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Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cause of end-stage kidney disease. Currently, tolvaptan is the only treatment that has proven to delay disease progression. The most notable side effect of this therapy is drug-induced liver injury; however, recently, there have been two reports of creatine kinase (CK) elevation in ADPKD patients on tolvaptan treatment. We set out to monitor and determine the actual incidence of CK elevation and evaluate its potential association with other clinical factors. Methods: This is an observational retrospective multicenter study performed in rapidly progressive ADPKD patients on tolvaptan treatment from Barcelona, Spain. Laboratory tests, demographics, treatment dose, and reported symptoms were collected from October 2018 to March 2021. Results: Ninety-five patients initiated tolvaptan treatment during follow-up. The medication had to be discontinued in 31 (32.6%) patients, primarily due to aquaretic effects (12.6%), elevated liver enzymes (8.4%), and symptomatic or persistently elevated CK levels (3.2%). Moreover, a total of 27 (28.4%) patients had elevated CK levels, with most of them being either transient (12.6%), mild and asymptomatic (4.2%), or resolved after dose reduction (3.2%) or temporary discontinuation (2.1%). Conclusion: We pre­sent the largest cohort that has monitored CK levels in a real-life setting, finding them elevated in 28.4% of patients. More research and monitoring will help us understand the clinical implications and the pathophysiological mechanism of CK elevation in this population.

Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz O quisto é uma lesão periapical que se caracteriza por ser uma cavidade patológica revestida de epitélio que contém uma parte líquida e outra semissólida, tais como muco, queratina e resíduos celulares. Estes quistos podem ser odontogénicos e não-odontogénicos. Para o diagnóstico destes quistos é necessário recorrer a exames de imagem e meios complementares dada a sua facilidade de acesso e relevância na informação para o diagnóstico. O CBCT, sendo um exame tridimensional, fornece-nos informação mais precisas. No entanto, segundo investigações mais recentes, a ressonância magnética é o meio mais vantajoso para um correto diagnóstico. As radiografias e a tomografia computarizada fornecem-nos informação sobre a anatomia destas lesões, mas a ressonância magnética ajuda-nos a compreender a natureza do quisto. Os quistos nas radiografias apresentam-se como imagens translúcidas rodeadas por bordos definidos. As características radiográficas destas lesões permitem-nos um diagnóstico diferencial. É fundamental realizar uma minuciosa história clínica e determinar a localização da lesão e os efeitos sobre as estruturas adjacentes. A interpretação das radiografias orais é uma técnica muito importante para o diagnóstico de lesões, nomeadamente cáries, doença periodontal, ou até mesmo mudanças neoplásicas e reabsorções ósseas causadas por quistos. Um diagnóstico precoce previne um avanço do grau de reabsorção do osso da mandíbula. Este trabalho pretende efetuar uma pesquisa bibliográfica com análise de artigos e documentos de interesse científico relevantes, de modo a conseguir identificar cada quisto da cavidade oral, utilizando os diferentes meios complementares. The cyst is a periapical lesion that is characterized as a pathological cavity lined with epithelium that contains a liquid and a semisolid part, such as mucus, keratin and cellular debris. These cysts can be odontogenic and non-odontogenic. For the diagnosis of these cysts, it is necessary to use imaging exams and complementary means given their ease of access and relevance in information for diagnosis. CBCT, being a three-dimensional exam, provides us with more accurate information. However, according to more recent research, MRI is the most advantageous means for accurate diagnosis. Radiographs and computed tomography provide us with information about the anatomy of these lesions, but MRI helps us understand the nature of the cyst. Cysts on radiographs present as translucent images surrounded by defined borders. The radiographic features of these lesions allow us to make a differential diagnosis. It is essential to take a thorough clinical history and determine the location of the lesion and the effects on adjacent structures. The interpretation of oral radiographs is a very important technique for the diagnosis of lesions, namely caries, periodontal disease, or even neoplastic changes and bone resorption caused by cysts. An early diagnosis prevents the degree of resorption of the jaw bone from advancing. This work aims to carry out a literature search with analysis of relevant articles and documents of scientific interest, in order to be able to identify each cyst of the oral cavity, using the different complementary means.

An 18-year-old boy presented to our emergency department with a 1-month history of a painful left eye, photophobia, and progressive blurring of vision. His past ocular history included a penetrating left globe injury, surgically repaired 1 year before. Biomicroscopy revealed a scar in the inferior cornea and a huge epithelial iris cyst, reaching the visual axis (Panel A). BCVA of the left eye was 20/320, and intraocular pressure was 20 mmHg. Further investigation, namely ultrasound biomicroscopy (Panel B), and anterior segment-OCT (not shown) supported this diagnosis. Nd: YAG laser cystotomy was performed to rupture the cyst wall and drain its fluid content. Immediate shrinkage of the cyst was seen, but additional follow-up is required to rule out the development of procedure-related complications and cyst recurrence. With the evolution of surgical techniques, posttraumatic iris cysts have become rare entities. Nevertheless, its recognition and management are mandatory for any ophthalmologist.

Background Odontogenic keratocysts (OKC) are cystic lesions appearing in the jaws, usually asymptomatic with a progressive growth into the bone. Many of them are diagnosed by a routine radiological examination. Material and methods This study reports a 12-year-old girl that presented an asymptomatic large radiolucent unilocular lesion associated to the crown of 3.8 that caused displacement of the molar and the inferior alveolar canal. Differential diagnosis included OKC, unicystic ameloblastoma, ameloblastic fibroma, dentigerous cyst and orthokeratinized odontogenic cyst. Two surgical interventions were performed; first, a marsupialization, and 10 months after, the third molar extraction plus cyst enucleation, mucosa excision and the application of Carnoy's solution. Results The anatomopathological exam confirmed diagnosis of OKC. There was no evidence of recurrence after 2 years of follow-up. Conclusions Marsupialization followed by surgical enucleation with mucosa excision and Carnoy's solution can help manage treatment of OKC, a lesion characterized by an aggressive behavior. Key words:Odontogenic keratocyst, mucosa excision, carnoy solution, third molar, tooth extraction.

Vitreous cysts are a rare and mostly accidental finding. We report a case of a 4-year-old male without a relevant medical history who resorted to a routine ophthalmology consultation. On ophthalmological examination, he had a 6/10 (Snellen decimal scale) best corrected visual acuity in both eyes. Biomicroscopy showed a pigmented and rounded lesion (3 mm of larger diameter), located in the anterior vitreous of the left eye, that moved with eye movements. Besides this lesion and the shadow-effect it produced in the retina, there were no other changes in fundus examination. Associated inflammatory/infectious pathologies were excluded. At 6-month and 1-year follow-up, no new symptoms or morphological changes of the lesion were found. The etiology of vitreous cysts is diverse, requiring a thorough study and close follow-up in order to decide the most appropriate approach., Os quistos vítreos são um achado raro e maioritariamente acidental. Apresentamos o caso de uma criança do sexo masculino, 4 anos, sem antecedentes de relevo, que recorreu à consulta de oftalmologia para rastreio ocular. Ao exame oftalmológico apresentava uma melhor acuidade visual corrigida de 6/10 (escala decimal) em ambos os olhos e, à biomicroscopia, visualizava-se uma lesão pigmentada e arredondada no vítreo anterior do olho esquerda, com cerca de 3 milímetros de maior diâmetro, que se deslocava com os movimentos oculares. Além da lesão e da sombra que produzia na retina, não se observaram alterações na fundoscopia. Excluíram-se patologias sistémicas inflamatórias/infeciosas associadas. Aos 6 meses de seguimento não se constatou agravamento dos sintomas ou alterações morfológicas da lesão. A etiologia dos quistos vítreos é diversa, exigindo um estudo completo e seguimento apertado de forma a decidir a abordagem mais adequada.

Metformin is currently used to improve pregnancy outcome in women affected by polycystic ovary syndrome (PCOS) or diabetes. However, metformin may also be useful in pregnancies at risk of intrauterine growth restriction (IUGR) since it improves placental efficiency and the fetuses&rsquo, developmental competence. There is no data on the duration of the effect of this treatment from the prenatal up to the postnatal stages. Therefore, the present trial aimed at determining the impact of metformin treatment on the offspring neonatal traits and early postnatal development (i.e., during lactation) using an in vivo swine model. The results support that maternal metformin treatment during pregnancy induces protective changes in body shape and composition of the progeny (i.e., larger head size and body length at birth and higher total viscera weight at weaning). However, there were also major effects of the offspring sex (smaller corpulence in females and lower relative weight of main viscerae in males), which should be considered for further preclinical studies and when even the current clinical application in women affected by PCOS or diabetes is implemented.

Background. A solitary bone cyst or simple bone cyst is a nonneoplastic osseous lesion, with no epithelial lining, also considered as a pseudocyst. These lesions, with an intact bony wall and fluid-filled, are frequently discovered by chance in radiological studies. The etiopathogenesis has not been studied in depth, and the management remains controversial. Case Presentation. We present a clinical case of a 15-year-old boy who underwent an orthopantomography to assess the development and position of the third molars during a routine postorthodontic check-up. By chance, the X-ray identified an asymptomatic radiolucent image in the left jaw, measuring 12.0 mm×17.8 mm and compatible with a solitary bone cyst involving teeth 35 and 36. We describe our technique for performing minimally invasive decompression of the lesion using a microperforated catheter. We describe the entire course of the follow-up, both clinical and radiological, until complete cure. Conclusions. This straightforward continuous decompression technique poses no problems for the patient, has a low risk of sequelae, and is clearly cost-effective. In view of the highly satisfactory evolution, whenever possible, we favor this minimally invasive technique for the treatment of solitary bone cysts in the jaw.

Potato cyst nematodes (PCN), Globodera rostochiensis and G. pallida, are a serious threat to potato crops worldwide. Due to the risk these two species pose, a national survey was implemented starting in 2010 aiming to know the presence and distribution of these quarantine nematodes in Portugal. This fact has led to an increasing demand to accurately identify the PCN species present in the fields. Usually, the identification is based on morphology followed by molecular analysis. Considering there is at least one laboratory in the EU certified for morphological identification of PCN, the aim of this study was to look into the possibility of using only morphological diagnostic characters for routine purposes. Forty cysts of Globodera were used, for morphological and molecular analyses. Morphological analysis allowed the identification of 23 cysts as G. rostochiensis and 17 cysts as G. pallida and the molecular results revealed that 9 cysts were G. rostochiensis and 31 cysts were G. pallida. Thus, morphological and molecular analyses matched 65%, concluding that in our routine analyses only an initial morphological approach followed by molecular methods enables a reliable identification of PCN species. So, it is recommended to combine both methods. PCR can be ruled out only if the purpose is to detect Globodera nematodes, which is the case of the seed potato fields where the presence of round-cyst nematodes will interdict the seed production., Os nemátodes de quisto da batateira (NQB), Globodera rostochiensis e G. pallida, são uma ameaça para a cultura da batata a nível mundial. Devido ao risco que estas duas espécies representam, foi implementado um programa de prospeção nacional a partir de 2010 com o objectivo de detetar a presença e conhecer a distribuição destes nemátodes de quarentena em Portugal. Este facto intensificou a necessidade de determinar com precisão as espécies de NQB presentes nos campos de batata. Geralmente, esta identificação é baseada na avaliação das características morfológicas, confirmada de seguida pela análise molecular. Considerando que existe pelo menos um laboratório na União Europeia certificado para a identificação morfológica de NQB, o objetivo deste estudo foi investigar a possibilidade de identificar estas espécies apenas através das características morfológicas, em análises de rotina. Para as análises morfológicas e moleculares foram utilizados 40 quistos de Globodera sp.. A análise morfológica permitiu identificar 23 quistos como G. rostochiensis e 17 quistos como G. pallida, enquanto que os resultados moleculares para os mesmos quistos permitiram a identificação de 9 quistos como G. rostochiensis e 31 quistos como G. pallida. As análises morfológicas e moleculares apenas coincidiram em 65% dos casos. Concluiu-se que nas nossas análises de rotina apenas a utilização das duas abordagens permite a identificação precisa de espécies de NQB, sendo por isso recomendado combinar sempre os dois métodos. A análise molecular pode ser excluída somente se o objetivo visar a deteção de nemátodes do género Globodera, como é o caso dos campos de batata de semente, onde a presença de qualquer espécie destes nemátodes interditará a produção de semente.

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy characterized by dysfunction of the role of glial cells in controlling brain fluid and ion homeostasis. Patients affected by MLC present macrocephaly, cysts and white matter vacuolation, which lead to motor and cognitive impairments. To date, there is no treatment for MLC, only supportive care. MLC is caused by mutations in the MLC1 and GLIALCAM genes. MLC1 is a membrane protein with low identity to the Kv1.1 potassium channel and GlialCAM belongs to an adhesion molecule family. Both proteins form a complex with an as-yet-unknown function that is expressed mainly in the astrocytes surrounding the blood-brain barrier and in Bergmann glia. GlialCAM also acts as an auxiliary subunit of the chloride channel ClC-2, thus regulating its localization at cell-cell junctions and modifying its functional properties by affecting the common gate of ClC-2. Recent studies in Mlc1-, GlialCAM- and Clcn2-knockout mice or Mlc1-knockout zebrafish have provided fresh insight into the pathophysiology of MLC and further details about the molecular interactions between these three proteins. Additional studies have shown that GlialCAM/MLC1 also regulates other ion channels (TRPV4, VRAC) or transporters (Na+/K+-ATPase) in a not-understood manner. Furthermore, it has been shown that GlialCAM/MLC1 may influence signal transduction mechanisms, thereby affecting other proteins not related with transport such as the EGF receptor. Here, we offer a personal biochemical retrospective of the work that has been performed to gain knowledge of the pathophysiology of MLC, and we discuss future strategies that may be used to identify therapeutic solutions for MLC patients.

Femoral head and neck cysts are a common finding among patients with femoroacetabular impingement. However, their exact role in this pathology has not been yet clarified. We report herein the case of a 45-year-old male presenting with femoroacetabular impingement in which the treatment of a femoral simple bone cyst resolved the symptomatology.

Background Dentigerous cyst appears surrounding the crown of an included tooth. On the radiographic exam, a radiolucent rounded well-defined lesion can be observed. Material and methods This study reports a clinical case of a 34-years old man with a pericoronal radiolucent lesion associated to an impacted lower third molar with the presence of radiopaque material inside. The radiological differential diagnosis was calcifying odontogenic tumor, adenomatoid odontogenic tumor and dentigerous cyst. The impacted third molar was removed and the lesion was sent for the histopathological exam. Results The histopathological diagnosis was dentigerous cyst with capsular calcifications. Specifically, parietal calcifications on its connective wall and a piece of cemento-osseous tissue inside. Conclusions Non-neoplastic lesions such as dentigerous cysts could develop radiopacities inside the radiolucent pericoronal area. Key words:Dentigerous cyst, calcifications, third molar, differential diagnosis.

Objetivo: Os quistos sinoviais da articulação acromioclavicular (AC), podem ocorrer associadas à artrose AC ou como consequência da rotura massiva da coifa dos rotadores. Com o presente caso, os autores pretendem apresentar e discutir uma situação pouco frequente. Relato de caso: Homem de 81 anos, referenciado à consulta de Ortopedia por tumefação da região superior do ombro direito, indolor e de aumento progressivo nos últimos 2 anos. Avaliação clínica e radiológica compatível com volumoso quisto sinovial da acromioclavicular, associado a rotura massiva da coifa dos rotadores; submetido a tratamento cirúrgico com excisão marginal da lesão; a análise anatomopatológica confirmou o diagnóstico de quisto sinovial. Comentários: Os quistos sinoviais da articulação AC são entidades raras e pouco abordadas na literatura. A sua etiologia permanece por esclarecer ainda que um dos tipos descritos pareça estar associada à omatrose com rotura massiva da coifa dos rotadores (artropatia da coifa); nestes, a rotura da coifa permite a passagem de grandes quantidades de líquido sinovial para o espaço subacromial com formação de um volumoso quisto. Atendendo à sua raridade, o tratamento permanece controverso. O caso vem alertar para a ocorrência dos quistos da articulação AC, como apresentação invulgar de artropatia das coifa dos rotadores, discutindo a sua etiologia e abordagem terapêutica adequada. info:eu-repo/semantics/publishedVersion

Dentigerous cysts are one of the most common odontogenic cysts of the oral cavity. Odontogenic cysts can give rise to a variety of neoplasms. Carcinoma arising in a dentigerous cyst is extremely rare, with a review of literature showing near 30 cases. The present report describes 2 cases of primary intraosseous squamous cell carcinoma originated from a dentigerous cyst. The first one refers to a 57-year old female with a persistent lesion in the left retromolarregion and diagnosed with squamous cell carcinoma originated fromthe incomplete excision of the lower third molar follicle during its surgical extraction. The second case describes the case of an 18-year old male with an impacted upper canine with previous history of infection and swelling of the oral cavity. The histopathological study revealed the malignization of the follicle surrounding the dental crown. These two cases confirmed the importance of the histopathological study of all the tissue samples obtained from surgical procedures. Although the development of a malignant lesion from a dentigerous cyst is rare and its clinical-radiological features are apparently innocuous, this entity should be considered as a differential diagnosis. Key words:Dentigerous cyst, odontogenic cyst, squamous cell carcinoma, primary intraosseous squamous cell carcinoma, odontogenic carcinoma.

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The aim of this study was to systematically review scientific literature in orderto describe the characteristics and prognosis of malignant entities developing from odontogenic cysts. A search in Pubmed (MEDLINE) and Cochrane databases was conducted. The inclusion criteria were articles published in English related to the malignisation of odontogenic cysts in humans. The exclusion criteria were articles that do not specify the type of odontogenic cyst, malignisation of parakeratinised keratocysts, the presence of an ameloblastic carcinoma and metastasis from distant primary tumours. The selected articles were classified according to Strength of Recommendation Taxonomy criteria. Statistical analysis of the data was carried out using statistical package software SPSS version 22.0. From the 1,237 articles initially obtained, the authors included 3 case series and 45 case reports in the end. Descriptive analysis showed that men have a disposition for malignisation from odontogenic cysts and they frequently appear at the posterior mandible, with pain and swelling being the most frequent signs and symptoms. Follicular cysts were the entities that underwent the most malignant changes with well differentiated squamous cell carcinomas being the most prevalent type of malignancy. The real prognosis of this malignancy is not known because of the heterogeneity of available studies. Key words:Odontogenic cysts, squamous cell carcinoma, neoplastic cell transformation, oral cancer.

PURPOSE: To evaluate the effectiveness, recurrence rate, and complications of carbon-dioxide laser vaporization in the treatment of Bartholin's gland cysts. METHODS: A retrospective study including 127 patients with symptomatic Bartholin' gland cysts submitted to carbon-dioxide laser vaporization at our institution from January 2005 to June 2011. Patients with Bartholin's gland abscesses and those suspected of having neoplasia were excluded. All procedures were performed in an outpatient setting under local anaesthesia. Clinical records were reviewed for demographic characteristics, anatomic parameters, intraoperative and postoperative complications, and follow-up data. Data were stored and analyzed in Microsoft Excel® 2007 software. A descriptive statistical analysis was performed, and its results were expressed as frequency (percentage) or mean±standard deviation. Complication, recurrence, and cure rates were calculated. RESULTS: The mean age of the patients was 37.3±9.5 years-old (range from 18 to 61 years-old). Seventy percent (n=85) of them were multiparous. The most common symptom was pain and 47.2% (n=60) of patients had a history of previous medical and/or surgical treatment for Bartholin's gland abscesses. Mean cyst size was 2.7±0.9 cm. There were three (2.4%) cases of minor intraoperative bleeding. Overall, there were 17 (13.4%) recurrences within a mean of 14.6 months (range from 1 to 56 months): ten Bartholin's gland abscesses and seven recurrent cysts requiring reintervention. The cure rate after single laser treatment was 86.6%. Among the five patients with recurrent disease that had a second laser procedure, the cure rate was 100%. CONCLUSIONS: At this institution, carbon-dioxide laser vaporization seems to be a safe and effective procedure for the treatment of Bartholin's gland cysts. OBJETIVO: Avaliar a eficácia, a taxa de recorrência e as complicações da vaporização laser com CO2 no tratamento dos cistos da glândula de Bartholin. MÉTODOS: Estudo retrospectivo com 127 pacientes que apresentavam cistos sintomáticos da glândula de Bartholin submetidas à vaporização laser CO2 na nossa instituição de janeiro de 2005 a junho de 2011. Foram excluídas todas as pacientes com abcessos da glândula de Bartholin ou com suspeita de câncer. Todos os procedimentos foram realizados em regime ambulatorial, sob anestesia local. A coleta dos dados foi feita com base na consulta do processo clínico, tendo-se procedido à análise das características demográficas, dos parâmetros anatômicos, das complicações intra e pós-operatórias e dos dados de acompanhamento. Os dados foram armazenados e analisados no software Microsoft Excel® 2007, e os resultados foram apresentados como frequência (porcentagem) ou média±desvio padrão. As taxas de complicações, recorrência e cura foram calculadas. RESULTADOS: A idade média das pacientes foi de 37,3±9,5 anos (variando entre 18 e 61 anos). Setenta por cento (n=85) delas eram multíparas. A queixa mais frequente foi dor e 47,2% (n=60) das pacientes tinham antecedentes de tratamento médico e/ou cirúrgico por abcesso da glândula de Bartholin. A dimensão média dos cistos foi de 2,7±0,9 cm. Foram verificados três (2,4%) casos de hemorragia intraoperatória ligeira e 17 (13,4%) recorrências durante um período médio de 14,6 meses (variando entre 1 e 56 meses): dez abscessos da glândula de Bartholin e sete cistos recorrentes, que precisavam de uma nova intervenção cirúrgica. A taxa de cura após um único tratamento à laser foi de 86,6%. Dentre as cinco pacientes com doença recorrente que foram submetidas a um segundo procedimento com laser, a taxa de cura foi de 100%. CONCLUSÕES: Na presente instituição, a vaporização laser com CO2 parece ser uma opção terapêutica segura e eficaz no tratamento dos cistos da glândula de Bartholin.

espanolCasos clinicos: Presentamos una paciente de 43 anos con historia clinica de dolor sacro incapacitante 8/10 en la escala de EVA de 8 meses de evolucion. No se apreciaban alteraciones sensitivas ni perdida del control de esfinteres. Realizo consulta en multiples hospitales. Se le practicaron una tomografia computadorizada (TC) lumbar que puso de relieve un hemangioma en L5, una resonancia magnetica (RM) de pelvis en la que se evidencio rotura muscular grado I del gluteo mayor izquierdo y una lesion quistica en el sacro que se interpreto como quiste de Tarlov. Recibio tratamiento analgesico y antiinflamatorio sin mejoria. Se le realizaron dos bloqueos facetarios e incluso un bloqueo del musculo piriforme izquierdo, todo ello sin resultados. En nuestro centro se practico una RM lumbo-sacra que puso de relieve la lesion quistica de localizacion central y lateral derecha en canal espinal sacro a la altura de la transicion S2-S3. Era de alta senal en T2 y de baja senal en T1. Segun la clasificacion de Nabors correspondia a un meningocele intrasacro oculto. Discusion: El meningocele intrasacro oculto (quiste meningeo extradural tipo lB de la clasificacion de Nabors) es una entidad poco frecuente que se presenta generalmente entre la tercera y cuarta decada de la vida, como un cuadro clinico insidioso de dolor en extremidades inferiores, con o sin sintomas radiculares, disfuncion de esfinteres y alteraciones sensitivas. El tratamiento habitual de este tipo de lesiones es la intervencion quirurgica. En nuestro caso se realizo puncion y evacuacion del quiste sacro guiado por TC obteniendose unos 2 cc de un liquido sero-hematico. La evolucion posterior fue de mejoria notable del dolor sacro que paso a ser de 3/10 en la escala de EVA. En la revision de la literatura que hemos efectuado este es el primer caso en que se trata un meningocele intrasacro oculto doloroso mediante puncion evacuadora guiada por TC. EnglishCase reports: We report a 43-year old patient with a history of disabling pain sacrum 8/10 on the VAS of 8 months. No sensory disturbances were noted or loss of bowel control. Consultation conducted in multiple hospitals. She underwent a computed tomography (CT) lumbar that highlighted a hemangioma in L5, a magnetic resonance imaging (MRI) of the pelvis which showed muscle breakdown grade I of the left maximus gluteus, and a cystic lesion in the sacrum, which was interpreted as a Tarlov cyst. She received analgesic and anti-inflammatory treatment with no improvement. She also goes through two facet blocks and even a lock in the left piriformis, all without results. In our center we practised a lumbosacral MRI which highlighted a cystic lesion localized in central and right lateral sacral spinal canal at the level of S2-S3 transition. It was high signal on T2 and low signal on T1. Discussion: According to Nabors classification, this lesion corresponds to a hidden intrasacro meningocele. The hidden intrasacro meningocele (extradural meningeal cyst type classification LB Nabors) is a rare entity that usually develops between the third and fourth decade of life, as an insidious clinical lower extremity pain, with or without radicular symptoms, bowel dysfunction and sensory disturbances. The usual treatment of these lesions is surgical intervention. In our case puncture and evacuation guided by CT of the sacral cyst was performed, yielding about 2 cc of a sero-hematic fluid. The postoperative course was a remarkable improvement, and the sacral pain happened to be 3/10 on the VAS. In the literature that we have reviewed, this is the first case in which a hidden painful intrasacro meningocele is evacuated by CT-guided puncture.

Objectives: To determine the relative incidence of odontogenic cysts and to identify the main clinicopathological features among patients treated in the Oral Surgery Department of the Dental Clinic of the University of Barcelona (Spain). Study design: A retrospective observational study was made of 418 odontogenic cysts diagnosed in 380 patients included in the database of 1235 histopathological diagnoses. The subjects were treated in the Master degree program of Oral Surgery and Implantology of the University of Barcelona in the period 1997-2006. The following variables were recorded: gender, age, clinical characteristics of the lesions (size and location), radiological features, duration, treatment, complications and relapses. A descriptive analysis was made of the study variables, using the SPSS version 15.0. Results: The incidence of odontogenic cysts was 33.8%. The mean patient age at appearance of the lesion was 42 years (range 7-83). The cysts were slightly more prevalent in males (58.4%). The lesion size ranged from 2-60 mm, with a mean size of 18.4 mm. The most frequent diagnosis was radicular cyst (50.2%). The most common location of the odontogenic cysts was in the mandible (61.5%), particularly the lower third molar region (36.8%). Conclusions: The most frequently diagnosed lesion was the radicular cyst. Odontogenic cysts were seen to be slightly more prevalent in males, and showed a high mandibular incidence. Knowledge of the biological and histological behavior of odontogenic cysts and their frequency are key aspects for ensuring early detection and adequate treatment.

Epidermoid cysts are a rare entity in the oral cavity and are even less frequent in the floor of the mouth, representing less than 0.01% of all the cases. We present the case of a 3-year-old girl with a growth in the floor of the mouth with 2 months of evolution and without changes since it was discovered by her parents. The lesion was asymptomatic; it did not cause dysphagia, dyspnea, or any other alteration. A CT scan with contrast was done which revealed the location and exact size of the lesion, allowing an intraoral approach for its excision. The histological examination confirmed the clinical speculation of an epidermoid cyst.

Endometriosis, defined as the growth of endometrial tissue outside the uterus, is a common gynecologic condition affecting millions of women worldwide. It is an inflammatory, estrogen-dependent complex disorder, with broad symptomatic variability, pelvic pain, and infertility being the main characteristics. Ovarian endometriomas are frequently developed in women with endometriosis. Late diagnosis is one of the main problems of endometriosis; thus, it is important to identify biomarkers for early diagnosis. The aim of the present work is to evaluate the ecto-nucleotidases activities in the contents of endometriomas. These enzymes, through the regulation of extracellular ATP and adenosine levels, are key enzymes in inflammatory processes, and their expression has been previously characterized in human endometrium. To achieve our objective, the echo-guided aspirated fluids of endometriomas were analyzed by evaluating the ecto-nucleotidases activities and compared with simple cysts. Our results show that enzyme activities are quantifiable in the ovarian cysts aspirates and that endometriomas show significantly higher ecto-nucleotidases activities than simple cysts (5.5-fold increase for ATPase and 20-fold for ADPase), thus being possible candidates for new endometriosis biomarkers. Moreover, we demonstrate the presence of ecto-nucleotidases bearing exosomes in these fluids. These results add up to the knowledge of the physiopathologic mechanisms underlying endometriosis and, open up a promising new field of study.

Objective: To describe the clinical, radiological and histopathological features of lateral periodontal cysts among patients diagnosed in different centers (Vall d?Hebron General Hospital, Granollers General Hospital, the Teknon Medical Center, and the Master of Oral Surgery and Implantology of the University of Barcelona Dental School; Barcelona, Spain). Study design: A retrospective observational study was made of 11 lateral periodontal cysts, all of which were diagnosed following a thorough clinical examination, radiological study and posterior histological study. Results: The mean patient age was 37 years, and males predominated over females. The mean lesion size was 1.25 cm. A single relapse was recorded 7 years after removal of the initial lesion. All the cysts were surgically removed. Discussion and conclusions: Lateral periodontal cysts are very infrequent, and are characterized by the preserved vitality of the adjacent teeth. Identification of the lesion is initially based on the clinical findings, though histological study is required to confirm the diagnosis. The treatment of choice is the surgical removal, though occasional relapses have been documented.

Objectives: Nasopalatine duct cysts (NPDCs) are the most common developmental, epithelial and non-odontogenic cysts of the maxillae. The present study describes the clinicopathological characteristics of 22 NPDCs and discusses their etiology, incidence, treatment and prognosis, with a review of the literature on the subject. Study design: A retrospective observational study was made comprising a period of 36 years (1970-2006), and yielding a series of 22 patients with histopathological confirmation of NPDC. Surgical treatment was carried out under local anesthesia and comprised the dissection and removal of the cyst adopting a usually palatine approach, with the preparation of an enveloping flap from 1.4 to 2.4. Results: No statistically significant correlation was observed between the size of the lesion and patient age, although the size of the cyst differed according to patient gender, with a mean NPDC diameter of 16 mm in males and 12 mm in females. In no case did we observe root reabsorption or loss of vitality of the upper incisors following surgery. The X-ray image was rounded in 15 cases and heart-shaped in the remaining 7 cases. In the majority of cases panoramic X-rays and periapical and occlusal X-rays sufficed to identify the lesion, though computed tomography was used in cases of doubt. Conclusions: The etiology of NPDC is unclear. Simple surgical resection is recommended, followed by clinical and radiological control to ensure correct resolution of the case.

Dentigerous cysts, also known as follicular cysts, are a relatively common pathology in our field. They are associated with unerupted or semi-erupted teeth and are usually not related to supernumerary teeth. OBJECTIVE: To describe a dentigerous cyst case associated to a supernumerary tooth. CASE-REPORT: A large-sized dentigerous cyst is described, associated with a supernumerary tooth, affecting the whole maxillary anterior area. Appropriate treatment consists of performing root canals and a Partsch II procedure with a cystectomy, extracting the unerupted teeth, carrying out an apicoectomy and retro-filling the affected teeth. The defect is filled with a bone xenograft. Possible therapeutic alternatives and the connection between the dentigerous cysts and supernumerary teeth are considered in the discussion.

Summary Intraventricular schwannoma is an exceedingly rare tumour with only 6 cases described in the literature. One case of a cystic intraventricular schwannoma operated on at our Institution is analized and the other cases reported in the literature are reviewed. Complete removal was achieved and no reccurrence was noted after a follow-up period of 10 years. Intraventricular schwannomas are rare tumours that are amenable to complete surgical removal, having a good prognosis without the need of adjuvant therapy.

Los huesos maxilares constituyen asiento de una gran variedad de quistes y neoplasias que pueden ser de difícil diagnóstico. De entre todos los procesos tumorales que se dan en el territorio maxilofacial, los quistes son de gran importancia debido a la frecuencia de su presentación. Los quistes maxilares tienen distinto origen y comportamiento clínico. A partir de la clasificación de la OMS de 1992, esta revisión estudia las características clínicas, radiográficas y epidemiológicas de los quistes del desarrollo odontógenos. Una adecuada exploración clínica y radiográfica por parte del odontólogo es suficiente para alcanzar un diagnóstico de presunción. Las consideraciones clínicas y terapéuticas de cada uno de estos quistes son variables, por lo que es necesario conocer el comportamiento epidemiológico de ellos. El diagnóstico de presunción, el tamaño de la lesión y la relación de esta con estructuras anatómicas vecinas condicionará el tipo de tratamiento. El diagnóstico definitivo lo dictaminará el análisis anatomopatológico.

The squamous odontogenic tumour is a rare benign neoplasm whose aetiology remains unknown. It usually appears in the jaw and its origin could be related to the ephitelial remnants of Malassez. Histologically comprises numerous islets of squamous, non-keratinized, well-differentiated and rounded epithelial cells a fibrous stroma without signs of atypical cells. There is a non-neoplastic lesion with the same histological pattern than the squamous odontogenic tumour. This entity is characterized by squamous odontogenic tumour proliferations isolated into the cyst wall of an odontogenic cyst. It is rare and has a benign behavior. It has been suggested that these epithelial proliferations could be the former expression of the neoplastic form. It is very important to carry out clinical and radiological controls periodically. So far it has not been documented any change towards a squamous odontogenic tumour nor toward malignancy in a squamous odontogenic tumour like proliferation. Key words:Radicular cyst, squamous odontogenic tumour.

A 61-year-old woman was followed for multifocal motor neuropathy (MMN) with conduction block since young adulthood. She had bilateral clinical and neurophysiologic involvement of both median and ulnar nerves, as also the right peroneal nerve. In a recent reevaluation, we decided to complete her investigation with a brachial plexus magnetic resonance imaging (MRI) that, besides diffuse thickening of the right brachial plexus trunks, showed a round hyperintense cyst that compressed several branches distally (Figure). Brachial plexus MRI may be important [...]

OBJETIVO: Avaliar a eficácia, a taxa de recorrência e as complicações da vaporização laser com CO2 no tratamento dos cistos da glândula de Bartholin. MÉTODOS: Estudo retrospectivo com 127 pacientes que apresentavam cistos sintomáticos da glândula de Bartholin submetidas à vaporização laser CO2 na nossa instituição de janeiro de 2005 a junho de 2011. Foram excluídas todas as pacientes com abcessos da glândula de Bartholin ou com suspeita de câncer. Todos os procedimentos foram realizados em regime ambulatorial, sob anestesia local. A coleta dos dados foi feita com base na consulta do processo clínico, tendo-se procedido à análise das características demográficas, dos parâmetros anatômicos, das complicações intra e pós-operatórias e dos dados de acompanhamento. Os dados foram armazenados e analisados no software Microsoft Excel® 2007, e os resultados foram apresentados como frequência (porcentagem) ou média±desvio padrão. As taxas de complicações, recorrência e cura foram calculadas. RESULTADOS: A idade média das pacientes foi de 37,3±9,5 anos (variando entre 18 e 61 anos). Setenta por cento(n=85) delas eram multíparas. A queixa mais frequente foi dor e 47,2% (n=60) das pacientes tinham antecedentes de tratamento médico e/ou cirúrgico por abcesso da glândula de Bartholin. A dimensão média dos cistos foi de 2,7±0,9 cm. Foram verificados três (2,4%) casos de hemorragia intraoperatória ligeira e 17 (13,4%) recorrências durante um período médio de 14,6 meses (variando entre 1 e 56 meses): dez abscessos da glândula de Bartholin e sete cistos recorrentes, que precisavam de uma nova intervenção cirúrgica. A taxa de cura após um único tratamento à laser foi de 86,6%. Dentre as cinco pacientes com doença recorrente que foram submetidas a um segundo procedimento com laser, a taxa de cura foi de 100%. CONCLUSÕES: Na presente instituição, a vaporização laser com CO2 parece ser uma opção terapêutica segura e eficaz no tratamento dos cistos da glândula de Bartholin.

Submitted by Andréa Medeiros (andrea.medeiros@cespu.pt) on 2016-11-24T11:56:29Z No. of bitstreams: 1 Filipa_Fernandes_relat _estagio.pdf: 971804 bytes, checksum: b58eed79fa67b34bc06c9d1d148cfbe5 (MD5) Made available in DSpace on 2016-11-24T11:56:29Z (GMT). No. of bitstreams: 1 Filipa_Fernandes_relat _estagio.pdf: 971804 bytes, checksum: b58eed79fa67b34bc06c9d1d148cfbe5 (MD5) Previous issue date: 2011

With the recent technical improvement in echocardiography imaging (second harmonics) the number of interatrial septum aneurysms (ASA) increased and are easily recognized. We assist to an overdiagnosing number of cases and diagnostic criteria emerged to face this problem. In the great majority of the cases ASA are small and inoffensive, but as ASA is considered a risk factor for cardioembolism when associated with persistence of foramen oval (PFO), an examination by transesophageal echocardiography (TEE) for exclusion of PFO makes the sense and is a common testing in patients with cryptogenic stroke. Besides these frequent ASA, other forms exist; the authors describe two cases of uncommon and huge ASA, one mimicking a right atrial tumor and the other a quistic, hipoechoic mass. The first case was associated with mitral stenosis and was submitted to surgery and the second was closed with an Amplatzer occluder device usually used in atrial septal defect (ASD).

Submitted by Dulce Barreto (mdulce.barreto@chlc.min-saude.pt) on 2014-02-21T13:37:32Z No. of bitstreams: 1 Eurorad 2010_8360.pdf: 121047 bytes, checksum: b48ca77d6948abcc410fad1c06454635 (MD5) Made available in DSpace on 2014-02-21T13:37:32Z (GMT). No. of bitstreams: 1 Eurorad 2010_8360.pdf: 121047 bytes, checksum: b48ca77d6948abcc410fad1c06454635 (MD5) Previous issue date: 2010

Objetivos: conocer la incidencia relativa de los quistes odontogénicos, así como identificar sus características clínicopatológicas más relevantes en pacientes tratados en el Servicio de Cirugía Bucal de la Clínica Odontológica de la Universidad de Barcelona. Diseño del estudio: se realizó un estudio restrospectivo observacional de 418 casos diagnosticados de quiste odontogénico en 380 pacientes incluidos en el archivo de 1.235 diagnósticos anatomopatológicos de los pacientes tratados en el Máster de Cirugía Bucal e Implantología Bucofacial de la Universidad de Barcelona entre los años 1997-2006. Las variables recogidas fueron: sexo, edad, características clínicas de la lesión (tamaño y localización), características radiológicas, tiempo de evolución, tratamiento, complicaciones y recidivas. Se efectuó un estudio descriptivo de las variables recogidas utilizando el SPSS versión 15.0. Resultados: la incidencia de los quistes odontogénicos fue del 33, 8%. La edad media de aparición fue de 42 años con un rango comprendido entre los 7 y 83 años. Hubo una ligera predilección por el sexo masculino (58,4%). El tamaño de la lesión osciló entre 2 y 60 mm con una media de 18,4 mm. La entidad más frecuentemente diagnosticada fue el quiste radicular con un 50,2%. La localización más frecuente de los quistes odontogénicos fue la mandíbula (61,5%), especialmente la región del tercer molar inferior con un 36,8% de los casos. Conclusiones: la entidad más frecuentemente diagnosticada fue el quiste radicular. Los quistes odontogénicos mostraron una mayor predilección por el sexo masculino y una elevada incidencia mandibular. El conocimiento de la conducta biológica e histológica de los quistes odontogénicos y la frecuencia de aparición de estas lesiones son aspectos fundamentales para promover su detección precoz y el tratamiento adecuado.

Submitted by Ana Quininha (ana.quininha@chlc.min-saude.pt) on 2011-06-22T12:43:10Z No. of bitstreams: 1 RPC 2009 655.pdf: 554356 bytes, checksum: 07ff70f48837cec82f20927e323ff9ca (MD5) Made available in DSpace on 2011-06-22T12:43:10Z (GMT). No. of bitstreams: 1 RPC 2009 655.pdf: 554356 bytes, checksum: 07ff70f48837cec82f20927e323ff9ca (MD5) Previous issue date: 2009

With the recent technical improvement in echocardiography imaging (second harmonics) the number of interatrial septum aneurysms (ASA) increased and are easily recognized. We assist to an overdiagnosing number of cases and diagnostic criteria emerged to face this problem. In the great majority of the cases ASA are small and inoffensive, but as ASA is considered a risk factor for cardioembolism when associated with persistence of foramen oval (PFO), an examination by transesophageal echocardiography (TEE) for exclusion of PFO makes the sense and is a common testing in patients with cryptogenic stroke. Besides these frequent ASA, other forms exist; the authors describe two cases of uncommon and huge ASA, one mimicking a right atrial tumor and the other a quistic, hipoechoic mass. The first case was associated with mitral stenosis and was submitted to surgery and the second was closed with an Amplatzer occluder device usually used in atrial septal defect (ASD).

A displasia quística testicular é uma patologia benigna e rara, frequentemente associada a outras anomalias génito-urinárias, que se apresenta na infância sobretudo com aumento do volume escrotal, fazendo diagnóstico diferencial com situações neoplásicas e inflamatórias do testículo. Embora classicamente considerada indicação para orquidectomia, não parece haver qualquer potencial maligno, pelo que se pode argumentar uma abordagem conservadora. No entanto é importante confirmar o diagnóstico e manter vigilância para precaver a atrofia do parênquima testicular. Os autores apresentam o caso clínico de um doente com antecedentes de agenésia renal esquerda e megauretero obstructivo direito, submetido a orquidectomia no contexto de displasia quística testicular esquerda com atrofia importante do parênquima.

Objective: To describe the clinical and radiological characteristics, and surgical findings of traumatic bone cysts. Study Design: A retrospective observational study was made of 21 traumatic bone cysts. The diagnosis was based on the anamnesis, clinical examination, and complementary tests. Panoramic and periapical X-rays were obtained in all cases, together with computed tomography as decided by the surgeon. A descriptive statistical analysis was made of the study variables using the SPSS v12.0 for Windows. Results: There was a clear female predominance (14:7). The mean age was 26.5 years (range 8-45 years). The cysts in all cases constituted casual findings during routine radiological exploration. In those cases where computed tomographic images were available, preservation of the vestibular and lingual cortical layers was observed. Five of the 21 patients (23.8%) reported a clear antecedent of traumatism in the affected zone. All the lesions were subjected to surgery, and the cavities were found to be vacant in 90.5% of the cases. In only two patients were vascular contents seen within the cavity. Two of the patients presented postoperative paresthesia of the inferior dental nerve that subsided within two weeks. The 19 patients in whom adequate postoperative follow-up proved possible all showed complete bone healing. Conclusions: Traumatic bone cysts were a casual finding. During the surgery, most cases showed to be vacant cavity without an ephitelial lining. Careful curettage of the lesion favors progressive bone regeneration, offering a good prognosis and an almost negligible relapse rate. Other treatment options only would be justified in cases of relapse.

Objetivo: describir las características clínicas, radiológicas y los hallazgos quirúrgicos del quiste óseo traumático. Diseño del estudio: estudio retrospectivo observacional de 21 casos de quiste óseo traumático. El diagnóstico se basó en los datos obtenidos mediante la anamnesis y la exploración clínica así como en las pruebas complementarias pertinentes. Se hicieron ortopantomografías y radiografías periapicales a todos los pacientes. Según el criterio del cirujano, se realizaron de forma adicional tomografías computadorizadas. Se efectuó un análisis estadístico descriptivo de las variables con el Software SPSS v12.0 para Windows. Resultados: hubo una clara predilección por el sexo femenino (14:7). La edad media fue de 26,5 años (con un rango entre los 8 y 45 años). Esta entidad fue diagnosticada siempre de forma casual tras una exploración radiológica de rutina. En los casos que disponíamos de tomografía computadorizada se visualizó la conservación de las corticales vestibular y lingual. Cinco de los 21 pacientes (23,8%) reconocieron un antecedente traumático claro en la zona afectada. Dado que todos los casos fueron intervenidos quirúrgicamente, se pudo observar que las cavidades estaban vacías en el 90,5% de los casos, ya que solamente en 2 pacientes se observó contenido vascular en el interior de la cavidad. Dos de los pacientes presentaron una parestesia postoperatoria del nervio dentario inferior que remitió en 2 semanas. Los 19 pacientes que tuvieron un seguimiento postoperatorio adecuado, presentaron una curación ósea completa. Conclusiones: el quiste óseo traumático fue un hallazgo casual. Durante la cirugía se observó, en la mayoría de los casos, una cavidad vacía y sin recubrimiento epitelial. El curetaje meticuloso de la lesión favorece una regeneración ósea progresiva permitiendo un buen pronóstico y una tasa de recidivas casi nula, por lo que un tratamiento distinto estaría justificado sólo en los casos que recidiven.

Objetivos: el quiste del conducto nasopalatino (QCNP) es el quiste del desarrollo, epitelial y no odontogénico más frecuente de los maxilares. El propósito de nuestro estudio es presentar las características clínico-patológicas del QCNP, discutir su etiología, incidencia, tratamiento y pronóstico, y revisar la literatura existente. Diseño del estudio: se realizó un estudio observacional retrospectivo durante un periodo de 36 años (1970-2006), obteniendo una serie de 22 pacientes a los que el informe de anatomía patológica había confirmado el diagnóstico de QCNP. El procedimiento quirúrgico se efectuó bajo anestesia local y consistió en la disección y exéresis del quiste mediante abordaje habitualmente palatino, preparando un colgajo envolvente de 1.4 a 2.4. Resultados: no se observó correlación estadísticamente significativa entre el tamaño de la lesión y la edad del paciente, aunque el tamaño del quiste fue diferente en función del sexo: el diámetro medio de los QCNPs en los varones fue de 16 mm y en las mujeres de 12 mm. Nunca se observó reabsorción radicular ni pérdida de vitalidad de los incisivos superiores después de la intervención quirúrgica. La imagen radiográfica era redondeada en 15 casos y en forma de corazón de naipes en los 7 restantes. En la mayoría de los casos fue suficiente la ortopantomografía y las radiografías periapicales y oclusales, pero en caso de duda se efectuó una tomografía computadorizada. Conclusiones: el QCNP tiene una etiología incierta. Se recomienda la exéresis quirúrgica simple y un control clínico y radiológico posterior que asegure la resolución correcta del caso.

A pieloureteriste cística é uma patologia benigna rara, caracterizada pela presença de cistos suburoteliais. A persistência de estímulos irritativos a nível do urotélio e a subsequente resposta inflamatória crónica foram implicadas no seu desenvolvimento. Este distúrbio, cujo diagnóstico decorre de um achado radiológico incidental típico, caracterizado pela presença de múltiplas imagens de subtracção ao longo da árvore pieloureteral, encontra-se frequentemente associado a patologia litiásica e infecciosa do tracto urinário. No entanto, outras causas para estes achados característicos devem ser considerados, particularmente os tumores uroteliais e a tuberculose genitourinária. A propósito de um caso de pieloureterite cística diagnosticado numa doente em choque séptico, revemos as suas principais características clínicas e estratégias terapêuticas.

The cervical cysts hove a behaviour and prognostic that vary according to its source, time of evolution, nature and dimensions.One should consider metastasis of pharyngeal, laryngeal, thyroid, parathyroid, lungs and salivary glands neoplasms.Any swelling in retro and parapharyngeal spaces can cause digestive and airway compromise.Thyroid cysts spontaneous haematomas cases ore rare.The authors describe o case report of a young woman with a sudden set of painless cervical tumefaction causing dyspnea, related to a thyroid node which is exclusively cystic, with sero-hemathic filling, as well as the applied treatment.ln this work it is presented o retrospective of cervical masses cases that occured in lhe Navy Hospital from 2001 to 2005.There were no records of thyroid haematomas within this period. As tumefacções cervicais quísticas têm comportamento e prognóstico que variam consoante o suo origem, tempo de evolução, natureza e dimensões.Deve-se excluir os metástases considerando como prováveis sedes de neoplasia as estruturas da faringe, laringe, tiroide, paratiroides, pulmões e glândulassalivares.Qualquer tumefacção nos espaços retro ou parafaríngeo pode ocasionar obstrução do tracto digestivo superior ou compressão traqueal.A hemorragia, devido à sua evolução rápida, pode comprometer a vida do doente.Casos de hemorragia espontâneo em quistos tiroideus são raros.Os autores apresentam o caso clínico de uma jovem com instalação súbita de tumefacção cervical indolor condicionando dispneia, em relação com nódulo da tiroide exclusivamente quístico, de conteúdo sero-hemático, bem como o tratamento instituído.Neste trabalho apresenta-se uma retrospectiva dos casos de massas cervicais que ocorreram no Hospital do Marinho (HM) nos anos de 2001 o 2005 não havendo registos de hematomas tiroideus neste período.

Podeu consultar la versió en castellà a http://hdl.handle.net/2445/117306, Objective: to describe the clinical and radiological characteristics of patients with Stafne bone cavity. Study design: a retrospective, observational study of 11 cases of Stafne bone cavity. After finding an imagine compatible with Stafne bone cavity in the Orthopantomograph® of 11 patients, a sialography of the mandibular gland was made in 3 cases, computerized tomography (CT) in 6 cases, and in 4 cases surgical intervention to confirm the diagnosis. Results: the average age was 51.5 years, predominantly males. The entity was diagnosed incidentally during a routine radiology in all cases. The sialography revealed glandular tissue within the defect, and the CT demonstrated the conservation of the lingual cortical and the peripheral origin of the lesion. Glandular tissue was found within the lesions of two of the patients who underwent surgery, and in the other two the cavity was empty. No progressive changes were found in any of the 11 cases. Conclusions: Stafne bone cavity was an incidental finding, presenting no evolutionary changes, and as such conservatory therapy based on periodic controls was indicated. Currently, complementary techniques such as CT are sufficient to establish a certain diagnosis.

Podeu consultar la versió en anglès a: http://hdl.handle.net/2445/48487, Objectivo: Describir las características clínicas y radiológicas de pacientes con cavidad de Stafne. Diseño del estudio: Estudio retrospectivo observacional de 11 casos de cavidad de Stafne. Tras hallar en la ortopantomografía de 11 pacientes una imagen compatible con cavidad de Stafne, se solicitaron sialografía de la glándula submaxilar en 3 casos, tomografía computadorizada (TC) en 6 pacientes y se realizó una intervención quirúrgica en 4 casos para obtener un diagnóstico de certeza. Resultados: La edad media fue de 51.5 años y el sexo masculino fue predominante. Esta entidad fue diagnosticada siempre de forma casual tras una exploración radiológica de rutina. Las sialografías permitieron observar tejido glandular dentro del defecto y con la TC se visualizó la conservación de la cortical lingual y el origen periférico de la lesión. Dos pacientes intervenidos quirúrgicamente tenían tejido glandular en el interior de la lesión y 2 tenían la cavidad vacía. No se observaron cambios evolutivos en ninguno de los 11 casos. Conclusiones: La cavidad de Stafne fue un hallazgo radiológico casual que no presentó cambios evolutivos estando así indicada una opción terapéutica conservadora basada en controles periódicos. Actualmente, las pruebas complementarias como la TC son suficientes para establecer un diagnóstico de certeza.