Van de Wiele

Subjects
Adult, Male, medicine.medical_specialty, medicine.drug_class, Bone and Bones, Craniopharyngioma, Age Determination by Skeleton, Internal medicine, Androgen deficiency, medicine, Humans, Pituitary Neoplasms, Testosterone, Radiology, Nuclear Medicine and imaging, Radionuclide Imaging, Bone pain, medicine.diagnostic_test, business.industry, Bone age, General Medicine, Androgen, medicine.disease, Pubic hair, medicine.anatomical_structure, Endocrinology, Sella turcica, Bone scintigraphy, Androgens, medicine.symptom, business, Epiphyses
Abstract

A 31-year-old man who underwent incomplete surgical removal of a craniopharyngioma at the age of 14 years was seen because of diffuse bone pain. Clinical examination showed scarce axillary and pubic hair in addition to insufficiently enlarged testes. Whole-body bone scintigraphy showed persisting generalized growth plate activity, consistent with a skeletal age of a 14 to 15-year-old boy. Increased tracer accumulation at the level of the sella turcica caused by the presence of a stable residual hypophyseal tumor mass, as documented by serial CT-scans, was found. The skeletal age according to radiography of the total skeleton was in agreement with the scintigraphic findings. Because androgens initially stimulate growth and subsequently terminate growth by causing the epiphyses to fuse to the long bones (epiphyseal closure), the presented findings suggest androgen deficiency after extirpation of the craniopharyngioma at age 14 years. This was confirmed by biochemical analysis, showing a testosterone level of 0.2 nmol/L (normal, 10-40 nmol/L).

Published
1997
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35. Exercise training after primary angioplasty

Author

R A Dierckx, Yvo Taeymans, P Gheeraert, J. De Sutter, G. De Backer, and C. Van de Wiele

Subjects
medicine.medical_specialty, business.industry, Physical therapy, Primary angioplasty, Training (meteorology), Medicine, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business
Published
1999
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36. Whole-Body Bone Scan Findings in X-Linked Hypophosphatemia

Author

C. Van de Wiele, M. Simons, L. Weynants, R A Dierckx, and J. M. Kaufman

Subjects
Adult, musculoskeletal diseases, medicine.medical_specialty, Arthritis, Rickets, urologic and male genital diseases, Scintigraphy, Gastroenterology, Bone and Bones, Internal medicine, Osteoarthritis, medicine, Humans, Radiology, Nuclear Medicine and imaging, Radionuclide Imaging, Hypophosphatemia, Familial, Osteomalacia, medicine.diagnostic_test, business.industry, Metabolic disorder, nutritional and metabolic diseases, General Medicine, medicine.disease, X-linked hypophosphatemia, stomatognathic diseases, Endocrinology, business, Whole body, Hypophosphatemia
Abstract

X-linked hypophosphatemia, also called phosphate diabetes, is the most frequent form of inherited rickets in North American. In a series of 38 untreated adult X-linked hypophosphatemia patients, Hardy et al suggested that scintigraphic findings may be attributed solely to degenerative arthritis. However, the authors present a 31-year old, drug-free, X-linked hypophosphatemia patient, in whom bone scan findings were more compatible with osteomalacia and secondary degenerative arthritis, rather than with isolated degenerative arthritis. These findings are in agreement with the biochemical and histologic proof of active osteomalacia in untreated adult X-linked hypophosphatemia patients, provided by Reid et al. The first whole-body bone images of X-linked hypophosphatemia are presented.

Published
1996
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38. Progressive Systemic Sclerosis and Nervous System Involvement

Author

F. Gerstenbrand, R. A. Dierckx, Franz Aichner, and P. Fritsch

Subjects
musculoskeletal diseases, Nervous system, medicine.medical_specialty, Pathology, Electrodiagnosis, medicine.diagnostic_test, business.industry, Central nervous system, Progressive systemic sclerosis, medicine.disease, Connective tissue disease, eye diseases, Scleroderma, Surgery, stomatognathic diseases, medicine.anatomical_structure, Peripheral neuropathy, stomatognathic system, Neurology, medicine, Neurology (clinical), business
Abstract

Nervous system involvement in progressive systemic sclerosis (PSS) has been considered rare compared to other collagen diseases. We present 14 additional cases of PSS with neurological manifestations.

Published
1987
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39. New perspectives in acute spinal epidural abscess. Illustrated by two case reports

Author

F. Aichner, E. Schmutzhard, R. A. Dierckx, F. Gerstenbrand, and J. Willeit

Subjects
Anesthesia, Epidural, Epidural Space, Male, Reoperation, medicine.medical_specialty, Neurology, Magnetic Resonance Spectroscopy, Spinal epidural abscess, Postoperative Complications, Recurrence, medicine, Humans, Anesthetics, Local, Abscess, Neuroradiology, medicine.diagnostic_test, business.industry, Interventional radiology, Middle Aged, medicine.disease, Surgery, Vertebral canal, Spinal Diseases, Neurology (clinical), Neurosurgery, business, Infiltration (medical)
Abstract

The histories of two patients with spinal epidural abscess are reported. Attention is drawn to the route of infection by means of direct inoculation of pathogens in the wake of paravertebral infiltration of local anaesthetics for relieving lower backpain, furthermore we emphasize the rare occurrence of a relapsing acute spinal epidural abscess. Additionally the diagnostic superiority of nuclear magnetic resonance tomography is described in a patient known to be allergic to commonly used contrast material.

Published
1986

40. Progressive systemic sclerosis and nervous system involvement. A review of 14 cases

Author

R A, Dierckx, F, Aichner, F, Gerstenbrand, and P, Fritsch

Subjects
Male, Scleroderma, Systemic, Central Nervous System Diseases, Electrodiagnosis, Humans, Peripheral Nervous System Diseases, Female, Syndrome, Middle Aged, Aged
Abstract

Nervous system involvement in progressive systemic sclerosis (PSS) has been considered rare compared to other collagen diseases. We present 14 additional cases of PSS with neurological manifestations. Primary involvement of the peripheral nerves could be detected in 4 of 14 patients and is documented by electromyo- and electroneurographical examinations. Central nervous system (CNS) manifestations directly related to PSS are a rarity, which may reflect the lack of collagen in the brain, histological differences between cerebral and other arteries and the immunological particularity of the brain. There may have been a direct relationship between CNS involvement and PSS in only one patient presenting with an overlap-syndrome.

Published
1987

41. Spinal Extradural Lipomas: A Report on Three Patients

Author

R. A. Dierckx, Pallua A, F. Gerstenbrand, U. Mayr, and F. Aichner

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Spinal dysraphism, business.industry, Multiple sclerosis, Magnetic resonance imaging, Computed tomography, Lipoma, medicine.disease, Disc protrusion, Lumbar, medicine, Spinal metastasis, Radiology, business
Abstract

Intraspinal extradural lipoma, not associated with spinal dysraphism, comprises 0.4%–0.8% of all intraspinal tumours. The tumours are found mostly in the mid-thoracic region, can present at all ages and have no sex predominance. The clinical picture may simulate a disc Protrusion, a spinal metastasis and multiple sclerosis. We report on three recent cases in which spinal extradural lipoma was diagnosed at the lumbar and sacral level by computerized tomographic (CT) scan. Magnetic resonance imaging (MRI) provided no additional Information, while plain X-rays of the spine and myelographic studies were not contributive. This tumour can be detected easily by CT scan because of the hypodensity of the fatty mass. Measuring density values characteristic of fat allows a specific diagnosis to be made pre-operatively.

Published
1987
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42. Non-traumatic subdural hygroma

Author

R A, Dierckx, M, Bruyland, Z, Nuyens, T, Stadnik, C, Solheid, and G, Ebinger

Subjects
Aged, 80 and over, Drainage, Humans, Female, Meningitis, Coma, Tomography, X-Ray Computed, Subdural Effusion, Aged
Abstract

Subdural hygroma consists of a cerebrospinal fluid-like subdural fluid collection with a low oncotic pressure in comparison with venous blood. Its etiology and pathophysiology, which may be different from other subdural fluid collections, are reviewed. We report the clinical history of a 80-year-old woman with a bilateral frontal subdural hygroma. Serial CT-scanning demonstrated a rapid increase in volume after two years of slow evolution. In our patient dehydration may have been the triggering factor. The course of non-traumatic subdural hygroma is not well known. This report illustrates that subdural hygroma can have a dramatic evolution and that therapeutic decisions in these patients should be based on repeated CT-scans.

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