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In higher education institutions, many faculty members are hired because they are experts in their field of study, but not necessarily individuals who are trained in how to teach. This quantitative quasi-experimental study examined college faculty member's level of methodology training in relation to student satisfaction, current course performance, attendance, the belief in the need for training, and a faculty member's sense of efficacy in teaching. In other words, does having a college professor trained in how to teach matter? The researcher found statistically significant results for student satisfaction, current course performance, and attendance. The faculty member's belief in the need for teaching methodology training showed that 96% (n = 87) of the faculty surveyed felt there was a need to be trained to teach at the college level. Faculty members want to be trained and great things can happen when faculty members develop the skills in "how to teach."

This study investigated what features undergraduate EFL learners perceive as affecting the difficulty of model paragraphs. Four hundred and seventy-five Vietnamese undergraduates participated in a partial least squares structural equation model design. They ranked five paragraphs from easiest to most difficult and responded to a 10-point Likert questionnaire regarding 11 features (titles, paragraph length, vocabulary, vocabulary in context, rhetorical organization, paragraph structure, sentence length, punctuation, signal words, interest, background knowledge). The results showed that eight variables (titles, vocabulary, vocabulary in context, sentence length, rhetorical organization, paragraph structure, interest, background knowledge) had a significant direct effect and four variables (vocabulary, sentence length, rhetorical organization, background knowledge) had mediating effects. The model accounted for 0.508 R[superscript 2] of students' perceptions, with a moderate to high predictive relevance (Q[superscript 2] = 0.35). The paper also discusses the results' implications for those in writing studies and the publishing industry. Suggestions for future study are also presented.

In occupational therapy practice, critical thinking is a foundational skill for the delivery of effective care; however, there is limited evidence on the development of critical thinking skills in occupational therapy education. The purpose of this study was to explore the effects and student perceptions of concept mapping on critical thinking skills in occupational therapy education. This study used a quasiexperimental design with a retrospective pre-post assessment after two teaching conditions: (a) traditional lecture and (b) concept mapping. The same convenience sample of students was used for each condition. Additional outcome measures included assessment of student concept maps using a scoring rubric and a survey of students' perceptions on the use of concept mapping. Results of the retrospective pre-post assessment indicated significant gains in student knowledge (p<0.001) following both the concept mapping activity (n=39) and traditional lecture (n=46). Assessment of the concept maps along with the results of the student survey indicated that concept mapping supported student use of key critical thinking skills including interpreting knowledge, understanding relationships, communicating their rationale, and reflecting on their thinking. Overall, students reported strong affective acceptance of concept mapping and found concept mapping easy to use. Given these findings, occupational therapy educators need to consider incorporating concept mapping as a form of active, student-centered learning to support enhanced knowledge of content and higher-level thinking.

Extensive reading (ER) provides young English language learners (YELLs) many benefits, including the sustainable development of writing (e.g., the reading-writing relationship). However, this area is underresearched. To address this, this quasi-experimental study investigated the effect of ER on YELLs' second language writing achievement using an enhanced ER treatment. Pre- and post-Cambridge Primary English Test (PET) samples were collected and evaluated via the PET analytic rubric total band and subscales scores (Content, Communicative Achievement, Organization, Language). The results indicated that the EG outperformed the CG in total band score and three subscale bands (Content, Organization, Language), and the EG and CG performed comparably well in the fourth (Communicative Achievement). As prior research specific to ER's effect on YELLs' writing achievement in the Vietnam context is noticeably understudied, this study offers a starting point for future investigations.

Research highlights the many benefits of study abroad in higher education with emerging scholarship on study abroad in K-12 education. This paper focuses on how leading study abroad fosters a collaborative, cosmopolitan-oriented, professional environment for secondary teachers in Washington, D.C. Public Schools (DCPS). Theoretically we apply frameworks related to the development of cosmopolitan capital and the formation of collaborative professional communities. Using a qualitative case study approach, we draw on data from interviews, written materials, observations of pre-departure meetings and training, and post-program survey responses. Analysis illustrates several emergent themes: First, educators with previous international experience tend to seek out globally oriented in-service teacher education experience. Second, the majority of participating teachers report leading study abroad experience as beneficial to them. Third, findings show the importance of forming professional communities among global educators. Together these findings signal the unique benefits of study abroad in teacher education and professional development settings.

Early childhood aggression is a ubiquitous and developmentally normal behavior; however, different report sources (e.g., child self-report vs. teacher) often yield markedly different interpretations. The current study examined how typical demographic and cognitive factors that have been previously found to explain child behavior (e.g., SES, inhibitory control) differentially explain child aggression and prosociality as a function of the informant. Preschool-age children (N = 121) completed several cognitive tasks (PPVT, Theory of Mind battery, Day/Night Stroop, moral judgment) as well as a dual-puppet self-report behavior interview. Parents reported demographics. Teachers completed the Preschool Proactive and Reactive Aggression-Teacher Report. As expected, teachers' and children's reports differed considerably and corresponded with different aspects of child development--teachers' reports of aggression were largely explained by demographic variables (i.e., fathers' education level), whereas children's self-reports of aggression were explained by cognitive maturation (i.e., PPVT and moral understanding). These findings support the continued position that studies of early childhood psychopathology should employ multiple mixed methods of reporting, and considers the strengths and weaknesses of each approach.

The idea that reading model essays facilitates better writing is generally accepted in second language writing literature. As such, anthologies of model essays are often selected for inclusion in writing centre self-access library shelves. When selecting these texts, readability is often considered via the application of quantitative readability formulae (e.g. the Lexile Readability Formula). Unfortunately, such formulae only measure two (i.e. semantic, syntactic) of the many features that impact readability, leaving other features that require qualitative consideration (e.g. signal words, SWs) unexplored. To address this, this article reports the findings of a sequential, mixed-methods study conducted in a Taiwanese university writing centre context that explored how SWs affect post-secondary English language learners' perceptions of ease and difficulty when reading model essays excerpted from anthologies. The inferential statistics showed that the informants (students who visited the writing centre) ranked the essays' ease and difficulty significantly differently than the Lexile Formula. The qualitative exploration found that SWs (e.g. students' awareness of SWs) contributed to this ranking. The study also suggests that writing studies professionals (teachers, writing centre staff) and the publishing industry include signal words as part of a hybrid (quantitative-qualitative) exploration when considering the difficulty of model essays in anthologies.

Parental support or resistance has been widely recognised as an important factor that enables or constrains the implementation of quality Relationships and Sexuality Education (RSE). This paper analyses parental experiences of involvement and engagement with Gender Equality Matters (GEM), an educational programme focused on raising awareness, building confidence and enhancing capacity levels among children to tackle gender inequality and promote LGBTQI inclusion. The paper focuses on qualitative data from participating parents in the Irish primary school context. Pre- and post-questionnaires (n = 162) and semi-structured interviews (n = 3) were utilised to gain insight into the parents' experience of participating in GEM. Using thematic analysis, the analysis explores three themes: 1) positive parental partnerships; 2) naturalistic at-home conversations; and 3) resistance and disengagement. The study highlights the key role of parental partnerships with school curricula, whilst critically reflecting on potential sites for resistance and providing a successful model for future educational programmes to adopt.

Reviewing the literature is an important part of academic work, as it helps readers see what has come before, what has and has not worked, and situates the author's place in the ongoing discussion. Accepting this view, extensive reading literature often points to Day and Bamford (1988) as identifying Kelly (1969) as crediting Palmer (1921) as the first to apply the term extensive reading (ER) in L2 pedagogy. At the time of Day and Bamford and Kelly's publications, a reference to Palmer was a worthy seminal identification as literature searches were not aided by today's more powerful electronic databases. Utilizing more modern search tools (Archive.org, Google Books, JSTOR, Project Gutenberg, Google Books) and the archival works they provide, we extend the discussion by offering a more complete history of the term for researchers to draw from. Specifically, we (a) explore early L1 uses of the term and (b) point to three new L2 seminal benchmarks: the earliest (1) use of the term (2) intensive/extensive distinction; and (3) definition found to date. We then (c) continue our discussion up through today's modern definitions of the term. Directions for future studies are also discussed.

Background: Research has demonstrated that the loss of one or more natural teeth can be an emotionally traumatic experience that mirrors processes associated with bereavement. There remains scant literature examining the role of emotions in dental encounters. One such exception is the literature on the idea of the ‘treatment alliance’ in dental encounters. The aim of this paper is to explore the role of the ‘treatment alliance’ in dentist–patient encounters. Methods: Data were collected from clinical observations, semi-structured interviews and focus groups exploring the experience of tooth loss and how the treatment alliance shaped the patient journey. Data analysis was conducted using the grounded theory method influenced by phenomenology. Coding was conducted using NVIVO and the unit of analysis was the treatment alliance. Results: Twenty participants took part in the interviews (eleven male; nine female; 22–86 years; mean age = 58.9 years). Observations were carried out with a further fourteen participants (seven male; seven female; 50–101 years; mean age = 62.2 years). The paper draws on four cases taken from the observational data to illustrate important dynamics underpinning how the treatment alliance varied. These case studies are then used as the basis for a critical discussion of the importance of the treatment alliance in dentistry. Conclusions: The treatment alliance acted as an important moderator in the clinical encounter, helping to influence successful outcomes. An important foundational component of the treatment alliance was the degree of emotional work the dental team conducted when ‘getting to know’ unfamiliar patients. Whilst emotions were an important factor in dental encounters, their acknowledgement and management were not essential to all successful outcomes. Much more research is therefore needed into the role of emotional labour in dental encounters.

Objectives: To identify characteristics of beneficiaries of health care over which relative weights should be derived and to estimate relative weights to be attached to health gains according to characteristics of recipients of these gains (relativities study); and to assess the feasibility of estimating a willingness-to-pay (WTP)-based value of a quality-adjusted life-year (QALY) (valuation study). Design: Two interview-based surveys were administered – one (for the relativities study) to a nationally representative sample of the population in England and the other (for the valuation study) to a smaller convenience sample. Setting: The two surveys were administered by the National Centre for Social Research (NatCen) in respondents’ homes. Participants: 587 members of the public were interviewed for the relativities study and 409 for the valuation study. Methods: In the relativities study, in-depth qualitative work and considerations of policy relevance resulted in the identification of age and severity of illness as relevant characteristics. Scenarios reflecting these, along with additional components reflecting gains in QALYs, were presented to respondents in a series of pairwise choices using two types of question: discrete choice and matching. These questions were part of a longer questionnaire (including attitudinal and sociodemographic questions), which was administered face to face using a computer-assisted personal interview. In the valuation study, respondents were asked about their WTP to avoid/prevent different durations of headache or stomach illness and to value these states on a scale (death = 0; full health = 1) using standard gamble (SG) questions. Results: Discrete choice results showed that age and severity variables did not have a strong impact on respondents’ choices over and above the health (QALY) gains presented. In contrast, matching showed age and severity impacts to be strong: depending on method of aggregation, gains to some groups were weighted three to four times more highly than gains to others. Results from the WTP and SG questions were combined in different ways to arrive at values of a QALY. These vary from values which are in the vicinity of the current National Institute for Health and Clinical Excellence (NICE) threshold to extremely high values. Conclusions: With respect to relative weights, more research is required to explore methodological differences with respect to age and severity weighting. On valuation, there are particular issues concerning the extent to which ‘noise’ and ‘error’ in people’s responses might generate extreme and unreliable figures. Methods of aggregation and measures of central tendency were issues in both weighting and valuation procedures and require further exploration.

A micro-enzymatic method was developed to measure total cholesterol (CHOL) and triglyceride (TG) in lipoproteins and their subfractions separated by density gradient ultracentrifugation. This method had a detection limit and sensitivity below 2 mg/dl and accuracy (bias to reference sera) and imprecision (coefficient of variation) of less than 3% between 2 and 30 mg/dl for both CHOL and TG. In addition, the method was in good agreement with standardized Abell-Kendall CHOL (r = 0.98) and enzymatic TG (r = 0.99) methods. Lipoproteins from 200 microliters of plasma or serum were separated by either equilibrium (EQ)- or rate zonal (RZ)-density gradient ultracentrifugation and the resulting fractions were analyzed for CHOL and TG by the micro-enzymatic method. Lipoprotein measurements by these micro-enzymatic/density gradient methods were highly correlated with standardized Lipid Research Clinic (LRC) procedures and preparative ultracentrifugation. The EQ-density gradient procedure also allowed determination of CHOL and TG in LDL and HDL subfractions within any desired density interval. These methods will facilitate the measurements and study of lipoproteins and their subfractions especially in infants, children, the elderly, and small animals. In addition, the micro-enzymatic method may be adapted to other modes of lipoprotein separation such as liquid chromatography, electrophoresis, and precipitation. CHOL or TG determinations could be made on approximately 500 density gradient fractions per hour.

Abstract Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresistant nature of epilepsy associated with FCD may be due to a lack of well‐tolerated and precise antiepileptic drugs that can target glutamate receptors. Here, for the first time in human FCD brain slices, we show that the established, noncompetitive α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor antagonist, perampanel has potent antiepileptic action. Moreover, we demonstrate that this effect is due to a reduction in burst firing behavior in human FCD microcircuits. These data support a potential role for the treatment of refractory epilepsy associated with FCD in human patients.

Herodotus comes down to us as the father of history and his fifth-century work, the Histories, is recognized as the first in an entirely new literary genre. But mid-fifth-century historiography is missing one of the most convenient of supranational tools—a reliable dating grid, or calendar—and Herodotus simply must make do as best he can without one. Although it was first suggested by a sixth-century Scythian monk, the axis of time along the now familiar BC/AD system is of comparatively recent adoption. Partly because of bitter doctrinal disputes over when Jesus of Nazareth was born—this system is never widely accepted until a seventeenth-century Jesuit scholar suggests that Anno Domini year one is just a convenient convention and by no means an agreement. When reading Herodotus today, particularly in an annotated edition in translation providing scholarly estimates of the Julian dates for the events under discussion, it is only too easy to be blissfully unaware of the author’s extreme dating handicap

Moroishi et al. compare the occurrence of infections and associated symptoms during the first year of life with the gut microbiome at six weeks of age. Intestinal microbial diversity and the relative abundance of key taxa in early infancy may influence susceptibility to respiratory infection, wheezing, and diarrhea.

Oligonucleotides targeting mRNA are promising therapeutic agents but suffer from poor bioavailability. Here, the authors develop reduced-charge oligonucleotides with artificial LNA-amide linkages with improved cell uptake and minimal structural deviation to the DNA:RNA duplex.

Providing self-access learning opportunities in the form of brick and mortar self-access centers has long been part of universities. However, other self-access learning program options are available for contexts where limited resources may not support such structures. Accepting this, this paper describes the creation and operation of an alternative model, a satellite activity self-access program at a North-East Asian (Taiwanese) university. The paper also discusses the model’s generalizability to other contexts and offers suggestions for further study.

Hanoi and Ho Chi Minh City (HCM), the most populous cities in Vietnam, have received increasing global attention because of their poor air pollution status. As part of the recent UK-Vietnam 2-Cities project, the concentrations of trace metals in fine particulate matter have been characterized. 24-hour samples of PM2 were collected at 2 sites in Hanoi and 3 sites in HCM during two 4-week periods in September/October 2018 and March 2019. The soluble fraction of 15 trace metal(oid)s (Fe, Al, Mn, Ti, Zn, V, Cu, Ni, Co, Cd, Pb, Th, Cr, As, and Sb) bound to PM2 were analyzed by ICP-MS. The results show that Zn was the most abundant soluble metal in PM2 in both cities, with very large numbers of road vehicles (e.g. tyre wear) likely contributing in both cities and non-ferrous metal production being a substantial additional source in Hanoi. Fe and Al, derived from crustal sources, were the dominant metals after Zn. Most trace metals concentrations in Hanoi were higher than in HCM, especially toxic metals such as Pb, Cd, Cr and As. V and Ni were the only two metals having higher concentrations in HCM than in Hanoi, likely due to shipping emissions (combustion of heavy fuel oil) that strongly affect the air quality in HCM. Coal-power plants and non-ferrous metal production are likely to be the major sources of trace metals in Hanoi. Health risk assessment shows that a high carcinogenic risk exists for inhalation exposure of soluble trace metals bound to PM2 in both cities.

Chronic hypertension is a major risk factor for the development of neurodegenerative disease, yet the etiology of hypertension-driven neurodegeneration remains poorly understood. Forming a unique interface between the systemic circulation and the brain, the blood-cerebrospinal fluid barrier (BCSFB) at the choroid plexus (CP) has been proposed as a key site of vulnerability to hypertension that may initiate downstream neurodegenerative processes. However, our ability to understand BCSFB’s role in pathological processes has, to date, been restricted by a lack of non-invasive functional measurement techniques. In this work, we apply a novel Blood-Cerebrospinal Fluid Barrier Arterial Spin Labeling (BCSFB-ASL) Magnetic resonance imaging (MRI) approach with the aim of detecting possible derangement of BCSFB function in the Spontaneous Hypertensive Rat (SHR) model using a non-invasive, translational technique. SHRs displayed a 36% reduction in BCSFB-mediated labeled arterial water delivery into ventricular cerebrospinal fluid (CSF), relative to normotensive controls, indicative of down-regulated choroid plexus function. This was concomitant with additional changes in brain fluid biomarkers, namely ventriculomegaly and changes in CSF composition, as measured by T1 lengthening. However, cortical cerebral blood flow (CBF) measurements, an imaging biomarker of cerebrovascular health, revealed no measurable change between the groups. Here, we provide the first demonstration of BCSFB-ASL in the rat brain, enabling non-invasive assessment of BCSFB function in healthy and hypertensive rats. Our data highlights the potential for BCSFB-ASL to serve as a sensitive early biomarker for hypertension-driven neurodegeneration, in addition to investigating the mechanisms relating hypertension to neurodegenerative outcomes.

Abstract Background Targeted contrast nanoparticles for breast tumor imaging facilitates early detection and improves treatment efficacy of breast cancer. This manuscript reports the development of an epidermal growth factor receptor-2 (HER-2) specific, bi-modal, dendrimer conjugate to enhance computed tomography (CT) and magnetic resonance imaging (MRI) of HER-2-positive breast cancer. This material employs generation 5 poly(amidoamine) dendrimers, encapsulated gold nanoparticles, chelated gadolinium, and anti-human HER-2 antibody to produce the nanoparticle contrast agent. Results Testing in two mouse tumor models confirms this contrast agent’s ability to image HER-2 positive tumors. Intravenous injection of this nanoparticle in mice bearing HER-2 positive mammary tumors significantly enhances MRI signal intensity by ~ 20% and improves CT resolution and contrast by two-fold. Results by flow cytometry and confocal microscopy validate the specific targeting of the conjugate and its internalization in human HER-2 positive cells. Conclusion These results demonstrate that this nanoparticle conjugate can efficiently target and image HER-2 positive tumors in vivo and provide a basis for the development of this diagnostic tool for early detection, metastatic assessment and therapeutic monitoring of HER-2 positive cancers.

The association between COVID-19 symptoms and antibody responses against SARS-CoV-2 is poorly characterized. We analyzed antibody levels in individuals with known SARS-CoV-2 infection to identify potential antibody-symptom associations. Convalescent plasma from 216 SARS-CoV-2 RNA+ individuals with symptomatology information were tested for the presence of IgG to the spike S1 subunit (Euroimmun ELISA), IgG to receptor binding domain (RBD, CoronaCHEK rapid test), and for IgG, IgA, and IgM to nucleocapsid (N, Bio-Rad ELISA). Logistic regression was used to estimate the odds of having a COVID-19 symptom from the antibody response, adjusting for sex and age. Cough strongly associated with antibodies against S1 (adjusted odds ratio [aOR] = 5.33; 95% CI from 1.51 to 18.86) and RBD (aOR = 4.36; CI 1.49, 12.78). In contrast, sore throat significantly associated with the absence of antibodies to S1 and N (aOR = 0.25; CI 0.08, 0.80 and aOR = 0.31; 0.11, 0.91). Similarly, lack of symptoms associated with the absence of antibodies to N and RBD (aOR = 0.16; CI 0.03, 0.97 and aOR = 0.16; CI 0.03, 1.01). Cough appeared to be correlated with a seropositive result, suggesting that SARS-CoV-2 infected individuals exhibiting lower respiratory symptoms generate a robust antibody response. Conversely, those without symptoms or limited to a sore throat while infected with SARS-CoV-2 were likely to lack a detectable antibody response. These findings strongly support the notion that severity of infection correlates with robust antibody response.

Examining non-sport-related cognitive tasks of attention and executive control in skilled athletes may provide insight into the acquisition of highly specific skills developed in experts as well as help identify successful performance in sport. Through a cross-sectional design, this study examined performance on aspects of attention and executive control among varsity athletes playing soccer (strategic sport) or track & field (static sport) using a computerized test of attention and executive control. Ninety-seven university athletes participating in soccer (n = 50) or track and field (n = 47) were included in the study. Domains of attention and executive control were examined using the Attention Network Test-Interactions (ANT-I). Mean reaction time (RT) and intra-individual variability (IIV) were compared between groups as measures of performance speed and performance stability respectively. Soccer players demonstrated overall faster RTs (p = 0.0499; ηp2 = .04) and higher response accuracy (p = .021, d = .48) on the ANT-I compared to track and field athletes. Faster RTs were observed for soccer players when presented with an alerting tone (p = .029, d = .45), valid orienting cue (p = .019, d = .49) and incongruent flanker (p = .031, d = .45). No significant group differences were observed in IIV (p = .083, d = .36). Athletes engaging in strategic sports (i.e., soccer) demonstrated faster performance under test conditions that required higher vigilance and conflict resolution. These findings suggest that engagement in strategic sports is associated with enhanced performance on non-sport-related cognitive tasks of attention and executive control.

Studies by the Division of Pomology at Davis, to determine the value of blackberry varieties for commercial planting— their promise as parental material in a breeding program—includes the new shiny type of the Boysen variety here described for the first time.

Fibrinogen is essential for blood coagulation. The C-terminus of the fibrinogen α-chain (αC-region) is composed of an αC-domain and αC-connector. Two recombinant fibrinogen variants (α390 and α220) were produced to investigate the role of subregions in modulating clot stability and resistance to lysis. The α390 variant, truncated before the αC-domain, produced clots with a denser structure and thinner fibres. In contrast, the α220 variant, truncated at the start of the αC-connector, produced clots that were porous with short, stunted fibres and visible fibre ends. These clots were mechanically weak and susceptible to lysis. Our data demonstrate differential effects for the αC-subregions in fibrin polymerisation, clot mechanical strength, and fibrinolytic susceptibility. Furthermore, we demonstrate that the αC-subregions are key for promoting longitudinal fibre growth. Together, these findings highlight critical functions of the αC-subregions in relation to clot structure and stability, with future implications for development of novel therapeutics for thrombosis.