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Purpose: To investigate the clinical survival and success rates of conventionally luted three- and four-unit fixed dental prostheses (FDPs) with zirconia frameworks (Cercon Smart Ceramics, DeguDent) after a mean observation period of 119 ± 36 months.Materials and Methods: A total of 75 patients were treated in the Department of Prosthodontics at the University of Goettingen, Germany, and a total of 99 posterior FDPs were inserted and luted with zinc phosphate cement. Time-dependent survival and success rates were calculated using Kaplan-Meier curves, and their relationships with the type of veneer (ceramic), location (maxilla vs mandible), and span length (three-unit vs four-unit) were analyzed with a Cox regression model (P < .05).Results: Of the 99 inserted FDPs, 24 were lost to follow-up, 51 remained functional and passed the 10-year examination (overall survival rate: 75.0%; 95% confidence interval [CI]: 0.64, 0.85), and 13 were absolute failures caused by technical events (technical survival rate: 84%; 95% CI: 0.64, 0.85). In 50 FDPs, relative failure required a clinical intervention to maintain function (overall success rate: 40%; 95% CI: 0.29, 0.52). For 35 of these FDPs, the relative failure was caused by technical events (technical success rate: 61%; 95% CI: 0.49, 0.73). None of the evaluated factors showed an association with overall or technical survival or success.Conclusion: Zirconia-based posterior FDPs produced with a first-generation computer-assisted manufacturing (CAM) system revealed high rates of absolute and relative failure, mainly due to technical events, after a mean observational period of 10 years. Further clinical studies with updated computer-assisted design (CAD)/CAM systems are needed to determine the long-term performance of zirconia-based FDPs. [ABSTRACT FROM AUTHOR]

The article focuses on implementation of digital technologies in dentistry. It mentions practice management solutions, digital X-ray systems, digital photography, CAD/CAM-based processes for the manufacture of dentures and intraoral scanner systems (IOS) for digital Impressions. It also mentions tooth restoration is manufactured chairside, being high-strength glass-ceramics for partial crowns and how the future use of the IOS through current scientific knowledge.

Objective: Retrospective evaluation of the clinical performance of tooth-supported overdentures retained by resilient telescopic crowns with occlusal clearance fit (ODRTC) in severely reduced dentition (1–3 remaining teeth). Materials and methods: A total of 313 ODRTCs were inserted in an undergraduate prosthodontic program (University Medical Center, Goettingen, Germany) between 2000 und 2012. Data regarding 263 ODRTCs in 221 patients were reevaluated (observational period: 64.5 ± 34.8 months), and time-dependent survival and success rates (Kaplan-Meier-Estimator) were calculated. The number of the abutment teeth was analyzed as an influencing factor (Cox regression model (p < 0.05)). Results: The 5- and 8-year overdenture survival rates were 62% [CI: 0.55; 0.69] and 38% [CI: 0.30; 0.45]. The 5- and 8-year success-rates (biologically and technically event-free restorations) were 13% [CI: 0.09; 0.17] and 3% [CI: 0.01; 0.05]. On the abutment level, the 5- and 8-year survival rates were 55% [CI: 0.48; 0.62], and 34% [CI: 0.27; 0.42]. The number of abutment teeth significantly influenced the overdenture and abutment survival rates. Restorations with 1 or 2 abutments were significantly associated with an increased number of technical and biological complications (decementation of the primary crown, abutment fracture) compared to ODRTCs with 3 abutments. Conclusions: The survival and success rates of ODRTCs are significantly influenced by the number of abutments. Clinical relevance: For ODRTCs, reduced survival and success rates are expected, especially when only 1 or 2 abutment teeth are included. [ABSTRACT FROM AUTHOR]

We compared the characteristics of several cloned rabbit organic electrolyte (OE) transporters expressed in cultured cells with their behavior in intact rabbit renal proximal tubules (RPT) to determine the contribution of each to basolateral uptake of the weak acid ochratoxin A (OTA) and the weak base cimetidine (CIM). The activity of organic anion transporters OAT1 and OAT3 proved to be distinguishable because OAT1 had a high affinity for PAH (Kt of 20 μM) and did not support estrone sulfate (ES) transport, whereas OAT3 had a high affinity for ES (Kt of 4.5 μM) and a weak interaction with PAH (IC50 > 1 mM). In contrast, both transporters robustly accumulated OTA. Intact RPT also accumulated OTA, with OAT! and OAT3 each responsible for ∼50%: ES and PAH each reduced uptake by ∼50%, and the combination of the two eliminated mediated OTA uptake. The weak basó CIM was transported by OAT3 (Kt of 80 μM) and OCT2 (Kt of 2 μM); OCT1 had a comparatively low affinity for CIM, and CIM uptake by OAT1 was equivocal. Intact RPT accumulated CIM, with TEA and ES reducing CIM uptake by 20 and 75%, respectively, suggesting that OAT3 plays a quantitatively more significant role in CIM uptake in the early proximal tubule than OCT 1/2. In single S2 segments of RN', ES and TEA each blocked ∼50% of CIM uptake. Thus the fractional contribution of different OE transporters to renal secretion is influenced by their affinity for substrate and relative expression level in RPT. [ABSTRACT FROM AUTHOR]