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304 results on '"Quitadamo, P."'

1. Potential of RES-NOVA as Dark Matter observatory

Author

Alloni, D., Benato, G., Carniti, P., Cataldo, M., Chen, L., Clemenza, M., Consonni, M., Croci, G., Dafinei, I., Danevich, F. A., Di Martino, D., Di Stefano, E., Iachellini, N. Ferreiro, Ferroni, F., Filippini, F., Ghislandi, S., Giachero, A., Gironi, L., Gorla, P., Gotti, C., Helis, D. L., Kasperovych, D. V., Kobychev, V. V., Marcucci, G., Melchiorre, A., Menegolli, A., Nisi, S., Musa, M., Pagnanini, L., Pattavina, L., Pessina, G., Pirro, S., Polischuk, O. G., Pozzi, S., Prata, M. C., Puiu, A., Quitadamo, S., Riccardi, M. P., Rossella, M., Rossini, R., Saliu, F., Salvini, A., Scherban, A. P., Solopikhin, D. A., Tretyak, V. I., Trotta, D., and Yuan, H.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The RES-NOVA project is an experimental initiative aimed at detecting neutrinos from the next galactic supernova using PbWO$_{4}$ cryogenic detectors, operated at low temperatures in a low-background environment. By utilizing archaeological lead (Pb) as the target material, RES-NOVA leverages its high radiopurity, large nuclear mass, and the natural abundance of $^{207}$Pb, making it well-suited for exploring both spin-independent and spin-dependent Dark Matter (DM) interactions via nuclear scattering. This work presents a background model developed for the RES-NOVA technology demonstrator and evaluates its implications for Dark Matter detection. Detailed calculations of nuclear matrix elements, combined with the unique properties of archaeological Pb, demonstrate RES-NOVA's potential as a complementary tool to existing direct detection experiments for studying Dark Matter interactions. The experiment will conduct DM searches over a broad mass range spanning 4 orders of magnitude, from sub-GeV/$c^2$ to TeV/$c^2$. In the most optimistic scenario, RES-NOVA is expected to probe DM-nucleon cross-sections down to 1$\times 10^{-43}$ cm$^2$ and 2$\times 10^{-46}$ cm$^2$ for candidates with masses of 2 GeV/$c^2$ and 20 GeV/$c^2$, respectively., Comment: updated limit calculation

Published
2025

2. Search for Fractionally Charged Particles with CUORE

Author

Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Cao, J, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Del Corso, F, Dell’Oro, S, Di Domizio, S, Di Lorenzo, S, Dixon, T, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Girola, M, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Guillaumon, PV, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Keppel, G, Kolomensky, Yu G, Kowalski, R, Liu, R, Ma, L, G., Y, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moore, MN, Napolitano, T, Nastasi, M, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Olmi, M, Oregui, BT, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pottebaum, EG, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, and Schmidt, B

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, CUORE Collaboration, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract

The Cryogenic Underground Observatory for Rare Events (CUORE) is a detector array comprised by 988 5  cm×5  cm×5  cm TeO_{2} crystals held below 20 mK, primarily searching for neutrinoless double-beta decay in ^{130}Te. Unprecedented in size among cryogenic calorimetric experiments, CUORE provides a promising setting for the study of exotic throughgoing particles. Using the first tonne year of CUORE's exposure, we perform a search for hypothesized fractionally charged particles (FCPs), which are well-motivated by various standard model extensions and would have suppressed interactions with matter. Across the searched range of charges e/24-e/2 no excess of FCP candidate tracks is observed over background, setting leading limits on the underground FCP flux with charges e/24-e/5 at 90% confidence level. Using the low background environment and segmented geometry of CUORE, we establish the sensitivity of tonne-scale subkelvin detectors to diverse signatures of new physics.

Published
2024

3. Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society

Author

Devigili, G., Di Stefano, G., Donadio, V., Frattale, I., Grazzi, L., Mantovani, E., Nolano, M., Provitera, V., Quitadamo, S. G., Tamburin, S., Truini, A., Valeriani, M., Furia, A., Vecchio, E., Fischetti, F., Greco, G., Telesca, A., and de Tommaso, M.

Published
2025
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5. Search for fractionally charged particles with CUORE

Author

CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Cao, J., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moore, M. N., Napolitano, T., Nastasi, M., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Oregui, B. T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pottebaum, E. G., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Schmidt, B., Sharma, V., Singh, V., Sisti, M., Speller, D., Stark, P., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, A., Torres, J. A., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The Cryogenic Underground Observatory for Rare Events (CUORE) is a detector array comprised by 988 5$\;$cm$\times$5$\;$cm$\times$5$\;$cm TeO$_2$ crystals held below 20 mK, primarily searching for neutrinoless double-beta decay in $^{130}$Te. Unprecedented in size amongst cryogenic calorimetric experiments, CUORE provides a promising setting for the study of exotic through-going particles. Using the first tonne-year of CUORE's exposure, we perform a search for hypothesized fractionally charged particles (FCPs), which are well-motivated by various Standard Model extensions and would have suppressed interactions with matter. No excess of FCP candidate tracks is observed over background, setting leading limits on the underground FCP flux with charges between $e/24-e/5$ at 90\% confidence level. Using the low background environment and segmented geometry of CUORE, we establish the sensitivity of tonne-scale sub-Kelvin detectors to diverse signatures of new physics., Comment: 7 pages, 5 figures

Published
2024

6. Data-driven background model for the CUORE experiment

Author

CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Cao, J., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moore, M. N., Napolitano, T., Nastasi, M., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Oregui, B. T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Ponce, I., Pottebaum, E. G., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Schmidt, B., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A, Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.

Subjects
Nuclear Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

We present the model we developed to reconstruct the CUORE radioactive background based on the analysis of an experimental exposure of 1038.4 kg yr. The data reconstruction relies on a simultaneous Bayesian fit applied to energy spectra over a broad energy range. The high granularity of the CUORE detector, together with the large exposure and extended stable operations, allow for an in-depth exploration of both spatial and time dependence of backgrounds. We achieve high sensitivity to both bulk and surface activities of the materials of the setup, detecting levels as low as 10 nBq kg$^{-1}$ and 0.1 nBq cm$^{-2}$, respectively. We compare the contamination levels we extract from the background model with prior radio-assay data, which informs future background risk mitigation strategies. The results of this background model play a crucial role in constructing the background budget for the CUPID experiment as it will exploit the same CUORE infrastructure.

Published
2024
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7. The environmental low-frequency background for macro-calorimeters at the millikelvin scale

Author

Aragão, L., Armigliato, A., Brancaccio, R., Brofferio, C., Castellaro, S., D'Addabbo, A., De Luca, G., Del Corso, F., Di Sabatino, S., Liu, R., Marini, L., Nutini, I., Quitadamo, S., Ruggieri, P., Vetter, K. J., Zavatarelli, M., and Zucchelli, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment, Physics - Atmospheric and Oceanic Physics
Abstract

Many of the most sensitive physics experiments searching for rare events, like neutrinoless double beta ($0\nu\beta\beta$) decay and dark matter interactions, rely on cryogenic macro-calorimeters operating at the mK-scale. Located underground at the Gran Sasso National Laboratory (LNGS), in central Italy, CUORE (Cryogenic Underground Observatory for Rare Events) is one of the leading experiments for the search of $0\nu\beta\beta$ decay, implementing the low-temperature calorimetric technology. We present a novel multi-detector analysis to correlate environmental phenomena with the low-frequency noise of low-temperature calorimeters. Indeed, the correlation of marine and seismic data with data from a pair of CUORE detectors indicates that cryogenic detectors are sensitive not only to intense vibrations generated by earthquakes, but also to the much fainter vibrations induced by marine microseisms in the Mediterranean Sea due to the motion of sea waves. Proving that cryogenic macro-calorimeters are sensitive to such environmental sources of noise opens the possibility of studying their impact on the detectors physics-case sensitivity. Moreover, this study could pave the road for technology developments dedicated to the mitigation of the noise induced by marine microseisms, from which the entire community of cryogenic calorimeters can benefit.

Published
2024
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8. With or without $\nu$? Hunting for the seed of the matter-antimatter asymmetry

Author

CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Cao, J., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moore, M. N., Napolitano, T., Nastasi, M., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Oregui, B. T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Ponce, I., Pottebaum, E. G., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Schmidt, B., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A, Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.

Subjects
Nuclear Experiment
Abstract

The matter-antimatter asymmetry underlines the incompleteness of the current understanding of particle physics. Neutrinoless double-beta ($0\nu \beta\beta$) decay may help explain this asymmetry, while unveiling the Majorana nature of the neutrino. The CUORE experiment searches for $0\nu \beta\beta$ decay of $^{130}$Te using a tonne-scale cryogenic calorimeter operated at milli-kelvin temperatures. We report no evidence for $0\nu \beta\beta$ decay and place a lower limit on the half-life of T$_{1/2}$ $>$ 3.8 $\times$ 10$^{25}$ years (90% C.I.) with over 2 tonne$\cdot$year TeO$_2$ exposure. The tools and techniques developed for this result and the 5 year stable operation of nearly 1000 detectors demonstrate the infrastructure for a next-generation experiment capable of searching for $0\nu \beta\beta$ decay across multiple isotopes.

Published
2024

9. Data-driven background model for the CUORE experiment

Author

Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Cao, J, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Del Corso, F, Dell’Oro, S, Di Domizio, S, Di Lorenzo, S, Dixon, T, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Girola, M, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Guillaumon, PV, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Keppel, G, Kolomensky, Yu G, Kowalski, R, Liu, R, Ma, L, G., Y, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moore, MN, Napolitano, T, Nastasi, M, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Olmi, M, Oregui, BT, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Ponce, I, Pottebaum, EG, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, and Schmidt, B

Subjects
Nuclear and Plasma Physics, Physical Sciences, Cancer, NSD-Neutrinos
Abstract

We present the model we developed to reconstruct the CUORE radioactive background based on the analysis of an experimental exposure of 1038.4 kg yr. The data reconstruction relies on a simultaneous Bayesian fit applied to energy spectra over a broad energy range. The high granularity of the CUORE detector, together with the large exposure and extended stable operations, allow for an in-depth exploration of both spatial and time dependence of backgrounds. We achieve high sensitivity to both bulk and surface activities of the materials of the setup, detecting levels as low as 10 nBq kg-1 and 0.1 nBq cm-2, respectively. We compare the contamination levels we extract from the background model with prior radio-assay data, which informs future background risk mitigation strategies. The results of this background model play a crucial role in constructing the background budget for the CUPID experiment as it will exploit the same CUORE infrastructure.

Published
2024

10. Simultaneous Measurement of Half-Life and Spectral Shape of $^{115}$In $\beta$-decay with an Indium Iodide Cryogenic Calorimeter

Author

Pagnanini, L., Benato, G., Carniti, P., Celi, E., Chiesa, D., Corbett, J., Dafinei, I., Di Domizio, S., Di Stefano, P., Ghislandi, S., Gotti, C., Helis, D. L., Knobel, R., Kostensalo, J., Kotila, J., Nagorny, S., Pessina, G., Pirro, S., Pozzi, S., Puiu, A., Quitadamo, S., Sisti, M., Suhonen, J., and Kuznetsov, S.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Current bounds on neutrino Majorana mass are affected by significant uncertainties in the nuclear calculations for neutrinoless double-beta decay. A key issue for a data-driven improvement of the nuclear theory is the actual value of the axial coupling constant $g_A$, which can be investigated through forbidden $\beta$-decays. We present the first measurement of 4$^{th}$-forbidden $\beta$-decay of $^{115}$In with a cryogenic calorimeter based on Indium Iodide. Exploiting the enhanced spectral shape method for the first time to this isotope, our study accurately determines simultaneously spectral shape, $g_A$, and half-life. The Interacting Shell Model, which best fits our data, indicates a half-life for this decay at $T_{1/2}=(5.26\pm0.06) \times 10^{14}$,yr.

Published
2024
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12. Array of Cryogenic Calorimeters to Evaluate the Spectral Shape of forbidden $\beta$-decays: the ACCESS project

Author

Pagnanini, L., Benato, G., Carniti, P., Celi, E., Chiesa, D., Corbett, J., Dafinei, I., Di Domizio, S., Di Stefano, P., Ghislandi, S., Gotti, C., Helis, D. L., Knobel, R., Kostensalo, J., Kotila, J., Nagorny, S., Pessina, G., Pirro, S., Pozzi, S., Puiu, A., Quitadamo, S., Sisti, M., Suhonen, J., and Kuznetsov, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The ACCESS (Array of Cryogenic Calorimeters to Evaluate Spectral Shapes) project aims to establish a novel technique to perform precision measurements of forbidden \b{eta}-decays, which can serve as an important benchmark for nuclear physics calculations and represent a significant background in astroparticle physics experiments. ACCESS will operate a pilot array of cryogenic calorimeters based on natural and doped crystals containing \b{eta}-emitting radionuclides. In this way, natural (e.g. 113 Cd and 115In) and synthetic isotopes (e.g. 99Tc) will be simultaneously measured with a common experimental technique. The array will also include further crystals optimised to disentangle the different background sources, thus reducing the systematic uncertainty. In this paper, we give an overview of the ACCESS research program, discussing a detector design study and promising results of 115In., Comment: 12 pages, 12 figures

Published
2023
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13. A first test of CUPID prototypal light detectors with NTD-Ge sensors in a pulse-tube cryostat

Author

CUPID collaboration, Alfonso, K., Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Berest, V., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Campani, A., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompé, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J. A., Schmidt, B., Sharma, V., Shlegel, V. N., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

CUPID is a next-generation bolometric experiment aiming at searching for neutrinoless double-beta decay with ~250 kg of isotopic mass of $^{100}$Mo. It will operate at $\sim$10 mK in a cryostat currently hosting a similar-scale bolometric array for the CUORE experiment at the Gran Sasso National Laboratory (Italy). CUPID will be based on large-volume scintillating bolometers consisting of $^{100}$Mo-enriched Li$_2$MoO$_4$ crystals, facing thin Ge-wafer-based bolometric light detectors. In the CUPID design, the detector structure is novel and needs to be validated. In particular, the CUORE cryostat presents a high level of mechanical vibrations due to the use of pulse tubes and the effect of vibrations on the detector performance must be investigated. In this paper we report the first test of the CUPID-design bolometric light detectors with NTD-Ge sensors in a dilution refrigerator equipped with a pulse tube in an above-ground lab. Light detectors are characterized in terms of sensitivity, energy resolution, pulse time constants, and noise power spectrum. Despite the challenging noisy environment due to pulse-tube-induced vibrations, we demonstrate that all the four tested light detectors comply with the CUPID goal in terms of intrinsic energy resolution of 100 eV RMS baseline noise. Indeed, we have measured 70--90 eV RMS for the four devices, which show an excellent reproducibility. We have also obtained outstanding energy resolutions at the 356 keV line from a $^{133}$Ba source with one light detector achieving 0.71(5) keV FWHM, which is -- to our knowledge -- the best ever obtained when compared to $\gamma$ detectors of any technology in this energy range., Comment: Prepared for submission to JINST; 16 pages, 7 figures, and 1 table

Published
2023
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14. Twelve-crystal prototype of Li$_2$MoO$_4$ scintillating bolometers for CUPID and CROSS experiments

Author

CUPID, collaborations, CROSS, Alfonso, K., Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Bandac, I. C., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Berest, V., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Calvo-Mozota, J. M., Camilleri, J., Campani, A., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompé, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Ianni, A., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marrache-Kikuchi, C. A., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J. A., Schmidt, B., Sharma, V., Shlegel, V. N., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

An array of twelve 0.28 kg lithium molybdate (LMO) low-temperature bolometers equipped with 16 bolometric Ge light detectors, aiming at optimization of detector structure for CROSS and CUPID double-beta decay experiments, was constructed and tested in a low-background pulse-tube-based cryostat at the Canfranc underground laboratory in Spain. Performance of the scintillating bolometers was studied depending on the size of phonon NTD-Ge sensors glued to both LMO and Ge absorbers, shape of the Ge light detectors (circular vs. square, from two suppliers), in different light collection conditions (with and without reflector, with aluminum coated LMO crystal surface). The scintillating bolometer array was operated over 8 months in the low-background conditions that allowed to probe a very low, $\mu$Bq/kg, level of the LMO crystals radioactive contamination by $^{228}$Th and $^{226}$Ra., Comment: Prepared for submission to JINST; 23 pages, 9 figures, and 4 tables

Published
2023
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15. Development of ultralow-background cryogenic calorimeters for the measurement of surface   α  contamination

Author

Benato, G, Biassoni, M, Brofferio, C, Celi, E, Dell'Oro, S, Drobizhev, A, Gianvecchio, A, Girola, M, Ghislandi, S, Kolomensky, Yu G, Nutini, I, Olmi, M, Pagnanini, L, Puiu, A, and Quitadamo, S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Bolometric α detector, Low-radioactivity measurements, Material screening, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences, Oncology and carcinogenesis
Abstract

Next-generation experiments searching for rare events must satisfy increasingly stringent requirements on the bulk and surface radioactive contamination of their active and structural materials. The measurement of surface contamination is particularly challenging, as no existing technology is capable of separately measuring parts of the 232Th and 238U decay chains that are commonly found to be out of secular equilibrium. We will present the results obtained with a detector prototype consisting of 8 silicon wafers of 150 mm diameter instrumented as bolometers and operated in a low-background dilution refrigerator at the Gran Sasso Underground Laboratory of INFN, Italy. The prototype was characterized by a baseline energy resolution of few keV and a background

Published
2023

16. Status and prospects of discovery of 0??? decay with the CUORE detector

Author

Adams, DQ, Alduino, C, Alfonso, K, Avignone, FTIII, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D'Addabbo, A, Dafinei, I, Del Corso, F, Dell'Oro, S, Di Domizio, S, Di Lorenzo, S, Dompe, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Kowalski, R, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O'Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Ponce, I, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, and Rosenfeld, C

Subjects
Astronomy & Astrophysics, Geophysics, Particle and high energy physics
Abstract

In this contribution we present the achievements of the CUORE experiment so far. It is the first tonne-scale bolometric detector and it is in stable data taking since 2018. We reached to collect about 1800 kg×yr of exposure of which more than 1 ton×year have been analysed. The CUORE detector is meant to search for the neutrinoless double β decay (0νββ) of the 130Te isotope. This is a beyond Standard Model process which could establish the nature of the neutrino to be Dirac or a Majorana particle. It is an alternative mode of the two-neutrinos double β decay, a rare decay which have been precisely measured by CUORE in the 130Te. We found no evidence of the 0νββ and we set a Bayesian lower limit of 2.2 ×1025yr on its half-life. The expertise achieved by CUORE set a milestone for any future bolometric detector, including CUPID, which is the planned next generation experiment searching for 0νββ with scintillating bolometers.

Published
2023

17. Characterization of a kg-scale archaeological lead-based cryogenic detectors for the RES-NOVA experiment

Author

Beeman, J. W., Benato, G., Bucci, C., Canonica, L., Carniti, P., Celi, E., Clemenza, M., D'Addabbo, A., Danevich, F. A., Di Domizio, S., Di Lorenzo, S., Dubovik, O. M., Iachellini, N. Ferreiro, Ferroni, F., Fiorini, E., Fu, S., Garai, A., Ghislandi, S., Gironi, L., Gorla, P., Gotti, C., Guillaumon, P. V., Helis, D. L., Kovtun, G. P., Mancuso, M., Marini, L., Olmi, M., Pagnanini, L., Pattavina, L., Pessina, G., Petricca, F., Pirro, S., Pozzi, S., Puiu, A., Quitadamo, S., Rothe, J., Scherban, A. P., Schönert, S., Solopikhin, D. A., Strauss, R., Tarabini, E., Tretyak, V. I., Tupitsyna, I. A., and Wagner, V.

Subjects
Physics - Instrumentation and Detectors
Abstract

One of the most energetic events in the Universe are core-collapse Supernovae (SNe), where almost all the star's binding energy is released as neutrinos. These particles are direct probes of the processes occurring in the stellar core and provide unique insights into the gravitational collapse. RES-NOVA will revolutionize how we detect neutrinos from astrophysical sources, by deploying the first ton-scale array of cryogenic detectors made from archaeological lead. Pb offers the highest neutrino interaction cross-section via coherent elastic neutrino-nucleus scattering (CE$\nu$NS). Such process will enable RES-NOVA to be equally sensitive to all neutrino flavors. For the first time, we propose to use archaeological Pb as sensitive target material in order to achieve an ultra-low background level in the region of interest (\textit{O}(1keV)). All these features make possible the deployment of the first cm-scale neutrino telescope for the investigation of astrophysical sources. In this contribution, we will characterize the radiopurity level and the performance of a small-scale proof-of-principle detector of RES-NOVA, consisting in a PbWO$_4$ crystal made from archaeological-Pb operated as cryogenic detector.

Published
2022

18. An Energy-dependent Electro-thermal Response Model of CUORE Cryogenic Calorimeter

Author

CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Huang, R. G., Huang, H. Z., Johnston, J., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Li, M., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Sangiorgio, S., Schmidt, B., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Terranova, F., Tomei, C., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wang, B. S., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The Cryogenic Underground Observatory for Rare Events (CUORE) is the most sensitive experiment searching for neutrinoless double-beta decay ($0\nu\beta\beta$) in $^{130}\text{Te}$. CUORE uses a cryogenic array of 988 TeO$_2$ calorimeters operated at $\sim$10 mK with a total mass of 741 kg. To further increase the sensitivity, the detector response must be well understood. Here, we present a non-linear thermal model for the CUORE experiment on a detector-by-detector basis. We have examined both equilibrium and dynamic electro-thermal models of detectors by numerically fitting non-linear differential equations to the detector data of a subset of CUORE channels which are well characterized and representative of all channels. We demonstrate that the hot-electron effect and electric-field dependence of resistance in NTD-Ge thermistors alone are inadequate to describe our detectors' energy dependent pulse shapes. We introduce an empirical second-order correction factor in the exponential temperature dependence of the thermistor, which produces excellent agreement with energy-dependent pulse shape data up to 6 MeV. We also present a noise analysis using the fitted thermal parameters and show that the intrinsic thermal noise is negligible compared to the observed noise for our detectors., Comment: 34 pages, 14 figures, 6 tables

Published
2022

19. New direct limit on neutrinoless double beta decay half-life of $^{128}$Te with CUORE

Author

Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Huang, R. G., Huang, H. Z., Johnston, J., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Ligi, C., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Sangiorgio, S., Schmidt, B., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Terranova, F., Tomei, C., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wang, B. S., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.

Subjects
Nuclear Experiment
Abstract

The Cryogenic Underground Observatory for Rare Events (CUORE) at Laboratori Nazionali del Gran Sasso of INFN in Italy is an experiment searching for neutrinoless double beta (0$\nu\beta\beta$) decay. Its main goal is to investigate this decay in $^{130}$Te, but its ton-scale mass and low background make CUORE sensitive to other rare processes as well. In this work, we present our first results on the search for \nbb decay of $^{128}$Te, the Te isotope with the second highest natural isotopic abundance. We find no evidence for this decay, and using a Bayesian analysis we set a lower limit on the $^{128}$Te \nbb decay half-life of T$_{1/2} > 3.6 \times 10^{24}$ yr (90\% CI). This represents the most stringent limit on the half-life of this isotope, improving by over a factor 30 the previous direct search results, and exceeding those from geochemical experiments for the first time.

Published
2022
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20. Latest Results from the CUORE Experiment

Author

Nutini, I, Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Dell’Oro, S, Domizio, SD, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, YG, Kowalski, R, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, O’Donnell, T, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Rosenfeld, C, Rusconi, C, Sakai, M, Sangiorgio, S, Schmidt, B, Scielzo, ND, and Sharma, V

Subjects
Mathematical Physics, Classical Physics, Condensed Matter Physics, General Physics, Classical physics, Condensed matter physics
Abstract

The Cryogenic Underground Observatory for Rare Events (CUORE) is the first cryogenic experiment searching for 0 νββ decay that has been able to reach the one-tonne mass scale. The detector, located at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, consists of an array of 988 TeO 2 crystals arranged in a compact cylindrical structure of 19 towers. CUORE began its first physics data run in 2017 at a base temperature of about 10 mK and in April 2021 released its 3 rd result of the search for 0 νββ, corresponding to a tonne-year of TeO 2 exposure. This is the largest amount of data ever acquired with a solid state detector and the most sensitive measurement of 0 νββ decay in 130Te ever conducted. We present the current status of CUORE search for 0 νββ with the updated statistics of one tonne-yr. We finally give an update of the CUORE background model and the measurement of the 130Te 2 νββ decay half-life and decay to excited states of 130Xe , studies performed using an exposure of 300.7 kg yr.

Published
2022

21. Expected sensitivity to 128Te neutrinoless double beta decay with the CUORE TeO2 cryogenic bolometers

Author

Dompè, V, Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Dell’Oro, S, Di Domizio, S, Di Lorenzo, S, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Kowalski, R, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, Rusconi, C, Sakai, M, and Sangiorgio, S

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Neutrinoless double beta decay, Tellurium, 128-Te, Cryogenic bolometers, Mathematical Physics, Classical Physics, Condensed Matter Physics, General Physics, Classical physics, Condensed matter physics
Abstract

The CUORE experiment is a ton-scale array of TeO 2 cryogenic bolometers located at the underground Laboratori Nazionali del Gran Sasso of Istituto Nazionale di Fisica Nucleare (INFN), in Italy. The CUORE detector consists of 988 crystals operated as source and detector at a base temperature of ∼ 10 mK. Such cryogenic temperature is reached and maintained by means of a custom built cryogen-free dilution cryostat, designed with the aim of minimizing the vibrational noise and the environmental radioactivity. The primary goal of CUORE is the search for neutrinoless double beta decay of 130Te , but thanks to its large target mass and ultra-low background it is suitable for the study of other rare processes as well, such as the neutrinoless double beta decay of 128Te. This tellurium isotope is an attractive candidate for the search of this process, due to its high natural isotopic abundance of 31.75%. The transition energy at (866.7 ± 0.7) keV lies in a highly populated region of the energy spectrum, dominated by the contribution of the two-neutrino double beta decay of 130Te. As the first ton-scale infrastructure operating cryogenic TeO 2 bolometers in stable conditions, CUORE is able to achieve a factor > 10 higher sensitivity to the neutrinoless double beta decay of this isotope with respect to past direct experiments.

Published
2022

22. New Direct Limit on Neutrinoless Double Beta Decay Half-Life of Te128 with CUORE

Author

Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Del Corso, F, Dell’Oro, S, Di Domizio, S, Di Lorenzo, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Kowalski, R, Liu, R, Ma, L, G., Y, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, Sangiorgio, S, and Schmidt, B

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Half-Life, Bayes Theorem, Granisetron, CUORE Collaboration, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract

The Cryogenic Underground Observatory for Rare Events (CUORE) at Laboratori Nazionali del Gran Sasso of INFN in Italy is an experiment searching for neutrinoless double beta (0νββ) decay. Its main goal is to investigate this decay in ^{130}Te, but its ton-scale mass and low background make CUORE sensitive to other rare processes as well. In this Letter, we present our first results on the search for 0νββ decay of ^{128}Te, the Te isotope with the second highest natural isotopic abundance. We find no evidence for this decay, and using a Bayesian analysis we set a lower limit on the ^{128}Te 0νββ decay half-life of T_{1/2}>3.6×10^{24}  yr (90% CI). This represents the most stringent limit on the half-life of this isotope, improving by over a factor of 30 the previous direct search results, and exceeding those from geochemical experiments for the first time.

Published
2022

23. An energy-dependent electro-thermal response model of CUORE cryogenic calorimeter

Author

Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D'Addabbo, A, Dafinei, I, Del Corso, F, Dell'Oro, S, Di Domizio, S, Di Lorenzo, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Kowalski, R, Li, M, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O'Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, and Sangiorgio, S

Subjects
Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, Cryogenic detectors, Detector modelling and simulations I (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter etc), Double-beta decay detectors, Engineering, Nuclear & Particles Physics, Physical sciences
Abstract

The Cryogenic Underground Observatory for Rare Events (CUORE) is the most sensitive experiment searching for neutrinoless double-beta decay (0νββ) in 130Te. CUORE uses a cryogenic array of 988 TeO2 calorimeters operated at ∼10 mK with a total mass of 741 kg. To further increase the sensitivity, the detector response must be well understood. Here, we present a non-linear thermal model for the CUORE experiment on a detector-by-detector basis. We have examined both equilibrium and dynamic electro-thermal models of detectors by numerically fitting non-linear differential equations to the detector data of a subset of CUORE channels which are well characterized and representative of all channels. We demonstrate that the hot-electron effect and electric-field dependence of resistance in NTD-Ge thermistors alone are inadequate to describe our detectors' energy-dependent pulse shapes. We introduce an empirical second-order correction factor in the exponential temperature dependence of the thermistor, which produces excellent agreement with energy-dependent pulse shape data up to 6 MeV. We also present a noise analysis using the fitted thermal parameters and show that the intrinsic thermal noise is negligible compared to the observed noise for our detectors.

Published
2022

24. Search for Neutrinoless $\beta^+EC$ Decay of $^{120}$Te with CUORE

Author

Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Huang, R. G., Huang, H. Z., Johnston, J., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Ligi, C., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Sakai, M., Sangiorgio, S., Schmidt, B., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Terranova, F., Tomei, C., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wang, B. S., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.

Subjects
Nuclear Experiment
Abstract

CUORE is a large scale cryogenic experiment searching for neutrinoless double beta decay ($0\nu\beta\beta$) in $^{130}$Te. The CUORE detector is made of natural tellurium, providing the possibility of rare event searches on isotopes other than $^{130}$Te. In this work we describe a search for neutrinoless positron emitting electron capture ($0\nu\beta^+EC$) decay in $^{120}$Te with a total TeO$_2$ exposure of 355.7 kg $\cdot$ yr, corresponding to 0.2405 kg $\cdot$ yr of $^{120}$Te. Albeit $0 \nu \beta\beta$ with two final state electrons represents the most promising channel, the emission of a positron and two 511-keV $\gamma$s make $0\nu\beta^+EC$ decay signature extremely clear. To fully exploit the potential offered by the detector modularity we include events with different topology and perform a simultaneous fit of five selected signal signatures. Using blinded data we extract a median exclusion sensitivity of $3.4 \cdot 10^{22}$ yr at 90% Credibility Interval (C.I.). After unblinding we find no evidence of $0\nu\beta^+EC$ signal and set a 90% C.I. Bayesian lower limit of $2.9 \cdot 10^{22}$ yr on $^{120}$Te half-life. This result improves by an order of magnitude the existing limit from the combined analysis of CUORE-0 and Cuoricino.

Published
2022
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25. Toward CUPID-1T

Author

Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Ballen, K., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D., Helis, D. L., Huang, H. Z., Huang, R. G., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mauri, B., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J., Schmidt, B., Sharma, V., Shlegel, V., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.

Subjects
Nuclear Experiment
Abstract

Current experiments to search for broken lepton-number symmetry through the observation of neutrinoless double-beta decay ($0\mathrm{\nu\beta\beta}$) provide the most stringent limits on the Majorana nature of neutrinos and the effective Majorana neutrino mass ($m_{\beta\beta}$). The next-generation experiments will focus on the sensitivity to the $0\mathrm{\nu\beta\beta}$ half-life of $\mathcal{O}(10^{27}$--$10^{28}$~years$)$ and $m_{\beta\beta}\lesssim15$~meV, which would provide complete coverage of the so-called Inverted Ordering region of the neutrino mass parameter space. By taking advantage of recent technological breakthroughs, new, future calorimetric experiments at the 1-ton scale can increase the sensitivity by at least another order of magnitude, exploring the large fraction of the parameter space that corresponds to the Normal neutrino mass ordering. In case of a discovery, such experiments could provide important insights toward a new understanding of the mechanism of $0\mathrm{\nu\beta\beta}$. We present here a series of projects underway that will provide advancements in background reduction, cryogenic readout, and physics searches beyond $0\mathrm{\nu\beta\beta}$, all moving toward the next-to-next generation CUPID-1T detector., Comment: contribution to Snowmass 2021

Published
2022

26. Radiopurity of a kg-scale PbWO$_4$ cryogenic detector produced from archaeological Pb for the RES-NOVA experiment

Author

Beeman, J. W., Benato, G., Bucci, C., Canonica, L., Carniti, P., Celi, E., Clemenza, M., D'Addabbo, A., Danevich, F. A., Di Domizio, S., Di Lorenzo, S., Dubovik, O. M., Iachellini, N. Ferreiro, Ferroni, F., Fiorini, E., Fu, S., Garai, A., Ghislandi, S., Gironi, L., Gorla, P., Gotti, C., Guillaumon, P. V., Helis, D. L., Kovtun, G. P., Mancuso, M., Marini, L., Olmi, M., Pagnanini, L., Pattavina, L., Pessina, G., Petricca, F., Pirro, S., Pozzi, S., Puiu, A., Quitadamo, S., Rothe, J., Scherban, A. P., Schoenert, S., Solopikhin, D. A., Strauss, R., Tarabini, E., Tretyak, V. I., Tupitsyna, I. A., and Wagner, V.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

RES-NOVA is a newly proposed experiment for the detection of neutrinos from astrophysical sources, mainly Supernovae, using an array of cryogenic detectors made of PbWO$_4$ crystals produced from archaeological Pb. This unconventional material, characterized by intrinsic high radiopurity, enables to achieve low-background levels in the region of interest for the neutrino detection via Coherent Elastic neutrino-Nucleus Scattering (CE$\nu$NS). This signal lies at the detector energy threshold, O(1 keV), and it is expected to be hidden by naturally occurring radioactive contaminants of the crystal absorber. Here, we present the results of a radiopurity assay on a 0.84 kg PbWO$_4$ crystal produced from archaeological Pb operated as a cryogenic detector. The crystal internal radioactive contaminations are: $^{232}$Th $<$40 $\mu$Bq/kg, $^{238}$U $<$30 $\mu$Bq/kg, $^{226}$Ra 1.3 mBq/kg and $^{210}$Pb 22.5 mBq/kg. We present also a background projection for the final experiment and possible mitigation strategies for further background suppression. The achieved results demonstrate the feasibility of realizing this new class of detectors., Comment: New analysis with high statistic

Published
2022
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27. Optimization of the first CUPID detector module

Author

CUPID collaboration, Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Ballen, K., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Huang, R. G., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M ., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mauri, B., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J., Schmidt, B., Sharma, V., Shlegel, V., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

CUPID will be a next generation experiment searching for the neutrinoless double $\beta$ decay, whose discovery would establish the Majorana nature of the neutrino. Based on the experience achieved with the CUORE experiment, presently taking data at LNGS, CUPID aims to reach a background free environment by means of scintillating Li$_{2}$$^{100}$MoO$_4$ crystals coupled to light detectors. Indeed, the simultaneous heat and light detection allows us to reject the dominant background of $\alpha$ particles, as proven by the CUPID-0 and CUPID-Mo demonstrators. In this work we present the results of the first test of the CUPID baseline module. In particular, we propose a new optimized detector structure and light sensors design to enhance the engineering and the light collection, respectively. We characterized the heat detectors, achieving an energy resolution of (5.9 $\pm$ 0.2) keV FWHM at the $Q$-value of $^{100}$Mo (about 3034 keV). We studied the light collection of the baseline CUPID design with respect to an alternative configuration which features gravity-assisted light detectors' mounting. In both cases we obtained an improvement in the light collection with respect to past measures and we validated the particle identification capability of the detector, which ensures an $\alpha$ particle rejection higher than 99.9%, fully satisfying the requirements for CUPID., Comment: 10 pages, 5 figures

Published
2022

28. Search for neutrinoless β+EC decay of Te120 with CUORE

Author

Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, C, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D'Addabbo, A, Dafinei, I, Del Corso, F, Dell'Oro, S, Di Domizio, S, Di Lorenzo, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Kowalski, R, Ligi, C, Liu, R, Ma, L, G., Y, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O'Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, and Sakai, M

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Synchrotrons and Accelerators, Physical Sciences, Cardiovascular, Nuclear and plasma physics
Abstract

The Cryogenic Underground Observatory for Rare Events (CUORE) is a large-scale cryogenic experiment searching for neutrinoless double-beta decay (0νββ) in Te130. The CUORE detector is made of natural tellurium, providing the possibility of rare event searches on isotopes other than Te130. In this work we describe a search for neutrinoless positron-emitting electron capture (β+EC) decay in Te120 with a total TeO2 exposure of 355.7 kg yr, corresponding to 0.2405 kg yr of Te120. Albeit 0νββ with two final-state electrons represents the most promising channel, the emission of a positron and two 511-keV γ's make 0νβ+EC decay signature extremely clear. To fully exploit the potential offered by the detector modularity we include events with different topology and perform a simultaneous fit of five selected signal signatures. Using blinded data we extract a median exclusion sensitivity of 3.4×1022 yr at 90% credibility interval (C.I.). After unblinding we find no evidence of 0νβ+EC signal and set a 90% C.I. Bayesian lower limit of 2.9×1022 yr on Te120 half-life. This result improves by an order of magnitude the existing limit from the combined analysis of CUORE-0 and Cuoricino.

Published
2022

29. An acrylic assembly for low temperature detectors

Author

Biassoni, M., Brofferio, C., Faverzani, M., Ferri, E., Ghislandi, S., Milana, S., Nutini, I., Pettinacci, V., Pozzi, S., and Quitadamo, S.

Subjects
Physics - Instrumentation and Detectors, Physics - Applied Physics
Abstract

Thermal detectors are a powerful instrument for the search of rare particle physics events. Inorganic crystals are classically used as thermal detectors held in supporting frames made of copper. In this work a novel approach to the operation of thermal detectors is presented, where TeO2 crystals are cooled down to ~ 10 mK in a light structure built with plastic materials. The advantages of this approach are discussed., Comment: 8 pages, 9 figures

Published
2021

30. CUORE Opens the Door to Tonne-scale Cryogenics Experiments

Author

CUORE Collaboration, Adams, D. Q., Alduino, C., Alessandria, F., Alfonso, K., Andreotti, E., Avignone III, F. T., Azzolini, O., Balata, M., Bandac, I., Banks, T. I., Bari, G., Barucci, M., Beeman, J. W., Bellini, F., Benato, G., Beretta, M., Bersani, A., Biare, D., Biassoni, M., Bragazzi, F., Branca, A., Brofferio, C., Bryant, A., Buccheri, A., Bucci, C., Bulfon, C., Camacho, A., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, S., Capodiferro, M., Cappelli, L., Cardani, L., Cariello, M., Carniti, P., Carrettoni, M., Casali, N., Cassina, L., Celi, E., Cereseto, R., Ceruti, G., Chiarini, A., Chiesa, D., Chott, N., Clemenza, M., Conventi, D., Copello, S., Cosmelli, C., Cremonesi, O., Crescentini, C., Creswick, R. J., Cushman, J. S., D'Addabbo, A., D'Aguanno, D., Dafinei, I., Datskov, V., Davis, C. J., Del Corso, F., Dell'Oro, S., Deninno, M. M., Di Domizio, S., Dompè, V., Di Vacri, M. L., Di Paolo, L., Drobizhev, A., Ejzak, L., Faccini, R., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Gaigher, R., Ghislandi, S., Giachero, A., Gironi, L., Giuliani, A., Gladstone, L., Goett, J., Gorla, P., Gotti, C., Guandalini, C., Guerzoni, M., Guetti, M., Gutierrez, T. D., Haller, E. E., Han, K., Hansen, E. V., Heeger, K. M., Hennings-Yeomans, R., Hickerson, K. P., Huang, R. G., Huang, H. Z., Iannone, M., Ioannucci, L., Johnston, J., Kadel, R., Keppel, G., Kogler, L., Kolomensky, Yu. G., Leder, A., Ligi, C., Lim, K. E., Liu, R., Ma, L., Ma, Y. G., Maiano, C., Maino, M., Marini, L., Martinez, M., Amaya, C. Martinez, Maruyama, R. H., Mayer, D., Mazza, R., Mei, Y., Moggi, N., Morganti, S., Mosteiro, P. J., Nagorny, S. S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novati, V., Nucciotti, A., Nutini, I., O'Donnell, T., Olcese, M., Olivieri, E., Orio, F., Orlandi, D., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Palmieri, V., Pattavina, L., Pavan, M., Pedretti, M., Pedrotta, R., Pelosi, A., Perego, M., Pessina, G., Pettinacci, V., Piperno, G., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Reindl, F., Rimondi, F., Risegari, L., Rosenfeld, C., Rossi, C., Rusconi, C., Sakai, M., Sala, E., Salvioni, C., Sangiorgio, S., Santone, D., Schaeffer, D., Schmidt, B., Schmidt, J., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Smith, A. R., Speller, D., Stivanello, F., Surukuchi, P. T., Taffarello, L., Tatananni, L., Tenconi, M., Terranova, F., Tessaro, M., Tomei, C., Ventura, G., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wallig, J., Wang, B. S., Wang, H. W., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Wise, T., Zanotti, L., Zarra, C., Zhang, G. Q., Zhu, B. X., Zimmermann, S., and Zucchelli, S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The past few decades have seen major developments in the design and operation of cryogenic particle detectors. This technology offers an extremely good energy resolution - comparable to semiconductor detectors - and a wide choice of target materials, making low temperature calorimetric detectors ideal for a variety of particle physics applications. Rare event searches have continued to require ever greater exposures, which has driven them to ever larger cryogenic detectors, with the CUORE experiment being the first to reach a tonne-scale, mK-cooled, experimental mass. CUORE, designed to search for neutrinoless double beta decay, has been operational since 2017 at a temperature of about 10 mK. This result has been attained by the use of an unprecedentedly large cryogenic infrastructure called the CUORE cryostat: conceived, designed and commissioned for this purpose. In this article the main characteristics and features of the cryogenic facility developed for the CUORE experiment are highlighted. A brief introduction of the evolution of the field and of the past cryogenic facilities are given. The motivation behind the design and development of the CUORE cryogenic facility is detailed as are the steps taken toward realization, commissioning, and operation of the CUORE cryostat. The major challenges overcome by the collaboration and the solutions implemented throughout the building of the cryogenic facility will be discussed along with the potential improvements for future facilities. The success of CUORE has opened the door to a new generation of large-scale cryogenic facilities in numerous fields of science. Broader implications of the incredible feat achieved by the CUORE collaboration on the future cryogenic facilities in various fields ranging from neutrino and dark matter experiments to quantum computing will be examined., Comment: 45 pages, 14 figures

Published
2021
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31. Latest results from the CUORE experiment

Author

Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D'Addabbo, A, Dafinei, I, Dell'Oro, S, Di Domizio, S, Di Lorenzo, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, YG, Kowalski, R, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O'Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, Rusconi, C, Sakai, M, and Sangiorgio, S

Abstract

The CUORE experiment is searching for the neutrinoless double β decay of the 130Te using cryogenic calorimeters. The CUORE detector consists of 988 TeO2 crystals packed in 19 towers and placed in a cryogenic facility with a base temperature of 10 mK. Crystals are enriched in the isotope 130Te which is the candidate for the neutrinoless double β decay. It is taking data since 2017 at the Laboratori Nazionali del Gran Sasso in Italy. Such a long operation of a bolometric experiment in stable condition has no precedent: by reaching 1 tonne-year of exposure CUORE set a fundamental milestone for any future experiment using this technology. The CUORE collaboration investigated the neutrinoless double β decay of 130Te exploiting the updated 1 tonne-year of statistics, setting a limit of 2.2 × 1025 yr at the 90% of credibility interval on the half-life, with a median sensitivity of 2.8 × 1025 yr.

Published
2022

34. CUPID: The Next-Generation Neutrinoless Double Beta Decay Experiment

Author

Alfonso, K., Armatol, A., Augier, C., Avignone, III, F. T., Azzolini, O., Balata, M., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Campani, A., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D’Addabbo, A., D’Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., De Marcillac, P., Dell’Oro, S., Domizio, S. Di, Lorenzo, S. Di, Dixon, T., Dompè, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mauri, B., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O’Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J. A., Schmidt, B., Sharma, V., Shlegel, V. N., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.

Published
2022
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37. Recent trends in foreign body ingestion (FBI) epidemiology: A national cohort study.

Author

Mantegazza, Cecilia, Destro, Francesca, Ferraro, Simona, Biganzoli, Davide, Marano, Giuseppe, Quitadamo, Paolo, Nardo, Giovanni Di, Malamisura, Monica, Chiarazzo, Giulia, Renzo, Sara, Scarallo, Luca, Fava, Giorgio, Ichino, Martina, Panceri, Roberto, Sala, Debora, Pellegrino, Maristella, Macchini, Francesco, Gandullia, Paolo, Tantari, Giacomo, and Bramuzzo, Matteo

Abstract

Foreign body ingestion (FBI) in children is a critical health concern. This study aimed to describe the epidemiology of FBI in children in Italy. We retrospectively enrolled children <18 years admitted for FBI from January 2015 to December 2020. Data were collected across 21 hospitals with dedicated pediatric endoscopy services and normalized by the population of the corresponding municipalities. A total of 5,771 FBI cases were analyzed. FBI incidents showed consistent time trends across age groups, with most events occurring at home and being witnessed (94.7 %). Children <6 years accounted for 74.3 % of cases. Comorbidities were present in 5.3 % of cases, primarily neurologic/psychiatric disorders in older children (6–17 years). Blunt objects accounted for 65.5 % of ingestions. Young males commonly ingested button batteries, while females showed higher rates of ingesting hair products and jewelry. Most children were discharged (60 %) or observed briefly (75 % of total admissions), with endoscopic removal performed in 24 % of cases. Rates of FBI have remained stable over the years, including during the COVID-19 pandemic. FBI predominantly occurs in domestic settings among healthy young children, particularly those ≤5 years old. These findings emphasize the need for preventive measures to reduce the impact of FBI among children. [ABSTRACT FROM AUTHOR]

Published
2025
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39. Cyclic vomiting syndrome in children: a nationwide survey of current practice on behalf of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP)

Author

Isoldi, Sara, Di Nardo, Giovanni, Mallardo, Saverio, Parisi, Pasquale, Raucci, Umberto, Tambucci, Renato, Quitadamo, Paolo, Salvatore, Silvia, Felici, Enrico, Cisarò, Fabio, Pensabene, Licia, Banzato, Claudia, Strisciuglio, Caterina, Romano, Claudio, Fusco, Patrizia, Rigotti, Francesca, Sansotta, Naire, Caimmi, Silvia, Savasta, Salvatore, Zuin, Giovanna, Di Stefano, Marina, Provera, Silvia, Campanozzi, Angelo, Rossi, Paolo, Gatti, Simona, Corpino, Mara, Alvisi, Patrizia, Martelossi, Stefano, Suppiej, Agnese, Gandullia, Paolo, Verrotti, Alberto, Terrin, Gianluca, Pacenza, Caterina, Fornaroli, Fabiola, Comito, Donatella, D’Arrigo, Stefano, Striano, Pasquale, Raviglione, Federico, Carotenuto, Marco, Orsini, Alessandro, Belcastro, Vincenzo, Di Corcia, Giovanna, Raieli, Vincenzo, Ferilli, Michela Ada Noris, Ruscitto, Claudia, Spadoni, Elisabetta, Grosso, Salvatore, D’Alonzo, Renato, Papa, Amanda, Pavone, Piero, Meli, Mariaclaudia, Velardita, Mario, Mainetti, Martina, Vanacore, Nicola, and Borrelli, Osvaldo

Published
2022
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41. Optimization of the first CUPID detector module

Author

Alfonso, K., Armatol, A., Augier, C., Avignone, III, F. T., Azzolini, O., Balata, M., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Campani, A., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D’Addabbo, A., D’Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dell’Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mauri, B., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O’Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J., Schmidt, B., Sharma, V., Shlegel, V. N., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.

Published
2022
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46. An integrated map of structural variation in 2,504 human genomes.

Author

Sudmant, Peter H, Rausch, Tobias, Gardner, Eugene J, Handsaker, Robert E, Abyzov, Alexej, Huddleston, John, Zhang, Yan, Ye, Kai, Jun, Goo, Fritz, Markus Hsi-Yang, Konkel, Miriam K, Malhotra, Ankit, Stütz, Adrian M, Shi, Xinghua, Casale, Francesco Paolo, Chen, Jieming, Hormozdiari, Fereydoun, Dayama, Gargi, Chen, Ken, Malig, Maika, Chaisson, Mark JP, Walter, Klaudia, Meiers, Sascha, Kashin, Seva, Garrison, Erik, Auton, Adam, Lam, Hugo YK, Mu, Xinmeng Jasmine, Alkan, Can, Antaki, Danny, Bae, Taejeong, Cerveira, Eliza, Chines, Peter, Chong, Zechen, Clarke, Laura, Dal, Elif, Ding, Li, Emery, Sarah, Fan, Xian, Gujral, Madhusudan, Kahveci, Fatma, Kidd, Jeffrey M, Kong, Yu, Lameijer, Eric-Wubbo, McCarthy, Shane, Flicek, Paul, Gibbs, Richard A, Marth, Gabor, Mason, Christopher E, Menelaou, Androniki, Muzny, Donna M, Nelson, Bradley J, Noor, Amina, Parrish, Nicholas F, Pendleton, Matthew, Quitadamo, Andrew, Raeder, Benjamin, Schadt, Eric E, Romanovitch, Mallory, Schlattl, Andreas, Sebra, Robert, Shabalin, Andrey A, Untergasser, Andreas, Walker, Jerilyn A, Wang, Min, Yu, Fuli, Zhang, Chengsheng, Zhang, Jing, Zheng-Bradley, Xiangqun, Zhou, Wanding, Zichner, Thomas, Sebat, Jonathan, Batzer, Mark A, McCarroll, Steven A, 1000 Genomes Project Consortium, Mills, Ryan E, Gerstein, Mark B, Bashir, Ali, Stegle, Oliver, Devine, Scott E, Lee, Charles, Eichler, Evan E, and Korbel, Jan O

Subjects
Genomes Project Consortium, Humans, Genetic Predisposition to Disease, Physical Chromosome Mapping, Sequence Analysis, DNA, Genetics, Medical, Genetics, Population, Genomics, Sequence Deletion, Amino Acid Sequence, Genotype, Haplotypes, Homozygote, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Genome, Human, Molecular Sequence Data, Genetic Variation, Genome-Wide Association Study, Mutation Rate, Sequence Analysis, DNA, Genetics, Medical, Population, Polymorphism, Single Nucleotide, Genome, Human, General Science & Technology
Abstract

Structural variants are implicated in numerous diseases and make up the majority of varying nucleotides among human genomes. Here we describe an integrated set of eight structural variant classes comprising both balanced and unbalanced variants, which we constructed using short-read DNA sequencing data and statistically phased onto haplotype blocks in 26 human populations. Analysing this set, we identify numerous gene-intersecting structural variants exhibiting population stratification and describe naturally occurring homozygous gene knockouts that suggest the dispensability of a variety of human genes. We demonstrate that structural variants are enriched on haplotypes identified by genome-wide association studies and exhibit enrichment for expression quantitative trait loci. Additionally, we uncover appreciable levels of structural variant complexity at different scales, including genic loci subject to clusters of repeated rearrangement and complex structural variants with multiple breakpoints likely to have formed through individual mutational events. Our catalogue will enhance future studies into structural variant demography, functional impact and disease association.

Published
2015

47. Peer-Led Team Learning: A Prospective Method for Increasing Critical Thinking in Undergraduate Science Courses

Author

Quitadamo, Ian J., Brahler, C. Jayne, and Crouch, Gregory J.

Abstract

Peer-Led Team Learning (PLTL) is a specific form of small group learning recognized by Project Kaleidoscope as best practice pedagogy (Varma-Nelson, 2004). PLTL was first developed by Woodward, Gosser, and Weiner (1993) as an integrated method that promoted discourse and creative problem solving in chemistry at the City College of New York. It is characterized by a cohort-based social learning structure whereby trained undergraduates, or "peer leaders", guide 4-8 less experienced peers toward conceptual understanding through group-focused science and math problem solving. This study examines the impact of PLTL on critical thinking gains in science and math courses at a research university in the Pacific Northwest. Results of this study show that PLTL has a small but positive impact on critical thinking gains in some science courses, and that it improves grade performance and retention in science and math courses, particularly for females. While math students did not show significant critical thinking gains, it is premature to conclude that PLTL does not promote critical thinking in math. Many factors affect the development of critical thinking skills, and more study is necessary to discover their influence. These results indicate PLTL has potential to improve undergraduate critical thinking. (Contains 2 figures and 3 tables.)

Published
2009

48. Effective Teaching Styles and Instructional Design for Online Learning Environments.

Author

Quitadamo, Ian J. and Brown, Abbie

Abstract

Internet-based, distance learning solutions are finding increased use and may prove effective in facilitating advanced study coursework for remotely located, place-bound students. Despite the current emphasis on distance learning, the conditions for promoting online learning success have not been entirely defined. This paper presents a case study that profiles the teaching challenges and benefits of an online graduate-level Instructional Design course for in-service teachers taught through Western Governors University and Washington State University. The paper addresses some of the teaching challenges for this online instructional experience, focusing specifically on how teaching styles were used to build online learning community, effectively promote productive and satisfying learning interactions, and develop student problem-solving and critical thinking abilities. Also discussed are those instructional design strategies that were repeatedly employed in multiple course sections to increase online student engagement, encourage critical thinking, and enhance student learning. The findings of this study should prove of interest to anyone currently developing or delivering online instruction. (Contains 34 references.) (Author/MES)

Published
2001

50. Children’s rare disease cohorts: an integrative research and clinical genomics initiative

Author

Rockowitz, Shira, LeCompte, Nicholas, Carmack, Mary, Quitadamo, Andrew, Wang, Lily, Park, Meredith, Knight, Devon, Sexton, Emma, Smith, Lacey, Sheidley, Beth, Field, Michael, Holm, Ingrid A., Brownstein, Catherine A., Agrawal, Pankaj B., Kornetsky, Susan, Poduri, Annapurna, Snapper, Scott B., Beggs, Alan H., Yu, Timothy W., Williams, David A., and Sliz, Piotr

Published
2020
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