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BACKGROUND: Skin cancer is a public health problem that is increasing statistically, likely due to environmental changes, different lifestyles, early detection and registration of cases thereof; so it is important to know the epidemiological behavior of this dermatosis. OBJECTIVE: To know the epidemiological behavior and histological variety of different cancers in the ISSSTE in Nuevo Leon, Mexico. MATERIAL AND METHOD: A retrospective study was conducted in patients with cutaneous malignant neoplasm biopsy. Information pathology reports were obtained during the study period and verified with medical records. RESULTS: 269 patients with skin cancer, of which 191 (71%) were basal cell carcinoma, 41 (15%) squamous, 14 (5%) melanoma and 23 cases (9%), other neoplasms. CONCLUSION: The incidence and histological variety found in our study were similar to the rest of the country and published worldwide. More epidemiological studies on skin cancer in Mexico are required. [ABSTRACT FROM AUTHOR]