1. Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci.
- Author
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Jaholkowski, Piotr, Hindley, Guy, Shadrin, Alexey, Tesfaye, Markos, Bahrami, Shahram, Nerhus, Mari, Rahman, Zillur, OConnell, Kevin, Holen, Børge, Parker, Nadine, Cheng, Weiqiu, Lin, Aihua, Rødevand, Linn, Karadag, Naz, Frei, Oleksandr, Djurovic, Srdjan, Dale, Anders, Smeland, Olav, and Andreassen, Ole
- Subjects
GWAS ,conditional ,conjunctional false discovery rate ,genetic overlap ,polygenic architecture ,Humans ,Genome-Wide Association Study ,Vitamin D ,Schizophrenia ,Genetic Predisposition to Disease ,Polymorphism ,Single Nucleotide ,Genetic Loci - Abstract
Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known about the role of underlying shared genetic mechanisms. We applied a conditional/conjunctional false discovery rate approach (FDR) on large, nonoverlapping genome-wide association studies for SCZ (N cases = 53 386, N controls = 77 258) and vitD serum concentration (N = 417 580) to evaluate shared common genetic variants. The identified genomic loci were characterized using functional analyses and biological repositories. We observed cross-trait SNP enrichment in SCZ conditioned on vitD and vice versa, demonstrating shared genetic architecture. Applying the conjunctional FDR approach, we identified 72 loci jointly associated with SCZ and vitD at conjunctional FDR
- Published
- 2023