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Your search keyword '"R, Otrusník"' showing total 2 results
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2 results on '"R, Otrusník"'

1. [Pharmaco-toxicologic evaluation of newly synthesized analogs of propafenone]

Author

I, Tumová, E, Racanská, J, Csöllei, G, Ecker, R, Otrusník, and P, Svec

Subjects
Propafenone, Guinea Pigs, Isoproterenol, Animals, Arrhythmias, Cardiac, Adrenergic beta-Agonists, Anesthetics, Local, Anti-Arrhythmia Agents
Abstract

The basic pharmacological evaluation of five analogues of propafenone was the aim of the present paper. Antiarrhythmic activity of the compounds at 10(-5) mol.kg-1 was established in guinea-pigs using experimental arrhythmias induced by ouabain and aconitine. The beta-adrenolytic efficiency of the compounds was studied in the isolated spontaneously beating guinea-pig atria and expressed as pA2 values against isoprenaline tachycardia. All of the compounds studied were local-anaesthetically active and their indexes of efficiency were 1-5 fold higher in comparison with the standards cocaine and procaine. The acute toxicity of the compounds was within acceptable limits.

Published
1997

2. [Pharmaco-toxicologic evaluation of newly synthesized analogs of propafenone].

Author

Tumová I, Racanská E, Csöllei J, Ecker G, Otrusník R, and Svec P

Subjects
Adrenergic beta-Agonists therapeutic use, Adrenergic beta-Agonists toxicity, Anesthetics, Local, Animals, Anti-Arrhythmia Agents toxicity, Arrhythmias, Cardiac chemically induced, Guinea Pigs, Isoproterenol, Propafenone therapeutic use, Propafenone toxicity, Anti-Arrhythmia Agents therapeutic use, Arrhythmias, Cardiac drug therapy, Propafenone analogs & derivatives
Abstract

The basic pharmacological evaluation of five analogues of propafenone was the aim of the present paper. Antiarrhythmic activity of the compounds at 10(-5) mol.kg-1 was established in guinea-pigs using experimental arrhythmias induced by ouabain and aconitine. The beta-adrenolytic efficiency of the compounds was studied in the isolated spontaneously beating guinea-pig atria and expressed as pA2 values against isoprenaline tachycardia. All of the compounds studied were local-anaesthetically active and their indexes of efficiency were 1-5 fold higher in comparison with the standards cocaine and procaine. The acute toxicity of the compounds was within acceptable limits.

Published
1997

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