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Key points Obesity can disrupt the structure and function of organ systems, including the olfactory system that is important for food selection and satiety. We designed dietary treatments in mice such that mice received fat, but the total calories provided were the same as in control diets so that they would not gain weight or increase adipose tissue. Mice that were not obese but consumed isocaloric fatty diets still lost olfactory neuronal circuits, had fewer numbers of olfactory neurons, had an elevation in inflammatory signals, and an intermediate ability to clear glucose (prediabetes). Mice were allowed access to running wheels while consuming fatty diets, yet still lost olfactory structures. We conclude that a long-term imbalance in nutrition that favors fat in the diet disrupts the olfactory system of mice in the absence of obesity. Abstract Excess nutrition causes loss of olfactory sensory neurons (OSNs) and reduces odor discrimination and odor perception in mice. To separate diet-induced obesity from the consumption of dietary fat, we designed pair-feeding experiments whereby mice were maintained on isocaloric diets for 5 months that prevented increased fat storage. To test our hypothesis that adiposity was not a prerequisite for loss of OSNs and bulbar projections, we used male and female mice with an odorant receptor-linked genetic reporter (M72tauLacZ; Olfr160) to visualize neural circuitry changes resulting from fat in the diet. Simultaneously we monitored glucose clearance (diagnostic for prediabetes), body fat deposition, ingestive behaviors, select inflammatory markers, and energy metabolism. Axonal projections to defined olfactory glomeruli were visualized in whole-mount brains and the number of OSNs were manually counted across whole olfactory epithelia. After being pair fed a moderately high-fat (MHF) diet, mice of both sexes had body weight, adipose deposits, energy expenditure, respiratory exchange ratios, and locomotor activity that were unchanged from control-fed mice. Despite this, they were still found to lose OSNs and associated bulbar projections. Even with unchanged adipocyte storage, pair-fed animals had an elevation in TNF cytokines and an intermediate ability for glucose clearance. Albeit improving health metrics, access to voluntary running while consuming an ad libitum fatty diet, still precipitated a loss of OSNs and associated axonal projections for male mice. Our results support that long-term macronutrient imbalance can drive anatomical loss in the olfactory system regardless of total energy expenditure. This article is protected by copyright. All rights reserved.

Background In order to support primary care during the first pandemic wave (March 2020), the Italian Government instituted multiprofessional health teams called “USCA” (Special Continuity Care Units), which ensured continuity of care for COVID-19 patients who do not need hospitalization. The aim of our study was to compare the volumes of USCA service utilization in Florence (Tuscany, Italy) during the peak of home visits of three pandemic waves. Methods This single-center study followed a retrospective cross-sectional design. The USCA of the Heath District of Florence served a population of 366,190 people. The following data were collected: home medical visits, nursing home (NH) visits, visits in health-care hotels. The peak periods of three epidemic waves were considered in the analyses: the second wave (23 October - 20 November 2020), the third wave (25 March - 22 April 2021), and the Omicron period (27 December 2021 - 6 February 2022). The maximum 7-day moving averages of the daily number of visits during the three periods were calculated. Relative percent differences for visits comparing the considered periods were computed. Results Home visits during the third pandemic wave increased by 14% compared to the second wave (second wave: N = 1370, third wave: N = 1562), while a decrease was observed during the Omicron period (Omicron vs third wave: -21%; peak value: 41 vs 60). Visits in health-care hotels during the third wave doubled compared to the second wave. After the start of the COVID-19 vaccination campaign, NH visits steeply declined (third wave vs second wave: -95%; N = 323 vs 15; peak value= 14 vs 2 visits per day). During the Omicron period, NH visits increased by almost four times compared to the third wave period. Conclusions The USCA service utilization was significant in all the analyzed periods. In a pandemic context, it is necessary to strengthen primary care services such as USCA, which have proved to respond to rapidly changing health needs. Key messages • The USCA service is an innovative model of integrated home care that has proved to respond to rapidly changing health needs during all phases of the COVID-19 pandemic. • The USCA service utilization was significant during all phases of the pandemic. The USCA service has introduced new ways of working and new relationships between services in primary care.

Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a five-year survival of less than 6%. Chronic pancreatitis (CP), an inflammatory process in of the pancreas, is a strong risk factor for PDAC. Several genetic polymorphisms have been discovered as susceptibility loci for both CP and PDAC. Since CP and PDAC share a consistent number of epidemiologic risk factors, the aim of this study was to investigate whether specific CP risk loci also contribute to PDAC susceptibility. We selected five common SNPs (rs11988997, rs379742, rs10273639, rs2995271 and rs12688220) that were identified as susceptibility markers for CP and analyzed them in 2,914 PDAC cases, 356 CP cases and 5,596 controls retrospectively collected in the context of the international PANDoRA consortium. We found a weak association between the minor allele of the PRSS1-PRSS2-rs10273639 and an increased risk of developing PDAC (ORhomozygous = 1.19, 95% CI 1.02–1.38, p = 0.023). Additionally all the SNPs confirmed statistically significant associations with risk of developing CP, the strongest being PRSS1-PRSS2-rs10273639 (ORheterozygous = 0.51, 95% CI 0.39–0.67, p = 1.10 × 10−6) and MORC4-rs 12837024 (ORhomozygous = 2.07 (1.55–2.77, ptrend = 0.7 × 10−11). Taken together, the results from our study do not support variants rs11988997, rs379742, rs10273639, rs2995271 and rs12688220 as strong predictors of PDAC risk, but further support the role of these SNPs in CP susceptibility. Our study suggests that CP and PDAC probably do not share genetic susceptibility, at least in terms of high frequency variants. © 2017 UICC

We present the nature of 50 hard X-ray emitting objects unveiled through an optical spectroscopy campaign performed at seven telescopes in the northern and southern hemispheres. These objects were detected with Swift-BAT and listed as of unidentified nature in the 54-month Palermo BAT catalogue. In detail, 45 sources in our sample are identified as active galactic nuclei of which, 27 are classified as type 1 (with broad and narrow emission lines) and 18 are classified as type 2 (with only narrow emission lines). Among the broad-line emission objects, one is a type 1 high-redshift quasi-stellar object, and among the narrow-line emission objects, one is a starburst galaxy, one is a X-ray bright optically normal galaxy, and one is a low ionization nuclear emission line region. We report 30 new redshift measurements, 13 confirmations and 2 more accurate redshift values. The remaining five objects are galactic sources: three are Cataclismic Variables, one is a X-ray Binary probably with a low mass secondary star, and one is an active star., 23 pages, 13 figures, accepted for publication in A&A

CAPS is the acronym for chemically assisted primary sedimentation, which consists of adding chemicals to raw urban wastewater to increase the efficacy of coagulation, flocculation and sedimentation. The principal benefits of CAPS are: upgrading of urban wastewater treatment plants; increasing efficacy of primary sedimentation; and the major production of energy from the anaerobic digestion of primary sludge. Metal coagulants are usually used because they are both effective and cheap, but they can cause damage to the biological processes of anaerobic digestion. Generally, biodegradable compounds do not have these drawbacks, but they are comparatively more expensive. Both metal coagulants and biodegradable compounds have preferential and penalizing properties in terms of CAPS application. The problem can be solved by means of a multi-criteria analysis. For this purpose, a series of tests was performed in order to compare the efficacy of several organic and mixed-organic polymers with that of polyaluminium chloride (PACl) under specific conditions. The multi-criteria analysis was carried out coupling the simple additive weighting method with the paired comparison technique as a tool to evaluate the criteria priorities. Five criteria with the following priorities were used: chemical oxygen demand (COD) removalturbidity, SV60coagulant dose, and coagulant cost. The PACl was the best alternative in 70% of the cases. The CAPS process using PACl made it possible to obtain an average COD removal of 68% compared with 38% obtained, on average, with natural sedimentation and 61% obtained, on average, with the best PACl alternatives (cationic polyacrylamide, natural cationic polymer, dicyandiamide resin).

We present the nature of 50 hard X-ray emitting objects unveiled through an optical spectroscopy campaign performed at seven telescopes in the northern and southern hemispheres. These objects were detected with the Burst Alert Telescope (BAT) instrument onboard the Swift satellite and listed as of unidentified nature in the 54-month Palermo BAT catalogue. In detail, 45 sources in our sample are identified as active galactic nuclei of which, 27 are classified as type 1 (with broad and narrow emission lines) and 18 are classified as type 2 (with only narrow emission lines). Among the broad-line emission objects, one is a type 1 high-redshift quasi-stellar object, and among the narrow-line emission objects, one is a starburst galaxy, one is a X-ray bright optically normal galaxy, and one is a low ionization nuclear emission line region. We report 30 new redshift measurements, 13 confirmations and 2 more accurate redshift values. The remaining five objects are galactic sources: three are Cataclismic Variables, one is a X-ray Binary probably with a low mass secondary star, and one is an active star. Based on observations obtained from the following observatories: Cerro Tololo Interamerican Observatory (Chile); Astronomical Observatory of Bologna in Loiano (Italy); Observatorio Astronómico Nacional (San Pedro Mártir, Mexico); Radcliffe telescope of the South African Astronomical Observatory (Sutherland, South Africa); Sloan Digital Sky Survey; Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias (Canary Islands, Spain) and New Technology Telescope (NTT) of La Silla Observatory, Chile.

Narrow-line Seyfert 1 (NLSy1) galaxies are a peculiar class of type 1 active galactic nuclei (broad-line Seyfert 1 galaxies, hereinafter BLSy1). The X-ray properties of individual objects belonging to this class are often extreme and associated with accretion at high Eddington ratios. Here, we present a study on a sample of 14 NLSy1 galaxies selected at hard X-rays (>20 keV) from the fourth INTEGRAL/IBIS catalogue. The 20–100 keV IBIS spectra show hard-X-ray photon indices flatly distributed (Γ20−100 keV ranging from ∼1.3 to ∼3.6) with an average value of 〈Γ20−100 keV〉= 2.3 ± 0.7, compatible with a sample of hard-X-ray BLSy1 average slopes. Instead, NLSy1 galaxies show steeper spectral indices with respect to BLSy1 galaxies when broad-band spectra are considered. Indeed, we combine XMM–Newton and Swift/XRT with INTEGRAL/IBIS data sets to obtain a wide energy spectral coverage (0.3–100 keV). A constraint on the high energy cut-off and on the reflection component is achieved only in one source, SWIFT J2127.4+5654 (Ecut-off∼ 50 keV, R= 1.0+0.5− 0.4). Hard-X-ray-selected NLSy1 galaxies do not display particularly strong soft excess emission, while absorption fully or partially covering the continuum is often measured as well as Fe line emission features. Variability is a common trait in this sample, both at X-rays and at hard X-rays. The fraction of NLSy1 galaxies in the hard-X-ray sky is likely to be ∼15 per cent, in agreement with estimates derived in optically selected NLSy1 samples. We confirm the association of NLSy1 galaxies with small black hole masses with a peak at 107 M⊙ in the distribution; however, hard-X-ray NLSy1 galaxies seem to occupy the lower tail of the Eddington ratio distribution of classical NLSy1 galaxies.

We present spectral and temporal results from INTEGRAL long-term monitoring of the unidentified X-ray source IGR J17354 3255. We show that it is a weak persistent hard X-ray source spending a major fraction of the time in an out-of-outburst state with average 18–60 keV X-ray flux of � 1.1 mCrab, occasionally interspersed with fast X-ray flares (duration from a few hours to a few days) with a dynamic range as high as � 200. From archival Swift/XRT observations, we also show that the dynamic range from non-detection to highest level of measured X-ray activity is >300. Our IBIS timing analysis strongly confirms the � 8.4 days orbital period previously detected with Swift/BAT, in addition we show that the shape of the orbital profile is rather smooth and appears to be dominated by low level X-ray emission rather than by bright outbursts, the measured degree of outburst recurrence is � 25%. The spectral and temporal characteristics of IGR J17354 3255 are highly indicative of a Supergiant High Mass X-ray Binary nature (SGXB). However, our inferred dynamic ranges both at soft and hard X-rays are significantly greater than those of classical SGXB systems, but instead are typical of intermediate Supergiant Fast X-ray Transient (SFXTs). Finally, we note for the first time that the observed fast flaring X-ray behaviour of IGR J17354 3255 is very similar to that detected with AGILE from the spatially associated MeV source AGL J1734 3310, suggesting a possible physical link between the two objects.

Since its launch on October 2002, the INTEGRAL satellite has revolutionized our knowledge of the hard X-ray sky thanks to its unprecedented imaging capabilities and source detection positional accuracy above 20 keV. Nevertheless, many of the newly-detected sources in the INTEGRAL sky surveys are of unknown nature. However, the combined use of available information at longer wavelengths (mainly soft X-rays and radio) and of optical spectroscopy on the putative counterparts of these new hard X-ray objects allows pinpointing their exact nature. Continuing our long-standing program running since 2004 (and with which we identified more than 100 INTEGRAL objects) here we report the classification, through optical spectroscopy, of 25 unidentified high-energy sources mostly belonging to the recently published 4th IBIS survey., Comment: 6 pages, 1 figure, 1 table; accepted for publication in the Proceedings of HEPRO-II Conference (International Journal of Modern Physics D, in press; eds. G.E. Romero, F.A. Aharonian and J.M. Paredes)

The most recent IBIS/ISGRI survey, i.e. the fourth one, lists 723 hard X-ray sources, many still unidentified, i.e. lacking an X-ray counterpart or simply not studied at lower energies, i.e. below 10 keV. In order to overcome this lack of X-ray information, we cross-correlated the list of IBIS sources included in the fourth IBIS catalogue with the Swift/X-ray Telescope (XRT) data archive, finding a sample of 20 objects, not yet reported in the literature, for which XRT data could help in the search for the X-ray and hence optical counterpart and/or, for the first time, in the study of the source spectral and variability properties below 10 keV. 16 of these objects are new INTEGRAL detections, while four were already listed in the third survey but not yet observed in X-rays. Four objects (IGR J00465-4005, LEDA 96373, IGR J1248.2-5828 and IGR J13107-5626) are confirmed or likely absorbed active galaxies, while two (IGR J14080-3023 and 1RXS J213944.3+595016) are unabsorbed active galactic nuclei (AGN). We also find three peculiar extragalactic objects, NGC 4728 being a narrow-line Seyfert galaxy, MCG+04-26―006 a type 2 Low Ionization Nuclear Emission Region and PKS 1143-693 probably a quasi-stellar object; furthermore, our results indicate that IGR J08262+4051 and IGR J22234-4116 are candidate AGN, which require further optical spectroscopic follow-up observations to be fully classified. Only in the case of 1RXS J080114.6―462324, we are confident that the source is a Galactic object. For IGR J10447-6027, IGR J12123―5802 and IGR J20569+4940, we pinpoint one X-ray counterpart, although its nature could not be assessed despite spectral and sometimes variability information being obtained. Clearly, we need to perform optical follow-up observations in order to firmly assess their nature. There are five objects for which we find no obvious X-ray counterpart (IGR J07506-1547 and IGR J17008―6425) or even no detection (IGR J17331-2406, IGR J18134-1636 and IGR J18175―1530); apart from IGR J18134-1636, all these sources are found to be variable in the IBIS energy band, therefore it is difficult to catch them even in X-rays.

We report on the identification of the gamma-ray source 0FGL J20001.0+4352 listed in the Fermi bright source catalogue. This object, which has an observed 1-100 GeV flux of (7.8 +/- 1.2) x 10^{-9} ph cm^{-2} s^{-1} and is located close to the Galactic plane, is not associated with any previously known high energy source. We use archival XMM-Newton and Swift/XRT data to localise with arcsec accuracy the X-ray counterpart of this GeV emitter and to characterise its X-ray properties: the source is bright (the 0.2-12 keV flux is 1.9 x 10^{-12} erg cm^{-2} s^{-1}), variable (by a factor of ~2) and with a steep power law spectrum (Gamma = 2.7). It coincides with a radio bright (~200 mJy at 8.4 GHz) and flat spectrum object (MG4 J200112+4352 in NED). Broad-band optical photometry of this source suggests variability also in this waveband, while a spectroscopic follow-up observation provides the first source classification as a BL Lac object. The source SED, as well as the overall characteristics and optical classification, point to a high frequency peaked blazar identification for 0FGL J2001.0+4352., 5 pages, 2 tables, 5 figures. Accepted for publication in MNRAS Letters

The analysis of the third INTEGRAL/IBIS survey has revealed several new cataclysmic variables, most of which turned out to be intermediate polars, thus confirming that these objects are strong emitters in hard X-rays. Here we present high energy spectra of all 22 cataclysmic variables detected in the 3rd IBIS survey and provide the first average spectrum over the 20-100 keV band for this class. Our analysis indicates that the best-fit model is a thermal bremsstrahlung with an average temperature of ~22 keV. Recently, eleven (ten intermediate polars and one polar) of these systems have been followed-up by Swift/XRT (operating in the 0.3-10 keV energy band), thus allowing us to investigate their spectral behaviour over the range ~0.3-100 keV. Thanks to this wide energy coverage, it was possible for these sources to simultaneously measure the soft and hard components and estimate their temperatures. The soft emission, thought to originate in the irradiated poles of the white dwarf atmosphere, is well described by a blackbody model with temperatures in the range ~60-120 eV. The hard emission, which is supposed to be originated from optically thin plasma in the post-shock region above the magnetic poles, is indeed well modelled with a bremsstrahlung model with temperatures in the range ~16-33 keV, similar to the values obtained from the INTEGRAL data alone. In several cases we also find the presence of a complex absorber: one totally (with NH ~(0.4-28) x 10^{21} cm^{-2}) and one partially (with NH ~(0.7-9) x 10^{23} cm^{-2}) covering the source. Only in four cases (V709 Cas, GK Per, IGR J06253+7334 and IGR J17303-0601), we find evidence for the presence of an iron line at 6.4 keV. We discuss our findings in the light of the systems parameters and cataclysmic variables/intermediate polars modelling scenario., Comment: 16 pages, including 6 figures and 5 tables. Accepted for publication in MNRAS

Narrow Line Seyfert 1 galaxies (NLS1) are very interesting objects which display peculiar properties when compared to their broad line analogues (BLS1). Although well studied in many wavebands, their behaviour at >10 keV is poorly studied and yet important to discriminate between models invoked to explain the complexity observed in the X-ray band. Here we present for the first time high energy observations (17-100 keV) of five NLS1 galaxies (3 bona fide and 2 candidates) detected by INTEGRAL/IBIS and provide for all of them a broad band spectral analysis using data obtained by Swift/XRT below 10 keV. The combined INTEGRAL spectrum is found to be steeper (Gamma=2.6 +/- 0.3) than those of classical Seyfert 1 objects. This is due to a high energy cutoff, which is required in some individual fits as in the average broad band spectrum. The location of this high energy cutoff is at lower energies (E < 60 keV) than typically seen in classical type 1 AGNs; a reflection component may also be present but its value (R < 0.8) is compatible with those seen in standard Seyfert 1s. We do not detect a soft excess in individual objects but only in their cumulative spectrum. Our results suggest a lower plasma temperature for the accreting plasma which combined to the high accretion rates (close to the Eddington rate) point to different nuclear conditions in broad and narrow line Seyfert 1 galaxies, likely related to different evolutionary stages., 7 pages, 5 figures; corrected text in section 3, accepted for publication in MNRAS

Context: IGR J16479-4514 is a fast X-ray transient known to display flares lasting typically a few hours. Recently, its counterpart has been identified with a supergiant star, therefore the source can be classified as member of the newly discovered class of Supergiant Fast X-ray Transients (SFXTs), specifically it is the one with the highest duty cycle. Aims: to characterize the quiescent X-ray behaviour of the source and to compare its broad band spectrum to that during fast X-ray flares. Methods: we performed an analysis of IBIS and JEM-X data with OSA 5.1 as well as an analysis of archival Swift/XRT data. Results: we present results from a long term monitoring of IGR J16479-4514 with detailed spectral and timing informations on 19 bright fast X-ray flares, 10 of which newly discovered. We also report for the first time results on the quiescent X-ray emission; the typical luminosity value (about 10^34 erg s^-1) is about 2 orders of magnitude greater than that typical of SFXTs while its broad band X-ray spectrum has a shape very similar to that during fast X-ray transient activity, i.e. a rather steep power law with Gamma=2.6. Conclusions: IGR J16479$-$4514 is characterized by a quiescent X-ray luminosity higher than that typical of other known SFXTs but lower than persistent emission from classical SGXBs. We suggest that such source is a kind of transition object between these two systems, supporting the idea that there is a continuum of behaviours between the class of SFXTs and that of classical persistent SGXBs., Comment: 5 pages, 4 figures, accepted for publication in A&A

IGR J16493-4348 was one of the first new sources to be detected by the INTEGRAL gamma-ray telescope in the 18-100 keV energy band. Based upon spatial coincidence the source was originally associated with the free radio pulsar PSR J1649-4349. Presented here are the results of 2.8 Ms of observations made by the INTEGRAL mission and a 5.6 ks observation with the Swift X-ray Telescope. Spectral analysis indicates that the source is best modeled by an absorbed power law with a high energy cut-off at E$_{cut}$~15 keV and a hydrogen absorbing column of NH=5.4$^{+1.3}_{-1}$ x 10$^{22}$ cm$^{-2}$. Analysis of the light curves indicates that the source is a weak, persistent gamma-ray emitter showing indications of variability in the 2-9 and 22-100 keV bands. The average source flux is ~1.1 x 10^{-10} erg cm$^{-2}$ s$^{-1}$ in the 1-100 keV energy band. No coherent timing signal is identified at any timescale in the INTEGRAL or Swift data. The refined source location and positional uncertainty of IGR J16493-4348 places PSR J1649-4349 outside of the 90% error circle. We conclude that IGR J16493-4348 is not associated with PSR J1649-4349. Combining the INTEGRAL observations with Swift/XRT data and information gathered by RXTE and Chandra we suggest that IGR J16493-4348 is an X-ray binary; and that the source characteristics favour a high mass X-ray binary although an LMXB nature cannot be ruled out.

We present spectral measurements made in the soft (20-100 keV) gamma-ray band of the region containing the composite supernova remnant G11.2-0.3 and its associated pulsar PSR J1811-1925. Analysis of INTEGRAL/IBIS data allows characterisation of the system above 10 keV. The IBIS spectrum is best fitted by a power law having photon index of 1.8^{+0.4}_{-0.3} and a 20-100 keV flux of 1.5E{-11} erg/cm^2/s. Analysis of archival Chandra data over different energy bands rules out the supernova shell as the site of the soft gamma-ray emission while broad band (1-200 keV) spectral analysis strongly indicates that the INTEGRAL/IBIS photons originate in the central zone of the system which contains both the pulsar and its nebula. The composite X-ray and soft gamma-ray spectrum indicates that the pulsar provides around half of the emission seen in the soft gamma-ray domain; its spectrum is hard with no sign of a cut off up to at least 80 keV. The other half of the emission above 10 keV comes from the PWN; with a power law slope of 1.7 its spectrum is softer than that of the pulsar. From the IBIS/ISGRI mosaics we are able to derive 2 sigma upper limits for the 20-100 keV flux from the location of the nearby TeV source HESS J1809-193 to be 4.8E{-12} erg/cm^2/s. We have also examined the likelihood of an association between PSR J1811-1925 and HESS J1809-193. Although PSR J1811-1925 is the most energetic pulsar in the region, the only one detected above 10 keV and thus a possible source of energy to fuel the TeV fluxes, there is no morphological evidence to support this pairing, making it an unlikely counterpart., 6 pages, 2 figures, accepted for publication in MNRAS

We report on the identification of a new soft gamma ray source, namely IGR J22517+2218, detected with IBIS/INTEGRAL. The source, which has an observed 20-100 keV flux of ~4 x10^-11 erg cm-2 s-1, is spatially coincident with MG3 J225155+2217, a quasar at z=3.668. The Swift/XRT 0.5-10 keV continuum is flat (Gamma=1.5) with evidence for a spectral curvature below 1-2 keV either due to intrinsic absorption (NH=3 +/- 2 x 10^22 cm-2) or to a change in slope (Delta Gamma= 0.5). X-ray observations indicate flux variability over a 6 days period which is further supported by a flux mismatch between Swift and INTEGRAL spectra. IGR J22517+2218 is radio loud and has a flat radio spectrum; optically it is a broad line emitting quasar with the atypical property of hosting a narrow line absorption system. The Source Spectral Energy Distribution is unusual compared to blazars of similar type: either it has the synchrotron peak in the X/gamma-ray band (i.e. much higher than generally observed) or the Compton peak in the MeV range (i.e. lower than typically measured). IGR J22517+2218=MG3 J225155+2217 is the second most distant blazar detected above 20 keV and a gamma-ray lighthouse shining from the edge of our Universe., Comment: 4 pages, 4 figures, Accepted for publication in Astrophysical Journal Letters

We here report on the multiwavelength study which led us to the identification of X-ray source IGR J16194-2810 as a new Symbiotic X-ray Binary (SyXB), that is, a rare type of Low Mass X-ray Binary (LMXB) composed of a M-type giant and a compact object. Using the accurate X-ray position allowed by Swift/XRT data, we pinpointed the optical counterpart, a M2 III star. Besides, the combined use of the spectral information afforded by XRT and INTEGRAL/IBIS shows that the 0.5-200 keV spectrum of this source can be described with an absorbed Comptonization model, usually found in LMXBs and, in particular, in SyXBs. No long-term (days to months) periodicities are detected in the IBIS data. The time coverage afforded by XRT reveals shot-noise variability typical of accreting Galactic X-ray sources, but is not good enough to explore the presence of X-ray short-term (seconds to hours) oscillations in detail. By using the above information, we infer important parameters for this source such as its distance (about 3.7 kpc) and X-ray luminosity (about 1.4e35 erg/s in the 0.5-200 keV band), and we give a description for this system (typical of SyXBs) in which a compact object (possibly a neutron star) accretes from the wind of its M-type giant companion. We also draw some comparisons between IGR J16194-2810 and other sources belonging to this subclass, finding that this object resembles SyXBs 4U 1700+24 and 4U 1954+31., 9 pages, 4 figures, 3 tables. Accepted for publication on Astronomy & Astrophysics, main journal. Slight changes to match the proof-corrected version: Pdot/P for 4U 1954+31 (in Table 3) corrected; acknowledgements expanded; references updated

IGR J18483-0311 is a poorly known transient hard X-ray source discovered by INTEGRAL during observations of the Galactic Center region performed between 23--28 April 2003. Aims: To detect new outbursts from IGR J18483-0311 using INTEGRAL and archival Swift XRT observations and finally to characterize the nature of this source using the optical/near-infrared (NIR) information available through catalogue searches. Results: We report on 5 newly discovered outbursts from IGR J18483-0311 detected by INTEGRAL.For two of them it was possible to constrain a duration of the order of a few days. The strongest outburst reached a peak flux of 120 mCrab (20--100 keV): its broad band JEM--X/ISGRI spectrum (3--50 keV) is best fitted by an absorbed cutoff power law with photon index=1.4+/-0.3, cutoff energy of ~22 keV and Nh ~9x10^22 cm^-2. Timing analysis of INTEGRAL data allowed us to identify periodicities of 18.52 days and 21.0526 seconds which are likely the orbital period of the system and the spin period of the X-ray pulsar respectively. Swift XRT observations of IGR J18483$-$0311 provided a very accurate source position which strongly indicates a highly reddened star in the USNO--B1.0 and 2MASS catalogues as its possible optical/NIR counterpart. Conclusions: The X-ray spectral shape, the periods of 18.52 days and 21.0526 seconds, the high intrinsic absorption, the location in the direction of the Scutum spiral arm and the highly reddened optical object as possible counterpart, all favour the hypothesis that IGR J18483-0311 is a HMXB with a neutron star as compact companion. The system is most likely a Be X-ray binary, but a Supergiant Fast X-ray Transient nature can not be entirely excluded., accepted for publication in A&A, 10 pages, 17 figures, 4 tables

Optical spectroscopic identification of the nature of 21 unidentified southern hard X-ray objects is reported here in the framework of our campaign aimed at determining the nature of newly-discovered and/or unidentified sources detected by INTEGRAL. Our results show that 5 of these objects are magnetic Cataclysmic Variables (CVs), 4 are High-Mass X-ray Binaries (HMXBs; one of which is in the Large Magellanic Cloud) and 12 are Active Galactic Nuclei (AGNs). When feasible, the main physical parameters for these hard X-ray sources are also computed using the multiwavelength information available in the literature. These identifications further underscore the importance of INTEGRAL in the study of the hard X-ray spectrum of AGNs, HMXBs and CVs, and the usefulness of a strategy of catalogues cross-correlation plus optical spectroscopy to securely pinpoint the actual nature of the X-ray sources detected with INTEGRAL., 14 pages, 7 figures, 6 tables, accepted for publication on A&A, main journal. Figures 1 and 2 and Table 1 will only appear on the on-line version of the paper

Anisakidosis is a parasitic infection caused by the ingestion of row or uncooked fish, containing larval nematodes from the Anisakidae family. Intestinal anisakidosis represents about 4% of all cases, the majority being localized in the small bowel, with rare colonic involvement. Here we present an infrequent case of chronic anisakidosis, presenting with intestinal intussusception.A 52 years old woman, chronically treated with immunosuppressants, presented to our Institution with acute abdominal pain and vomiting, due to colocolic intussusception. Colonoscopy successfully reduced the intussusception and revealed the presence of a voluminous colonic submucosal mass, near the hepatic flexure. Therefore, the patient underwent laparoscopic right hemicolectomy. The diagnosis of anisakidosis was made when the histological examination of the surgical specimen revealed the infestation of the intestinal wall by a nematode of the Anisakidae family, with an intense erosive-inflammatory adjacent reaction.

We report the results from our analysis of a large set of archival data acquired with the X-ray telescope (XRT) onboard Swift, covering the sky region surrounding objects from the first Fermi Large Area Telescope (LAT) catalogue of high-energy sources (1FHL), which still lack an association. Of the 23 regions analysed, ten did not show any evidence of X-ray emission, but 13 were characterised by the presence of one or more objects emitting in the 0.3-10 keV band. Only in a couple of cases is the X-ray counterpart located outside the Fermi positional uncertainty, while in all other cases the associations found are compatible with the high-energy error ellipses. All counterparts we found have been studied in detail by means of a multi-waveband approach to evaluate their nature or class; in most cases, we have been able to propose a likely or possible association except for one Fermi source whose nature remains doubtful at the moment. The majority of the likely associations are extragalactic in nature, most probably blazars of the BL Lac type., Comment: 13 pages, 5 figures, 4 tables. Accepted for publication in A&A

In this work we present the observation of the Mkn 463 field performed with the MECS instrument on-board BeppoSAX in the 1.8-10.5 keV band. The Mkn 463 field is an example of an extragalactic field crowded with absorbed X-ray sources: apart from the Seyfert 2 galaxy Mkn 463 and the well known QSO PG 1352+183 (the only object showing no absorption), two other objects are detected with a column density in excess to the galactic value. The first 1SAX J1353.9+1820 is a red QSO from the BeppoSAX High Energy Large Area Survey (HELLAS). The second 1SAX J1355.4+1815 is optically unidentified, but its X-ray spectral characteristics indicate that it too is an AGN hidden behind a large column density.

We investigate the role of the coronal mass ejections (CMEs) (by using soft X ray solar emission as proxy data) in producing the nonrecurrent geomagnetic storms in the period 1969-1974. The linkage between these phenomena is confirmed: however, it turns out that CMEs associated with chromospheric flares, accompanied by type 4 radio emission, are the most effective in perturbing the geomagnetic field.

This paper summarizes the development of a successful project, LAUE, supported by the Italian Space Agency (ASI) and devoted to the development of long focal length (up to 100 m) Laue lenses for hard X--/soft gamma--ray astronomy (80-600 keV). The apparatus is ready and the assembling of a prototype lens petal is ongoing. The great achievement of this project is the use of bent crystals. From measurements obtained on single crystals and from simulations, we have estimated the expected Point Spread Function and thus the sensitivity of a lens made of petals. The expected sensitivity is a few $\times10^{-8}$ photons cm$^{-2}$ s$^{-1}$ keV$^{-1}$. We discuss a number of open astrophysical questions that can settled with such an instrument aboard a free-flying satellite., 17 pages, 18 figures, published in Proceedings of the SPIE, Volume 8861, id. 886106 17 pp. (2013)

The aim of this paper is to study the stellar population of galaxies hosting an active galactic nucleus (AGN). We studied a sub-sample of hard X-ray emitting AGNs from the INTEGRAL and Swift catalogs which were previously identified and characterized through optical spectroscopy. Our analysis provides complementary information, namely age and metallicity, which is necessary to complete the panoramic view of such interesting objects. We selected hard X-ray emitting objects identified as AGNs by checking their optical spectra in search for absorption lines suitable for the stellar population analysis. We obtained a final sample consisting of 20 objects with redshift lower than 0.3. We used the full-spectrum fitting method and, in particular, the penalized pixel one applying the PPXF code. After masking all the regions affected by emission lines, we fitted the spectra with the MILES single stellar population templates and we derived mass-weighted ages and metallicities. Most of the objects in our sample show an old stellar population, but three of them are characterized by a bimodal distribution with a non negligible contribution from young stars. The values of the mass-weighted metallicity span a large range of metallicity with most of them slightly above the solar value. No relations between the stellar population properties and the morphological ones have been found., 10 pages, 8 postscript figures and 3 tables. A&A in press

Within the framework of our program (running since 2004) of identification of hard X-ray INTEGRAL sources through optical spectroscopy, we present the results concerning the nature of 33 high-energy objects. The data were acquired with the use of six telescopes of different sizes and from one on-line archive. The results indicate that the majority of these objects (23 out of 33) are active galactic nuclei (AGNs), whereas 10 are sources in the local Universe with eight of which in the Galaxy and two in the Small Magellanic Cloud (SMC). Among the identified AGNs, 13 are of Type 1 (i.e., with broad emission lines), eight are of Type 2 (with narrow emissions only), and two are X-ray bright, optically normal galaxies with no apparent nuclear activity in the optical. Six of these AGNs lie at high redshift (z > 0.5). Concerning local objects, we found that five of them are Galactic cataclysmic variables, three are high-mass X-ray binaries (two of which lying in the SMC), one is a low-mass X-ray binary, and one is classified as a flare star that is likely of RS CVn type. The main optical properties and inferred physical characteristics of these sources are presented and discussed., 22 pages, 13 figures, 9 tables, accepted for publication on Astronomy and Astrophysics, main journal. Redshift uncertainty of IGR J16388+3557 corrected in note of Table 3; references updated

We report on the identification of a new soft gamma-ray source, namely IGR J20159+3713/SWIFT J2015.9+3715, first detected by INTEGRAL/IBIS and then confirmed by Swift/BAT. The source, which has an observed 20-100 keV flux in the range (0.7-1.4) x 10^(-11) erg cm^(-2) s^(-1), encloses a Fermi variable source (2FGL J2015.6+3709) and is spatially close to a TeV emitter (VER J2016+372). Thanks to X-ray follow-up observations performed with the X-ray telescope on board Swift, we have been able to identify the new IBIS/BAT detection with the combined emission of the blazar B2013+370 and the cataclysmic variable RX J2015.6+3711. Both objects show variability in X-rays, with the CV being the most variable of the two. At high energies (above 20 keV) the emission is likely dominated by B2013+370, but the contribution from RX J2015.6+3711 is not negligible. The blazar emits up to GeV frequencies where it is seen by Fermi, while the cataclysmic variable has a bremsstrahlung temperature which is too low to provide any contribution at these high energies. These findings also indicate that the INTEGRAL/Swift source is not associated with the TeV emission, which is most likely due to the supernova remnant (SNR)/pulsar wind nebula (PWN) CTB 87., Comment: 6 pages, 4 figures, 2 tables. Accepted for publication on A&A, main journal

We report on a broad-band X-ray study (0.5-60 keV) of the poorly known candidate Supergiant Fast X-ray Transient (SFXT) IGR J18462-0223, and on optical and near-infrared (NIR) followup observations of field objects. The out-of-outburst X-ray state has been investigated for the first time with archival INTEGRAL/IBIS, ASCA, Chandra and Swift/XRT observations. This allowed us to place stringent 3 sigma upper limits on the soft (0.5-10 keV) and hard (18-60 keV) X-ray emission of 2.9x10^-13 erg cm^-2 s^-1 and 8x10^-12 erg cm^-2 s^-1, respectively; the source was also detected during an intermediate soft X-ray state with flux equal to 1.6x10^-11 erg cm^-2 s^-1 (0.5-10 keV). In addition, we report on the INTEGRAL/IBIS discovery of three fast hard X-ray flares (18-60 keV) having a duration in the range 1-12 hours: the flaring behavior was also investigated in soft X-rays (3-10 keV) with archival INTEGRAL/JEM-X observations. The duty cycle (1.2%) and the dynamic ranges (> 1,380 and > 190 in the energy bands 0.5-10 keV and 18-60 keV, respectively) were measured for the first time. Archival UKIDSS JHK NIR data, together with our deep R-band imaging of the field, unveiled a single, very red object inside the intersection of the Swift/XRT and XMM-Newton error circles: this source has optical/NIR photometric properties compatible with a very heavily absorbed blue supergiant located at about 11 kpc, thus being a strong candidate counterpart for IGR J18462-0223. NIR spectroscopy is advised to confirm the association. Finally, a hint of a possible orbital period was found at about 2.13 days. If confirmed by further studies, this would make IGR J18462-0223 the SFXT with the shortest orbital period among the currently known systems., accepted for publication in A&A, 9 pages, 7 figures, 2 tables

Context. Based on their overwhelming dominance among associated Fermi γ-ray catalogue sources, it is expected that a large fraction of the unidentified Fermi objects are blazars. Through crossmatching between the positions of unidentified γ-ray sources from the First Fermi Catalog of γ-ray sources emitting above 10 GeV (1FHL) and the ROSAT and Swift/XRT catalogues of X-ray objects and between pointed XRT observations, a sample of 36 potential associations was found in previous works with less than 15 arcsec of positional offset. One-third of them have recently been classified; the remainder, though believed to belong to the blazar class, still lack spectroscopic classifications. Aims. We study the optical spectrum of the putative counterparts of these unidentified gamma-ray sources in order to find their redshifts and to determine their nature and main spectral characteristics. Methods. An observational campaign was carried out on the putative counterparts of 13 1FHL sources using medium-resolution optical spectroscopy from the Osservatorio Astronomico di Bologna in Loiano, Italy; the Telescopio Nazionale Galileo and the Nordic Optical Telescope, both in the Canary Islands, Spain; and the Observatorio Astronómico Nacional San Pedro Mártir in Baja California, Mexico. Results. We were able to classify 14 new objects based on their continuum shapes and spectral features. Conclusions. Twelve new blazars were found, along with one new quasar and one new narrow line Seyfert 1 (NLS1) to be potentially associated with the 1FHL sources of our sample. Redshifts or lower limits were obtained when possible alongside central black hole mass and luminosity estimates for the NLS1 and the quasar., Facultad de Ciencias Astronómicas y Geofísicas, Instituto de Astrofísica de La Plata

Using data collected with the BeppoSAX, INTEGRAL and Swift satellites, we report and discuss the results of a study on the X-ray emission properties of the X-ray source 1ES 1210-646, recently classified as a high-mass X-ray binary through optical spectroscopy. This is the first in-depth analysis of the X-ray spectral characteristics of this source. We found that the flux of 1ES 1210-646 varies by a factor of about 3 on a timescale of hundreds of seconds and by a factor of at least 10 among observations acquired over a time span of several months. The X-ray spectrum of 1ES 1210-646 is described using a simple powerlaw shape or, in the case of INTEGRAL data, with a blackbody plus powerlaw model. Spectral variability is found in connection with different flux levels of the source. A strong and transient iron emission line with an energy of about 6.7 keV and an equivalent width of about 1.6 keV is detected when the source is found at an intermediate flux level. The line strength seems to be tied to the orbital motion of the accreting object, as this feature is only apparent at the periastron. Although the X-ray spectral description we find for the 1ES 1210-646 emission is quite atypical for a high-mass X-ray binary, the multiwavelegth information available for this object leads us to confirm this classification. The results presented here allow us instead to definitely rule out the possibility that 1ES 1210-646 is a (magnetic) cataclysmic variable as proposed previously and, in a broader sense, a white dwarf nature for the accretor is disfavoured. X-ray spectroscopic data actually suggest a neutron star with a low magnetic field as the accreting object in this system., 10 pages, 5 figures, 3 tables, accepted for publication on Astronomy and Astrophysics, main journal

We have constructed a new sample of magnetic cataclysmic variables (mCVs) by cross‐correlating candidate sources detected in INTEGRAL/IBIS observations against catalogues of known CVs and included mCVs observed with either Swift/BAT or SUZAKU/HXD. Here we review the properties arising from this hard X‐ray selected sample and find that most hard X‐ray detected mCVs have Pspin/Porb

Hard X-ray surveys have proven remarkably efficient in detecting intermediate polars and asynchronous polars, two of the rarest type of cataclysmic variable (CV). Here we present a global study of hard X-ray selected intermediate polars and asynchronous polars, focusing particularly on the link between hard X-ray properties and spin/orbital periods. To this end, we first construct a new sample of these objects by cross-correlating candidate sources detected in INTEGRAL/IBIS observations against catalogues of known CVs. We find 23 cataclysmic variable matches, and also present an additional 9 (of which 3 are definite) likely magnetic cataclysmic variables (mCVs) identified by others through optical follow-ups of IBIS detections. We also include in our analysis hard X-ray observations from Swift/BAT and SUZAKU/HXD in order to make our study more complete. We find that most hard X-ray detected mCVs have P_{spin}/P_{orb}, 14 pages, 8 figures and 3 tables. Accepted for publication in MNRAS

Through an optical campaign performed at 5 telescopes located in the northern and the southern hemispheres, plus archival data from two on line sky surveys, we have obtained optical spectroscopy for 17 counterparts of suspected or poorly studied hard X-ray emitting active galactic nuclei (AGNs) detected with Swift/BAT in order to determine or better classify their nature. We find that 7 sources of our sample are Type 1 AGNs, 9 are Type 2 AGNs, and 1 object is an X-ray bright optically normal galaxy; the redshifts of these objects lie in a range between 0.012 and 0.286. For all these sources, X-ray data analysis was also performed to estimate their absorption column and to search for possible Compton thick candidates. Among our type 2 objects, we did not find any clear Compton thick AGN, but at least 6 out of 9 of them are highly absorbed (N_H > 10^23 cm^-2), while one does not require intrinsic absorption; i.e., it appears to be a naked Seyfert 2 galaxy., 15 pages, 7 figures, 4 tables. Accepted for publication on Astronomy & Astrophysics, main journal. The name of the source Swift J0519.5-3140 corrected with Swift J0501.9-3239