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12 results on '"Quraishi, Marzuqa"'

4. Identification of a Novel HIV‐1 Integrase Strand Transfer Inhibitor: A Synergistic Approach Combining Pharmacophore Modelling and In Vitro Assays.

Author

Sayyed, Sharif Karim, Quraishi, Marzuqa, Jobby, Renitta, Rameshkumar, Neelamegam, Sonawane, Tareeka, and Ravichandran, Vinothkannan

Abstract

Background: AIDS is a highly prevalent and life‐threatening global epidemic that severely compromises the host's immune system, increasing vulnerability to opportunistic diseases. The absence of definitive curative drugs emphasizes the importance and necessity of discovering novel anti‐HIV agents. Objective: This study aims to discover a natural molecular entity that acts as an Integrase strand transfer inhibitor (INSTI) with enhanced potency against HIV. Methods: A ligand‐based pharmacophore model was developed for 4 FDA‐approved INSTIs, with the potential for treating HIV‐1. AutoDock facilitated molecular docking and free energy calculation to discern IN activity. Subsequently, MD simulations assessed interaction stability. ADMET analysis preceded an in vitro anti‐HIV strand transfer assay. Results: The generated model revealed a specific interaction involving Mg2+ ion chelation. Crucial residues of HIV‐1 IN and their respective free‐binding energies were identified. The lead compound exhibited superior in silico characteristics which were substantiated by 100 ns MD simulations and MM‐PBSA analysis. Additionally, the in vitro assay demonstrated potent inhibition with the lowest IC50, forming strong molecular interactions with IN. Conclusion: These findings showed valuable insights for the strategic development of new antiretroviral treatments (ART), paving the path for the development of natural therapeutic agents for HIV treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Contributors

Author

Agasam, Tanmai, primary, Aware, Chetan, additional, Bansal, Megha, additional, Bharadwaj, Tushar, additional, Chamundeeswari, M., additional, Chandra, Ram, additional, Chandrashekharaiah, P.S., additional, Charan, P.D., additional, Chitra, J., additional, Dange, Pooja, additional, Danquah, Michael K., additional, Das, Jayashankar, additional, Dasgupta, Santanu, additional, Dash, Stiti Prangya, additional, Dave, Shivani, additional, Dave, Sushma, additional, Desai, Dishant, additional, Deshmukh, Rehan, additional, Dutta, Kasturi, additional, Dwivedi, Vinay, additional, Gadnayak, Ayushman, additional, Gopal Samy, B., additional, Gupta, Piyush K., additional, Hansdah, Rukmani, additional, Jadhav, Jyoti, additional, Jagtap, Sharmili, additional, Jeba Mercy, J., additional, Jeevanandam, Jaison, additional, Jeyakanthan, J., additional, Kar, Abhipsa, additional, Khalifa, Ashraf Y.Z., additional, Kodgire, Santosh, additional, Kothari, Richa, additional, Kumar, Adarsh, additional, Kumar, Saroj, additional, Mahendran, G., additional, Manikandan, N., additional, Meghwanshi, Gautam Kumar, additional, Mohanty, Jatindra Nath, additional, Mohanty, Padmaja, additional, Mohapatra, Madhusmita, additional, Nabil, R., additional, Nayak, Ananya, additional, Nigam, Vinod Kumar, additional, Pan, Sharadwata, additional, Pandit, Soumya, additional, Prasad, Dinesh, additional, Prasad, Jay Kishor, additional, Prasanna Kumari, N.K., additional, Purohit, Praveen, additional, Quraishi, Marzuqa, additional, Raghuwanshi, Richa, additional, Raina, Shubham, additional, Rajendren, S., additional, Rastogi, Gurdeep, additional, Rawat, Shruti, additional, Roy, Ayush Singha, additional, Sagaram, Uma Shankar, additional, Sahoo, Maheswata, additional, Sahoo, Swayamprabha, additional, Sampath, Muthu Kumar, additional, Sankaranarayanan, A., additional, Sanyal, Debanjan, additional, Sarkar, Angana, additional, Sarkar, Debapriya, additional, Sarkar, Pradip, additional, Savitha, T., additional, Savlab, Nishit, additional, Saxena, Nishant, additional, Shah, Masirah Zahid, additional, Sharma, Abhishek, additional, Sharma, Jai Gopal, additional, Singh, Ajay Kumar, additional, Singh, Har Mohan, additional, Singh, Sangeeta, additional, Singh, Sunita, additional, Sonkamble, Varsha Vasantrao, additional, Srivastava, Pulkit, additional, Tamilarasan, K., additional, Tiwari, Neha, additional, Tyagi, V.V., additional, Vashishtha, Abhishek, additional, Wagh, Nilesh Shirish, additional, Wagh, Prashant Rajesh, additional, and Yadav, Anjali, additional

Published
2022
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9. Valorisation of CO2 into Value-Added Products via Microbial Electrosynthesis (MES) and Electro-Fermentation Technology

Author

Quraishi, Marzuqa, primary, Wani, Kayinath, additional, Pandit, Soumya, additional, Gupta, Piyush Kumar, additional, Rai, Ashutosh Kumar, additional, Lahiri, Dibyajit, additional, Jadhav, Dipak A., additional, Ray, Rina Rani, additional, Jung, Sokhee P., additional, Thakur, Vijay Kumar, additional, and Prasad, Ram, additional

Published
2021
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11. Exploiting microbes in the petroleum field : Analyzing the credibility of microbial enhanced oil recovery (MEOR)

Author

Quraishi, Marzuqa, Bhatia, Shashi Kant, Pandit, Soumya, Gupta, Piyush Kumar, Rangarajan, Vivek, Lahiri, Dibyajit, Varjani, Sunita, Mehariya, Sanjeet, Yang, Yung-Hun, Quraishi, Marzuqa, Bhatia, Shashi Kant, Pandit, Soumya, Gupta, Piyush Kumar, Rangarajan, Vivek, Lahiri, Dibyajit, Varjani, Sunita, Mehariya, Sanjeet, and Yang, Yung-Hun

Abstract

Crude oil is a major energy source that is exploited globally to achieve economic growth. To meet the growing demands for oil, in an environment of stringent environmental regulations and economic and technical pressure, industries have been required to develop novel oil salvaging techniques. The remaining ~70% of the world’s conventional oil (one-third of the available total petroleum) is trapped in depleted and marginal reservoirs, and could thus be potentially recovered and used. The only means of extracting this oil is via microbial enhanced oil recovery (MEOR). This tertiary oil recovery method employs indigenous microorganisms and their metabolic products to enhance oil mobilization. Although a significant amount of research has been undertaken on MEOR, the absence of convincing evidence has contributed to the petroleum industry’s low interest, as evidenced by the issuance of 400+ patents on MEOR that have not been accepted by this sector. The majority of the world’s MEOR field trials are briefly described in this review. However, the presented research fails to provide valid verification that the microbial system has the potential to address the identified constraints. Rather than promising certainty, MEOR will persist as an unverified concept unless further research and investigations are carried out.

Published
2021
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12. Valorisation of CO2 into Value-Added Products via Microbial Electrosynthesis (MES) and Electro-Fermentation Technology.

Author

Quraishi, Marzuqa, Wani, Kayinath, Pandit, Soumya, Gupta, Piyush Kumar, Rai, Ashutosh Kumar, Lahiri, Dibyajit, Jadhav, Dipak A., Ray, Rina Rani, Jung, Sokhee P., Thakur, Vijay Kumar, and Prasad, Ram

Subjects
ELECTROSYNTHESIS, MICROBIAL products, MICROBIAL fuel cells, GREENHOUSE effect, INORGANIC compounds, ELECTROCATALYSIS, ELECTRODE reactions
Abstract

Microbial electrocatalysis reckons on microbes as catalysts for reactions occurring at electrodes. Microbial fuel cells and microbial electrolysis cells are well-known in this context; both prefer the oxidation of organic and inorganic matter for producing electricity. Notably, the synthesis of high energy-density chemicals (fuels) or their precursors by microorganisms using biocathode to yield electrical energy is called Microbial Electrosynthesis (MES), giving an exceptionally appealing novel way for producing beneficial products from electricity and wastewater. This review accentuates the concept, importance and opportunities of MES, as an emerging discipline at the nexus of microbiology and electrochemistry. Production of organic compounds from MES is considered as an effective technique for the generation of various beneficial reduced end-products (like acetate and butyrate) as well as in reducing the load of CO2 from the atmosphere to mitigate the harmful effect of greenhouse gases in global warming. Although MES is still an emerging technology, this method is not thoroughly known. The authors have focused on MES, as it is the next transformative, viable alternative technology to decrease the repercussions of surplus carbon dioxide in the environment along with conserving energy. [ABSTRACT FROM AUTHOR]

Published
2021
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