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2. Evaluating the performance of conventional DAF and PosiDAF processes for cyanobacteria separation at a pilot plant scale

Author

R. K. L. Yap, N. R. H. Rao, M. Holmes, M. Whittaker, R. M. Stuetz, B. Jefferson, V. Bulmuş, W. L. Peirson, and R. K. Henderson

Subjects
algae, biomass, flotation, harvesting, waste stabilisation pond, River, lake, and water-supply engineering (General), TC401-506, Water supply for domestic and industrial purposes, TD201-500
Abstract

In this work, a commercially available water treatment polymer poly(N,N-diallyl-N,N-dimethylammonium chloride) (PDADMAC) and a hydrophobically modified polymer (HMP) designed to adhere to bubble surfaces were applied for the first time in the novel Posi-dissolved air flotation process (PosiDAF) that uses polymer-modified bubbles, at pilot-scale for the treatment of waste stabilisation pond samples rich in algae. It was found that PDADMAC in PosiDAF gave comparable removal to that achieved using conventional DAF at >95% cell separation. Furthermore, the float layer was more uniform and thicker with up to 8% solid contents compared to conventional DAF, which comprised discrete floc clusters with an average solid concentration of ∼4.1%. In contrast to the use of PDADMAC, the application of the HMP did not achieve similarly good separation at pilot scale. It was hypothesised that this may be due to the micellisation of the HMP on the bubble surface, creating unstable bubbles that coalesced and prevented polymer–bubble–cell interactions, which are crucial for effective cell separation. On comparison of the costs of PosiDAF and conventional DAF, it was found that PosiDAF resulted in cost-savings of up to 74% due to low chemical consumption. In summary, PosiDAF reduced chemical cost and increased solid contents in the metal-free float. HIGHLIGHTS Effective translation of PosiDAF from laboratory to pilot-scale is achieved.; PosiDAF float layer is structurally coherent compared to the conventional DAF float layer.; Compared to conventional DAF, PosiDAF can reduce 74% costs due to low chemical use.;

Published
2022
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5. Proof Repair Infrastructure for Supervised Models: Building a Large Proof Repair Dataset

Author

Tom Reichel and R. Wesley Henderson and Andrew Touchet and Andrew Gardner and Talia Ringer, Reichel, Tom, Henderson, R. Wesley, Touchet, Andrew, Gardner, Andrew, Ringer, Talia, Tom Reichel and R. Wesley Henderson and Andrew Touchet and Andrew Gardner and Talia Ringer, Reichel, Tom, Henderson, R. Wesley, Touchet, Andrew, Gardner, Andrew, and Ringer, Talia

Abstract

We report on our efforts building a new, large proof-repair dataset and benchmark suite for the Coq proof assistant. The dataset is made up of Git commits from open-source projects with old and new versions of definitions and proofs aligned across commits. Building this dataset has been a significant undertaking, highlighting a number of challenges and gaps in existing infrastructure. We discuss these challenges and gaps, and we provide recommendations for how the proof assistant community can address them. Our hope is to make it easier to build datasets and benchmark suites so that machine-learning tools for proofs will move to target the tasks that matter most and do so equitably across proof assistants.

Published
2023
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8. Application of a combination of oxidants improves treatment performance for NOM and manganese

Author

X. Chu, A. Agostino, N. R. H. Rao, S. Moradi, H. Bustamante, K. Power, R. K. Henderson, and G. L. Leslie

Subjects
Environmental Engineering, Water Science and Technology
Abstract

Systematic evaluation of seven oxidant combinations for pre and post coagulation in direct filtration provides guidance on maximising NOM and manganese removal without increasing DBP formation.

Published
2022
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10. TI-Stan: Adaptively Annealed Thermodynamic Integration with HMC †

Author

R. Wesley Henderson and Paul M. Goggans

Subjects
model comparison, mcmc, thermodynamic integration, hmc, General Works
Abstract

We present a novel implementation of the adaptively annealed thermodynamic integration technique using Hamiltonian Monte Carlo (HMC). Thermodynamic integration with importance sampling and adaptive annealing is an especially useful method for estimating model evidence for problems that use physics-based mathematical models. Because it is based on importance sampling, this method requires an efficient way to refresh the ensemble of samples. Existing successful implementations use binary slice sampling on the Hilbert curve to accomplish this task. This implementation works well if the model has few parameters or if it can be broken into separate parts with identical parameter priors that can be refreshed separately. However, for models that are not separable and have many parameters, a different method for refreshing the samples is needed. HMC, in the form of the MC-Stan package, is effective for jointly refreshing the ensemble under a high-dimensional model. MC-Stan uses automatic differentiation to compute the gradients of the likelihood that HMC requires in about the same amount of time as it computes the likelihood function itself, easing the programming burden compared to implementations of HMC that require explicitly specified gradient functions. We present a description of the overall TI-Stan procedure and results for representative example problems.

Published
2019
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13. High resolution TCSPC imaging of diffuse light with a one-dimensional SPAD array scanning system

Author

E. P. McShane, H. K. Chandrasekharan, A. Kufcsák, N. Finlayson, A. T. Erdogan, R. K. Henderson, K. Dhaliwal, R. R. Thomson, and M. G. Tanner

Subjects
Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Atomic and Molecular Physics, and Optics, Optics (physics.optics), Physics - Optics
Abstract

We report a time-resolved single photon counting (TCSPC) imaging system based on a line-scanning architecture. The system benefits from the high fill-factor, active area, and large dimension of an advanced CMOS single photon avalanche diode (SPAD) array line-sensor. A two-dimensional image is constructed using a moving mirror to scan the line-sensor field-of-view (FOV) across the target, to enable the efficient acquisition of a two-dimensional 0.26 Mpixel TCSPC image. We demonstrate the capabilities of the system for TCSPC imaging and locating objects obscured in scattering media - specifically to locate a series of discrete point sources of light along an optical fibre submerged in a highly scattering solution. We demonstrate that by selectively imaging using early arriving photons which have undergone less scattering than later arriving photons, our TCSPC imaging system is able to locate the position of discrete point sources of light than a non-time-resolved imaging system., 12 pages, 5 figures submitted to Optica: Optics Express

Published
2022
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14. Estimating biofuel contaminant concentration from 4D ERT with mixing models

Author

D R, Glaser, R D, Henderson, D D, Werkema, T J, Johnson, and R J, Versteeg

Subjects
Soil, Ethanol, Sand, Biofuels, Environmental Chemistry, Silicon Dioxide, Water Pollutants, Chemical, Article, Environmental Monitoring, Water Science and Technology
Abstract

We present the results of a lab-scaled feasibility study to assess the performance of electrical resistivity tomography for detection, characterization, and monitoring of fuel grade ethanol releases to the subsurface. Further, we attempt to determine the concentration distribution of the ethanol from the electrical resistivity tomography data using mixing-models. Ethanol is a renewable fuel source as well as an oxygenate fuel additive currently used to replace the known carcinogen methyl tert-butyl ether; however, ethanol is preferentially biodegraded and a cosolvent. When introduced to areas previously impacted by nonethanol-based fuels, it will facilitate the persistence of carcinogenic fuel compounds like benzene and ethylbenzene, as well as remobilize them to the ground water. These compounds would otherwise be retained in the soil column undergoing active or passive remediation processes such as soil vapor extraction or natural attenuation. Here, we introduce ethanol to a saturated Ottawa sand in a tank instrumented for four-dimensional geoelectrical measurements. Forward model results suggest pure phase ethanol released into a water saturated silica sand should present a detectable target for electrical resistivity tomography relative to a saturated silica sand only. We observe the introduction of ethanol to the closed hydraulic system and subsequent migration over the duration of the experiment. One-dimensional and three–dimensional temporal data are assessed for the detection, characterization, and monitoring of the ethanol release. Results suggest one-dimensional geoelectrical measurements may be useful for monitoring a release, while three-dimensional geoelectrical field imaging would be useful to characterize, monitor, and design effective remediation approaches for an ethanol release, assuming field conditions do not preclude the application of geoelectrical methods. We then attempt to use predictive mixing models to calculate the distribution of ethanol concentration within the measurement domain. For this study we examine four different models: a nested parallel mixing model, a nested cubic mixing model, the complex refractive index model (CRIM), and the Lichtenecker-Rother (L-R) model. The L-R model, modified to include an electrical formation factor geometry term, provided the best agreement with expected EtOH concentrations.

Published
2022
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15. Erratum to: Two novel chromosomal loci influence cultivar-specific nodulation failure in the interaction between strain ANU794 and subterranean clover cv. Woogenellup

Author

LF Roddam, Michael A. Djordjevic, and Wendy R. Lewis-Henderson

Subjects
Genetics, Rhizobiaceae, Mutant, food and beverages, Locus (genetics), Plant Science, Biology, biology.organism_classification, medicine.disease_cause, Rhizobium leguminosarum, medicine, Rhizobium, Transposon mutagenesis, Insertion sequence, Agronomy and Crop Science, Gene
Abstract

The nodulation failure resulting from the interaction between Rhizobium leguminosarum biovar trifolii strain ANU794 and the Trifolium subterraneum cv. Woogenellup was examined by transposon mutagenesis to resolve whether multiple determinants were involved in cultivar-specificity. Three new transposon-induced mutants of ANU794 (W72, W78 and W710) with significantly enhanced nodulation ability on cv. Woogenellup were identified. The W72 and W78 mutations are chromosomally-located, whereas the W710 mutation isplasmid-located. The ethylene synthesis inhibitor, aminoethoxyvinylglycine, fails to enhance the nodulation ability of ANU794, ANU7943 (csn1::Tn5) and W78 on cv. Woogenellup, but enhances the nodulation ability of W72,W710 and ANU7941 (nodM::Tn5). DNA sequencing of the W78 locus reveals strong homology to an unknown Mycobacterium open reading frame, and to several bacterial non-haem chloroperoxidases. The previously identified csn1 locus showed homology to the 50S ribosomal protein, L9, with the Tn5 insertion being located in the 5′-untranslated region. The results suggest that cultivar-specificity is mediated by at least two independent mechanisms or determinants, and not by a simple gene-for-gene interaction. The role of ethylene in cultivar specificity is discussed. Cultivar-specific interactions may prove useful in identifying pathways involved in efficient nodule formation and plant-microbe interactions.

Published
2020

16. Legislative: COVID-19 and Mental Health: The Inevitable Impact

Author

Marcus M. S. N. R. N. Henderson

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Legislature, Mental illness, medicine.disease, Mental health, Substance abuse, Issues, ethics and legal aspects, Workforce, Pandemic, medicine, Social isolation, medicine.symptom, Psychiatry, Psychology
Abstract

2013T The Substance Abuse and Mental Health Services Administration (SAMHSA) estimates the prevalence of mental illness in adults at close to 50 million (SAMHSA 20191 and an estimated 7 7 million children have also experienced mental illness (Whitney ¾ Peterson 2019T Despite these numbers, fewer than half of adults and children receive necessary mental health services (SAMHSA 2019: Compounded by the effects of social isolation, quarantine, critically ill family and friends, death, and economic stress, the challenges of mental illness may be quietly increasing (Pfefferbaum ¾ North 2020T Major media outlets across the nation have been reporting the widespread effects of the COVID-19 pandemic and its impact on the economy, health, and society [ ]the emphasis has been placed on ensuring the capacity to care for the influx of patients with COVID-19, limiting the system's ability to adequately care for patients' mental health needs due to reduced bed availability in inpatient settings (Choi et al , 2020J While many alternative models of care (e g , accountable care organizations [ACOs], patient centered medical homes [PCMHs]) incentivized through the Affordable Care Act of 2010 encouraged the integration of primary care and mental health services, the declining workforce and maldistribution of providers (e g , urban vs rural) pose barriers to this effort (Olfson, 20161

Published
2020
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17. Low Loss Square Grid Dielectric Waveguide

Author

N. Aflakian, T. LaFave, R. M. Henderson, K. K. O, and D. L. MacFarlane

Subjects
Square tiling, Interconnection, Electric power transmission, Materials science, business.industry, Extremely high frequency, Broadband, Physics::Optics, Optoelectronics, Polarization-division multiplexing, business, Dielectric waveguides, Cladding (fiber optics)
Abstract

A novel square, broadband, and low loss holey core/cladding waveguide has been designed for chip-to-chip communications. The square grid geometry allows for polarization division multiplexing with minimum cross-talk. The design shows a three-fold loss reduction compared to a solid core waveguide.

Published
2020
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18. MiCheck prostate blood test for aggressive prostate cancer designed for the clinical lab setting

Author

Neal D. Shore, Christopher Michael Pieczonka, R. Jonathan Henderson, James L. Bailen, Daniel R. Saltzstein, Raoul S. Concepcion, David Gillatt, Daniel W. Chan, Douglas Campbell, Yanling Lu, Thao Ho Le, Niantao Deng, and Bradley Walsh

Subjects
Cancer Research, Oncology
Abstract

229 Background: Clinicians want a more accurate diagnostic test to identify patients for prostate biopsy. We have previously described the development of a Luminex based test for aggressive prostate cancer (MiCheck). To facilitate widespread deployment of MiCheck on standard clinical chemistry analysers such as Roche Cobas and Abbott ARCHITECT/Alinity systems, we have performed additional analytical validation and model development using the MiCheck-01 clinical samples. A novel algorithm, termed MiCheck Prostate, was developed to differentiate aggressive prostate cancer (Gleason 3+4 or above) from non-aggressive (GS3+3) or no cancer patients. Methods: Serum protein biomarkers were measured in 317 samples from the MiCheck-01 clinical trial using either Luminex Multiplex kits, Abbott ARCHITECT or Beckmann Coulter systems. Logistic regression models were used to select best analytes, then Monte Carlo cross-validation was applied to avoid overfitting. A final model was selected from the cross-validation models with best test specificity at 95% sensitivity. The MiCheck-01 samples were later all measured on a standard Abbott ARCHITECT system using commercial ARCHITECT IVD tests. The best cross-validated model was developed and the results compared to those obtained from the mixed analyte platforms using ROC curve analysis. Results: The MiCheck Prostate algorithm was developed to maximise discrimination between aggressive prostate cancer and no cancer or non-aggressive cancer. The MiCheck Prostate algorithm reports a percentage risk of aggressive prostate cancer on biopsy. MiCheck Prostate is a logistic regression algorithm that combines three serum protein markers and one clinical factor and was derived using data from the MiCheck-01 trial. The algorithm gave an AUC of 0.82, with a 48% specificity at a 95% sensitivity cutpoint, with a negative predictive value of 94% for GS3+4 and higher cancers. The samples were later re-measured using all ARCHITECT immunoassays. Good correlations of each analyte across different measurement platforms was observed (Pearson’s R > 0.9). The algorithm was revalidated using the new set of analyte values. AUC of 0.82 for the detection of aggressive CaP, and sensitivity of 95%, specificity of 47% were obtained for the best model, showing no statistical difference to the previous best model derived from the mixed platforms. NPV of 94% for GS3+4 or higher cancers was maintained. Conclusions: The MiCheck Prostate test shows high sensitivity, specificity and NPV for the detection of aggressive prostate cancer. It uses analytes widely available on standard clinical chemistry analysers such as Abbott Architect and Roche Cobas, hence is simple to deploy in the laboratory setting. Studies are ongoing to confirm the MiCheck Prostate algorithm performance using additional clinical sample cohorts.

Published
2022
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19. Preserving Independent Urology: LUGPA's First Decade

Author

Neal D, Shore, Deepak A, Kapoor, Evan R, Goldfischer, David C, Chaikin, Earl L, Walz, R Jonathan, Henderson, Richard G, Harris, Robert D, Asinof, and Gary M, Kirsh

Subjects
Review
Published
2019

20. The Impact of Late Luteinizing Hormone-Releasing Hormone Agonist Dosing on Testosterone Suppression in Patients with Prostate Cancer: An Analysis of United States Clinical Data

Author

R. Jonathan Henderson, Przemyslaw Twardowski, Stuart Atkinson, Daniel P. Petrylak, Jason Hafron, Lucio N. Gordan, E. David Crawford, Thomas E. Keane, Maha Hussain, Neal D. Shore, Deborah M. Boldt-Houle, Raoul S. Concepcion, Richard G. Harris, A. Karim Kader, Celestia S. Higano, and Judd W. Moul

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Antineoplastic Agents, Hormonal, Urology, 030232 urology & nephrology, Gonadotropin-releasing hormone, Drug Administration Schedule, Medication Adherence, Androgen deprivation therapy, Gonadotropin-Releasing Hormone, 03 medical and health sciences, Prostate cancer, Young Adult, 0302 clinical medicine, Internal medicine, medicine, Humans, Testosterone, Dosing, Young adult, Aged, Retrospective Studies, Aged, 80 and over, Dose-Response Relationship, Drug, business.industry, Prostatic Neoplasms, Middle Aged, Prostate-Specific Antigen, medicine.disease, United States, Prostate-specific antigen, Endocrinology, Kallikreins, business, Hormone
Abstract

We evaluated the timeliness of androgen deprivation therapy dosing, the impact of dosing nonadherence on testosterone, and the frequency of testosterone and prostate specific antigen testing in patients with prostate cancer.We retrospectively analyzed the records of 22,860 patients with prostate cancer treated with luteinizing hormone-releasing hormone agonists. Analyses were done using 2 definitions of month, including a 28-day month (late dosing after day 28, 84, 112 or 168) and an extended month (late after day 32, 97, 128 or 194) for 1, 3, 4 and 6-month formulations, respectively. The prevalence of late dosing, associated testosterone values, and the frequency of testosterone and prostate specific antigen testing were assessed. Statistical significance was assessed with the unpaired t-test.Of the injections 84% and 27% were late for the 28-day and extended month analyses, respectively. For the 28-day month 60% and 29% of injections were late by more than 1 and more than 2 weeks, respectively. Of testosterone values 4% were greater than 50 ng/dl for early/on time injections using both definitions, and 15% and 27% were greater than 50 ng/dl when late, and for the 28-day month and the extended month, respectively. For early/on time vs late injections 22% vs 31% of testosterone values were greater than 20 ng/dl for the 28-day month and 21% vs 43% for the extended month. Mean testosterone was higher when lateLuteinizing hormone-releasing hormone agonists were frequently (84%) administered later than the schedules used in pivotal trials. Nearly half of the late testosterone values for the extended month were greater than 20 ng/dl and mean testosterone was almost double the castration level. Elevated testosterone remained unidentified with infrequent testing.

Published
2019

21. Association of the clinical cell-cycle risk score with metastasis after radiation therapy and identification of men with prostate cancer who can forgo combined androgen deprivation therapy

Author

Jonathan David Tward, Constantine Mantz, Neal D. Shore, Paul Nguyen, Isla Garraway, Carl A Olsson, Steve Pai-hsun Lee, Arthur Hung, R Jonathan Henderson, Stanley L. Liauw, David Raben, Michael D. Fabrizio, Daniel R. Saltzstein, Paul Yonover, Hiram Alberto Gay, Daniel Joseph Albertson, Tatjana Antic, Lauren Lenz, Steven Stone, and Todd Cohen

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Framingham Risk Score, business.industry, medicine.medical_treatment, Cell cycle, medicine.disease, Metastasis, Androgen deprivation therapy, Radiation therapy, Prostate cancer, Internal medicine, Medicine, business
Abstract

195 Background: This study evaluated the ability of the combined clinical cell-cycle risk score (CCR) to prognosticate the risk of prostate cancer metastasis in men receiving dose-escalated radiation therapy (RT) with or without androgen deprivation therapy (ADT). Methods: The CCR score is a validated model that combines the cell cycle progression score (CCP) with the UCSF Cancer of the Prostate Risk Assessment score (CAPRA). The CCR score and a CCR-based multimodality threshold score (2.112) were evaluated in a retrospective, multi-institutional cohort of men with National Comprehensive Cancer Center (NCCN) intermediate- or high-risk localized disease (N = 741) who received single (RT) or multimodality therapy (ADT with RT). Effects of prognostic variables were analyzed using Kaplan-Meier and Cox regression methods. Results: Median follow-up was 5.9 years. CCR predicted metastasis [hazard ratio (HR) 2.21, 95% Confidence Interval (CI) 1.70-2.87, p < 0.001]. The CCR score was a better prognosticator of metastasis (C-index 0.78) than either NCCN-risk group (C-index 0.70), CAPRA score (C-index 0.71), or CCP score (C-index 0.69) alone. In bivariate analyses, the CCR score remained highly prognostic for metastasis when comparing any ADT vs none (HR 2.19, 95% CI 1.62 to 2.97, p < 0.001), ADT duration as a continuous variable (HR 2.05, 95% CI 1.54-2.72, p < 0.001), or ADT use given as less than or at the recommended duration for each NCCN risk group (HR 2.22, 95% CI 1.71-2.88, p < 0.001). Men with CCR scores either below or above the threshold (2.112) had a 10-year risk of metastasis of 4.2% and 25.3%, respectively. For men below the threshold receiving RT alone versus RT+ADT, the 10-year risk of metastasis was 4.2% and 3.9%, respectively. Conclusions: CCR is a highly precise and accurate predictor of metastasis in men undergoing dose-escalated RT, with or without ADT. CCR adds clinically actionable information relative to guideline recommended therapies that are based on NCCN risk groups or CAPRA alone. Men with scores below the multimodality threshold may not significantly reduce their 10-year risk of metastasis with the addition of ADT.

Published
2021
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22. Development and evaluation of the MiCheck test for aggressive prostate cancer

Author

Bradley J. Walsh, James Bailen, Rachel A. Levin, Sandra Wissmueller, Daniel W. Chan, Daniel Saltzstein, Raoul S. Concepcion, David Gillatt, Christopher Michael Pieczonka, Julie J. Ruterbusch, Jennifer L. Beebe-Dimmer, Douglas Campbell, Thao Ho Le, Neal D. Shore, and R. Jonathan Henderson

Subjects
Male, Oncology, medicine.medical_specialty, Prostate biopsy, Urology, 030232 urology & nephrology, Logistic regression, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Prostate, Internal medicine, Biopsy, medicine, Humans, Blood test, Aged, Aged, 80 and over, Hematologic Tests, medicine.diagnostic_test, business.industry, Area under the curve, Prostatic Neoplasms, Middle Aged, Prostate-Specific Antigen, medicine.disease, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Biomarker (medicine), Neoplasm Grading, business, Monte Carlo Method
Abstract

Background A clinical need exists for a biomarker test to accurately delineate aggressive prostate cancer (AgCaP), and thus better assist clinicians and patients decision-making on whether to proceed to prostate biopsy. Objectives To develop a blood test for AgCaP and compare to PSA, %free PSA, proPSA, and prostate health index (PHI) tests. Design, settings and participants Patient samples from the MiCheck-01 trial were used for development of the MiCheck test. Methods Serum analyte concentrations for cellular growth factors were determined using a custom-made Luminex-based R&D Systems multianalyte kit. Outcome measurements and statistical analysis Bayesian model averaging and random forest approaches were used to identify clinical factors and growth factors able to distinguish between men with AgCaP (Gleason Score [GS] ≥3+4) from those with non-AgCaP (GS 3+3). Logistic regression and Monte Carlo cross-validation identified variable combinations in order to able to maximize differentiation of AgCaP from non-AgCaP. Results The MiCheck logistic regression model was developed and comprises the following variables: serum prostate-specific antigen (PSA), patient age, Digital Rectal Exam (DRE) status, Leptin, IL-7, vascular endothelial growth factor, and Glypican-1. The model differentiated AgCaP from non-AgCaP with an area under the curve of 0.83 and was superior to PSA, %free PSA and PHI in all patient groups, regardless of PSA range. Applying the MiCheck test to all evaluable biopsy patients from the MiCheck-01 study demonstrated that up to 30% of biopsies could be avoided while delaying diagnosis of only 6.8% of GS ≥3+4 cancers, 5% of GS ≥4+3 cancers and no cancers of GS 8 or higher. Conclusions The MiCheck test outperforms PSA, %free PSA and PHI tests in differentiating AgCaP vs. non-AgCaP patients. The MiCheck test could result in a significant number of biopsies being avoided with a low number of patients experiencing a delayed diagnosis.

Published
2020
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23. A comparison of prostate health index, total PSA, %free PSA, and proPSA in a contemporary US population—The MiCheck-01 prospective trial

Author

Sandra Wissmueller, Neal D. Shore, Daniel Saltzstein, Robert Borotkanics, Julie J. Ruterbusch, Thomas A. Paivanas, Raoul S. Concepcion, Christopher Michael Pieczonka, Jennifer L. Beebe-Dimmer, Arletta van Breda, Thao Ho Le, Philip Prah, Douglas Campbell, R. Jonathan Henderson, Bradley J. Walsh, Rachel A. Levin, and James Bailen

Subjects
Adult, Male, medicine.medical_specialty, Health Status, Urology, Population, 030232 urology & nephrology, urologic and male genital diseases, Logistic regression, Central Pathology Review, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Prostate, Biopsy, Humans, Medicine, Prospective Studies, education, Aged, Aged, 80 and over, education.field_of_study, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Reproducibility of Results, Middle Aged, Prostate-Specific Antigen, medicine.disease, United States, Prostate-specific antigen, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, business
Abstract

Background Increasing numbers of patients are presenting with aggressive prostate cancer (CaP); therefore, there exists a need to optimally identify these patients pre-biopsy. Objectives To compare the accuracy of total prostate specific antigen (PSA), %free PSA, and prostate health index (PHI) to differentiate between patients without CaP, with non-aggressive (Gleason 3 + 3, non-AgCaP) and with aggressive (Gleason ≥ 3 + 4, AgCaP) in a contemporary US population. Design, settings, and participants Serum samples were collected from 332 US patients scheduled for biopsy due to an elevated age-adjusted PSA. Site and Central biopsy pathologic assessment were performed. Outcome measurements and statistical analysis Testing of PSA, free PSA, proPSA, and PHI was performed along with central pathology review. Test performance using logistic regression analysis for differentiating CaP from non-CaP as well as non-AgCaP from AgCaP was evaluated. Results and limitations Central pathology review resulted in 32 upgrades including 14 Gleason 3 + 3 scores being upgraded to AgCaP with final distribution of 148 no-CaP, 64 non-AgCaP, and 120 AgCaP patients. Receiver operator curve (ROC) analysis of the different tests showed that PHI performed best at differentiating CaP from no-CaP subjects (area under the receiver operator curve 0.79). In contrast, the different tests were essentially equivalent in differentiating AgCaP vs. non-AgCaP. Conclusions In this recent US study of prebiopsy patients we observed a high proportion of AgCaP patients consistent with previous studies in contemporary US populations. Central Gleason review is recommended for multi-institutional studies comparing biomarkers. PHI was superior to PSA, free PSA, %free PSA, and proPSA in detecting CaP in this population but was not superior at differentiating AgCaP from non-AgCaP.

Published
2020
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24. Elastic and Inelastic Behavior of Precast Concrete Piles and Cast-in-Shell Steel Piles in Reinforced Concrete Caps

Author

Taylor B. Kidwell, Tim Huff, R. Craig Henderson, and Rebekah F. Kerley

Subjects
business.industry, 0211 other engineering and technologies, Shell (structure), 020101 civil engineering, 02 engineering and technology, Building and Construction, Structural engineering, Reinforced concrete, 0201 civil engineering, Arts and Humanities (miscellaneous), Precast concrete, 021105 building & construction, business, Geology, Civil and Structural Engineering
Published
2018
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25. Using the Z-Order Curve for Bayesian Model Comparison

Author

R. Wesley Henderson and Paul M. Goggans

Subjects
symbols.namesake, Transformation (function), Computation, symbols, Applied mathematics, Z-order curve, Markov chain Monte Carlo, Hilbert curve, Parameter space, Bayesian inference, Integer (computer science), Mathematics
Abstract

BayeSys is an MCMC-based program that can be used to perform Bayesian model comparison for problems with atomic models. To sample distributions with more than one parameter, BayeSys uses the Hilbert curve to index the multidimensional parameter space using one very large integer. While the Hilbert curve maintains locality well, computations to translate back and forth between parameter coordinates and Hilbert curve indexes are time-consuming. The Z-order curve is an alternative SFC with faster transformation algorithms. This work presents an efficient bitmask-based algorithm for performing the Z-order curve transformations for an arbitrary number of parameter space dimensions and integer bit-lengths. We compare results for an exponential decay separation problem evaluated using BayeSys with both the Hilbert and Z-order curves. We demonstrate that no appreciable precision penalty is incurred by using the Z-order curve, and there is a significant increase in time efficiency.

Published
2018
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26. Design of a Radial TPC for Antihydrogen Gravity Measurement with ALPHA-g

Author

Skyler Freeman, K. Olchanski, S. Menary, R. S. Henderson, D. Bishop, L. Kurchaninov, Matthew Grant, D. R. Gill, Fabrice Retiere, P. Lu, M. C. Fujiwara, Pierre-Andre Amaudruz, and A. Capra

Subjects
Physics, Physics::General Physics, Physics - Instrumentation and Detectors, Annihilation, Time projection chamber, 010308 nuclear & particles physics, Detector, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, Particle detector, Nuclear physics, Gravitation, Antimatter, 0103 physical sciences, Gravitational interaction of antimatter, Physics::Atomic and Molecular Clusters, Physics::Atomic Physics, Detectors and Experimental Techniques, 010306 general physics, Antihydrogen, physics.ins-det
Abstract

The gravitational interaction of antimatter and matter has never been directly probed. ALPHA-g is a novel experiment that aims to perform the first measurement of the antihydrogen gravitational mass. A fundamental requirement for this new apparatus is a position sensitive particle detector around the antihydrogen trap which provides information about antihydrogen annihilation location. The proposed detector is a radial Time Projection Chamber, or \textit{rTPC}, whose concept is being developed at TRIUMF. A simulation of the detector and the development of the reconstruction software, used to determine the antihydrogen annihilation point, is presented alongside with the expected performance of the rTPC., 6 pages, 4 figures, LEAP2016

Published
2017
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27. Square dielectric interconnect for chip-to-chip THz communication

Author

N. Aflakian, T. LaFave, R. M. Henderson, K. K. O, and D. L. MacFarlane

Subjects
Interconnection, Optics, Materials science, business.industry, Terahertz radiation, Coupling efficiency, Physics::Optics, Free space, Dielectric, Radiation mode, business, Cladding (fiber optics), Chip
Abstract

A square holey cladding waveguide is designed and fabricated to support TE and TM polarizations for 180 GHz to 360 GHz chip-to-chip communication. The mode profile and normalized output power of the waveguide are simulated. A fabricated waveguide is tested using a vector network analyzer for mode mapping and loss measurements. The mode profile was mapped using a 250 μm pinhole stepped across the waveguide cross section. The waveguide loss is measured using a free space dielectric material characterization method. Here a taper with an aperture comparable to the core size was used. The taper provides easy alignment and higher coupling efficiency.

Published
2017
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28. Viewpoint survey of mental health service users’ experiences of discrimination in England 2008–2012

Author

Vanessa Pinfold, Graham Thornicroft, Diana Rose, Paul Williams, R. C. Henderson, Martin Webber, Sara Evans-Lacko, Sarah Hamilton, and Elizabeth Corker

Subjects
Adult, Male, Mental Health Services, Health (social science), Social Psychology, Social stigma, Epidemiology, Social Stigma, Poison control, Logistic regression, Suicide prevention, Occupational safety and health, Mental health service users, Health(social science), Odds, Interviews as Topic, Social capital, Welfare benefits, Surveys and Questionnaires, Environmental health, Injury prevention, Humans, Medicine, Original Paper, business.industry, Mental Disorders, Middle Aged, Mental health, Stigma, Psychiatry and Mental health, England, Female, Mental health discrimination, business, Prejudice
Abstract

Purpose Research suggests levels of discrimination among mental health service users in England are high, but fell over the course of the first phase of the Time to Change programme to reduce stigma and discrimination (2008–2011). The aim of this study was to determine changes in discrimination levels, both overall and by the area of life in which discrimination is experienced, since Time to Change began and over the first year of its second phase (2011–2012). Method Separate samples of mental health service users were interviewed annually from 2008 to 2012 using the Discrimination and Stigma Scale. In 2011 and 2012, social capital was also measured using the Resource Generator-UK. Results Sample percentages of participants reporting the experience of discrimination in one or more life areas for years 2008–2012 were 91.4, 86.5, 86.2, 87.9 and 91.0 %, respectively. A multivariable logistic regression model was performed to test for significant differences by study year, weighted to match the study population and adjusted for employment status and diagnosis as potential confounding factors. The odds of reporting discrimination in one or more life areas were significantly lower as compared to 2008 for all subsequent years except for 2012 (0.76, 95 % CI 0.49–1.19). However, a weighted multiple regression model provided evidence of decreased mean overall discrimination in 2012 as compared to 2008 (mean decrease −7.57, 95 % CI −11.1 to −4.0, p

Published
2014
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29. Efficacy and Safety of the Coadministration of Tadalafil Once Daily with Finasteride for 6 Months in Men with Lower Urinary Tract Symptoms and Prostatic Enlargement Secondary to Benign Prostatic Hyperplasia

Author

David G. Wong, R. Jonathan Henderson, Sebastian Zepeda, Sebastian Sorsaburu, Lars Viktrup, Adolfo Casabé, Claus G. Roehrborn, Carsten Henneges, Luigi F. Da Pozzo, Casabé, A, Roehrborn, C, DA POZZO, L, Zepeda, S, Henderson, R, Sorsaburu, S, Henneges, C, Wong, D, and Viktrup, L

Subjects
Male, medicine.medical_specialty, Urology, Urinary system, Prostatic Hyperplasia, Tadalafil, chemistry.chemical_compound, Double-Blind Method, Lower Urinary Tract Symptoms, Prostate, Lower urinary tract symptoms, Humans, Medicine, Aged, Aged, 80 and over, business.industry, tadalafil , erectile dysfunction, BPH, Finasteride, Middle Aged, Hyperplasia, medicine.disease, Treatment Outcome, medicine.anatomical_structure, Erectile dysfunction, chemistry, Urological Agents, Drug Therapy, Combination, International Prostate Symptom Score, business, Carbolines, medicine.drug
Abstract

Purpose Medical treatment for men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia is 5α-reductase inhibitor monotherapy or coadministration with an α-blocker. We assessed the effects of tadalafil 5 mg coadministered with finasteride 5 mg during 26 weeks on lower urinary tract symptoms and sexual symptoms. Materials and Methods In an international, randomized, double-blind, parallel study of men 45 years old or older who were 5α-reductase inhibitor naïve and had an I-PSS (International Prostate Symptom Score) of 13 or greater and prostate volume 30 ml or greater, 350 were treated with placebo/finasteride and 345 received tadalafil/finasteride for 26 weeks. Changes in lower urinary tract symptoms secondary to benign prostatic hyperplasia were assessed with the I-PSS, erectile dysfunction improvements were assessed with the IIEF-EF (International Index of Erectile Function-Erectile Function) in sexually active men and safety was assessed by evaluating adverse events. Results Least squares mean changes from baseline in I-PSS after 4, 12 and 26 weeks of tadalafil/finasteride coadministration were -4.0, -5.2 and -5.5, respectively. Corresponding values for placebo/finasteride coadministration were -2.3, -3.8 and -4.5 (p ≤0.022 at all visits favoring tadalafil/finasteride coadministration). I-PSS subscores (storage and voiding) and quality of life index were also numerically improved with tadalafil/finasteride coadministration. Least squares mean changes from baseline in IIEF-EF with tadalafil/finasteride coadministration were 3.7 after 4 weeks, and 4.7 after 12 and 26 weeks. Corresponding values for placebo/finasteride coadministration were -1.1, 0.6 and -0.0 (p

Published
2014
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30. Campaigns to reduce mental illness stigma in Europe: a scoping review

Author

R. C. Henderson, Nicholas Jones, Rohan Borschmann, and Neil Greenberg

Subjects
Potential impact, business.industry, Target groups, Stigma (botany), Public relations, Stigma reduction, Mental illness, medicine.disease, Mental health, Psychiatry and Mental health, Intervention (counseling), medicine, Duration (project management), business, Social psychology
Abstract

Summary Background: Evidence has emerged in recent decades about effective and ineffective methods to reduce mental illness related stigma and discrimination. As more European countries start national anti-stigma campaigns, there is potentially more to learn from their experiences, but also a risk that, with such rapid developments, lessons may be missed. Aim: This scoping review aims to identify and discuss European stigma reduction campaigns conducted to date. Methods: We searched electronic databases, hand-searched reference lists of identified articles and contacted stigma experts to enquire about ongoing initiatives. Results: We identified anti-stigma campaigns in 21 European countries and regions. We found considerable variation in their content, delivery formats, duration and target groups. Conclusions: Although anti-stigma campaigns have been implemented in many European countries, the level of attention paid to sharing lessons learned is variable. It is vital that campaigns are evaluated, to maximise their potential impact both on the target population, and that the findings are disseminated widely to allow international learning.

Published
2014
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31. Search for displaced muonic lepton jets from light Higgs boson decay in proton–proton collisions at s=7 TeV with the ATLAS detector

Author

Xuai Zhuang, Samira Hassani, C. Da Via, J. Boek, Gregor Kasieczka, G. Bruni, Stefanie Adomeit, D. Liu, J. Keung, F. Etienne, Bellisario Esposito, G. Usai, B. Zabinski, Alexandra Tudorache, B. Butler, J. Hoffman, Frank Siegert, M. C. Tamsett, P. P. Allport, F. Koetsveld, T. Perez Cavalcanti, G. Zevi della Porta, K. Korcyl, Michele Pinamonti, Volker Büscher, J. L. Holzbauer, M. Hauschild, W. Wiedenmann, A. Wilson, Tancredi Carli, Roberto Cardarelli, C. García, Bruno Galhardo, E. S. Kuwertz, Remi Lafaye, C. Mattravers, S. Cole, E. Devetak, Elliot Hughes, K. Whalen, F. Garberson, V. Perez Reale, P. Weigell, U. K. Yang, C. Cuenca Almenar, D. Paredes Hernandez, Peter Jenni, I. Chalupkova, G. Lenzen, C. Conta, A. Krasznahorkay, Gideon Bella, M. Strang, B. A. Schumm, L. Liu, D. Fassouliotis, Rohin Narayan, E. Perez Codina, S. Mahmoud, S. J. Wollstadt, Jean-Francois Grivaz, M. C. Hodgkinson, Lucio Cerrito, J. Colas, E. Paganis, Julien Maurer, H. J. Burckhart, R. D. Harrington, Si Xie, M. Lokajicek, Manuela Venturi, W. Lampl, E. B. Klinkby, I. Turk Cakir, Tomoe Kishimoto, T. Nattermann, R. Piegaia, D. Caforio, C. L. Lampen, Armin Michael Nairz, E. Benhar Noccioli, E. Williams, F. Crescioli, V. Vacek, James Shank, Christian Weiser, Paolo Laurelli, Barbara Liberti, Philippe Mermod, N. Benekos, L. E. Price, Jan Andre Stillings, M. Villa, J. T. Childers, J. Dodd, Veronique Boisvert, G. Darbo, W. Ji, K. Cranmer, L. Mendoza Navas, Maurice Garcia-Sciveres, S. Bahinipati, A. DʼOrazio, M. Atkinson, B. Gibbard, E. W. Varnes, P. de Jong, T. Kanno, P. Radloff, Vincent Hedberg, D. O. Savu, L. Serkin, Yasuyuki Okumura, M. Mechtel, Kunihiro Nagano, T. Yamazaki, Yury Smirnov, N. Massol, G. V. Ybeles Smit, M. Teinturier, C. T. Potter, Ludovico Pontecorvo, N. Amram, A. Borisov, Robert Clarke, K. Benslama, M. T. Dova, P. S. Wells, M. A. Pleier, P. S. Mangeard, F. M. Brochu, Flera Rizatdinova, W. Kozanecki, T. Loddenkoetter, O. Rosenthal, Imma Riu, J. Mechnich, C. H. Wang, Valerio Ippolito, E. A. Ouellette, R. Simoniello, S. Nemecek, Gabriella Gaudio, P. Nemethy, C. Del Papa, S. Eckweiler, A. Napier, B. Caron, J. Idarraga, D. Roda Dos Santos, C. Zeitnitz, A. Palma, M. A. Dufour, A. T. Watson, J. Grosse-Knetter, G. Jones, Yoichi Ikegami, S. Kortner, C. Suhr, J. Odier, J. A. Gray, S. White, M. Schernau, V. Kus, Thomas Müller, Xiaohu Sun, Vadim Bednyakov, M. R. Sutton, M. Yamada, R. Spiwoks, Rainer Bartoldus, P. Hansson, Daniel Muenstermann, S. Patricelli, F. Vives Vaque, O. Simard, F. Pastore, M. Keil, Timothy Knight Nelson, Marianna Testa, Mauro Citterio, C. Topfel, Alexander Cheplakov, S. P. Baranov, S. R. Hou, S. Errede, Mossadek Talby, Evgenia Panagiotopoulou, B. Demirkoz, L. N. Smirnova, Andrzej Olszewski, V. Bartsch, A. Barbaro Galtieri, R. St. Denis, W. Bhimji, S. Bethke, M. Lungwitz, Graeme Stewart, M. He, M. Vanadia, Mattias Ellert, H. Wellenstein, W. J. Murray, A. Beddall, C. Lapoire, D. M. Rebuzzi, Diane Cinca, T. J. Neep, Vladimir Nikolaenko, Sally Seidel, V. A. Kramarenko, Lydia Iconomidou-Fayard, Martin Johannes Schultens, Mariya Shiyakova, Danilo Giugni, Otmar Biebel, S. I. Buda, K. W. McFarlane, M. Werth, S. H. Robertson, A. Penson, Nikola Makovec, Gerjan Bobbink, M. Donadelli, Y. Suzuki, J. L. Lane, Stephen Burke, M. Goebel, W. Taylor, Pierre-Antoine Delsart, Patrick Fassnacht, I. Ludwig, A. D. Doxiadis, A. V. Akimov, M. Dwuznik, D. Fellmann, A. Nikiforov, W. Ehrenfeld, E. Nurse, P. M. Tuts, A. Gaponenko, D. A. A. Geerts, D. van der Ster, Donatella Cavalli, Y. Nagasaka, G. Siragusa, L. Aperio Bella, J. Tanaka, Y. Hernández Jiménez, M. A. Wildt, A. Petridis, N. S. Knecht, Karsten Köneke, E. von Toerne, Z. Czyczula, A. Onofre, A. I. Mincer, Nikolai Rusakovich, T. Mueller, C. J. Curtis, C. Xu, E. Berglund, G. H. Lewis, M. I. Scherzer, O. Jinnouchi, V. Khovanskiy, J. Yu, S. Viel, A. Gibson, S. A. Olivares Pino, Shih-Chieh Hsu, Gianluca Alimonti, Rainer Stamen, M. Schmitz, Christos Anastopoulos, S. Jakobsen, M. Neumann, Kevin M. Smith, Arthur Moraes, E. Graziani, Lucia Zanello, C. Biscarat, I. Gough Eschrich, D. Casadei, Andre Schoening, Barry King, G. F. Moorhead, F. Alessandria, C. M. Hawkes, N. Grau, A. K. Ciftci, A. Christov, Z. Zhao, Sigve Haug, Sergio Grancagnolo, Miriam Watson, Emmanuel Monnier, L. R. Flores Castillo, P. Federic, Kathy Pommès, Paolo Bagnaia, K. Chan, Mark Owen, A. T. H. Arce, M. Benoit, Zach Marshall, Nuno Filipe Castro, K. De, I. A. Christidi, V. Cindro, K. Tani, Douglas Schaefer, Alex Martyniuk, Marie-Hélène Genest, C. Rudolph, M. J. Oreglia, Arnaud Ferrari, W. Liebig, T. Vu Anh, G. Volpini, Shigeru Odaka, H. von Radziewski, U. Blumenschein, C. Dionisi, Elisabeth Petit, I. I. Tsukerman, Dan Pantea, Norbert Wermes, C. Belanger-Champagne, Marjorie Shapiro, Uli Schäfer, Soshi Tsuno, G. N. Taylor, J. Albert, Reyhaneh Rezvani, D. Jennens, T. Kawamoto, Frank Seifert, R. Engelmann, S. Brunet, M. Heller, O. Vitells, M. Ouchrif, Givi Sekhniaidze, Tomer Volansky, A. Di Simone, Jan Godlewski, Tracey Berry, E. Dawe, K. Toms, A. Vartapetian, F. Gianotti, A. Zaytsev, Ryan Reece, S. Albrand, G. L. Darlea, B. M. Waugh, Laura Gonella, Alan Poppleton, P. Chang, K. Ellis, V. Solovyev, D. Axen, A. E. Nuncio-Quiroz, D. Tardif, D. Kuhn, Chris Hays, D. M. Seliverstov, Marina Cobal, I. M. Gregor, Jiri Masik, Lawrence Lee, H. Merritt, P. Buchholz, Olivier Arnaez, Tim Martin, H. Fox, D. Hellmich, Tae Min Hong, H. Peng, Ossama AbouZeid, A. Quadt, M. Limper, A. R. Davison, D. Pelikan, Oleg Bulekov, D. Lissauer, A. La Rosa, A. Tonoyan, P. Sinervo, Y. Kulchitsky, T. C. Rave, F. Dydak, E. Lund, J. Schwindling, Stephen Watts, Franz E. Bauer, J. Farley, B. Kaplan, F. Tarrade, Valerio Bortolotto, S. Pataraia, Evgeniy Khramov, F. Derue, S. Gozpinar, Benedetto Gorini, David Lynn, C. Maiani, Sebastien Binet, Christoph Amelung, G. Watts, O. Brandt, Paolo Iengo, Helio Takai, Jun Wakabayashi, Vladimir Sulin, A. Meade, Christopher Bee, Stefano Veneziano, M. P. Giordani, I. N. Potrap, Harinder Singh Bawa, C. Hensel, K. Gellerstedt, S. Owen, B. Chapleau, D. Banfi, Didier Ferrere, Odette Benary, Marcus Morgenstern, Mihai Caprini, Trisha Farooque, Tobias Kruker, M. Gouighri, D. Iliadis, Philippe Calfayan, F. E. Taylor, S. A. Cetin, Theodoros Alexopoulos, Martin Tripiana, M. Sosebee, A. Roe, A. Ferrer, E. Romero Adam, H. Garitaonandia, F. G. Oakham, G. Negri, R. M. Jungst, Alessandra Forti, J. Fuster, A. Seiden, P. Loch, Rosemarie Aben, A. Kupco, S. Martin-Haugh, Naoki Kimura, A. E. Kiryunin, Paolo Francavilla, Andreas W. W. Ludwig, F. Luehring, B. H. Smart, M. Tatarkhanov, S. Swedish, T. Wang, A. Gemmell, Tord Ekelof, K. Leonhardt, J. Sodomka, L. Masetti, Y. Tayalati, Y. F. Ryabov, X. Espinal Curull, E. L. Barberio, Doris Chromek-Burckhart, C. Heller, Maria Rescigno, M. J. Shochet, Alexandre Rozanov, Claudio Santoni, J. A. Strong, I. Wilhelm, A. Lipniacka, Georges Aad, J. Zhong, J. Katzy, Francesco Ragusa, A. Chilingarov, M. Flechl, Hiroshi Sakamoto, C. Santamarina Rios, J. Bouchami, R. Dhullipudi, L. Nodulman, D. Derendarz, Yona Oren, Benedetto Giacobbe, J. Qian, J. Ginzburg, Reisaburo Tanaka, Livio Mapelli, Guido Volpi, N. Davidson, B. Dechenaux, Dilip Jana, S. Poddar, S. Spagnolo, R. J. Sobie, R. Konoplich, F. Tian, G. Avolio, A. Di Girolamo, P. Stavina, Jochen Dingfelder, Paolo Morettini, J. A. Mcfayden, E. Cheu, J. Z. Will, J. Antos, M. A. Parker, G. Azuelos, A. Rose, Serhat Istin, P. Strachota, R. Moles-Valls, Elvira Rossi, Joost Vossebeld, M. Turala, F. Fassi, R. Caminal Armadans, Luc Goossens, Matthias Wittgen, A. Blondel, Stefanos Leontsinis, M. Holder, V. Sopko, D. Harper, A. Succurro, Elliot Lipeles, L. Bugge, J. E. Brau, H. Ghazlane, Till Eifert, J. R. Batley, Brian Petersen, T. Delemontex, Brian Walsh, George Redlinger, E. Ptacek, D. Hayden, Ehud Duchovni, R. Stroynowski, R. Froeschl, G. Eigen, J. Walder, T. Spreitzer, P. Grafström, M. Pohl, M. I. Pedraza Morales, Vakhtang Tsulaia, Attilio Picazio, Thorsten Wengler, M. Klemetti, Murdock Gilchriese, Ph. Schwemling, Caterina Doglioni, Stanislav Tokár, M. Jimenez Belenguer, Will Davey, R. Pezoa, I. Satsounkevitch, A. Pacheco Pages, S. Klous, M. Legendre, E. Auge, Konstantin Belotskiy, J. Mamuzic, G. Lehmann Miotto, M. Teixeira Dias Castanheira, R. D. Kass, M. Smizanska, Pa. Malecki, C. Collins-Tooth, W. G. Scott, M. Mosidze, E. Cogneras, Ph. Schune, Claudio Luci, I. Dolenc, D. Short, B. Laforge, N. Sasao, M. S. Neubauer, Leszek Adamczyk, Andrea Sansoni, J. Poll, T. Burgess, Giuseppe Costa, P. Sherwood, M. Simonyan, J. Labbe, Matthias Klein, R. Giordano, Claudia Gemme, Michel Janus, Katsuo Tokushuku, A. J. Armbruster, T. Jakoubek, Yasuo Doi, Francis Anghinolfi, Monika Wielers, M. Tyndel, Simonetta Gentile, J. Moss, Andreas Battaglia, Vincent Garonne, Jun Guo, Osamu Sasaki, S. George, R. Camacho Toro, C. Bacci, H. Kroha, Adrian Chitan, Sandro Palestini, Frank Fiedler, Giovanni Maccarrone, Francois Touchard, J. Olszowska, R. K. Daya-Ishmukhametova, Itsuo Nakano, V. Ferrara, A. Macchiolo, Roberto Beccherle, M. Vos, V. Kouskoura, T. Davidek, B. Bittner, E. Torró Pastor, T. C. Meyer, S. Koenig, Giuseppe Iacobucci, Benjamin Trocmé, L. Labarga, Alison Lister, G. Cortiana, N. Ghodbane, S. Kluth, X. Ruan, J. Erdmann, K. Hamano, Michael Ernst, Raphael Vuillermet, Dusan Bruncko, M. Beimforde, M. Plamondon, Eric Lancon, D. Guest, S. Menke, Elena Plotnikova, Giorgi Arabidze, D. Sherman, J. Machado Miguens, J. Koll, M. Schram, Claire Malone, L. Y. Shan, A. De Salvo, Koji Terashi, T. P. A. Åkesson, J. Schovancova, T. Koffas, P. F. Klok, Shinichi Shimizu, Martine Bosman, G. G.G. Massaro, Sergio Gonzalez-Sevilla, J. Lundquist, Djamel Eddine Boumediene, Noam Hod, Anthony Keith Morley, Peter Wagner, F. Ahles, Manoj Jha, Jozsef Toth, V. J. Martin, Fairouz Malek, M. L. Andrieux, E. Kajomovitz, A. E. Barton, Kristin Lohwasser, T. Vazquez Schroeder, Cesare Bini, Laurent Vacavant, A. G. Goussiou, B. Lemmer, J. Haller, M. I. Gostkin, B. Maček, J. L. Pinfold, Giacinto Piacquadio, R. Van Der Leeuw, M. Düren, Giancarlo Spigo, S. P. Mc Kee, F. Bellina, Manuela Campanelli, M. Cascella, W. K. Brooks, S. Monzani, W. H. Bell, L. Tremblet, Nicolas Morange, M. Tsiakiris, C. M. Cuciuc, Michael Begel, L. Heelan, G. Sellers, N. M. Bolnet, Marcella Bona, J. Dolejsi, L. Di Ciaccio, Y. Fang, D. Lacour, Y. Yamazaki, B. Vachon, Stephen Hillier, A. Di Mattia, Luis Hervas, N. Möser, K. Dindar Yagci, R. R. Rios, Alexey Talyshev, D. Whittington, A. DellʼAcqua, Pamela Ferrari, D. C. Bailey, G. Anders, A. Antonaki, A. Belloni, C. Wasicki, Marco Bruschi, Paul Tipton, H. Torres, Daniel Silverstein, R. de Asmundis, K. Mönig, David Francis, M. Dobbs, Marcello Fanti, T. Hayakawa, Oleg Zenin, J. A. Parsons, Stefan Koperny, Julie Kirk, Sebastian Grinstein, S. Franchino, Wolfgang Mader, Goetz Gaycken, Ana Ovcharova, O. Silbert, James Catmore, K. Randrianarivony, B. Di Girolamo, Ashfaq Ahmad, D. A. Scannicchio, I. Fleck, P. Sicho, Jessica Metcalfe, S. Tarem, B. Sellden, R. Caputo, Roberto Spighi, S. Aoun, D. Smith, Sylvain Tisserant, E. Vinek, C. Le Maner, D. Hirschbuehl, S. Harkusha, Carlos Escobar, H. Sandaker, Craig Buttar, M. Trzebinski, Michael Dührssen, C. Lacasta, Mark Slater, Yoshiji Yasu, A. Andreazza, E. Piccaro, B. Brelier, M. A. Shupe, R. Yoshida, R. Bernhard, Kazuhiko Hara, V. P. Lombardo, J. Coggeshall, M. J. Tibbetts, G. Chiodini, C. Oropeza Barrera, X. C. Lou, M. Stanescu-Bellu, Aaron Bundock, K. Jon-And, D.C. OʼNeil, Daniel Froidevaux, A. Engl, T. Frank, Nathalie Besson, H. G. Moser, L. DellʼAsta, K. Nikolics, M. Bindi, J. Pina, G. Vegni, S. Vahsen, Masahiro Ikeno, C. M. Hernandez, T. Greenshaw, P. Kodys, P. Banerjee, T. Ohshima, Z. Hubacek, R. Kwee, A. Bangert, C. Schmitt, Erez Etzion, M. Werner, K. Gregersen, Elias Coniavitis, K. Mueller, D. A. Soh, Max Baak, G. Sedov, G. Blanchot, Laurent Serin, W. Edson, P. van Gemmeren, R. van der Geer, M. Nagel, Georgios Iakovidis, M. A.L. Leite, L. March, Zvi Hirsh Citron, E. Shabalina, Z. Dolezal, L. Asquith, Paul Laycock, T. J. Khoo, T. Blazek, Emmanuel Sauvan, J. Bohm, S. M. Consonni, E. J. Feng, S. Ferrag, Francois Vazeille, David Calvet, K. H. Becks, L. Nozka, B. Lundberg, Karlheinz Meier, Dieter H. H. Hoffmann, C. Handel, J. Almond, A. Washbrook, K. W. Wozniak, R. T. Chislett, Shingo Kazama, O. Cakir, B. Brau, F. Niedercorn, J. Glatzer, P. Farthouat, R. Ciftci, V. P. Maleev, Bruce Barnett, E. Rizvi, S. Baker, M. G. Vincter, Eduard Simioni, C. Liu, C. Caso, M. Yilmaz, K. J. Grahn, Reinhard Schwienhorst, M. Tasevsky, Dave Charlton, A. Bruni, Aliaksandr Pranko, J. Poveda, F. Lo Sterzo, Corinne Goy, Karl Jakobs, James Boyd, S. P. Ahlen, R. Leitner, Y. Sugaya, J. A. Manjarres Ramos, R. Sandstroem, O. Stelzer-Chilton, M. C. Stockton, A. 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Uslenghi, Tim Jones, Giuseppe Mornacchi, S. L. Lloyd, L. Kashif, Tadeusz Kowalski, S. E. Allwood-Spiers, D.C. Rahm, Deepak Kar, Nikolina Ilic, Fabrizio Petrucci, H. Liu, Fr Pastore, Jeanette Lorenz, A. Dotti, Kevin Einsweiler, James M. Buchanan, J. B. Blanchard, H. M. Braun, Ikuo Ueda, K. Amako, M. Svatos, S. Mitsui, J. Meyer, A. Juste Rozas, E. Fullana Torregrosa, L. Bellagamba, N. van Eldik, N. Barlow, H. F.W. Sadrozinski, S. Malyukov, M. P. Goulette, J. R. Hansen, F. Lepold, E. Arik, Olga Igonkina, J. Deng, Nikos Giokaris, J. D. Palmer, Albert Olariu, Mikhail Demichev, Milind Purohit, M. Beckingham, P. Fleischmann, Ping-Kun Teng, A. Pinder, L. Duguid, J. Snow, E. Valladolid Gallego, C. Geweniger, W. M. Thong, A. Dafinca, A. Do Valle Wemans, I. Orlov, J. Beringer, G. Alexandre, P. Nilsson, Edith Knoops, R. Klingenberg, Fedor Prokoshin, Pierre Savard, Alastair Dewhurst, Heinz Pernegger, Kilian Rosbach, Alexander Oh, G. Kramberger, N. Grigalashvili, H. Nilsen, P. 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Maidantchik, Georgios Tsipolitis, Rinat Fakhrutdinov, Ariel Schwartzman, T. Sumida, Y. A. Kurochkin, D. Ludwig, C. J. Oram, T. Shin, A. Filipčič, Eugene E. Schmidt, Nansi Andari, S. Tanaka, Timothy Andeen, V. OʼShea, Andrey Soukharev, J. Wetter, R. Van Berg, Jieh-Wen Tsung, Alessandro Cerri, Philip Bechtle, Lea Caminada, A. C. König, D. Joffe, Frank Ellinghaus, Giovanni Crosetti, Claire Gwenlan, P. V. Tsiareshka, Catrin Bernius, J. Krstic, S. Kohlmann, J. S. Keller, R. K. Keeler, Y. Jiang, Stefan Simion, I. Torchiani, P. Steinbach, T. Harenberg, Philip Phillips, A. F. Saavedra, S. J. Sekula, Jochen Schieck, M. Dam, S. Guindon, J. Ludwig, S. O. Holmgren, Mihail Chizhov, E. Pueschel, Marina Rotaru, N. Dressnandt, H. van der Graaf, Stephen Maxfield, Bruno Mansoulie, Paul Newman, S. Hillert, E. I. Rosenberg, M. El Kacimi, D. Petschull, C. Deluca, H. S. Lee, Francesco Lanni, D. Y. Bardin, G. M. Kolachev, S. Timoshenko, R. Seuster, Ilya Korolkov, J. Penwell, M. C. Conidi, Zhiqing Zhang, J. Mitrevski, Alexei Klimentov, G. A. Rosenbaum, J. P. Ottersbach, T. Fonseca Martin, Helena Santos, W. B. Quayle, M. Schwoerer, Xin Wu, M. Agustoni, Abdenour Lounis, Basil Schneider, R. Mehdiyev, Antonio Sidoti, Ian Hinchliffe, J. Searcy, Patrick Czodrowski, R. Calkins, P. Matricon, Shikma Bressler, Iacopo Vivarelli, T. T. Voss, J. Purdham, R. S. B. King, S. Fleischmann, S. Campana, U. Mallik, S. C. Lee, Moritz Backes, S. DʼAuria, M. Tylmad, F. Rühr, V. Juranek, A. Trzupek, A. S. Randle-Conde, T. Theveneaux-Pelzer, J. Miao, L. Magnoni, Takahiko Kondo, M. Ridel, K. Augsten, Klaus Kurt Desch, Richard Nickerson, Y. Davygora, S. Marti-Garcia, Pai-hsien Jennifer Hsu, A. Taffard, Nazim Huseynov, V. I. Kolesnikov, Petre Dita, R. M. Neves, P. Haefner, Halina Bilokon, J. D. Price, S. Youssef, D. Ventura, X. Chen, S. Walch, T. Colombo, Evelyn Thomson, G. Palacino, J. J. Goodson, B. R. Ko, M. Aharrouche, Johannes Elmsheuser, G. Gagliardi, A. Polini, J. Goncalves Pinto Firmino Da Costa, Sergey Peleganchuk, Gaetano Barone, V. Boldea, T. Rador, J. P. Martin, Sarah Demers, Francisco Alonso, Arnaud Lucotte, Liza Mijović, B. DeWilde, M. Leyton, Andrew Mehta, Rosy Nicolaidou, M. I. Besana, Y. B. Pan, H. Boterenbrood, C. W. Loh, Dave Britton, J. E. Derkaoui, M. Myska, Alexander Khodinov, Matteo Negrini, D. De Pedis, V. Rossetti, Iwona Grabowska-Bold, G. Khoriauli, T. Lari, J. A. Benitez Garcia, S. Caughron, Michael Rijssenbeek, W. C. Wong, C. Fabre, E. Laisne, António Amorim, Laurent Duflot, R. Wall, M. Karagounis, K. J.C. Leney, T. Barber, G. Hughes, K. H. Hiller, D. Lopez Mateos, Tetsuro Mashimo, M. Kuna, M. Fraternali, A. Zoccoli, B. Martin, D. Schouten, V. Kartvelishvili, Shota Tsiskaridze, B. M. Salvachua Ferrando, M. Solar, M. A. Chelstowska, Diedi Hu, T. Moa, S. Haider, A. Chafaq, Vincenzo Canale, C. Debenedetti, J. Nadal, J. Sjölin, T. Dai, J. Cantero, S. Kalinin, David-leon Pohl, J. Kaplon, M. Suk, Rustem Ospanov, Claire Bourdarios, Sergey Panitkin, Todd Brian Huffman, Anna Mastroberardino, M. A. B. do Vale, Uta Klein, J. D. Chapman, Jiangyong Jia, B. Stugu, V. A. Mitsou, T. Kohriki, A. Antonov, F. Krejci, Helen Hayward, Takashi Yamanaka, P. M. Watkins, H. G. Sander, C. N. Booth, Richard Mount, V. Scharf, Joshua Kunkle, R. Wang, V. Chavda, Shaun Roe, M. Oliveira, Veysi Erkcan Ozcan, Vincenzo Izzo, N. Rompotis, Samuel Calvet, A. Vaniachine, N. C. Edwards, P. D. Thompson, J. Barreiro Guimarães da Costa, S. Kaneti, H. Brown, M. J. White, Benedict Allbrooke, Saminder Dhaliwal, G. Akimoto, Riccardo-Maria Bianchi, Joseph Izen, D. Zhang, J-P. Meyer, M. Mikestikova, D. Arutinov, Y. Wu, W. Lukas, Y. Bai, Michel Lefebvre, M. J. Fisher, M. Pecsy, D. Benchekroun, Louis Helary, B. Pinto, C. Glasman, P. Giovannini, M. S. Kayl, D. Zieminska, Andrew Pilkington, A. R. Gillman, B.J. OʼBrien, Bobby Samir Acharya, Bruno Lenzi, Carla Sbarra, A. White, O. Gutzwiller, D. Price, Ph. Schwegler, N. Orlando, Guillaume Unal, J. T. Linnemann, Daniela Salvatore, E. B. Diehl, D. Vladoiu, Ruslan Mashinistov, Quentin Buat, Alessandra Ciocio, K. Sliwa, D. R. Quarrie, L. Han, Prolay Mal, Tomiyoshi Haruyama, V. Lendermann, W. L. Ebenstein, Gabriella Pasztor, M. Hirose, Michel Raymond, T. A. Dietzsch, J. Dubbert, Leonardo Merola, P. Starovoitov, A. M. Litke, P. U. E. Onyisi, David Yu, S. Michal, E. Banas, T. Zhao, John Stupak, Evgeny Starchenko, C. Padilla Aranda, D. Sampsonidis, Timothy Brooks, Arturo Sanchez, T. Jovin, Kenneth Wraight, P. K. Behera, M. Perantoni, C. De La Taille, Peter Wienemann, N. Krumnack, Javier Sánchez, A. Mayne, D. Hall, H. Li, S. M. Piec, Nicole Ruckstuhl, Michael Hance, Evgeny Shulga, A. J. Barr, R. R. Debbe, Thi Kieu Oanh Doan, H. Wang, G. Cattani, H. Takeda, Antonio Ereditato, Igor Aleksandrov, L. Micu, S. Yacoob, K. W. Glitza, Halina Abramowicz, D. Levin, S. Caron, S. Yu. Smirnov, J. Gunther, M. Ugland, M. J. Losty, A. De Santo, Liron Barak, C. Taylor, Alexander Undrus, Konstantinos Karakostas, Lorenzo Feligioni, V. A. Giakoumopoulou, Irinel Caprini, Z. Kohout, Tatsuya Masubuchi, Oliver Keith Baker, W. S. Lockman, Daniel Whiteson, H. Kurashige, S. Laplace, C. Dallapiccola, M. Vlasak, Dmitri Tsybychev, R. L. McCarthy, O. Røhne, E. Torrence, Bradley Cox, Vladimir Peshekhonov, S. Johnert, C. Schiavi, S. Aefsky, John Alison, D. della Volpe, M. Moreno Llácer, M. Kurata, C. Pahl, M. C. N. Fiolhais, Frank Winklmeier, F. Bucci, Z. Zinonos, M. Lehmacher, R. Caloi, Umar Gul, M. A. Alam, J. A. Klinger, A. M. Rahimi, M. Ibbotson, Christine Kourkoumelis, M. Rybar, D. Barberis, Pedro Jorge, Sarah Heim, Mauro Iodice, S. V. Mouraviev, C. Bohm, V. Grassi, Monica Dunford, Ch Geich-Gimbel, S. Bedikian, Andreas Salzburger, J. Maneira, P. Loscutoff, J. Virzi, Ruggero Turra, F. Corriveau, B. Martin dit Latour, D. Boscherini, Woiciech Fedorko, Dorothee Schaile, Claudia Bertella, Michael Boehler, Metin Arik, F. Safai Tehrani, S. Pospisil, V. O. Tikhomirov, M. Davies, Alexey Anisenkov, T. Nunnemann, K. Edmonds, G. Duckeck, B. Aubert, A. Mengarelli, Ian Brock, R. Di Nardo, P. Hodgson, E. V. Bouhova-Thacker, V. Andrei, Federica Legger, Clara Troncon, R. Kowalewski, F. Wicek, Lukasz Zwalinski, I. Stumer, T. Hrynʼova, G. W. Brandenburg, Masaharu Nomachi, Christoph Rembser, J. Mc Donald, L. Chikovani, A. A. Minaenko, Agnieszka Leyko, E. Badescu, F. Friedrich, A. Rimoldi, Bartosz Mindur, Antonio Baroncelli, Ulrich Landgraf, L. de Mora, H. Yamaguchi, F. Cerutti, D. Errede, M. Franchini, G. Nunes Hanninger, M. J. Costa, A. Tykhonov, J. Petersen, N. Vranjes, K. M. Mercurio, S. Nektarijevic, M. Morii, Ryo Nagai, F. Ould-Saada, B. Guo, Valerio Dao, B. G. Fulsom, Holger Schulz, M. Medinnis, T. Kubota, C. Pizio, Yang Gao, A. Ruiz-Martinez, M. Uhlenbrock, Y. V. Grishkevich, Andrea Favareto, Enrico Tassi, F. Salvatore, H. Liao, Scarlet Norberg, J. G. Rocha de Lima, V. A. Schegelsky, R. Di Sipio, D. H. Saxon, J. R. Goddard, J. Kvita, I. M. Trigger, N. I. Zimin, M. Hohlfeld, X. Portell Bueso, L. De Nooij, A. S. Kozhin, A. J. Lowe, T. G. McCarthy, Ralf Hertenberger, D. Côté, Irakli Minashvili, A. A. Abdelalim, V. Giangiobbe, M. L. Gonzalez Silva, D. Gillberg, X. Ju, M. Kuze, Y. Azuma, Frank Paige, Else Lytken, S. Goldfarb, F. Broggi, T. Mclaughlan, D. Xu, Amanda R. Vest, Speranza Falciano, G. D. Carrillo-Montoya, P. Bernat, E. van der Poel, E. Gorini, Uladzimir Kruchonak, Gideon Alexander, Cristian Stanescu, P. J. Bell, P. Branchini, Sw. Banerjee, Mikhail Mineev, Ovsat Abdinov, C. Fukunaga, V. Kaushik, M. Ishitsuka, A. Manousakis-Katsikakis, A. Staude, Danuta Kisielewska, Allan G Clark, Roger Moore, N. Zhou, S. González de la Hoz, B. Yabsley, K. Hanawa, Kirika Uchida, Tatsumi Koi, S. Yamamoto, Sabine Crépé-Renaudin, P. Waller, L. Živković, Emmanuel Busato, T. Buanes, P. Klimek, C. Roda, J. Valenta, A. Bogouch, S. Mättig, Valerie Susanne Lang, T. Varol, Fred Hartjes, J. Wotschack, B. Fatholahzadeh, Hans Krüger, U. Soldevila, Howard Gordon, K. E. Selbach, Yosuke Takubo, David Berge, J. A. Aguilar-Saavedra, M. Cirilli, Z. L. Ren, C. A. Jung, Michela Biglietti, Miroslav Havranek, Fabienne Ledroit-Guillon, Vadim Kantserov, C. Cowden, V. Zutshi, L. S. Gomez Fajardo, H. Czirr, J. F. Marchand, M. Mazur, D. Wendland, Massimiliano Bellomo, S. De Castro, Y. Rozen, H-C. Schultz-Coulon, Nicola Venturi, Sergey Burdin, Dmitry Emeliyanov, J. C. Clemens, Yasuhiro Makida, V. Radescu, Steve McMahon, Robert Gardner, Stefan Schlenker, C. Isaksson, R. Ueno, T. Naumann, Margret Fincke-Keeler, R. P. Thun, S. P. Denisov, S. Oda, C. P. Ward, M. A. Thomson, M. Henke, A. Brandt, M. Giunta, M. C. Vetterli, Martin Spousta, I. J. Watson, B. Resende, S. P. Bieniek, Iftach Sadeh, Giacomo Polesello, D. Tsionou, M. Y. Kazarinov, P. A. Gorbounov, M. Livan, T. Kluge, A. L. Read, F. Grancagnolo, Christoph Falk Anders, M. S. Alam, Martin Kocian, M. Nash, Giuseppe Francesco Tartarelli, J. Llorente Merino, S. P. Amor Dos Santos, M. Karnevskiy, V. Consorti, Cedric Serfon, Florencia Canelli, Dirk Zerwas, S. Pashapour, Aleandro Nisati, Beate Heinemann, I. Dawson, B. Lund-Jensen, K. Stoerig, E. K. U. Gross, U. De Sanctis, T. Slavicek, Göran Jarlskog, M. Fehling-Kaschek, L. A. Kogan, S. Xella, J. Griffiths, Valentina Tudorache, S. F. Brazzale, F. Barreiro, A. Gomes, Kirsten Tollefson, M. Mikuž, K. E. Johansson, R. E. Blair, A. Dos Anjos, J. Ernwein, M. Battistin, Yousuke Kataoka, O. E. Vickey Boeriu, L. M. Mir, D. Goujdami, M. D. M. Capeans Garrido, P. Koevesarki, T. Beau, S. Pedraza Lopez, Marc Escalier, F. Podlyski, P. Schacht, G. E. Pospelov, W. Fernando, S. Franz, H. Duran Yildiz, Z. V. Krumshteyn, Kohei Yorita, P. Ruzicka, A. Bertin, Andree Robichaud-Veronneau, T. Sarangi, V. V. Zmouchko, Alfred Goshaw, Francesco Michelangelo Giorgi, L. Rinaldi, K. Tackmann, E. Sarkisyan-Grinbaum, E. Reinherz-Aronis, Federico Meloni, G. Colon, Andrea Catinaccio, W. Buttinger, A. G. Myagkov, B. H. Samset, J. A. Bogaerts, Timothy Barklow, J. Salt, N. Krieger, E. Oliver Garcia, Renat Sadykov, Rudiger Voss, Louise Skinnari, J. Love, S. Chen, K. Grybel, Akira Yamamoto, S. Thoma, I. Reisinger, H. Ten Kate, J. Ye, Simona Serena Bocchetta, J. E.M. Robinson, T. Ženiš, J. Rothberg, F. M. Newcomer, G. Chiefari, V. Castillo Gimenez, David Salek, Francesco Spanò, D. Robinson, S. Kreiss, U. Bratzler, O. M. Kind, A. Poblaguev, Giuseppe Salamanna, K. J. Anderson, L. Hooft van Huysduynen, Zuzana Rurikova, Alexander Bogdanchikov, T. Abajyan, M. Sandhoff, Anne Kathrin Becker, J. Solc, Takuya Nobe, S. Strandberg, R. Mameghani, O. Le Dortz, L. L. Ma, W. Mohr, J. B. De Vivie De Regie, Jan Kretzschmar, D. S. Damiani, K. Prokofiev, D. Wicke, A. Warburton, Eleni Mountricha, T. Barillari, Grigori Rybkin, B. Gaur, V. Nguyen Thi Hong, Carolina Gabaldon, O. M. Harris, R. Mackeprang, A. Harvey, V. Bansal, M. Johansen, S. W. Snow, E. Davies, J. de Graat, G. Mirabelli, Henso Abreu, A. S. Cerqueira, R. E. Long, S. Horner, M. Bianco, N. Soni, R. J. Hawkings, A. Hoummada, Lj. Simic, A. Hamilton, A. Shibata, T. Kittelmann, William Trischuk, A. Passeri, T. Djobava, Oxana Smirnova, T. Todorov, A. Renaud, Konstantinos Bachas, P. Giusti, R. D. Schamberger, Malte Backhaus, Pascal Pralavorio, Lamberto Luminari, Dong Su, I. Vichou, S. Rolli, R. Zaidan, M. Fiascaris, J. A. Frost, Kristian Peters, K. Lie, Gabriella Sciolla, Y. Munwes, G. Fischer, Louis Fayard, K. Perez, G. Zobernig, L. A. Thomsen, G. Unel, P. Lichard, C. P. Marino, F. Marchese, Valery Pozdnyakov, V. Gratchev, Jean-Francois Laporte, J. Lundberg, E. Carquin, C. Schroeder, Fabrice Hubaut, P. Pais, C. G. Lester, S. Kuleshov, Kazunori Hanagaki, G. Nanava, K. Kiuchi, L. Fabbri, C. A. Solans, Marcello Borri, Charles Leggett, Fabian Huegging, A. M. Zaitsev, M. Mazzanti, A. A. Carter, M. Miñano Moya, Giacomo Artoni, R. C.W. Henderson, V. I. Rud, James Howarth, S. Sultansoy, V. Zhuravlov, Stephen Haywood, Sotirios Vlachos, A. Redelbach, David Miller, A. Ochi, Vladimir Vinogradov, W. Iwanski, Gabriel Stoicea, R. Staszewski, Marcella Capua, Alessandra Doria, and E. Chareyre

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Muon, Large Hadron Collider, 010308 nuclear & particles physics, Atlas detector, Astrophysics::High Energy Astrophysical Phenomena, 01 natural sciences, Collimated light, Nuclear physics, Massless particle, Hidden sector, 0103 physical sciences, Higgs boson, Physics::Accelerator Physics, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics, Lepton
Abstract

A search is performed for collimated muon pairs displaced from the primary vertex produced in the decay of long-lived neutral particles in proton-proton collisions at root s = 7 TeV centre-of-mass ...

Published
2013
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32. Bayesian comparison of voice coil impedance models for dynamic loudspeakers

Author

R. Wesley Henderson and Paul M. Goggans

Subjects
Inductance, Engineering, business.industry, Bayesian probability, Electronic engineering, Voice coil, Loudspeaker, Lossy compression, Bayesian inference, business, Electrical impedance, Nested sampling algorithm
Abstract

Loudspeaker design requires accurate models of driver voice coil impedance. This paper examines three model classes (standard, Leach, and van Maanen) from the audio literature and compares them using Bayesian model comparison via nested sampling. Data is generated from impedance measurements of two commercial loudspeaker drivers. We conclude that, for most design tasks involving these drivers, the van Maanen model with 3 lossy inductance groups is the most appropriate model.

Published
2017
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33. Cartilage-like electrostatic stiffening of responsive cryogel scaffolds

Author

G S, Offeddu, I, Mela, P, Jeggle, R M, Henderson, S K, Smoukov, and M L, Oyen

Subjects
Cartilage, Articular, Microscopy, Confocal, Compressive Strength, Static Electricity, technology, industry, and agriculture, Acrylic Resins, Temperature, Hydrogels, Hydrogen-Ion Concentration, Microscopy, Atomic Force, Polyelectrolytes, Permeability, Article, Elastic Modulus, Polyvinyl Alcohol, Porosity, Cryogels
Abstract

Cartilage is a structural tissue with unique mechanical properties deriving from its electrically-charged porous structure. Traditional three-dimensional environments for the culture of cells fail to display the complex physical response displayed by the natural tissue. In this work, the reproduction of the charged environment found in cartilage is achieved using polyelectrolyte hydrogels based on polyvinyl alcohol and polyacrylic acid. The mechanical response and morphology of microporous physically-crosslinked cryogels are compared to those of heat-treated chemical gels made from the same polymers, as a result of pH-dependent swelling. In contrast to the heat-treated chemically-crosslinked gels, the elastic modulus of the physical cryogels was found to increase with charge activation and swelling, explained by the occurrence of electrostatic stiffening of the polymer chains at large charge densities. At the same time, the permeability of both materials to fluid flow was impaired by the presence of electric charges. This cartilage-like mechanical behavior displayed by responsive cryogels can be reproduced in other polyelectrolyte hydrogel systems to fabricate biomimetic cellular scaffolds for the repair of the tissue.

Published
2016

34. Square dielectric THz waveguides

Author

N. Aflakian, N. Yang, T. LaFave, R. M. Henderson, K. K. O, and D. L. MacFarlane

Subjects
Mode scrambler, Mode volume, Materials science, business.industry, Single-mode optical fiber, Physics::Optics, 02 engineering and technology, 021001 nanoscience & nanotechnology, Cladding (fiber optics), 01 natural sciences, Atomic and Molecular Physics, and Optics, law.invention, Transverse mode, 010309 optics, Mode field diameter, Optics, law, 0103 physical sciences, Radiation mode, 0210 nano-technology, business, Waveguide
Abstract

A holey cladding dielectric waveguide with square cross section is designed, simulated, fabricated and characterized. The TOPAS waveguide is designed to be single mode across the broad frequency range of 180 GHz to 360 GHz as shown by finite-difference time domain simulation and to robustly support simultaneous TE and TM mode propagation. The square fiber geometry is realized by pulling through a heat distribution made square by appropriate furnace design. The transmitted mode profile is imaged using a vector network analyzer with a pinhole at the receiver module. Good agreement between the measured mode distribution and the calculated mode distribution is demonstrated.

Published
2016

35. Barriers to shared decision making in mental health care: qualitative study of the Joint Crisis Plan for psychosis

Author

R. Claire Henderson, Diana Rose, Helen Lester, Max Birchwood, Matthew Marshall, George Szmukler, Simone Farrelly, Waquas Waheed, and Graham Thornicroft

Subjects
Adult, Male, Mental Health Services, Decision Making, Psychological intervention, Patient Care Planning, State Medicine, Grounded theory, 03 medical and health sciences, 0302 clinical medicine, Nursing, Intervention (counseling), Humans, Medicine, Care Programme Approach, Crisis plan, 030212 general & internal medicine, Shared decision making, Qualitative Research, Physician-Patient Relations, business.industry, Public Health, Environmental and Occupational Health, Patient Preference, Focus Groups, Middle Aged, Psychosis, Focus group, Mental health, 3. Good health, 030227 psychiatry, England, Psychotic Disorders, Care programme approach, Grounded Theory, Female, Patient Participation, business, RA, Original Research Papers, RC, Social context, Qualitative research
Abstract

BACKGROUND:Despite increasing calls for shared decision making (SDM), the precise mechanisms for its attainment are unclear. Sharing decisions in mental health care may be especially complex. Fluctuations in service user capacity and significant power differences are particular barriers.OBJECTIVE AND DESIGN:We trialled a form of facilitated SDM that aimed to generate patients' treatment preferences in advance of a possible relapse. The 'Joint Crisis Plan' (JCP) intervention was trialled in four mental health trusts in England between 2008 and 2011. This qualitative study used grounded theory methods to analyse focus group and interview data to understand how stakeholders perceived the intervention and the barriers to SDM in the form of a JCP.RESULTS:Fifty service users with psychotic disorders and 45 clinicians participated in focus groups or interviews between February 2010 and November 2011. Results suggested four barriers to clinician engagement in the JCP: (i) ambivalence about care planning; (ii) perceptions that they were 'already doing SDM'; (iii) concerns regarding the clinical 'appropriateness of service users' choices'; and (iv) limited 'availability of service users' choices'. Service users reported barriers to SDM in routine practice, most of which were addressed by the JCP process. Barriers identified by clinicians led to their lack of constructive engagement in the process, undermining the service users' experience.CONCLUSIONS:Future work requires interventions targeted at the engagement of clinicians addressing their concerns about SDM. Particular strategies include organizational investment in implementation of service users' choices and directly training clinicians in SDM communication processes.

Published
2016
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36. Online Digital Data Processing for the T2K Fine Grained Detector

Author

H. Tanaka, N. Braam, S. M. Oser, C. Gutjahr, J. Zalipska, A. Miller, P-A Amaudruz, K. Olchanski, K. Mizouchi, N. Honkanen, C. J. Pearson, R. Poutissou, D. Karlen, P. Poffenberger, R. S. Henderson, D. Bishop, C. Ohlmann, F. Retiere, T. Lindner, M. J. Wilking, B. Kirby, and R. Hasanen

Subjects
Nuclear and High Energy Physics, Engineering, business.industry, Detector, Front and back ends, Data acquisition, Nuclear Energy and Engineering, Application-specific integrated circuit, Nuclear electronics, Electronic engineering, Waveform, Electrical and Electronic Engineering, business, Field-programmable gate array, Zero suppression
Abstract

The T2K Fine Grained Detector (FGD) is an active neutrino target that uses segmented scintillator bars to observe short-range particle tracks. 8448 multipixel photon counters (MPPCs) coupled to wavelength shifting fibres detect scintillator light. An application specific integrated circuit (ASIC) shapes the MPPC waveform and uses a switched capacitor array (SCA) to store up to 511 analog samples over 10.22 μs. High and low attenuation channels for each MPPC improve dynamic range. 12-bit serial quad-ADCs digitize ASIC analog output and interface with a field programmable gate array (FPGA). Each FPGA simultaneously reads out four ADCs and saves the synchronized samples in an external digital memory. The system produces 13.5 MB of uncompressed data with a target trigger rate of 20 Hz, and requires zero suppression to reduce data size and readout time. Firmware based data compression uses an online pulse-finder that decides whether to output pulse height information, a section of waveform, or to suppress all data. The front end FPGA transfers formatted data to data concentrator cards (DCCs) through a 2 Gb/s optical fiber interface using an efficient custom protocol. We have evaluated the performance of the FGD electronics system and the quality of its online data compression through the course of a physics data run. The average size of a compressed data acquisition is measured as 44 ~ kB.

Published
2011
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38. Surfactant and irrigation effects on wettable soils: runoff, erosion, and water retention responses

Author

R. A. Henderson, Gary A. Lehrsch, J. L. Reed, S. J. Kostka, and Robert E. Sojka

Subjects
Field capacity, Infiltration (hydrology), Soil structure, Hydrophobic soil, Environmental chemistry, Soil water, Environmental science, Soil science, Surface runoff, Water content, Leaching model, Water Science and Technology
Abstract

Surfactants are chemical compounds that change the contact angle of water on solid surfaces and are commonly used to increase infiltration into hydrophobic soil. Since production fields with water-repellent soil often contain areas of wettable soil, surfactants applied to such fields will likely be applied to wettable soil, with unknown consequences for irrigation-induced erosion, runoff, or soil water relations. We evaluated surfactant and simulated sprinkler irrigation effects on these responses for three wettable, Pacific Northwest soils, Latahco and Rad silt loams and Quincy sandy loam. We studied three surfactants: an alkyl polyglycoside in solution at a concentration of 18 g a.i./kg, a block copolymer at 26 g/kg, and a blend of the two at 43 g/kg. From 2005 to 2009 in the laboratory, each surfactant was sprayed at a rate of 46.8 L/ha onto each soil packed by tamping into 1.2- by 1.5-m steel boxes. Thereafter, each treated soil was irrigated twice at 88 mm/h with surfactant–free, well water. Runoff and sediment loss were measured for each irrigation and soil samples were collected after each irrigation. While measured properties differed among soils and irrigations, surfactants had no effect on runoff, sediment loss, splash loss, time to runoff, or tension infiltration, compared to controls. Across all soils, however, the alkyl polyglycoside increased volumetric water contents by about 3% (significant at P less than or equal to 0.08) at matric potentials from 0 to -20 kPa, compared to controls. With a decrease in the liquid-solid contact angle on treated soil surfaces, surfactant–free water appeared able to enter, and be retained in pores with diameters greater than or equal to 15 mm. All in all, surfactants applied at economic rates to these wettable Pacific Northwest soils posed little risk of increasing either runoff or erosion or harming soil water relations. Moreover, by increasing water retention at high potentials, surfactants applied to wettable soils may allow water containing pesticides or other agricultural chemicals to better penetrate soil pores, thereby increasing the efficacy of the co-applied materials.

Published
2010
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39. A critical assessment of different transmethylation procedures commonly employed in the fatty acid analysis of aquatic organisms

Author

Christian Schlechtriem, R. James Henderson, and Douglas R. Tocher

Subjects
inorganic chemicals, chemistry.chemical_classification, Wax, Chromatography, Fatty acid, Ocean Engineering, Hydrochloric acid, Catalysis, chemistry.chemical_compound, chemistry, visual_art, Anhydrous, visual_art.visual_art_medium, Organic chemistry, Derivatization, Transmethylation, Boron trifluoride
Abstract

Several transmethylation procedures have been used for fatty acid analysis of aquatic organisms, although the suitability of the applied procedures has rarely been tested. The aim of this study was to demonstrate how different derivatization procedures can affect the result of fatty acid analysis. Different transmethylation procedures based on the acidic catalysts boron trifluoride, concentrated sulphuric acid, and anhydrous hydrochloric acid were applied to cold-pressed copepod oil and Atlantic salmon flesh lipids rich in wax esters and triacylglycerols, respectively. The results show that (1) the use of unsuitable catalysts and/or incubation conditions may influence the data obtained, which can lead to inaccurate conclusions about the presence of fatty acids in aquatic organisms/ecosystems, (2) different derivatization procedures based on the same catalyst can produce diverging results, and (3) the efficiency of a selected catalyst/procedure should be verified (e.g., by thin-layer chromatography) to ensure the complete transmethylation of fatty acids.

Published
2008
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40. Statistical properties of Pu 243 , and Pu 242 ( n , γ

Author

T. A. Laplace, F. Zeiser, M. Guttormsen, A. C. Larsen, D. L. Bleuel, L. A. Bernstein, B. L. Goldblum, S. Siem, F. L. Bello Garotte, J. A. Brown, L. Crespo Campo, T. K. Eriksen, F. Giacoppo, A. Görgen, K. Hadyńska-Klȩk, R. A. Henderson, M. Klintefjord, M. Lebois, T. Renstrøm, S. J. Rose, E. Sahin, T. G. Tornyi, G. M. Tveten, A. Voinov, M. Wiedeking, J. N. Wilson, and W. Younes

Published
2016
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42. Inherited PAX6, NF1 and OTX2 mutations in a child with microphthalmia and aniridia

Author

Sally Ann Lynch, R. Alex Henderson, Veronica van Heyningen, Isabel M. Hanson, Michael P. Clarke, Sanjay M. Sisodiya, David R. FitzPatrick, Kathy Williamson, and Sally Cumming

Subjects
Male, Proband, congenital, hereditary, and neonatal diseases and abnormalities, Microcephaly, PAX6 Transcription Factor, Nonsense mutation, Microphthalmia, Gene interaction, Café au lait spot, Genetics, Humans, Microphthalmos, Paired Box Transcription Factors, Medicine, Missense mutation, Eye Proteins, Aniridia, Genetics (clinical), Homeodomain Proteins, Neurofibromin 1, Otx Transcription Factors, business.industry, medicine.disease, eye diseases, Pedigree, Repressor Proteins, Amino Acid Substitution, Child, Preschool, Female, sense organs, medicine.symptom, business
Abstract

A girl with aniridia, microphthalmia, microcephaly and café au lait macules was found to have mutations in PAX6, NF1 and OTX2. A novel PAX6 missense mutation (p.R38W) was inherited from her mother whose iris phenotype had not been evident because of ocular neurofibromatosis. Analysis of the NF1 gene in the proband, prompted by the mother's diagnosis and the presence of café au lait spots, revealed a nonsense mutation (p.R192X). Subsequently an OTX2 nonsense mutation (p.Y179X) was identified and shown to be inherited from her father who was initially diagnosed with Leber's congenital amaurosis. Since individual mutations in PAX6, OTX2 or NF1 can cause a variety of severe developmental defects, the proband's phenotype is surprisingly mild. This case shows that patients with complex phenotypes should not be eliminated from subsequent mutation analysis after one or even two mutations are found.

Published
2007
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44. Distribution and new host records for Cosmospora aurantiicola and Cosmospora flammea entomopathogens of Diaspididae in New Zealand

Author

J. L. Tyson, K. J. Froud, R. A. Fullerton, L. E. Jamieson, and R. C. Henderson

Subjects
Aspidiotus nerii, biology, Host (biology), Biological pest control, Horticulture, Diaspididae, biology.organism_classification, Pinnaspis, Cosmospora aurantiicola, Insect Science, Botany, Eriococcidae, Cosmospora, Agronomy and Crop Science
Abstract

Adventive armoured scale insects (Diaspididae) are of particular concern in New Zealand horticulture due to their polyphagous nature, the damage they can cause, and their implications in biosecurity. Two important species of fungal entomopathogens recorded on armoured scale insects in New Zealand are Cosmospora aurantiicola (Fusarium larvarum) and C. fl ammea (F. coccophilum). Both have previously been recorded in New Zealand from unidentifi ed Coccoidea; C. aurantiicola has also been recorded on Hemiberlesia lataniae and H. rapax. During 2002–2003, fi ve forays were carried out to provide further information on the host range of the species and to collect strains of the entomopathogens that may have potential as biocontrol agents for armoured scale insects. Aspidiotus nerii, Hemiberlesia sp., Leucaspis brittini, Leucaspis spp., Pinnaspis dysoxyli and Eriococcus cavelli (Eriococcidae) were recorded as new host species for C.fl ammea. Hemiberlesia lataniae is reconfi rmed as a host for both species.

Published
2005
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45. Environmental and dietary influences on highly unsaturated fatty acid biosynthesis and expression of fatty acyl desaturase and elongase genes in liver of Atlantic salmon (Salmo salar)

Author

R. James Henderson, Douglas R. Tocher, Xiaozhong Zheng, James R. Dick, J. Gordon Bell, and Bente E. Torstensen

Subjects
Fatty Acid Desaturases, Fatty Acid Elongases, Salmo salar, Environment, Dietary Fats, Unsaturated, Aquaculture, Acetyltransferases, Animals, Plant Oils, Seawater, Salmo, Molecular Biology, Unsaturated fatty acid, chemistry.chemical_classification, biology, business.industry, Cell Biology, Fish oil, biology.organism_classification, Adaptation, Physiological, Enzyme assay, Vegetable oil, Fatty acid desaturase, Gene Expression Regulation, Biochemistry, chemistry, Fatty Acids, Unsaturated, biology.protein, business, Polyunsaturated fatty acid
Abstract

Highly unsaturated fatty acid (HUFA) synthesis in Atlantic salmon (Salmo salar) was known to be influenced by both nutritional and environmental factors. Here we aimed to test the hypothesis that both these effectors involved similar molecular mechanisms. Thus, HUFA biosynthetic activity and the expression of fatty acyl desaturase and elongase genes were determined at various points during an entire 2 year production cycle in salmon fed diets containing either 100% fish oil or diets in which a high proportion (75% and 100%) of fish oil was replaced by C18 polyunsaturated fatty acid-rich vegetable oil. The results showed that HUFA biosynthesis in Atlantic salmon varied during the growth cycle with peak activity around seawater transfer and subsequent low activities in seawater. Consistent with this, the gene expression of Delta6 desaturase, the rate-limiting step in the HUFA biosynthetic pathway, was highest around the point of seawater transfer and lowest during the seawater phase. In addition, the expression of both Delta6 and Delta5 desaturase genes was generally higher in fish fed the vegetable oil-substituted diets compared to fish fed fish oil, particularly in the seawater phase. Again, generally consistent with this, the activity of the HUFA biosynthetic pathway was invariably higher in fish fed diets in which fish oil was substituted by vegetable oil compared to fish fed only fish oil. In conclusion, these studies showed that both nutritional and environmental modulation of HUFA biosynthesis in Atlantic salmon involved the regulation of fatty acid desaturase gene expression.

Published
2005
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47. Plasma ghrelin response following a period of acute overfeeding in normal weight men

Author

M D Robertson, R D E Rumsey, R A Henderson, and Gunn E Vist

Subjects
Adult, Leptin, Male, medicine.medical_specialty, Peptide Hormones, Endocrinology, Diabetes and Metabolism, Growth hormone secretagogue receptor, Medicine (miscellaneous), Fatty Acids, Nonesterified, Weight Gain, Eating, Internal medicine, Blood plasma, medicine, Humans, Triglycerides, Analysis of Variance, Nutrition and Dietetics, Gastric emptying, business.industry, Body Weight, Postprandial Period, medicine.disease, Dietary Fats, Obesity, Ghrelin, Postprandial, Endocrinology, Gastric Emptying, medicine.symptom, business, Weight gain
Abstract

BACKGROUND: Ghrelin, a 28 amino-acid peptide secreted primarily from the stomach has been identified as the endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is suppressed in the postprandial state and has been linked to both type II diabetes and obesity. AIMS: To investigate the effects of a period of overfeeding with high-fat dietary supplements on plasma ghrelin levels in nonobese men. METHODS: Six healthy males (21–34 y; BMI 21–24 kg/m2) underwent the dietary intervention after completing diet and exercise diaries for 7 days. For 3 further weeks subjects followed their own diet diary supplemented with 125 ml single cream and 50 g roasted peanuts (88 g fat, 15 g Protein, 8 g carbohydrate) every day. Oral fat tolerance tests (OFTT) were undertaken at baseline, 7, 14 and 21 days of fat supplementation. The diet was increased in energy by 3.9 MJ/day and from a mean of 29–45% energy intake from fat with a small weight gain noted each week (P=0.009). RESULTS: Ghrelin concentrations were significantly reduced during the baseline OFTT. The postprandial ghrelin response (AUC) was significantly reduced following 2 weeks of dietary supplementation (P=0.005) increasing the suppression of plasma ghrelin by 18% despite only a 3% increase in body weight. Plasma triacylglycerol (P=0.009) and leptin (P=0.035) concentrations were also elevated and postprandial pancreatic polypeptide levels decreased (P=0.038) following dietary-supplementation. CONCLUSIONS: These results suggest that the metabolic profile associated with obesity, including a reduction in plasma ghrelin levels, may be related to recent dietary energy intake and precedes the development of significant adiposity.

Published
2004
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48. Replacement of dietary fish oil with increasing levels of linseed oil: Modification of flesh fatty acid compositions in Atlantic salmon (Salmo salar) using a fish oil finishing diet

Author

J. Gordon Bell, Douglas R. Tocher, John R. Sargent, and R. James Henderson

Subjects
Linseed Oil, food.ingredient, Animal feed, Clinical chemistry, Salmo salar, Xanthophylls, Biology, Biochemistry, Fish Oils, food, Linseed oil, Fatty Acids, Omega-3, Animals, Food science, Salmo, chemistry.chemical_classification, Muscles, Flesh, Fatty Acids, Organic Chemistry, food and beverages, Fatty acid, Cell Biology, beta Carotene, Fish oil, biology.organism_classification, Animal Feed, chemistry, lipids (amino acids, peptides, and proteins), Lipidology
Abstract

Five groups of salmon, of initial mean weight 127±3 g, were fed increasing levels of dietary linseed oil (LO) in a regression design. The control diet contained capelin oil (FO) only, and the same oil was blended with LO to provide the experimental diets. After an initial period of 40 wk, all groups were switched to a finishing diet containing only FO for a further 24 wk. Growth and flesh lipid contents were not affected by dietary treatment. The FA compositions of flesh total lipids were linearly correlated with dietary FA compositions (r 2=0.88–1.00, P

Published
2004
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49. Summary of a Large- and Small-Scale Unreinforced Masonry Infill Test Program

Author

W. D. Jones, J. E. Beavers, K. E. Fricke, Richard M. Bennett, and R. C. Henderson

Subjects
Engineering, business.industry, Mechanical Engineering, Frame (networking), Seismic loading, Building and Construction, Structural engineering, Masonry, Seismic wave, Cracking, Mechanics of Materials, Infill, General Materials Science, Geotechnical engineering, Unreinforced masonry building, business, Ductility, Civil and Structural Engineering
Abstract

A five-year, large- and small-scale, static and dynamic experimental research program, in which more than 700 tests were conducted, has demonstrated that unreinforced masonry infills are more ductile and resist lateral loads more effectively than anticipated by conventional code procedures. The tests were conducted both in the laboratory and on existing structures at the Department of Energy’s Y-12 National Security Complex. The experimental data indicate that the combination of a steel frame and infill material efficiently resists lateral loads—the infilling provides significant lateral stiffness while the surrounding frame adds ductility and confinement to the overall system. The results from approximately 25 moderate- and full-scale tests on infills showed that with simulated seismic loads the frames confined the masonry, and the load-carrying capacity of the infill was considerably above the load that caused initial cracking. This finding was a significant departure from classical code approaches that...

Published
2003
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50. Shifts in flood and low-flow regimes in New Zealand due to interdecadal climate variations

Author

A. I. McKERCHAR and R. D. Henderson

Subjects
Flood myth, Interdecadal Pacific Oscillation, Climatology, Streamflow, Flow (psychology), Magnitude (mathematics), Bay, Geology, Water Science and Technology
Abstract

Abstrac Thirty-one of the longest available streamflow records for New Zealand were analysed to see whether shifts in flood and low-flow regime occurred in 1977/1978 corresponding to a shift in phase of the Interdecadal Pacific Oscillation. Annual peak flows, and annual minimum flows averaged over 28 days, for two periods, 1947–1977 and 1978–1999, were compared using box plots and statistical tests. The plots and the tests show that a decrease of flood size has occurred since 1978 in the Bay of Plenty region of the North Island, and that increases in flood size and low-flow magnitude have occurred in the South Island for most rivers with headwaters draining from the main divide of the Southern Alps and Southland. For much of the North Island apart from the Bay of Plenty, and the north of the South Island, no consistent pattern of shifts was identified.

Published
2003
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