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2. Sleep attitudes as a predictor of sleep outcomes: a secondary data analysis

Author

Aria R. Ruggiero, Hannah D. Peach, Philip Zendels, and Jane F. Gaultney

Subjects
sleep attitudes, health disparities, sleep health, sleep hygiene, moderated mediation, Medicine, Psychology, BF1-990
Abstract

Objectives Attitudes have been widely studied as predictors of a number of social and health behaviors. However, attitudes predicting sleep outcomes have only recently been examined, despite sleep being conceptualized as an important health behavior. Prior research has demonstrated that attitudes toward sleep are associated with sleep hygiene, sleep duration and quality (Peach & Gaultney, ; Peach, Gaultney, Ruggiero, ). Sleep attitudes interact with varying demographic identities, such as age, gender, race, and perceived socioeconomic status (SES) (Ruggiero, Peach, & Gaultney, ). The present study hypothesized that (1) sleep attitudes would be indirectly associated with sleep outcomes (duration and quality) via sleep hygiene, and, (2) this indirect effect would be modified by specific demographic variables (age, gender, race, and perceived SES; moderated mediation). Method One hundred and seventy-two adults from the United States completed an anonymous survey on sleep characteristics and health. Results Results confirmed the first hypothesis, indicating that sleep attitudes were significantly and indirectly associated with both sleep duration and sleep quality via sleep hygiene. Additionally, gender and SES further modified these significant indirect effects, meaning hypothesis two was partially supported. Conclusions Results are discussed in terms of their implications for the importance and variability of sleep attitudes, and future research directions are considered.

Published
2020
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3. Platelet-rich plasma (PRP): history of the platelets’ concentrates and current applications in medicine

Author

M. Covelli, A. Cusanno, C. Benincasa, R. Ruggiero, C. Annichiarico, B. Marrelli, and G. Palumbo

Subjects
Dentistry, RK1-715
Abstract

Over the years, regenerative medicine has been improved thanks to new therapies and new innovative clinical protocols. The purpose of this work was to evaluate the efficacy of Platelet-rich Plasma by retracing the history of the evolution of the preparation technique, enhancing the role of platelets in tissue healing, as well as its use in various sectors of medicine. At the same time, through a critical review of recent innovations in the field of bone regeneration, was paid attention to new clinical protocols obtained from second generation platelet concentrates.

Published
2022
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5. Association of sleep attitudes with sleep hygiene, duration, and quality: a survey exploration of the moderating effect of age, gender, race, and perceived socioeconomic status

Author

Aria R. Ruggiero, Hannah D. Peach, and Jane F. Gaultney

Subjects
sleep, sleep attitudes, socioeconomic status, gender, disparities, Medicine, Psychology, BF1-990
Abstract

Objectives Sleep health is becoming more widely accepted as a possible preventative strategy against chronic disease and negative psychosocial outcomes. It is important to understand whether attitudes towards sleep vary by demographic characteristics and how potential differences in sleep attitudes could impact sleep outcomes. The present study examined whether there were demographic differences in sleep attitudes and whether the interaction between demographic characteristics and sleep attitudes impacted sleep outcomes (e.g. sleep hygiene, duration, and quality). Methods One hundred seventy-two adults from across the United States completed an anonymous survey on sleep and health. Results Sleep attitudes varied according to age, gender, and race, with more positive sleep attitudes reported by older adults, women, and those who identified as White. Although positive sleep attitudes predicted more sleep and better quality sleep, this association varied as a function of several demographic characteristics. A more complex picture arose for the interaction between demographics and sleep attitudes predicting sleep outcomes. Conclusions Future research should continue to discover for whom favorable sleep attitudes are beneficial and explore when and how sleep attitudes may be altered.

Published
2019
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7. In vitro comparative study on the mechanical behavior of Zirconia and Polyetheretherketone in applied dental sciences

Author

V, Vertucci, A, Pacifici, R, Ruggiero, L, Pacifici, M, Amantea, B, Marrelli, M, Giacomello, A, Valletta, F, Riccitiello, A, Greco Lucchina, C, Mortellaro, S, Rengo, G, Sammartino, and M, Tatullo

Subjects
Benzophenones, Dental Materials, Polymers, Materials Testing, Zirconium, Dental Restoration Failure, Ketones, Polyethylene Glycols
Abstract

Recently, Zirconia and polyaryletherketone (PEEK) have attracted increasing interest as reliable and safe materials in dental applications, mainly because of their good biomechanical characteristics. The aim of this study was to investigate the response to different loads by prosthetic frameworks for supported fixed partial dentures (FPDs), thus simulating osseointegrated implants.The specimens were divided into two groups (n= 5 each). Group A: FDPs in zirconia-ceramic; Group B: FDPs in PEEK-composite. These 2 groups were subjected to vertical loads so to evaluate structural deformation; then, they have been analyzed by scanning electron microscopy (SEM) at different magnifications.In tested samples, different types of mechanical failures have been observed. In Zirconia-specimens, chipping is the main failure noticed in this study, mostly in distal margins of the structure. Also, peek-specimens show failure and fracture.Zirconia and PEEK could be considered both good materials, but several investigations are needed to use these materials as an alternative to metals for fixed partial dentures.

Published
2023

8. Monitoring and modeling dispersal of a submerged nearshore berm at the mouth of the Columbia River, USA

Author

Andrew W. Stevens, Hans R. Moritz, Edwin P.L. Elias, Guy R. Gelfenbaum, Peter R. Ruggiero, Stuart G. Pearson, James M. McMillan, and George M. Kaminsky

Subjects
Environmental Engineering, Process-based modeling, Delft3D, Ocean Engineering, Sediment transport, Nearshore berm
Abstract

A submerged, low-relief nearshore berm was constructed in the Pacific Ocean near the mouth of the Columbia River, USA, using 216,000 m3 of sediment dredged from the adjacent navigation channel. The material dredged from the navigation channel was placed on the northern flank of the ebb-tidal delta in water depths between 12 and 15 m and created a distinct feature that could be tracked over time. Field measurements and numerical modeling were used to evaluate the transport pathways, time scales, and physical processes responsible for dispersal of the berm and evaluate the suitability of the location for operational placement of dredged material to enhance the sediment supply to eroding beaches onshore of the placement site. Repeated multibeam bathymetric surveys characterized the initial berm morphology and dispersion of the berm between September 22, 2020, and March 10, 2021. During this time, the volume of sediment within the berm decreased by about 40%to 127,000 m3, the maximum height decreased by almost 60%, and the center of the deposit shifted onshore over 200 m. Observations of berm morphology were compared with predictions from a three-dimensional hydrodynamic and sediment transport model application to refine poorly constrained model input parameters including sediment transport coefficients, bed schematization, and grain size. The calibrated sediment transport model was used to predict the amount, timing, and direction of transport outside of the observed survey area. Model simulations predicted that tidal currents were weak in the vicinity of the berm and wave processes including enhanced bottom stresses and asymmetric bottom orbital velocities resulted in dominant onshore movement of sediment from the berm toward the coastline. Roughly 50% of the berm volume was predicted to disperse away from the initial placement site during the 169 day hindcast. Between 9 and 17% of the initial volume of the berm was predicted to accumulate along the shoreface of a shoreline reach experiencing chronic erosion directly onshore of the placement site. Scenarios exploring alternate placement locations suggested that the berm was relatively effective in enhancing the sediment supply along the eroding coastline north of the inlet. The transferable monitoring and modeling framework developed in this study can be used to inform implementation of strategic nearshore placements and regional sediment management in complex, high-energy coastal environments elsewhere.

Published
2023

9. Incidence of stroke in patients with hypertrophic cardiomyopathy in stable sinus rhythm during long-term monitoring

Author

C Fumagalli, F Bonanni, M Beltrami, R Ruggiero, C Zocchi, L Tassetti, N Maurizi, M Zampieri, F Lovero, M Di Bari, N Marchionni, P Pieragnoli, F Cappelli, S Fumagalli, and I Olivotto

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Patients with hypertrophic cardiomyopathy (HCM) are at increased risk of atrial fibrillation (AF) and stroke, especially at an advanced disease stage. To date, however, the incidence and factors associated with cardioembolic events in HCM patients without AF remain unresolved. Purpose To determine the incidence of stroke in HCM patients in whom cardiac rhythm was monitored with a cardiac implantable electronic device (CIED). The association of stroke with left atrial (LA) enlargement was also examined. Methods Retrospective cohort study in an outpatient clinic in a tertiary HCM Referral Center. All consecutive patients diagnosed with HCM and referred for CIED implantation with >16 years at diagnosis and >1 year follow-up post CIED implantation were reviewed. Severe LA dilatation was defined as a LA dimension (LAD) of >48mm at echocardiogram. Based on CIED monitoring, patients were classified as: Pre-existing AF (diagnosed with AF prior to CIED); De novo AF (diagnosed with AF after CIED implantation); Sinus Rhythm (SR): no episodes of AF. Incidence of stroke after CIED implantation was the primary outcome. Results A total of 185 patients (57% men, age: 54±17 years) were implanted with a CIED and were included. Pre-existing AF was present in 72 (36%) patients and de novo AF in 24 (13%); whereas 89 (48%) remained in SR. After 5 [2–9] years, stroke was reported in 19 (10.3%) patients: 7 occurred in patients with pre-existing AF (1.1%/year), 3 in patients with de novo AF (2.2%/year), and 9 in patients with SR (2.3%/year). No difference was captured by CHA2DS2-VASc score among rhythm categories. Patients with AF had larger LAD at baseline. Among patients in SR, those with a LAD>48mm had the greatest risk of stroke (4.8%/year vs 0.5%/year, p Conclusions In HCM patients with CIED long-term monitoring and no prior history of AF, stroke rates were similar in those with de novo AF or stable sinus rhythm. CHA2DS2-VASc considerably underestimated risk, whereas severe LA dilatation was a powerful predictor of risk, irrespective of AF. Funding Acknowledgement Type of funding sources: None.

Published
2022

10. Prolonged iatrogenic thoracic duct chylous fistula in neck surgery: conservative management or surgery? A literature review

Author

Claudio Gambardella, R. Ruggiero, S. Parisi, Luigi Brusciano, D Parmeggiani, L. Docimo, G Terracciano, Giorgia Gualtieri, Parmeggiani, D, Gualtieri, G, Terracciano, G, Gambardella, C, Parisi, S, Brusciano, L, Ruggiero, R, and Docimo, L

Subjects
medicine.medical_specialty, Fistula, Conservative management, business.industry, Bile duct ligation, Incidence (epidemiology), Iatrogenic Disease, Chylous fistula, Conservative Treatment, Thoracic duct, Malignant disease, Thoracic Duct, Surgery, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, medicine, Humans, 030223 otorhinolaryngology, Complication, business
Abstract

Background: Thoracic duct chylous fistula is a rare complication following neck surgery, especially for malignant disease. Despite its low incidence, it can be a life-threatening postoperative complication increasing the risk of infection, bleeding, hypovolemia, electrolyte imbalance, and malnutrition. Currently, the management of thoracic duct fistula is not standardized yet. It can range from conservative to surgical approaches, and even when surgery indication occurs, there is no unanimous agreement on timing and operative steps, so the surgical approach still remains mostly subjective, in accordance with clinical conditions of the patients and with surgeon’s experience. Aims: The aim of the study was to search into Literature a common accepted behaviour in thoracic duct chylous fistula occurring. Methods: A literature review was carried out. Conservative treatments include fasting associated with total parental nutrition or low-fat diet, compressive dressings, and octreotide administration. If conservative treatment fails, in order to avoid dangerous consequences, functional repair of the thoracic duct injury with lymphovenous microanastomosis should be the preferred solution, rather than an approach that obliterates the thoracic duct or lymphatic–chylous pathways, such as thoracic duct embolization, therapeutic lymphangiography, and thoracic duct ligation. Conclusions: In our experience, patients undergone thyroidectomy and neck dissection for thyroid-differentiated cancer, who report an unrecognized thoracic duct chylous fistula after surgery, must be treated via integrated conservative and surgical treatment. A literature review about thoracic duct chylous fistula following neck surgery, focusing on the current management and therapeutic approach, was furthermore carried out, in order to delineate the actual therapeutic options in case of thoracic duct chylous fistula occurrence.

Published
2021

12. Gender differences affecting the relationship between sleep attitudes, sleep behaviors and sleep outcomes

Author

Jane F. Gaultney, Aria R Ruggiero, and Philip Zendels

Subjects
sex differences, Neurophysiology and neuropsychology, sleep hygiene, Sleep hygiene, QP351-495, Health outcomes, Sleep in non-human animals, BF1-990, sleep attitudes, gender differences, Psychology, sleep, General Psychology, Clinical psychology
Abstract

Research has found that discrepancies exist in many health-related behaviors, leading to discrepancies in health outcomes, between men and women. Among these, women tend to have more positive attitudes towards sleep and better sleep hygiene practices despite often having poorer sleep quality and insufficient sleep duration. The present study operationalized sleep hygiene as multi-faceted behaviors rather than a unitary construct. Using the PROCESS macro, we analyzed whether an interaction exists between gender and sleep attitudes to predict sleep hygiene, if sleep hygiene mediated the relationship between sleep attitudes and sleep outcomes, and if this indirect relationship is moderated by gender. Within our sample, gender moderated sleep attitudes predicting environment- and eating-related sleep hygiene behaviors. Sleep quality was indirectly predicted by sleep attitudes via pre-sleep arousal-related sleep hygiene behaviors. Additionally, gender moderated the indirect relationship between sleep attitudes and sleep quality through environment-related sleep hygiene behaviors. These findings reinforce the relevance of studying sleep attitudes in combination with demographic characteristics as predictors of sleep outcomes, and the usefulness of conceptualizing sleep hygiene as separable factors. It may help inform development of potential interventions intended to improve sleep and suggest directions for future studies.

Published
2021

13. Association of sleep attitudes with sleep hygiene, duration, and quality: a survey exploration of the moderating effect of age, gender, race, and perceived socioeconomic status

Author

Jane F. Gaultney, Hannah Peach, and Aria R Ruggiero

Subjects
Health (social science), media_common.quotation_subject, lcsh:BF1-990, lcsh:Medicine, socioeconomic status, 03 medical and health sciences, Behavioral Neuroscience, Race (biology), 0302 clinical medicine, gender, Quality (business), 030212 general & internal medicine, Duration (project management), Association (psychology), Socioeconomic status, Research Articles, General Psychology, disparities, media_common, 030505 public health, Sleep hygiene, lcsh:R, Sleep in non-human animals, lcsh:Psychology, sleep attitudes, Sleep, 0305 other medical science, Psychology, Psychosocial, Research Article, Clinical psychology
Abstract

Objectives Sleep health is becoming more widely accepted as a possible preventative strategy against chronic disease and negative psychosocial outcomes. It is important to understand whether attitudes towards sleep vary by demographic characteristics and how potential differences in sleep attitudes could impact sleep outcomes. The present study examined whether there were demographic differences in sleep attitudes and whether the interaction between demographic characteristics and sleep attitudes impacted sleep outcomes (e.g. sleep hygiene, duration, and quality). Methods One hundred seventy-two adults from across the United States completed an anonymous survey on sleep and health. Results Sleep attitudes varied according to age, gender, and race, with more positive sleep attitudes reported by older adults, women, and those who identified as White. Although positive sleep attitudes predicted more sleep and better quality sleep, this association varied as a function of several demographic characteristics. A more complex picture arose for the interaction between demographics and sleep attitudes predicting sleep outcomes. Conclusions Future research should continue to discover for whom favorable sleep attitudes are beneficial and explore when and how sleep attitudes may be altered.

Published
2019

14. Enhancing joint torque estimation of the workers using 3D body models

Author

G. Di Gironimo, Stanislao Grazioso, Dario Panariello, Teodorico Caporaso, Angela Palomba, R. Ruggiero, Caporaso, T., Grazioso, S., Panariello, D., Ruggiero R., Palomba, A., Di Gironimo, G., Caporaso, T., Grazioso, S., Panariello, D., Ruggiero, R., Palomba, A., and Di Gironimo, G.

Subjects
Workstation, Computer science, business.industry, 3D reconstruction, Work (physics), Solid modeling, Industrial engineering, Industrial ergonomics, law.invention, Task (project management), Software, law, 3D body scanner, Torque, 3D body measurement, business, Digitization, Digital human modeling
Abstract

The use of fast and accurate scanning systems for human worker digitization might pave the way towards the development of multiple best practices to be implemented in industry, for enhancing safety and wellness of workers. In this work, an advanced measurement system for human body 3D reconstruction is used for extracting anthropometric characteristics of a worker, which are then used for estimation of joint torques in a simulated lifting task.

Published
2021

15. Laparoscopic adrenalectomy for a giant adrenal myelolipoma: A case report

Author

F P, Tinozzi, G, Morone, B, Calì, A, Rebba, N, Osman, S, Albertario, F, Abbiati, and R, Ruggiero

Subjects
Case Report, Surgery, Laparoscopic surgery, Adrenal glands, Giant myelolipoma
Abstract

Case presentation We describe a case of a patient who presented with a mildly symptomatic, giant myelolipoma which was excised by laparoscopic approach without complications. Introduction and importance Adrenal myelolipoma (AML) is a rare tumour composed by fat and myeloid tissues. Usually it is asymptomatic, so the diagnosis is mostly incidental. It is generally located in the right adrenal gland, but it can also be found bilaterally. If its size exceeds 10 cm it is defined as a “giant myelolipoma”; in this case its treatment of choice would be adrenalectomy with an open surgical approach. Clinical discussion Patient's signs and symptoms were mild pain in the right hypochondrium and a positive right Giordano's sign. The mass was detected by a contrast-enhanced CT scan. Once excised it measured 16 cm. Conclusion Laparoscopic adrenalectomy for giant myelolipoma is a safe approach if performed by an expert surgeon, with low risk of bleeding and a better outcome for the patient., Highlights • Literature evidences are scarce regarding the surgical management of giant adrenal myelolipomas. • Laparoscopic surgery is safe and feasible even for adrenal lesions larger than 10 cm. • Clear resection margins can be obtained even for massive adrenal tumors.

Published
2022

16. Direct and Indirect Associations of Sleep Knowledge and Attitudes With Objective and Subjective Sleep Duration and Quality via Sleep Hygiene

Author

Jane F. Gaultney, Hannah Peach, and Aria R Ruggiero

Subjects
Adult, Male, Sleep Wake Disorders, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, Adolescent, media_common.quotation_subject, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Hygiene, Surveys and Questionnaires, Intervention (counseling), medicine, Humans, Sleep Hygiene, 030212 general & internal medicine, Depression (differential diagnoses), media_common, Sleep disorder, Sleep hygiene, Public health, Public Health, Environmental and Occupational Health, medicine.disease, Sleep in non-human animals, Health psychology, Female, Sleep, Psychology, Attitude to Health, 030217 neurology & neurosurgery, Clinical psychology
Abstract

Although a few studies have examined sleep knowledge and attitudes as predictors of sleep behavior, the question of which better predicts actual sleep behavior is still open. Furthermore, the construct of sleep attitudes has been inconsistently defined and measured. We examined both sleep knowledge and attitudes to determine their unique associations with sleep hygiene behaviors, and direct and indirect associations with objective and subjective sleep outcomes. College students (N = 218) completed a series of questionnaires before and after wearing a FitBit Flex accelerometer for 7 days. We collected objective sleep duration and quality using this apparatus, while participants reported subjective sleep outcomes, hygiene behaviors, knowledge, and attitudes. Analyses controlled for self-reported depression, diagnosed sleep disorder, and sleep-related medications. For both objective and subjective measures, more positive sleep attitudes but not greater sleep knowledge was directly associated with longer sleep duration, and indirectly (through sleep hygiene) with better sleep quality. The role of sleep attitudes in sleep-related behaviors and outcomes deserves further investigation as a potentially modifiable factor in sleep intervention efforts.

Published
2018

17. The role of sleep in adolescents' daily stress recovery: Negative affect spillover and positive affect bounce‐back effects ☆

Author

Amanda E. Chue, Candice A. Alfano, Aria R. Ruggiero, Rebecca W. Kim, and Kathleen C. Gunthert

Subjects
Male, medicine.medical_specialty, Adolescent, Social Psychology, Emotions, 050109 social psychology, Fitness Trackers, Audiology, Affect (psychology), 03 medical and health sciences, 0302 clinical medicine, Spillover effect, Sleep debt, Surveys and Questionnaires, Developmental and Educational Psychology, medicine, Humans, 0501 psychology and cognitive sciences, Morning, 05 social sciences, Daily stress, Moderation, Sleep in non-human animals, Affect, Psychiatry and Mental health, Pediatrics, Perinatology and Child Health, Female, Sleep onset latency, Sleep, Psychology, Stress, Psychological, 030217 neurology & neurosurgery
Abstract

The present study examined the role of sleep in daily affective stress recovery processes in adolescents. Eighty-nine American adolescents recorded their emotions and stress through daily surveys and sleep with Fitbit devices for two weeks. Results show that objectively measured sleep (sleep onset latency and sleep debt) moderated negative affective responses to previous-day stress, such that stress-related negative affect spillover effects became more pronounced as amount of sleep decreased. Total sleep time and sleep debt moderated cross-day positive affect "bounce-back" effects. With more sleep, morning positive affect on days following high stress tended to bounce back to the levels that were common following low stress days. Conversely, if sleep was short following high stress days, positive affect remained low the next morning. No evidence for subjective sleep quality as a moderator of spillover/bounce-back effects was found. This research suggests that sleep quantity could relate to overnight affective stress recovery.

Published
2018

18. 087 Gender differences in attitudes towards sleep moderate sleep hygiene behaviors

Author

Aria R Ruggiero, Hannah Peach, Jane F. Gaultney, and Philip Zendels

Subjects
Sleep hygiene, Physiology (medical), Neurology (clinical), Health behavior, Psychology, Sleep in non-human animals, Arousal, Clinical psychology
Abstract

Introduction Attitudes towards sleep have been shown to be a predictor for sleep hygiene. Sleep hygiene is the set of behaviors and conditions that promote optimal sleep, such as avoiding arousing nighttime activities, avoiding eating too close before bed, having a dark and quiet bedroom, and having a regular sleep schedule. Previous literature indicates that there are gender differences in health attitudes. This study examined whether gender differences in sleep attitudes may explain differences in sleep hygiene. Methods A sample of 172 (101 males, 71 females) individuals completed surveys through Amazon’s Mechanical Turk. Sleep attitudes were assessed using the Charlotte Attitudes Towards Sleep Scale (CATS; Peach & Gaultney, 2017). Sleep hygiene was measured using the Sleep Hygiene Practice Scale (SHPS; Lin et al; 2007; Yang et al., 2010). Males were dummy coded as 0. Other data were collected surrounding sleep outcomes, health behaviors, and demographics. Linear regression analyses were ran to examine the impact of Sleep attitudes, gender, and an interaction term on each subscale of the SHPS. Results Sleep attitudes significantly predicted each of the components of the SHPS: arousal, eating, environment, and time (b = -3.44, -2.93, -3.80, -3.04; p Conclusion This exploratory research suggested that men’s sleep-related behaviors may be more sensitive to the role of sleep attitudes. Future research should explore causes for gender differences in sleep attitudes and seek ways to improve behaviors and outcomes that are most relevant for specific demographic groups. Support (if any) Psychological Sciences department funding

Published
2021

19. Effectiveness of the Nipples-Saving Mastectomy (NSM): Review on the Results, Oncologic Safety and Surgical Complications

Author

Parmeggiani, Domenico, primary, Parmeggiani, Domenico, additional, C, Mallitti, additional, Volpe M, Lanza, additional, S, Parisi, additional, S, Rinaldi, additional, G, Nesta, additional, G, Gualtieri, additional, F, Fiorentino, additional, GM, Terracciano, additional, V, Bottino, additional, R, Ruggiero, additional, and L, Docimo, additional

Published
2020
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21. Stress-induced cardiomyopathy related to SARS-CoV-2

Author

R Ruggiero, Francesco Giannini, A Khokhar, Alessandro Sticchi, A Laricchia, A Cereda, M Toselli, A Mangieri, Antonio Colombo, and F Gallo

Subjects
business.industry, RC666-701, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Diseases of the circulatory (Cardiovascular) system, Medicine, Stress induced cardiomyopathy, business, Virology
Published
2020

23. Il Collegio Costanzo Ciano nella «città moderna» di fondazione a Napoli

Author

CASTAGNARO, ALESSANDRO, R. Ruggiero, Castagnaro, Alessandro, and R., Ruggiero

Subjects
Città di fondazione, razional-funzionalismo, altra modernità
Abstract

Il Collegio Costanzo Ciano, realizzato a Napoli tra il 1937 e il 1940 nell’area dei Campi Flegrei - zona di grandi valenze paesaggistiche, caratterizzata da alture e crateri, un tempo inedificata - rientra in un contesto di sviluppo urbano che prevedeva l’espansione ad occidente e la fondazione di una «città moderna». Il Collegio, realizzato con tecniche costruttive moderne, evocate da un razionalismo italiano con richiami al tradizionalismo locale, rientra in quel filone chiamato da Henry Russell Hitchcock (1903-1987) «della tradizione» e che la più recente storiografia italiana ha definito dell’Altra Modernità.

Published
2016

24. Design and Beam Test Results for the sPHENIX Electromagnetic and Hadronic Calorimeter Prototypes

Author

J. Smiga, E. Thorsland, A. Franz, Martin Purschke, C. A. Aidala, R. Ruggiero, S. Polizzo, M. J. Skoby, V. R. Loggins, J. LaBounty, J. L. Nagle, Anne Marie Sickles, W. Lenz, M. Sarsour, A. Sen, Shu Li, J. S. Haggerty, M. Connors, E. J. Desmond, F. Toldo, X. He, M. McCumber, C. Pontieri, S. Boose, T. Majoros, E. J. Mannel, J. Putschke, T. Rinn, J. G. Lajoie, S. P. Stoll, K. Kauder, M. Lenz, C. Pinkenburg, C. L. Woody, P. Sobel, M. Chiu, S. Beckman, P. W. Stankus, Michael William Phipps, A. Sukhanov, S. Vazquez-Carson, C. Biggs, Vanessa L. Bailey, E. Kistenev, B. Ujvari, J. Huang, R. S. Towell, J. Blackburn, R. Belmont, and M. M. Higdon

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Hadron, FOS: Physical sciences, Electron, Scintillator, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, Fermilab, Electrical and Electronic Engineering, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment, Physics, Calorimeter (particle physics), 010308 nuclear & particles physics, Instrumentation and Detectors (physics.ins-det), Nuclear Energy and Engineering, High Energy Physics::Experiment, Nucleon, Relativistic Heavy Ion Collider, Beam (structure)
Abstract

The super Pioneering High Energy Nuclear Interaction eXperiment (sPHENIX) at the Relativistic Heavy Ion Collider (RHIC) will perform high precision measurements of jets and heavy flavor observables for a wide selection of nuclear collision systems, elucidating the microscopic nature of strongly interacting matter ranging from nucleons to the strongly coupled quark-gluon plasma. A prototype of the sPHENIX calorimeter system was tested at the Fermilab Test Beam Facility as experiment T-1044 in the spring of 2016. The electromagnetic calorimeter (EMCal) prototype is composed of scintillating fibers embedded in a mixture of tungsten powder and epoxy. The hadronic calorimeter (HCal) prototype is composed of tilted steel plates alternating with plastic scintillator. Results of the test beam reveal the energy resolution for electrons in the EMCal is $2.8\%\oplus~15.5\%/\sqrt{E}$ and the energy resolution for hadrons in the combined EMCal plus HCal system is $13.5\%\oplus 64.9\%/\sqrt{E}$. These results demonstrate that the performance of the proposed calorimeter system satisfies the sPHENIX specifications., Comment: 19 pages, 31 figures, 3 tables. Published in IEEE Transactions on Nuclear Science (Volume: 65 , Issue: 12 , Dec. 2018 ). Revisions over previous version in response to referee and editor comments, plus updating of references and acknowledgement

Published
2017
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25. P788Short-coupled ventricular ectopic beats in a cohort of young patients with major cardiac events and early repolarization pattern

Author

G Calabro, Giuseppe Santarpia, Antonio Curcio, Francesco Passafaro, P Calvelli, Ciro Indolfi, S De Luca, and A R Ruggiero

Subjects
medicine.medical_specialty, Early Repolarization Pattern, business.industry, Physiology (medical), Internal medicine, Cohort, Cardiology, medicine, Ventricular Ectopic Beats, Cardiology and Cardiovascular Medicine, business
Published
2018

27. Empowering Community Health Workers with Technology Solutions

Author

R. Ruggiero, B. Buehler, and Khanjan Mehta

Subjects
Medical services, Economic growth, business.industry, Health care, General Engineering, Primary health care, General Social Sciences, Developing country, Community health workers, Biomedical communication, Rural area, business, Remedial education
Abstract

This article will provide evidence that empowering community health workers with appropriate technologies can address primary healthcare needs in developing countries. Through a comparison of case studies from various countries, a review of available resources and challenges facing CHWs, and primary data collected in Kenya, we will highlight the potential remedial impact of technology initiatives for empowering Community Health Workers.

Published
2013

28. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

Author

null Author et al, R. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. Ellis, J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez Gallego, F. Esen, G. Orhun, P. Ergin Ozcan, E. Senturk, C. Ugur Yilmaz, N. Orhan, N. Arican, M. Kaya, M. Kucukerden, M. Giris, U. Akcan, S. Bilgic Gazioglu, E. Tuzun, R. Riff, O. Naamani, A. Douvdevani, R. Takegawa, H. Yoshida, T. Hirose, N. Yamamoto, H. Hagiya, M. Ojima, Y. Akeda, O. Tasaki, K. Tomono, T. Shimazu, S. Ono, T. Kubo, S. Suda, T. Ueno, T. Ikeda, H. Ogura, H. Takahashi, J. Kang, Y. Nakamura, T. Kojima, Y. Izutani, T. Taniguchi, M. O, C. Dinter, J. Lotz, B. Eilers, C. Wissmann, R. Lott, M. M. Meili, P. S. Schuetz, H. Hawa, M. Sharshir, M. Aburageila, N. Salahuddin, V. Chantziara, S. Georgiou, A. Tsimogianni, P. Alexandropoulos, A. Vassi, F. Lagiou, M. Valta, G. Micha, E. Chinou, G. Michaloudis, A. Kodaira, H. Imaizumi, M. 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Best, A. Vercueil, G. Auzinger, A. Borgman, A. G. Proudfoot, E. Grins, K. E. Emiley, J. Schuitema, S. J. Fitch, G. Marco, J. Sturgill, M. G. Dickinson, M. Strueber, A. Khaghani, P. Wilton, S. M. Jovinge, C. Sampson, S. Harris-Fox, M. E. Cove, L. H. Vu, A. Sen, W. J. Federspiel, J. A. Kellum, C. Mazo Torre, J. Riera, S. Ramirez, B. Borgatta, L. Lagunes, J. Rello, A. K. Kuzovlev, A. Goloubev, S. Nenchuk, V. Karavana, C. Glynos, A. Asimakos, K. Pappas, C. Vrettou, M. Magkou, E. Ischaki, G. Stathopoulos, S. Zakynthinos, I. Kozhevnikova, F. Dalla Corte, S. Grasso, P. Casolari, G. Caramori, T. Andrianjafiarinoa, T. Randriamandrato, T. Rajaonera, S. El-Dash, E. L. V. Costa, M. R. Tucci, F Leleu, L Kontar, G. Bacari-Risal, M. Amato, S. El Dash, null Remmington, A. Fischer, S. Squire, M. Boichat, H. Honzawa, H. Yasuda, T. Adati, S. Suzaki, M. Horibe, M. Sasaki, M. Sanui, J. Daniel, H. Miranda, K. Milinis, M. Cooper, G. R. Williams, E. McCarron, S. Simants, I. Patanwala, I. Welters, Y. Su, J. Fernández Villanueva, R. Fernández Garda, A. López Lago, E. Rodríguez Ruíz, R. Hernández Vaquero, S. Tomé Martínez de Rituerto, E. Varo Pérez, N. Lefel, F. Schaap, D. Bergmans, S. Olde Damink, M. Van de Poll, K. Tizard, C. Lister, L. Poole, D. Ringaitiene, D. Gineityte, V. Vicka, I. Norkiene, J. Sipylaite, A. O’Loughlin, V. Maraj, J. Dowling, M. B. Velasco, D. M. Dalcomune, E. B. Dias, S. L. Fernandes, T. Oshima, S. Graf, C. Heidegger, L. Genton, V. Karsegard, Y. Dupertuis, C. Pichard, N. Friedli, Z. Stanga, L. Vandersteen, B. Stessel, S. Evers, A. Van Assche, L. Jamaer, J. Dubois, H. Castro, J. Valente, P. Martins, P. Casteloes, C. Magalhaes, S. Cabral, M. Santos, B. Oliveira, A. Salgueiro, S. Duarte, S. Castro, M. Melo, S. Gray, K. Maipang, R. Bhurayanontachai, L. G. Grädel, P. Schütz, P. Langlois, W. Manzanares, M. Lemieux, G. Elke, F. Bloos, D. Heyland, I. Aramendi, N. Babo, M. Hoshino, Y. Haraguchi, S. Kajiwara, T. Mitsuhashi, T. Tsubata, M. Aida, T. Rattanapraphat, C. Kongkamol, B. Xavier, C. Koutsogiannidis, M. Moschopoulou, G. Taskin, M. Çakir, AK Güler, A. Taskin, N. Öcal, S. Özer, L. Yamanel, J. M. Wong, C. Fitton, S. Anwar, S. Stacey, M. Aggou, B. Fyntanidou, S. Patsatzakis, E. Oloktsidou, K. Lolakos, E. Papapostolou, V. Grosomanidis, S. Gaudry, V. Desailly, P. Pasquier, PB Brun, AT Tesnieres, JD Ricard, D. Dreyfuss, A. Mignon, J. C White, A. Stilwell, G. Friedlaender, M. Peters, S. Stipulante, A. Delfosse, AF Donneau, A. Ghuysen, C. Feldmann, D. Freitag, W. Dersch, M. Irqsusi, D. Eschbach, T. Steinfeldt, H. Wulf, T. Wiesmann, J. Cholkraisuwat, S. Beitland, E. Nakstad, H. Stær-Jensen, T. Drægni, G. Andersen, D. Jacobsen, C. Brunborg, B. Waldum-Grevbo, K. Sunde, K. Hoyland, D. Pandit, K. Hayakawa, K. Kotzampassi, L. Loukipoudi, E. Doumaki, M. M. Admiraal, M. Van Assen, M. J. Van Putten, M. Tjepkema-Cloostermans, A. F. Van Rootselaar, F. Ragusa, A. Marudi, S. Baroni, A. Gaspari, E. Bertellini, T. Abdullah, S. Abdel Monem, S. Alcorn, S. McNeill, S. Russell, W. Eertmans, C. Genbrugge, I. Meex, J. Dens, F. Jans, C. De Deyne, B Avard, R Burns, A. Patarchi, T. Spina, H. Tanaka, N. Otani, S. Ode, S. Ishimatsu, J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin, M. H. Won, S. Dakova, Z. Ramsheva, K. Ramshev, A Marudi, S Baroni, A Gaspari, E Bertellini, P. E. Ozcan, S. Sencer, C. Ulusoy, M. Fallenius, M. B. Skrifvars, M. Reinikainen, S. Bendel, R. Raj, M. Abu-Habsa, C. Hymers, A. Borowska, H. Sivadhas, S. Sahiba, S. Perkins, J. Rubio, J. A. Rubio, R. Sierra, S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre, T. Groza, N. Moreau, D. Castanares-Zapatero, P. Hantson, M. Carbonara, F. Ortolano, T. Zoerle, S. Magnoni, S. Pifferi, V. Conte, N. Stocchetti, L. Carteron, T. Suys, C. Patet, H. Quintard, M. Oddo, V. Spatenkova, E. Pokorna, P. Suchomel, N. Ebert, T. Bylinski, C. Hawthorne, M. Shaw, I. Piper, J. Kinsella, A. K. Kink, I. R. Rätsep, A. Boutin, L. Moore, J. Lacroix, P. Lessard-Bonaventure, A. F. Turgeon, R. Green, M. Erdogan, M. Butler, P. Desjardins, D. A. Fergusson, B. Goncalves, B. Vidal, C. Valdez, A. C. Rodrigues, L. Miguez, G. Moralez, T. Hong, A. Kutz, P. Hausfater, D. Amin, T. Struja, S. Haubitz, A. Huber, T. Brown, J. Collinson, C. Pritchett, T. Slade, M. Le Guen, S. Hellings, R. Ramsaran, A. Alsheikhly, T. Abe, L. Kanapeckaite, R. Bahl, M. Q. Russell, K. J. Real, R. M. Lyon, N. P. Oveland, J. Penketh, M. Mcdonald, F. Kelly, M. Alfafi, W. Almutairi, B. Alotaibi, A. E Van den Berg, Y. Schriel, L. Dawson, I. A. Meynaar, D. Silva, S. Fernandes, J. Gouveia, J. Santos Silva, J. Foley, A. Kaskovagheorgescu, D. Evoy, J. Cronin, J. Ryan, M. Huck, C. Hoffmann, J. Renner, P. Laitselart, N. Donat, A. Cirodde, J. V. Schaal, Y. Masson, A. Nau, O. Howarth, K. Davenport, P. Jeanrenaud, S. Raftery, P. MacTavish, H. Devine, J. McPeake, M. Daniel, T. Quasim, S. Alrabiee, A. Alrashid, O. Gundogan, C. Bor, E. Akýn Korhan, K. Demirag, M. Uyar, F. Frame, C. Ashton, L. Bergstrom Niska, P. Dilokpattanamongkol, T. Suansanae, C. Suthisisang, S. Morakul, C. Karnjanarachata, V. Tangsujaritvijit, S. Mahmood, H. Al Thani, A. Almenyar, S. E. Morton, Y. S. Chiew, C. Pretty, J. G. Chase, G. M. Shaw, P. Kordis, V. Grover, I. Kuchyn, K. Bielka, Z. Aidoni, G. Stavrou, C. Skourtis, S. D. Lee, K. Williams, I. D. Weltes, S. Berhane, C. Arrowsmith, C. Peters, S. Robert, R. B. Panerai, T. G. Robinson, E. Borg-Seng-Shu, M. De Lima Oliveira, N. C. Mian, R. Nogueira, S. P. Zeferino, M. Jacobsen Teixeira, P. Killeen, M. McPhail, W. Bernal, J. Maggs, J. Wendon, T. Hughes, L. U. Taniguchi, E. M. Siqueira, J. M. Vieira Jr, L. C. Azevedo, A. N. Ahmad, E. Helme, S. Hadfield, J. Shak, C. Senver, R. Howard-Griffin, P. Wacharasint, P. Fuengfoo, N. Sukcharoen, R. Rangsin, D. Sbiti-Rohr, H. Na, S. Song, S. Lee, E. Jeong, K. Lee, E. Zoumpelouli, E. A Volakli, V. Chrysohoidou, K. Charisopoulou, E. Kotzapanagiotou, K. Manavidou, Z. Stathi, B. AlGhamdi, Q. Marashly, K. Zaza, M. Khurshid, Z. Ali, M. Malgapo, M. Jamil, A. Shafquat, M. Shoukri, M. Hijazi, F. A. Rocha, K. Ebecken, L. S. Rabello, M. F. Lima, R. Hatum, F. V. De Marco, A. Alves, J. E. Pinto, M. Godoy, P. E. Brasil, F. A. Bozza, J. I. Salluh, M. Soares, J. Krinsley, G. Kang, J. Perry, H. Hines, K. M. Wilkinson, C. Tordoff, B. Sloan, M. C. Bellamy, E. Moreira, F. Verga, M. Barbato, G. Burghi, M Soares, U. V. Silva, A. P. Torelly, J. M. Kahn, D. C. Angus, M. F. Knibel, R. Marshall, T. Gilpin, D. Mota, B. Loureiro, J. Dias, O. Afonso, F. Coelho, A. Martins, F. Faria, H. Al Orainni, F. AlEid, H. Tlaygeh, A. Itani, A. Hejazi, J. Messika, J. D. Ricard, S. Guillo, B. Pasquet, E. Dubief, F. Tubach, K. James, P. Temblett, L. Davies, C. Lynch, S. Pereira, S. Cavaco, J. Fernandes, I. Moreira, E. Almeida, F. Seabra Pereira, M. Malheiro, F. Cardoso, I. Aragão, T. Cardoso, M. Fister, P. Muraray Govind, N. Brahmananda Reddy, R. Pratheema, E. D. Arul, J. Devachandran, N. Chin-Yee, G. D’Egidio, K. Thavorn, K. Kyeremanteng, A. G. Murchison, K. Swalwell, J. Mandeville, D. Stott, I. Guerreiro, C. Goossens, M. B. Marques, S. Derde, S. Vander Perre, T. Dufour, S. E. Thiessen, F. Güiza, T. Janssens, G. Hermans, I. Vanhorebeek, K. De Bock, G. Van den Berghe, L. Langouche, B. Miles, S. Madden, M. Weiler, P. Marques, C. Rodrigues, M. Boeira, K. Brenner, C. Leães, A. Machado, R. Townsend, J. Andrade, R. Kishore, C. Fenlon, T. Fiks, A. Ruijter, M. Te Raa, P. Spronk, P. Docherty, J. Dickson, E. Moltchanova, C. Scarrot, T. Hall, W. C. Ngu, J. M. Jack, A. Pavli, X. Gee, E. Akin Korhan, M. Shirazy, A. Fayed, S. Gupta, A. Kaushal, S. Dewan, A. Varma, E. Ghosh, L. Yang, L. Eshelman, B. Lord, E. Carlson, R. Broderick, J. Ramos, D. Forte, F. Yang, J. Feeney, K. Wilkinson, K. Shuker, M. Faulds, D. Bryden, L. England, K Shuker, A Tridente, M Faulds, A Matheson, J. Gaynor, D Bryden, S South Yorkshire Hospitals Researc ᅟ, B. Peroni, R. Daglius-Dias, L. Miranda, C. Cohen, C. Carvalho, I. Velasco, J. M. Kelly, A. Neill, G. Rubenfeld, N. Masson, A. Min, E. Boezeman, J. Hofhuis, A. Hovingh, R. De Vries, G. Cabral-Campello, M. Van Mol, M. Nijkamp, E. Kompanje, P. Ostrowski, K. Kiss, B. Köves, V. Csernus, Z. Molnár, Y. Hoydonckx, S. Vanwing, V. Medo, R. Galvez, J. P. Miranda, C. Stone, T. Wigmore, Y. Arunan, A. Wheeler, Y. Wong, C. Poi, C. Gu, P. Molmy, N. Van Grunderbeeck, O. Nigeon, M. Lemyze, D. Thevenin, J. Mallat, M. Correa, R. T. Carvalho, A. Fernandez, C. McBride, E. Koonthalloor, C. Walsh, A. Webber, M. Ashe, K. Smith, E. A. Volakli, M. Dimitriadou, P. Mantzafleri, O. Vrani, A. Arbouti, T. Varsami, J. A. Bollen, T. C. Van Smaalen, W. C. De Jongh, M. M. Ten Hoopen, D. Ysebaert, L. W. Van Heurn, W. N. Van Mook, A. Roze des Ordons, P. Couillard, C. Doig, R. V. Van Keer, R. D. Deschepper, A. F. Francke, L. H. Huyghens, J. B. Bilsen, B. Nyamaizi, C. Dalrymple, A. Dobru, E. Marrinan, A. Ankuli, R. Struthers, R. Crawford, P. Mactavish, P. Morelli, M. Degiovanangelo, F. Lemos, V. MArtinez, J. Cabrera, A. Rutten, S. Van Ieperen, S. De Geer, M. Van Vugt, E. Der Kinderen, A. Giannini, G Miccinesi, T Marchesi, and E Prandi

Subjects
0301 basic medicine, 03 medical and health sciences, medicine.medical_specialty, 030219 obstetrics & reproductive medicine, 030104 developmental biology, 0302 clinical medicine, business.industry, Intensive care, Emergency medicine, Medicine, Critical Care and Intensive Care Medicine, business
Published
2016

29. Immunity to bacterial infection (excluding mycobacteria) (PP-060)

Author

T. Majumdar, Y. Shen, T. Ikebe, H. Galkowska, A. Razavi, S. Lu, Z. Lacinova, M. Kalani, I. T. Lin, E. P. Koroleva, D. Hu, T. Tsubata, M. van Meurs, G. Fernández, F. Shokri, M. S. Blake, O. G. Ribeiro, K. Onozaki, Y. Fu, A. Retamal, C. Yeh, I. Gjertsson, Y. Gan, L. Henningsson, S. Goyert, T. Nomura, I. Choi, S. Daim, A. Straskova, L. C. Peters, A. Borrego, S. V. Melnikova, M. Shekarabi, T. E. Michaelsen, B. Rearte, A. Ribeiro, A. V. Kruglov, M. L. Nilles, A. Rivera, E. B. Andrade, T. Takii, P. Fernández, T. Tsuji, D. L. W. Chong, A. Nakane, M. Farhadi, E. N. De Gaspari, Y. Emoto, J. Silver, J. S. Gunn, H. Nanbara, M. Tebianian, Y. Yoshida, J. Stulik, O. Secka, O. M. Rybakova, R. Pastelin-Palacios, M. Antonio, H. Kobayashi, T. Nagasawa, A. A. Oñate, J. Kelly, S. A. Nedospasov, M. Pevsner-Fischer, V. P. Zav'yalov, J. Bruzzo, M. A. Moreno Eutimio, S. Metkar, M. Mitsuyama, S. A. Popova, M. Ramírez-Aguilar, A. V. Tumanov, C. López-Macías, D. Gazivoda, I. Kawamura, R. J. Ingram, H. Osório, J. J. Wu, P. R. Castro, A. Galvan, A. Maglioco, S. Koyasu, S. Kiany, A. V. Tretiyakova, P. Spidlova, S. Blazickova, K. Narita, P. Ferreira, N. Williams, T. Eneljung, K. A. Hodgson, S. Tanaka, M. Ato, C. Q. Ma, T. A. Dragani, T. Kokubo, N. Levchik, R. Riquelme, A. Sikora, N. Tsao, M. Tsuiji, R. Botek, M. Tanaka, A. Rezaei Mokarram, R. Adegbola, M. Shoji, L. Cerrvantes-Barragan, M. Yousefi, M. Popovic, C. Gil-Cruz, L. V. Mikhina, Y. Hara, T. Matsumura, H. Watanabe, G. Lackovic, M. Kroca, L. Eisenbach, L. N. Nesterenko, S. Ebrahimi, T. Ferreira, L. Bonifaz, M. Emoto, A. Magryś, Y. C. Chang, M. Jarrah Zadeh, J. Marek, C. H. Hung, Y. Iwakura, S. Howie, A. Yoshimura, S. Yona, R. Yashiro, J. Paluch-Oleś, N. Yokobori, M. Taghizadeh, K. M. Lam, M. Yano, S. J. Park, J. Wang, H. Valpotic, T. Noguchi, L. Wei, Y. Lim, W. Olszewski, C. Bin, S. Wongratanacheewin, Z. Piao, K. Tsuchiya, A. Osanai, D. S. Bradley, N. I. Shapiro, O. A. Karpova, A. Mitani, R. Shahrami, S. Sriskandan, C. Jung, T. Dzopalic, K. H. Seo, S. C. Clarke, S. Tomic, L. Cerveny, D. Vucevic, N. Imai, T. Canhamero, N. Starobinas, H. Lin, R. Ruggiero, A. Zavaran Hoseini, Y. Matsumura, W. H. K. Cabrera, S. N. Faust, K. Kobayashi, K. V. Shumilov, S. Dramsi, E. Silverpil, J. A. Boch, T. Shimizu, T. Faal, E. Abbasi, I. R. Cohen, S. Matsushita, A. Cordeiro-da-Silva, Y. y. Guo, J. Morris, M. Salari, F. Golsaz-Shirazi, H. Jung, Y. S. Lin, N. Vijtjuk, Y. H. Chou, D. Park, F. Rahimi Bashar, J. M. Jefferies, Y. J. Kim, T. N. Cunha, H. Qu, T. Kikuchi, K. Hiromatsu, M. Markova, K. Nakayama, D. V. Kuprash, Y. Koyama, K. Haruyama, B. K. L. Langerud, Y. Xu, N. Wara-aswapati, L. Arriaga-Pizano, S. I. Han, M. Talebi-Taher, M. Kozioł-Montewka, M. Wójtowicz, W. Brigitte, M. Akkoyunlu, C. Tien, D. Saez, C. I. Pérez-Shibayama, G. Zhang, D. V. Balunets, D. Spoljaric, A. Memarnejadian, P. A. MacAry, P. Trieu-Cuot, B. Govan, T. Suga, G. Kamoshida, K. Asano, E. Hamada, N. V. Kobets, E. García-Zepeda, I. Valpotic, A. Puangpetch, S. Vasilijic, N. Cohen, Y. Bando, C. F. Kuo, R. Anderson, N. Ketheesan, H. Chen, S. Mazumder, G. Gu, C. Poyart, M. Christodoulides, L. Oliveira, R. Margailt, A. Moravej, A. Dragicevic, F. Bozic, K. S. Kim, P. Jirholt, S. Kharb, M. Correira-Neves, K. Janatova, A. Bojang, R. Itoh, J. Djokic, A. Podbielska, E. Stelmach, F. Vorraro, A. Linden, S. Charan, F. Ebrahimi Taj, K. Yano, Y. Y. Wu, J. R. Jensen, S. D. Dewamitta, J. N. Kim, C. Lindholm, A. Tabatabaei, A. Kovšca-Janjatović, D. E. Lowther, M. Isturiz, N. Katsenelson, W. C. Aird, T. Yamamoto, M. Aino, T. Nagai, N. Sohrabi, J. Khoshnoodi, A. A. Denisov, M. Kishimoto, V. A. Magalhães, C. Guzmán, S. Kanswal, Y. S. Korobovtseva, N. Gerasimova, C. Alpuche-Aranda, J. Chia, S. Itoh, I. K. G. Andreasson, J. Alves, H. Hara, C. Chiu, S. Chiba, Y. Abiko, M. Colic, M. Barati, D. Caugant, M. Naito, V. Melichacova, Y. Wang, P. Cejkova, S. Jung, M. Santic, R. Wongratanacheewin, M. Rasouli, M. De Franco, F. Tahmasebi, D. M. Altmann, H. Sashinami, G. Makenzie, K. M. Salmakov, S. Yeo, S. Noorbakhsh, M. Cerna, A. S. Tocheva, F. Ike, A. Isibasi, O. Voronova, Y. Izumi, N. D. Lambert, O. M. Ibañez, P. Madureira, O. D. Sklyarov, K. Dubravko, S. Sakai, I. Becker, H. y. Gu, L. Balboa, and A. S. Apt

Subjects
Immunity, Immunology, Immunology and Allergy, General Medicine, Biology, Microbiology
Published
2010

32. PHENIX magnet system

Author

R. Thern, W. Guryn, R. Jayakumar, R. Schleuter, John D. Jackson, O. Fackler, Y. Severgin, S. Migluolio, W.E. Sondheim, J. Chiba, M. Libkind, G. Riabov, A.R. Harvey, A. Franz, Wuzheng Meng, S. H. Aronson, R. Ruggiero, C. Velissaris, R. Prigl, J. H. Thomas, T. K. Shea, N. Saito, S.A. Kahn, A. Drees, J.P. Freidberg, A. Shajii, F. Messer, V. Vasiliev, J. Bowers, V.V. Kashikhin, G. T. Danby, Ryo Yamamoto, P. J. Kroon, T. Ichihara, I. D. Ojha, V. Shangin, Kazuhiro Tanaka, and M. D. Marx

Subjects
Physics, Nuclear and High Energy Physics, Field (physics), business.industry, Solenoid, Magnetic field, Nuclear physics, Optics, Electromagnetic coil, Magnet, Pseudorapidity, business, Instrumentation, Beam (structure), Excitation
Abstract

The PHENIX magnet system is composed of three spectrometer magnets with warm iron yokes and water-cooled copper coils. The Central Magnet (CM) is energized by two pairs of concentric coils and provides a field around the interaction vertex that is parallel to the beam. This allows momentum analysis of charged particles in the polar angle range from 70° to 110°. The north and south Muon Magnets (MMN and MMS) use solenoid coils to produce a radial magnetic field for muon analysis. They each cover a pseudorapidity interval of 1.1–2.3 and full azimuth. The coils are wound on cylindrical surfaces at the end of large tapered pistons. Each of the three magnets provides a field integral of about 0.8 T -m. The physical and operating parameters of the magnets and their coils are given along with a description of the magnetic fields generated. The geometric, thermal and magnetic analysis leading to the coil design is discussed. The magnetic volumes of the PHENIX magnets are very large and complex, so a new technique was developed to map the fields based on surface measurements of a single field component using single axis Hall probes mounted on a rotating frame. A discussion of the performance of the CM during the first year of PHENIX running is given.

Published
2003

33. The contribution of laparoscopy to the treatment of gastric cancer

Author

C. Bettonica, C. Ballesta Lopez, E. Procaccini, R. Ruggiero, and I. Poves

Subjects
Laparoscopic surgery, Billroth II, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Stomach, Pylorus, Surgery, medicine.anatomical_structure, Laparotomy, medicine, Lymphadenectomy, Gastrectomy, Laparoscopy, business
Abstract

Laparoscopy plays a role in the preoperative diagnosis of gastric cancer, particularly in determining the location and extent of the neoplasia. In addition to its use in staging, laparoscopy is indicated for the gastric resection of T1-T2, and its middle- and long-term results are comparable to those obtainable with open surgery. Herein we describe our experience with the laparoscopic resection of gastric carcinomas, including the dissection of lymph nodes and the Billroth II reconstruction of digestive continuity with gastroje-junostomia. We carried out laparoscopic gastric resections in 25 patients with adenocarcinomas. Our method involved installing five trocars, tying the left and right gastric vessels and the right gastro-epiploic vessels, sectioning the duodenum 3 cm from the pylorus, sectioning the remaining portion of the stomach obliquely 3 cm from the cardias, and performing Billroth II reconstruction. The average duration of the operation was 4 h 45 min. The average number of removed lymph nodes was 30.5 (range, 22–41). Five patients were converted to laparotomy. Significant complications were observed in four cases (16%). Hospitalization ranged from 5 to 16 days. The average follow-up was 38 months (range, 7–63), without evidence of relapse. In terms of morbidity, our results were similar to those obtained with open surgery. Lymphectomy according to the extent and number of lymph nodes is acceptable in the treatment of tumors of the lower third of the stomach. More case studies are needed to provide further indications of the applicability of the technique (which is currently used only in a few centers) and long-term results.

Published
2002

35. SPECT: Stato dell'arte

Author

M. C. Buonocore, E. Leone, R. Ruggiero, E. Covelli, and G. Carannante

Subjects
Radiological and Ultrasound Technology, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), business
Published
1999

38. Glutathione peroxidase (GPX) activity in seminal plasma of healthy and infertile males

Author

S. Zarrilli, A. Cimmino, G. Lombardi, A. Colao, B. Di Rosario, R. Smeraglia, M. De Rosa, Angela Giannattasio, R. Ruggiero, A., Giannattasio, M., DE ROSA, R., Smeraglia, Zarrilli, Stefano, A., Cimmino, B., DI ROSARIO, R., Ruggiero, A., Colao, and G., Lombardi

Subjects
Adult, Male, medicine.medical_specialty, GPX3, Endocrinology, Diabetes and Metabolism, Glutathione reductase, chemistry.chemical_compound, Endocrinology, Semen, Internal medicine, medicine, Humans, Infertility, Male, chemistry.chemical_classification, Glutathione Peroxidase, biology, Sperm Count, Glutathione peroxidase, Healthy subjects, Glutathione, infertile males, Glutathione peroxidase activity, Enzyme, chemistry, biology.protein, seminal plasma, Sperm Motility, Peroxidase, Hormone
Abstract

Human spermatozoa are more dependent on glutathione peroxidase/glutathione reductase (GPX/GR) system, via reduced glutathione (GSH), to inactivate reactive oxygen metabolites (ROMs) such as hydrogen peroxide and organic hydroperoxides. To demonstrate whether there is a substantial difference in GPX activity between normal and pathological seminal plasma, we decided to evaluate the activity of this enzyme in healthy subjects and infertile males with normal hormonal patterns. Our results demonstrate that in healthy subjects the seminal plasma contains a GPX activity that is about 10 times greater than the GPX activity detected in the seminal plasma of infertile males. By using specific antibodies against plasmatic GPX (GPX3), we also demonstrate that enzymatic activity, detected in the seminal plasma of both healthy and infertile males is GPX3. Therefore, the evaluation of GPX activity in human seminal plasma could be a new useful marker of gonadal function in men.

Published
2003

39. Making the economic case for bulk energy storage in electric power systems

Author

John R. Ruggiero and Gerald T. Heydt

Subjects
Pumped-storage hydroelectricity, Energy recovery, Engineering, Wind power, business.industry, Distributed generation, Intermittent energy source, Electrical engineering, Grid energy storage, business, Energy technology, Process engineering, Energy storage
Abstract

Bulk energy storage has often been suggested for large scale electric power systems in order to levelize load; store energy when it is inexpensive and discharge energy when it is expensive; potentially defer transmission and generation expansion; and provide for generation reserve margins. As renewable energy resource penetration increases, the uncertainty and variability of wind and solar may be alleviated by bulk energy storage technologies. This research addresses the economic case for bulk energy storage optimized for multiple objectives including decreasing generation costs and peak shaving. The test bed used is the Arizona electric transmission system.

Published
2013

40. Gigantic Paget disease of the breast

Author

A. Morelli Coghi, G.S. Toussoun, R. Ruggiero, Silvia Scevola, and Giovanni Nicoletti

Subjects
musculoskeletal diseases, medicine.medical_specialty, business.industry, Paget's Disease, Mammary, General surgery, Carcinoma, Ductal, Breast, Breast Neoplasms, General Medicine, Plastic Surgery Procedures, Thoracic Neoplasms, Treatment Outcome, Surgical Procedures, Operative, Rare case, Paget Disease, otorhinolaryngologic diseases, medicine, Humans, Female, Surgery, Thoracic Wall, Surgical treatment, business, Breast reconstruction, Aged
Abstract

A rare case of gigantic Paget disease is presented. Surgical treatment and reconstructive issues are discussed in detail.

Published
2004

41. La radiochirurgia stereotassica dei gliomi ad alto grado

Author

F. Smaltino, O. Catalano, R. Ruggiero, A. Frusciante, and F. Fortunato

Subjects
Radiological and Ultrasound Technology, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), business
Published
1994

42. [Bilio-intestinal bypass in the treatment of metabolic syndrome in obese patient]

Author

R, Ruggiero, G, Docimo, V, Russo, L, Sparavigna, I, Verde, P, Capuano, A, Topatino, S, Gili, V, Amoroso, A L, Mozzillo, E, Iovinella, R, D'Anna, A, Bosco, and L, Docimo

Subjects
Adult, Male, Metabolic Syndrome, Middle Aged, Biliopancreatic Diversion, Body Mass Index, Obesity, Morbid, Treatment Outcome, Jejunoileal Bypass, Weight Loss, Quality of Life, Humans, Female, Laparoscopy, Follow-Up Studies, Retrospective Studies
Abstract

obesity (O) is a chronic patologic condition, evolutive and relapsing, with multifactorial etiopathogenesis, consisting in an alteration of the body's composition characterized by a relative and absolute excess of fat, that gets worse the life quality and causes complications that can lead to death.experience concerns twenty-five diabetic obese patients underwent bilio-intestinal by-pass between January 2006-December 2007. All these patients, before the surgical operation, underwent a rigorous clinical and laboratory examination. Besides, a precise rate control of laboratory, overlap with those performed in the pre-operative period of operation, was required for each patient: the first after one month, the second after six months and the third after twelve months.the average weight loss was about 40 kg and, more important, these data show that the BMI is reduced, until to become stable, after 12 months from surgical operation, about values 34-31 Kg/m², obtaining, in this way, an improvement of values in the development metabolic syndrome and, above all, heart rate and ventricular repolarization.the data obtained by our study support the hypothesis to suggest the operations of bariatric malassorbing surgery, in particular bilio-intestinal by-pass, as prophylactic methods for dismetabolics diseases, with reduction of cardiovascular risk in obese patient.

Published
2011

44. Bronchoalveolar lavage in idiopathic pulmonary fibrosis: what does it tell us?

Author

E. Ricchiuti, R. Ruggiero, Alberto Pesci, A. De Micheli, Pesci, A, Ricchiuti, E, Ruggiero, R, and De Micheli, A

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Non-specific interstitial pneumonia, Prognosi, Neutrophils, Eosinophil, Malignancy, Bronchoalveolar Lavage, Idiopathic pulmonary fibrosis, Usual interstitial pneumonia, Pulmonary fibrosis, medicine, Humans, Clinical significance, Lymphocytes, medicine.diagnostic_test, MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, business.industry, Respiratory disease, Neutrophil, Idiopathic Pulmonary Fibrosi, respiratory system, medicine.disease, Prognosis, humanities, Idiopathic Pulmonary Fibrosis, respiratory tract diseases, Eosinophils, Bronchoalveolar lavage, Lymphocyte, business, Bronchoalveolar Lavage Fluid
Abstract

SummaryBronchoalveolar lavage (BAL) has only a limited role in diagnosis of idiopathic pulmonary fibrosis (IPF). A finding of raised neutrophils (>5%) and eosinophils (>2%) is characteristic but not diagnostic of IPF. BAL cell count does not clearly differentiate between fibrotic non-specific interstitial pneumonia and IPF either diagnostically or prognostically. BAL in IPF should be considered in all patients with suspected infection, malignancy or acute exacerbations. In such cases, it may be diagnostic. Because of few and conflicting results BAL fluid analysis has very little clinical relevance determining prognosis and response to treatment in IPF.

Published
2010

45. Metachronous Paget's disease of the breast: case report

Author

A, Gubitosi, G, Moccia, F A, Malinconico, G, Iside, F, Gilio, C, Cognetti, F, Foroni, G, Docimo, R, Ruggiero, L, Docimo, and M, Agresti

Subjects
Biopsy, Paget's Disease, Mammary, Carcinoma, Ductal, Breast, Breast Neoplasms, Neoplasms, Second Primary, Humans, Lymph Node Excision, Female, Breast, Mastectomy, Radical, Tomography, X-Ray Computed, Aged, Mammography, Neoplasm Staging
Abstract

Paget breast disease is a kind of intraductal carcinoma that through an intracanalicular diffusion invades the basal epidermal layer, reaching the areola and nipple, producing a typical erythematous desquamative eczematous-like lesion. This neoplasia can remain undetected for a long time and inadequately treated as a dermatological affection. Synchronous or metachronous lesions are very uncommon. Surgical choice is conditioned by the presence of a tumor below the epidermal lesion, by its dimensions, and by the possible lymph node involvement. Surgical therapy can be radical or conservative. From our experience we think that lesion biopsy is always necessary to formulate a correct diagnosis and to schedule an appropriate therapeutic approach. In our case, a biopsy was performed first, then on the basis of the frozen section analysis a radical mastectomy with axillary third level lymph nodes dissection, because of the large dimensions of the lesion and the previous history of a methachronous lesion.

Published
2009

46. [Conservative anal fistula treatment with collagenic plug and human fibrin sealant. Preliminary results]

Author

A, Gubitosi, G, Moccia, F A, Malinconico, G, Docimo, R, Ruggiero, G, Iside, N, Avenia, L, Docimo, F, Foroni, F, Gilio, L, Sparavigna, and M, Agresti

Subjects
Male, Swine, Fibrin Tissue Adhesive, Middle Aged, Extracellular Matrix, Recurrence, Absorbable Implants, Animals, Humans, Rectal Fistula, Female, Tissue Adhesives, Collagen, Horses, Aged, Retrospective Studies
Abstract

The authors, on the basis of a long clinical experience with human fibrin glue in general surgery, compared two different extracellular matrix (collagen), Surgisis and TissueDura, with human fibrin glue, applied during the operation, and sometimes in postoperative, to obtain the healing of perianal fistulas. The collagenic extracellular matrix provides, according to the rationale suggested, an optimal three-dimensional structure for the fibroblastic implant and neoangiogenesis, hence for the fistula "fibrotizzation" and closure. The encouraging results for transphincteric fistulas and a simple and easy technique push to researchers on samples statistically significant.

Published
2009

47. Fibrin glue to reduce seroma after axillary lymphadenectomy for breast cancer

Author

R, Ruggiero, E, Procaccini, S, Gili, C, Cremone, G, Docimo, G, Decimo, F, Iovino, L, Docimo, L, Decimo, L, Sparavigna, A, Gubitosi, A, Subitosi, D, Parmeggiani, and N, Avenia

Subjects
Mastectomy, Modified Radical, Seroma, Axilla, Humans, Lymph Node Excision, Breast Neoplasms, Female, Tissue Adhesives, Fibrin Tissue Adhesive, Prospective Studies, Adenocarcinoma, Mastectomy, Segmental
Abstract

Axillary lymphadenectomy remains an integral part of breast cancer treatment, yet seroma formation occurs in 15-85% of cases. Among the methods employed to reduce seroma magnitude and duration, fibrin glue has been proposed in numerous studies with controversialSixty patients underwent quadrantectomy or mastectomy with level I/II axillary lymphadenectomy; a suction drain was fitted in all patients. Fibrin glue spray was applied to the axillary fossa in 30 patients; the other 30 patients were treated conventionally. Suction drainage was removed between postoperative days III and IV. Seroma magnitude and duration were significantly reduced (P=0.004 and 0.02, respectively), and there were fewer evacuative punctures, in patients receiving fibrin glue compared with the conventional treatment group. The authors conclude that the use of fibrin glue does not always prevent seroma formation, but does reduce seroma magnitude, duration and necessary evacuative punctures.

Published
2008

48. ATLAS liquid argon calorimeter front end electronics

Author

A Perus, R Bernier, W. E. Cleland, H. S. Chen, Ning Zhou, M. L. Chu, S. Simion, I. Katsanos, M. Cooke, S. Duffin, H. M. Braun, Dirk Zerwas, Bruno Mansoulie, L. Chen, S. Rescia, P. Zarzhitsky, E. Auge, J.P. Richer, Shuai Liu, I. Wingerter-Seez, Abdeslam Hoummada, Vikas Bansal, K. Benslama, Ryszard Stroynowski, N. Dumont-Dayot, Daniel Fournier, J. Fent, Ph. Schwemling, M.-L. Gallin-Martel, Shih-Chang Lee, C. Boulahouache, Douglas Gingrich, Francesco Lanni, Th. Müller, P. Perrodo, J. Teiger, N. Massol, Fabrice Hubaut, D. S. Su, Marc Escalier, Luis Hervas, O. Le Dortz, Denis Oliveira Damazio, B. Liu, D. Breton, C.-Y. Chi, I. Falleau, Ph Martin, M. Bouchel, T. Hott, W. Sippach, P. Imbert, Veljko Radeka, J. Ban, S. Boettcher, P. Eckstein, K. Copic, E. Delagnes, Evgueni Ladygin, Hong Ma, Mauro Citterio, D. Dannheim, B. Dinkespiler, J-J Veillet, Marcello Mazzanti, James Kierstead, J. A. Parsons, N. J. Buchanan, Bertrand Laforge, Bengt Lund-Jensen, G. Martin-Chassard, V. Tocut, J. Rabel, A. Gara, D. Lissauer, A. Le Coguie, D. Dzahini, Gustaaf Brooijmans, X. De La Broise, Andy Haas, D. Makowiecki, P. Borgeaud, Johann Collot, N. Seguin Moreau, J. Pascual, Helio Takai, Jingbo Ye, T. Liu, L. Serin, L. Zhang, H. Ghazlane, P. Hansson, S. Kandasamy, K. J. Grahn, J. Colas, A Bozzone, K Wolniewicz, S. Caughron, G Perrot, M. J. Kobel, L. Kurchaninov, W D Cwienk, Ping-Kun Teng, F. Densing, J. McDonald, V. Savinov, R Ruggiero, F. Tartarelli, J. Farrell, G. Zuk, V. Paolone, C. De La Taille, Henric George Wilkens, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, ATLAS, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics::Instrumentation and Detectors, chemistry.chemical_element, Electronic detector readout concepts (gas, liquid), 01 natural sciences, Calorimeters, Optics, Data acquisition, Atlas (anatomy), Front-end electronics for detector readout, 0103 physical sciences, medicine, Electronics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, 010306 general physics, Instrumentation, Mathematical Physics, Physics, Large Hadron Collider, Argon, 010308 nuclear & particles physics, business.industry, Electrical engineering, Calorimeter, medicine.anatomical_structure, chemistry, Liquid argon, Measuring instrument, High Energy Physics::Experiment, business
Abstract

The ATLAS detector has been designed for operation at CERN's Large Hadron Collider. ATLAS includes a complex system of liquid argon calorimeters. This paper describes the architecture and implementation of the system of custom front end electronics developed for the readout of the ATLAS liquid argon calorimeters.

Published
2008

49. Pharmacovigilance and reporting oversight in US FDA fast-track process: bisphosphonates and osteonecrosis of the jaw

Author

Edwards, B.J. Gounder, M. McKoy, J.M. Boyd, I. Farrugia, M. Migliorati, C. Marx, R. Ruggiero, S. Dimopoulos, M. Raisch, D.W. Singhal, S. Carson, K. Obadina, E. Trifilio, S. West, D. Mehta, J. Bennett, C.L.

Abstract

More than half of all serious adverse reactions are identified 7 or more years after a drug receives approval from the US Food and Drug Administration (FDA). In 2002, 9 months after the intravenous bisphosphonate zoledronic acid received regulatory approval for marketing, the FDA received reports of nine patients with cancer, who were treated with zoledronic acid, who unexpectedly developed osteonecrosis of the jaw. During the next 2 years, three oral surgeons described 104 patients with cancer with osteonecrosis of the jaw in the medical literature and identified intravenous bisphosphonate therapy as being common to the care of these patients. In subspecialty medical, radiology, and dental journals, case reports and case series described clinical features of osteonecrosis of the jaw in patients with cancer who were treated with bisphosphonates. Manufacturer-sponsored epidemiological studies reported the first estimates of the incidence of this toxic effect, ranging from 0·1% to 1·8%. By contrast, independent epidemiological efforts from clinicians and the International Myeloma Foundation reported incidence estimates between 5% and 10%. Between 2003 and 2005, warnings about the risks of bisphosphonate-associated osteonecrosis were disseminated by national regulatory agencies, the manufacturers of bisphosphonates, and the International Myeloma Foundation. From 2006, independent clinical recommendations for diagnosis, prevention, and treatment of this toxic effect have been disseminated by manufacturers, national regulatory authorities, the International Myeloma Foundation, and medical specialty organisations. Furthermore, independent efforts by pharmaceutical manufacturers, dental and medical professionals, a non-profit organisation (the International Myeloma Foundation), patients, and regulatory authorities has led to the rapid identification and dissemination of safety information for this serious adverse reaction. Better coordination of safety-related pharmacovigilance initiatives is now needed. © 2008 Elsevier Ltd. All rights reserved.

Published
2008

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