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Introduction & Objective: Melasma is an acquired hypermelanosis disease and can cause superficial problems in women if left untreated. The objective of this study was to compare the efficacy of 2% hydroquinone and Melfade in the treatment of Melasma. Materials & Methods: This is a randomized clinical trial study conducted at Kurdistan University of Medical Sciences in 2008. Sixty two women with Melasma disease were recruited and randomly assigned to two groups. Two percent hydroquinone was prescribed for the first group (n=31) and Melfade for the second group. After 12 weeks of daily drug consumption by the patients, they were examined by a dermatologist for assessment of recovery. The collected data was analyzed by the SPSS software. Results: Response to treatment with hydroquinone and Melfade- was the same and no significant differences were found between the two groups. (P>0.05) onclusion: Results of this study demonstrated that topical Melfade is as effective as 2% hydrquinone in treatment of Melasma, Therefore it can be considered as an alternative drug in the treatment of Melasma.

Introduction & Objective: Aphthous stomamtitis is characterized by single or multiple painful recurrent lesions in oral mucosa. Lesions can relapse in some patients for several years. Therefore treatment of such cases seems necessary. The aim of this study was to compare the therapeutic effect of topical Myrtus communis (myrtle) solution with topical triamcinolone (Adcortyle) in the treatment of minor apotheosis. Materials & Methods: This clinical-trial study was conducted at Kurdistan University of Medical Sciences in 2009. 100 patients were randomly assigned into 2 groups. The 1st group received topical myrtle solution. The 2nd group received topical trimcinolone (Adcortyle). After one week, patients' declaration about time of the recovery of the pain and deterioration of oral lesion was recorded. The gathered data was then analyzed using the SPSS statistical software using t-test and chi-square. Results: After treatment, both groups showed response to topical medications with no significant difference between them (p>0.05). Conclusion: results of this study showed that topical myrtle solution is effective in the treatment of minor aphthous stomatitis and its therapeutic effect is comparable with topical triamcinolone (Adcortyle).

ABSTRACT: Introduction & Objective: Acne vulgaris is a common skin disease which affects a large number of adolescents and adults at some time in their life. Several drugs have been used for the treatment of acne vulgaris and recently systemic azithromycin has been tried for its treatment. The aim of this study was to compare the therapeutic efficacy of azithromycin vs. tetracycline in acne vulgaris. Materials & Methods: The present study was a randomized investigator-blind clinical trial, carried out at the outpatient department of Besat Hospital of Sanandaj in 2008. 82 patients were allocated randomly into two groups. Azithromycin 500 mg for 3 consecutive days per week for the first month, then 250 mg/ every other day was prescribed for the first group .The second group received tetracycline 250 mg/6h .The treatments continued for 12 weeks. The therapeutic efficacy of these drugs was assessed on the basis of lesion counting. Data were introduced into SPSS 11.5 software and analyzed by means of independent t- test, Mann-Whitney and chi-square test. Results: The mean number of lesions was not statistically different before treatment in the two groups. There was statistically a significant difference in the mean number of inflammatory papular lesions on the face and back after treatment (p