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In order to analyse the peripheral disturbances repetitive stimulation test (RNS Test) and nerve conduction studies were done in 33 patients, 19 women and 14 men (mean age 38.2 years), with at least probable diagnosis of multiple sclerosis. In RNS Test the mean CMAP amplitude was significantly lower in comparison to the control group without any difference after 30 seconds of effort. Significant decrementing response was revealed at low rate of stimulation (2Hz) and incrementing response during tetanic stimulation. Significant lower mean amplitude of M wave in all investigated nerves was found in motor nerve conduction velocity test. Abnormal mean distal latency and motor conduction velocity were less common. The mean results of sensory conduction velocity test were similar to the control group.

In a group of patients with non-Hodgkin lymphoma axonal sensorimotor polyneuropathy was found in 15%. It appeared in the treated patients, those receiving doses of oncovin. Polyneuropathy was not correlated with the type of malignancy. Treatment seems to be the important factor which can cause polyneuropathy.

In a male patient multiple sclerosis was found to coexist with myasthenia. The symptoms of muscle fatiguability and of central nervous system damage developed at the same time. Multiple sclerosis was the predominating disease, especially in later stage of the disease. The authors discuss the possibility of a common immunological substrate for both conditions.

36 workers exposed to mercury vapour intoxication were examined to estimate the abnormalities in peripheral nervous system. 18 workers showed on physical examination features of polyneuropathy and in this group 15 workers had on emg examination sensory polyneuropathy. Statistical analysis was performed to show correlations between polyneuropathy on emg and age, time of exposure to mercury vapour and urinary mercury level. No such correlations were demonstrated.

A case of the Marinesco-Sjögren disease was diagnosed in a woman aged 19 years. In 5 out of 7 siblings cataract and/or nystagmus were found. On the ground of clinical analysis and literature data the classical form of the disease, abortive cases in the family and sporadic cases of the disease are distinguished. Attention is called to common features of the disease and Friedreich's disease and to the possibility of autosomal dominant inheritance, besides typical recessive inheritance of the MS disease.

The "transit time to cortex" was estimated in the group of 15 patients living around the copperworks. The somatosensory evoked potentials method has been applied. Clinical and neurographic disturbances (polyneuropathy with prolonged sensory conduction velocity) in this group of patients was accompanied by disturbances of the central nervous system ("transit time to cortex" was prolonged). The examination of averaged evoked potentials has a great value in estimation of early stages of toxic damages of the central nervous system and can be applied in the prevention of chronic industrial poisonings.

The 35 patients with bronchial asthma undergoing continuous steroid therapy were examined in order to reveal any signs of steroid myopathy. More than 80% of patients complained of muscle weakness. In the physical examination the motor function was correct in the majority of patients. Muscular enzymes and blood electrolytes were normal. EMG has shown typical myopathic changes In over 80% of patients. The diagnosis of subclinical steroid myopathy was based mainly on EMG examination. This myopathy was independent of sex, age, dose an duration of therapy.