26 results on '"R, Kohira"'
Search Results
2. [Brain lesion in congenital myotonic dystrophy]
- Author
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M, Haranaka, A, Endo, R, Kohira, Y, Fujita, M, Takada, O, Ohkubo, K, Harada, T, Kato, and S, Takashima
- Subjects
Male ,Asphyxia Neonatorum ,Hypoxia-Ischemia, Brain ,Infant, Newborn ,Brain ,Humans ,Infant ,Myotonic Dystrophy ,Cerebral Ventricles ,Dilatation, Pathologic - Abstract
Congenital myotonic dystrophy (CMyD) affects the brain, causing mental changes and psychomotor retardation. However, the pathophysiology of the brain dysfunctions in CMyD remain to be clarified. We described two cases of CMyD with brain abnormalities. Case 1 was diagnosed as having ventricular dilation at 17 days after birth, and died at 3 years and 6 months. Case 2 was diagnosed as having ventricular dilation at birth, and died at 1 year and 3 months. Pathologically, both cases showed remote hypoxic ischemic brain damage and leptomeningeal glioneuronal heterotopia (LGH). In our patients, the white matter changes may have been caused by perinatal asphyxia, and LGH by embryological abnormalities. Taken our data and those of previous reports together, it is suggested that cerebral abnormalities in CMyD are ascribed to both hypoxic ischemic changes and histogenetic abnormalities.
- Published
- 2000
3. [A case of multiple subdural empyema complicated by intracranial mycotic aneurysm]
- Author
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Y, Fujita, R, Kohira, K, Yanagida, I, Sugita, H, Shiihara, O, Ohkubo, and Y, Utsumi
- Subjects
Male ,Empyema, Subdural ,Adolescent ,Humans ,Intracranial Aneurysm ,Tomography, X-Ray Computed ,Aneurysm, Infected - Published
- 1987
4. A Combination Therapy for Kawasaki Disease with Severe Complications: a Case Report.
- Author
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Abe Y, Ayusawa M, Kawamura K, Yonezawa R, Kato M, Komori A, Kohira R, and Morioka I
- Abstract
Kawasaki disease (KD) is a form of acute multisystem vasculitis that presents with various complications, including coronary artery aneurysm. Heart failure and brain damage are rare, but life-threatening complications are associated with KD. Here, we describe a 4-year-old girl who developed intravenous immunoglobulin-resistant KD with both left ventricular failure and acute encephalopathy. On day 8 of the illness, the low left ventricular ejection fraction, mitral regurgitation, and low blood pressure, which required continuous administration of dobutamine, were observed during the treatments for KD, including intravenous immunoglobulin. She also appeared unconscious, where the electroencephalogram showed slow waves of activity in all regions of the brain. The cardiac performance improved after she received plasma exchange for three days. However, her unconsciousness with slow waves of activity on electroencephalogram and fever continued after the plasma exchange. Therefore, she was treated with methylprednisolone pulse, followed by prednisolone, as well as intravenous immunoglobulin. Finally, she recovered without any cardiac or neurological sequelae not only at the time she was discharged, but also throughout the follow-up period. The combination therapy using plasma exchange and methylprednisolone pulse may be a treatment option for severe KD with left ventricular failure and acute encephalopathy complications., Competing Interests: Conflict of interest: Authors state no conflict of interest in this report., (© 2020 Yuriko Abe et al., published by De Gruyter.)
- Published
- 2019
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5. Acute Focal Bacterial Nephritis Associated With Central Nervous System Manifestations: A Report of 2 Cases and Review of the Literature.
- Author
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Kasuga Y, Fuchigami T, Fukuda A, Takahashi S, Murai T, Yonezawa R, Miyashita M, Kohira R, Fujita Y, and Takahashi S
- Subjects
- Anti-Bacterial Agents therapeutic use, Bacterial Infections drug therapy, Brain Diseases drug therapy, Central Nervous System diagnostic imaging, Cerebrospinal Fluid chemistry, Cerebrospinal Fluid cytology, Child, Preschool, Diffusion Magnetic Resonance Imaging methods, Female, Humans, Nephritis diagnosis, Tomography, X-Ray Computed methods, Treatment Outcome, Bacterial Infections complications, Brain Diseases complications, Central Nervous System pathology, Encephalitis complications, Nephritis microbiology
- Abstract
Acute focal bacterial nephritis (AFBN) is a localized bacterial infection of the kidney presenting as an inflammatory mass without frank abscess formation. In children, most patients with AFBN present with nonspecific conditions, such as fever, vomiting, and abdominal pain. A small number of reported cases are accompanied by neurological symptoms, including meningeal irritation, unconsciousness, and seizures. We experienced 2 rare cases of AFBN associated with central nervous system lesions. The first case was a 3-year-old girl who had neurological symptoms, including unconsciousness and seizures, with AFBN associated with acute reversible encephalopathy. The second case was a 5-year-old girl who had neurological symptoms, including unconsciousness, with AFBN accompanied by clinically mild encephalitis/encephalopathy with a reversible splenial lesion.
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- 2017
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6. Severe Acute Subdural Hemorrhages in a Patient with Glutaric Acidemia Type 1 under Recommended Treatment.
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Ishige M, Fuchigami T, Ogawa E, Usui H, Kohira R, Watanabe Y, and Takahashi S
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- Amino Acid Metabolism, Inborn Errors complications, Amino Acid Metabolism, Inborn Errors diagnostic imaging, Brain Diseases, Metabolic complications, Brain Diseases, Metabolic diagnostic imaging, Craniocerebral Trauma complications, Craniocerebral Trauma diagnostic imaging, Hematoma, Subdural, Acute complications, Hematoma, Subdural, Acute diagnostic imaging, Humans, Infant, Male, Treatment Outcome, Amino Acid Metabolism, Inborn Errors surgery, Brain Diseases, Metabolic surgery, Craniocerebral Trauma surgery, Glutaryl-CoA Dehydrogenase deficiency, Hematoma, Subdural, Acute surgery, Severity of Illness Index
- Abstract
Glutaric acidemia type 1 is a rare autosomal recessive disease caused by a deficiency of glutaryl-CoA dehydrogenase. Previous studies have reported subdural hemorrhage in untreated patients with glutaric acidemia type 1. However, there is only one report of severe acute subdural hemorrhage after minor head trauma in a patient with glutaric acidemia type 1 under guideline-recommended treatment. We report a second case of life-threatening severe acute subdural hemorrhage after a minor head trauma in a patient with glutaric acidemia type 1. This patient was previously diagnosed by newborn screening, and treatment began at 25 days of age. Early diagnosis and guideline-recommended treatment produce better outcomes for patients with glutaric acidemia type 1, although the risk of subdural hemorrhage remains., (© 2016 S. Karger AG, Basel.)
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- 2017
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7. Affinity for music in Wolf-Hirschhorn syndrome: two case reports.
- Author
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Arakawa C, Fujita Y, Fuchigami T, Kawamura Y, Ishii W, Endo A, Kohira R, and Takahashi S
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- Adult, Child, Female, Humans, Music Therapy, Wolf-Hirschhorn Syndrome therapy, Young Adult, Music psychology, Wolf-Hirschhorn Syndrome psychology
- Abstract
Background: Wolf-Hirschhorn syndrome is a congenital malformation syndrome resulting from deletion of the short arm of chromosome 4. Individuals with Wolf-Hirschhorn syndrome may have a "Greek warrior helmet" appearance, growth retardation, developmental delay, muscular hypotonia, epilepsy, and difficulty with language including verbal communication. An affinity for music has not previously been reported in these patients., Patients: We describe two patients with Wolf-Hirschhorn syndrome who both have a strong affinity for music. One patient is a 20-year-old woman who likes to listen to music all day and can hum many tunes. The other patient is a 9-year-old girl who is calmed by music and received music therapy, with subsequent improvement in her communication skills (eye contact, joint attention, and vocalizations to request music)., Conclusions: Individuals with Wolf-Hirschhorn syndrome may have a strong affinity for music and may benefit from music therapy. Additional studies are needed to investigate the interest in music in individuals with Wolf-Hirschhorn syndrome., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
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8. A 3-year-old boy with Guillain-Barré syndrome and encephalitis associated with Mycoplasma pneumoniae infection.
- Author
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Hanzawa F, Fuchigami T, Ishii W, Nakajima S, Kawamura Y, Endo A, Arakawa C, Kohira R, Fujita Y, and Takahashi S
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- Child, Preschool, Humans, Male, Encephalitis microbiology, Guillain-Barre Syndrome microbiology, Pneumonia, Mycoplasma complications
- Abstract
Mycoplasma pneumoniae is a common cause of respiratory tract illness in children. Among the most common extrapulmonary manifestations are disorders of the central nervous system, including meningitis, meningoencephalitis, cerebellitis, polyneuropathy, acute disseminated encephalomyelitis, and Guillain-Barré syndrome. Guillain-Barré syndrome, also known as acute inflammatory demyelinating polyradiculoneuropathy, is an acute-onset, immune-mediated disorder of the peripheral nervous system. The central nervous system is usually intact in patients with Guillain-Barré syndrome. However, there have been some reports of an association of Guillain-Barré syndrome with central nervous system involvement in children. We report a 3-year-old boy with M. pneumoniae infection associated with Guillain-Barré syndrome and encephalitis. Both serum anti-GM1 ganglioside (IgG and IgM) and anti-galactocerebroside IgG antibodies were detected in our patient: the former in the earlier stage of the disease, and the latter in the later stage. We speculate that anti-GM1 ganglioside was associated more with encephalitis, and anti-galactocerebroside antibody was associated more with GBS in our case. Our patient is the youngest report of Guillain-Barré syndrome with central nervous system involvement, and the first report of a pediatric patient with associated M. pneumoniae infection. Such cases are rarely reported, but highlight the need for awareness of the association of the infection with Guillain-Barré syndrome with central nervous system involvement., (Copyright © 2013 Japanese Society of Chemotherapy and The Japanese Association for Infectious Disease. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2014
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9. [Clinical efficacy and pharmacokinetics of lamotrigine for childhood-onset intractable epilepsy].
- Author
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Ishii W, Fujita Y, Momoki E, Imai Y, Endo A, Arakawa C, Kohira R, Fuchigami T, and Mugishima H
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- Adolescent, Age of Onset, Child, Drug Therapy, Combination methods, Female, Humans, Lamotrigine, Male, Treatment Outcome, Triazines therapeutic use, Valproic Acid administration & dosage, Valproic Acid therapeutic use, Seizures drug therapy, Triazines pharmacokinetics
- Abstract
Objective: We investigated the clinical efficacy and pharmacokinetics of lamotrigine (LTG) as an add-on therapy in childhood-onset intractable epilepsy., Methods: We reviewed the charts of 28 outpatients who had received LTG as an add-on therapy. The data collected included epilepsy type, seizure frequency, concomitant anti-epileptic drugs, dosage of LTG and LTG serum levels. Furthermore, we reviewed the relationship between the LTG serum levels (microg/ml) and dosage of LTG (mg/kg/day), as well as the relationship between the LTG serum levels (microg/ml) and clinical efficacy in the following 2 groups:the valproate sodium (VPA) combination group and the non-VPA combination group., Results: A reduction of 50% or more in seizure frequency was observed in 10 patients. In addition, there was a high correlation between the LTG serum levels and the dosage of LTG in each group. In the VPA combination group, the average of LTG serum levels in patients with adequate therapeutic response (50% reduction in seizure frequency) was higher than that in patients without adequate therapeutic response. In the non-VPA combination group, the average LTG serum level in adequate response patients was lower than that in patients without adequate therapeutic response. However, the epilepsy types of adequate response patients differed in the two groups., Conclusions: The LTG serum level is predictable based on the dosage of LTG. It was judged that the effective blood concentration of LTG differed when used with VPA, although factors other than the combined use of VPA should have been taken into consideration also.
- Published
- 2014
10. Acute encephalopathy with pandemic (H1N1) 2009 virus infection.
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Fuchigami T, Imai Y, Hasegawa M, Ishii W, Endo A, Arakawa C, Kohira R, Hashimoto K, Fujita Y, Inamo Y, and Mugishima H
- Subjects
- Child, Child, Preschool, DNA, Viral analysis, Electroencephalography, Encephalitis, Viral diagnosis, Encephalitis, Viral virology, Female, Humans, Influenza, Human epidemiology, Influenza, Human virology, Japan epidemiology, Magnetic Resonance Imaging, Male, Retrospective Studies, Tomography, X-Ray Computed, Encephalitis, Viral epidemiology, Influenza A Virus, H1N1 Subtype genetics, Influenza, Human complications, Pandemics
- Abstract
Objectives: In April 2009, a novel influenza A (H1N1) pdm virus was identified in Mexico and spread quickly around the world. However, the clinical features of acute encephalopathy associated with 2009 pandemic influenza have not yet been elucidated., Methods: We treated 8 patients (3 boys and 5 girls) aged 4 to 11 years (average age, 8 y 3 months) with influenza virus-associated encephalopathy, who presented at our 2 hospitals between July 2009 and March 2010. We investigated the clinical characteristics, treatments, and outcomes in the patients., Results: In all patients, brain computed tomography showed mild to severe diffuse cerebral edema, and electroencephalography revealed diffuse high-voltage slow waves. They were all treated with oseltamivir and methylprednisolone pulse therapy. Six patients recovered without any sequelae; however, the remaining 2 had residual neurological sequelae. These 2 patients presented with severe disturbance of consciousness, and their central nervous system symptoms appeared within 12 hours after the onset of fever. One patient had periventricular leukomalacia and symptomatic epilepsy by perinatal brain hypoxia, and the other patient had 1 complex febrile and 2 febrile seizures., Conclusions: This study showed that patients with influenza-associated encephalopathy caused by influenza A (H1N1) pdm infection were all older than those with seasonal influenza. Underlying neurological disease or history may be associated with poor prognosis.
- Published
- 2012
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11. Liver-specific mitochondrial respiratory chain complex I deficiency in fatal influenza encephalopathy.
- Author
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Arakawa C, Endo A, Kohira R, Fujita Y, Fuchigami T, Mugishima H, Ohtake A, Murayama K, Mori M, Miyata R, and Hatai Y
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- Child, Preschool, Electron Transport Complex I deficiency, Electron Transport Complex I metabolism, Humans, Male, Electron Transport Complex IV metabolism, Encephalitis Viruses pathogenicity, Influenza, Human complications, Liver enzymology, Mitochondrial Diseases complications, Mitochondrial Diseases metabolism, Mitochondrial Diseases pathology
- Abstract
We report on a 4-year-old boy who died from influenza encephalopathy. The clinical course and microscopic findings of the autopsied liver were compatible with Reye's syndrome. We examined the mitochondrial respiratory chain function by blue native polyacrylamide gel electrophoresis (BN-PAGE), western blotting, and respiratory chain enzyme activity assays. The activity of liver respiratory chain complex (CO) I was markedly decreased (7.2% of the respective control activity); whereas, the other respiratory chain complex activities were substantially normal (CO II, 57.9%; CO III, 122.3%; CO IV, 161.0%). The activities of CO I-IV in fibroblasts were normal (CO I, 82.0%; CO II, 83.1%; CO III, 72.9%; CO IV, 97.3%). The patient was diagnosed with liver-specific complex I deficiency. This inborn disorder may have contributed to the fatal outcome. We propose that relying only on fibroblast respiratory chain complex activities may lead to the misdiagnosis of liver-specific complex I deficiency., (Copyright © 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.)
- Published
- 2012
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12. Tipepidine hibenzate intoxication.
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Imai Y, Ishii W, Endo A, Arakawa C, Kohira R, Fujita Y, Fuchigami T, and Mugishima H
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- Child, Preschool, Drug Overdose, Humans, Male, Antitussive Agents poisoning, Delirium chemically induced, Piperidines poisoning
- Published
- 2011
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13. Improvement of intractable childhood epilepsy following acute viral infection.
- Author
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Fujita Y, Imai Y, Ishii W, Endo A, Arakawa C, Kohira R, Fuchigami T, Okubo O, and Mugishima H
- Subjects
- Acute Disease, Child, Preschool, Electroencephalography, Epilepsies, Myoclonic physiopathology, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Spasms, Infantile physiopathology, Virus Diseases virology, Epilepsies, Myoclonic drug therapy, Epilepsies, Myoclonic etiology, Spasms, Infantile drug therapy, Spasms, Infantile etiology, Virus Diseases complications
- Abstract
In this study, we report 11 patients with intractable childhood epilepsy that improved following acute viral infection. The patients were 8 boys and 3 girls. Six of the 11 children were diagnosed as West syndrome (5 of the symptomatic type and 1 of the cryptogenic type). The remaining 5 children were myoclonic seizures. The patients became seizure free within 6 days following acute viral infections without an exchange or addition of antiepileptic drugs (AEDs). The types of acute viral infections were Exanthema subitum (Roseola infantum) in 5 patients, Rotavirus gastroenteritis in 2 patients, Measles infection in 2 patients, Herpetic stomatitis in 1 patient and Common cold in the remaining patient. Salaam seizures and/or tonic spasms disappeared within 6 days after the onset of viral infections, and hypsarrhythmia evolved to localized spikes on electroencephalography (EEG) in the patients with West syndrome. Epileptic seizures disappeared rapidly and EEG gradually normalized or improved in patients with myoclonic seizures. Four patients became seizure free for 5 years to 20 years. In 6 patients, seizures relapsed within 14 days to 1 month after the disappearance of seizures. One child remained seizure free for 12 months after viral infection. Common factors in 4 children who were continuously seizure free include (1) normal or almost normal findings of brain CT/MRI, (2) normal development prior to the onset of epileptic seizures, and (3) a short time interval between the onset of seizures and the acute viral infection. We propose several hypotheses including an immunological effect for the improvement of intractable childhood epilepsy following acute viral infection. Further study may provide important information concerning the mechanism of seizure control and the applicable to treatment for intractable childhood epilepsy., (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Published
- 2011
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14. Detection of group a rotavirus RNA and antigens in serum and cerebrospinal fluid from two children with clinically mild encephalopathy with a reversible splenial lesion.
- Author
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Arakawa C, Fujita Y, Imai Y, Ishii W, Kohira R, Fuchigami T, Mugishima H, Izumi H, and Kuzuya M
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- Antigens, Antigens, Viral genetics, Antigens, Viral immunology, Brain pathology, Brain physiopathology, Capsid Proteins genetics, Capsid Proteins immunology, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Feces virology, Humans, Male, Reverse Transcriptase Polymerase Chain Reaction, Rotavirus Infections pathology, Rotavirus Infections virology, Antigens, Viral analysis, Cerebrospinal Fluid virology, RNA, Viral analysis, Rotavirus isolation & purification, Rotavirus Infections diagnosis, Serum virology
- Abstract
We report on two children with mild encephalopathy with a reversible splenial lesion associated with group A rotavirus (GARV) infection. We examined stool, serum, and cerebrospinal fluid samples to determine the presence of the GARV VP7 gene and GARV antigen by reverse-transcription PCR and enzyme-linked immunosorbent assay, respectively. GARV antigen was detected in stool samples from both patients. The GARV G genotype was G9 in one child and G3 in the other. GARV antigens were also found in both serum samples. However, the GARV VP7 gene was detected in only one serum sample, which was collected on the first day of symptomatic illness. Neither GARV antigen nor the VP7 gene was detected in cerebrospinal fluid samples. Both patients had excellent outcomes. Our results suggest that the reversible splenial changes in our patients might have been caused by indirect effects to the central nervous system subsequent to viral infection.
- Published
- 2011
15. A case of D-lactic acid encephalopathy associated with use of probiotics.
- Author
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Munakata S, Arakawa C, Kohira R, Fujita Y, Fuchigami T, and Mugishima H
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- Child, Preschool, Female, Humans, Neurotoxicity Syndromes physiopathology, Acidosis, Lactic complications, Acidosis, Lactic etiology, Neurotoxicity Syndromes etiology, Probiotics adverse effects, Short Bowel Syndrome complications
- Abstract
A five year old girl was admitted to the hospital for evaluation of intermittent ataxia. She had undergone serial resections of the small intestine after birth, resulting in short bowel syndrome. Lactomin was prescribed for watery diarrhea at twice the regular dose 2 weeks before the onset of neurologic symptoms. D-lactic acidosis was diagnosed on the basis of a plasma D-lactate level of 5.537 mmol/l. Lactomin was discontinued, and she was treated with sodium bicarbonate and oral antibiotics. The probiotics the patient had taken were likely the cause of D-lactic acidosis and should therefore be avoided in patients with short bowel syndrome., (Copyright 2009 Elsevier B.V. All rights reserved.)
- Published
- 2010
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16. Rotavirus antigenemia and genomia in children with rotavirus gastroenteritis.
- Author
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Fujita Y, Liu B, Kohira R, Fuchigami T, Mugishima H, Izumi H, Kuzuya M, Fujii R, Hamano M, and Ogura H
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- Antigens, Viral genetics, Capsid Proteins genetics, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Feces virology, Female, Humans, Infant, Male, Reverse Transcriptase Polymerase Chain Reaction, Rotavirus genetics, Rotavirus immunology, Viral Nonstructural Proteins genetics, Antigens, Viral blood, Blood virology, Gastroenteritis virology, RNA, Viral blood, Rotavirus isolation & purification, Rotavirus Infections virology
- Abstract
We investigated group A rotavirus (GARV) antigenemia and genomia in children with rotavirus gastroenteritis. A total of 16 patients (2-29 months old), who received a diagnosis of GARV gastroenteritis using a commercial rapid test, were enrolled in this study. The sera from the patients were tested for the presence of GARV antigen and the VP7 and NSP3 genes using an enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction, respectively. Furthermore, when the VP7 gene was amplified, G type was identified and compared with that of GARV from the fecal samples of the patients. GARV antigen was detected in 12 of 16 serum samples (75.0%). No GARV antigen was found in infants that were 6 months old or younger. Thirteen of 16 serum samples (81.3%) were positive for GARV genes. In cases where both antigen and gene analyses were conducted, either GARV antigens or genes, or both, were detected in all cases. The GARV antigen levels of serum collected at 2 days of illness or more were significantly higher than were the levels in the samples obtained from the 1st day. Furthermore, the ELISA optical density values of patients with convulsion were significantly higher than were those of patients without convulsion, suggesting that the antigen level is associated with disease severity.
- Published
- 2010
17. Event-related potentials in response to 3-D auditory stimuli.
- Author
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Fuchigami T, Okubo O, Fujita Y, Kohira R, Arakawa C, Endo A, Haruyama W, Imai Y, and Mugishima H
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- Acoustic Stimulation, Adolescent, Adolescent Development, Adult, Age Factors, Child, Child Development, Child, Preschool, Doppler Effect, Electroencephalography, Female, Humans, Male, Reaction Time, Regression Analysis, Event-Related Potentials, P300 physiology, Evoked Potentials, Auditory physiology, Sound Localization physiology
- Abstract
To evaluate auditory spatial cognitive function, age correlations for event-related potentials (ERPs) in response to auditory stimuli with a Doppler effect were studied in normal children. A sound with a Doppler effect is perceived as a moving audio image. A total of 99 normal subjects (age range, 4-21 years) were tested. In the task-relevant oddball paradigm, P300 and key-press reaction time were elicited using auditory stimuli (1000 Hz fixed and enlarged tones with a Doppler effect). From the age of 4 years, the P300 latency for the enlarged tone with a Doppler effect shortened more rapidly with age than did the P300 latency for tone-pips, and the latencies for the different conditions became similar towards the late teens. The P300 of auditory stimuli with a Doppler effect may be used to evaluate auditory spatial cognitive function in children.
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- 2009
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18. Detection of rotavirus RNA and antigens in serum and cerebrospinal fluid samples from diarrheic children with seizures.
- Author
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Liu B, Fujita Y, Arakawa C, Kohira R, Fuchigami T, Mugishima H, and Kuzuya M
- Subjects
- Antigens, Viral genetics, Capsid Proteins genetics, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Feces virology, Female, Genotype, Humans, Infant, Male, Reverse Transcriptase Polymerase Chain Reaction, Rotavirus genetics, Rotavirus immunology, Antigens, Viral blood, Antigens, Viral cerebrospinal fluid, Diarrhea etiology, RNA, Viral blood, RNA, Viral cerebrospinal fluid, Rotavirus isolation & purification, Rotavirus Infections complications, Seizures etiology
- Abstract
Group A rotavirus (GARV) genes (the VP7 and NSP3 genes) in acute-phase cerebrospinal fluid (CSF), sera and stool samples from 6 children with convulsions accompanied by GARV gastroenteritis were investigated by reverse transcription-polymerase chain reaction (RT-PCR). When the VP7 gene was amplified from the samples, the G genotype (G type) of GARV was determined by RT-PCR. GARV genes were detected in the CSF samples of all 6 children, in 2 of the 3 blood samples, and in all of 4 stool samples. The G typing of GARV from 12 of a total of 13 samples indicated that G3 was the predominant G type in all samples. GARV antigens were detected by enzyme-linked immunosorbent assay in all of the 3 tested sera samples, while no GARV antigens were detected in any of the 5 tested CSF samples. We confirmed the presence of GARV genomes in the CSF samples from all of the children with rotavirus-associated seizures, including encephalopathy. However, the relationship between convulsions and the existence of GARV RNA in CSF remains unclear and further study is required.
- Published
- 2009
19. [A case of rhabdomyolysis associated with Salmonella encephalopathy].
- Author
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Miyabayashi H, Yamamori H, Nishimura A, Kohira R, Fujita Y, Okubo O, and Harada K
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- Acute Kidney Injury etiology, Acute Kidney Injury therapy, Brain Diseases complications, Brain Edema complications, Child, Preschool, Female, Humans, Prognosis, Brain Diseases microbiology, Rhabdomyolysis etiology, Salmonella Infections complications
- Abstract
We report a case of severe rhabdomyolysis associated with Salmonella encephalopathy. A 3-year-old girl was admitted to our hospital because of status convulsives and unconsciousness. She was diagnosed as having Salmonella encephalopathy with rhabdmyolysis, and was treated by mild hypothermia and mechanical ventilation. Five days later she developed anuria with increased serum levels of myoglobin, CK and creatinine. And the diagnosis of acute renal failure was made. Peritoneal dialysis was begun from 6 days after admission. Hyperinfusion, the usual therapy of rhabdomyolysis, was not performed. She survived showing gradual improvement of renal function and consciousness. In a case of rhabdomyolysis complicating a neurologic disorder, a well-known poor prognostic factor, priority should be given to brain protection rather than to symptomatic treatment of rhabdomyolysis.
- Published
- 2002
20. [Hopkins syndrome: oral prednisolone was effective for the paralysis].
- Author
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Nakano Y, Kohira R, Yamazaki H, Fujita N, Fuchigami T, Okubo O, and Harada K
- Subjects
- Child, Preschool, Female, Humans, Paralysis complications, Syndrome, Anti-Inflammatory Agents administration & dosage, Asthma complications, Paralysis drug therapy, Poliomyelitis complications, Prednisolone administration & dosage
- Abstract
We describe here a 5-year-old girl who presented flaccid paralysis of the left upper limb after recovery from bronchial asthma. T2-weighted magnetic resonance imaging of the cervical cord revealed a focal high intensity area in the left anterior horn at the C6-C7 level. She was treated with oral prednisolone, and paralysis resolved within two months. Thirty cases of Hopkins syndrome have been reported so far, but its cause remains unknown. Early administration of prednisolone might ameliorate paralysis in this syndrome.
- Published
- 2001
21. [Brain lesion in congenital myotonic dystrophy].
- Author
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Haranaka M, Endo A, Kohira R, Fujita Y, Takada M, Ohkubo O, Harada K, Kato T, and Takashima S
- Subjects
- Asphyxia Neonatorum complications, Brain pathology, Cerebral Ventricles pathology, Dilatation, Pathologic etiology, Dilatation, Pathologic pathology, Humans, Hypoxia-Ischemia, Brain etiology, Hypoxia-Ischemia, Brain pathology, Infant, Infant, Newborn, Male, Myotonic Dystrophy complications, Myotonic Dystrophy pathology
- Abstract
Congenital myotonic dystrophy (CMyD) affects the brain, causing mental changes and psychomotor retardation. However, the pathophysiology of the brain dysfunctions in CMyD remain to be clarified. We described two cases of CMyD with brain abnormalities. Case 1 was diagnosed as having ventricular dilation at 17 days after birth, and died at 3 years and 6 months. Case 2 was diagnosed as having ventricular dilation at birth, and died at 1 year and 3 months. Pathologically, both cases showed remote hypoxic ischemic brain damage and leptomeningeal glioneuronal heterotopia (LGH). In our patients, the white matter changes may have been caused by perinatal asphyxia, and LGH by embryological abnormalities. Taken our data and those of previous reports together, it is suggested that cerebral abnormalities in CMyD are ascribed to both hypoxic ischemic changes and histogenetic abnormalities.
- Published
- 2000
22. Magnetic resonance imaging of the cauda equina in two patients with Guillain-Barré syndrome.
- Author
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Fuchigami T, Iwata F, Noguchi Y, Kohira R, Yamazaki H, Okubo O, Utsumi Y, and Harada K
- Subjects
- Child, Child, Preschool, Female, Humans, Spinal Nerve Roots pathology, Cauda Equina pathology, Magnetic Resonance Imaging, Polyradiculoneuropathy diagnosis
- Abstract
The results are presented of magnetic resonance imaging (MRI) of the spine in two cases of childhood Guillain-Barré syndrome. After injection of gadolinium-diethylenetriamine pentaacetic acid, MRI showed enhancement of the cauda equina in these patients. These MRI observations may help confirm the diagnosis of Guillain-Barré syndrome. The nerve root enhancement resolved as the clinical symptoms improved. Serial imaging may be useful in monitoring the response to therapy and assessing new treatment regimens. It may also yield a better understanding of the disease process.
- Published
- 1997
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23. Dissociation between upper and lower neck N13 potentials following paired median nerve stimuli.
- Author
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Araki A, Yamada T, Ito T, Urushibara N, Kohira R, Hsu SP, and Yeh M
- Subjects
- Adult, Electroencephalography, Electromyography, Humans, Male, Evoked Potentials, Somatosensory physiology, Median Nerve physiology, Neck physiology
- Abstract
Cervical N13 potential in response to the median nerve stimulation can be recorded either from upper (Cv2) or lower (Cv6) neck with almost equal amplitudes and latencies. It has long been debated whether they represent the same or different generator sources. Using a conditioning-test paired stimuli paradigm, we examined the differences of recovery function of Cv2- and Cv6-N13, anterior neck (AN)-P13, and scalp recorded P13/P14 in 6 healthy subjects. All cervical electrodes were referenced to the non-cephalic site. Scalp response was recorded with linked ear reference. The inter-stimulus intervals ranged from 4 to 20 ms with 2 ms increments. Throughout 4 to 18 ms ISI, Cv6-N13, AN-P13 and scalp P13/P14 were suppressed, whereas Cv2-N13 was facilitated. All but scalp P13/P14 returned close to the control at 20 ms ISI. The findings indicate that Cv2-N13, Cv6-N13 and scalp P13/P14 are independent each other and arise from different generator sources. The suppression of Cv6-N13 is consistent with a postsynaptic nature of this potential and may indeed be mediated through dorsal horn interneurons creating a current field orientation in the posterior-anterior direction. The facilitation of Cv2-N13 suggests that this is a presynaptic potential and may travel through the dorsal column with vertical orientation. The longer period of suppression of scalp P13/P14 suggests it to be of polysynaptic origin and to arise at least rostral to the cuneate nucleus.
- Published
- 1997
- Full Text
- View/download PDF
24. Developmental changes in P300 wave elicited during two different experimental conditions.
- Author
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Fuchigami T, Okubo O, Ejiri K, Fujita Y, Kohira R, Noguchi Y, Fuchigami S, Hiyoshi K, Nishimura A, and Harada K
- Subjects
- Adolescent, Adult, Cerebral Cortex physiology, Child, Child, Preschool, Evoked Potentials, Auditory physiology, Female, Humans, Male, Reaction Time physiology, Reference Values, Attention physiology, Child Development physiology, Event-Related Potentials, P300 physiology
- Abstract
Age-related correlations on auditory event-related potentials were studied using a task-relevant oddball paradigm in 175 normal subjects aged 4-21 years and age-related correlations in the "ignore" condition were studied in 108 normal subjects aged 1-21 years. In the ignore condition, subjects more than 4 years of age were instructed to read a book to divert attention from the auditory stimulus. From 4 to about 17 years of age, the latencies of task-relevant P300 in event-related potentials (ERPs) gradually shortened. In the ignore condition experiment, the P300 latency shortened progressively, but stabilized at about 12 years of age. Whereas P300 in the ignore condition likely corresponds to P3a described previously (passive attention), the conventional P300 wave corresponds to P3b (active attention). The findings indicate a developmental difference between the P3a and P3b potential.
- Published
- 1995
- Full Text
- View/download PDF
25. Neonatal glutamate can destroy the hippocampal CA1 structure and impair discrimination learning in rats.
- Author
-
Kubo T, Kohira R, Okano T, and Ishikawa K
- Subjects
- Animals, Animals, Newborn, Dose-Response Relationship, Drug, Excitatory Amino Acid Antagonists, Frontal Lobe drug effects, Frontal Lobe pathology, Glutamates pharmacology, Hippocampus pathology, Hippocampus physiology, Organ Specificity, Pyramidal Tracts pathology, Pyramidal Tracts physiology, Rats, Rats, Wistar, Discrimination Learning drug effects, Hippocampus drug effects, Neurotoxins toxicity, Pyramidal Tracts drug effects, Sodium Glutamate toxicity
- Abstract
Neonatal Wistar rats were subcutaneously injected with 0.1, 1, or 2 mg/g b.wt. of monosodium glutamate (MSG) at 1, 3, 5, 7, and 9 days after birth. The animals were observed for degeneration of pyramidal cells in the hippocampus. The histological change disappeared when the animals were concurrently injected with glutamate diethyl ester (GDEE), an antagonist of the glutamate receptor. When light-dark discrimination learning was carried out at 10 weeks old, the correct response in the acquisition period was impaired in the animals given 1 and 2 mg/g of neonatal MSG. Their retention scores were also impaired in comparison with the control animal. The behavioral impairment recovered with pre-treatment with GDEE. No significant changes were observed in the concentrations of transmitter substances, including amino acids and monoamines. These results suggest that neonatal MSG destroys the hippocampus and impairs acquisition and retention of discrimination learning through the mechanism of glutamate receptors.
- Published
- 1993
- Full Text
- View/download PDF
26. [A case of multiple subdural empyema complicated by intracranial mycotic aneurysm].
- Author
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Fujita Y, Kohira R, Yanagida K, Sugita I, Shiihara H, Ohkubo O, and Utsumi Y
- Subjects
- Adolescent, Empyema, Subdural diagnostic imaging, Humans, Male, Tomography, X-Ray Computed, Aneurysm, Infected etiology, Empyema, Subdural complications, Intracranial Aneurysm etiology
- Published
- 1987
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