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2 results on '"R, Blagoevich"'

1. [Patterns in the binding of cytotoxic neuropharmacologic preparations by early sea urchin embryos]

Author

B N, Manukhin, G A, Buznikov, T M, Turpaev, L, Rakich, and R, Blagoevich

Subjects
Psychotropic Drugs, Binding Sites, Embryo, Nonmammalian, Sea Urchins, Animals, Serotonin Antagonists
Abstract

Early embryos of Arbacia lixula, Paracentrotus lividus and Sphaerechinus granularis intensively bind cytotoxic neuropharmacological drugs, such as antiserotonine indole derivatives, cholinolytics and tricyclic antidepressants. The binding intensity decreases markedly upon quaternization of the drugs. Quantitative analysis indicates that: a)with respect to the drugs, the suspension of living embryos may be described as a single adsorbing system following the Langmuir equation; b) at least two independent binding pools exist in embryos; c) the magnitude of cytotoxic effect of a given drug is not proportional to its binding.

Published
1976

2. [Patterns in the binding of cytotoxic neuropharmacologic preparations by early sea urchin embryos].

Author

Manukhin BN, Buznikov GA, Turpaev TM, Rakich L, and Blagoevich R

Subjects
Animals, Binding Sites, Sea Urchins, Serotonin Antagonists, Embryo, Nonmammalian metabolism, Psychotropic Drugs metabolism
Abstract

Early embryos of Arbacia lixula, Paracentrotus lividus and Sphaerechinus granularis intensively bind cytotoxic neuropharmacological drugs, such as antiserotonine indole derivatives, cholinolytics and tricyclic antidepressants. The binding intensity decreases markedly upon quaternization of the drugs. Quantitative analysis indicates that: a)with respect to the drugs, the suspension of living embryos may be described as a single adsorbing system following the Langmuir equation; b) at least two independent binding pools exist in embryos; c) the magnitude of cytotoxic effect of a given drug is not proportional to its binding.

Published
1976

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