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In this paper, we present a multi-sensor approach employed to obtain the 3D model of the Roman temple of Bziza (Lebanon) and its surroundings, a work carried out as part of the archaeological Northern Lebanon Project (NoLeP). The integration of photogrammetry and portable mobile mapping technology was tested to overcome the weaknesses of each individual surveying method, with the aim of producing a complete and realistic 3D reconstruction of the whole site, as well as capturing at high-resolution the architectural features of the main structure. Moreover, this case study serves to further investigate the accuracy that can be reached with mobile laser scanners, highlighting benefits and limitations of this rapid and efficient mapping technique also in the field of Cultural Heritage documentation.

Introduction Persons with temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS) have a high frequency of psychiatric disorders, namely depression and anxiety. In addition, poor quality of life (QOL) and impairments in psychosocial adjustment are frequently reported. Despite the increasing number of studies aiming to identify predictors of poorer QOL, the role of depressive and anxiety symptoms remains poorly understood. Objectives This study aimed to evaluate: (1) if psychosocial adjustment predicts worse QOL; (2) the relationship between psychosocial adjustment and QOL by concurrently examining the role of depressive and anxiety symptoms. Methods: Participants Thirty-five persons with TLE-HS ranging from 18 to 60 years old (mean age 39.82 SD 9.05; 20 men 57.14%) followed in a tertiary outpatient center underwent neurologic and psychiatric assessments. Assessments The psychiatry interview was performed using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (SCID). Psychosocial adjustment was assessed with the total score of the Social Adjustment Scale (SAS) (SAS Overall). The QOL was evaluated by the total score of the Quality of Life in Epilepsy-31 Inventory (Overall QOLIE-31), the most frequently used instrument in assessing QOL in epilepsy. The Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI-X) were used to assess depressive and anxiety symptoms, respectively. Analyses Prediction analysis was performed to evaluate the impact of psychosocial adjustment on QOL (simple linear regression). Simple moderation models were used to examine the moderation effect of depressive and anxiety symptoms on the association between PA and QOL (Figure 1). We used SPSS (version 29 IBM Corp) and PROCESS Macro (version 4.1. for SPSS) to perform regression and moderation analyses (Figures 2 and 3), respectively. Results Poor psychosocial adjustment (higher scores on SAS) impacted on poor QOL (lower scores on QOLIE-31) (R=0.39; R2=0.15; adjusted R2= 0.12; B=-0.39; t=-2.28; p=0.03). The severity of anxiety symptoms (Trait and State; coefficient=-0.64; t=-2.01; p=0.05 and coefficient=-1.17; t=-2.20; p=0.03, respectively), but not the severity of depressive symptoms (coefficient=0.77; t= 1.37; p=0.18), moderated the relationship between psychosocial adjustment and QOL. Image: Image 2: Image 3: Conclusions Psychosocial adjustment is a predictor of QOL in TLE-HS. Anxiety symptoms moderate this relationship between psychosocial adjustment and QOL. Consequently, higher anxiety symptoms are associated with worse psychosocial adjustment and quality of life. Disclosure of Interest None Declared

The systematic study of misanthropy, the lack of trust in humanity, has proliferated over the last 30 years. One prominent line of research details racial and ethnic disparities in levels of misanthropy, but pays little attention to the role of religiosity, while another focuses attention on religiosity and its impact on levels of misanthropy, with only scant attention to the role of race and ethnicity. Little attempt has been made to synthesize these two strands of literature to address an important unanswered question: Does the association between religiosity and misanthropy vary by racial and ethnic group? To answer this question, we pooled data from the General Social Survey (GSS, 2000–2018). Among other things, we find stark racial differences between Blacks and Whites in terms of the effect of religiosity on misanthropy. Blacks and Latinos who attend religious services weekly (social religiosity) have significantly higher levels of misanthropy than others, while Whites who attend weekly services are less likely to be misanthropic. An important takeaway is that service attendance (a type of social capital) is associated with feelings of misanthropy for all groups (albeit in opposite directions for Blacks and Latinos versus Whites), rather than personal acts of prayer (individual religiosity). When it comes to misanthropy, we conclude that religion works differently for minorities compared with Whites. We discuss the implications of our findings for future research.

While plastics have revolutionized our world, plastic waste has serious environmental and economic impacts. Polyhydroxyalkanoic acid (PHA) is a bacterial carbon and energy reserve shown to be both biodegradable and biocompatible and could potentially replace conventional plastics. However, cost-effective mass production remains elusive. Bacteria often accumulate PHA as cytoplasmic granules. PHA synthase creates the PHA polymer from acetoacyl-CoA monomers, while phasins are small multifunctional proteins that are found in abundance on the granule surface. The PHA synthase gene from a novel marine isolate, Vibrio B-18 (or B-18), was placed in the presence or absence of an upstream phasin gene in a runaway replication plasmid using polymerase chain reaction (PCR) technology. Plasmid gene expression may be induced chemically or thermally. Overexpression of the PHA genes was demonstrated by SDS-PAGE analysis, and microscopy was used to detect PHA accumulation in three different enteric bacteria (Escherichia coli, Klebsiella aerogenes, and Shigella flexneri). While the B-18 genes were clearly overexpressed at 41°C, PHA accumulation occurred more readily at the lower (30°C) non-inducing temperature regardless of chemical induction if the phasin gene was present. A mutational analysis confirmed the identity of the start codon for the PHA synthase gene and provided evidence supporting the requirement for phasins to allow for PHA accumulation in the recombinant hosts. The findings described in this study confirm the conclusions obtained from related studies from other laboratories and lend support to the importance of including a phasin gene in addition to the basic genes needed for PHA synthesis and accumulation in recombinant enteric bacteria, such as Escherichia coli, Klebsiella aerogenes, and Shigella flexneri.

This paper presents the survey of the Baptistery of the Collegiata Museum (Castiglione Olona - Italy), painted by Masolino da Panicale in 1435. Surveying activity was carries out throughout the use of combined digital techniques of documentation (topographic measurements, laser scanning, digital photogrammetry, thermal imaging, digital photography). Different data were collected inside and outside the Baptistery following a multi-resolution reconstruction that ranges from the whole Baptistery up to small details. Laser scans were also used to obtain a digital representation of inner volumes of the structure. Registered scans were uploaded into a modelling software, in order to produce a 3D model based on scan data, increasing the correspondence with the existent building; this model can be used to better understand the volume arrangement, also for educational and dissemination purposes. A particular attention was devoted to documentation of graffiti scratched onto the frescos, since their presence is a significative evidence of the history of the building. A digital-based workflow was set out in order to assure high quality outputs in respect of the conservation needs.This multi-resolution approach proved to be a suitable solution when dealing with features, such as ancient architectures, with a high number of complex details to be correctly recorded and joint together as starting point and support of historical researches. Results and scope are here presented.

Metric documentation of buildings requires the connection of different spaces, such as rooms, corridors, floors, and interior and exterior spaces. Images and laser scans have to be oriented and registered to obtain accurate metric data about different areas and the related metric information (e.g., wall thickness). A robust registration can be obtained with total station measurements, especially when a geodetic network with multiple intersections on different station points is available. In the case of a photogrammetric project with several images acquired with a central perspective camera, the lack of total station measurements (i.e., control and check points) could result in a weak orientation for the limited overlap between images acquired through doors and windows. The procedure presented in this paper is based on 360° images acquired with an affordable digital camera (less than 350$). The large field of view of 360° images allows one to simultaneously capture different rooms as well as indoor and outdoor spaces, which will be visible in just a picture. This could provide a more robust orientation of multiple images acquired through narrow spaces. A combined bundle block adjustment that integrates central perspective and spherical images is here proposed and discussed. Additional considerations on the integration of fisheye images are discussed as well.

Ancient graffiti are a valuable and constant historical evidence through the human history, regardless from the geographic area or historical period. They can be found on different kinds of surfaces and in different contexts, such as religious building or civic structures, in public or private environments. Their study and comprehension need to be grounded on good and complete documentation techniques. The application of accurate recording methods is even more important for ancient graffiti, for a series of reasons. First of all, their perception is often less immediate than other historical or artistic evidence, and directly depends on external aspects, such as the lighting conditions, and personal skills. Moreover, their interpretation is often challenging also for expert scholars, so as to require both the most objective reproduction possible and the personal interpretation of the scholar. As a case study, several late medieval graffiti scratched on frescos have been documented with digital methods. Results will be presented and discussed. This paper will mainly focus on graffiti scratched on frescos or plaster, and not on petroglyphs, i.e. marks and drawings on rock surfaces.

There is a dearth of research on Holocaust survivors who immigrated to Brazil before, during, and after World War II. Also missing is a comprehensive analysis of how former Nazis escaped to the country after the War. This “co-existence” of Jewish survivors and Nazis within the same geographical location at the same time is a topic of great complexity, which I explore in this paper. In the first section of this paper, I will briefly address Brazil’s political history, while at the same time, its identity as an immigrant country, with a historically multi-ethnic cultural and demographic make-up, by analyzing the census data available. To explore how Jews negotiated their new position as survivors, immigrants, and members of a minority group who, while lived with the possibility of coexisting with war criminals, in section two, I analyze the memoirs of Aleksander Laks and Sabina Kustin, who, in different ways, transferred their fears from the old world to their new realities, due to imagined or real Nazi presence, which afflicted their existence and identity as Jews in Brazil. In the last section, I address the question of Nazi presence in Brazil. Using newspaper articles and governmental documentation, I highlight strategies used by war criminals such as Herbert Cukurs and Gustav Franz Wagner, to live freely in Brazil, and evade justice.

Documentation on archaeological fieldworks needs to be accurate and time-effective. Many features unveiled during excavations can be recorded just once, since the archaeological workflow physically removes most of the stratigraphic elements. Some of them have peculiar characteristics which make them hardly recognizable as objects and prevent a full 3D documentation. The paper presents a suitable feature-based method to carry on archaeological documentation with a three-dimensional approach, tested on the archaeological site of S. Calocero in Albenga (Italy). The method is based on one hand on the use of structure from motion techniques for on-site recording and 3D Modelling to represent the three-dimensional complexity of stratigraphy. The entire documentation workflow is carried out through digital tools, assuring better accuracy and interoperability. Outputs can be used in GIS to perform spatial analysis; moreover, a more effective dissemination of fieldworks results can be assured with the spreading of datasets and other information through web-services.

This essay describes the combination of 3D solutions and software techniques with traditional studies and researches in order to achieve an integrated digital documentation between performed surveys, collected data, and historical research. The approach of this study is based on the comparison of survey data with historical research, and interpretations deduced from a data cross-check between the two mentioned sources. The case study is the Basilica of S. Ambrogio in Milan, one of the greatest monuments in the city, a pillar of the Christianity and of the History of Architecture. It is characterized by a complex stratification of phases of restoration and transformation. Rediscovering the great richness of the traditional architectural notebook, which collected surveys and data, this research aims to realize a virtual notebook, based on a 3D model that supports the dissemination of the collected information. It can potentially be understandable and accessible by anyone through the development of a mobile app. The 3D model was used to explore the different historical phases, starting from the recent layers to the oldest ones, through a virtual subtraction process, following the methods of Archaeology of Architecture. Its components can be imported into parametric software and recognized both in their morphological and typological aspects. It is based on the concept of LoD and ReverseLoD in order to fit the accuracy required by each step of the research.

Today, the field of cultural heritage faces many challenges: cultural heritage is always at risk, the large amount of heritage information is often fragmented, climate change impacts cultural heritage and heritage recording can be time-consuming and often results in low accuracy. Four objectives, related to the challenges, were defined during this research work. It proposes a relevant value-led risk management method for cultural heritage, it identifies climate change impact on cultural heritage, it suggests a database lay-out for cultural heritage and demonstrates the potential of remote sensing tools for cultural heritage. The Via Iulia Augusta, a former Roman road in Albenga, was used as case study.

Following the implementation of the Lei das Cotas (Affirmative Action Law) in Brazil, there has been debate as to whether students who were admitted through affirmative action perform at the same level as students admitted through traditional methods. This article examines the results of the Exame Nacional de Desempenho dos Estudantes (ENADE) from 2009 to 2012 to determine whether there is a relationship between students’ performance at the university level and the manner of their admittance. We find that students admitted to public universities under affirmative action perform at similar levels to students who were not, whereas quota students in private universities perform slightly better than students admitted through traditional methods.Com a implementação das Lei das Cotas no Brasil, tem se debatido se estudantes admitidos através de ação afirmativa demonstram o mesmo nível acadêmico dos estudantes admitidos através de métodos tradicionais. Este artigo analisa os resultados do Exame Nacional de Desempenho dos Estudantes (ENADE) durante o período de 2009 á 2012 para determinar se existe uma relação entre o desempenho dos alunos no âmbito universitário e as modalidades da sua admissão. Nossa análise revela que os estudantes que foram admitidos em universidades públicas através de ações afirmativas têm o mesmo desempenho acadêmico de estudantes que não se beneficiam de ações afirmativas, enquanto alunos cotistas em universidades privadas têm um desempenho ligeiramente melhor do que alunos admitidos através de métodos tradicionais.

Fires are an important factor in shaping Earth's ecosystems. Plant and animal life, in almost every land habitat, are at least partially dependent on the effects of fire. However, their destructive force, which has often proven uncontrollable, is one of our greatest concerns, effectively resulting in several policies in the most important industrialised regions of the globe. This paper aims to comprehensively characterise the Forest Fire Finder (FFF), a forest fire detection system based mainly upon a spectroscopic technique called differential optical absorption spectroscopy (DOAS). The system is designed and configured with the goal of detecting higher-than-the-horizon smoke columns by measuring and comparing scattered sunlight spectra. The article covers hardware and software, as well as their interactions and specific algorithms for day mode operation. An analysis of data retrieved from several installations deployed in the course of the last 5 years is also presented. Finally, this paper features a discussion on the most prominent future improvements planned for the system, as well as its ramifications and adaptations, such as a thermal imaging system for short-range fire seeking or environmental quality control.

This essay describes an integrated approach – field survey, historic research, climate data, and topography – for the analysis of a complex stratigraphical archaeological site, highlighting its peculiar aspects and its conservation state, and contributing to the studies of this area. The case study is San Calocero monastery in Albenga, one of the most important historical evidence of the city, located on the San Martino Hillside, dating back to the VI century but with a complex historical stratigraphy until the XVI century, along with other relevant archaeological sites, such as the Baptistery, the Ponte Lungo, the churches of San Clemente and San Vittore, which, as long as San Calocero, went through several changes over the years.

This paper analyzes the consequences of peer victimization for the satisfaction with schooling (“happiness”) of college-bound high school graduates in Brazil. Several types of victimization are explored including discrimination due to race/ethnicity, socioeconomic status, gender, sexual orientation, religious affiliation, and disability. We compare the satisfaction with their schooling of students planning to head to college straight from high school and older students applying for college later in life (“nontraditional students”). We conclude that students who perceived that they had been discriminated against were more dissatisfied with their school experience than those who did not, ceteris paribus, and we relate level of dissatisfaction to type of discrimination. The older student evidence reveals that this dissatisfaction wanes with time and age, however. Our conclusions are based upon ordered logistic analyses of data for 2.4 million current high school seniors and 78.7 thousand older students drawn from the Exame Nacional do Ensino Médio questionnaire (ENEM).

Although antibiotic-induced dysbiosis has been demonstrated to exacerbate intestinal inflammation, it has been suggested that antibiotic prophylaxis may be beneficial in certain clinical conditions such as acute pancreatitis (AP). However, whether broad-spectrum antibiotics, such as meropenem, influence the dissemination of multidrug-resistant (MDR) bacteria during severe AP has not been addressed. In the currently study, a mouse model of obstructive severe AP was employed to investigate the effects of pretreatment with meropenem on bacteria spreading and disease outcome. As expected, animals subjected to biliopancreatic duct obstruction developed severe AP. Surprisingly, pretreatment with meropenem accelerated the mortality of AP mice (survival median of 2 days) when compared to saline-pretreated AP mice (survival median of 7 days). Early mortality was associated with the translocation of MDR strains, mainly Enterococcus gallinarum into the blood stream. Induction of AP in mice with guts that were enriched with E. gallinarum recapitulated the increased mortality rate observed in the meropenem-pretreated AP mice. Furthermore, naïve mice challenged with a mouse or a clinical strain of E. gallinarum succumbed to infection through a mechanism involving toll-like receptor-2. These results confirm that broad-spectrum antibiotics may lead to indirect detrimental effects during inflammatory disease and reveal an intestinal pathobiont that is associated with the meropenem pretreatment during obstructive AP in mice.

The aim of this work is to study the value and potential of UAV technology as an instrument for documenting and analyzing a heritage site on both the detailed scale and the wider territorial scale. In particular, this paper will focus on the application of an UAV platform on the archeological site of Isola Comacina (Comacina Island), in the Lago di Como (Lake Como, Lombardy, Northern Italy). The work considers the advantages of different metric scales and the use of both RGB and thermal imagery, along with other terrestrial data (total station measurements and laser scans), in order to arrive at a working heritage information model. In particular, the archaeological remains on Isola Comacina have been intensively studied before by standard techniques but unfortunately no wider context is provided. A part of the research is the investigation of new methodologies offered by accurate geometric reconstructions combined with thermal imagery acquired by means of UAV platforms, e.g. the support of this type of imagery to discover rock formations partially buried.

The relationship between depression and epilepsy has been known since ancient times, however, to date, it is not fully understood. The prevalence of psychiatric disorders in persons with epilepsy is high compared to general population. It is assumed that the rate of depression ranges from 20 to 55% in patients with refractory epilepsy, especially considering those with temporal lobe epilepsy caused by mesial temporal sclerosis. Temporal lobe epilepsy is a good biological model to understand the common structural basis between depression and epilepsy. Interestingly, mesial temporal lobe epilepsy and depression share a similar neurocircuitry involving: temporal lobes with hippocampus, amygdala and entorhinal and neocortical cortex; the frontal lobes with cingulate gyrus; subcortical structures, such as basal ganglia and thalamus; and the connecting pathways. We provide clinical and brain structural evidences that depression and epilepsy represent an epiphenomenon sharing similar neural networks.

The relationship between depression and epilepsy has been known since ancient times, however, to date, it is not fully understood. The prevalence of psychiatric disorders in persons with epilepsy is high compared to general population. It is assumed that the rate of depression ranges from 20 to 55% in patients with refractory epilepsy, especially considering those with temporal lobe epilepsy caused by mesial temporal sclerosis. Temporal lobe epilepsy is a good biological model to understand the common structural basis between depression and epilepsy. Interestingly, mesial temporal lobe epilepsy and depression share a similar neurocircuitry involving: temporal lobes with hippocampus, amygdala and entorhinal and neocortical cortex; the frontal lobes with cingulate gyrus; subcortical structures, such as basal ganglia and thalamus; and the connecting pathways. We provide clinical and brain structural evidences that depression and epilepsy represent an epiphenomenon sharing similar neural networks.A relação entre depressão e epilepsia é conhecida desde a antiguidade; entretanto, até o momento, não é completamente compreendida. A prevalência de transtornos psiquiátricos nas pessoas com epilepsia é elevada quando comparada à população em geral. A taxa de depressão varia de 20 a 55% nos pacientes com epilepsia refratária, especialmente considerando-se aqueles com epilepsia do lobo temporal causada por esclerose mesial temporal. A epilepsia do lobo temporal é um bom modelo biológico para compreender as bases estruturais comuns entre a epilepsia e a depressão. É relevante ressaltar que a epilepsia do lobo mesial e a depressão apresentam circuitos similares envolvendo: os lobos temporais com o hipocampo, a amigdala, o córtex entorrinal e o neocortex; os lobos frontais com o giro cíngulo; estruturas subcorticais, como os núcleos da base e o tálamo, e suas vias de conexão. Postulamos por meio de evidências clínicas e estruturais que a depressão e a epilepsia representam um epifenômeno com redes neuronais similares.

A simple, precise, specific, repeatable and discriminating dissolution test for primaquine (PQ) matrix tablets was developed and validated according to ICH and FDA guidelines. Two UV assaying methods were validated for determination of PQ released in 0.1 M hydrochloric acid and water media. Both methods were linear (R²>0.999), precise (R.S.D.

OBJETIVO: Avaliar a sobrevida fetal usando uma nova técnica cirúrgica para criação de um defeito semelhante a meningomielocele em fetos de coelho. MÉTODOS: Foram utilizadas seis coelhas da linhagem Nova Zelândia que tiveram um defeito espinhal criado em seus fetos no 23° dia de gestação. O defeito foi criado em 19 fetos e a tentativa de correção foi feita em 15 casos (grupo I), 4 fetos permaneceram sem correção (grupo II). No 30° dia de gestação, os fetos foram submetidos a avaliação anátomo-patológica. RESULTADOS: No 30° dia a meningomielocele estava presente em todos os fetos sobreviventes. A sobrevida total foi de 73,68% (14/19), 11 fetos sobreviveram no grupo I, e 3 no grupo II. CONCLUSÃO: A técnica modificada apresenta sobrevida fetal satisfatória, no modelo experimental de criação de defeito espinhal em fetos.PURPOSE: To evaluate fetal survival rate using a modified technique to surgically create a "myelomeningocele-like" defect in the rabbit model. METHODS: Six white New Zealand rabbits had a spinal defect created in their fetuses at 23 days of gestation. The defect was created in 19 fetuses and an attempt to correct it was made in 15 cases (group I), 4 fetuses where left without correction (group II)At 30 days of gestation, fetuses were harvested for anathomo-pathologic evaluation. RESULTS: At 30 days, a "myelomeningocele-like" defect was present in all surviving fetuses. The total survival rate was 73,68% (14/19), 11 fetus survived in group I and 3 in group II. CONCLUSION: The technique modifications including fetal positioning and exposure of its back prior to the incision of the lamina associated to a different technique for miometrium closure offers an alternative and probably safer method to surgically create a spinal defect in the fetal rabbit.