Search

Your search keyword '"R Van de Water"' showing total 322 results
Start Over Author "R Van de Water"
322 results on '"R Van de Water"'

1. FLAG Review 2021

Author

Y. Aoki, T. Blum, G. Colangelo, S. Collins, M. Della Morte, P. Dimopoulos, S. Dürr, X. Feng, H. Fukaya, M. Golterman, Steven Gottlieb, R. Gupta, S. Hashimoto, U. M. Heller, G. Herdoiza, P. Hernandez, R. Horsley, A. Jüttner, T. Kaneko, E. Lunghi, S. Meinel, C. Monahan, A. Nicholson, T. Onogi, C. Pena, P. Petreczky, A. Portelli, A. Ramos, S. R. Sharpe, J. N. Simone, S. Simula, S. Sint, R. Sommer, N. Tantalo, R. Van de Water, U. Wenger, H. Wittig, and Flavour Lattice Averaging Group (FLAG)

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We review lattice results related to pion, kaon, D-meson, B-meson, and nucleon physics with the aim of making them easily accessible to the nuclear and particle physics communities. More specifically, we report on the determination of the light-quark masses, the form factor $$f_+(0)$$ f + ( 0 ) arising in the semileptonic $$K \rightarrow \pi $$ K → π transition at zero momentum transfer, as well as the decay constant ratio $$f_K/f_\pi $$ f K / f π and its consequences for the CKM matrix elements $$V_{us}$$ V us and $$V_{ud}$$ V ud . Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of $$SU(2)_L\times SU(2)_R$$ S U ( 2 ) L × S U ( 2 ) R and $$SU(3)_L\times SU(3)_R$$ S U ( 3 ) L × S U ( 3 ) R Chiral Perturbation Theory. We review the determination of the $$B_K$$ B K parameter of neutral kaon mixing as well as the additional four B parameters that arise in theories of physics beyond the Standard Model. For the heavy-quark sector, we provide results for $$m_c$$ m c and $$m_b$$ m b as well as those for the decay constants, form factors, and mixing parameters of charmed and bottom mesons and baryons. These are the heavy-quark quantities most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. We review the status of lattice determinations of the strong coupling constant $$\alpha _s$$ α s . We consider nucleon matrix elements, and review the determinations of the axial, scalar and tensor bilinears, both isovector and flavor diagonal. Finally, in this review we have added a new section reviewing determinations of scale-setting quantities.

Published
2022
Full Text
View/download PDF

2. FLAG Review 2019

Author

S. Aoki, Y. Aoki, D. Bečirević, T. Blum, G. Colangelo, S. Collins, M. Della Morte, P. Dimopoulos, S. Dürr, H. Fukaya, M. Golterman, Steven Gottlieb, R. Gupta, S. Hashimoto, U. M. Heller, G. Herdoiza, R. Horsley, A. Jüttner, T. Kaneko, C.-J. D. Lin, E. Lunghi, R. Mawhinney, A. Nicholson, T. Onogi, C. Pena, A. Portelli, A. Ramos, S. R. Sharpe, J. N. Simone, S. Simula, R. Sommer, R. Van de Water, A. Vladikas, U. Wenger, and H. Wittig

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We review lattice results related to pion, kaon, D-meson, B-meson, and nucleon physics with the aim of making them easily accessible to the nuclear and particle physics communities. More specifically, we report on the determination of the light-quark masses, the form factor $$f_+(0)$$ f+(0) arising in the semileptonic $$K \rightarrow \pi $$ K→π transition at zero momentum transfer, as well as the decay constant ratio $$f_K/f_\pi $$ fK/fπ and its consequences for the CKM matrix elements $$V_{us}$$ Vus and $$V_{ud}$$ Vud . Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of $$SU(2)_L\times SU(2)_R$$ SU(2)L×SU(2)R and $$SU(3)_L\times SU(3)_R$$ SU(3)L×SU(3)R Chiral Perturbation Theory. We review the determination of the $$B_K$$ BK parameter of neutral kaon mixing as well as the additional four B parameters that arise in theories of physics beyond the Standard Model. For the heavy-quark sector, we provide results for $$m_c$$ mc and $$m_b$$ mb as well as those for D- and B-meson decay constants, form factors, and mixing parameters. These are the heavy-quark quantities most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. We review the status of lattice determinations of the strong coupling constant $$\alpha _s$$ αs . Finally, in this review we have added a new section reviewing results for nucleon matrix elements of the axial, scalar and tensor bilinears, both isovector and flavor diagonal.

Published
2020
Full Text
View/download PDF

3. Recent Advancements in the Regeneration of Auditory Hair Cells and Hearing Restoration

Author

Rahul Mittal, Desiree Nguyen, Amit P. Patel, Luca H. Debs, Jeenu Mittal, Denise Yan, Adrien A. Eshraghi, Thomas R. Van De Water, and Xue Z. Liu

Subjects
auditory hair cells, hair cell regeneration, hearing loss, gene therapy, stem cell therapy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways that facilitate these responses can result in severe deficits, including hearing loss and vestibular dysfunction. Hearing is affected by both environmental and genetic factors, with impairment of auditory function being the most common neurosensory disorder affecting 1 in 500 newborns, as well as having an impact on the majority of elderly population. Damage to auditory sensory cells is not reversible, and if sufficient damage and cell death have taken place, the resultant deficit may lead to permanent deafness. Cochlear implants are considered to be one of the most successful and consistent treatments for deaf patients, but only offer limited recovery at the expense of loss of residual hearing. Recently there has been an increased interest in the auditory research community to explore the regeneration of mammalian auditory hair cells and restoration of their function. In this review article, we examine a variety of recent therapies, including genetic, stem cell and molecular therapies as well as discussing progress being made in genome editing strategies as applied to the restoration of hearing function.

Published
2017
Full Text
View/download PDF

6. Design, construction and operation of the ProtoDUNE-SP Liquid Argon TPC

Author

Abud, A. Abed Abi, B. Acciarri, R. Acero, M. A. Adames, M. R. Adamov, G. Adams, D. Adinolfi, M. Aduszkiewicz, A. and Aguilar, J. Ahmad, Z. Ahmed, J. Ali-Mohammadzadeh, B. and Alion, T. Allison, K. Monsalve, S. Alonso Alrashed, M. and Alt, C. Alton, A. Amedo, P. Anderson, J. and Andreopoulos, C. Andreotti, M. Andrews, M. P. Andrianala, F. and Andringa, S. Anfimov, N. Ankowski, A. Antoniassi, M. and Antonova, M. Antoshkin, A. Antusch, S. Aranda-Fernandez, A. and Ariga, A. Arnold, L. O. Arroyave, M. A. Asaadi, J. and Asquith, L. Aurisano, A. Aushev, V Autiero, D. and Ayala-Torres, M. Azfar, F. Back, A. Back, H. Back, J. J. and Backhouse, C. Baesso, P. Bagaturia, I Bagby, L. and Balashov, N. Balasubramanian, S. Baldi, P. Baller, B. and Bambah, B. Barao, F. Barenboim, G. Barker, G. J. and Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. and Barros, A. Barros, N. Barrow, J. L. Basharina-Freshville, A. and Bashyal, A. Basque, V Belchior, E. Battat, J. B. R. and Battisti, F. Bay, F. Alba, J. L. Bazo Beacom, J. F. and Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. and Bellini, V Beltramello, O. Belver, D. Benekos, N. and Montiel, C. Benitez Neves, F. Bento Berger, J. Berkman, S. and Bernardini, P. Berner, R. M. Berns, H. Bertolucci, S. and Betancourt, M. Betancur Rodriguez, A. Bevan, A. Bezerra, T. J. C. Bhattacharjee, M. Bhuller, S. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Blaszczyk, F. D. M. Blazey, G. C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. and Bomben, L. Bonesini, M. Bongrand, M. Bonini, F. and Booth, A. Booth, C. Boran, F. Bordoni, S. Borkum, A. and Boschi, T. Bostan, N. Bour, P. Bourgeois, C. Boyd, S. B. and Boyden, D. Bracinik, J. Braga, D. Brailsford, D. and Branca, A. Brandt, A. Bremer, J. Brew, C. Brianne, E. and Brice, S. J. Brizzolari, C. Bromberg, C. Brooijmans, G. and Brooke, J. Bross, A. Brunetti, G. Brunetti, M. and Buchanan, N. Budd, H. Butorov, I Cagnoli, I Caiulo, D. and Calabrese, R. Calafiura, P. Calcutt, J. Calin, M. and Calvez, S. Calvo, E. Caminata, A. Campanelli, M. and Cankocak, K. Caratelli, D. Carini, G. Carlus, B. and Carneiro, M. F. Carniti, P. Terrazas, I. Caro Carranza, H. and Carroll, T. Casta, J. F. Castillo, A. Castromonte, C. and Catano-Mur, E. Cattadori, C. Cavalier, F. Cavanna, F. and Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. Chappell, A. Chardonnet, E. and Charitonidis, N. Chatterjee, A. Chattopadhyay, S. Chen, H. and Chen, K. Chen, M. Chen, Y. Chen, Z. Cheon, Y. and Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. and Chisnall, G. Cho, K. Choate, S. Chokheli, D. Chong, P. S. Choubey, S. Christensen, A. Christian, D. and Christodoulou, G. Chukanov, A. Chung, M. Church, E. and Cicero, V Clarke, P. Coan, T. E. Cocco, A. G. Coelho, J. A. B. Conley, E. Conley, R. Conrad, J. M. Convery, M. and Copello, S. Corwin, L. Valentim, R. Cremaldi, L. and Cremonesi, L. Crespo-Anadon, I, J. Crisler, M. Cristaldo, E. and Cross, R. Cudd, A. Cuesta, C. Cui, Y. Cussans, D. and Dabrowski, M. Dalager, O. da Motta, H. Peres, L. Da Silva David, C. David, Q. Davies, G. S. Davini, S. and Dawson, J. De, K. De Almeida, R. M. Debbins, P. De Bonis, I Decowski, M. P. de Gouvea, A. De Holanda, P. C. and Astiz, I. L. De Icaza Deisting, A. De Jong, P. Delbart, A. and Delepine, D. Delgado, M. Dell'Acqua, A. De Lurgio, P. and de Mello Neto, J. R. T. DeMuth, D. M. Dennis, S. and Densham, C. Deptuch, G. W. De Roeck, A. De Romeri, V De Souza, G. Devi, R. Dharmapalan, R. Dias, M. Diaz, F. and Diaz, J. S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. and Doering, D. Dolan, S. Dolek, F. Dolinski, M. J. and Domine, L. Douglas, D. Douillet, D. Drake, G. Drielsma, F. Duarte, L. Duchesneau, D. Duffy, K. Dunne, P. and Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. A. and Dyshkant, A. S. Eads, M. Earle, A. Edmunds, D. Eisch, J. and Emberger, L. Emery, S. Ereditato, A. Erjavec, T. and Escobar, C. O. Eurin, G. Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. Fani, M. Farnese, C. and Farzan, Y. Fedoseev, D. Felix, J. Feng, Y. and Fernandez-Martinez, E. Fernandez Menendez, P. Fernandez Morales, M. Ferraro, F. Fields, L. Filip, P. Filthaut, F. and Fiorentini, A. Fiorini, M. Fitzpatrick, R. S. Flanagan, W. and Fleming, B. Flight, R. Forero, V, D. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. and Freestone, J. Fried, J. Friedland, A. Robayo, F. Fuentes and Fuess, S. Furic, I Furmanski, A. P. Gabrielli, A. Gago, A. Gallagher, H. Gallas, A. Gallego-Ros, A. Gallice, N. and Galymov, V Gamberini, E. Gamble, T. Ganacim, F. and Gandhi, R. Gandrajula, R. Gao, F. Gao, S. Garcia, A. C. B. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Gauvreau, J. Ge, G. Gelli, B. Gendotti, A. and Gent, S. Ghorbani-Moghaddam, Z. Giammaria, P. Giammaria, T. Gibin, D. Gil-Botella, I Gilligan, S. Girerd, C. and Giri, A. K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. and Gollwitzer, K. Gomes, R. A. Gomez Bermeo, V, L. Gomez Fajardo, L. S. Gonnella, F. Gonzalez-Cuevas, J. A. Gonzalez Diaz, D. Gonzalez-Lopez, M. Goodman, M. C. Goodwin, O. and Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gran, R. Granados, E. Granger, P. Grant, A. and Grant, C. Gratieri, D. Green, P. Greenler, L. Greer, J. and Grenard, J. Griffith, W. C. Groh, M. Grudzinski, J. and Grzelak, K. Gu, W. Guardincerri, E. Guarino, V Guarise, M. Guenette, R. Guerard, E. Guerzoni, M. Guglielmi, A. and Guo, B. Guthikonda, K. K. Gutierrez, R. Guzowski, P. and Guzzo, M. M. Gwon, S. Ha, C. Habig, A. Hadavand, H. and Haenni, R. Hahn, A. Haiston, J. Hamacher-Baumann, P. and Hamernik, T. Hamilton, P. Han, J. Harris, D. A. and Hartnell, J. Harton, J. Hasegawa, T. Hasnip, C. Hatcher, R. Hatfield, K. W. Hatzikoutelis, A. Hayes, C. and Hayrapetyan, K. Hays, J. Hazen, E. He, M. Heavey, A. and Heeger, K. M. Heise, J. Hennessy, K. Henry, S. and Morquecho, M. A. Hernandez Herner, K. Hertel, L. Hewes, J. and Higuera, A. Hill, T. Hillier, S. J. Himmel, A. and Hirsch, L. R. Ho, J. Hoff, J. Holin, A. Hoppe, E. and Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. and Howell, R. Hristova, I Hronek, M. S. Huang, J. Huang, J. and Hugon, J. Iles, G. Ilic, N. Iliescu, A. M. and Illingworth, R. Ingratta, G. Ioannisian, A. Isenhower, L. and Itay, R. Izmaylov, A. Jackson, C. M. Jain, V James, E. Jang, W. Jargowsky, B. Jediny, F. Jena, D. Jeong, Y. S. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. and Jipa, A. Johnson, R. Johnston, N. Jones, B. Jones, S. B. and Judah, M. Jung, C. K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I Kalra, D. Kakorin, I and Kalitkina, A. Kamiya, F. Kaneshige, N. Karagiorgi, G. and Karaman, G. Karcher, A. Karolak, M. Karyotakis, Y. and Kasai, S. Kasetti, S. P. Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. Kemularia, O. and Ketchum, W. Kettell, S. H. Khabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kolupaeva, L. Korablev, D. Kordosky, M. and Kosc, T. Kose, U. Kostelecky, V. A. Kothekar, K. and Krennrich, F. Kreslo, I Kropp, W. Kudenko, Y. and Kudryavtsev, V. A. Kulagin, S. Kumar, J. Kumar, P. and Kunze, P. Kuruppu, C. Kus, V Kutter, T. Kvasnicka, J. and Kwak, D. Lambert, A. Land, B. J. Lande, K. Lane, C. E. Lang, K. Langford, T. Langstaff, M. Larkin, J. and Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Laurenti, G. Lawrence, A. Lazanu, I LaZur, R. Lazzaroni, M. and Le, T. Leardini, S. Learned, J. LeBrun, P. LeCompte, T. and Lee, C. Lee, S. Y. Miotto, G. Lehmann Lehnert, R. de Oliveira, M. A. Leigui Leitner, M. Lepin, L. M. Li, L. and Li, S. W. Li, T. Li, Y. Liao, H. Lin, C. S. Lin, Q. and Lin, S. Ling, J. Lister, A. Littlejohn, B. R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I and Long, K. Loo, K. Lord, T. LoSecco, J. M. Louis, W. C. and Lu, X-G Luk, K. B. Luo, X. Luppi, E. Lurkin, N. and Lux, T. Luzio, V. P. MacFarlane, D. Machado, A. A. and Machado, P. Macias, C. T. Macier, J. R. Maddalena, A. and Madera, A. Madigan, P. Magill, S. Mahn, K. Maio, A. and Major, A. Maloney, J. A. Mandrioli, G. Mandujano, R. C. and Maneira, J. Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique Manyam, V. N. Manzanillas, L. and Marchan, M. Marchionni, A. Marciano, W. Marfatia, D. and Mariani, C. Maricic, J. Marie, R. Marinho, F. Marino, A. D. Marsden, D. Marshak, M. Marshall, C. M. Marshall, J. and Marteau, J. Martin-Albo, J. Martinez, N. Caicedo, D. A. Martinez Martynenko, S. Mascagna, V Mason, K. Mastbaum, A. Masud, M. Matichard, F. Matsuno, S. Matthews, J. and Mauger, C. Mauri, N. Mavrokoridis, K. Mawby, I Mazza, R. and Mazzacane, A. Mazzucato, E. McAskill, T. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. McNab, A. and Mefodiev, A. Mehta, P. Melas, P. Mena, O. Menary, S. and Mendez, H. Mendez, P. Menegolli, A. Meng, G. Messier, M. D. Metcalf, W. Mettler, T. Mewes, M. Meyer, H. Miao, T. Michna, G. Miedema, T. Mikola, V Milincic, R. and Miller, G. Miller, W. Mills, J. Milne, C. Mineev, O. and Miranda, O. G. Miryala, S. Mishra, C. S. Mishra, S. R. and Mislivec, A. Mladenov, D. Mocioiu, I Moffat, K. Moggi, N. Mohanta, R. Mohayai, T. A. Mokhov, N. Molina, J. and Bueno, L. Molina Montagna, E. Montanari, A. Montanari, C. and Montanari, D. Montano Zetina, L. M. Moon, J. Moon, S. H. and Mooney, M. Moor, A. F. Moreno, D. Morris, C. Mossey, C. Motuk, E. Moura, C. A. Mousseau, J. Mouster, G. and Mu, W. Mualem, L. Mueller, J. Muether, M. Mufson, S. and Muheim, F. Muir, A. Mulhearn, M. Munford, D. Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. and Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Nath, A. Navas-Nicolas, D. Navrer-Agasson, A. Nayak, N. and Nebot-Guinot, M. Negishi, K. Nelson, J. K. Nesbit, J. and Nessi, M. Newbold, D. Newcomer, M. Newhart, D. Newton, H. Nichol, R. Nicolas-Arnaldos, F. Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Ochoa-Ricoux, J. P. Del Campo, A. Olivares Olivier, A. Olshevskiy, A. Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palacio, G. and Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. and Palomares, C. Palomino-Gallo, J. L. Vazquez, W. Panduro and Pantic, E. Paolone, V Papadimitriou, V Papaleo, R. and Papanestis, A. Paramesvaran, S. Parke, S. Parozzi, E. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. J. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V Peeters, S. J. M. Pennacchio, E. Penzo, A. and Peres, O. L. G. Perry, J. Pershey, D. Pessina, G. and Petrillo, G. Petta, C. Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. Plunkett, R. Poling, R. Pons, X. and Poonthottathil, N. Poppi, F. Pordes, S. Porter, J. and Potekhin, M. Potenza, R. Potukuchi, B. V. K. S. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prest, M. and Prince, S. Psihas, F. Pugnere, D. Qian, X. Bazetto, M. C. Queiroga Raaf, J. L. Radeka, V Rademacker, J. Radics, B. Rafique, A. Raguzin, E. Rai, M. Rajaoalisoa, M. and Rakhno, I Rakotonandrasana, A. Rakotondravohitra, L. and Ramachers, Y. A. Rameika, R. Ramirez Delgado, M. A. Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Raut, S. and Razakamiandra, R. F. Rea, E. Real, J. S. Rebel, B. and Reggiani-Guzzo, M. Rehak, T. Reichenbacher, J. Reitzner, S. D. Sfar, H. Rejeb Renshaw, A. Rescia, S. Resnati, F. and Reynolds, A. Ribas, M. Riboldi, S. Riccio, C. Riccobene, G. Rice, L. C. J. Ricol, J. Rigamonti, A. Rigaut, Y. and Rivera, D. Robert, A. Rochester, L. Roda, M. Rodrigues, P. Alonso, M. J. Rodriguez Bonilla, E. Rodriguez Rondon, J. Rodriguez Villa, L. A. Romo Rosauro-Alcaraz, S. Rosenberg, M. Rosier, P. Roskovec, B. Rossella, M. Rossi, M. and Rout, J. Roy, P. Roy, S. Rubbia, A. Rubbia, C. and Rubio, F. C. Russell, B. Ruterbories, D. Rybnikov, A. and Saa-Hernandez, A. Saakyan, R. Sacerdoti, S. Safford, T. and Sahu, N. Sala, P. Samios, N. Samoylov, O. Sanchez, M. C. and Sandberg, V Sanders, D. A. Sankey, D. Santana, S. and Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. and Sarcevic, I Savage, G. Savinov, V Scaramelli, A. and Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. and Schifano, S. Schlabach, P. Schmitz, D. Scholberg, K. and Schukraft, A. Segreto, E. Selyunin, A. Senise, C. R. and Sensenig, J. Seoane, M. Seong, I Sergi, A. Sgalaberna, D. Shaevitz, M. H. Shafaq, S. Shamma, M. Sharankova, R. and Sharma, H. R. Sharma, R. Kumar, R. Shaw, T. and Shepherd-Themistocleous, C. Sheshukov, A. Shin, S. and Shoemaker, I Shooltz, D. Shrock, R. Siegel, H. Simard, L. Simon, F. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, L. Singh, V Sipos, R. Sippach, F. W. Sirri, G. Sitraka, A. Siyeon, K. Skarpaas, K. and Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. and Snider, E. L. Snopok, P. Snowden-Ifft, D. Nunes, M. Soares and Sobel, H. Soderberg, M. Sokolov, S. Solano Salinas, C. J. Soldner-Rembold, S. Soleti, S. R. Solomey, N. and Solovov, V Sondheim, W. E. Sorel, M. Sotnikov, A. and Soto-Oton, J. Sousa, A. Soustruznik, K. Spagliardi, F. and Spanu, M. Spitz, J. Spooner, N. J. C. Spurgeon, K. and Staley, R. Stancari, M. Stanco, L. Stanley, R. Stein, R. and Steiner, H. M. Lisboa, A. F. Steklain Stewart, J. and Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Suarez, J. G. and Sullivan, H. Summers, D. Surdo, A. Susic, V Suter, L. Sutera, C. M. Svoboda, R. Szczerbinska, B. Szelc, A. M. Tanaka, H. A. Oregui, B. Tapia Tapper, A. Tariq, S. and Tatar, E. Tayloe, R. Teklu, A. M. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thakore, T. and Thea, A. Thompson, J. L. Thorn, C. Timm, S. C. and Tishchenko, V Todd, J. Tomassetti, L. Tonazzo, A. and Torbunov, D. Torti, M. Tortola, M. Tortorici, F. Tosi, N. Totani, D. Toups, M. Touramanis, C. Travaglini, R. and Trevor, J. Trilov, S. Trzaska, W. H. Tsai, Y. Tsai, Y-T Tsamalaidze, Z. Tsang, V, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. Tzanov, M. Uboldi, L. Uchida, M. A. Urheim, J. Usher, T. Uzunyan, S. Vagins, M. R. and Vahle, P. Valdiviesso, G. A. Valencia, E. Pia, V and Vallari, Z. Vallazza, E. Valle, J. W. F. Vallecorsa, S. and Van Berg, R. Van de Water, R. G. Varanini, F. Vargas, D. and Varner, G. Vasel, J. Vasina, S. Vasseur, G. Vaughan, N. and Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. and Vermeulen, M. A. Verzocchi, M. Vicenzi, M. de Souza, H. Vieira Vignoli, C. Vilela, C. Viren, B. Vrba, T. and Wachala, T. Waldron, V, A. Wallbank, M. Wallis, C. Wang, H. Wang, J. Wang, L. Wang, M. H. L. S. Wang, Y. and Wang, Y. Warburton, K. Warner, D. Wascko, M. O. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. White, A. and Whitehead, L. H. Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wisniewski, W. and Wolcott, J. Wongjirad, T. Wood, A. Wood, K. and Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. and Xiao, Y. Xie, F. Yandel, E. Yang, G. Yang, K. Yang, S. Yang, T. Yankelevich, A. Yershov, N. Yonehara, K. and Young, T. Yu, B. Yu, H. Yu, H. Yu, J. Yuan, W. and Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. and Zazueta, L. Zeller, G. P. Zennamo, J. Zeug, K. and Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zilberman, P. and Zimmerman, E. D. Zito, M. Zucchelli, S. Zuklin, J. and Zutshi, V Zwaska, R. DUNE Collaboration

Abstract

The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber (LArTPC) that was constructed and operated in the CERN North Area at the end of the H4 beamline. This detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment (DUNE), which will be constructed at the Sandford Underground Research Facility (SURF) in Lead, South Dakota, U.S.A. The ProtoDUNE-SP detector incorporates full-size components as designed for DUNE and has an active volume of 7 x 6 x 7.2 m3. The H4 beam delivers incident particles with well-measured momenta and high-purity particle identification. ProtoDUNE-SP's successful operation between 2018 and 2020 demonstrates the effectiveness of the single-phase far detector design. This paper describes the design, construction, assembly and operation of the detector components.

Published
2022

7. Review of Particle Physics: 2022

Author

Workman, R.L., V.D. Burkert, V. Crede, E. Klempt, U. Thoma, L. Tiator, K. Agashe, G. Aielli, B.C. Allanach, C. Amsler, M. Antonelli, E.C. Aschenauer, D.M. Asner, H. Baer, Sw. Banerjee, R.M. Barnett, L. Baudis, C.W. Bauer, J.J. Beatty, V.I. Belousov, J. Beringer, A. Bettini, O. Biebel, K.M. Black, E. Blucher, R. Bonventre, V.V. Bryzgalov, O. Buchmuller, M.A. Bychkov, R.N. Cahn, M. Carena, A. Ceccucci, A. Cerri, R. Sekhar Chivukula, G. Cowan, K. Cranmer, O. Cremonesi, G. D'Ambrosio, T. Damour, D. de Florian, A. de Gouvêa, T. DeGrand, P. de Jong, S. Demers, B.A. Dobrescu, M. D'Onofrio, M. Doser, H.K. Dreiner, P. Eerola, U. Egede, S. Eidelman, A.X. El-Khadra, J. Ellis, S.C. Eno, J. Erler, V.V. Ezhela, W. Fetscher, B.D. Fields, A. Freitas, H. Gallagher, Y. Gershtein, T. Gherghetta, M.C. Gonzalez-Garcia, M. Goodman, C. Grab, A.V. Gritsan, C. Grojean, D.E. Groom, M. Grünewald, A. Gurtu, T. Gutsche, H.E. Haber, Matthieu Hamel, C. Hanhart, S. Hashimoto, Y. Hayato, A. Hebecker, S. Heinemeyer, J.J. Hernández-Rey, K. Hikasa, J. Hisano, A. Höcker, J. Holder, L. Hsu, J. Huston, T. Hyodo, Al. Ianni, M. Kado, M. Karliner, U.F. Katz, M. Kenzie, V.A. Khoze, S.R. Klein, F. Krauss, M. Kreps, P. Križan, B. Krusche, Y. Kwon, O. Lahav, J. Laiho, L.P. Lellouch, J. Lesgourgues, A.R. Liddle, Z. Ligeti, C.-J. Lin, C. Lippmann, T.M. Liss, L. Littenberg, C. Lourenço, K.S. Lugovsky, S.B. Lugovsky, A. Lusiani, Y. Makida, F. Maltoni, T. Mannel, A.V. Manohar, W.J. Marciano, A. Masoni, J. Matthews, U.-G. Meißner, I.-A. Melzer-Pellmann, M. Mikhasenko, D.J. Miller, D. Milstead, R.E. Mitchell, K. Mönig, P. Molaro, F. Moortgat, M. Moskovic, K. Nakamura, M. Narain, P. Nason, S. Navas, A. Nelles, M. Neubert, P. Nevski, Y. Nir, K.A. Olive, C. Patrignani, J.A. Peacock, V.A. Petrov, E. Pianori, A. Pich, A. Piepke, F. Pietropaolo, A. Pomarol, S. Pordes, S. Profumo, A. Quadt, K. Rabbertz, J. Rademacker, G. Raffelt, M. Ramsey-Musolf, B.N. Ratcliff, P. Richardson, A. Ringwald, D.J. Robinson, S. Roesler, S. Rolli, A. Romaniouk, L.J. Rosenberg, J.L. Rosner, G. Rybka, M.G. Ryskin, R.A. Ryutin, Y. Sakai, S. Sarkar, F. Sauli, O. Schneider, S. Schönert, K. Scholberg, A.J. Schwartz, J. Schwiening, D. Scott, F. Sefkow, U. Seljak, V. Sharma, S.R. Sharpe, V. Shiltsev, G. Signorelli, M. Silari, F. Simon, T. Sjöstrand, P. Skands, T. Skwarnicki, G.F. Smoot, A. Soffer, M.S. Sozzi, S. Spanier, C. Spiering, A. Stahl, S.L. Stone, Y. Sumino, M.J. Syphers, F. Takahashi, M. Tanabashi, J. Tanaka, M. Taševský, K. Terao, K. Terashi, J. Terning, R.S. Thorne, M. Titov, N.P. Tkachenko, D.R. Tovey, K. Trabelsi, P. Urquijo, G. Valencia, R. Van de Water, N. Varelas, G. Venanzoni, L. Verde, I. Vivarelli, P. Vogel, W. Vogelsang, V. Vorobyev, S.P. Wakely, W. Walkowiak, C.W. Walter, D. Wands, D.H. Weinberg, E.J. Weinberg, N. Wermes, M. White, L.R. Wiencke, S. Willocq, C.G. Wohl, C.L. Woody, W.-M. Yao, M. Yokoyama, R. Yoshida, G. Zanderighi, G.P. Zeller, O.V. Zenin, R.-Y. Zhu, Shi-Lin Zhu, F. Zimmermann, P.A. Zyla, J. Anderson, T. Basaglia, P. Schaffner, and W. Zheng

Subjects
Nuclear Physics - Theory, Particle Physics - Experiment, Particle Physics - Theory, Particle Physics - Phenomenology
Abstract

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 2,143 new measurements from 709 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search limits are listed in Summary Tables. We give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 120 reviews are many that are new or heavily revised, including a new review on Machine Learning, and one on Spectroscopy of Light Meson Resonances. The Review is divided into two volumes. Volume 1 includes the Summary Tables and 97 review articles. Volume 2 consists of the Particle Listings and contains also 23 reviews that address specific aspects of the data presented in the Listings. The complete Review (both volumes) is published online on the website of the Particle Data Group (pdg.lbl.gov) and in a journal. Volume 1 is available in print as the PDG Book. A Particle Physics Booklet with the Summary Tables and essential tables, figures, and equations from selected review articles is available in print, as a web version optimized for use on phones, and as an Android app.

Published
2022

8. Molecular Regulation of Auditory Hair Cell Death and Approaches to Protect Sensory Receptor Cells and/or Stimulate Repair Following Acoustic Trauma

Author

Christine T DINH, Stefania eGONCALVES, Esperanza eBAS, Thomas R VAN DE WATER, and Azel eZINE

Subjects
Apoptosis, Cochlea, Inflammation, Necrosis, repair, Trauma, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Loss of auditory sensory hair cells is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory hair cells that occur in response to ototoxic and traumatic stressor events. The roles of inflammatory processes, oxidative stress, mitochondrial damage, cell death receptors, members of the MAPK signal pathway and pro- and anti- cell death members of the Bcl-2 family are explored. The molecular interaction of these signal pathways that initiates the loss of stress damaged auditory hair cells following acoustic trauma is covered and possible therapeutic interventions that may protect these sensory damaged auditory hair cells from loss via apoptotic or non-apoptotic cell death are explored.

Published
2015
Full Text
View/download PDF

9. Historical Aspects of Gene Therapy and Stem Cell Therapy in the Treatment of Hearing and Balance Disorder

Author

Thomas R. Van De Water

Subjects
0301 basic medicine, medicine.medical_specialty, Histology, Hearing loss, Genetic enhancement, medicine.medical_treatment, Psychological intervention, Vectors in gene therapy, History, 21st Century, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Progenitor cell, Intensive care medicine, Hearing Disorders, Ecology, Evolution, Behavior and Systematics, Balance disorders, Genetic Therapy, Stem-cell therapy, History, 20th Century, 030104 developmental biology, Vestibular Diseases, Anatomy, medicine.symptom, Stem cell, 030217 neurology & neurosurgery, Stem Cell Transplantation, Biotechnology
Abstract

This review presents many but not all the major historical events that have led to our current understanding of gene and stem cell therapies for the treatment of hearing and balance disorders in animal models of these disorders. In order to better understand the application of these emerging therapies to the treatment of inner ear disorders in a clinical setting, it has been necessary to provide some genetic and pathobiology backgrounds from both animal models and clinical disorders. The current focus and goal of gene and stem cell therapies are directed toward understanding the effective treatment of animal models that mimic human disorders of hearing and balance. This approach not only addresses the most effective ways to deliver the gene or stem cell therapies to affected inner ears, it also provides an assessment of the efficacy of the applied therapy(s) in achieving either partial or full restoration of either hearing and/or balance within the animal models receiving these therapeutic interventions. This review also attempts to present a realistic assessment of how close the research fields of gene and stem cell therapies are to application for the treatment of human disorders in a clinical setting. Progress made in developing these novel therapies toward clinical applications would not have been possible without the many pioneering studies and discoveries achieved by the investigators cited in this review. There were also many other excellent studies performed by gifted investigators that were not able to be included within this review. Anat Rec, 303:390-407, 2020. © 2019 American Association for Anatomy.

Published
2020
Full Text
View/download PDF

10. TGF β‐1 and WNT Signaling Pathways Collaboration Associated with Cochlear Implantation Trauma‐Induced Fibrosis

Author

Mir R. Anwar, Thomas R. Van De Water, and Esperanza Bas

Subjects
0301 basic medicine, Histology, Transforming Growth Factor beta1, Mice, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, medicine, Animals, Inner ear, Ecology, Evolution, Behavior and Systematics, Tissue homeostasis, Cell Proliferation, business.industry, Wnt signaling pathway, Fibroblasts, medicine.disease, Cochlear Implantation, Cell biology, Wnt Proteins, Crosstalk (biology), 030104 developmental biology, medicine.anatomical_structure, Chronic inflammatory response, sense organs, Hair cell, Anatomy, business, Myofibroblast, 030217 neurology & neurosurgery, Signal Transduction, Biotechnology
Abstract

The crosstalk between TGF-β1 and WNT pathways has been proven to regulate aspects of the development and tissue homeostasis processes. Recently, it has been demonstrated this collaboration also takes place during fibrotic diseases, where TGF-β1 activates the WNT/β-catenin pathway that results in dedifferentiation of fibroblasts into myofibroblasts, increased production of extracellular matrix components and fibrosis. Independent studies show the functions of these molecules during the development of the inner ears in several different species. However, little is known about the collaboration between TGF-β1 and WNT in the injured inner ear and particularly how this collaboration affects the fibrotic process that often occurs following cochlear implantation. First, we used a cochlear explant model to study the effect of electrode insertion trauma and TGF-β1 signaling in activation of the WNT pathway. Finally, adult TopGal mutant mice were used in vivo to track the activation of the WNT/β-catenin in response to EIT. A chronic inflammatory response, increased cell proliferation and tissue remodeling are hallmarks of fibrotic disease. This study explores and highlights the collaboration between the TGF-β1 and WNT pathways in the trauma-initiated fibrotic process within the implanted cochlea. WNT signaling is involved in the development of the inner ear and therefore a potential target in hair cell regeneration therapies. However, in light of our observations from the current study, manipulation of the WNT pathway by gene therapy techniques in the pathological ear seems a very complex process with an increased risk of inducing excessive fibrosis thereby compromising the efficacy of implant function. Anat Rec, 303:608-618, 2020. © 2019 American Association for Anatomy.

Published
2019
Full Text
View/download PDF

11. Review of Particle Physics (RPP 2020)

Author

P A Zyla, R M Barnett, J Beringer, O Dahl, D A Dwyer, D E Groom, C -J Lin, K S Lugovsky, E Pianori, D J Robinson, C G Wohl, W -M Yao, K Agashe, G Aielli, B C Allanach, C Amsler, M Antonelli, E C Aschenauer, D M Asner, H Baer, Sw Banerjee, L Baudis, C W Bauer, J J Beatty, V I Belousov, S Bethke, A Bettini, O Biebel, K M Black, E Blucher, O Buchmuller, V Burkert, M A Bychkov, R N Cahn, M Carena, A Ceccucci, A Cerri, D Chakraborty, R Sekhar Chivukula, G Cowan, G D'Ambrosio, T Damour, D de Florian, A de Gouvêa, T DeGrand, P de Jong, G Dissertori, B A Dobrescu, M D'Onofrio, M Doser, M Drees, H K Dreiner, P Eerola, U Egede, S Eidelman, J Ellis, J Erler, V V Ezhela, W Fetscher, B D Fields, B Foster, A Freitas, H Gallagher, L Garren, H -J Gerber, G Gerbier, T Gershon, Y Gershtein, T Gherghetta, A A Godizov, M C Gonzalez-Garcia, M Goodman, C Grab, A V Gritsan, C Grojean, M Grünewald, A Gurtu, T Gutsche, H E Haber, C Hanhart, S Hashimoto, Y Hayato, A Hebecker, S Heinemeyer, B Heltsley, J J Hernández-Rey, K Hikasa, J Hisano, A Höcker, J Holder, A Holtkamp, J Huston, T Hyodo, K F Johnson, M Kado, M Karliner, U F Katz, M Kenzie, V A Khoze, S R Klein, E Klempt, R V Kowalewski, F Krauss, M Kreps, B Krusche, Y Kwon, O Lahav, J Laiho, L P Lellouch, J Lesgourgues, A R Liddle, Z Ligeti, C Lippmann, T M Liss, L Littenberg, C Lourengo, S B Lugovsky, A Lusiani, Y Makida, F Maltoni, T Mannel, A V Manohar, W J Marciano, A Masoni, J Matthews, U -G Meißner, M Mikhasenko, D J Miller, D Milstead, R E Mitchell, K Mönig, P Molaro, F Moortgat, M Moskovic, K Nakamura, M Narain, P Nason, S Navas, M Neubert, P Nevski, Y Nir, K A Olive, C Patrignani, J A Peacock, S T Petcov, V A Petrov, A Pich, A Piepke, A Pomarol, S Profumo, A Quadt, K Rabbertz, J Rademacker, G Raffelt, H Ramani, M Ramsey-Musolf, B N Ratcliff, P Richardson, A Ringwald, S Roesler, S Rolli, A Romaniouk, L J Rosenberg, J L Rosner, G Rybka, M Ryskin, R A Ryutin, Y Sakai, G P Salam, S Sarkar, F Sauli, O Schneider, K Scholberg, A J Schwartz, J Schwiening, D Scott, V Sharma, S R Sharpe, T Shutt, M Silari, T Sjöstrand, P Skands, T Skwarnicki, G F Smoot, A Soffer, M S Sozzi, S Spanier, C Spiering, A Stahl, S L Stone, Y Sumino, T Sumiyoshi, M J Syphers, F Takahashi, M Tanabashi, J Tanaka, M Taševský, K Terashi, J Terning, U Thoma, R S Thorne, L Tiator, M Titov, N P Tkachenko, D R Tovey, K Trabelsi, P Urquijo, G Valencia, R Van de Water, N Varelas, G Venanzoni, L Verde, M G Vincter, P Vogel, W Vogelsang, A Vogt, V Vorobyev, S P Wakely, W Walkowiak, C W Walter, D Wands, M O Wascko, D H Weinberg, E J Weinberg, M White, L R Wiencke, S Willocq, C L Woody, R L Workman, M Yokoyama, R Yoshida, G Zanderighi, G P Zeller, O V Zenin, R -Y Zhu, S -L Zhu, F Zimmermann, J Anderson, T Basaglia, V S Lugovsky, P Schaffner, W Zheng, P A Zyla, R M Barnett, J Beringer, O Dahl, D A Dwyer, D E Groom, C -J Lin, K S Lugovsky, E Pianori, D J Robinson, C G Wohl, W -M Yao, K Agashe, G Aielli, B C Allanach, C Amsler, M Antonelli, E C Aschenauer, D M Asner, H Baer, Sw Banerjee, L Baudi, C W Bauer, J J Beatty, V I Belousov, S Bethke, A Bettini, O Biebel, K M Black, E Blucher, O Buchmuller, V Burkert, M A Bychkov, R N Cahn, M Carena, A Ceccucci, A Cerri, D Chakraborty, R Sekhar Chivukula, G Cowan, G D'Ambrosio, T Damour, D de Florian, A de Gouvêa, T DeGrand, P de Jong, G Dissertori, B A Dobrescu, M D'Onofrio, M Doser, M Dree, H K Dreiner, P Eerola, U Egede, S Eidelman, J Elli, J Erler, V V Ezhela, W Fetscher, B D Field, B Foster, A Freita, H Gallagher, L Garren, H -J Gerber, G Gerbier, T Gershon, Y Gershtein, T Gherghetta, A A Godizov, M C Gonzalez-Garcia, M Goodman, C Grab, A V Gritsan, C Grojean, M Grünewald, A Gurtu, T Gutsche, H E Haber, C Hanhart, S Hashimoto, Y Hayato, A Hebecker, S Heinemeyer, B Heltsley, J J Hernández-Rey, K Hikasa, J Hisano, A Höcker, J Holder, A Holtkamp, J Huston, T Hyodo, K F Johnson, M Kado, M Karliner, U F Katz, M Kenzie, V A Khoze, S R Klein, E Klempt, R V Kowalewski, F Krau, M Krep, B Krusche, Y Kwon, O Lahav, J Laiho, L P Lellouch, J Lesgourgue, A R Liddle, Z Ligeti, C Lippmann, T M Li, L Littenberg, C Lourengo, S B Lugovsky, A Lusiani, Y Makida, F Maltoni, T Mannel, A V Manohar, W J Marciano, A Masoni, J Matthew, U -G Meißner, M Mikhasenko, D J Miller, D Milstead, R E Mitchell, K Mönig, P Molaro, F Moortgat, M Moskovic, K Nakamura, M Narain, P Nason, S Nava, M Neubert, P Nevski, Y Nir, K A Olive, C Patrignani, J A Peacock, S T Petcov, V A Petrov, A Pich, A Piepke, A Pomarol, S Profumo, A Quadt, K Rabbertz, J Rademacker, G Raffelt, H Ramani, M Ramsey-Musolf, B N Ratcliff, P Richardson, A Ringwald, S Roesler, S Rolli, A Romaniouk, L J Rosenberg, J L Rosner, G Rybka, M Ryskin, R A Ryutin, Y Sakai, G P Salam, S Sarkar, F Sauli, O Schneider, K Scholberg, A J Schwartz, J Schwiening, D Scott, V Sharma, S R Sharpe, T Shutt, M Silari, T Sjöstrand, P Skand, T Skwarnicki, G F Smoot, A Soffer, M S Sozzi, S Spanier, C Spiering, A Stahl, S L Stone, Y Sumino, T Sumiyoshi, M J Sypher, F Takahashi, M Tanabashi, J Tanaka, M Taševský, K Terashi, J Terning, U Thoma, R S Thorne, L Tiator, M Titov, N P Tkachenko, D R Tovey, K Trabelsi, P Urquijo, G Valencia, R Van de Water, N Varela, G Venanzoni, L Verde, M G Vincter, P Vogel, W Vogelsang, A Vogt, V Vorobyev, S P Wakely, W Walkowiak, C W Walter, D Wand, M O Wascko, D H Weinberg, E J Weinberg, M White, L R Wiencke, S Willocq, C L Woody, R L Workman, M Yokoyama, R Yoshida, G Zanderighi, G P Zeller, O V Zenin, R -Y Zhu, S -L Zhu, F Zimmermann, J Anderson, T Basaglia, V S Lugovsky, P Schaffner, and W Zheng

Subjects
High Energy Physics::Phenomenology, HEP, Particle Data Group
Abstract

he Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,324 new measurements from 878 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search limits are listed in Summary Tables. We give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 120 reviews are many that are new or heavily revised, including a new review on High Energy Soft QCD and Diffraction and one on the Determination of CKM Angles from B Hadrons. The Review is divided into two volumes. Volume 1 includes the Summary Tables and 98 review articles. Volume 2 consists of the Particle Listings and contains also 22 reviews that address specific aspects of the data presented in the Listings. The complete Review (both volumes) is published online on the website of the Particle Data Group (pdg.lbl.gov) and in a journal. Volume 1 is available in print as the PDG Book. A Particle Physics Booklet with the Summary Tables and essential tables, figures, and equations from selected review articles is available in print and as a web version optimized for use on phones as well as an Android app.

Published
2020

12. Deep underground neutrino experiment (DUNE) near detector conceptual design report

Author

Abud, A.A. Abi, B. Acciarri, R. Acero, M.A. Adamov, G. Adams, D. Adinolfi, M. Aduszkiewicz, A. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S.A. Alrashed, M. Alt, C. Alton, A. Amedo, P. Anderson, J. Andreopoulos, C. Andrews, M.P. Andrianala, F. Andringa, S. Anfimov, N. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L.O. Arroyave, M.A. Asaadi, J. Aurisano, A. Aushev, V. Autiero, D. Ayala-Torres, M. Azfar, F. Back, A. Back, H. Back, J.J. Backhouse, C. Baesso, P. Bagaturia, I. Bagby, L. Balasubramanian, S. Baldi, P. Baller, B. Bambah, B. Barao, F. Barenboim, G. Barker, G.J. Barkhouse, W. Barnes, C. Barr, G. Monarca, J.B. Barros, N. Barrow, J.L. Basharina-Freshville, A. Bashyal, A. Basque, V. Belchior, E. Battat, J.B.R. Battisti, F. Bay, F. Alba, J.L.B. Beacom, J.F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. Beltramello, O. Belver, D. Benekos, N. Neves, F.B. Berkman, S. Bernardini, P. Berner, R.M. Berns, H. Bertolucci, S. Betancourt, M. Rodríguez, A.B. Bhattacharjee, M. Bhuller, S. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Blaszczyk, F.D.M. Blazey, G.C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. Bomben, L. Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Bourgeois, C. Boyd, S.B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S.J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Brunetti, M. Buchanan, N. Budd, H. Cagnoli, I. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. Caminata, A. Campanelli, M. Cankocak, K. Caratelli, D. Carini, G. Carlus, B. Carniti, P. Terrazas, I.C. Carranza, H. Carroll, T. Castaño Forero, J.F. Castillo, A. Castromonte, C. Catano-Mur, E. Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Villanueva, A.C. Chalifour, M. Chappell, A. Chardonnet, E. Charitonidis, N. Chatterjee, A. Chattopadhyay, S. Chen, H. Chen, M. Chen, Y. Chen, Z. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Chisnall, G. Cho, K. Choate, S. Chokheli, D. Choubey, S. Christensen, A. Christian, D. Christodoulou, G. Chukanov, A. Church, E. Cicero, V. Clarke, P. Coan, T.E. Cocco, A.G. Coelho, J.A.B. Conley, E. Conley, R. Conrad, J.M. Convery, M. Copello, S. Corwin, L. Cremaldi, L. Cremonesi, L. Crespo-Anadón, J.I. Cristaldo, E. Cross, R. Cudd, A. Cuesta, C. Cui, Y. Cussans, D. Dabrowski, M. Dalager, O. Da Motta, H. Da Silva Peres, L. David, C. David, Q. Davies, G.S. Davini, S. Dawson, J. De, K. De Almeida, R.M. Debbins, P. De Bonis, I. Decowski, M.P. De Gouvêa, A. De Holanda, P.C. De Icaza Astiz, I.L. Deisting, A. De Jong, P. Delbart, A. Delepine, D. Delgado, M. Dell’Acqua, A. De Lurgio, P. De Mello Neto, J.R.T. De Muth, D.M. Dennis, S. Densham, C. Deptuch, G.W. De Roeck, A. De Romeri, V. De Souza, G. Dharmapalan, R. Diaz, F. Díaz, J.S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolan, S. Dolinski, M.J. Domine, L. Douglas, D. Douillet, D. Drake, G. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D.A. Dyshkant, A.S. Eads, M. Earle, A. Edmunds, D. Eisch, J. Emberger, L. Emery, S. Ereditato, A. Escobar, C.O. Eurin, G. Evans, J.J. Ewart, E. Ezeribe, A.C. Fahey, K. Falcone, A. Farnese, C. Farzan, Y. Felix, J. Carneiro Da Silva, M.F. Fernandez-Martinez, E. Fernandez Menendez, P. Ferraro, F. Fields, L. Filthaut, F. Fiorentini, A. Fitzpatrick, R.S. Flanagan, W. Fleming, B. Flight, R. Forero, D.V. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. Freestone, J. Fried, J. Friedland, A. Fuess, S. Furic, I. Furmanski, A.P. Gabrielli, A. Gago, A. Gallagher, H. Gallas, A. Gallego-Ros, A. Gallice, N. Galymov, V. Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. Gao, F. Gao, S. Garcia-Gamez, D. García-Peris, M.Á. Gardiner, S. Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I. Gilligan, S. Girerd, C. Giri, A.K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. Gollwitzer, K. Gomes, R.A. Gomez Bermeo, L.V. Gomez Fajardo, L.S. Gonnella, F. Gonzalez-Cuevas, J.A. Gonzalez-Diaz, D. Gonzalez-Lopez, M. Goodman, M.C. Goodwin, O. Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gran, R. Granados, E. Granger, P. Grant, A. Grant, C. Gratieri, D. Green, P. Greenler, L. Greer, J. Griffith, W.C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. Guenette, R. Guerard, E. Guerzoni, M. Guglielmi, A. Guo, B. Guthikonda, K.K. Gutierrez, R. Guzowski, P. Guzzo, M.M. Gwon, S. Habig, A. Hadavand, H. Haenni, R. Hahn, A. Haiston, J. Hamacher-Baumann, P. Hamernik, T. Hamilton, P. Han, J. Harris, D.A. Hartnell, J. Harton, J. Hasegawa, T. Hasnip, C. Hatcher, R. Hatfield, K.W. Hatzikoutelis, A. Hayes, C. Hazen, E. Heavey, A. Heeger, K.M. Heise, J. Hennessy, K. Henry, S. Hernandez Morquecho, M.A. Herner, K. Hertel, L. Hewes, J. Higuera, A. Hill, T. Hillier, S.J. Himmel, A. Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G.A. Hostert, M. Hourlier, A. Howard, B. Howell, R. Huang, J. Huang, J. Hugon, J. Iles, G. Ilic, N. Iliescu, A.M. Illingworth, R. Ingratta, G. Ioannisian, A. Isenhower, L. Itay, R. Izmaylov, A. Jackson, S. Jain, V. James, E. Jargowsky, B. Jediny, F. Jena, D. Jeong, Y.S. Jesús-Valls, C. Ji, X. Jiang, L. Jiménez, S. Jipa, A. Johnson, R. Johnston, N. Jones, B. Jones, S.B. Judah, M. Jung, C.K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. Kakorin, I. Kamiya, F. Kaneshige, N. Karagiorgi, G. Karaman, G. Karcher, A. Karolak, M. Karyotakis, Y. Kasai, S. Kasetti, S.P. Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K.J. Kemp, E. Kemularia, O. Ketchum, W. Kettell, S.H. Khabibullin, M. Khotjantsev, A. Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. Klein, J. Koehler, K. Koerner, L.W. Kohn, S. Koller, P.P. Kolupaeva, L. Kordosky, M. Kosc, T. Kose, U. Kostelecký, V.A. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. Kudryavtsev, V.A. Kulagin, S. Kumar, J. Kumar, P. Kumar, R. Kunze, P. Kurita, N. Kuruppu, C. Kus, V. Kutter, T. Lambert, A. Land, B. Lande, K. Lane, C.E. Lang, K. Langford, T. Larkin, J. Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Laurenti, G. Lawrence, A. Lazanu, I. Lazur, R. Le, T. Leardini, S. Learned, J. Lebrun, P. Lecompte, T. Lehmann Miotto, G. Lehnert, R. Leigui De Oliveira, M.A. Leitner, M. Li, L. Li, S.W. Li, T. Li, Y. Liao, H. Lin, C.S. Lin, Q. Lin, S. Lister, A. Littlejohn, B.R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. Loo, K. Lorca, D. Lord, T. Losecco, J.M. Louis, W.C. Lu, X.-G. Luk, K.B. Luo, X. Lurkin, N. Lux, T. Luzio, V.P. Macfarlane, D. Machado, A.A. Machado, P. Macias, C.T. Macier, J.R. Maddalena, A. Madera, A. Madigan, P. Magill, S. Mahn, K. Maio, A. Major, A. Maloney, J.A. Mandrioli, G. Mandujano, R.C. Maneira, J. Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Manrique Plata, M. Manyam, V.N. Manzanillas, L. Marchan, M. Marchionni, A. Marciano, W. Marfatia, D. Mariani, C. Maricic, J. Marie, R. Marinho, F. Marino, A.D. Marsden, D. Marshak, M. Marshall, C.M. Marshall, J. Marteau, J. Martin-Albo, J. Martinez, N. Martinez Caicedo, D.A. Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. Mawby, I. Mazza, R. Mazzacane, A. Mazzucato, E. McAskill, T. McCluskey, E. McConkey, N. McFarland, K.S. McGrew, C. McNab, A. Mefodiev, A. Mehta, P. Melas, P. Mena, O. Menary, S. Mendez, H. Méndez, D.P. Menegolli, A. Meng, G. Messier, M.D. Metcalf, W. Mettler, T. Mewes, M. Meyer, H. Miao, T. Michna, G. Miedema, T. Migenda, J. Mikola, V. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O.G. Miryala, S. Mishra, C.S. Mishra, S.R. Mislivec, A. Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. Mohayai, T.A. Mokhov, N. Molina, J. Molina Bueno, L. Montanari, A. Montanari, C. Montanari, D. Montagna, E. Montano Zetina, L.M. Moon, J. Mooney, M. Moor, A.F. Moreno, D. Morris, C. Mossey, C. Motuk, E. Moura, C.A. Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. Mufson, S. Muheim, F. Muir, A. Mulhearn, M. Munford, D. Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. Navas-Nicolás, D. Navrer-Agasson, A. Nayak, N. Nebot-Guinot, M. Negishi, K. Nelson, J.K. Nesbit, J. Nessi, M. Newbold, D. Newcomer, M. Newhart, D. Newton, H. Niccolo, M. Nichol, R. Nicolas-Arnaldos, F. Nicoletta, M. Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. Nowak, J.A. Oberling, M. Ochoa-Ricoux, J.P. Olivares Del Campo, A. Olivier, A. Olshevskiy, A. Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palacio, G. Palamara, O. Palestini, S. Paley, J.M. Pallavicini, M. Palomares, C. Palomino-Gallo, J.L. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. Pasternak, J. Pater, J. Patrick, C. Patrizii, L. Patterson, R.B. Patton, S.J. Patzak, T. Paudel, A. Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S.J.M. Pennacchio, E. Penzo, A. Peres, O.L.G. Perry, J. Pershey, D. Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. Plunkett, R. Poling, R. Pons, X. Poonthottathil, N. Poppi, F. Pordes, S. Porter, J. Potekhin, M. Potenza, R. Potukuchi, B.V.K.S. Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. Prince, S. Pugnere, D. Qian, X. Queiroga Bazetto, M.C. Raaf, J.L. Radeka, V. Rademacker, J. Radics, B. Rafique, A. Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I. Rakotonandrasana, A. Rakotondravohitra, L. Ramachers, Y.A. Rameika, R. Ramirez Delgado, M.A. Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Raut, S. Razakamiandra, R.F. Real, J.S. Rebel, B. Reggiani-Guzzo, M. Rehak, T. Reichenbacher, J. Reitzner, S.D. Rejeb Sfar, H. Renshaw, A. Rescia, S. Resnati, F. Reynolds, A. Riccio, C. Riccobene, G. Rice, L.C.J. Ricol, J. Rigamonti, A. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. Rodrigues, P. Rodriguez Alonso, M.J. Rodriguez Bonilla, E. Rodriguez Rondon, J. Rosauro-Alcaraz, S. Rosenberg, M. Rosier, P. Roskovec, B. Rossella, M. Rout, J. Roy, P. Roy, S. Rubbia, A. Rubbia, C. Rubio, F.C. Russell, B. Ruterbories, D. Saakyan, R. Sacerdoti, S. Safford, T. Sahay, R. Sahu, N. Sala, P. Samios, N. Samoylov, O. Sanchez, M.C. Sanders, D.A. Sankey, D. Santana, S. Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I. Savage, G. Savinov, V. Scaramelli, A. Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. Sensenig, J. Seong, I. Sergi, A. Sgalaberna, D. Shaevitz, M.H. Shafaq, S. Shamma, M. Sharankova, R. Sharma, H.R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simon, F. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F.W. Sirri, G. Sitraka, A. Siyeon, K. Skarpaas, K. Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. Snider, E.L. Snopok, P. Soares Nunes, M. Sobel, H. Soderberg, M. Solano Salinas, C.J. Söldner-Rembold, S. Soleti, S. Solomey, N. Solovov, V. Sondheim, W.E. Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. Spagliardi, F. Spanu, M. Spitz, J. Spooner, N.J.C. Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Stanley, R. Stein, R. Steiner, H.M. Stewart, J. Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Suarez, J.G. Sullivan, H. Summers, D. Surdo, A. Susic, V. Suter, L. Sutera, C.M. Svoboda, R. Szczerbinska, B. Szelc, A.M. Talaga, R. Tanaka, H.A. Oregui, B.T. Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A.M. Tenti, M. Terao, K. Ternes, C.A. Terranova, F. Testera, G. Thea, A. Thompson, J.L. Thorn, C. Timm, S.C. Todd, J. Tonazzo, A. Torbunov, D. Torti, M. Tortola, M. Tortorici, F. Totani, D. Toups, M. Touramanis, C. Tosi, N. Travaglini, R. Trevor, J. Trilov, S. Trzaska, W.H. Tsai, Y.T. Tsamalaidze, Z. Tsang, K.V. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. Tzanov, M. Uchida, M.A. Urheim, J. Usher, T. Uzunyan, S. Vagins, M.R. Vahle, P. Valdiviesso, G.A. Valencia, E. Valerio, P. Vallari, Z. Valle, J.W.F. Vallecorsa, S. Van Berg, R. Van De Water, R.G. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasina, S. Vasseur, G. Vaughan, N. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M.A. Verzocchi, M. Vicenzi, M. Vieira De Souza, H. Vignoli, C. Vilela, C. Viren, B. Vrba, T. Wachala, T. Waldron, A.V. Wallbank, M. Wang, H. Wang, J. Wang, L. Wang, M.H.L.S. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. White, A. Whitehead, L.H. Whittington, D. Wilking, M.J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R.J. Wolcott, J. Wongjirad, T. Wood, A. Wood, K. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yandel, E. Yang, G. Yang, K. Yang, S. Yang, T. Yankelevich, A. Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, H. Yu, J. Yuan, W. Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeit, G. Zeller, G.P. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zilberman, P. Zimmerman, E.D. Zito, M. Zucchelli, S. Zuklin, J. Zutshi, V. Zwaska, R. DUNE Collaboration

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Experiment
Abstract

The Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. The experiment consists of a near detector, sited close to the source of the beam, and a far detector, sited along the beam at a large distance. This document, the DUNE Near Detector Conceptual Design Report (CDR), describes the design of the DUNE near detector and the science program that drives the design and technology choices. The goals and requirements underlying the design, along with projected performance are given. It serves as a starting point for a more detailed design that will be described in future documents. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Published
2021

13. Supernova neutrino burst detection with the deep underground neutrino experiment: DUNE Collaboration

Author

Abi, B. Acciarri, R. Acero, M.A. Adamov, G. Adams, D. Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Alonso Monsalve, S. Alt, C. Anderson, J. Andreopoulos, C. Andrews, M.P. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L.O. Arroyave, M.A. Asaadi, J. Aurisano, A. Aushev, V. Autiero, D. Azfar, F. Back, H. Back, J.J. Backhouse, C. Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G.J. Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. Barros, N. Barrow, J.L. Bashyal, A. Basque, V. Bay, F. Alba, J.L.B. Beacom, J.F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. Beltramello, O. Belver, D. Benekos, N. Bento Neves, F. Berger, J. Berkman, S. Bernardini, P. Berner, R.M. Berns, H. Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Blanco Siffert, B. Blaszczyk, F.D.M. Blazey, G.C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S.B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S.J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. Caratelli, D. Carini, G. Carlus, B. Carniti, P. Caro Terrazas, I. Carranza, H. Castillo, A. Castromonte, C. Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. Choubey, S. Christensen, A. Christian, D. Christodoulou, G. Church, E. Clarke, P. Coan, T.E. Cocco, A.G. Coelho, J.A.B. Conley, E. Conrad, J.M. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadón, J.I. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. Cussans, D. Dabrowski, M. da Motta, H. Da Silva Peres, L. David, C. David, Q. Davies, G.S. Davini, S. Dawson, J. De, K. De Almeida, R.M. Debbins, P. De Bonis, I. Decowski, M.P. de Gouvêa, A. De Holanda, P.C. De Icaza Astiz, I.L. Deisting, A. De Jong, P. Delbart, A. Delepine, D. Delgado, M. Dell-Acqua, A. De Lurgio, P. de Mello Neto, J.R.T. DeMuth, D.M. Dennis, S. Densham, C. Deptuch, G. De Roeck, A. De Romeri, V. De Vries, J.J. Dharmapalan, R. Dias, M. Diaz, F. Díaz, J.S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M.J. Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D.A. Dyshkant, A.S. Eads, M. Edmunds, D. Eisch, J. Emery, S. Ereditato, A. Escobar, C.O. Escudero Sanchez, L. Evans, J.J. Ewart, E. Ezeribe, A.C. Fahey, K. Falcone, A. Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. Fernandez Menendez, P. Ferraro, F. Fields, L. Filkins, A. Filthaut, F. Fitzpatrick, R.S. Flanagan, W. Fleming, B. Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. Freestone, J. Fried, J. Friedland, A. Fuess, S. Furic, I. Furmanski, A.P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. Gao, S. Garcia-Gamez, D. García-Peris, M.Á. Gardiner, S. Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I. Girerd, C. Giri, A.K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. Gollwitzer, K. Gomes, R.A. Gomez Bermeo, L.V. Gomez Fajardo, L.S. Gonnella, F. Gonzalez-Cuevas, J.A. Goodman, M.C. Goodwin, O. Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. Griffith, W.C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. Guenette, R. Guglielmi, A. Guo, B. Guthikonda, K.K. Gutierrez, R. Guzowski, P. Guzzo, M.M. Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. Hamilton, P. Han, J. Harder, K. Harris, D.A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. Heeger, K.M. Heise, J. Hennessy, K. Henry, S. Hernandez Morquecho, M.A. Herner, K. Hertel, L. Hesam, A.S. Hewes, J. Higuera, A. Hill, T. Hillier, S.J. Himmel, A. Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G.A. Hostert, M. Hourlier, A. Howard, B. Howell, R. Huang, J. Huang, J. Hugon, J. Iles, G. Ilic, N. Iliescu, A.M. Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. James, E. Jargowsky, B. Jediny, F. Jesùs-Valls, C. Ji, X. Jiang, L. Jiménez, S. Jipa, A. Joglekar, A. Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C.K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. Karyotakis, Y. Kasai, S. Kasetti, S.P. Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K.J. Kemp, E. Ketchum, W. Kettell, S.H. Khabibullin, M. Khotjantsev, A. Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. Klein, J. Koehler, K. Koerner, L.W. Kohn, S. Koller, P.P. Kordosky, M. Kosc, T. Kose, U. Kostelecký, V.A. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. Kudryavtsev, V.A. Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V. Kutter, T. Lambert, A. Lande, K. Lane, C.E. Lang, K. Langford, T. Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I. LaZur, R. Le, T. Learned, J. LeBrun, P. Lehmann Miotto, G. Lehnert, R. Leigui de Oliveira, M.A. Leitner, M. Leyton, M. Li, L. Li, S. Li, S.W. Li, T. Li, Y. Liao, H. Lin, C.S. Lin, S. Lister, A. Littlejohn, B.R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. Loo, K. Lorca, D. Lord, T. LoSecco, J.M. Louis, W.C. Luk, K.B. Luo, X. Lurkin, N. Lux, T. Luzio, V.P. MacFarland, D. Machado, A.A. Machado, P. Macias, C.T. Macier, J.R. Maddalena, A. Madigan, P. Magill, S. Mahn, K. Maio, A. Major, A. Maloney, J.A. Mandrioli, G. Maneira, J. Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Manrique Plata, M. Marchionni, A. Marciano, W. Marfatia, D. Mariani, C. Maricic, J. Marinho, F. Marino, A.D. Marshak, M. Marshall, C. Marshall, J. Marteau, J. Martin-Albo, J. Martinez, N. Martinez Caicedo, D.A. Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. McConkey, N. McFarland, K.S. McGrew, C. McNab, A. Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. Menary, S. Mendez, H. Menegolli, A. Meng, G. Messier, M.D. Metcalf, W. Mewes, M. Meyer, H. Miao, T. Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O.G. Miryala, S. Mishra, C.S. Mishra, S.R. Mislivec, A. Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. Mohayai, T.A. Mokhov, N. Molina, J. Molina Bueno, L. Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L.M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C.A. Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. Mufson, S. Muheim, F. Muir, A. Mulhearn, M. Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. Navas-Nicolás, D. Nayak, N. Nebot-Guinot, M. Necib, L. Negishi, K. Nelson, J.K. Nesbit, J. Nessi, M. Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. Nowak, J.A. Oberling, M. Olivares Del Campo, A. Olivier, A. Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J.M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. Pasternak, J. Pater, J. Patrick, C. Patrizii, L. Patterson, R.B. Patton, S.J. Patzak, T. Paudel, A. Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S.J.M. Penichot, Y. Pennacchio, E. Penzo, A. Peres, O.L.G. Perry, J. Pershey, D. Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. Pillow, J. Pinzino, J. Plunkett, R. Poling, R. Pons, X. Poonthottathil, N. Pordes, S. Potekhin, M. Potenza, R. Potukuchi, B.V.K.S. Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. Pugnere, D. Qi, K. Qian, X. Raaf, J.L. Raboanary, R. Radeka, V. Rademacker, J. Radics, B. Rafique, A. Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I. Rakotondramanana, H.T. Rakotondravohitra, L. Ramachers, Y.A. Rameika, R. Ramirez Delgado, M.A. Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J.S. Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. Reichenbacher, J. Reitzner, S.D. Renshaw, A. Rescia, S. Resnati, F. Reynolds, A. Riccobene, G. Rice, L.C.J. Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. Rodrigues, P. Rodriguez Alonso, M.J. Rodriguez Rondon, J. Roeth, A.J. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M.C. Sanders, D.A. Sankey, D. Santana, S. Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I. Savage, G. Savinov, V. Scaramelli, A. Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. Sensenig, J. Seong, I. Sergi, A. Sergiampietri, F. Sgalaberna, D. Shaevitz, M.H. Shafaq, S. Shamma, M. Sharma, H.R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F.W. Sirri, G. Sitraka, A. Siyeon, K. Smargianaki, D. Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. Snopok, P. Soares Nunes, M. Sobel, H. Soderberg, M. Solano Salinas, C.J. Söldner-Rembold, S. Solomey, N. Solovov, V. Sondheim, W.E. Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. Spagliardi, F. Spanu, M. Spitz, J. Spooner, N.J.C. Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H.M. Stewart, J. Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V. Suter, L. Sutera, C.M. Svoboda, R. Szczerbinska, B. Szelc, A.M. Talaga, R. Tanaka, H.A. Tapia Oregui, B. Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A.M. Tenti, M. Terao, K. Ternes, C.A. Terranova, F. Testera, G. Thea, A. Thompson, J.L. Thorn, C. Timm, S.C. Tonazzo, A. Torti, M. Tórtola, M. Tortorici, F. Totani, D. Toups, M. Touramanis, C. Trevor, J. Trzaska, W.H. Tsai, Y.T. Tsamalaidze, Z. Tsang, K.V. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. Tzanov, M. Uchida, M.A. Urheim, J. Usher, T. Vagins, M.R. Vahle, P. Valdiviesso, G.A. Valencia, E. Vallari, Z. Valle, J.W.F. Vallecorsa, S. Van Berg, R. Van de Water, R.G. Vanegas Forero, D. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M.A. Verzocchi, M. Vieira de Souza, H. Vignoli, C. Vilela, C. Viren, B. Vrba, T. Wachala, T. Waldron, A.V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M.R. White, A. Whitehead, L.H. Whittington, D. Wilking, M.J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R.J. Wolcott, J. Wongjirad, T. Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G.P. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E.D. Zito, M. Zucchelli, S. Zuklin, J. Zutshi, V. Zwaska, R.

Subjects
Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Physics::Geophysics
Abstract

The deep underground neutrino experiment (DUNE), a 40-kton underground liquid argon time projection chamber experiment, will be sensitive to the electron-neutrino flavor component of the burst of neutrinos expected from the next Galactic core-collapse supernova. Such an observation will bring unique insight into the astrophysics of core collapse as well as into the properties of neutrinos. The general capabilities of DUNE for neutrino detection in the relevant few- to few-tens-of-MeV neutrino energy range will be described. As an example, DUNE’s ability to constrain the νe spectral parameters of the neutrino burst will be considered. © 2021, The Author(s).

Published
2021

14. <scp>l</scp>-N-acetylcysteine protects outer hair cells against TNFα initiated ototoxicity in vitro

Author

Chhavi Gupta, Jeenu Mittal, Jamal Ahmed, Thomas R. Van De Water, Kadri Ila, Adrien A. Eshraghi, and Joshua A. Tillinger

Subjects
Drug Evaluation, Preclinical, In Vitro Techniques, medicine.disease_cause, Glutathione Synthase, Rats, Sprague-Dawley, Lipid peroxidation, Andrology, Acetylcysteine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Ototoxicity, medicine, Animals, Hearing Loss, 030223 otorhinolaryngology, Membrane Potential, Mitochondrial, chemistry.chemical_classification, Aldehydes, Reactive oxygen species, Tumor Necrosis Factor-alpha, Chemistry, Free Radical Scavengers, General Medicine, Glutathione, medicine.disease, Hair Cells, Auditory, Outer, Oxidative Stress, medicine.anatomical_structure, Otorhinolaryngology, Organ of Corti, Hair cell, Reactive Oxygen Species, 030217 neurology & neurosurgery, Oxidative stress, medicine.drug
Abstract

OBJECTIVE The present study is aimed at determining the efficacy and exploring the mechanisms by which l-N-acetylcysteine (l-NAC) provides protection against tumor necrosis factor-alpha (TNFα)-induced oxidative stress damage and hair cell loss in 3-day-old rat organ of Corti (OC) explants. Previous work has demonstrated a high level of oxidative stress in TNFα-challenged OC explants. TNFα can potentially play a significant role in hair cell loss following an insult to the inner ear. l-NAC has shown to provide effective protection against noise-induced hearing loss in laboratory animals but mechanisms of this otoprotective effect are not well-defined. DESIGN Rat OC explants were exposed to either: (1) saline control (N = 12); (2) TNFα (2 μg/ml, N = 12); (3) TNFα+l-NAC (5 mM, N = 12); (4) TNFα+l-NAC (10 mM, N = 12); or (5) l-NAC (10 mM, N = 12). Outer hair cell (OHC) density, levels of reactive oxygen species (ROS), lipid peroxidation of cell membranes, gluthathione activity, and mitochondrial viability were assayed. RESULTS l-NAC (5 and 10 mM) provided protection for OHCs from ototoxic level of TNFα in OC explants. Groups treated with TNFα+l-NAC (5 mM) showed a highly significant reduction of both ROS (p

Published
2018
Full Text
View/download PDF

15. Effects of Intratympanic Dexamethasone on High-Dose Radiation Ototoxicity In Vivo

Author

Stefania Goncalves, Kyle R. Padgett, John Dinh, Christine T. Dinh, Esperanza Bas, Si Chen, Nagy Elsayyad, Perry Johnson, Fred F. Telischi, and Thomas R. Van De Water

Subjects
Male, medicine.medical_specialty, Tympanic Membrane, Hearing loss, Audiology, Dexamethasone, 03 medical and health sciences, 0302 clinical medicine, Ototoxicity, In vivo, Internal medicine, otorhinolaryngologic diseases, medicine, Animals, Hearing Loss, Cochlea, Radiation, Absolute threshold of hearing, business.industry, medicine.disease, Sensory Systems, Rats, Hair Cells, Auditory, Outer, Auditory brainstem response, medicine.anatomical_structure, Endocrinology, Otorhinolaryngology, 030220 oncology & carcinogenesis, Evoked Potentials, Auditory, sense organs, Neurology (clinical), Hair cell, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Stereotactic radiosurgery for lateral skull base tumors can cause hearing loss when the cochleae are exposed to high doses of single-fraction radiation. Currently, there are no known nondosimetric preventative treatments for radiation-induced ototoxicity.Intratympanic (IT) dexamethasone (DXM), a synthetic steroid, protects against radiation-induced auditory hair cell (HC) and hearing losses in rats in vivo.Seven rats received radiation (12 Gy) to both cochleae. In irradiated rats and six nonirradiated rats, IT DXM was randomized to one ear, while tympanic puncture without DXM was performed on the contralateral ear. Baseline and 4-week postradiation auditory-evoked potential tests were performed. The cochleae were processed for HC viability.Cochleae exposed to radiation demonstrated more outer HC (OHC) loss in all turns than nonirradiated ears (p 0.05). OHCs were more susceptible to radiation injury than inner HCs in the middle and basal turns (p 0.05). In irradiated cochleae, there was a nonsignificant trend for less OHC loss with IT DXM in the basal turn when compared with placebo. IT DXM did not improve radiation-induced hearing threshold shifts; however, a high rate of tympanic membrane perforations occurred with irradiated ears which may contribute to this finding.Radiation induced loss of OHCs in all turns of the cochlea. IT DXM reduced OHC loss in the basal turn of irradiated ears; however, this finding did not achieve statistical significance. Although IT DXM did not affect radiation-induced hearing threshold shifts in adult rats in vivo, this may be due to a high rate of tympanic membrane perforations.

Published
2017
Full Text
View/download PDF

16. Volume IV The DUNE far detector single-phase technology

Author

Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. and Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. and Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V and Autiero, D. Azfar, F. Back, H. Back, J. J. Backhouse, C. and Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. and Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G. and Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. and Barros, N. Barrow, J. L. Bashyal, A. Basque, V Bay, F. Bazo Alba, J. Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V Beltramello, O. Belver, D. Benekos, N. Neves, F. Bento Berger, J. and Berkman, S. Bernardini, P. Berner, R. M. Berns, H. and Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. and Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. and Bilki, B. Bishai, M. Bitadze, A. Blake, A. Siffert, B. Blanco Blaszczyk, F. Blazey, G. Blucher, E. and Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. and Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. and Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S. and Boyden, D. Bracinik, J. Braga, D. Brailsford, D. and Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S. J. and Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. and Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. and Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. and Caratelli, D. Carini, G. Carlus, B. Carniti, P. and Terrazas, I. Caro Carranza, H. Castillo, A. Castromonte, C. and Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. and Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. and Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. and Choubey, S. Christensen, A. Christian, D. Christodoulou, G. and Church, E. Clarke, P. Coan, T. E. Cocco, A. G. and Coelho, J. Conley, E. Conrad, J. Convery, M. Corwin, L. and Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadon, I, J. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. and Cussans, D. Dabrowski, M. Da Motta, H. Peres, L. Da Silva and David, Q. Davies, G. S. Davini, S. Dawson, J. De, K. and De Almeida, R. M. Debbins, P. De Bonis, I Decowski, M. and De Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza and Deisting, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. De Mello Neto, J. R. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V De Vries, J. Dharmapalan, R. and Dias, M. Diaz, F. Diaz, J. Di Domizio, S. Di Giulio, L. and Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. Domine, L. and Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. and Dyshkant, A. Eads, M. Edmunds, D. Eisch, J. Emery, S. and Ereditato, A. Escobar, C. Sanchez, L. Escudero Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. and Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. and Fernandez Menendez, P. Ferraro, F. Fields, L. Filkins, A. and Filthaut, F. Fitzpatrick, R. S. Flanagan, W. Fleming, B. and Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. and Franco, D. Freeman, J. Freestone, J. Fried, J. and Friedland, A. Fuess, S. Furic, I Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V and Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. and Gao, S. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. and Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I Girerd, C. Giri, A. Gnani, D. Gogota, O. Gold, M. and Gollapinni, S. Gollwitzer, K. Gomes, R. A. Gomez Bermeo, L. and Gomez Fajardo, L. S. Gonnella, F. Gonzalez-Cuevas, J. and Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. and Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. and Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. and Griffith, C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V Guenette, R. Guglielmi, A. Guo, B. and Guthikonda, K. Gutierrez, R. Guzowski, P. Guzzo, M. M. and Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. and Hamilton, P. Han, J. Harder, K. Harris, D. A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. and Heeger, K. M. Hennessy, K. Henry, S. Hernandez Morquecho, M. and Herner, K. Hertel, L. Hesam, A. S. Hewes, J. and Pichardo, A. Higuera Hill, T. Hillier, S. J. Himmel, A. and Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. Howell, R. and Huang, J. Huang, J. Hugon, J. Iles, G. Iliescu, A. M. and Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. and James, E. Jargowsky, B. Jediny, F. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Joglekar, A. and Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C. and Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I and Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. and Karyotakis, Y. Kasai, S. Kasetti, S. P. Kashur, L. and Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. and Ketchum, W. Kettell, S. Khabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kordosky, M. Kosc, T. Kose, U. Kostelecky, V Kothekar, K. Krennrich, F. Kreslo, I Kudenko, Y. and Kudryavtsev, V Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V Kutter, T. Lambert, A. Lande, K. Lane, C. E. Lang, K. Langford, T. Lasorak, P. Last, D. and Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G. Lehmann and Lehnert, R. de Oliveira, M. Leigui Leitner, M. Leyton, M. and Li, L. Li, S. Li, S. Li, T. Li, Y. Liao, H. and Lin, C. Lin, S. Lister, A. Littlejohn, B. R. Liu, J. and Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I Long, K. and Loo, K. Lorca, D. Lord, T. LoSecco, J. Louis, W. C. and Luk, K. Luo, X. Lurkin, N. Lux, T. Luzio, V. P. and MacFarland, D. Machado, A. Machado, P. Macias, C. and Macier, J. Maddalena, A. Madigan, P. Magill, S. Mahn, K. and Maio, A. Maloney, J. A. Mandrioli, G. Maneira, J. C. and Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique Marchionni, A. Marciano, W. Marfatia, D. and Mariani, C. Maricic, J. Marinho, F. Marino, A. D. and Marshak, M. Marshall, C. Marshall, J. Marteau, J. and Martin-Albo, J. Martinez, N. Caicedo, D. A. Martinez and Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. and Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. McNab, A. and Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. and Menary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, M. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. Mishra, S. Mislivec, A. Mladenov, D. Mocioiu, I Moffat, K. Moggi, N. Mohanta, R. and Mohayai, T. A. Mokhov, N. Molina, J. A. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. and Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. and Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. Necib, L. and Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. and Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V Papadimitriou, V and Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V Peeters, S. J. Penichot, Y. Pennacchio, E. and Penzo, A. Peres, O. L. Perry, J. Pershey, D. Pessina, G. and Petrillo, G. Petta, C. Petti, R. Piastra, F. and Pickering, L. Pietropaolo, F. Pillow, J. Plunkett, R. and Poling, R. Pons, X. Poonthottathil, N. Pordes, S. and Potekhin, M. Potenza, R. Potukuchi, V, B. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. and Pugnere, D. Qi, K. Qian, X. Raaf, J. Raboanary, R. and Radeka, V Rademacker, J. Radics, B. Rafique, A. and Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I and Rakotondramanana, H. Rakotondravohitra, L. Ramachers, Y. and Rameika, R. Ramirez Delgado, M. Ramson, B. Rappoldi, A. and Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J. and Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. and Reichenbacher, J. Reitzner, S. D. Renshaw, A. Rescia, S. and Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. and Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. and Rodrigues, P. Alonso, M. Rodriguez Rondon, J. Rodriguez and Roeth, A. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. and Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. and Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. and Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M. and Sanders, D. A. Sankey, D. Santana, S. Santos-Maldonado, M. and Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I and Savage, G. Savinov, V Scaramelli, A. Scarff, A. and Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. and Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. and Sensenig, J. Seong, I Sergi, A. Sergiampietri, F. and Sgalaberna, D. Shaevitz, M. Shafaq, S. Shamma, M. and Sharma, H. R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V Sipos, R. Sippach, F. Sirri, G. Sitraka, A. and Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. and Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M. Soares Sobel, H. Soderberg, M. Solano Salinas, C. J. and Soldner-Rembold, S. Solomey, N. Solovov, V Sondheim, W. E. and Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. and Spagliardi, F. Spanu, M. Spitz, J. Spooner, N. J. and Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H. Stewart, J. Stillwell, B. Stock, J. Stocker, F. and Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V Suter, L. Sutera, C. Svoboda, R. Szczerbinska, B. Szelc, A. Talaga, R. and Tanaka, H. Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. Tonazzo, A. Torti, M. Tortola, M. and Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, W. H. Tsai, Y. T. Tsamalaidze, Z. and Tsang, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, M. Uchida, M. A. Urheim, J. Usher, T. and Vagins, M. Vahle, P. Valdiviesso, G. Valencia, E. and Vallari, Z. Valle, J. W. Vallecorsa, S. Van Berg, R. Van de Water, R. G. Forero, D. Vanegas Varanini, F. Vargas, D. and Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M. A. Verzocchi, M. de Souza, H. Vieira Vignoli, C. Vilela, C. Viren, B. and Vrba, T. Wachala, T. Waldron, V, A. Wallbank, M. and Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. and Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M. R. White, A. Whitehead, L. H. and Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wolcott, J. Wongjirad, T. and Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. and Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. and Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. and Zucchelli, S. Zuklin, J. Zutshi, V Zwaska, R. DUNE Collaboration

Published
2020

17. Volume I. Introduction to DUNE

Author

Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. and Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. and Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V. and Autiero, D. Azfar, F. Back, H. Back, J. J. Backhouse, C. and Baesso, P. Bayby, L. Bajou, R. Balasubramanian, S. and Baldi, P. Bambah, B. Barao, F. Barenhoim, G. Barker, G. and Barkhouse, W. Barnes, C. Barr, G. Monarca, J. Barranco and Barros, N. Barrow, J. L. Bashyal, A. Basque, V. Bay, F. Alba, J. Bazo Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. and Beltramello, O. Belver, D. Benckos, N. Neves, F. Bento and Berger, J. Berkman, S. Bernardini, P. Berner, R. M. and Berns, H. Bertolucci, S. Betancourt, M. Bezawada, Y. and Bhattacharjee, M. Bhuyan, B. Biagi, S. Bian, J. and Biassoni, M. Bierv, K. Bilki, B. Bishai, M. Bitadze, A. and Blake, A. Siffert, B. Blanco Blaszczyk, F. Blazey, G. and Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. and Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. and Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S. Bovden, D. Bracinik, J. Braga, D. and Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S. J. Brizzolari, C. Bromherg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Buchanan, N. and Budd, H. Caiulo, D. Calaftura, P. Calcutt, J. Calin, M. and Calvez, S. Calvo, E. Camilleri, L. Caminata, A. and Campanelli, M. Caratelli, D. Carini, G. Carlus, B. and Carniti, P. Terrazas, I. Caro Carranza, H. Castillo, A. and Castromonte, C. Cattadori, C. Cavalier, F. Cavanna, F. and Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. and Chalifour, M. Chang, C. Chardonnet, E. Chatterjee, A. and Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. and Cho, K. Choubey, S. Christensen, A. Christian, D. and Christodoulou, G. Church, E. Clarke, P. Coan, T. E. and Cocco, A. G. Coelho, J. Conley, E. Conrad, J. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. and Crespo-Anadon, J. I. Cristaldo, E. Cross, R. Cuesta, C. and Cui, Y. Cussans, D. Dahrowski, M. Da Motta, H. Da Silva Peres, L. David, Q. Davies, G. S. Davini, S. Dawson, J. and De, K. De Almeida, R. M. Debbins, P. De Bonis, I. and Decowski, M. De Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza Deistin, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. De Mello Neto, J. R. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V. De Vries, J. Dharmapalan, R. and Dias, M. Diaz, F. Diaz, J. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. and Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. and Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. and Dyshkant, A. Eads, M. Edmunds, D. Eisch, J. Emery, S. Ereditato, A. Escobar, C. Escudero Sanchez, L. Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. and Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. and Menendez, P. Fernandez Ferraro, F. Fields, L. Filkins, A. and Filthaut, F. Fitzpatrick, R. S. Flanagan, W. Fleming, B. and Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. and Franco, D. Freeman, J. Freestone, J. Fried, J. and Friedland, A. Fuess, S. Furic, I. Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. and Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. and Gao, S. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. and Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, L. Girerd, C. Giri, A. Gnani, D. Gogota, O. Gold, M. and Gollapinni, S. Gollwitzer, K. Gomes, R. A. Bermeo, L. Gomez and Fajardo, L. S. Gomez Gonnella, F. Gonzalez-Cuevas, J. and Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. and Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. and Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. and Griffith, C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. Guenette, R. Guglielmi, A. Guo, B. and Guthikonda, K. Gutierrez, R. Guzowski, P. Guzzo, M. M. and Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. and Hamilton, P. Han, J. Harder, K. Harris, D. A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. and Heeger, K. M. Hennessy, K. Henry, S. Morquecho, Vi. Hernandez Herner, K. Hertel, L. Hesam, A. S. Hewes, J. and Pichardo, A. Higuera Hill, T. Hillier, S. J. Himmel, A. and Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. Howell, R. and Huang, J. Huang, J. Hugon, J. Iles, G. Iliescu, A. M. and Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. and James, E. Jargowsky, B. Jediny, F. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Joglekar, A. and Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C. and Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. and Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. and Karyotakis, Y. Kasai, S. Kasetti, S. P. Kashur, L. and Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. and Ketchum, W. Kettell, S. Kliabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kordosky, M. Kosc, T. Kose, U. Kostelecky, V. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. and Kudryavtsev, V. Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V. Kutter, T. Lamhert, A. Lande, K. Lane, C. E. Lang, K. Langford, T. Lasorak, P. Last, D. and Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I. LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G. Lehmann and Lehnert, R. de Oliveira, M. Leigui Leitner, M. Leyton, M. and Li, L. Li, S. Li, S. Li, T. Li, Y. Liao, H. and Lin, C. Lin, S. Lister, A. Littlejohn, B. R. Liu, J. and Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. and Loo, K. Lorca, D. Lord, T. LoSecco, J. Louis, W. C. and Luk, K. Luo, X. Lurkin, N. Lux, T. Luzio, V. P. and MacFarland, D. Machado, A. Machado, P. Macias, C. and Macier, J. Maddalena, A. Madigan, P. Magill, S. Mahn, K. and Maio, A. Maloney, J. A. Mandrioli, G. Maneira, J. C. and Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique Marchionni, A. Marciano, W. Marfatia, D. and Mariani, C. Maricic, J. Marinho, F. Marino, A. D. and Marshak, M. Marshall, C. Marshall, J. Marteau, J. and Martin-Alho, J. Martinez, N. Caicedo, D. A. Martinez and Martynenko, S. Mason, K. Masthaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. and Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. McNab, A. and Mefodiev, A. Mehta, P. Melas, P. Mellinato, V. Mena, O. and Mcnary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, V. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. Mishra, S. Mislivec, A. Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. and Mohayai, T. A. Mokhov, N. Molina, J. A. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. and Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. and Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. Necib, L. and Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. and Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S. J. Penichot, Y. Pennacchio, E. and Penzo, A. Peres, O. L. Perry, J. Pershey, D. and Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. and Pickering, L. Pietropaolo, F. Pillows, J. Plunkett, R. and Poling, R. Pons, X. Poonthottathil, N. Pordes, S. and Potekhin, M. Potenza, R. Potukuchi, B. V. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. and Pugnere, D. Qi, K. Qian, X. Raaf, J. Raboanary, R. and Radeka, V. Rademacker, J. Radics, B. Rafique, A. and Raguzin, E. Rai, M. Rajarialisoa, M. Rakhno, I. and Rakotondramanana, H. Rakotondravollitra, L. Ramachers, Y. and Rameika, R. Delgado, Vi. Ramirez Ramson, B. Rappoldi, A. and Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J. and Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. and Reichenbacher, J. Reitzner, S. D. Renshaw, A. Rescia, S. and Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. and Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. and Rodrigues, P. Alonso, M. Rodriguez Rondon, J. Rodriguez and Roeth, A. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. and Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. and Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. and Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M. and Sanders, D. A. Sankey, D. Santana, S. Santos-Maldonado, M. and Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I. and Savage, G. Savinov, V. Scaramelli, A. Scarff, A. and Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. and Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. and Sensenig, J. Seong, I. Sergi, A. Sergiampietri, F. and Sgalaberna, D. Shaevitz, M. Shafaq, S. Shamma, M. and Sharma, H. R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F. Sirri, G. Sitraka, A. and Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. and Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M. Soares Sobel, H. Soderberg, M. Salinas, C. J. Solano and Soldner-Remhold, S. Solomey, N. Solovov, V. Sondheim, W. E. and Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. and Spagliardi, F. Spanu, M. Spitz, J. Spooner, N. J. and Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H. Stewart, J. Stillwell, B. Stock, J. Stocker, F. and Stokes, T. Strait, M. Strauss, T. Strianov, S. Stuart, A. Summers, D. Surdo, A. Susic, V. Suter, L. Sutera, C. Svoboda, R. Szczerbinska, B. Szelc, A. Talaga, R. and Tanaka, H. Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. Tonazzo, A. Torti, M. Tortola, M. and Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, Wh. Tsai, Yt. Tsamalaidze, Z. Tsang, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, Vi. Uchida, Vi. A. Urheim, J. Usher, T. Vagins, Vi. Vahle, P. Valdiviesso, G. Valencia, E. Vallari, Z. and Valle, J. W. Vallecorsa, S. Van Berg, R. Van de Water, R. G. Vanegas Forero, D. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. and Verdugo, A. Vergani, S. Vermeulen, M. A. Verzocchi, M. and Vieira de Souza, H. Vignoli, C. Vilela, C. Viren, B. and Vrba, T. Wachala, T. Waldron, A. V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. and Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. and Wetstein, M. While, M. R. White, A. Whitehead, L. H. and Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. and Wilson, F. Wilson, R. J. Wolcott, J. Wongjirad, T. and Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. and Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. and Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. and Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. and Zuccilelli, S. Zuklin, J. Zuishi, V. Zwaska, R. DUNE Collaboration

Published
2020

18. Long-baseline neutrino oscillation physics potential of the DUNE experiment: DUNE Collaboration

Author

Abi, B. Acciarri, R. Acero, M.A. Adamov, G. Adams, D. Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S.A. Alt, C. Anderson, J. Andreopoulos, C. Andrews, M.P. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L.O. Arroyave, M.A. Asaadi, J. Aurisano, A. Aushev, V. Autiero, D. Azfar, F. Back, H. Back, J.J. Backhouse, C. Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G.J. Barkhouse, W. Barnes, C. Barr, G. Monarca, J.B. Barros, N. Barrow, J.L. Bashyal, A. Basque, V. Bay, F. Alba, J.L.B. Beacom, J.F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. Beltramello, O. Belver, D. Benekos, N. Neves, F.B. Berger, J. Berkman, S. Bernardini, P. Berner, R.M. Berns, H. Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Siffert, B.B. Blaszczyk, F.D.M. Blazey, G.C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S.B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S.J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. Caratelli, D. Carini, G. Carlus, B. Carniti, P. Terrazas, I.C. Carranza, H. Castillo, A. Castromonte, C. Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Villanueva, A.C. Chalifour, M. Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. Choubey, S. Christensen, A. Christian, D. Christodoulou, G. Church, E. Clarke, P. Coan, T.E. Cocco, A.G. Coelho, J.A.B. Conley, E. Conrad, J.M. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadón, J.I. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. Cussans, D. Dabrowski, M. Motta, H. Da Silva Peres, L. David, C. David, Q. Davies, G.S. Davini, S. Dawson, J. De, K. De Almeida, R.M. Debbins, P. De Bonis, I. Decowski, M.P. de Gouvêa, A. De Holanda, P.C. De Icaza Astiz, I.L. Deisting, A. De Jong, P. Delbart, A. Delepine, D. Delgado, M. Dell’Acqua, A. De Lurgio, P. de Mello Neto, J.R.T. DeMuth, D.M. Dennis, S. Densham, C. Deptuch, G. De Roeck, A. De Romeri, V. De Vries, J.J. Dharmapalan, R. Dias, M. Diaz, F. Díaz, J.S. Domizio, S.D. Giulio, L.D. Ding, P. Noto, L.D. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M.J. Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D.A. Dyshkant, A.S. Eads, M. Edmunds, D. Eisch, J. Emery, S. Ereditato, A. Escobar, C.O. Sanchez, L.E. Evans, J.J. Ewart, E. Ezeribe, A.C. Fahey, K. Falcone, A. Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. Menendez, P.F. Ferraro, F. Fields, L. Filkins, A. Filthaut, F. Fitzpatrick, R.S. Flanagan, W. Fleming, B. Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. Freestone, J. Fried, J. Friedland, A. Fuess, S. Furic, I. Furmanski, A.P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. Gao, S. Garcia-Gamez, D. García-Peris, M.Á. Gardiner, S. Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I. Girerd, C. Giri, A.K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. Gollwitzer, K. Gomes, R.A. Bermeo, L.V.G. Fajardo, L.S.G. Gonnella, F. Gonzalez-Cuevas, J.A. Goodman, M.C. Goodwin, O. Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. Griffith, W.C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. Guenette, R. Guglielmi, A. Guo, B. Guthikonda, K.K. Gutierrez, R. Guzowski, P. Guzzo, M.M. Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. Hamilton, P. Han, J. Harder, K. Harris, D.A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. Heeger, K.M. Heise, J. Hennessy, K. Henry, S. Morquecho, M.A.H. Herner, K. Hertel, L. Hesam, A.S. Hewes, J. Higuera, A. Hill, T. Hillier, S.J. Himmel, A. Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G.A. Hostert, M. Hourlier, A. Howard, B. Howell, R. Huang, J. Huang, J. Hugon, J. Iles, G. Ilic, N. Iliescu, A.M. Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. James, E. Jargowsky, B. Jediny, F. Jesùs-Valls, C. Ji, X. Jiang, L. Jiménez, S. Jipa, A. Joglekar, A. Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C.K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. Karyotakis, Y. Kasai, S. Kasetti, S.P. Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K.J. Kemp, E. Ketchum, W. Kettell, S.H. Khabibullin, M. Khotjantsev, A. Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. Klein, J. Koehler, K. Koerner, L.W. Kohn, S. Koller, P.P. Kordosky, M. Kosc, T. Kose, U. Kostelecký, V.A. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. Kudryavtsev, V.A. Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V. Kutter, T. Lambert, A. Lande, K. Lane, C.E. Lang, K. Langford, T. Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I. LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G.L. Lehnert, R. de Oliveira, M.A.L. Leitner, M. Leyton, M. Li, L. Li, S. Li, S.W. Li, T. Li, Y. Liao, H. Lin, C.S. Lin, S. Lister, A. Littlejohn, B.R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. Loo, K. Lorca, D. Lord, T. LoSecco, J.M. Louis, W.C. Luk, K.B. Luo, X. Lurkin, N. Lux, T. Luzio, V.P. MacFarland, D. Machado, A.A. Machado, P. Macias, C.T. Macier, J.R. Maddalena, A. Madigan, P. Magill, S. Mahn, K. Maio, A. Maloney, J.A. Mandrioli, G. Maneira, J. Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M.M. Marchionni, A. Marciano, W. Marfatia, D. Mariani, C. Maricic, J. Marinho, F. Marino, A.D. Marshak, M. Marshall, C. Marshall, J. Marteau, J. Martin-Albo, J. Martinez, N. Caicedo, D.A.M. Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. McConkey, N. McFarland, K.S. McGrew, C. McNab, A. Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. Menary, S. Mendez, H. Menegolli, A. Meng, G. Messier, M.D. Metcalf, W. Mewes, M. Meyer, H. Miao, T. Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O.G. Miryala, S. Mishra, C.S. Mishra, S.R. Mislivec, A. Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. Mohayai, T.A. Mokhov, N. Molina, J. Bueno, L.M. Montanari, A. Montanari, C. Montanari, D. Zetina, L.M.M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C.A. Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. Mufson, S. Muheim, F. Muir, A. Mulhearn, M. Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. Navas-Nicolás, D. Nayak, N. Nebot-Guinot, M. Necib, L. Negishi, K. Nelson, J.K. Nesbit, J. Nessi, M. Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. Nowak, J.A. Oberling, M. Campo, A.O.D. Olivier, A. Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J.M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. Pasternak, J. Pater, J. Patrick, C. Patrizii, L. Patterson, R.B. Patton, S.J. Patzak, T. Paudel, A. Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S.J.M. Penichot, Y. Pennacchio, E. Penzo, A. Peres, O.L.G. Perry, J. Pershey, D. Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. Pillow, J. Pinzino, J. Plunkett, R. Poling, R. Pons, X. Poonthottathil, N. Pordes, S. Potekhin, M. Potenza, R. Potukuchi, B.V.K.S. Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. Pugnere, D. Qi, K. Qian, X. Raaf, J.L. Raboanary, R. Radeka, V. Rademacker, J. Radics, B. Rafique, A. Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I. Rakotondramanana, H.T. Rakotondravohitra, L. Ramachers, Y.A. Rameika, R. Delgado, M.A.R. Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J.S. Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. Reichenbacher, J. Reitzner, S.D. Renshaw, A. Rescia, S. Resnati, F. Reynolds, A. Riccobene, G. Rice, L.C.J. Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. Rodrigues, P. Alonso, M.J.R. Rondon, J.R. Roeth, A.J. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M.C. Sanders, D.A. Sankey, D. Santana, S. Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I. Savage, G. Savinov, V. Scaramelli, A. Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. Sensenig, J. Seong, I. Sergi, A. Sergiampietri, F. Sgalaberna, D. Shaevitz, M.H. Shafaq, S. Shamma, M. Sharma, H.R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F.W. Sirri, G. Sitraka, A. Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M.S. Sobel, H. Soderberg, M. Salinas, C.J.S. Söldner-Rembold, S. Solomey, N. Solovov, V. Sondheim, W.E. Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. Spagliardi, F. Spanu, M. Spitz, J. Spooner, N.J.C. Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H.M. Stewart, J. Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V. Suter, L. Sutera, C.M. Svoboda, R. Szczerbinska, B. Szelc, A.M. Talaga, R. Tanaka, H.A. Oregui, B.T. Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A.M. Tenti, M. Terao, K. Ternes, C.A. Terranova, F. Testera, G. Thea, A. Thompson, J.L. Thorn, C. Timm, S.C. Tonazzo, A. Torti, M. Tortola, M. Tortorici, F. Totani, D. Toups, M. Touramanis, C. Trevor, J. Trzaska, W.H. Tsai, Y.T. Tsamalaidze, Z. Tsang, K.V. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. Tzanov, M. Uchida, M.A. Urheim, J. Usher, T. Vagins, M.R. Vahle, P. Valdiviesso, G.A. Valencia, E. Vallari, Z. Valle, J.W.F. Vallecorsa, S. Van Berg, R. Van de Water, R.G. Forero, D.V. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M.A. Verzocchi, M. de Souza, H.V. Vignoli, C. Vilela, C. Viren, B. Vrba, T. Wachala, T. Waldron, A.V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M.R. White, A. Whitehead, L.H. Whittington, D. Wilking, M.J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R.J. Wolcott, J. Wongjirad, T. Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G.P. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E.D. Zito, M. Zucchelli, S. Zuklin, J. Zutshi, V. Zwaska, R.

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

The sensitivity of the Deep Underground Neutrino Experiment (DUNE) to neutrino oscillation is determined, based on a full simulation, reconstruction, and event selection of the far detector and a full simulation and parameterized analysis of the near detector. Detailed uncertainties due to the flux prediction, neutrino interaction model, and detector effects are included. DUNE will resolve the neutrino mass ordering to a precision of 5σ, for all δCP values, after 2 years of running with the nominal detector design and beam configuration. It has the potential to observe charge-parity violation in the neutrino sector to a precision of 3σ (5σ) after an exposure of 5 (10) years, for 50% of all δCP values. It will also make precise measurements of other parameters governing long-baseline neutrino oscillation, and after an exposure of 15 years will achieve a similar sensitivity to sin 22 θ13 to current reactor experiments. © 2020, The Author(s).

Published
2020

19. Ultrastructural Characterization of Stem Cell-Derived Replacement Vestibular Hair Cells Within Ototoxin-Damaged Rat Utricle Explants

Author

Thomas R. Van De Water, Hans Stenlund, Diana Berggren, and Mimmi Werner

Subjects
Special Issue Articles, 0301 basic medicine, Histology, transdifferentiation, Oto-rino-laryngologi, Biology, behavioral disciplines and activities, Hair Cells, Vestibular, 03 medical and health sciences, 0302 clinical medicine, Utricle, mental disorders, morphology, medicine, Animals, support cell, Inner ear, rat, Rats, Wistar, Saccule and Utricle, Ecology, Evolution, Behavior and Systematics, Vestibular Hair Cell, Vestibular system, Tight junction, integumentary system, Stem Cells, Transdifferentiation, Gap junction, utricle, Ototoxicity, Rats, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Otorhinolaryngology, plasticity, regeneration, Cell Transdifferentiation, embryonic structures, sense organs, Gentamicins, Anatomy, Stem cell, vestibular hair cell, Special Issue Full Length Articles, 030217 neurology & neurosurgery, Biotechnology
Abstract

The auditory apparatus of the inner ear does not show turnover of sensory hair cells (HCs) in adult mammals; in contrast, there are many observations supporting low‐level turnover of vestibular HCs within the balance organs of mammalian inner ears. This low‐level renewal of vestibular HCs exists during normal conditions and it is further enhanced after trauma‐induced loss of these HCs. The main process for renewal of HCs within mammalian vestibular epithelia is a conversion/transdifferentiation of existing supporting cells (SCs) into replacement HCs.In earlier studies using long‐term organ cultures of postnatal rat macula utriculi, HC loss induced by gentamicin resulted in an initial substantial decline in HC density followed by a significant increase in the proportion of HCs to SCs indicating the production of replacement HCs. In the present study, using the same model of ototoxic damage to study renewal of vestibular HCs, we focus on the ultrastructural characteristics of SCs undergoing transdifferentiation into new HCs. Our objective was to search for morphological signs of SC plasticity during this process. In the utricular epithelia, we observed immature HCs, which appear to be SCs transdifferentiating into HCs. These bridge SCs have unique morphological features characterized by formation of foot processes, basal accumulation of mitochondria, and an increased amount of connections with nearby SCs. No gap junctions were observed on these transitional cells. The tight junction seals were morphologically intact in both control and gentamicin‐exposed explants. Anat Rec, 303:506–515, 2020. © 2019 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.

Published
2020

20. Volume III DUNE far detector technical coordination

Author

Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. and Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. and Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V and Autiero, D. Azfar, F. Back, H. Back, J. J. Backhouse, C. and Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. and Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G. and Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. and Barros, N. Barrow, J. L. Bashyal, A. Basque, V Bay, F. Bazo Alba, J. Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V Beltramello, O. Belver, D. Benekos, N. Neves, F. Bento Berger, J. and Berkman, S. Bernardini, P. Berner, R. M. Berns, H. and Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. and Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. and Bilki, B. Bishai, M. Bitadze, A. Blake, A. Siffert, B. Blanco Blaszczyk, F. Blazey, G. Blucher, E. and Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. and Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. and Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S. and Boyden, D. Bracinik, J. Braga, D. Brailsford, D. and Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S. J. and Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. and Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. and Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. and Caratelli, D. Carini, G. Carlus, B. Carniti, P. and Terrazas, I. Caro Carranza, H. Castillo, A. Castromonte, C. and Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. and Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. and Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. and Choubey, S. Christensen, A. Christian, D. Christodoulou, G. and Church, E. Clarke, P. Coan, T. E. Cocco, A. G. and Coelho, J. Conley, E. Conrad, J. Convery, M. Corwin, L. and Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadon, I, J. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. and Cussans, D. Dabrowski, M. Da Motta, H. Peres, L. Da Silva and David, Q. Davies, G. S. Davini, S. Dawson, J. De, K. and De Almeida, R. M. Debbins, P. De Bonis, I Decowski, M. and De Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza and Deisting, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. De Mello Neto, J. R. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V De Vries, J. Dharmapalan, R. and Dias, M. Diaz, F. Diaz, J. Di Domizio, S. Di Giulio, L. and Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. Domine, L. and Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. and Dyshkant, A. Eads, M. Edmunds, D. Eisch, J. Emery, S. and Ereditato, A. Escobar, C. Sanchez, L. Escudero Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. and Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. and Fernandez Menendez, P. Ferraro, F. Fields, L. Filkins, A. and Filthaut, F. Fitzpatrick, R. S. Flanagan, W. Fleming, B. and Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. and Franco, D. Freeman, J. Freestone, J. Fried, J. and Friedland, A. Fuess, S. Furic, I Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V and Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. and Gao, S. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. and Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I Girerd, C. Giri, A. Gnani, D. Gogota, O. Gold, M. and Gollapinni, S. Gollwitzer, K. Gomes, R. A. Gomez Bermeo, L. and Gomez Fajardo, L. S. Gonnella, F. Gonzalez-Cuevas, J. and Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. and Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. and Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. and Griffith, C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V Guenette, R. Guglielmi, A. Guo, B. and Guthikonda, K. Gutierrez, R. Guzowski, P. Guzzo, M. M. and Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. and Hamilton, P. Han, J. Harder, K. Harris, D. A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. and Heeger, K. M. Hennessy, K. Henry, S. Hernandez Morquecho, M. and Herner, K. Hertel, L. Hesam, A. S. Hewes, J. and Pichardo, A. Higuera Hill, T. Hillier, S. J. Himmel, A. and Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. Howell, R. and Huang, J. Huang, J. Hugon, J. Iles, G. Iliescu, A. M. and Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. and James, E. Jargowsky, B. Jediny, F. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Joglekar, A. and Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C. and Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I and Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. and Karyotakis, Y. Kasai, S. Kasetti, S. P. Kashur, L. and Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. and Ketchum, W. Kettell, S. Khabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kordosky, M. Kosc, T. Kose, U. Kostelecky, V Kothekar, K. Krennrich, F. Kreslo, I Kudenko, Y. and Kudryavtsev, V Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V Kutter, T. Lambert, A. Lande, K. Lane, C. E. Lang, K. Langford, T. Lasorak, P. Last, D. and Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G. Lehmann and Lehnert, R. de Oliveira, M. Leigui Leitner, M. Leyton, M. and Li, L. Li, S. Li, S. Li, T. Li, Y. Liao, H. and Lin, C. Lin, S. Lister, A. Littlejohn, B. R. Liu, J. and Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I Long, K. and Loo, K. Lorca, D. Lord, T. LoSecco, J. Louis, W. C. and Luk, K. Luo, X. Lurkin, N. Lux, T. Luzio, V. P. and MacFarland, D. Machado, A. Machado, P. Macias, C. and Macier, J. Maddalena, A. Madigan, P. Magill, S. Mahn, K. and Maio, A. Maloney, J. A. Mandrioli, G. Maneira, J. C. and Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique Marchionni, A. Marciano, W. Marfatia, D. and Mariani, C. Maricic, J. Marinho, F. Marino, A. D. and Marshak, M. Marshall, C. Marshall, J. Marteau, J. and Martin-Albo, J. Martinez, N. Caicedo, D. A. Martinez and Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. and Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. McNab, A. and Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. and Menary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, M. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. Mishra, S. Mislivec, A. Mladenov, D. Mocioiu, I Moffat, K. Moggi, N. Mohanta, R. and Mohayai, T. A. Mokhov, N. Molina, J. A. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. and Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. and Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. Necib, L. and Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. and Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V Papadimitriou, V and Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V Peeters, S. J. Penichot, Y. Pennacchio, E. and Penzo, A. Peres, O. L. Perry, J. Pershey, D. Pessina, G. and Petrillo, G. Petta, C. Petti, R. Piastra, F. and Pickering, L. Pietropaolo, F. Pillow, J. Plunkett, R. and Poling, R. Pons, X. Poonthottathil, N. Pordes, S. and Potekhin, M. Potenza, R. Potukuchi, V, B. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. and Pugnere, D. Qi, K. Qian, X. Raaf, J. Raboanary, R. and Radeka, V Rademacker, J. Radics, B. Rafique, A. and Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I and Rakotondramanana, H. Rakotondravohitra, L. Ramachers, Y. and Rameika, R. Delgado, M. Ramirez Ramson, B. Rappoldi, A. and Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J. and Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. and Reichenbacher, J. Reitzner, S. D. Renshaw, A. Rescia, S. and Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. and Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. and Rodrigues, P. Alonso, M. Rodriguez Rondon, J. Rodriguez and Roeth, A. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. and Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. and Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. and Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M. and Sanders, D. A. Sankey, D. Santana, S. Santos-Maldonado, M. and Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I and Savage, G. Savinov, V Scaramelli, A. Scarff, A. and Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. and Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. and Sensenig, J. Seong, I Sergi, A. Sergiampietri, F. and Sgalaberna, D. Shaevitz, M. Shafaq, S. Shamma, M. and Sharma, H. R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V Sipos, R. Sippach, F. Sirri, G. Sitraka, A. and Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. and Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M. Soares Sobel, H. Soderberg, M. Solano Salinas, C. J. and Soldner-Rembold, S. Solomey, N. Solovov, V Sondheim, W. E. and Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. and Spagliardi, F. Spanu, M. Spitz, J. Spooner, N. J. and Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H. Stewart, J. Stillwell, B. Stock, J. Stocker, F. and Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V Suter, L. Sutera, C. Svoboda, R. Szczerbinska, B. Szelc, A. Talaga, R. and Tanaka, H. Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. Tonazzo, A. Torti, M. Tortola, M. and Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, W. H. Tsai, Y. T. Tsamalaidze, Z. and Tsang, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, M. Uchida, M. A. Urheim, J. Usher, T. and Vagins, M. Vahle, P. Valdiviesso, G. Valencia, E. and Vallari, Z. Valle, J. W. Vallecorsa, S. Van Berg, R. Van de Water, R. G. Forero, D. Vanegas Varanini, F. Vargas, D. and Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M. A. Verzocchi, M. de Souza, H. Vieira Vignoli, C. Vilela, C. Viren, B. and Vrba, T. Wachala, T. Waldron, V, A. Wallbank, M. and Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. and Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M. R. White, A. Whitehead, L. H. and Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wolcott, J. Wongjirad, T. and Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. and Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. and Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. and Zucchelli, S. Zuklin, J. Zutshi, V Zwaska, R. DUNE Collaboration

Published
2020

21. A Regenerative Medicine Approach to the Treatment of Hearing, Balance, and Olfactory Disorders: What Is in the Future for Otolaryngology?

Author

Thomas R. Van De Water

Subjects
0301 basic medicine, Histology, Genetic enhancement, Bioinformatics, Regenerative Medicine, Regenerative medicine, 03 medical and health sciences, Olfaction Disorders, Otolaryngology, 0302 clinical medicine, Genome editing, Medicine, CRISPR, Humans, Progenitor cell, Zebrafish, Hearing Disorders, Ecology, Evolution, Behavior and Systematics, biology, business.industry, Cas9, biology.organism_classification, 030104 developmental biology, Vestibular Diseases, Anatomy, Stem cell, business, 030217 neurology & neurosurgery, Biotechnology
Abstract

Regenerative medicine is being applied to many fields of medicine and is now starting to be considered and developed for application to treat hearing, balance, olfaction, and voice disorders. This special issue of the Anatomical Record with a series of over 20 papers covers many aspects of gene and stem cell therapies as they are developed for clinical applications in both in vitro and in vivo laboratory studies. These studies cover a wide range of approaches from gene editing in zebrafish with the latest technology (i.e., CRISPR/Cas9) to the isolation of human inner ear progenitor cells, to tracking transplanted human umbilical cord stem cells in mini pigs, to the in vitro building of graft tissues to repair tracheal defects with adipose tissue-derived stem cells. Anat Rec, 303:385-389, 2020. © 2019 American Association for Anatomy.

Published
2019

22. Comparison of packing material in an animal model of middle ear trauma

Author

Daniel A. Carlton, Thomas R. Van De Water, Simon I. Angeli, Isabel Bueno, Enrique Perez, Ralph Abi Hachem, and Stephen E. Vernon

Subjects
Guinea Pigs, Polyurethanes, Ear, Middle, Random Allocation, 03 medical and health sciences, 0302 clinical medicine, Animal model, Evoked Potentials, Auditory, Brain Stem, otorhinolaryngologic diseases, medicine, Animals, 030223 otorhinolaryngology, Wound Healing, Absorbable gelatin sponge, business.industry, Granulation tissue, Anatomy, medicine.disease, Gelatin Sponge, Absorbable, Disease Models, Animal, Auditory brainstem response, medicine.anatomical_structure, Otorhinolaryngology, 030220 oncology & carcinogenesis, Anesthesia, Middle ear, Otologic Surgical Procedures, sense organs, Foreign body, business, Wound healing
Abstract

Purpose To compare the performance of absorbable gelatin sponge (AGS) with polyurethane foam (PUF) as middle ear packing material after mucosal trauma. Materials and methods Using a randomized, controlled and blinded study design fifteen guinea pigs underwent middle ear surgery with mucosal trauma performed on both ears. One ear was packed with either PUF or AGS while the contralateral ear remained untreated and used as non-packed paired controls. Auditory brainstem response (ABR) thresholds were measured pre-operatively and repeated at 1, 2, and 6 weeks postoperatively. Histological analysis of middle ear mucosa was done in each group to evaluate the inflammatory reaction and wound healing. Another eighteen animals underwent middle ear wounding and packing in one ear while the contralateral ear was left undisturbed as control. Twelve guinea pigs were euthanized at 2 weeks postoperatively, and six were euthanized at 3 days post-operatively. Mucosal samples were collected for analysis of TGF-β1 levels by enzyme-linked immunosorbent assay. Results ABR recordings demonstrate that threshold level changes from baseline were minor in PUF packed and control ears. Threshold levels were higher in the AGS packed ears compared with both control and PUF packed ears for low frequency stimuli. Histological analysis showed persistence of packing material at 6 weeks postoperatively, inflammation, granulation tissue formation, foreign body reaction and neo-osteogenesis in both AGS and PUF groups. TGF-β1 protein levels did not differ between groups. Conclusion PUF and AGS packing cause inflammation and neo-osteogenesis in the middle ear following wounding of the mucosa and packing.

Published
2016
Full Text
View/download PDF

23. Laminin-coated electrodes improve cochlear implant function and post-insertion neuronal survival

Author

Olena Bracho, Juan A. Chiossone, Mir R. Anwar, Esperanza Bas, Christine T. Dinh, Thomas R. Van De Water, and Stefania Goncalves

Subjects
0301 basic medicine, Male, Neurite, Cell Survival, medicine.medical_treatment, Schwann cell proliferation, Extracellular matrix, Rats, Sprague-Dawley, 03 medical and health sciences, Random Allocation, 0302 clinical medicine, Laminin, Cochlear implant, Rats, Inbred BN, otorhinolaryngologic diseases, medicine, Electrode array, Animals, Organ of Corti, Spiral ganglion, Cells, Cultured, Neurons, biology, Chemistry, General Neuroscience, Cell biology, Electrodes, Implanted, Rats, 030104 developmental biology, Auditory brainstem response, medicine.anatomical_structure, Cochlear Implants, Animals, Newborn, biology.protein, sense organs, 030217 neurology & neurosurgery
Abstract

The benefits of Cochlear implant (CI) technology depend among other factors on the proximity of the electrode array to the spiral ganglion neurons. Laminin, a component of the extracellular matrix, regulates Schwann cell proliferation and survival as well as reorganization of actin fibers within their cytoskeleton, which is necessary for myelination of peripheral axons. In this study we explore the effectiveness of laminin-coated electrodes in promoting neuritic outgrowth from auditory neurons towards the electrode array and the ability to reduce acoustic and electric auditory brainstem response (i.e. aABR and eABR) thresholds. In vitro: Schwann cells and neurites are attracted towards laminin-coated surfaces with longer neuritic processes in laminin-coated dishes compared to uncoated dishes. In vivo: Animals implanted with laminin-coated electrodes experience significant decreases in eABR and aABR thresholds at selected frequencies compared to the results from the uncoated electrodes group. At 1 month post implantation there were a greater number of spiral ganglion neurons and neuritic processes projecting into the scala tympani of animals implanted with laminin-coated electrodes compared to animals with uncoated electrodes. These data suggest that Schwann cells are attracted towards laminin-coated electrodes and promote neuritic outgrowth/ guidance and promote the survival of spiral ganglion neurons following electrode insertion trauma.

Published
2018

24. FRI0529 Preoperative pain seems to modify the effect of radiographic osteoarthiritis severity on postoperative pain and function 1 year after total knee arthroplasty

Author

Herman H Kaptijn, Claudia S. Leichtenberg, M. Gademan, T. P. M. Vliet Vlieland, H. Kroon, R. van de Water, R.G.H.H. Nelissen, R. Onstenk, and S.H.M. Verdegaal

Subjects
medicine.medical_specialty, Preoperative pain, business.industry, Radiography, Postoperative pain, Confounding, Arthritis, Osteoarthritis, medicine.disease, Internal medicine, Orthopedic surgery, medicine, business, Cohort study
Abstract

Background Radiographic osteoarthritis (OA) severity and pain play an important role in the indication for total knee arthroplasty (TKA). It is however unkonw whether preoperative self-reported clinical pain modifies the effect of radiographic OA severity on postoperative pain and function in OA patients after TKA. Objectives To investigate whether preoperative self-reported clinical pain modified the effect of radiographic OA severity on postoperative pain and function in OA patients 1 year after TKA. Methods Data from the Longitudinal Leiden Orthopaedics Outcomes of Osteoarthritis Study (LOAS), a multicentre cohort study on outcomes after TKA were used. Radiographic OA severity was assessed with the Kellgren and Lawrence (KL) score (0–4). Pain and function were evaluated with the Knee Injury and Osteoarthritis Outcome Score (KOOS). After adjustment for confounders (BMI, age, gender and Mental Health Component Scores from the Short Form-12), multivariate linear regression analyses with an interaction term between KL-score and preoperative pain were performed. Results 560 patients were included. Both KL-score and preoperative pain were associated with postoperative pain (β:6.1, 95% CI: 1.7–10.5 and β:0.4, 95% CI 0.1–0.7)) and function (β:8.0, 95% CI: 3.7–12.3 and β 0.5, 95% CI 0.2–0.8). A trend towards effect modification of preoperative pain on the association between KL-score and postoperative pain (β −0.1, 95% CI −0.2–0.0) and function (β −0.1, 95% CI −0.2–0.0) was found indicating that effect of preoperative pain on postoperative pain and function seems to become less important when more severe radiographic severity is present. Conclusions Patients with less preoperative pain and higher KL grades have better function and pain outcomes 12 months after TKA. However preoperative pain seems less importance in patients with more severe radiographic OA. Acknowledgements This study was supported by the Dutch Arthritis Association [grant number LLP13]. Disclosure of Interest None declared

Published
2018
Full Text
View/download PDF

25. Isolation and Characterization of Mammalian Otic Progenitor Cells that Can Differentiate into Both Sensory Epithelial and Neuronal Cell Lineages

Author

Thomas R. Van De Water, Takeshi Nishio, Nobuo Kato, Kiichi Hirota, Kei Tashiro, Miyahiko Murata, Juichi Ito, Ken Kojima, Saburo Kawaguchi, Azel Zine, and Akiko T. Nishida

Subjects
0301 basic medicine, Homeobox protein NANOG, Cell type, Histology, Biology, Stem cell marker, Nestin, 03 medical and health sciences, 0302 clinical medicine, Hair Cells, Auditory, medicine, Basic Helix-Loop-Helix Transcription Factors, Animals, Cell Lineage, Progenitor cell, Rats, Wistar, Ecology, Evolution, Behavior and Systematics, NeuroD, Neurons, Stem Cells, Cell Differentiation, Nanog Homeobox Protein, Embryonic stem cell, Cell biology, Rats, 030104 developmental biology, medicine.anatomical_structure, Cell culture, Ear, Inner, Myosin VIIa, sense organs, Hair cell, Anatomy, 030217 neurology & neurosurgery, Biotechnology
Abstract

The mammalian inner ear mediates hearing and balance and during development generates both cochleo-vestibular ganglion neurons and sensory epithelial receptor cells, that is, hair cells and support cells. Cell marking experiments have shown that both hair cells and support cells can originate from a common progenitor. Here, we demonstrate the lineage potential of individual otic epithelial cell clones using three cell lines established by a combination of limiting dilution and gene-marking techniques from an embryonic day 12 (E12) rat otocyst. Cell-type specific marker analyses of these clonal lines under proliferation and differentiation culture conditions demonstrate that during differentiation immature cell markers (Nanog and Nestin) were downregulated and hair cell (Myosin VIIa and Math1), support cell (p27Kip1 and cytokeratin) and neuronal cell (NF-H and NeuroD) markers were upregulated. Our results suggest that the otic epithelium of the E12 mammalian inner ear possess multipotent progenitor cells able to generate cell types of both sensory epithelial and neural cell lineages when cultured under a differentiation culture condition. Understanding the molecular mechanisms of proliferation and differentiation of multipotent otic progenitor cells may provide insights that could contribute to the development of a novel cell therapy with a potential to initiate or stimulate the sensorineural repair of damaged inner ear sensory receptors. Anat Rec, 303:451-460, 2020. © 2019 American Association for Anatomy.

Published
2018

26. Dexamethasone Protects Against Radiation-induced Loss of Auditory Hair Cells In Vitro

Author

Thomas R. Van De Water, Nagy Elsayyad, Stefania Goncalves, Perry Johnson, John Dinh, Esperanza Bas, Kyle R. Padgett, Simon I. Angeli, Adrien A. Eshraghi, Si Chen, Christine T. Dinh, and Fred F. Telischi

Subjects
Hearing Loss, Sensorineural, Anti-Inflammatory Agents, Apoptosis, medicine.disease_cause, Dexamethasone, Andrology, Organ Culture Techniques, Ototoxicity, In vivo, Hair Cells, Auditory, In Situ Nick-End Labeling, Animals, Medicine, Organ of Corti, Microscopy, Confocal, TUNEL assay, business.industry, medicine.disease, Sensory Systems, In vitro, Rats, Disease Models, Animal, Oxidative Stress, Radiation Injuries, Experimental, medicine.anatomical_structure, Otorhinolaryngology, Neurology (clinical), business, Oxidative stress, medicine.drug
Abstract

Hypothesis: Dexamethasone (DXM) protects against radiation-induced loss of auditory hair cells (HCs) in rat organ of Corti (OC) explants by reducing levels of oxidative stress and apoptosis. Background: Radiation-induced sensorineural hearing loss (HL) is progressive, dose-dependent, and irreversible. Currently, there are no preventative therapeutic modalities for radiation-induced HL. DXM is a synthetic steroid that can potentially target many of the pathways involved in radiation-induced ototoxicity. Methods: Whole OC explants were dissected from 3-day-old rat cochleae exposed to specific dosages of single-fraction radiation (0, 2, 5, 10, or 20 Gy), were either untreated or treated with DXM (75, 150, 300 μg/mL), and then cultured for 48 or 96 hours. Confocal microscopy for oxidative stress (CellRox, 48 h) and apoptosis (TUNEL assay, 96 h) and fluorescent microscopy for viable HC counts (fluorescein isothiocyanate-phalloidin, 96 h) were performed. Analysis of variance and Tukey post hoc testing were used for statistical analysis. Results: Radiation exposure initiated dose-dependent losses of inner and outer HCs, predominantly in the basal turns of the OC explants. DXM protected against radiation-induced HC losses in a dose-dependent manner. DXM significantly reduced levels of oxidative stress and apoptosis in radiation-injured OC explants (p Conclusions: Radiation-initiated HC losses were dose-dependent in OC explants. DXM treatment protected explant HCs against radiation-initiated losses by decreasing the levels of oxidative stress and apoptosis. DXM may potentially be a therapeutic modality for preventing radiation-induced HL; further in vivo studies are necessary.

Published
2015
Full Text
View/download PDF

27. Dexamethasone Protects Against Apoptotic Cell Death of Cisplatin-exposed Auditory Hair Cells In Vitro

Author

John Dinh, Simon I. Angeli, Christine T. Dinh, Esperanza Bas, Stefania Goncalves, Fred F. Telischi, Adrien A. Eshraghi, Si Chen, and Thomas R. Van De Water

Subjects
Pathology, medicine.medical_specialty, Cell Survival, Antineoplastic Agents, Apoptosis, In Vitro Techniques, medicine.disease_cause, Dexamethasone, Rats, Sprague-Dawley, Andrology, Ototoxicity, Hair Cells, Auditory, In Situ Nick-End Labeling, Animals, Medicine, Glucocorticoids, Organ of Corti, Cochlea, Cisplatin, Microscopy, Confocal, TUNEL assay, business.industry, NADPH Oxidases, medicine.disease, Sensory Systems, Rats, Oxidative Stress, medicine.anatomical_structure, Otorhinolaryngology, Neurology (clinical), business, Oxidative stress, medicine.drug
Abstract

HYPOTHESIS Dexamethasone (DXM) protects against cisplatin-induced auditory hair cell (HC) loss in rat organ of Corti (OC) explants in vitro by reducing levels of oxidative stress and NADPH-Oxidase-3 (NOX-3). BACKGROUND Intratympanic DXM has demonstrated protective effects against cisplatin-induced hearing loss in a few animal studies and one clinical trial. However, levels of protection with intratympanic DXM vary significantly between studies, which may not be a result of the intrinsic properties of DXM but rather reflect the diffusion of DXM into the cochlea. The molecular mechanisms and degree of DXM protection against cisplatin ototoxicity are currently unknown. METHODS OC explants from 3-day-old rats were cultured with no treatment or various concentrations of cisplatin (2, 5, or 10 μM) and DXM (75, 150, or 300 μg/mL) in vitro. HC viability and TUNEL assay were performed after 72 hours in vitro and levels of oxidative stress and NOX-3 were evaluated with confocal microscopy after 48 hours in vitro. Analysis of variance with Tukey's post hoc testing was performed. RESULTS Cisplatin initiated dose-dependent losses of outer HCs (OHCs) in the basal turns of exposed explants (p

Published
2015
Full Text
View/download PDF

28. Mechanisms of programmed cell death signaling in hair cells and support cells post-electrode insertion trauma

Author

Helio Rodrigues, Chhavi Gupta, Thomas R. Van De Water, Carolyn Garnham, Adrien A. Eshraghi, Jonathan Roell, Jeenu Mittal, Mateo Guardiola, and Dustin Lang

Subjects
Programmed cell death, Pathology, medicine.medical_specialty, Time Factors, Necrosis, medicine.medical_treatment, Guinea Pigs, Apoptosis, Electrode insertion, Cochlear implant, Hair Cells, Auditory, otorhinolaryngologic diseases, medicine, Animals, Aldehydes, integumentary system, Caspase 3, business.industry, JNK Mitogen-Activated Protein Kinases, Labyrinth Supporting Cells, General Medicine, Anatomy, Sensory cell, Cochlear Implantation, Disease Models, Animal, Oxidative Stress, Cochlear Implants, medicine.anatomical_structure, Otorhinolaryngology, Organ of Corti, sense organs, medicine.symptom, business, Post implantation, Immunostaining, Signal Transduction
Abstract

Programmed cell death (PCD) initially starts in the support cells (SCs) after electrode insertion trauma (EIT), followed by PCD in hair cells (HCs). Activation of caspase-3 was observed only in SCs. Protecting both SCs and HCs with selective otoprotective drugs at an early stage post implantation may help to preserve residual hearing.Cochlear implant EIT can initiate sensory cell losses via necrosis and PCD within the organ of Corti, which can lead to a loss of residual hearing. PCD appears to be a major factor in HC loss post-EIT. The current study aimed to: (1) determine the onset of PCD in both SCs and HCs within the traumatized organ of Corti; and (2) identify the molecular mechanisms active within the HCs and SCs that are undergoing PCD.Adult guinea pigs were assigned to one of two groups: (1) EIT and (2) unoperated contralateral ears as controls. Immunostaining of dissected organ of Corti surface preparations for phosphorylated-Jun, cleaved caspase-3, and 4-hydroxy-2,3-nonenal (HNE) were performed at 6, 12, and 24 h post-EIT and for contralateral control ears.At 6 h post-EIT the SCs immunolabeled for the presence of phosphorylated-Jun and activated caspase-3. Phosphorylated p-Jun labeling was observed at 12 h in both the HCs and SCs of middle and basal cochlear turns. Cleaved caspase-3 was not observed in HCs of any cochlear turn at up to 24 h post-EIT. Lipid peroxidation (HNE immunostaining) was first observed at 12 h post-EIT in both the HCs and SCs of the basal turn, and reached the apical turn by 24 h post-EIT.

Published
2015
Full Text
View/download PDF

29. Morphological and morphometric characterization of direct transdifferentiation of support cells into hair cells in ototoxin-exposed neonatal utricular explants

Author

Mimmi Werner, Thomas R. Van De Water, Diana Berggren, Göran Arnoldsson, and Peter Hammarsten

Subjects
Vestibular system, Utricular macula, Time Factors, integumentary system, Transdifferentiation, Cell Count, Anatomy, Biology, Sensory Systems, Organ Culture Techniques, Animals, Newborn, Cell Transdifferentiation, Hair Cells, Auditory, otorhinolaryngologic diseases, medicine, Animals, Gentamicin, sense organs, Gentamicins, Rats, Wistar, Saccule and Utricle, medicine.drug, Explant culture
Abstract

We have studied aminoglycoside-induced vestibular hair-cell renewal using long-term culture of utricular macula explants from 4-day-old rats. Explanted utricles were exposed to 1 mM of gentamicin for 48 h, during 2nd and 3rd days in vitro (DIV), and then recovering in unsupplemented medium. Utricles were harvested at specified time points from the 2nd through the 28th DIV. The cellular events that occurred within hair cell epithelia during the culture period were documented from serial sectioned specimens. Vestibular hair cells (HCs) and supporting cells (SCs) were systematically counted using light microscopy (LM) with the assistance of morphometric software. Ultrastructural observations were made from selected specimens with transmission electron microscopy (TEM). After 7 DIV, i.e. four days after gentamicin exposure, the density of HCs was 11% of the number of HCs observed in non-gentamicin-exposed control explants. At 28 DIV the HC density was 61% of the number of HCs observed in the control group explant specimens. Simultaneously with this increase in HCs there was a corresponding decline in the number of SCs within the epithelium. The proportion of HCs in relation to SCs increased significantly in the gentamicin-exposed explant group during the 5th to the 28th DIV period of culture. There were no significant differences in the volume estimations of the gentamicin-exposed and the control group explants during the observed period of culture. Morphological observations showed that gentamicin exposure induced extensive loss of HCs within the epithelial layer, which retained their intact apical and basal linings. At 7 to 14 DIV (i.e. 3-11 days after gentamicin exposure) a pseudostratified epithelium with multiple layers of disorganized cells was observed. At 21 DIV new HCs were observed that also possessed features resembling SCs. After 28 DIV a new luminal layer of HCs with several layers of SCs located more basally characterized the gentamicin-exposed epithelium. No mitoses were observed within the epithelial layer of any explants. Our conclusion is that direct transdifferentiation of SCs into HCs was the only process contributing to the renewal of HCs after gentamicin exposure in these explants of vestibular inner ear epithelia obtained from the labyrinths of 4-day-old rats.

Published
2015
Full Text
View/download PDF

30. Trauma, Inflammation, Cochlear Implantation Induced Hearing Loss and Otoprotective Strategies to Limit Hair Cell Death and Hearing Loss

Author

Christine T. Dinh, Stefania Goncalves, Esperanza Bas, Enrique Perez, and Thomas R. Van De Water

Subjects
0301 basic medicine, integumentary system, business.industry, Hearing loss, Inflammation, Highly sensitive, Electrode insertion, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Apoptosis, otorhinolaryngologic diseases, Medicine, sense organs, Hair cell, Signal transduction, medicine.symptom, Cochlear implantation, business, Neuroscience, 030217 neurology & neurosurgery
Abstract

Hair cells are highly sensitive units that in response to trauma, inflammation, and cochlear implantation activate different signaling pathways leading to hair cell death and hearing impairment. In this chapter we discuss the most recent literature regarding signaling pathways of hair cell loss, mechanisms and inflammatory responses after noise exposure and electrode insertion, and otoprotective strategies that can limit hair cell death and hearing loss.

Published
2018
Full Text
View/download PDF

31. Otoprotective Properties of Mannitol Against Gentamicin Induced Hair Cell Loss

Author

Thomas R. Van De Water, Adrien A. Eshraghi, John W. Wood, Esperanza Bas, Fred F. Telischi, Yamil Selman, and Chhavi Gupta

Subjects
Interleukin-1beta, Ototoxicity, Hair Cells, Auditory, otorhinolaryngologic diseases, medicine, Animals, Mannitol, Organ of Corti, Cochlea, Tumor Necrosis Factor-alpha, business.industry, Aminoglycoside, Free radical scavenger, medicine.disease, Molecular biology, Sensory Systems, Anti-Bacterial Agents, Rats, medicine.anatomical_structure, Otorhinolaryngology, Cyclooxygenase 2, Receptors, Tumor Necrosis Factor, Type I, Gentamicin, sense organs, Neurology (clinical), Hair cell, Gentamicins, Reactive Oxygen Species, business, medicine.drug
Abstract

Gentamicin is a widely used antibiotic, which causes hearing loss because of destruction of auditory hair cells. Mannitol has been shown to have cytoprotective properties in the cochlea both in vitro and in vivo. Mannitol has been shown to be safe in concentrations up to 100 mM in organ of Corti explants. It is proposed as an otoprotective agent against gentamicin ototoxicity.Organ of Corti were dissected from P-3 rat pups and cultured under the following conditions for 96 hours: 1) control, 2) gentamicin (10 μM for all hair cell count experiments), 3) gentamicin + mannitol 10 mM, 4) gentamicin + mannitol 50 mM, and 5) gentamicin + mannitol 100 mM. The tissues were then fixed and stained, and hair cells were counted for segments of the apex, middle, and basal turns. Quantitative RT-PCR (qRT-PCR) was performed on organ of Corti explant extracted RNA after 24 hours in vitro: 1) control; 2) gentamicin (100 μM for all gene expression and CellRox experiments); 3) gentamicin +mannitol 100 mM; and 4) mannitol 100 mM for tumor necrosis factor-alpha (TNF-α), TNF-α receptor (TNFR1A), interleukin-1 beta (IL-1β) and cyclooxygenase-2 (COX-2). In vitro examination of oxidative stress was performed for the same test groups at 24 hours using CellRox Deep Red assay.Gentamicin induced loss of both inner hair cells and outer hair cells with increasing severity from apex to middle to basal segments (Pearson r = -0.999 for inner hair cells and -0.972 for outer hair cells). Mannitol demonstrated dose-dependent otoprotection of IHCs and outer hair cells (p0.001 for mannitol at 100 mM). CellRox demonstrated increased oxidative stress induced by gentamicin exposure, and this effect was attenuated by treatment of gentamicin-exposed explants with mannitol (p0.05). TNF-α, IL-1β TNFR1A, and COX-2 mRNA levels were upregulated by gentamicin (p0.05). Mannitol treatment of gentamicin explants downregulated the gene expression of the proinflammatory cytokines, but this difference did not achieve significance. Interestingly, in gentamicin-challenged organ of Corti explants, Mannitol upregulated the expression of TNFR1A, but this increase did not achieve significance (p0.05).Gentamicin ototoxicity is increasingly severe from the apex to basal turn of the cochlea. Treatment with mannitol prevents gentamicin-induced hair cell loss in a dose-dependent manner, protecting both IHCs and outer hair cells. Mannitol appears to act as a free radical scavenger to reduce the cytotoxic effects of gentamicin by reducing the level of oxidative stress.

Published
2014
Full Text
View/download PDF

32. The DUNE Far Detector Interim Design Report Volume 1: Physics, Technology and Strategies

Author

Collaboration, D, Abi, B, Acciarri, R, Acero, M, Adamowski, M, Adams, C, Adams, D, Adamson, P, Adinolfi, M, Ahmad, Z, Albright, C, Aliaga Soplin, L, Alion, T, Alonso Monsalve, S, Alrashed, M, Alt, C, Anderson, J, Anderson, K, Andreopoulos, C, Andrews, M, Andrews, R, Ankowski, A, Anthony, J, Antonello, M, Antonova, M, Antusch, S, Aranda Fernandez, A, Ariga, A, Ariga, T, Aristizabal Sierra, D, Arrieta Diaz, E, Asaadi, J, Ascencio, M, Asner, D, Athar, M, Auger, M, Aurisano, A, Aushev, V, Autiero, D, Azfar, F, Back, A, Back, H, Back, J, Backhouse, C, Baesso, P, Bagby, L, Bai, X, Baird, M, Balantekin, B, Balasubramanian, S, Baller, B, Ballett, P, Balleyguier, L, Bambah, B, Band, H, Bansal, M, Bansal, S, Barenboim, G, Barker, G, Barnes, C, Barr, G, Barranco Monarca, J, Barros, N, Barrow, J, Bashyal, A, Basque, V, Bass, M, Bay, F, Bays, K, Bazo, J, Beacom, J, Bechetoille, E, Behera, B, Bellantoni, L, Bellettini, G, Bellini, V, Beltramello, O, Belver, D, Benekos, N, Benetti, P, Bercellie, A, Berman, E, Bernardini, P, Berner, R, Berns, H, Bernstein, R, Bertolucci, S, Betancourt, M, Bhatnagar, V, Bhattacharjee, M, Bhuyan, B, Biagi, S, Bian, J, Biery, K, Bilki, B, Bishai, M, Bitadze, A, Blackburn, T, Blake, A, Blanco Siffert, B, Blaszczyk, F, Blaufuss, E, Blazey, G, Blennow, M, Blucher, E, Bocean, V, Boffelli, F, Boissevain, J, Bolognesi, S, Bolton, T, Bonesini, M, Boone, T, Booth, A, Booth, C, Bordoni, S, Borkum, A, Boschi, T, Bour, P, Bourguille, B, Boyd, S, Boyden, D, Bracinik, J, Brailsford, D, Brandt, A, Bremer, J, Brice, S, Bromberg, C, Brooijmans, G, Brooke, J, Brown, G, Buchanan, N, Budd, H, de Holanda, P, Cai, T, Caiulo, D, Calafiura, P, Calatayud, A, Calcutt, J, Callahan, C, Calligarich, E, Calvo, E, Camilleri, L, Caminata, A, Campanelli, M, Cancelo, G, Cankocak, K, Cantini, C, Caratelli, D, Carlus, B, Carneiro, M, Caro Terrazas, I, Carroll, T, Carvallo, M, Cascella, M, Castromonte, C, Catano-Mur, E, Cavalli-Sforza, M, Cavanna, F, Cazzato, E, Centro, S, Cerati, G, Cervelli, A, Cervera Villanueva, A, Cervi, T, Chalifour, M, Chappuis, A, Chatterjee, A, Chattopadhyay, S, Chaves, J, Chen, H, Chen, M, Chen, S, Cherdack, D, Chi, C, Childress, S, Cho, K, Choubey, S, Choudhary, B, Christensen, A, Christian, D, Christodoulou, G, Christofferson, C, Church, E, Clarke, P, Coan, T, Cocco, A, Collin, G, Conley, E, Conrad, J, Convery, M, Corey, R, Corwin, L, Cotte, P, Cremonesi, L, Crespo-Anadón, J, Creus Prats, J, Cristaldo, E, Crivelli, P, Cronin-Hennessy, D, Crowley, C, Cuesta, C, Curioni, A, Cussans, D, Dabrowski, M, Dale, D, Da Motta, H, Davenne, T, Davenport, E, Davies, G, Davies, J, Davini, S, Dawson, J, De, K, Decowski, M, Dedin Neto, P, de Icaza Astiz, I, Delbart, A, Delepine, D, Delgado, M, Dell, A, de Mello Neto, J, Demuth, D, Deng, Z, Dennis, S, Densham, C, De Bonis, I, De Gouvêa, A, De Jong, P, De Lurgio, P, De Rijck, S, De Roeck, A, de Vries, J, Dharmapalan, R, Dhingra, N, Diamantopoulou, M, Diaz, F, Díaz, J, Diaz Bautista, G, Ding, P, Distefano, C, Diwan, M, Di Domizio, S, Di Giulio, L, Di Luise, S, Djurcic, Z, Doizon, F, Dokania, N, Dolinski, M, Dong, R, dos Anjos, J, Douglas, D, Drake, G, Duchesneau, D, Duffy, K, Dung, B, Dutta, D, Duvernois, M, Duyang, H, Dvornikov, O, Dwyer, D, Dye, S, Dyshkant, A, Dytman, S, Eads, M, Eberly, B, Edmunds, D, Eisch, J, Elagin, A, Elliott, S, Ellsworth, W, Elnimr, M, Emery, S, Eno, S, Ereditato, A, Escobar, C, Escudero Sanchez, L, Evans, J, Ezeribe, A, Fahey, K, Falcone, A, Falk, L, Farbin, A, Farnese, C, Farzan, Y, Fasoli, M, Fava, A, Felix, J, Fernandez-Martinez, E, Fernandez Menendez, P, Ferraro, F, Feyzi, F, Fields, L, Filkins, A, Filthaut, F, Finch, A, Fischer, O, Fitton, M, Fitzpatrick, R, Flanagan, W, Fleming, B, Flight, R, Forest, T, Fowler, J, Fox, W, Franc, J, Francis, K, Franchini, P, Franco, D, Freeman, J, Freestone, J, Fried, J, Friedland, A, Fuess, S, Furic, I, Furmanski, A, Gago, A, Gallagher, H, Gallego-Ros, A, Galymov, V, Gamberini, E, Gambetta, S, Gamble, T, Gandhi, R, Gandrajula, R, Gao, S, Garcia-Gamez, D, Gardiner, S, Gastler, D, Gehrlein, J, Gelli, B, Gendotti, A, Ghorbani-Moghaddam, Z, Ghosh, A, Gibin, D, Gil-Botella, I, Girerd, C, Giri, A, Glavin, S, Goeldi, D, Gogota, O, Gold, M, Gollapinni, S, Gollwitzer, K, Gomes, R, Gomez, L, Gomez Bermeo, L, Gomez Cadenas, J, Gong, H, Gonnella, F, Gonzalez-Cuevas, J, Goodman, M, Goodwin, O, Gorbunov, D, Goswami, S, Goudzovski, E, Grace, C, Graf, N, Graham, M, Gramellini, E, Gran, R, Grant, A, Grant, C, Grant, N, Greco, V, Green, S, Greenlee, H, Greenler, L, Greenwood, M, Greer, J, Griffith, W, Groh, M, Grudzinski, J, Grzelak, K, Guanghua, G, Guardincerri, E, Guarino, V, Guedes, G, Guenette, R, Guglielmi, A, Guo, B, Gupta, S, Gupta, V, Guthikonda, K, Gutierrez, R, Guzowski, P, Guzzo, M, Habig, A, Hackenburg, R, Hackenburg, A, Hackett, B, Hadavand, H, Haenni, R, Hahn, A, Haigh, J, Haines, T, Haiston, J, Hamernik, T, Hamilton, P, Han, J, Handler, T, Hans, S, Harris, D, Hartnell, J, Hasegawa, T, Hatcher, R, Hatzikoutelis, A, Hays, S, Hazen, E, Headley, M, Heavey, A, Heegerv, K, Heise, J, Hennessy, K, Henry, S, Hernandez, A, Hernandez-Garcia, J, Herner, K, Hewes, J, Hignight, J, Higuera, A, Hill, T, Hillier, S, Himmel, A, Hohl, C, Holin, A, Hoppe, E, Horikawa, S, Horton-Smith, G, Hostert, M, Hourlier, A, Howard, B, Howell, R, Huang, J, Hugon, J, Hurh, P, Hylen, J, Illingworth, R, Insler, J, Introzzi, G, Ioannisian, A, Izmaylov, A, Jaffe, D, James, C, James, E, Jang, C, Jediny, F, Jeong, Y, Jhingan, A, Ji, W, Jipa, A, Jiménez, S, Johnson, C, Johnson, M, Johnson, R, Johnstone, J, Jones, B, Jones, S, Joshi, J, Jostlein, H, Jung, C, Junk, T, Kaboth, A, Kadenko, I, Kamiya, F, Kamyshkov, Y, Karagiorgi, G, Karasavvas, D, Karyotakis, Y, Kasai, S, Kasetti, S, Kaur, K, Kayser, B, Kazaryan, N, Kearns, E, Keener, P, Kemp, E, Kendziora, C, Ketchum, W, Kettell, S, Khabibullin, M, Khotjantsev, A, Kim, D, Kirby, B, Kirby, M, Klein, J, Ko, Y, Kobilarcik, T, Kocaman, B, Koerner, L, Kohn, S, Koizumi, G, Koller, P, Kopylov, A, Kordosky, M, Kormos, L, Kosc, T, Kose, U, Kostelecký, V, Kothekar, K, Kramer, M, Krennrich, F, Kreslo, I, Kriesel, K, Kropp, W, Kudenko, Y, Kudryavtsev, V, Kulagin, S, Kumar, J, Kumar, L, Kumar, A, Kumbhare, S, Kuruppu, C, Kus, V, Kutter, T, Lazur, R, Lande, K, Lane, C, Lang, K, Langford, T, Lanni, F, Lasorak, P, Last, D, Lastoria, C, Laundrie, A, Lazanu, I, Le, T, Learned, J, Lebrun, P, Lee, D, Lehmann Miotto, G, Leigui de Oliveira, M, Li, Q, Li, S, Li, X, Li, Y, Li, Z, Liao, H, Lin, S, Lin, C, Linehan, R, Linhart, V, Link, J, Liptak, Z, Lissauer, D, Littenberg, L, Littlejohn, B, Liu, J, Liu, T, Lomonaco, L, Losecco, J, Lockwitz, S, Lockyer, N, Loew, T, Lokajicek, M, Long, K, Loo, K, Lopez, J, Lorca, D, Lord, T, Losada, M, Louis, W, Luethi, M, Luk, K, Lundin, T, Luo, X, Lurkin, N, Lux, T, Luzio, V, Lykken, J, Maalampi, J, Maclellan, R, Machado, A, Machado, P, Macias, C, Macier, J, Madigan, P, Magill, S, Mahler, G, Mahn, K, Malek, M, Maloney, J, Mammoliti, F, Mandal, S, Mandrioli, G, Manenti, L, Manly, S, Mann, A, Marchionni, A, Marciano, W, Marcocci, S, Marfatia, D, Mariani, C, Maricic, J, Marinho, F, Marino, A, Marshak, M, Marshall, C, Marshall, J, Marteau, J, Martin-Albo, J, Martinez, D, Martinez, N, Martinez, H, Mason, K, Mastbaum, A, Masud, M, Mathez, H, Matsuno, S, Matthews, J, Mauger, C, Mauri, N, Mavrokoridis, K, Mazza, R, Mazzacane, A, Mazzucato, E, Mccauley, N, Mccluskey, E, Mcconkey, N, Mcdonald, K, Mcfarland, K, Mcgivern, C, Mcgowan, A, Mcgrew, C, Mckeown, R, Mcnab, A, Mcnulty, D, Mctaggart, R, Meddage, V, Mefodiev, A, Mehta, P, Mei, D, Mena, O, Menary, S, Mendez, H, Mendez, D, Menegolli, A, Meng, G, Messier, M, Metcalf, W, Mewes, M, Meyer, H, Miao, T, Migenda, J, Milincic, R, Miller, J, Miller, W, Mills, J, Milne, C, Mineev, O, Miranda, O, Mishra, C, Mishra, S, Mislivec, A, Mitrica, B, Mladenov, D, Mocioiu, I, Moffat, K, Moggi, N, Mohanta, R, Mokhov, N, Molina, J, Molina Bueno, L, Montanari, A, Montanari, C, Montanari, D, Montano Zetina, L, Moon, J, Mooney, M, Moore, C, Moreno, D, Morgan, B, Moroni, G, Morris, C, Morse, W, Mossey, C, Moura, C, Mousseau, J, Mualem, L, Muether, M, Mufson, S, Muheim, F, Muramatsu, H, Murphy, S, Musser, J, Nachtman, J, Nalbandyan, M, Nandakumar, R, Naples, D, Narita, S, Navarro, G, Navarro, J, Navas-Nicolás, D, Nayak, N, Nebot-Guinot, M, Needham, M, Negishi, K, Nelson, J, Nessi, M, Newbold, D, Newcomer, M, Nichol, R, Nicholls, T, Niner, E, Norman, A, Norris, B, Norris, J, Novella, P, Nowak, E, Nowak, J, Nunes, M, O'Keeffe, H, Oberling, M, Olivares Del Campo, A, Olivier, A, Onel, Y, Onishchuk, Y, Ovsjannikova, T, Ozturk, S, Pagani, L, Pakvasa, S, Palamara, O, Paley, J, Pallavicini, M, Palomares, C, Palomino, J, Pantic, E, Paolo, A, Paolone, V, Papadimitriou, V, Papaleo, R, Paramesvaran, S, Park, J, Parke, S, Parsa, Z, Pascoli, S, Pasternak, J, Pater, J, Patrizii, L, Patterson, R, Patton, S, Patzak, T, Paudel, A, Paulos, B, Paulucci, L, Pavlovic, Z, Pawloski, G, Payam, P, Payne, D, Pec, V, Peeters, S, Pennacchio, E, Penzo, A, Perdue, G, Peres, O, Periale, L, Petridis, K, Petrillo, G, Petti, R, Picchi, P, Pickering, L, Pietropaolo, F, Pillow, J, Plonski, P, Plunkett, R, Poling, R, Pons, X, Poonthottathil, N, Popovic, M, Pordes, R, Pordes, S, Potekhin, M, Potenza, R, Potukuchi, B, Poudel, S, Pozimski, J, Pozzato, M, Prakasj, T, Preece, R, Prokofiev, O, Pruthi, N, Przewlocki, P, Psihas, F, Pugnëre, D, Pushka, D, Qi, K, Qian, X, Raaf, J, Raboanary, R, Radeka, V, Rademacker, J, Radescu, V, Radics, B, Radovic, A, Rafique, A, Rajaoalisoa, M, Rakhno, I, Rakotondramanana, H, Rakotondravohitra, L, Ramachers, Y, Rameika, R, Ramirez Delgado, M, Ramsey, J, Ramson, B, Rappoldi, A, Raselli, G, Ratoff, P, Ravat, S, Ravinez, O, Razafinime, H, Rebel, B, Redondo, D, Regenfus, C, Reggiani-Guzzo, M, Rehak, T, Reichenbacher, J, Reitzner, D, Reno, M, Renshaw, A, Rescia, S, Resnati, F, Reynolds, A, Riccobene, G, Rice, L, Rielage, K, Riesselmann, K, Rigaut, Y, Rivera, D, Rochester, L, Roda, M, Rodrigues, P, Rodriguez Alonso, M, Roe, B, Roeth, A, Roser, R, Ross-Lonergan, M, Rossella, M, Rout, J, Roy, S, Rubbia, A, Rubbia, C, Rucinski, R, Russell, B, Russell, J, Ruterbories, D, Vagins, M, Saakyan, R, Sahu, N, Sala, P, Salukvadze, G, Samios, N, Sanchez, F, Sanchez, M, Sandoval, C, Sands, B, Sankar, S, Santana, S, Santos, L, Santucci, G, Saoulidou, N, Sapienza, P, Sarasty, C, Sarcevic, I, Savage, G, Scaramelli, A, Scarpelli, A, Schaffer, T, Schellman, H, Schlabach, P, Schloesser, C, Schmitz, D, Schneps, J, Scholberg, K, Schukraft, A, Segreto, E, Sehrawat, S, Sensenig, J, Seong, I, Sepulveda-Quiroz, J, Sergi, A, Sergiampietri, F, Sessumes, D, Sexton, K, Sexton-Kennedy, L, Sgalaberna, D, Shaevitz, M, Shafaq, S, Shahi, J, Shahsavarani, S, Shanahan, P, Sharma, H, Sharma, R, Shaw, T, Shin, S, Shoemaker, I, Shooltz, D, Shrock, R, Simos, N, Sinclair, J, Sinev, G, Singh, V, Singh, J, Singh, I, Sipos, R, Sippach, F, Sirri, G, Siyeon, K, Smargianaki, D, Smith, A, Smith, E, Smith, P, Smolik, J, Smy, M, Snider, E, Snopok, P, Sobczyk, J, Sobel, H, Soderberg, M, Solano Salinas, C, Söldner-Rembold, S, Solomey, N, Sondheim, W, Sorel, M, Soto-Oton, J, Sousa, A, Soustruznik, K, Spagliardi, F, Spanu, M, Spitz, J, Spooner, N, Staley, R, Stancari, M, Stanco, L, Stefanik, A, Steiner, H, Stewart, J, Stock, J, Stocker, F, Stoica, S, Stone, J, Strait, J, Strait, M, Strauss, T, Striganov, S, Stuart, A, Sullivan, G, Sultana, M, Sun, Y, Surdo, A, Susic, V, Suter, L, Sutera, C, Svoboda, R, Szczerbinska, B, Szelc, A, Tagg, N, Talaga, R, Tanaka, H, Tapia Oregui, B, Tariq, S, Tatar, E, Tayloe, R, Tenti, M, Terao, K, Ternes, C, Terranova, F, Testera, G, Thea, A, Thompson, L, Thompson, J, Thorn, C, Timilsina, A, Timm, S, Todd, J, Tonazzo, A, Tope, T, Torbunov, D, Torti, M, Tórtola, M, Tortorici, F, Toups, M, Touramanis, C, Trevor, J, Tripathi, M, Tromeur, W, Tropin, I, Trzaska, W, Tsai, Y, Tsang, K, Tsaris, A, Tufanli, S, Tull, C, Turner, J, Tzanov, M, Tziaferi, E, Uchida, Y, Urheim, J, Usher, T, Valdiviesso, G, Valencia, E, Valerio, L, Vallari, Z, Valle, J, Van Berg, R, Van de Water, R, Varanini, F, Varner, G, Vasel, J, Vasseur, G, Vaziri, K, Velev, G, Ventura, S, Verdugo, A, Vermeulen, M, Vernon, E, Verzocchi, M, Viant, T, Vignoli, C, Vihonen, S, Vilela, C, Viren, B, Vokac, P, Vrba, T, Wachala, T, Wahl, D, Wallbank, M, Wang, H, Wang, J, Wang, T, Wang, B, Wang, Y, Wang, Z, Warburton, K, Warner, D, Wascko, M, Waters, D, Watson, A, Weber, A, Weber, M, Wei, H, Wei, W, Weinstein, A, Wenman, D, Wetstein, M, While, M, White, A, Whitehead, L, Whittington, D, Wierman, K, Wilking, M, Wilkinson, C, Willhite, J, Williams, Z, Wilson, R, Wilson, P, Wittich, P, Wolcott, J, Wongjirad, T, Wood, K, Wood, L, Worcester, E, Worcester, M, Wu, S, Wu, W, Xu, W, Yanagisawa, C, Yang, S, Yang, T, Yang, G, Ye, J, Yeh, M, Yershov, N, Yonehara, K, Yoshimura, L, Yu, B, Yu, J, Zalesak, J, Zambelli, L, Zamorano, B, Zani, A, Zaremba, K, Zazueta, L, Zeller, G, Zennamo, J, Zhang, C, Zhao, M, Zhou, Y, Zhu, G, Zimmerman, E, Zito, M, Zucchelli, S, Zuklin, J, Zutshi, V, Zwaska, R, DUNE Collaboration, B. Abi, R. Acciarri, M. A. Acero, M. Adamowski, C. Adams, D. Adams, P. Adamson, M. Adinolfi, Z. Ahmad, C. H. Albright, L. Aliaga Soplin, T. Alion, S. Alonso Monsalve, M. Alrashed, C. Alt, J. Anderson, K. Anderson, C. Andreopoulos, M. P. Andrews, R. A. Andrews, A. Ankowski, J. Anthony, M. Antonello, M. Antonova, S. Antusch, A. Aranda Fernandez, A. Ariga, T. Ariga, D. Aristizabal Sierra, E. Arrieta Diaz, J. Asaadi, M. Ascencio, D. Asner, M. S. Athar, M. Auger, A. Aurisano, V. Aushev, D. Autiero, F. Azfar, A. Back, H. Back, J. Back, C. Backhouse, P. Baesso, L. Bagby, X. Bai, M. Baird, B. Balantekin, S. Balasubramanian, B. Baller, P. Ballett, L. Balleyguier, B. Bambah, H. Band, M. Bansal, S. Bansal, G. Barenboim, G. J. Barker, C. Barnes, G. Barr, J. Barranco Monarca, N. Barros, J. Barrow, A. Bashyal, V. Basque, M. Bass, F. Bay, K. Bays, J. L. Bazo, J. F. Beacom, E. Bechetoille, B. R. Behera, L. Bellantoni, G. Bellettini, V. Bellini, O. Beltramello, D. Belver, N. Benekos, P. A. Benetti, A. Bercellie, E. Berman, P. Bernardini, R. Berner, H. G. Berns, R. H. Bernstein, S. Bertolucci, M. Betancourt, V. Bhatnagar, M. Bhattacharjee, B. Bhuyan, S. Biagi, J. Bian, K. Biery, B. Bilki, M. Bishai, A. Bitadze, T. Blackburn, A. Blake, B. Blanco Siffert, F. Blaszczyk, E. Blaufuss, G. C. Blazey, M. Blennow, E. Blucher, V. Bocean, F. Boffelli, J. Boissevain, S. Bolognesi, T. Bolton, M. Bonesini, T. Boone, A. Booth, C. Booth, S. Bordoni, A. Borkum, T. Boschi, P. Bour, B. Bourguille, S. B. Boyd, D. Boyden, J. Bracinik, D. Brailsford, A. Brandt, J. Bremer, S. J. Brice, C. Bromberg, G. Brooijmans, J. Brooke, G. Brown, N. Buchanan, H. Budd, P. C. de Holanda, T. Cai, D. Caiulo, P. Calafiura, A. Calatayud, J. Calcutt, C. Callahan, E. Calligarich, E. Calvo, L. Camilleri, A. Caminata, M. Campanelli, G. Cancelo, K. Cankocak, C. Cantini, D. Caratelli, B. Carlus, M. Carneiro, I. Caro Terrazas, T. J. Carroll, M. P. Carvallo, M. Cascella, C. Castromonte, E. Catano-Mur, M. Cavalli-Sforza, F. Cavanna, E. Cazzato, S. Centro, G. Cerati, A. Cervelli, A. Cervera Villanueva, T. Cervi, M. Chalifour, A. Chappuis, A. Chatterjee, S. Chattopadhyay, J. Chaves, H. Chen, M. -C. Chen, S. Chen, D. Cherdack, C. -Y. Chi, S. Childress, K. Cho, S. Choubey, B. C. Choudhary, A. Christensen, D. Christian, G. Christodoulou, C. -A. Christofferson, E. Church, P. Clarke, T. E. Coan, A. Cocco, G. H. Collin, E. Conley, J. M. Conrad, M. Convery, R. Corey, L. Corwin, P. Cotte, L. Cremonesi, J. I. Crespo-Anadón, J. Creus Prats, E. Cristaldo, P. Crivelli, D. Cronin-Hennessy, C. Crowley, C. Cuesta, A. Curioni, D. Cussans, M. Dabrowski, D. Dale, H. Da Motta, T. Davenne, E. Davenport, G. S. Davies, J. Davies, S. Davini, J. Dawson, K. De, M. P. Decowski, P. Dedin Neto, I. de Icaza Astiz, A. Delbart, D. Delepine, M. Delgado, A. Dell, J. de Mello Neto, D. DeMuth, Z. Deng, S. Dennis, C. Densham, I. De Bonis, A. De Gouvêa, P. De Jong, P. De Lurgio, S. De Rijck, A. De Roeck, J. J. de Vries, R. Dharmapalan, N. Dhingra, M. Diamantopoulou, F. Diaz, J. S. Díaz, G. Diaz Bautista, P. Ding, C. Distefano, M. Diwan, S. Di Domizio, L. Di Giulio, S. Di Luise, Z. Djurcic, F. Doizon, N. Dokania, M. J. Dolinski, R. Dong, J. dos Anjos, D. Douglas, G. Drake, D. Duchesneau, K. Duffy, B. Dung, D. Dutta, M. Duvernois, H. Duyang, O. Dvornikov, D. A. Dwyer, S. Dye, A. S. Dyshkant, S. Dytman, M. Eads, B. Eberly, D. Edmunds, J. Eisch, A. Elagin, S. Elliott, W. Ellsworth, M. Elnimr, S. Emery, S. Eno, A. Ereditato, C. O. Escobar, L. Escudero Sanchez, J. J. Evans, A. Ezeribe, K. Fahey, A. Falcone, L. Falk, A. Farbin, C. Farnese, Y. Farzan, M. Fasoli, A. Fava, J. Felix, E. Fernandez-Martinez, P. Fernandez Menendez, F. Ferraro, F. Feyzi, L. Fields, A. Filkins, F. Filthaut, A. Finch, O. Fischer, M. Fitton, R. Fitzpatrick, W. Flanagan, B. T. Fleming, R. Flight, T. Forest, J. Fowler, W. Fox, J. Franc, K. Francis, P. Franchini, D. Franco, J. Freeman, J. Freestone, J. Fried, A. Friedland, S. Fuess, I. Furic, A. Furmanski, A. M. Gago, H. Gallagher, A. Gallego-Ros, V. Galymov, E. Gamberini, S. Gambetta, T. Gamble, R. Gandhi, R. Gandrajula, S. Gao, D. Garcia-Gamez, S. Gardiner, D. Gastler, J. Gehrlein, B. Gelli, A. Gendotti, Z. Ghorbani-Moghaddam, A. Ghosh, D. Gibin, I. Gil-Botella, C. Girerd, A. K. Giri, S. Glavin, D. Goeldi, O. Gogota, M. Gold, S. Gollapinni, K. Gollwitzer, R. A. Gomes, L. Gomez, L. V. Gomez Bermeo, J. J. Gomez Cadenas, H. Gong, F. Gonnella, J. A. Gonzalez-Cuevas, M. Goodman, O. Goodwin, D. Gorbunov, S. Goswami, E. Goudzovski, C. Grace, N. Graf, M. Graham, E. Gramellini, R. Gran, A. Grant, C. Grant, N. Grant, V. Greco, S. Green, H. Greenlee, L. Greenler, M. Greenwood, J. Greer, W. C. Griffith, M. Groh, J. Grudzinski, K. Grzelak, G. Guanghua, E. Guardincerri, V. Guarino, G. P. Guedes, R. Guenette, A. Guglielmi, B. Guo, S. Gupta, V. Gupta, K. K. Guthikonda, R. Gutierrez, P. Guzowski, M. M. Guzzo, A. Habig, R. W. Hackenburg, A. Hackenburg, B. Hackett, H. Hadavand, R. Haenni, A. Hahn, J. Haigh, T. Haines, J. Haiston, T. Hamernik, P. Hamilton, J. Han, T. Handler, S. Hans, D. A. Harris, J. Hartnell, T. Hasegawa, R. Hatcher, A. Hatzikoutelis, S. Hays, E. Hazen, M. Headley, A. Heavey, K. Heegerv, J. Heise, K. Hennessy, S. Henry, A. Hernandez, J. Hernandez-Garcia, K. Herner, J. Hewes, J. Hignight, A. Higuera, T. Hill, S. Hillier, A. Himmel, C. Hohl, A. Holin, E. Hoppe, S. Horikawa, G. Horton-Smith, M. Hostert, A. Hourlier, B. Howard, R. Howell, J. Huang, J. Hugon, P. Hurh, J. Hylen, R. Illingworth, J. Insler, G. Introzzi, A. Ioannisian, A. Izmaylov, D. E. Jaffe, C. James, E. James, C. -H. Jang, F. Jediny, Y. S. Jeong, A. Jhingan, W. Ji, A. Jipa, S. Jiménez, C. Johnson, M. Johnson, R. Johnson, J. Johnstone, B. Jones, S. Jones, J. Joshi, H. Jostlein, C. K. Jung, T. Junk, A. Kaboth, I. Kadenko, F. Kamiya, Y. Kamyshkov, G. Karagiorgi, D. Karasavvas, Y. Karyotakis, S. Kasai, S. Kasetti, K. Kaur, B. Kayser, N. Kazaryan, E. Kearns, P. Keener, E. Kemp, C. Kendziora, W. Ketchum, S. H. Kettell, M. Khabibullin, A. Khotjantsev, D. Kim, B. Kirby, M. Kirby, J. Klein, Y. -J. Ko, T. Kobilarcik, B. Kocaman, L. W. Koerner, S. Kohn, G. Koizumi, P. Koller, A. Kopylov, M. Kordosky, L. Kormos, T. Kosc, U. Kose, V. A. Kostelecký, K. Kothekar, M. Kramer, F. Krennrich, I. Kreslo, K. Kriesel, W. Kropp, Y. Kudenko, V. A. Kudryavtsev, S. Kulagin, J. Kumar, L. Kumar, A. Kumar, S. Kumbhare, C. Kuruppu, V. Kus, T. Kutter, R. LaZur, K. Lande, C. Lane, K. Lang, T. Langford, F. Lanni, P. Lasorak, D. Last, C. Lastoria, A. Laundrie, I. Lazanu, T. Le, J. Learned, P. Lebrun, D. Lee, G. Lehmann Miotto, M. A. Leigui de Oliveira, Q. Li, S. Li, S. W. Li, X. Li, Y. Li, Z. Li, H. -Y. Liao, S. -K. Lin, C-J. S. Lin, R. Linehan, V. Linhart, J. Link, Z. Liptak, D. Lissauer, L. Littenberg, B. Littlejohn, J. Liu, T. Liu, L. LoMonaco, J. M. LoSecco, S. Lockwitz, N. Lockyer, T. Loew, M. Lokajicek, K. Long, K. Loo, J. P. Lopez, D. Lorca, T. Lord, M. Losada, W. C. Louis, M. Luethi, K. -B. Luk, T. Lundin, X. Luo, N. Lurkin, T. Lux, V. P. Luzio, J. Lykken, J. Maalampi, R. MacLellan, A. A. Machado, P. Machado, C. T. Macias, J. Macier, P. Madigan, S. Magill, G. Mahler, K. Mahn, M. Malek, J. A. Maloney, F. Mammoliti, S. K. Mandal, G. Mandrioli, L. Manenti, S. Manly, A. Mann, A. Marchionni, W. Marciano, S. Marcocci, D. Marfatia, C. Mariani, J. Maricic, F. Marinho, A. D. Marino, M. Marshak, C. Marshall, J. Marshall, J. Marteau, J. Martin-Albo, D. Martinez, N. Martinez, H. Martinez, K. Mason, A. Mastbaum, M. Masud, H. Mathez, S. Matsuno, J. Matthews, C. Mauger, N. Mauri, K. Mavrokoridis, R. Mazza, A. Mazzacane, E. Mazzucato, N. McCauley, E. McCluskey, N. McConkey, K. McDonald, K. S. McFarland, C. McGivern, A. McGowan, C. McGrew, R. McKeown, A. McNab, D. McNulty, R. McTaggart, V. Meddage, A. Mefodiev, P. Mehta, D. Mei, O. Mena, S. Menary, H. Mendez, D. P. Mendez, A. Menegolli, G. Meng, M. Messier, W. Metcalf, M. Mewes, H. Meyer, T. Miao, J. Migenda, R. Milincic, J. Miller, W. Miller, J. Mills, C. Milne, O. Mineev, O. Miranda, C. S. Mishra, S. R. Mishra, A. Mislivec, B. Mitrica, D. Mladenov, I. Mocioiu, K. Moffat, N. Moggi, R. Mohanta, N. Mokhov, J. Molina, L. Molina Bueno, A. Montanari, C. Montanari, D. Montanari, L. Montano Zetina, J. Moon, M. Mooney, C. Moore, D. Moreno, B. Morgan, G. F. Moroni, C. Morris, W. Morse, C. Mossey, C. A. Moura, J. Mousseau, L. Mualem, M. Muether, S. Mufson, F. Muheim, H. Muramatsu, S. Murphy, J. Musser, J. Nachtman, M. Nalbandyan, R. Nandakumar, D. Naples, S. Narita, G. Navarro, J. Navarro, D. Navas-Nicolás, N. Nayak, M. Nebot-Guinot, M. Needham, K. Negishi, J. Nelson, M. Nessi, D. Newbold, M. Newcomer, R. Nichol, T. C. Nicholls, E. Niner, A. Norman, B. Norris, J. Norris, P. Novella, E. Nowak, J. Nowak, M. S. Nunes, H. O'Keeffe, M. Oberling, A. Olivares Del Campo, A. Olivier, Y. Onel, Y. Onishchuk, T. Ovsjannikova, S. Ozturk, L. Pagani, S. Pakvasa, O. Palamara, J. Paley, M. Pallavicini, C. Palomares, J. Palomino, E. Pantic, A. Paolo, V. Paolone, V. Papadimitriou, R. Papaleo, S. Paramesvaran, J. Park, S. Parke, Z. Parsa, S. Pascoli, J. Pasternak, J. Pater, L. Patrizii, R. B. Patterson, S. J. Patton, T. Patzak, A. Paudel, B. Paulos, L. Paulucci, Z. Pavlovic, G. Pawloski, P. Payam, D. Payne, V. Pec, S. J. M. Peeters, E. Pennacchio, A. Penzo, G. N. Perdue, O. l. G. Peres, L. Periale, K. Petridis, G. Petrillo, R. Petti, P. Picchi, L. Pickering, F. Pietropaolo, J. Pillow, P. Plonski, R. Plunkett, R. Poling, X. Pons, N. Poonthottathil, M. Popovic, R. Pordes, S. Pordes, M. Potekhin, R. Potenza, B. Potukuchi, S. Poudel, J. Pozimski, M. Pozzato, T. Prakasj, R. Preece, O. Prokofiev, N. Pruthi, P. Przewlocki, F. Psihas, D. PugnËre, D. Pushka, K. Qi, X. Qian, J. L. Raaf, R. Raboanary, V. Radeka, J. Rademacker, V. Radescu, B. Radics, A. Radovic, A. Rafique, M. Rajaoalisoa, I. Rakhno, H. T. Rakotondramanana, L. Rakotondravohitra, Y. A. Ramachers, R. A. Rameika, M. A. Ramirez Delgado, J. Ramsey, B. J. Ramson, A. Rappoldi, G. L. Raselli, P. Ratoff, S. Ravat, O. Ravinez, H. Razafinime, B. Rebel, D. Redondo, C. Regenfus, M. Reggiani-Guzzo, T. Rehak, J. Reichenbacher, D. Reitzner, M. H. Reno, A. Renshaw, S. Rescia, F. Resnati, A. Reynolds, G. Riccobene, L. C. J. Rice, K. Rielage, K. Riesselmann, Y. -A. Rigaut, D. Rivera, L. Rochester, M. Roda, P. Rodrigues, M. J. Rodriguez Alonso, B. Roe, A. J. Roeth, R. M. Roser, M. Ross-Lonergan, M. Rossella, J. Rout, S. Roy, A. Rubbia, C. Rubbia, R. Rucinski, B. Russell, J. Russell, D. Ruterbories, M. R. Vagins, R. Saakyan, N. Sahu, P. Sala, G. Salukvadze, N. Samios, F. Sanchez, M. C. Sanchez, C. Sandoval, B. Sands, S. U. Sankar, S. Santana, L. M. Santos, G. Santucci, N. Saoulidou, P. Sapienza, C. Sarasty, I. Sarcevic, G. Savage, A. Scaramelli, A. Scarpelli, T. Schaffer, H. Schellman, P. Schlabach, C. M. Schloesser, D. W. Schmitz, J. Schneps, K. Scholberg, A. Schukraft, E. Segreto, S. Sehrawat, J. Sensenig, I. Seong, J. A. Sepulveda-Quiroz, A. Sergi, F. Sergiampietri, D. Sessumes, K. Sexton, L. Sexton-Kennedy, D. Sgalaberna, M. H. Shaevitz, S. Shafaq, J. S. Shahi, S. Shahsavarani, P. Shanahan, H. R. Sharma, R. Sharma, R. K. Sharma, T. Shaw, S. Shin, I. Shoemaker, D. Shooltz, R. Shrock, N. Simos, J. Sinclair, G. Sinev, V. Singh, J. Singh, I. Singh, R. Sipos, F. W. Sippach, G. Sirri, K. Siyeon, D. Smargianaki, A. Smith, E. Smith, P. Smith, J. Smolik, M. Smy, E. L. Snider, P. Snopok, J. Sobczyk, H. Sobel, M. Soderberg, C. J. Solano Salinas, S. Söldner-Rembold, N. Solomey, W. Sondheim, M. Sorel, J. A. Soto-Oton, A. Sousa, K. Soustruznik, F. Spagliardi, M. Spanu, J. Spitz, N. J. C. Spooner, R. Staley, M. Stancari, L. Stanco, A. Stefanik, H. M. Steiner, J. Stewart, J. Stock, F. Stocker, S. Stoica, J. Stone, J. Strait, M. Strait, T. Strauss, S. Striganov, A. Stuart, G. Sullivan, M. Sultana, Y. Sun, A. Surdo, V. Susic, L. Suter, C. M. Sutera, R. Svoboda, B. Szczerbinska, A. M. Szelc, N. Tagg, R. Talaga, H. Tanaka, B. Tapia Oregui, S. Tariq, E. Tatar, R. Tayloe, M. Tenti, K. Terao, C. A. Ternes, F. Terranova, G. Testera, A. Thea, L. F. Thompson, J. Thompson, C. Thorn, A. Timilsina, S. C. Timm, J. Todd, A. Tonazzo, T. Tope, D. Torbunov, M. Torti, M. Tórtola, F. Tortorici, M. Toups, C. Touramanis, J. Trevor, M. Tripathi, W. Tromeur, I. Tropin, W. H. Trzaska, Y. -T. Tsai, K. V. Tsang, A. Tsaris, S. Tufanli, C. Tull, J. Turner, M. Tzanov, E. Tziaferi, Y. Uchida, J. Urheim, T. Usher, G. A. Valdiviesso, E. Valencia, L. Valerio, Z. Vallari, J. W. F. Valle, R. Van Berg, R. Van de Water, F. Varanini, G. Varner, J. Vasel, G. Vasseur, K. Vaziri, G. Velev, S. Ventura, A. Verdugo, M. Vermeulen, E. Vernon, M. Verzocchi, T. Viant, C. Vignoli, S. Vihonen, C. Vilela, B. Viren, P. Vokac, T. Vrba, T. Wachala, D. Wahl, M. Wallbank, H. Wang, J. Wang, T. -C. Wang, B. Wang, Y. Wang, Z. Wang, K. Warburton, D. Warner, M. O. Wascko, D. Waters, A. Watson, A. Weber, M. Weber, H. Wei, W. Wei, A. Weinstein, D. Wenman, M. Wetstein, M. While, A. White, L. H. Whitehead, D. Whittington, K. Wierman, M. Wilking, C. Wilkinson, J. Willhite, Z. Williams, R. J. Wilson, P. Wilson, P. Wittich, J. Wolcott, T. Wongjirad, K. Wood, L. Wood, E. Worcester, M. Worcester, S. Wu, W. Wu, W. Xu, C. Yanagisawa, S. Yang, T. Yang, G. Yang, J. Ye, M. Yeh, N. Yershov, K. Yonehara, L. Yoshimura, B. Yu, J. Yu, J. Zalesak, L. Zambelli, B. Zamorano, A. Zani, K. Zaremba, L. Zazueta, G. P. Zeller, J. Zennamo, C. Zhang, M. Zhao, Y. -L. Zhou, G. Zhu, E. D. Zimmerman, M. Zito, S. Zucchelli, J. Zuklin, V. Zutshi, R. Zwaska, Collaboration, D, Abi, B, Acciarri, R, Acero, M, Adamowski, M, Adams, C, Adams, D, Adamson, P, Adinolfi, M, Ahmad, Z, Albright, C, Aliaga Soplin, L, Alion, T, Alonso Monsalve, S, Alrashed, M, Alt, C, Anderson, J, Anderson, K, Andreopoulos, C, Andrews, M, Andrews, R, Ankowski, A, Anthony, J, Antonello, M, Antonova, M, Antusch, S, Aranda Fernandez, A, Ariga, A, Ariga, T, Aristizabal Sierra, D, Arrieta Diaz, E, Asaadi, J, Ascencio, M, Asner, D, Athar, M, Auger, M, Aurisano, A, Aushev, V, Autiero, D, Azfar, F, Back, A, Back, H, Back, J, Backhouse, C, Baesso, P, Bagby, L, Bai, X, Baird, M, Balantekin, B, Balasubramanian, S, Baller, B, Ballett, P, Balleyguier, L, Bambah, B, Band, H, Bansal, M, Bansal, S, Barenboim, G, Barker, G, Barnes, C, Barr, G, Barranco Monarca, J, Barros, N, Barrow, J, Bashyal, A, Basque, V, Bass, M, Bay, F, Bays, K, Bazo, J, Beacom, J, Bechetoille, E, Behera, B, Bellantoni, L, Bellettini, G, Bellini, V, Beltramello, O, Belver, D, Benekos, N, Benetti, P, Bercellie, A, Berman, E, Bernardini, P, Berner, R, Berns, H, Bernstein, R, Bertolucci, S, Betancourt, M, Bhatnagar, V, Bhattacharjee, M, Bhuyan, B, Biagi, S, Bian, J, Biery, K, Bilki, B, Bishai, M, Bitadze, A, Blackburn, T, Blake, A, Blanco Siffert, B, Blaszczyk, F, Blaufuss, E, Blazey, G, Blennow, M, Blucher, E, Bocean, V, Boffelli, F, Boissevain, J, Bolognesi, S, Bolton, T, Bonesini, M, Boone, T, Booth, A, Booth, C, Bordoni, S, Borkum, A, Boschi, T, Bour, P, Bourguille, B, Boyd, S, Boyden, D, Bracinik, J, Brailsford, D, Brandt, A, Bremer, J, Brice, S, Bromberg, C, Brooijmans, G, Brooke, J, Brown, G, Buchanan, N, Budd, H, de Holanda, P, Cai, T, Caiulo, D, Calafiura, P, Calatayud, A, Calcutt, J, Callahan, C, Calligarich, E, Calvo, E, Camilleri, L, Caminata, A, Campanelli, M, Cancelo, G, Cankocak, K, Cantini, C, Caratelli, D, Carlus, B, Carneiro, M, Caro Terrazas, I, Carroll, T, Carvallo, M, Cascella, M, Castromonte, C, Catano-Mur, E, Cavalli-Sforza, M, Cavanna, F, Cazzato, E, Centro, S, Cerati, G, Cervelli, A, Cervera Villanueva, A, Cervi, T, Chalifour, M, Chappuis, A, Chatterjee, A, Chattopadhyay, S, Chaves, J, Chen, H, Chen, M, Chen, S, Cherdack, D, Chi, C, Childress, S, Cho, K, Choubey, S, Choudhary, B, Christensen, A, Christian, D, Christodoulou, G, Christofferson, C, Church, E, Clarke, P, Coan, T, Cocco, A, Collin, G, Conley, E, Conrad, J, Convery, M, Corey, R, Corwin, L, Cotte, P, Cremonesi, L, Crespo-Anadón, J, Creus Prats, J, Cristaldo, E, Crivelli, P, Cronin-Hennessy, D, Crowley, C, Cuesta, C, Curioni, A, Cussans, D, Dabrowski, M, Dale, D, Da Motta, H, Davenne, T, Davenport, E, Davies, G, Davies, J, Davini, S, Dawson, J, De, K, Decowski, M, Dedin Neto, P, de Icaza Astiz, I, Delbart, A, Delepine, D, Delgado, M, Dell, A, de Mello Neto, J, Demuth, D, Deng, Z, Dennis, S, Densham, C, De Bonis, I, De Gouvêa, A, De Jong, P, De Lurgio, P, De Rijck, S, De Roeck, A, de Vries, J, Dharmapalan, R, Dhingra, N, Diamantopoulou, M, Diaz, F, Díaz, J, Diaz Bautista, G, Ding, P, Distefano, C, Diwan, M, Di Domizio, S, Di Giulio, L, Di Luise, S, Djurcic, Z, Doizon, F, Dokania, N, Dolinski, M, Dong, R, dos Anjos, J, Douglas, D, Drake, G, Duchesneau, D, Duffy, K, Dung, B, Dutta, D, Duvernois, M, Duyang, H, Dvornikov, O, Dwyer, D, Dye, S, Dyshkant, A, Dytman, S, Eads, M, Eberly, B, Edmunds, D, Eisch, J, Elagin, A, Elliott, S, Ellsworth, W, Elnimr, M, Emery, S, Eno, S, Ereditato, A, Escobar, C, Escudero Sanchez, L, Evans, J, Ezeribe, A, Fahey, K, Falcone, A, Falk, L, Farbin, A, Farnese, C, Farzan, Y, Fasoli, M, Fava, A, Felix, J, Fernandez-Martinez, E, Fernandez Menendez, P, Ferraro, F, Feyzi, F, Fields, L, Filkins, A, Filthaut, F, Finch, A, Fischer, O, Fitton, M, Fitzpatrick, R, Flanagan, W, Fleming, B, Flight, R, Forest, T, Fowler, J, Fox, W, Franc, J, Francis, K, Franchini, P, Franco, D, Freeman, J, Freestone, J, Fried, J, Friedland, A, Fuess, S, Furic, I, Furmanski, A, Gago, A, Gallagher, H, Gallego-Ros, A, Galymov, V, Gamberini, E, Gambetta, S, Gamble, T, Gandhi, R, Gandrajula, R, Gao, S, Garcia-Gamez, D, Gardiner, S, Gastler, D, Gehrlein, J, Gelli, B, Gendotti, A, Ghorbani-Moghaddam, Z, Ghosh, A, Gibin, D, Gil-Botella, I, Girerd, C, Giri, A, Glavin, S, Goeldi, D, Gogota, O, Gold, M, Gollapinni, S, Gollwitzer, K, Gomes, R, Gomez, L, Gomez Bermeo, L, Gomez Cadenas, J, Gong, H, Gonnella, F, Gonzalez-Cuevas, J, Goodman, M, Goodwin, O, Gorbunov, D, Goswami, S, Goudzovski, E, Grace, C, Graf, N, Graham, M, Gramellini, E, Gran, R, Grant, A, Grant, C, Grant, N, Greco, V, Green, S, Greenlee, H, Greenler, L, Greenwood, M, Greer, J, Griffith, W, Groh, M, Grudzinski, J, Grzelak, K, Guanghua, G, Guardincerri, E, Guarino, V, Guedes, G, Guenette, R, Guglielmi, A, Guo, B, Gupta, S, Gupta, V, Guthikonda, K, Gutierrez, R, Guzowski, P, Guzzo, M, Habig, A, Hackenburg, R, Hackenburg, A, Hackett, B, Hadavand, H, Haenni, R, Hahn, A, Haigh, J, Haines, T, Haiston, J, Hamernik, T, Hamilton, P, Han, J, Handler, T, Hans, S, Harris, D, Hartnell, J, Hasegawa, T, Hatcher, R, Hatzikoutelis, A, Hays, S, Hazen, E, Headley, M, Heavey, A, Heegerv, K, Heise, J, Hennessy, K, Henry, S, Hernandez, A, Hernandez-Garcia, J, Herner, K, Hewes, J, Hignight, J, Higuera, A, Hill, T, Hillier, S, Himmel, A, Hohl, C, Holin, A, Hoppe, E, Horikawa, S, Horton-Smith, G, Hostert, M, Hourlier, A, Howard, B, Howell, R, Huang, J, Hugon, J, Hurh, P, Hylen, J, Illingworth, R, Insler, J, Introzzi, G, Ioannisian, A, Izmaylov, A, Jaffe, D, James, C, James, E, Jang, C, Jediny, F, Jeong, Y, Jhingan, A, Ji, W, Jipa, A, Jiménez, S, Johnson, C, Johnson, M, Johnson, R, Johnstone, J, Jones, B, Jones, S, Joshi, J, Jostlein, H, Jung, C, Junk, T, Kaboth, A, Kadenko, I, Kamiya, F, Kamyshkov, Y, Karagiorgi, G, Karasavvas, D, Karyotakis, Y, Kasai, S, Kasetti, S, Kaur, K, Kayser, B, Kazaryan, N, Kearns, E, Keener, P, Kemp, E, Kendziora, C, Ketchum, W, Kettell, S, Khabibullin, M, Khotjantsev, A, Kim, D, Kirby, B, Kirby, M, Klein, J, Ko, Y, Kobilarcik, T, Kocaman, B, Koerner, L, Kohn, S, Koizumi, G, Koller, P, Kopylov, A, Kordosky, M, Kormos, L, Kosc, T, Kose, U, Kostelecký, V, Kothekar, K, Kramer, M, Krennrich, F, Kreslo, I, Kriesel, K, Kropp, W, Kudenko, Y, Kudryavtsev, V, Kulagin, S, Kumar, J, Kumar, L, Kumar, A, Kumbhare, S, Kuruppu, C, Kus, V, Kutter, T, Lazur, R, Lande, K, Lane, C, Lang, K, Langford, T, Lanni, F, Lasorak, P, Last, D, Lastoria, C, Laundrie, A, Lazanu, I, Le, T, Learned, J, Lebrun, P, Lee, D, Lehmann Miotto, G, Leigui de Oliveira, M, Li, Q, Li, S, Li, X, Li, Y, Li, Z, Liao, H, Lin, S, Lin, C, Linehan, R, Linhart, V, Link, J, Liptak, Z, Lissauer, D, Littenberg, L, Littlejohn, B, Liu, J, Liu, T, Lomonaco, L, Losecco, J, Lockwitz, S, Lockyer, N, Loew, T, Lokajicek, M, Long, K, Loo, K, Lopez, J, Lorca, D, Lord, T, Losada, M, Louis, W, Luethi, M, Luk, K, Lundin, T, Luo, X, Lurkin, N, Lux, T, Luzio, V, Lykken, J, Maalampi, J, Maclellan, R, Machado, A, Machado, P, Macias, C, Macier, J, Madigan, P, Magill, S, Mahler, G, Mahn, K, Malek, M, Maloney, J, Mammoliti, F, Mandal, S, Mandrioli, G, Manenti, L, Manly, S, Mann, A, Marchionni, A, Marciano, W, Marcocci, S, Marfatia, D, Mariani, C, Maricic, J, Marinho, F, Marino, A, Marshak, M, Marshall, C, Marshall, J, Marteau, J, Martin-Albo, J, Martinez, D, Martinez, N, Martinez, H, Mason, K, Mastbaum, A, Masud, M, Mathez, H, Matsuno, S, Matthews, J, Mauger, C, Mauri, N, Mavrokoridis, K, Mazza, R, Mazzacane, A, Mazzucato, E, Mccauley, N, Mccluskey, E, Mcconkey, N, Mcdonald, K, Mcfarland, K, Mcgivern, C, Mcgowan, A, Mcgrew, C, Mckeown, R, Mcnab, A, Mcnulty, D, Mctaggart, R, Meddage, V, Mefodiev, A, Mehta, P, Mei, D, Mena, O, Menary, S, Mendez, H, Mendez, D, Menegolli, A, Meng, G, Messier, M, Metcalf, W, Mewes, M, Meyer, H, Miao, T, Migenda, J, Milincic, R, Miller, J, Miller, W, Mills, J, Milne, C, Mineev, O, Miranda, O, Mishra, C, Mishra, S, Mislivec, A, Mitrica, B, Mladenov, D, Mocioiu, I, Moffat, K, Moggi, N, Mohanta, R, Mokhov, N, Molina, J, Molina Bueno, L, Montanari, A, Montanari, C, Montanari, D, Montano Zetina, L, Moon, J, Mooney, M, Moore, C, Moreno, D, Morgan, B, Moroni, G, Morris, C, Morse, W, Mossey, C, Moura, C, Mousseau, J, Mualem, L, Muether, M, Mufson, S, Muheim, F, Muramatsu, H, Murphy, S, Musser, J, Nachtman, J, Nalbandyan, M, Nandakumar, R, Naples, D, Narita, S, Navarro, G, Navarro, J, Navas-Nicolás, D, Nayak, N, Nebot-Guinot, M, Needham, M, Negishi, K, Nelson, J, Nessi, M, Newbold, D, Newcomer, M, Nichol, R, Nicholls, T, Niner, E, Norman, A, Norris, B, Norris, J, Novella, P, Nowak, E, Nowak, J, Nunes, M, O'Keeffe, H, Oberling, M, Olivares Del Campo, A, Olivier, A, Onel, Y, Onishchuk, Y, Ovsjannikova, T, Ozturk, S, Pagani, L, Pakvasa, S, Palamara, O, Paley, J, Pallavicini, M, Palomares, C, Palomino, J, Pantic, E, Paolo, A, Paolone, V, Papadimitriou, V, Papaleo, R, Paramesvaran, S, Park, J, Parke, S, Parsa, Z, Pascoli, S, Pasternak, J, Pater, J, Patrizii, L, Patterson, R, Patton, S, Patzak, T, Paudel, A, Paulos, B, Paulucci, L, Pavlovic, Z, Pawloski, G, Payam, P, Payne, D, Pec, V, Peeters, S, Pennacchio, E, Penzo, A, Perdue, G, Peres, O, Periale, L, Petridis, K, Petrillo, G, Petti, R, Picchi, P, Pickering, L, Pietropaolo, F, Pillow, J, Plonski, P, Plunkett, R, Poling, R, Pons, X, Poonthottathil, N, Popovic, M, Pordes, R, Pordes, S, Potekhin, M, Potenza, R, Potukuchi, B, Poudel, S, Pozimski, J, Pozzato, M, Prakasj, T, Preece, R, Prokofiev, O, Pruthi, N, Przewlocki, P, Psihas, F, Pugnëre, D, Pushka, D, Qi, K, Qian, X, Raaf, J, Raboanary, R, Radeka, V, Rademacker, J, Radescu, V, Radics, B, Radovic, A, Rafique, A, Rajaoalisoa, M, Rakhno, I, Rakotondramanana, H, Rakotondravohitra, L, Ramachers, Y, Rameika, R, Ramirez Delgado, M, Ramsey, J, Ramson, B, Rappoldi, A, Raselli, G, Ratoff, P, Ravat, S, Ravinez, O, Razafinime, H, Rebel, B, Redondo, D, Regenfus, C, Reggiani-Guzzo, M, Rehak, T, Reichenbacher, J, Reitzner, D, Reno, M, Renshaw, A, Rescia, S, Resnati, F, Reynolds, A, Riccobene, G, Rice, L, Rielage, K, Riesselmann, K, Rigaut, Y, Rivera, D, Rochester, L, Roda, M, Rodrigues, P, Rodriguez Alonso, M, Roe, B, Roeth, A, Roser, R, Ross-Lonergan, M, Rossella, M, Rout, J, Roy, S, Rubbia, A, Rubbia, C, Rucinski, R, Russell, B, Russell, J, Ruterbories, D, Vagins, M, Saakyan, R, Sahu, N, Sala, P, Salukvadze, G, Samios, N, Sanchez, F, Sanchez, M, Sandoval, C, Sands, B, Sankar, S, Santana, S, Santos, L, Santucci, G, Saoulidou, N, Sapienza, P, Sarasty, C, Sarcevic, I, Savage, G, Scaramelli, A, Scarpelli, A, Schaffer, T, Schellman, H, Schlabach, P, Schloesser, C, Schmitz, D, Schneps, J, Scholberg, K, Schukraft, A, Segreto, E, Sehrawat, S, Sensenig, J, Seong, I, Sepulveda-Quiroz, J, Sergi, A, Sergiampietri, F, Sessumes, D, Sexton, K, Sexton-Kennedy, L, Sgalaberna, D, Shaevitz, M, Shafaq, S, Shahi, J, Shahsavarani, S, Shanahan, P, Sharma, H, Sharma, R, Shaw, T, Shin, S, Shoemaker, I, Shooltz, D, Shrock, R, Simos, N, Sinclair, J, Sinev, G, Singh, V, Singh, J, Singh, I, Sipos, R, Sippach, F, Sirri, G, Siyeon, K, Smargianaki, D, Smith, A, Smith, E, Smith, P, Smolik, J, Smy, M, Snider, E, Snopok, P, Sobczyk, J, Sobel, H, Soderberg, M, Solano Salinas, C, Söldner-Rembold, S, Solomey, N, Sondheim, W, Sorel, M, Soto-Oton, J, Sousa, A, Soustruznik, K, Spagliardi, F, Spanu, M, Spitz, J, Spooner, N, Staley, R, Stancari, M, Stanco, L, Stefanik, A, Steiner, H, Stewart, J, Stock, J, Stocker, F, Stoica, S, Stone, J, Strait, J, Strait, M, Strauss, T, Striganov, S, Stuart, A, Sullivan, G, Sultana, M, Sun, Y, Surdo, A, Susic, V, Suter, L, Sutera, C, Svoboda, R, Szczerbinska, B, Szelc, A, Tagg, N, Talaga, R, Tanaka, H, Tapia Oregui, B, Tariq, S, Tatar, E, Tayloe, R, Tenti, M, Terao, K, Ternes, C, Terranova, F, Testera, G, Thea, A, Thompson, L, Thompson, J, Thorn, C, Timilsina, A, Timm, S, Todd, J, Tonazzo, A, Tope, T, Torbunov, D, Torti, M, Tórtola, M, Tortorici, F, Toups, M, Touramanis, C, Trevor, J, Tripathi, M, Tromeur, W, Tropin, I, Trzaska, W, Tsai, Y, Tsang, K, Tsaris, A, Tufanli, S, Tull, C, Turner, J, Tzanov, M, Tziaferi, E, Uchida, Y, Urheim, J, Usher, T, Valdiviesso, G, Valencia, E, Valerio, L, Vallari, Z, Valle, J, Van Berg, R, Van de Water, R, Varanini, F, Varner, G, Vasel, J, Vasseur, G, Vaziri, K, Velev, G, Ventura, S, Verdugo, A, Vermeulen, M, Vernon, E, Verzocchi, M, Viant, T, Vignoli, C, Vihonen, S, Vilela, C, Viren, B, Vokac, P, Vrba, T, Wachala, T, Wahl, D, Wallbank, M, Wang, H, Wang, J, Wang, T, Wang, B, Wang, Y, Wang, Z, Warburton, K, Warner, D, Wascko, M, Waters, D, Watson, A, Weber, A, Weber, M, Wei, H, Wei, W, Weinstein, A, Wenman, D, Wetstein, M, While, M, White, A, Whitehead, L, Whittington, D, Wierman, K, Wilking, M, Wilkinson, C, Willhite, J, Williams, Z, Wilson, R, Wilson, P, Wittich, P, Wolcott, J, Wongjirad, T, Wood, K, Wood, L, Worcester, E, Worcester, M, Wu, S, Wu, W, Xu, W, Yanagisawa, C, Yang, S, Yang, T, Yang, G, Ye, J, Yeh, M, Yershov, N, Yonehara, K, Yoshimura, L, Yu, B, Yu, J, Zalesak, J, Zambelli, L, Zamorano, B, Zani, A, Zaremba, K, Zazueta, L, Zeller, G, Zennamo, J, Zhang, C, Zhao, M, Zhou, Y, Zhu, G, Zimmerman, E, Zito, M, Zucchelli, S, Zuklin, J, Zutshi, V, Zwaska, R, DUNE Collaboration, B. Abi, R. Acciarri, M. A. Acero, M. Adamowski, C. Adams, D. Adams, P. Adamson, M. Adinolfi, Z. Ahmad, C. H. Albright, L. Aliaga Soplin, T. Alion, S. Alonso Monsalve, M. Alrashed, C. Alt, J. Anderson, K. Anderson, C. Andreopoulos, M. P. Andrews, R. A. Andrews, A. Ankowski, J. Anthony, M. Antonello, M. Antonova, S. Antusch, A. Aranda Fernandez, A. Ariga, T. Ariga, D. Aristizabal Sierra, E. Arrieta Diaz, J. Asaadi, M. Ascencio, D. Asner, M. S. Athar, M. Auger, A. Aurisano, V. Aushev, D. Autiero, F. Azfar, A. Back, H. Back, J. Back, C. Backhouse, P. Baesso, L. Bagby, X. Bai, M. Baird, B. Balantekin, S. Balasubramanian, B. Baller, P. Ballett, L. Balleyguier, B. Bambah, H. Band, M. Bansal, S. Bansal, G. Barenboim, G. J. Barker, C. Barnes, G. Barr, J. Barranco Monarca, N. Barros, J. Barrow, A. Bashyal, V. Basque, M. Bass, F. Bay, K. Bays, J. L. Bazo, J. F. Beacom, E. Bechetoille, B. R. Behera, L. Bellantoni, G. Bellettini, V. Bellini, O. Beltramello, D. Belver, N. Benekos, P. A. Benetti, A. Bercellie, E. Berman, P. Bernardini, R. Berner, H. G. Berns, R. H. Bernstein, S. Bertolucci, M. Betancourt, V. Bhatnagar, M. Bhattacharjee, B. Bhuyan, S. Biagi, J. Bian, K. Biery, B. Bilki, M. Bishai, A. Bitadze, T. Blackburn, A. Blake, B. Blanco Siffert, F. Blaszczyk, E. Blaufuss, G. C. Blazey, M. Blennow, E. Blucher, V. Bocean, F. Boffelli, J. Boissevain, S. Bolognesi, T. Bolton, M. Bonesini, T. Boone, A. Booth, C. Booth, S. Bordoni, A. Borkum, T. Boschi, P. Bour, B. Bourguille, S. B. Boyd, D. Boyden, J. Bracinik, D. Brailsford, A. Brandt, J. Bremer, S. J. Brice, C. Bromberg, G. Brooijmans, J. Brooke, G. Brown, N. Buchanan, H. Budd, P. C. de Holanda, T. Cai, D. Caiulo, P. Calafiura, A. Calatayud, J. Calcutt, C. Callahan, E. Calligarich, E. Calvo, L. Camilleri, A. Caminata, M. Campanelli, G. Cancelo, K. Cankocak, C. Cantini, D. Caratelli, B. Carlus, M. Carneiro, I. Caro Terrazas, T. J. Carroll, M. P. Carvallo, M. Cascella, C. Castromonte, E. Catano-Mur, M. Cavalli-Sforza, F. Cavanna, E. Cazzato, S. Centro, G. Cerati, A. Cervelli, A. Cervera Villanueva, T. Cervi, M. Chalifour, A. Chappuis, A. Chatterjee, S. Chattopadhyay, J. Chaves, H. Chen, M. -C. Chen, S. Chen, D. Cherdack, C. -Y. Chi, S. Childress, K. Cho, S. Choubey, B. C. Choudhary, A. Christensen, D. Christian, G. Christodoulou, C. -A. Christofferson, E. Church, P. Clarke, T. E. Coan, A. Cocco, G. H. Collin, E. Conley, J. M. Conrad, M. Convery, R. Corey, L. Corwin, P. Cotte, L. Cremonesi, J. I. Crespo-Anadón, J. Creus Prats, E. Cristaldo, P. Crivelli, D. Cronin-Hennessy, C. Crowley, C. Cuesta, A. Curioni, D. Cussans, M. Dabrowski, D. Dale, H. Da Motta, T. Davenne, E. Davenport, G. S. Davies, J. Davies, S. Davini, J. Dawson, K. De, M. P. Decowski, P. Dedin Neto, I. de Icaza Astiz, A. Delbart, D. Delepine, M. Delgado, A. Dell, J. de Mello Neto, D. DeMuth, Z. Deng, S. Dennis, C. Densham, I. De Bonis, A. De Gouvêa, P. De Jong, P. De Lurgio, S. De Rijck, A. De Roeck, J. J. de Vries, R. Dharmapalan, N. Dhingra, M. Diamantopoulou, F. Diaz, J. S. Díaz, G. Diaz Bautista, P. Ding, C. Distefano, M. Diwan, S. Di Domizio, L. Di Giulio, S. Di Luise, Z. Djurcic, F. Doizon, N. Dokania, M. J. Dolinski, R. Dong, J. dos Anjos, D. Douglas, G. Drake, D. Duchesneau, K. Duffy, B. Dung, D. Dutta, M. Duvernois, H. Duyang, O. Dvornikov, D. A. Dwyer, S. Dye, A. S. Dyshkant, S. Dytman, M. Eads, B. Eberly, D. Edmunds, J. Eisch, A. Elagin, S. Elliott, W. Ellsworth, M. Elnimr, S. Emery, S. Eno, A. Ereditato, C. O. Escobar, L. Escudero Sanchez, J. J. Evans, A. Ezeribe, K. Fahey, A. Falcone, L. Falk, A. Farbin, C. Farnese, Y. Farzan, M. Fasoli, A. Fava, J. Felix, E. Fernandez-Martinez, P. Fernandez Menendez, F. Ferraro, F. Feyzi, L. Fields, A. Filkins, F. Filthaut, A. Finch, O. Fischer, M. Fitton, R. Fitzpatrick, W. Flanagan, B. T. Fleming, R. Flight, T. Forest, J. Fowler, W. Fox, J. Franc, K. Francis, P. Franchini, D. Franco, J. Freeman, J. Freestone, J. Fried, A. Friedland, S. Fuess, I. Furic, A. Furmanski, A. M. Gago, H. Gallagher, A. Gallego-Ros, V. Galymov, E. Gamberini, S. Gambetta, T. Gamble, R. Gandhi, R. Gandrajula, S. Gao, D. Garcia-Gamez, S. Gardiner, D. Gastler, J. Gehrlein, B. Gelli, A. Gendotti, Z. Ghorbani-Moghaddam, A. Ghosh, D. Gibin, I. Gil-Botella, C. Girerd, A. K. Giri, S. Glavin, D. Goeldi, O. Gogota, M. Gold, S. Gollapinni, K. Gollwitzer, R. A. Gomes, L. Gomez, L. V. Gomez Bermeo, J. J. Gomez Cadenas, H. Gong, F. Gonnella, J. A. Gonzalez-Cuevas, M. Goodman, O. Goodwin, D. Gorbunov, S. Goswami, E. Goudzovski, C. Grace, N. Graf, M. Graham, E. Gramellini, R. Gran, A. Grant, C. Grant, N. Grant, V. Greco, S. Green, H. Greenlee, L. Greenler, M. Greenwood, J. Greer, W. C. Griffith, M. Groh, J. Grudzinski, K. Grzelak, G. Guanghua, E. Guardincerri, V. Guarino, G. P. Guedes, R. Guenette, A. Guglielmi, B. Guo, S. Gupta, V. Gupta, K. K. Guthikonda, R. Gutierrez, P. Guzowski, M. M. Guzzo, A. Habig, R. W. Hackenburg, A. Hackenburg, B. Hackett, H. Hadavand, R. Haenni, A. Hahn, J. Haigh, T. Haines, J. Haiston, T. Hamernik, P. Hamilton, J. Han, T. Handler, S. Hans, D. A. Harris, J. Hartnell, T. Hasegawa, R. Hatcher, A. Hatzikoutelis, S. Hays, E. Hazen, M. Headley, A. Heavey, K. Heegerv, J. Heise, K. Hennessy, S. Henry, A. Hernandez, J. Hernandez-Garcia, K. Herner, J. Hewes, J. Hignight, A. Higuera, T. Hill, S. Hillier, A. Himmel, C. Hohl, A. Holin, E. Hoppe, S. Horikawa, G. Horton-Smith, M. Hostert, A. Hourlier, B. Howard, R. Howell, J. Huang, J. Hugon, P. Hurh, J. Hylen, R. Illingworth, J. Insler, G. Introzzi, A. Ioannisian, A. Izmaylov, D. E. Jaffe, C. James, E. James, C. -H. Jang, F. Jediny, Y. S. Jeong, A. Jhingan, W. Ji, A. Jipa, S. Jiménez, C. Johnson, M. Johnson, R. Johnson, J. Johnstone, B. Jones, S. Jones, J. Joshi, H. Jostlein, C. K. Jung, T. Junk, A. Kaboth, I. Kadenko, F. Kamiya, Y. Kamyshkov, G. Karagiorgi, D. Karasavvas, Y. Karyotakis, S. Kasai, S. Kasetti, K. Kaur, B. Kayser, N. Kazaryan, E. Kearns, P. Keener, E. Kemp, C. Kendziora, W. Ketchum, S. H. Kettell, M. Khabibullin, A. Khotjantsev, D. Kim, B. Kirby, M. Kirby, J. Klein, Y. -J. Ko, T. Kobilarcik, B. Kocaman, L. W. Koerner, S. Kohn, G. Koizumi, P. Koller, A. Kopylov, M. Kordosky, L. Kormos, T. Kosc, U. Kose, V. A. Kostelecký, K. Kothekar, M. Kramer, F. Krennrich, I. Kreslo, K. Kriesel, W. Kropp, Y. Kudenko, V. A. Kudryavtsev, S. Kulagin, J. Kumar, L. Kumar, A. Kumar, S. Kumbhare, C. Kuruppu, V. Kus, T. Kutter, R. LaZur, K. Lande, C. Lane, K. Lang, T. Langford, F. Lanni, P. Lasorak, D. Last, C. Lastoria, A. Laundrie, I. Lazanu, T. Le, J. Learned, P. Lebrun, D. Lee, G. Lehmann Miotto, M. A. Leigui de Oliveira, Q. Li, S. Li, S. W. Li, X. Li, Y. Li, Z. Li, H. -Y. Liao, S. -K. Lin, C-J. S. Lin, R. Linehan, V. Linhart, J. Link, Z. Liptak, D. Lissauer, L. Littenberg, B. Littlejohn, J. Liu, T. Liu, L. LoMonaco, J. M. LoSecco, S. Lockwitz, N. Lockyer, T. Loew, M. Lokajicek, K. Long, K. Loo, J. P. Lopez, D. Lorca, T. Lord, M. Losada, W. C. Louis, M. Luethi, K. -B. Luk, T. Lundin, X. Luo, N. Lurkin, T. Lux, V. P. Luzio, J. Lykken, J. Maalampi, R. MacLellan, A. A. Machado, P. Machado, C. T. Macias, J. Macier, P. Madigan, S. Magill, G. Mahler, K. Mahn, M. Malek, J. A. Maloney, F. Mammoliti, S. K. Mandal, G. Mandrioli, L. Manenti, S. Manly, A. Mann, A. Marchionni, W. Marciano, S. Marcocci, D. Marfatia, C. Mariani, J. Maricic, F. Marinho, A. D. Marino, M. Marshak, C. Marshall, J. Marshall, J. Marteau, J. Martin-Albo, D. Martinez, N. Martinez, H. Martinez, K. Mason, A. Mastbaum, M. Masud, H. Mathez, S. Matsuno, J. Matthews, C. Mauger, N. Mauri, K. Mavrokoridis, R. Mazza, A. Mazzacane, E. Mazzucato, N. McCauley, E. McCluskey, N. McConkey, K. McDonald, K. S. McFarland, C. McGivern, A. McGowan, C. McGrew, R. McKeown, A. McNab, D. McNulty, R. McTaggart, V. Meddage, A. Mefodiev, P. Mehta, D. Mei, O. Mena, S. Menary, H. Mendez, D. P. Mendez, A. Menegolli, G. Meng, M. Messier, W. Metcalf, M. Mewes, H. Meyer, T. Miao, J. Migenda, R. Milincic, J. Miller, W. Miller, J. Mills, C. Milne, O. Mineev, O. Miranda, C. S. Mishra, S. R. Mishra, A. Mislivec, B. Mitrica, D. Mladenov, I. Mocioiu, K. Moffat, N. Moggi, R. Mohanta, N. Mokhov, J. Molina, L. Molina Bueno, A. Montanari, C. Montanari, D. Montanari, L. Montano Zetina, J. Moon, M. Mooney, C. Moore, D. Moreno, B. Morgan, G. F. Moroni, C. Morris, W. Morse, C. Mossey, C. A. Moura, J. Mousseau, L. Mualem, M. Muether, S. Mufson, F. Muheim, H. Muramatsu, S. Murphy, J. Musser, J. Nachtman, M. Nalbandyan, R. Nandakumar, D. Naples, S. Narita, G. Navarro, J. Navarro, D. Navas-Nicolás, N. Nayak, M. Nebot-Guinot, M. Needham, K. Negishi, J. Nelson, M. Nessi, D. Newbold, M. Newcomer, R. Nichol, T. C. Nicholls, E. Niner, A. Norman, B. Norris, J. Norris, P. Novella, E. Nowak, J. Nowak, M. S. Nunes, H. O'Keeffe, M. Oberling, A. Olivares Del Campo, A. Olivier, Y. Onel, Y. Onishchuk, T. Ovsjannikova, S. Ozturk, L. Pagani, S. Pakvasa, O. Palamara, J. Paley, M. Pallavicini, C. Palomares, J. Palomino, E. Pantic, A. Paolo, V. Paolone, V. Papadimitriou, R. Papaleo, S. Paramesvaran, J. Park, S. Parke, Z. Parsa, S. Pascoli, J. Pasternak, J. Pater, L. Patrizii, R. B. Patterson, S. J. Patton, T. Patzak, A. Paudel, B. Paulos, L. Paulucci, Z. Pavlovic, G. Pawloski, P. Payam, D. Payne, V. Pec, S. J. M. Peeters, E. Pennacchio, A. Penzo, G. N. Perdue, O. l. G. Peres, L. Periale, K. Petridis, G. Petrillo, R. Petti, P. Picchi, L. Pickering, F. Pietropaolo, J. Pillow, P. Plonski, R. Plunkett, R. Poling, X. Pons, N. Poonthottathil, M. Popovic, R. Pordes, S. Pordes, M. Potekhin, R. Potenza, B. Potukuchi, S. Poudel, J. Pozimski, M. Pozzato, T. Prakasj, R. Preece, O. Prokofiev, N. Pruthi, P. Przewlocki, F. Psihas, D. PugnËre, D. Pushka, K. Qi, X. Qian, J. L. Raaf, R. Raboanary, V. Radeka, J. Rademacker, V. Radescu, B. Radics, A. Radovic, A. Rafique, M. Rajaoalisoa, I. Rakhno, H. T. Rakotondramanana, L. Rakotondravohitra, Y. A. Ramachers, R. A. Rameika, M. A. Ramirez Delgado, J. Ramsey, B. J. Ramson, A. Rappoldi, G. L. Raselli, P. Ratoff, S. Ravat, O. Ravinez, H. Razafinime, B. Rebel, D. Redondo, C. Regenfus, M. Reggiani-Guzzo, T. Rehak, J. Reichenbacher, D. Reitzner, M. H. Reno, A. Renshaw, S. Rescia, F. Resnati, A. Reynolds, G. Riccobene, L. C. J. Rice, K. Rielage, K. Riesselmann, Y. -A. Rigaut, D. Rivera, L. Rochester, M. Roda, P. Rodrigues, M. J. Rodriguez Alonso, B. Roe, A. J. Roeth, R. M. Roser, M. Ross-Lonergan, M. Rossella, J. Rout, S. Roy, A. Rubbia, C. Rubbia, R. Rucinski, B. Russell, J. Russell, D. Ruterbories, M. R. Vagins, R. Saakyan, N. Sahu, P. Sala, G. Salukvadze, N. Samios, F. Sanchez, M. C. Sanchez, C. Sandoval, B. Sands, S. U. Sankar, S. Santana, L. M. Santos, G. Santucci, N. Saoulidou, P. Sapienza, C. Sarasty, I. Sarcevic, G. Savage, A. Scaramelli, A. Scarpelli, T. Schaffer, H. Schellman, P. Schlabach, C. M. Schloesser, D. W. Schmitz, J. Schneps, K. Scholberg, A. Schukraft, E. Segreto, S. Sehrawat, J. Sensenig, I. Seong, J. A. Sepulveda-Quiroz, A. Sergi, F. Sergiampietri, D. Sessumes, K. Sexton, L. Sexton-Kennedy, D. Sgalaberna, M. H. Shaevitz, S. Shafaq, J. S. Shahi, S. Shahsavarani, P. Shanahan, H. R. Sharma, R. Sharma, R. K. Sharma, T. Shaw, S. Shin, I. Shoemaker, D. Shooltz, R. Shrock, N. Simos, J. Sinclair, G. Sinev, V. Singh, J. Singh, I. Singh, R. Sipos, F. W. Sippach, G. Sirri, K. Siyeon, D. Smargianaki, A. Smith, E. Smith, P. Smith, J. Smolik, M. Smy, E. L. Snider, P. Snopok, J. Sobczyk, H. Sobel, M. Soderberg, C. J. Solano Salinas, S. Söldner-Rembold, N. Solomey, W. Sondheim, M. Sorel, J. A. Soto-Oton, A. Sousa, K. Soustruznik, F. Spagliardi, M. Spanu, J. Spitz, N. J. C. Spooner, R. Staley, M. Stancari, L. Stanco, A. Stefanik, H. M. Steiner, J. Stewart, J. Stock, F. Stocker, S. Stoica, J. Stone, J. Strait, M. Strait, T. Strauss, S. Striganov, A. Stuart, G. Sullivan, M. Sultana, Y. Sun, A. Surdo, V. Susic, L. Suter, C. M. Sutera, R. Svoboda, B. Szczerbinska, A. M. Szelc, N. Tagg, R. Talaga, H. Tanaka, B. Tapia Oregui, S. Tariq, E. Tatar, R. Tayloe, M. Tenti, K. Terao, C. A. Ternes, F. Terranova, G. Testera, A. Thea, L. F. Thompson, J. Thompson, C. Thorn, A. Timilsina, S. C. Timm, J. Todd, A. Tonazzo, T. Tope, D. Torbunov, M. Torti, M. Tórtola, F. Tortorici, M. Toups, C. Touramanis, J. Trevor, M. Tripathi, W. Tromeur, I. Tropin, W. H. Trzaska, Y. -T. Tsai, K. V. Tsang, A. Tsaris, S. Tufanli, C. Tull, J. Turner, M. Tzanov, E. Tziaferi, Y. Uchida, J. Urheim, T. Usher, G. A. Valdiviesso, E. Valencia, L. Valerio, Z. Vallari, J. W. F. Valle, R. Van Berg, R. Van de Water, F. Varanini, G. Varner, J. Vasel, G. Vasseur, K. Vaziri, G. Velev, S. Ventura, A. Verdugo, M. Vermeulen, E. Vernon, M. Verzocchi, T. Viant, C. Vignoli, S. Vihonen, C. Vilela, B. Viren, P. Vokac, T. Vrba, T. Wachala, D. Wahl, M. Wallbank, H. Wang, J. Wang, T. -C. Wang, B. Wang, Y. Wang, Z. Wang, K. Warburton, D. Warner, M. O. Wascko, D. Waters, A. Watson, A. Weber, M. Weber, H. Wei, W. Wei, A. Weinstein, D. Wenman, M. Wetstein, M. While, A. White, L. H. Whitehead, D. Whittington, K. Wierman, M. Wilking, C. Wilkinson, J. Willhite, Z. Williams, R. J. Wilson, P. Wilson, P. Wittich, J. Wolcott, T. Wongjirad, K. Wood, L. Wood, E. Worcester, M. Worcester, S. Wu, W. Wu, W. Xu, C. Yanagisawa, S. Yang, T. Yang, G. Yang, J. Ye, M. Yeh, N. Yershov, K. Yonehara, L. Yoshimura, B. Yu, J. Yu, J. Zalesak, L. Zambelli, B. Zamorano, A. Zani, K. Zaremba, L. Zazueta, G. P. Zeller, J. Zennamo, C. Zhang, M. Zhao, Y. -L. Zhou, G. Zhu, E. D. Zimmerman, M. Zito, S. Zucchelli, J. Zuklin, V. Zutshi, and R. Zwaska

Abstract

The DUNE IDR describes the proposed physics program and technical designs of the DUNE Far Detector modules in preparation for the full TDR to be published in 2019. It is intended as an intermediate milestone on the path to a full TDR, justifying the technical choices that flow down from the high-level physics goals through requirements at all levels of the Project. These design choices will enable the DUNE experiment to make the ground-breaking discoveries that will help to answer fundamental physics questions. Volume 1 contains an executive summary that describes the general aims of this document. The remainder of this first volume provides a more detailed description of the DUNE physics program that drives the choice of detector technologies. It also includes concise outlines of two overarching systems that have not yet evolved to consortium structures: computing and calibration. Volumes 2 and 3 of this IDR describe, for the single-phase and dual-phase technologies, respectively, each detector module's subsystems, the technical coordination required for its design, construction, installation, and integration, and its organizational structure.

Published
2018

33. Short Interfering RNA against Bax Attenuates TNFα‐Induced Ototoxicity in Rat Organ of Corti Explants

Author

Ly Vu, Christine T. Dinh, Esperanza Bas, Thomas R. Van De Water, John Dinh, and Chhavi Gupta

Subjects
Programmed cell death, Small interfering RNA, Cell Survival, Gene Expression, Apoptosis, Biology, Immunofluorescence, Rats, Sprague-Dawley, Ototoxicity, Hair Cells, Auditory, medicine, Animals, RNA, Small Interfering, Hearing Loss, Organ of Corti, bcl-2-Associated X Protein, medicine.diagnostic_test, Tumor Necrosis Factor-alpha, medicine.disease, Molecular biology, In vitro, Rats, Disease Models, Animal, medicine.anatomical_structure, Otorhinolaryngology, Surgery, Tumor necrosis factor alpha
Abstract

Evaluate the effectiveness of short interfering RNA against Bax (Bax siRNA) as a treatment for tumor necrosis factor α (TNFα)-induced auditory hair cell (HC) loss in rat organ of Corti (OC) explants.Basic science.Basic science laboratory, University of Miami Ear Institute.Organ of Corti explants dissected from 3-day-old rats were cultured in control media, TNFα, and TNFα + Bax siRNA at 0, 48, and 72 hours in vitro. Real-time polymerase chain reaction, enzyme-linked immunosorbent assay, HC viability studies, immunofluorescence, and confocal microscopy were performed. Analysis of variance with post hoc testing was used with P.05 considered significant.The TNFα-damaged explants demonstrated significant decreases in viable HCs in the basal turn with corresponding increased levels of Bax gene and protein expression, compared with control explant levels. The levels of viable HCs and Bax gene and protein expression in TNFα + Bax siRNA-treated explants approached levels measured in control explants. Immunolocalization studies showed increased Bax protein expression in basal turn HCs in TNFα-treated explants, whereas control explants and TNFα + Bax siRNA-treated explants had low levels of Bax expression.TNFα initiates the programmed cell death of auditory HCs in OC explants through upregulation of proapoptotic Bax gene and protein expression. Bax siRNA blocks TNFα-induced apoptosis of HCs by decreasing the TNFα-induced levels of Bax mRNA and protein expression in treated explants. Bax siRNA is an effective treatment for TNFα-induced ototoxicity in OC explants in vitro and has great potential to be a therapeutic agent against trauma/inflammation-induced hearing loss.

Published
2013
Full Text
View/download PDF

34. A novel combination of drug therapy to protect residual hearing post cochlear implant surgery

Author

Blake Bauer, Adrien A. Eshraghi, Fred F. Telischi, Mateo Guardiola, Esperanza Bas, Ileana Rivera, Jonathan Roell, Jeenu Mittal, Noah Shaikh, and Thomas R. Van De Water

Subjects
Programmed cell death, medicine.medical_specialty, Hearing loss, medicine.medical_treatment, Anti-Inflammatory Agents, Dexamethasone, Acetylcysteine, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Cochlear implant, Hair Cells, Auditory, otorhinolaryngologic diseases, medicine, Animals, Inner ear, Mannitol, 030223 otorhinolaryngology, Hearing Loss, Cochlea, business.industry, General Medicine, Free Radical Scavengers, Cochlear Implantation, Surgery, medicine.anatomical_structure, Otorhinolaryngology, Apoptosis, Anesthesia, Drug Therapy, Combination, sense organs, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Conclusions A cocktail combining NAC, Mannitol, and Dexamethasone may be used to prevent loss of residual hearing post-implantation. There is a window of opportunity to treat the cochlea before the onset of cell death in HCs. Objective Inner ear trauma caused by cochlear implant electrode insertion trauma (EIT) initiates multiple molecular mechanisms in hair cells (HCs) or support cells (SCs), resulting in initiation of programmed cell death within the damaged tissues of the cochlea, which leads to loss of residual hearing. In earlier studies L-N-acetylcysteine (L-NAC), Mannitol, and dexamethasone have been shown independently to protect the HCs loss against different types of inner ear trauma. These three molecules have different otoprotective effects. The goal of this preliminary study is to test the efficacy of a combination of these molecules to enhance the otoprotection of HCs against EIT. Methods OC explants were dissected from P-3 rats and placed in serum-free media. Explants were divided into control and experimental groups.(1) untreated controls; (2) EIT. Experimental group: (1) EIT + L-NAC (5, 2, or 1 mM); (2) EIT + Mannitol (100, 50, or 10 mM); (3) EIT + Dex (20, 10, or 5 μg/mL); (4) EIT + L-NAC + Mannitol + Dex. After EIT was caused in an in-vitro model of CI, explants were cultured in media containing L-NAC alone, Mannitol alone, or Dex alone at decreasing concentrations. Concentrations of L-NAC, Mannitol, and Dex that showed 50% protection of hair cell loss individually were used as a combination in experimental group 4. Results There was an increase of total hair cell (THC) loss in the EIT OC explants when compared with control group HC counts or the tri-therapy cochlea. This study defined the dosage of L-NAC, Mannitol, and Dex for the survival of 50% protection of hair cells in vitro. Their combination provided close to 96% protection, demonstrating an additive effect.

Published
2016

35. Mannitol Protects Hair Cells Against Tumor Necrosis Factor α–Induced Loss

Author

Adrien A. Eshraghi, Esperanza Bas Infante, Ly Vu, John Dinh, Chhavi Gupta, Fred F. Telischi, Thomas R. Van De Water, and Guyan A. Channer

Subjects
Tissue Fixation, Cell Survival, Hearing loss, Fluorescent Antibody Technique, Apoptosis, Auditory Hair Cell, Ototoxicity, Hair Cells, Auditory, otorhinolaryngologic diseases, medicine, Animals, Mannitol, Inner ear, Coloring Agents, Organ of Corti, Tumor necrosis factor α, Organ system, Microscopy, Confocal, Tumor Necrosis Factor-alpha, business.industry, medicine.disease, Sensory Systems, Rats, Neuroprotective Agents, medicine.anatomical_structure, Otorhinolaryngology, Anesthesia, Cancer research, Tumor necrosis factor alpha, Neurology (clinical), medicine.symptom, business, medicine.drug
Abstract

Mannitol has otoprotective effects against tumor necrosis factor (TNF) α-induced auditory hair cell (HC) loss.Mannitol has been demonstrated to possess cytoprotective effects in several organ systems. Its protective effect on postischemic hearing loss has also been shown. Mannitol's otoprotective mechanism and site of action are at present unknown.Organ of Corti (OC) explants were dissected from 3 day-old rat pups. The safety (nonototoxicity) of mannitol was assessed at 4 different concentrations (1-100 mM). Three experimental arms were designed including: a control group, TNFα group, and TNFα + mannitol group. Cell viability was determined by counts of fluorescein isothiocyanate (FITC) phalloidin stained HC. Immunofluorescence assay of phospho-c-Jun and the proapoptotic mediators, cleaved caspase-3, apoptosis inducing factor (AIF), and endonuclease G (Endo G) were performed.Analysis of HC density confirmed the safety of mannitol at concentration ranges of 1 to 100 mM. The ototoxic effect of TNFα was demonstrated (p0.05). The otoprotective effect of 100 mM mannitol in TNFα-challenged OC explants was also demonstrated (p0.001). Mannitol treatment reduced the high levels of phospho-c-Jun observed in the TNFα-challenged group. AIF cluster formation and EndoG translocation into the nuclei of HCs were also reduced by mannitol treatment.Mannitol significantly reduces the ototoxic effects of TNFα against auditory HC's potentially by inhibiting c-Jun N terminal kinase (JNK) activation pathway and AIF, EndoG nuclear translocation. This local otoprotective effect may have therapeutic implications in inner ear surgery, for example, cochlear implants, protection of residual hearing, as well as implications for postischemic inner ear insults.

Published
2012
Full Text
View/download PDF

36. Historical Aspects of Inner Ear Anatomy and Biology that Underlie the Design of Hearing and Balance Prosthetic Devices

Author

Thomas R. Van De Water

Subjects
medicine.medical_specialty, Histology, History, Sensory system, Audiology, Biology, History, 21st Century, Prosthesis Implantation, Animal model, Sensory Functions, otorhinolaryngologic diseases, medicine, Animals, Humans, Inner ear, Hearing Loss, Auditory Brain Stem Implants, Ecology, Evolution, Behavior and Systematics, Balance (ability), Balance disorders, Anatomy, History, 20th Century, medicine.anatomical_structure, Ear, Inner, Vertigo, Hearing impaired, Biotechnology
Abstract

This review presents some of the major historical events that advanced the body of knowledge of the anatomy of the inner ear and its sensory receptors as well as the biology of these receptors that underlies the sensory functions of hearing and balance. This knowledge base of the inner ear's structure/function has been an essential factor for the design and construction of prosthetic devices to aid patients with deficits in their senses of hearing and balance. Prosthetic devices are now available for severely hearing impaired and deaf patients to restore hearing and are known as cochlear implants and auditory brain stem implants. A prosthetic device for patients with balance disorders is being perfected and is in an animal model testing phase with another prosthetic device for controlling intractable dizziness in Meniere's patients currently being evaluated in clinical testing. None of this would have been possible without the pioneering studies and discoveries of the investigators mentioned in this review and with the work of many other talented investigators to numerous to be covered in this review.

Published
2012
Full Text
View/download PDF

37. Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses

Author

Jaime Marco, Ly Vu, JM Láinez, T. R. Van De Water, Chhavi Gupta, John Dinh, Esperanza Bas, and F Martinez-Soriano

Subjects
Pharmacology, medicine.medical_specialty, Aminoglycoside, Biology, medicine.disease_cause, medicine.disease, Melatonin, medicine.anatomical_structure, Endocrinology, Ototoxicity, Organ of Corti, Apoptosis, Internal medicine, medicine, Hair cell, Dexamethasone, Oxidative stress, medicine.drug
Abstract

BACKGROUND AND PURPOSE Exposure to an ototoxic level of an aminoglycoside can result in hearing loss. In this we study investigated the otoprotective efficacy of dexamethasone (DXM), melatonin (MLT) and tacrolimus (TCR) in gentamicin (GM)-treated animals and cultures. EXPERIMENTAL APPROACH Wistar rats were divided into controls (treated with saline); exposed to GM only (GM); and three GM-exposed groups treated with either DXM, MLT or TCR. Auditory function and cochlear surface preparations were studied. In vitro studies of oxidative stress, pro-inflammatory cytokine mRNA levels, the MAPK pathway and caspase-3 activation were performed in organ of Corti explants from 3-day-old rats. KEY RESULTS DXM, MLT and TCR decreased levels of reactive oxygen species in GM-exposed explants. The mRNA levels of TNF-α, IL-1β and TNF-receptor type 1 were significantly reduced in GM + DXM and GM + MLT groups. Phospho-p38 MAPK levels decreased in GM + MLT and GM + TCR groups, while JNK phosphorylation was reduced in GM + DXM and GM + MLT groups. Caspase-3 activation decreased in GM + DXM, GM + MLT and GM + TCR groups. These results were consistent with in vivo results. Local treatment of GM-exposed rat cochleae with either DXM, MLT or TCR preserved auditory function and prevented auditory hair cell loss. CONCLUSIONS AND IMPLICATIONS In organ of Corti explants, GM increased oxidative stress and initiated an inflammatory response that led to the activation of MAPKs and apoptosis of hair cells. The three compounds tested demonstrated otoprotective properties that could be beneficial in the treatment of ototoxicity-induced hearing loss.

Published
2012
Full Text
View/download PDF

38. Local drug delivery for inner ear therapy

Author

Dana R. Libman, Thomas R. Van De Water, and Enrique Perez

Subjects
Drug, medicine.medical_specialty, Round window, business.industry, Hearing loss, media_common.quotation_subject, Audiology, medicine.disease, Speech and Hearing, medicine.anatomical_structure, Ototoxicity, Drug delivery, otorhinolaryngologic diseases, Medicine, Inner ear, sense organs, medicine.symptom, business, Cochlear implantation, Cochlea, media_common
Abstract

This review of local drug delivery for inner ear therapy covers the topics of: noise-induced hearing loss (NIHL); vibration-induced hearing loss (VHL); cisplatin ototoxicity; aminoglycoside ototoxicity; and mechanical trauma-induced hearing loss that can occur during the process of cochlear implantation. The cellular, biochemical and molecular mechanisms involved in the causation of the hearing losses that result from exposure to these diverse traumas to the cochlea and its auditory sensory epithelium are explored as well as the efficacy of different drug therapies in their ability to either prevent or lessen the damage to the cochlear sensory epithelium and ameliorate the level of hearing loss. This review concludes with a section that explores future strategies for unique methods of drug delivery to the cochlea (e.g. biorelease from hydrogels via the round window membrane) and the development of novel inner ear therapies (e.g. short interfering ribonucleic acids, siRNAs) to conserve hearing against trau...

Published
2012
Full Text
View/download PDF

39. Middle Ear Packing

Author

Ralph Abi-Hachem, Michael Julian Lipan, Stephen E. Vernon, Thomas R. Van De Water, Ibrahim Alava, and Simon I. Angeli

Subjects
medicine.medical_specialty, Guinea Pigs, Ear, Middle, Biocompatible Materials, Hemostatics, Injections, Guinea pig, chemistry.chemical_compound, Animal model, Hyaluronic acid, otorhinolaryngologic diseases, medicine, Animals, Hyaluronic Acid, Tympanic Membrane Perforation, Absorbable gelatin sponge, Mucous Membrane, business.industry, Gelatin Sponge, Absorbable, Surgery, Auditory brainstem response, medicine.anatomical_structure, Otorhinolaryngology, chemistry, Middle ear surgery, Models, Animal, Middle ear, Female, business
Abstract

To compare absorbable gelatin sponge (AGS) with an injectable esterified hyaluronic acid (EHA) as middle ear packing material after mucosal trauma.Randomized, blinded, and controlled study.Tertiary university-based hospital.Twenty-three guinea pigs underwent middle ear surgery with mucosal trauma performed on both ears and one ear packed with either EHA or AGS. Contralateral ears were used as nonpacked paired controls. Auditory brainstem response (ABR) thresholds were measured preoperatively and repeated at 1, 2, and 6 weeks postoperatively. Macroscopic and microscopic analysis measured inflammatory reaction in each group.ABR threshold changes from baseline in the EHA and both control groups were minor. Threshold levels were higher in the AGS group compared with the AGS control group. This trend was seen in each frequency tested at each time interval. Macroscopic analysis showed tympanic membrane perforation was rare, effusions were common in the AGS group, mucosal edema was most frequent in the AGS group, and unabsorbed packing was usually detected in the AGS group with little EHA detectable at 6 weeks. Microscopic analysis showed normal mucosal healing in all groups. Two AGS ears demonstrated excessive middle ear packing with exuberant osteoneogenesis.Middle ear function and mucosal healing after surgery occurred similarly between the EHA control group and the EHA group. In contrast, the AGS group demonstrated worse hearing and a greater level of osteoneogenesis compared with the AGS control group. These results support EHA as an alternative middle ear packing material in otologic surgery.

Published
2011
Full Text
View/download PDF

40. The Injured Cochlea as a Target for Inflammatory Processes, Initiation of Cell Death Pathways and Application of Related Otoprotective Strategies

Author

Thomas R. Van De Water, Azel Zine, and Ralph Abi-Hachem

Subjects
medicine.medical_specialty, Programmed cell death, Cochlear Diseases, MAP Kinase Signaling System, Hearing loss, Audiology, Biology, medicine.disease_cause, Models, Biological, Antioxidants, Drug Delivery Systems, Ototoxicity, Adrenal Cortex Hormones, Hair Cells, Auditory, Drug Discovery, otorhinolaryngologic diseases, medicine, Animals, Humans, Pharmacology (medical), Hearing Loss, Cochlea, Inflammation, Cell Death, JNK Mitogen-Activated Protein Kinases, medicine.disease, Caspase Inhibitors, Psychiatry and Mental health, Neuroprotective Agents, medicine.anatomical_structure, Organ of Corti, Cancer research, Sensorineural hearing loss, sense organs, medicine.symptom, Reperfusion injury, Oxidative stress, Signal Transduction
Abstract

One of the causes of sensorineural hearing loss is the loss of auditory hair cells following exposure to environmental stresses. Auditory hair cell death in response to cochlear trauma occurs via both necrosis and apoptosis. Apoptosis of hair cells involves the caspase and MAPK/JNK pathways which are activated by oxidative stress and secretion of inflammatory cytokines in response to trauma. Identification of the pathways that lead to apoptosis provides therapeutic targets for the conservation of hearing. Antioxidants reduce the level of reactive oxygen species and reactive nitrogen species generated by oxidative stress in response to acoustic trauma, aminoglycoside and platinum-based drugs. Caspase inhibitors affect both the extrinsic and intrinsic apoptotic pathways thereby reducing cisplatin, aminoglycoside, hydraulic trauma and ischemia-induced hearing losses. Corticosteroid therapy reduces inflammation and inhibits apoptosis while activating pro-survival pathways in the organ of Corti following exposure to noise, vibration, cisplatin, aminoglycoside, ischemia/reperfusion injury, bacterial meningitis and electrode insertion trauma. Inhibitors of JNK signaling pathway prevent apoptosis of auditory hair cells following electrode insertion trauma, acute labyrinthitis, acoustic trauma and aminoglycoside ototoxicity. This review provides an overview of the different pathways involved in auditory hair cell death following an environmental stress and both traditional and newly developed drugs that are currently being studied or used for the treatment of acute hearing loss. Recent patents related to otoprotective strategies to conserve hearing and auditory hair cells are also discussed in this review.

Published
2010
Full Text
View/download PDF

41. Mechanisms of hearing loss from trauma and inflammation: otoprotective therapies from the laboratory to the clinic

Author

Christine T. Dinh, Gia Hoosien, Adrien A. Eshraghi, Thomas R. Van De Water, Richard J. Vivero, and Thomas J. Balkany

Subjects
medicine.drug_class, Hearing loss, Administration, Topical, medicine.medical_treatment, Guinea Pigs, Anti-Inflammatory Agents, Gene Expression, Apoptosis, Cell Count, Deafness, In Vitro Techniques, Pharmacology, Dexamethasone, In vivo, Cochlear implant, Hair Cells, Auditory, otorhinolaryngologic diseases, medicine, Animals, Humans, Organ of Corti, bcl-2-Associated X Protein, medicine.diagnostic_test, Tumor Necrosis Factor-alpha, business.industry, Auditory Threshold, General Medicine, Scala Tympani, Cochlear Implantation, Electrodes, Implanted, Rats, Disease Models, Animal, medicine.anatomical_structure, Proto-Oncogene Proteins c-bcl-2, Otorhinolaryngology, Immunology, Audiometry, Pure-Tone, Cytokines, Corticosteroid, sense organs, Hair cell, Inflammation Mediators, Audiometry, medicine.symptom, business, medicine.drug
Abstract

This article reviews a series of in vitro and in vivo studies that examined the otoprotective efficacy of locally delivered dexamethasone and explored the mechanisms by which dexamethasone protects auditory hair cells. These studies used auditory threshold testing in response to pure tone stimuli, organ of Corti explant cultures, FITC-phalloidin-stained explants, and surface preparations to determine hair cell density, osmotic pump delivery of dexamethasone into the scala tympani, an animal model of electrode insertion trauma (EIT)-induced hearing loss, and real-time RT-PCR studies of gene expression levels. Local delivery of two different formulations of dexamethasone conserved hearing and protected hair cells in an animal model of cochlear implantation. Dexamethasone treatment protected hair cells in organ of Corti explants exposed to an ototoxic level of an inflammatory cytokine, and gene expression studies showed that this protection was accomplished by increased expression levels of anti-apoptosis genes (e.g. Bcl-2) and decreased levels of pro-apoptosis genes (e.g. Bax). We conclude that dexamethasone is an effective otoprotective drug for both the conservation of hearing and preservation of hair cells against trauma-induced losses. Locally delivered dexamethasone is a promising therapeutic approach for the conservation of hearing during the process of cochlear implantation.

Published
2009
Full Text
View/download PDF

42. Contents Vol. 14, 2009

Author

Kimanh D. Nguyen, Andrew Chang, Michael J. McKenna, Jeffrey P. Harris, Luis A. Dellamary, Rachael T. Richardson, Amanda Hu, Sangeeta Maini, Carl Lebel, Halina Lisnichuk, Lloyd B. Minor, Dennis R. Trune, Thomas R. Van De Water, Hayden Eastwood, Erin E. Leary Swan, Anne Harrop, Xiaobo Wang, David Sly, Sarah L. Tao, Jason O. Fiering, Jay Lichter, Charles C. Della Santina, John P. Carey, Alec N. Salt, William F. Sewell, Stefan K. Plontke, Fabrice Piu, Darren Pinder, Sharon G. Kujawa, Elizabeth M. Keithley, Mark M. Mescher, David E. James, Stephen O'Leary, Tim Connolly, Ophir Handzel, J. Beth Kempton, Marcello Peppi, Zhiqiang Chen, Jeffrey T. Borenstein, Maria Holmboe, Gordana Kel, Ernest S. Kim, Qiang Ye, Lorne S. Parnes, Rayne Fernandez, Christine T. Dinh, and Brian R. Murphy

Subjects
Speech and Hearing, medicine.medical_specialty, Otorhinolaryngology, Physiology, Philosophy, medicine, Audiology, Sensory Systems
Published
2009
Full Text
View/download PDF

43. Blocking Pro-Cell-Death Signal Pathways to Conserve Hearing

Author

Thomas R. Van De Water and Christine T. Dinh

Subjects
MAPK/ERK pathway, Programmed cell death, Physiology, Hearing loss, Apoptosis, Pharmacology, Antioxidants, Speech and Hearing, Hearing, Adrenal Cortex Hormones, Hair Cells, Auditory, otorhinolaryngologic diseases, medicine, Animals, Humans, Hearing Loss, Protein kinase A, Organ of Corti, Cochlea, Inflammation, business.industry, Kinase, medicine.disease, Sensory Systems, Otorhinolaryngology, Immunology, Cytokines, Sensorineural hearing loss, Animal studies, medicine.symptom, Reactive Oxygen Species, business, Signal Transduction
Abstract

The programmed cell death of stress-damaged auditory hair cells can occur through a variety of signal pathways, and therapeutic modalities that block pro-cell-death pathways are being developed and evaluated for hearing preservation. Because of their ability to have both anti-inflammatory and anti-apoptotic actions, corticosteroids have long been used to protect against several types of acute sensorineural hearing loss. Other anti-apoptotic drugs that target the mitogen-activated protein kinase (MAPK)/c-Jun-N terminal kinase (JNK) signal cascade, such as D-JNKI-1 (AM-111) and SP600125, have produced promising results both in vitro and in laboratory animal studies, with AM-111 showing promise in preliminary clinical trials. Antioxidant drugs, e.g. sodium thiosulfate, N-acetylcysteine, and D-methionine, have been shown in animal studies to attenuate permanent threshold shifts in hearing by reducing oxidative stress. In addition to reviewing selected therapeutic trends for the conservation of hearing, we review our experiences with dexamethasone and D-JNKI-1 and report results from our current research.

Published
2009
Full Text
View/download PDF

44. Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha–induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes

Author

Christine T. Dinh, Scott M. Haake, T. R. Van De Water, Kimberly Hoang, Adrien A. Eshraghi, Shibing Chen, Th.J. Balkany, and E. Nong

Subjects
Programmed cell death, Pathology, medicine.medical_specialty, Time Factors, bcl-X Protein, Gene Expression, Apoptosis, Biology, Dexamethasone, Rats, Sprague-Dawley, Andrology, Organ Culture Techniques, Ototoxicity, Hair Cells, Auditory, Gene expression, medicine, Animals, Glucocorticoids, Organ of Corti, Cochlea, bcl-2-Associated X Protein, Analysis of Variance, Tumor Necrosis Factor-alpha, General Neuroscience, medicine.disease, Rats, medicine.anatomical_structure, Animals, Newborn, Proto-Oncogene Proteins c-bcl-2, Receptors, Tumor Necrosis Factor, Type I, Tumor necrosis factor alpha, Hair cell, medicine.drug
Abstract

Objective: Determine the molecular mechanism(s) behind tumor necrosis factor-alpha (TNFα)–induced loss of auditory hair cells and the ability of dexamethasone base (DXMb) to protect against TNFα ototoxicity. Methods: Hair cell counts: Three-day-old rat organ of Corti explants were cultured under three different conditions: 1) untreated-control; 2) TNFα (2 μg/ml); and 3) TNFα (2 μg/ml)+DXMb (70 μg/ml) for 4 days, fixed, and stained with FITC–phalloidin. Hair cells were counted in the basal and middle turns. Gene expression: total RNA was extracted from the three different groups of explants at 0, 12, 24 and 48 h. Using quantitative real-time RT-PCR, mRNAs were transcribed into cDNAs and amplification was performed using primers for rat s-actin (housekeeping gene), TNFR1, Bcl-2, Bax, and Bcl-xl. Results: DXMb protected explant hair cells from TNFα-induced loss. Bax gene expression was greater in TNFα-exposed explants compared with TNFα+DXMb-treated explants at 48 h (P=0.023), confirmed by the increase in the Bax/Bcl-2 ratio at 48 h (P

Published
2008
Full Text
View/download PDF

45. Local Dexamethasone Therapy Conserves Hearing in an Animal Model of Electrode Insertion Trauma-Induced Hearing Loss

Author

Reid Graves, Eelam Adil, Adrien A. Eshraghi, Thomas R. Van De Water, Jiao He, and Thomas J. Balkany

Subjects
medicine.medical_specialty, Hearing loss, medicine.medical_treatment, Guinea Pigs, Anti-Inflammatory Agents, Audiology, Two stages, Dexamethasone, Electrode insertion, Animal model, Cochlear implant, otorhinolaryngologic diseases, medicine, Animals, Hearing Loss, Cochlear implantation, medicine.diagnostic_test, business.industry, Infusion Pumps, Implantable, Scala Tympani, Cochlear Implantation, Sensory Systems, Cochlea, Electrodes, Implanted, Cochlear Implants, Otorhinolaryngology, Audiometry, Pure-Tone, Neurology (clinical), medicine.symptom, Audiometry, business, medicine.drug
Abstract

The progressive loss of hearing that develops after electrode insertion trauma (EIT) can be attenuated by local dexamethasone (DXM) therapy.Hearing loss (HL) that develops after cochlear implant EIT occurs in two stages in laboratory animals, that is, an immediate loss followed by a progressive loss. Direct infusion of DXM into the guinea pig cochlea can attenuate both ototoxin- and noise-induced HL.Auditory-evoked brainstem responses (ABRs) of guinea pigs were measured for 4 frequencies (i.e., 0.5, 1, 4, and 16 kHz) before, immediately after, and more than 30 days post-EIT for experimental (EIT,EIT + artificial perilymph, and EIT + DXM) and for the contralateral unoperated cochleae of each group. An electrode analog of 0.14-mm diameter was inserted through a basal turn cochleostomy for a depth of 3 mm and withdrawn. DXM in artificial perilymph was delivered immediately post-EIT into the scala tympani via a miniosmotic pump for 8 days.The ABR thresholds of EIT animals increased progressively post-EIT. Contralateral unoperated cochleae had no significant changes in ABR thresholds. Immediately post-EIT, that is, Day 0, the DXM-treated animals exhibited a significant HL at 1, 4, and 16 kHz, but this HL was no longer significant by Day 30 compared with contralateral control ears.The results from immediate local treatment of the cochlea with DXM in an animal model of EIT-induced HL suggest a novel therapeutic strategy for hearing conservation by attenuating the progressive HL that can result from the process of electrode array insertion during cochlear implantation.

Published
2007
Full Text
View/download PDF

46. Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity

Author

Jing Wang, Jean-Luc Puel, Azel Zine, Eelam Adil, Thomas R. Van De Water, Jiao He, Christophe Bonny, Thomas J. Balkany, Adrien A. Eshraghi, Michael Bublik, Hamel, Christian, Cochlear Implant Research Program, Department of Otolaryngology, University of Miami Leonard M. Miller School of Medicine (UMMSM), Physiopathologie et thérapie des déficits sensoriels et moteurs, Université Montpellier 2 - Sciences et Techniques (UM2)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Lausanne = University of Lausanne (UNIL)

Subjects
MESH: Signal Transduction, medicine.medical_specialty, Free Radicals, MAP Kinase Signaling System, Hearing loss, Guinea Pigs, MESH: Neomycin, Apoptosis, Pharmacology, MESH: Guinea Pigs, MESH: Free Radicals, Ototoxicity, MESH: Anti-Bacterial Agents, otorhinolaryngologic diseases, Animals, Medicine, MESH: Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Hearing Loss, MESH: Hearing Loss, Electrodes, Cochlea, MESH: Caspases, biology, MESH: Peptides, MESH: MAP Kinase Signaling System, business.industry, MESH: Apoptosis, Aminoglycoside, c-jun, JNK Mitogen-Activated Protein Kinases, Neomycin, MESH: Electrodes, MESH: JNK Mitogen-Activated Protein Kinases, medicine.disease, Sensory Systems, Anti-Bacterial Agents, Surgery, Caspases, Mitogen-activated protein kinase, biology.protein, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Signal transduction, medicine.symptom, Peptides, business, Signal Transduction, medicine.drug
Abstract

International audience; Neomycin ototoxicity and electrode insertion trauma both involve activation of the mitogen activated protein kinase (MAPK)/c-Jun-N-terminal kinase (JNK) cell death signal cascade. This article discusses mechanisms of cell death on a cell biology level (e.g. necrosis and apoptosis) and proposes the blocking of JNK signaling as a therapeutic approach for preventing the development of a permanent hearing loss that can be initiated by either neomycin ototoxicity or electrode insertion trauma. Blocking of JNK molecules incorporates the use of a peptide inhibitor (i.e. D-JNKI-1), which is specific for all three isoforms of JNK and has been demonstrated to prevent loss of hearing following either electrode insertion trauma or loss of both hearing and hair cells following exposure to an ototoxic level of neomycin. We present previously unpublished results that control for the effect of perfusate washout of aminoglycoside antibiotic by perfusion of the scala tympani with an inactive form of D-JNKI-1 peptide, i.e. JNKI-1(mut) peptide, which was not presented in the original J. Neurosci. article that tested locally delivered D-JNKI-1 peptide against both noise- and neomycin-induced hearing loss (i.e. Wang, J., Van De Water, T.R., Bonny, C., de Ribaupierre, F., Puel, J.L., Zine, A. 2003a. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J. Neurosci. 23, 8596-8607). D-JNKI-1 is a cell permeable peptide that blocks JNK signaling at the level of the three JNK molecular isoforms, which when blocked prevents the increases in hearing thresholds and the loss of auditory hair cells. This unique therapeutic approach may have clinical application for preventing: (1) hearing loss caused by neomycin ototoxicity; and (2) the progressive component of electrode insertion trauma-induced hearing loss.

Published
2007
Full Text
View/download PDF

47. Induction of localized cochlear hypothermia

Author

Adrien A. Eshraghi, Thomas R. Van De Water, Lee P. Smith, Douglas E. Whitley, and Thomas J. Balkany

Subjects
Neurons, Cell Survival, Hearing loss, business.industry, medicine.medical_treatment, Rat model, General Medicine, Hypothermia, Cochlear Implantation, Rats, Inbred F344, Cochlea, Rats, Otorhinolaryngology, Hypothermia, Induced, Cochlear implant, Anesthesia, otorhinolaryngologic diseases, medicine, Animals, sense organs, medicine.symptom, Cochlear implantation, business, Body Temperature Regulation
Abstract

Localized cochlear hypothermia was induced in a rat model, demonstrating the feasibility of modulating cochlear temperature without affecting core body temperature.Systemic hypothermia has been demonstrated to protect the rat cochlea against electrode insertion trauma-induced hearing loss. Due to potential adverse effects of systemic hypothermia, we set out to demonstrate the feasibility of inducing localized cochlear hypothermia and compared the efficacy of three cooling techniques.Twenty-four ears were prepared by sealing a temperature micro-probe into the basal turn of the cochlea. Cochleae were then cooled by cold saline irrigation of the external auditory canal (EAC) or bulla or by direct application of ice over the bulla. Cochlear temperature measurements were recorded every 30 s during the cooling period until stable. Rectal temperature was monitored continuously and maintained at 36 degrees C.All techniques resulted in cochlear hypothermia without a concomitant change in rectal temperature. EAC irrigation (14 degrees C and 11 degrees C) decreased cochlear temperature on average by 1.1 degrees C and 1.6 degrees C, respectively. Bulla irrigation (14 degrees C and 11 degrees C) decreased cochlear temperature on average by 3.3 degrees C and 4.1 degrees C, respectively. The ice produced an average cochlear temperature decrease of 4.1 degrees C. In all cases, a cochlear temperature nadir was reached in 5-6 min with no significant differences between groups with respect to time.

Published
2007
Full Text
View/download PDF

48. Electrode array-eluted dexamethasone protects against electrode insertion trauma induced hearing and hair cell losses, damage to neural elements, increases in impedance and fibrosis: A dose response study

Author

Carolyn Garnham, Jorge Bohorquez, Enrique Perez, Christine T. Dinh, Thomas R. Van De Water, Adrien A. Eshraghi, Roland Hessler, Stefania Goncalves, and Esperanza Bas

Subjects
Male, medicine.medical_specialty, Hearing loss, Guinea Pigs, Silicones, Audiology, Reference electrode, Dexamethasone, Masson's trichrome stain, 03 medical and health sciences, 0302 clinical medicine, Hearing, Hair Cells, Auditory, otorhinolaryngologic diseases, Electrode array, medicine, Animals, 030223 otorhinolaryngology, Electrodes, Cochlea, Neurons, Dose-Response Relationship, Drug, Chemistry, Scala Tympani, Cochlear Implantation, Fibrosis, Sensory Systems, medicine.anatomical_structure, Organ of Corti, Electrode, Female, sense organs, Hair cell, Stress, Mechanical, medicine.symptom, 030217 neurology & neurosurgery, Biomedical engineering
Abstract

We evaluated the effects of dexamethasone base (DXMb) containing electrode arrays in a guinea pig model of cochlear implantation to determine if eluted DXMb could protect the cochlea against electrode insertion trauma (EIT)-induced: 1) loss of hair cells; 2) disruption of neural elements; 3) increases in hearing thresholds; 4) increased electrical impedance and 5) fibrosis. A guinea pig model of EIT-induced hearing and hair cell losses was used to test silicone electrode arrays that contained either 10%, 1%, 0.1%, or 0% levels of micronized DXMb. These four types of electrode arrays were implanted into the scala tympani via basal turn cochleostomies and left in place for 3 months. Hearing thresholds were determined by ABR and CAP recordings in response to a series of defined pure tone stimuli (i.e. 16-0.5 kHz). Changes in impedance were measured between the implant electrode and a reference electrode. Hair cell counts and neural element integrity were determined by confocal microscopy analyses of stained organ of Corti whole mounts obtained from 90 day post-implantation animals. Fibrosis was measured in Masson trichrome stained cross-sections through the organ of Corti. The results showed that either 10% or 1.0% DXMb eluting electrode arrays protected; hearing thresholds, hair cells, and neural elements against EIT-induced losses and damage. Electrode arrays with 0.1% DXMb only partial protected against EIT-induced hearing loss and damage to the cochlea. Protection of hearing thresholds and organ of Corti sensory elements by electrode-eluted DXMb was still apparent at 3 months post-EIT. All three concentrations of DXMb in the electrode arrays prevented EIT-induced increases in impedance. EIT-initiated fibrosis was significantly reduced within the implanted cochlea of the two DXMb concentrations tested. In conclusion, DXMb eluting electrodes protected the cochlea against long term increases in hearing thresholds, loss of hair cells, damage to neural elements and increases in impedance and fibrosis that result from EIT-initiated damage. The protection achieved by DXMb-eluting electrodes was dose dependent. Establishing a significant level of trauma induced elevation in hearing thresholds was important for the determination of the otoprotective effects of array-eluted DXMb.

Published
2015

49. Spiral Ganglion Cells and Macrophages Initiate Neuro-inflammation and Scarring Following Cochlear Implantation

Author

Thomas R. Van De Water, Stefania Goncalves, Christine T. Dinh, Esperanza Bas, Adrien A. Eshraghi, Jose Manuel Bas, and Michelle Adams

Subjects
Pathology, medicine.medical_specialty, medicine.medical_treatment, Inflammation, lcsh:RC321-571, Extracellular matrix, Cellular and Molecular Neuroscience, neuro-inflammation, Fibrosis, Cochlear implant, otorhinolaryngologic diseases, Medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Spiral ganglion, Cochlea, Original Research, business.industry, Regeneration (biology), Macrophages, cochlear implant, spiral ganglion neurons, medicine.disease, medicine.anatomical_structure, sense organs, Schwann Cells, medicine.symptom, Wound healing, business, Neuroscience
Abstract

Conservation of a patient’s residual hearing and prevention of fibrous tissue/new bone formation around an electrode array are some of the major challenges in cochlear implant (CI) surgery. Although it is well known that fibrotic tissue formation around the electrode array can interfere with hearing performance in implanted patients, and that associated intracochlear inflammation can initiate loss of residual hearing, little is known about the molecular and cellular mechanisms that promote this response in the cochlea. In vitro studies in neonatal rats and in vivo studies in adult mice were performed to gain insight into the pro-inflammatory, proliferative, and remodeling phases of pathological wound healing that occur in the cochlea following an electrode analogue insertion. Resident Schwann cells, macrophages/microglia, and fibroblasts had a prominent role in the inflammatory process in the cochlea. Leukocytes were recruited to the cochlea following insertion of a nylon filament in adult mice, where contributed to the inflammatory response. The reparative stages in wound healing are characterized by persistent neuro-inflammation of spiral ganglion neurons and expression of regenerative macrophages in the cochlea. Accordingly, genes involved in extracellular matrix deposition and remodeling were up-regulated in implanted cochleae.Maturation of scar tissue occurs in the remodeling phase of wound healing in the cochlea. Similar to other damaged peripheral nerves, M2 macrophages and de-differentiated Schwann cells were observed in damaged cochleae and may play a role in cell survival and axonal regeneration. In conclusion, the insertion of an electrode analogue into the cochlea is associated with robust early and chronic inflammatory responses characterized by recruitment of leukocytes and expression of pro-inflammatory cytokines that promote intracochlear fibrosis and loss of auditory hair cells and spiral ganglion neurons important for hearing after CI surgery.

Published
2015
Full Text
View/download PDF

50. Inhibition of the c-Jun N-Terminal Kinase-Mediated Mitochondrial Cell Death Pathway Restores Auditory Function in Sound-Exposed Animals

Author

Christophe Bonny, Jing Wang, Sabine Ladrech, Thomas R. Van De Water, Jean-Luc Puel, Jérôme Ruel, Hamel, Christian, Physiopathologie et thérapie des déficits sensoriels et moteurs, Université Montpellier 2 - Sciences et Techniques (UM2)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoires Auris SAS, Division de Génétique Médicale, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Department of Otolaryngology, and University of Miami [Coral Gables]

Subjects
Proto-Oncogene Proteins c-jun, Apoptosis, Sound exposure, MESH: Animals, Phosphorylation, bcl-2-Associated X Protein, MESH: Peptides, Microfilament Proteins, c-jun, Cytochromes c, MESH: Cytochromes c, Anatomy, Mitochondria, Cell biology, Protein Transport, medicine.anatomical_structure, Caspases, Molecular Medicine, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Hair cell, Signal transduction, Programmed cell death, MAP Kinase Signaling System, MESH: Mitochondria, MESH: Phosphorylat, Guinea Pigs, MESH: Carrier Proteins, Biology, MESH: Hair Cells, MESH: Guinea Pigs, Necrosis, MESH: Microfilament Proteins, Hair Cells, Auditory, otorhinolaryngologic diseases, medicine, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Protein kinase A, Cochlea, MESH: Necrosis, Pharmacology, MESH: Caspases, MESH: MAP Kinase Signaling System, MESH: Apoptosis, JNK Mitogen-Activated Protein Kinases, MESH: Hearing Loss, Noise-Induced, MESH: JNK Mitogen-Activated Protein Kinases, Hearing Loss, Noise-Induced, Round Window, Ear, Carrier Proteins, Peptides
Abstract

We tested and characterized the therapeutic value of round window membrane-delivered (RWM) d-JNKI-1 peptide (Bonny et al., 2001) against sound trauma-induced hearing loss. Morphological characteristics of sound-damaged hair cell nuclei labeled by Hoechst staining show that apoptosis is the predominant mode of cell death after sound trauma. Analysis of the events occurring after sound trauma demonstrates that c-Jun N-terminal kinase (JNK)/stress-activated protein kinase activates a mitochondrial cell death pathway (i.e., activation of Bax, release of cytochrome c, activation of procaspases, and cleavage of fodrin). Fluorescein isothiocyanate (FITC)-conjugated d-JNKI-1 peptide applied onto an intact cochlear RWM diffuses through this membrane and penetrates cochlear tissues with the exception of the stria vascularis. A time sequence of fluorescence measurements demonstrates that FITC-labeled d-JNKI-1 remains in cochlear tissues for as long as 3 weeks. In addition to blocking JNK-mediated activation of a mitochondrial cell death pathway, RWM-delivered d-JNKI-1 prevents hair cell death and development of a permanent shift in hearing threshold that is caused by sound trauma in a dose-dependent manner (EC50 = 2.05 microM). The therapeutic window for protection of the cochlea from sound trauma with RWM delivery of d-JNKI-1 extended out to 12 h after sound exposure. These results show that the mitogen-activated protein kinase/JNK signaling pathway plays a crucial role in sound trauma-initiated hair cell death. Blocking this signaling pathway with RWM delivery of d-JNKI-1 may have significant therapeutic value as a therapeutic intervention to protect the human cochlea from the effects of sound trauma.

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results