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2. Exploration of effects of galvanic vestibular stimulation on circadian rhythms and its associations with sleep and spatial memory in patients with breast cancer: The ICANSLEEP-2 protocol.

Author

Galin, Melvin, de Girolamo, Laura, Clarisse, Bénédicte, Segura-Djezzar, Carine, Glöckner, Franka, Elia, Clara, Réhel, Stéphane, Clochon, Patrice, Doidy, Franck, Chavant, Julien, Etard, Olivier, Viader, Fausto, Grellard, Jean-Michel, Lequesne, Justine, Joly, Florence, Eustache, Francis, Martin, Tristan, Giffard, Bénédicte, Quarck, Gaëlle, and Perrier, Joy

Subjects
SLEEP interruptions, VESTIBULAR stimulation, SPATIAL memory, VESTIBULAR apparatus, COGNITIVE testing
Abstract

Background: Patients with breast cancer (BC) exhibit circadian rhythm disruptions, mainly of rest-activity rhythm (RAR), of which sleep is an essential component, and cortisol rhythm. Sleep complaints such as insomnia and cognitive impairments are prevalent in BC. In general population, sleep is known to contribute greatly to cognition. Thus, improving RAR (and particularly sleep) could help limiting cognitive impairments in BC patients. It has recently been suggested that, in addition to its essential role in spatial memory, the vestibular system contributes to RAR synchronization. Its stimulation could therefore limit both sleep disturbances and spatial memory deficits in BC. Objectives: The main aim of the ICANSLEEP-2 study is to assess the effects of galvanic vestibular stimulation (GVS) on circadian rhythms. The secondary aim is to assess whether GVS improves sleep and spatial memory in BC patients. Methods: Two groups with insomnia complaints (Insomnia Severity Index > 7) will be included: a patients' group with BC (n = 50) and a healthy control group without history of cancer (n = 25). There will be two assessment sessions, before and after 2 weeks of GVS. Patients will be randomly assigned to either a GVS group or a sham group (noneffective stimulation). Controls will receive GVS. GVS effects will be quantified and compared between groups. Assessments will include actigraphy, salivary cortisol, polysomnography, a cognitive test battery (including a computer-based task for spatial memory) and validated questionnaires (for psychological functioning and sleep complaints). Discussion: Current methods for improving sleep in BC have had controversial outcomes regarding sleep structure. We expect GVS to offer a new mean of directly targeting RAR disruptions in BC patients, with beneficial effects on sleep structure. Given the crucial impact of sleep on cognitive functioning, notably spatial memory, improving sleep of BC patients should enhance their cognitive functioning. Ethics and dissemination: This study received ethical approval from the Ile de France IV institutional review board on 19 April 2022 (no. ID-RCB: 2022-A00437-36). The findings yielded by this protocol will be presented at various conferences and in peer-reviewed journals. Clinicaltrials.gov registration number: NCT05414357. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Effect of cognitive reserve on the association between slow wave sleep and cognition in community-dwelling older adults.

Author

Ourry, Valentin, Réhel, Stéphane, Andre, C., Mary, Alison, Paly, Léo, Delarue, Marion, Requier, Florence, Hendy, Adam, Collette, Fabienne, Marchant, Natalie NL, Felisatti, Francesca, Palix, Cassandre, Vivien, Denis, De la Sayette, Vincent, Chételat, Gaël, Gonneaud, Julie, Rauchs, Géraldine, Medit-Ageing Research Group, Ourry, Valentin, Réhel, Stéphane, Andre, C., Mary, Alison, Paly, Léo, Delarue, Marion, Requier, Florence, Hendy, Adam, Collette, Fabienne, Marchant, Natalie NL, Felisatti, Francesca, Palix, Cassandre, Vivien, Denis, De la Sayette, Vincent, Chételat, Gaël, Gonneaud, Julie, Rauchs, Géraldine, and Medit-Ageing Research Group

Abstract

Sleep, especially slow wave sleep (SWS), is essential for cognitive functioning and is reduced in aging. The impact of sleep quality on cognition is variable, especially in aging. Cognitive reserve (CR) may be an important modulator of these effects. We aimed at investigating this question to better identify individuals in whom sleep disturbances might have greater behavioral consequences. Polysomnography and neuropsychological assessments were performed in 135 cognitively intact older adults (mean age ± SD: 69.4 ± 3.8y) from the Age-Well randomized controlled trial (baseline data). Two measures of cognitive engagement throughout life were used as CR proxies. Linear regression analyses were performed between the proportion of SWS, and executive function and episodic memory composite scores. Then, interaction analyses between SWS and CR proxies on cognition were conducted to assess the possible impact of CR on these links. SWS was positively associated with episodic memory, but not with executive function. CR proxies modulated the associations between SWS and both executive and episodic memory performance. Specifically, individuals with higher CR were able to maintain cognitive performance despite low amounts of SWS. This study provides the first evidence that CR may protect against the deleterious effects of age-related sleep changes on cognition., info:eu-repo/semantics/published

Published
2023

8. Impact de la durée de sommeil lent profond sur la charge amyloïde, la structure et la perfusion cérébrale au cours du vieillissement

Author

Le Congrès du sommeil (23–25 November 2017: Marseille, France), André, Claire, Mary, Alison, Réhel, Stéphane, Tomadesso, Clémence, Kuhn, Elisabeth, Moulinet, Inès, Mézenge, Florence, Bertran, Françoise, Chételat, Gaël, Rauchs, Géraldine, Le Congrès du sommeil (23–25 November 2017: Marseille, France), André, Claire, Mary, Alison, Réhel, Stéphane, Tomadesso, Clémence, Kuhn, Elisabeth, Moulinet, Inès, Mézenge, Florence, Bertran, Françoise, Chételat, Gaël, and Rauchs, Géraldine

Abstract

info:eu-repo/semantics/published

Published
2017

10. Kitchen Fiction

Author

Cani, Marie-Paule, Desbrun, Mathieu, Gascuel, Jean-Dominique, Réhel, Stéphane, Models, Algorithms and Geometry for Computer Generated Image Graphics (iMAGIS), Laboratoire d'informatique GRAphique, VIsion et Robotique de Grenoble (GRAVIR - IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria), Computer Science Department (CS CALTECH), California Institute of Technology (CALTECH), MoonlightI3D (ML3D), MoonlightI3D, and J. Rossignac and F. Sillion

Subjects
ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, [INFO.INFO-GR]Computer Science [cs]/Graphics [cs.GR]
Abstract

Video presented at Eurographics'96 Video Competition; International audience; no abstract

Published
1996

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