50 results on '"Quiros, Jose Ramon"'
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2. Healthy lifestyle and the risk of pancreatic cancer in the EPIC study
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Naudin, Sabine, Viallon, Vivian, Hashim, Dana, Freisling, Heinz, Jenab, Mazda, Weiderpass, Elisabete, Perrier, Flavie, McKenzie, Fiona, Bueno-de-Mesquita, H Bas, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Mancini, Francesca R., Rebours, Vinciane, Boutron-Ruault, Marie-Christine, Katzke, Verena, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Peppa, Eleni, Karakatsani, Anna, Trichopoulou, Antonia, Pala, Valeria, Masala, Giovana, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M., van Gils, Carla H., Rylander, Charlotta, Borch, Kristin Benjaminsen, López, María Dolores Chirlaque, Sánchez, Maria-Jose, Ardanaz, Eva, Quirós, José Ramón, Exezarreta, Pilar Amiano, Sund, Malin, Drake, Isabel, Regnér, Sara, Travis, Ruth C., Wareham, Nick, Aune, Dagfinn, Riboli, Elio, Gunter, Marc J., Duell, Eric J., Brennan, Paul, and Ferrari, Pietro
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- 2020
3. Meat and haem iron intake in relation to glioma in the European Prospective Investigation into Cancer and Nutrition study
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Ward, Heather A., Gayle, Alicia, Jakszyn, Paula, Merritt, Melissa, Melin, Beatrice, Freisling, Heinz, Weiderpass, Elisabete, Tjonneland, Anne, Olsen, Anja, Dahm, Christina C., Overvad, Kim, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Kyrozis, Andreas, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Bueno-de-Mesquita, Bas, Peeters, Petra H., Quirós, José Ramón, Agudo, Antonio, Rodriguez-Barranco, Miguel, Larrañaga, Nerea, Huerta, José M., Barricarte, Aurelio, Sonestedt, Emily, Drake, Isabel, Sandström, Maria, Travis, Ruth C., Ferrari, Pietro, Riboli, Elio, and Cross, Amanda J.
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- 2018
4. Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies
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Nimptsch, Katharina, Song, Mingyang, Aleksandrova, Krasimira, Katsoulis, Michail, Freisling, Heinz, Jenab, Mazda, Gunter, Marc J., Tsilidis, Konstantinos K., Weiderpass, Elisabete, Bueno-De-Mesquita, H. Bas, Chong, Dawn Q., Jensen, Majken K., Wu, Chunsen, Overvad, Kim, Kühn, Tilman, Barrdahl, Myrto, Melander, Olle, Jirström, Karin, Peeters, Petra H., Sieri, Sabina, Panico, Salvatore, Cross, Amanda J., Riboli, Elio, Van Guelpen, Bethany, Myte, Robin, Huerta, José María, Rodriguez-Barranco, Miguel, Quirós, José Ramón, Dorronsoro, Miren, Tjønneland, Anne, Olsen, Anja, Travis, Ruth, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Severi, Gianluca, Bonet, Catalina, Palli, Domenico, Janke, Jürgen, Lee, Young-Ae, Boeing, Heiner, Giovannucci, Edward L., Ogino, Shuji, Fuchs, Charles S., Rimm, Eric, Wu, Kana, Chan, Andrew T., and Pischon, Tobias
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- 2017
5. Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study
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Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A., Ward, Heather A., Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M., Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H., Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria-Dolores, Travier, Noémie, Travis, Ruth C., Sanchez, Maria-Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, and Vineis, Paolo
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- 2016
6. Validity of self-reported prevalent cases of stroke and acute myocardial infarction in the Spanish cohort of the EPIC study
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Machón, Monica, Arriola, Larraitz, Larrañaga, Nerea, Amiano, Pilar, Moreno-Iribas, Concepción, Agudo, Antonio, Ardanaz, Eva, Barricarte, Aurelio, Buckland, Genevieve, Chirlaque, MaDolores, Gavrila, Diana, Huerta, José María, Martínez, Carmen, Molina, Esther, Navarro, Carmen, Quiros, José Ramón, Rodríguez, Laudina, Sanchez, María José, González, Carlos Alberto, and Dorronsoro, Miren
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- 2013
7. Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study
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Duell, Eric J., Lujan-Barroso, Leila, Sala, Núria, McElyea, Samantha Deitz, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Weiderpass, Elisabete, Busund, Lill-Tove, Moi, Line, Muller, David, Vineis, Paolo, Aune, Dagfinn, Matullo, Giuseppe, Naccarati, Alessio, Panico, Salvatore, Tagliabue, Giovanna, Tumino, Rosario, Palli, Domenico, Kaaks, Rudolf, Katzke, Verena A., Boeing, Heiner, Bueno-de-Mesquita, B(as) H., Peeters, Petra H., Trichopoulou, Antonia, Lagiou, Pagona, Kotanidou, Anastasia, Travis, Ruth C., Wareham, Nick, Khaw, Kay-Tee, Quiros, Jose Ramon, Rodríguez-Barranco, Miguel, Dorronsoro, Miren, Chirlaque, María-Dolores, Ardanaz, Eva, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Brennan, Paul, Gunter, Marc, Scelo, Ghislaine, Cote, Greg, Sherman, Stuart, and Korc, Murray
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- 2017
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8. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition
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Ros, Martine M, Bueno-de-Mesquita, H Bas, Kampman, Ellen, Aben, Katja KH, Büchner, Frederike L, Jansen, Eugene HJM, van Gils, Carla H, Egevad, Lars, Overvad, Kim, Tjønneland, Anne, Roswall, Nina, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Perquier, Florence, Kaaks, Rudolf, Chang-Claude, Jenny, Weikert, Steffen, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Dilis, Vardis, Palli, Domenico, Pala, Valeria, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Peeters, Petra HM, Gram, Inger T, Skeie, Guri, Huerta, José María, Barricarte, Aurelio, Quirós, José Ramón, Sánchez, María José, Buckland, Genevieve, Larrañaga, Nerea, Ehrnström, Roy, Wallström, Peter, Ljungberg, Börje, Hallmans, Göran, Key, Timothy J, Allen, Naomi E, Khaw, Kay-Tee, Wareham, Nick, Brennan, Paul, Riboli, Elio, and Kiemeney, Lambertus A
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- 2012
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9. Association between different obesity measures and the risk of stroke in the EPIC Spanish cohort
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Abete, Itziar, Arriola, Larraitz, Etxezarreta, Nerea, Mozo, Imanol, Moreno-Iribas, Conchi, Amiano, Pilar, Egüés, Nerea, Goyenechea, Estibaliz, de Munain, Adolfo Lopez, Martinez, Maite, Travier, Noemi, Navarro, Carmen, Chirlaque, Maria-Dolores, Tormo, Maria-Jose, Gavrila, Diana, Huerta, Jose Maria, Sánchez, María-José, Molina-Montes, Esther, Requena, Mar, Jiménez-Hernández, Maria-Dolores, Ardanaz, Eva, Barricarte, Aurelio, Quiros, Jose Ramon, Rodriguez, Laudina, and Dorronsoro, Miren
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- 2015
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10. Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study
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Romaguera, Dora, Vergnaud, Anne-Claire, Peeters, Petra H, van Gils, Carla H, Chan, Doris SM, Ferrari, Pietro, Romieu, Isabelle, Jenab, Mazda, Slimani, Nadia, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Perquier, Florence, Kaaks, Rudolf, Teucher, Birgit, Boeing, Heiner, von Rüsten, Anne, Tjønneland, Anne, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Quirós, José Ramón, Gonzalez, Carlos A, Sánchez, María José, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas J, Crowe, Francesca L, Key, Timothy J, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Masala, Giovanna, Vineis, Paolo, Tumino, Rosario, Sieri, Sabina, Panico, Salvatore, May, Anne M, Bueno-de-Mesquita, H Bas, Büchner, Frederike L, Wirfält, Elisabet, Manjer, Jonas, Johansson, Ingegerd, Hallmans, Göran, Skeie, Guri, Benjaminsen Borch, Kristin, Parr, Christine L, Riboli, Elio, and Norat, Teresa
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- 2012
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11. The prospective association between total and type of fish intake and type 2 diabetes in 8 European countries: EPIC-InterAct Study
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Patel, Pinal S, Forouhi, Nita G, Kuijsten, Anneleen, Schulze, Matthias B, van Woudenbergh, Geertruida J, Ardanaz, Eva, Amiano, Pilar, Arriola, Larraitz, Balkau, Beverley, Barricarte, Aurelio, Beulens, Joline WJ, Boeing, Heiner, Buijsse, Brian, Crowe, Francesca L, de Lauzon-Guillan, Blandine, Fagherazzi, Guy, Franks, Paul W, Gonzalez, Carlos, Grioni, Sara, Halkjaer, Jytte, Huerta, José María, Key, Timothy J, Kühn, Tilman, Masala, Giovanna, Nilsson, Peter, Overvad, Kim, Panico, Salvatore, Quirós, Jose Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Sánchez, María-José, Schmidt, Erik B, Slimani, Nadia, Spijkerman, Annemieke MW, Teucher, Birgit, Tjonneland, Anne, Tormo, Maria-Jose, Tumino, Rosario, van der A, Daphne L, van der Schouw, Yvonne T, Sharp, Stephen J, Langenberg, Claudia, Feskens, Edith JM, Riboli, Elio, and Wareham, Nicholas J
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- 2012
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12. Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
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Chajès, Véronique, Jenab, Mazda, Romieu, Isabelle, Ferrari, Pietro, Dahm, Christina C, Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Engel, Pierre, Teucher, Birgit, Kaaks, Rudolf, Floegel, Anna, Boeing, Heiner, Trichopoulou, Antonia, Dilis, Vardis, Karapetyan, Tina, Mattiello, Amalia, Tumino, Rosario, Grioni, Sara, Palli, Domenico, Vineis, Paolo, Bueno-de-Mesquita, H Bas, Numans, Mattijs E, Peeters, Petra HM, Lund, Eiliv, Navarro, Carmen, Quirós, Jose Ramón, Sánchez-Cantalejo, Emilio, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Regnér, Sara, Sonestedt, Emily, Wirfält, Elisabet, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E, Crowe, Francesca L, Rinaldi, Sabina, Slimani, Nadia, Carneiro, Fatima, Riboli, Elio, and González, Carlos A
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- 2011
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13. Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition
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Ose, Jennifer, Fortner, Renée T., Rinaldi, Sabina, Schock, Helena, Overvad, Kim, Tjonneland, Anne, Hansen, Louise, Dossus, Laure, Fournier, Agnes, Baglietto, Laura, Romieu, Isabelle, Kuhn, Elisabetta, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Quiros, Jose Ramon, Obón-Santacana, Mireia, Larrañaga, Nerea, Chirlaque, María-Dolores, Sánchez, María-José, Barricarte, Aurelio, Peeters, Petra H., Bueno-de-Mesquita, H. B(as), Onland-Moret, Charlotte N., Brändstedt, Jenny, Lundin, Eva, Idahl, Annika, Weiderpass, Elisabete, Gram, Inger T., Lund, Eiliv, Kaw, Kay-Tee, Travis, Ruth C., Merritt, Melissa A., Gunther, Marc J., Riboli, Elio, and Kaaks, Rudolf
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- 2015
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14. Development and validation of a lifestyle-based model for colorectal cancer risk prediction : the LiFeCRC score
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Aleksandrova, Krasimira, Reichmann, Robin, Kaaks, Rudolf, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Dahm, Christina C., Eriksen, Anne Kirstine, Tjonneland, Anne, Artaud, Fanny, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Husing, Anika, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Panico, Salvatore, Masala, Giovanna, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Elias, Sjoerd G., May, Anne M., Borch, Kristin B., Sandanger, Torkjel M., Skeie, Guri, Sanchez, Maria-Jose, Huerta, Jose Maria, Sala, Nuria, Gurrea, Aurelio Barricarte, Quiros, Jose Ramon, Amiano, Pilar, Berntsson, Jonna, Drake, Isabel, van Guelpen, Bethany, Harlid, Sophia, Key, Tim, Weiderpass, Elisabete, Aglago, Elom K., Cross, Amanda J., Tsilidis, Konstantinos K., Riboli, Elio, Gunter, Marc J., Aleksandrova, Krasimira, Reichmann, Robin, Kaaks, Rudolf, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Dahm, Christina C., Eriksen, Anne Kirstine, Tjonneland, Anne, Artaud, Fanny, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Husing, Anika, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Panico, Salvatore, Masala, Giovanna, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Elias, Sjoerd G., May, Anne M., Borch, Kristin B., Sandanger, Torkjel M., Skeie, Guri, Sanchez, Maria-Jose, Huerta, Jose Maria, Sala, Nuria, Gurrea, Aurelio Barricarte, Quiros, Jose Ramon, Amiano, Pilar, Berntsson, Jonna, Drake, Isabel, van Guelpen, Bethany, Harlid, Sophia, Key, Tim, Weiderpass, Elisabete, Aglago, Elom K., Cross, Amanda J., Tsilidis, Konstantinos K., Riboli, Elio, and Gunter, Marc J.
- Abstract
Background: Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral to screening and motivate behaviour change. We therefore developed and validated a lifestyle-based CRC risk prediction algorithm in an asymptomatic European population. Methods: The model was based on data from 255,482 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study aged 19 to 70 years who were free of cancer at study baseline (1992–2000) and were followed up to 31 September 2010. The model was validated in a sample comprising 74,403 participants selected among five EPIC centres. Over a median follow-up time of 15 years, there were 3645 and 981 colorectal cancer cases in the derivation and validation samples, respectively. Variable selection algorithms in Cox proportional hazard regression and random survival forest (RSF) were used to identify the best predictors among plausible predictor variables. Measures of discrimination and calibration were calculated in derivation and validation samples. To facilitate model communication, a nomogram and a web-based application were developed. Results: The final selection model included age, waist circumference, height, smoking, alcohol consumption, physical activity, vegetables, dairy products, processed meat, and sugar and confectionary. The risk score demonstrated good discrimination overall and in sex-specific models. Harrell’s C-index was 0.710 in the derivation cohort and 0.714 in the validation cohort. The model was well calibrated and showed strong agreement between predicted and observed risk. Random survival forest analysis suggested high model robustness. Beyond age, lifestyle data l
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- 2021
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15. Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: Etiological factors or risk markers?
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Lukanova, Annekatrin, Becker, Susen, Hüsing, Anika, Schock, Helena, Fedirko, Veronika, Trepo, Elisabeth, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Benetou, Vassiliki, Trichopoulos, Dimitrios, Nöthlings, Ute, Tjnneland, Anne, Overvad, Kim, Dossus, Laure, Teucher, Birgit, Boeing, Heiner, Aleksandrova, Krasimira, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, Bas H., Siersema, Peter D., Peeters, Petra H.M., Quiros, Jose Ramon, Duell, Eric J., Molina-Montes, Esther, Chirlaque, Maria-Dolores, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Lindkvist, Björn, Johansen, Dorthe, Werner, Mårten, Sund, Malin, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Travis, Ruth C., Rinaldi, Sabina, Romieu, Isabelle, Gunter, Marc J., Riboli, Elio, Jenab, Mazda, and Kaaks, Rudolf
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- 2014
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16. A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
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Papadimitriou, Nikos, Muller, David, van den Brandt, Piet A., Geybels, Milan, Patel, Chirag J., Gunter, Marc J., Lopez, David S., Key, Timothy J., Perez-Cornago, Aurora, Ferrari, Pietro, Vineis, Paolo, Weiderpass, Elisabete, Boeing, Heiner, Agudo, Antonio, Sanchez, Maria-Jose, Overvad, Kim, Kuehn, Tilman, Fortner, Renee T., Palli, Domenico, Drake, Isabel, Bjartell, Anders, Santiuste, Carmen, Bueno-de-Mesquita, Bas H., Krogh, Vittorio, Tjonneland, Anne, Lauritzen, Dorthe Furstrand, Gurrea, Aurelio Barricarte, Quiros, Jose Ramon, Stattin, Pär, Trichopoulou, Antonia, Martimianaki, Georgia, Karakatsani, Anna, Thysell, Elin, Johansson, Ingegerd, Ricceri, Fulvio, Tumino, Rosario, Larranaga, Nerea, Khaw, Kay Tee, Riboli, Elio, Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Papadimitriou, Nikos, Muller, David, van den Brandt, Piet A., Geybels, Milan, Patel, Chirag J., Gunter, Marc J., Lopez, David S., Key, Timothy J., Perez-Cornago, Aurora, Ferrari, Pietro, Vineis, Paolo, Weiderpass, Elisabete, Boeing, Heiner, Agudo, Antonio, Sanchez, Maria-Jose, Overvad, Kim, Kuehn, Tilman, Fortner, Renee T., Palli, Domenico, Drake, Isabel, Bjartell, Anders, Santiuste, Carmen, Bueno-de-Mesquita, Bas H., Krogh, Vittorio, Tjonneland, Anne, Lauritzen, Dorthe Furstrand, Gurrea, Aurelio Barricarte, Quiros, Jose Ramon, Stattin, Pär, Trichopoulou, Antonia, Martimianaki, Georgia, Karakatsani, Anna, Thysell, Elin, Johansson, Ingegerd, Ricceri, Fulvio, Tumino, Rosario, Larranaga, Nerea, Khaw, Kay Tee, Riboli, Elio, Tzoulaki, Ioanna, and Tsilidis, Konstantinos K.
- Abstract
Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature., From WoS: Early access - [The article] have been peer-reviewed and accepted for publication. The article content has been finalized, but it has not been assigned to an issue yet.
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- 2020
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17. Antibody Responses to Helicobacter pylori and Risk of Developing Colorectal Cancer in a European Cohort
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Butt, Julia, Jenab, Mazda, Pawlita, Michael, Tjonneland, Anne, Kyro, Cecilie, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Dong, Catherine, Kaaks, Rudolf, Kuhn, Tilman, Boeing, Heiner, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vermeulen, Roel, Gram, Inger T., Weiderpass, Elisabete, Borch, Kristin Benjaminsen, Quiros, Jose Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Santiuste, Carmen, Ardanaz, Eva, van Guelpen, Bethany, Harlid, Sophia, Imaz, Liher, Perez-Cornago, Aurora, Gunter, Marc J., Zouiouich, Semi, Park, Jin Young, Riboli, Elio, Cross, Amanda J., Heath, Alicia K., Waterboer, Tim, Hughes, David J., Butt, Julia, Jenab, Mazda, Pawlita, Michael, Tjonneland, Anne, Kyro, Cecilie, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Dong, Catherine, Kaaks, Rudolf, Kuhn, Tilman, Boeing, Heiner, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vermeulen, Roel, Gram, Inger T., Weiderpass, Elisabete, Borch, Kristin Benjaminsen, Quiros, Jose Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Santiuste, Carmen, Ardanaz, Eva, van Guelpen, Bethany, Harlid, Sophia, Imaz, Liher, Perez-Cornago, Aurora, Gunter, Marc J., Zouiouich, Semi, Park, Jin Young, Riboli, Elio, Cross, Amanda J., Heath, Alicia K., Waterboer, Tim, and Hughes, David J.
- Abstract
Background: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer development. However, prospective studies addressing H. pylori and colorectal cancer are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific seropositivity with odds of developing colorectal cancer. Results: Fifty-one percent of colorectal cancer cases were H. pylori seropositive compared with 44% of controls, resulting in an OR of 1.36 (95% CI, 1.00-1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by seropositivity to Helicobacter cysteine-rich protein C (HcpC; OR: 1.66; 95% CI, 1.19-2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34; 95% CI, 0.99-1.82), the latter being nonstatistically significant only in the fully adjusted model. Conclusions: In this prospective multicenter European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing colorectal cancer. Impact: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease colorectal cancer incidence.
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- 2020
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18. Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer
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Butt, Julia, Jenab, Mazda, Pawlita, Michael, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Mancini, Francesca Romana, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Palli, Domenico, Pala, Valeria Maria, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, van Gils, Carla H., Vermeulen, Roel C. H., Weiderpass, Elisabete, Quiros, Jose Ramon, Duell, Eric Jeffrey, Sanchez, Maria-Jose, Dorronsoro, Miren, Maria Huerta, Jose, Ardanaz, Eva, van Guelpen, Bethany, Harlid, Sophia, Perez-Cornago, Aurora, Gunter, Marc J., Murphy, Neil, Freisling, Heinz, Aune, Dagfinn, Waterboer, Tim, Hughes, David J., Butt, Julia, Jenab, Mazda, Pawlita, Michael, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Mancini, Francesca Romana, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Palli, Domenico, Pala, Valeria Maria, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, van Gils, Carla H., Vermeulen, Roel C. H., Weiderpass, Elisabete, Quiros, Jose Ramon, Duell, Eric Jeffrey, Sanchez, Maria-Jose, Dorronsoro, Miren, Maria Huerta, Jose, Ardanaz, Eva, van Guelpen, Bethany, Harlid, Sophia, Perez-Cornago, Aurora, Gunter, Marc J., Murphy, Neil, Freisling, Heinz, Aune, Dagfinn, Waterboer, Tim, and Hughes, David J.
- Abstract
Background: There is a lack of prospective data on the potential association of Fusobacterium nucleatum (F. nucleatum) and colorectal cancer risk. In this study, we assessed whether antibody responses to F. nucleatum are associated with colorectal cancer risk in prediagnostic serum samples in the European Prospective Investigation into Nutrition and Cancer (EPIC) cohort. Methods: We applied a multiplex serology assay to simultaneously measure antibody responses to 11 F. nucleatum antigens in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI). Results: We observed neither a statistically significant colorectal cancer risk association for antibodies to individual F. nucleatum proteins nor for combined positivity to any of the 11 proteins (OR, 0.81; 95% CI, 0.62–1.06). Conclusions: Antibody responses to F. nucleatum proteins in prediagnostic serum samples from a subset of colorectal cancer cases and matched controls within the EPIC study were not associated with colorectal cancer risk. Impact: Our findings in prospectively ascertained serum samples contradict the existing literature on the association of F. nucleatum with colorectal cancer risk. Future prospective studies, specifically detecting F. nucleatum in stool or tissue biopsies, are needed to complement our findings.
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- 2019
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19. Meat and haem iron intake in relation to glioma in the European Prospective Investigation into Cancer and Nutrition study
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Ward, Heather A. Gayle, Alicia Jakszyn, Paula Merritt, Melissa Melin, Beatrice Freisling, Heinz Weiderpass, Elisabete Tjonneland, Anne Olsen, Anja Dahm, Christina C. and Overvad, Kim Katzke, Verena Kuehn, Tilman Boeing, Heiner and Trichopoulou, Antonia Lagiou, Pagona Kyrozis, Andreas and Palli, Domenico Krogh, Vittorio Tumino, Rosario Ricceri, Fulvio Mattiello, Amalia Bueno-de-Mesquita, Bas Peeters, Petra H. Quiros, Jose Ramon Agudo, Antonio and Rodriguez-Barranco, Miguel Larranaga, Nerea Huerta, Jose M. and Barricarte, Aurelio Sonestedt, Emily Drake, Isabel and Sandstroem, Maria Travis, Ruth C. Ferrari, Pietro Riboli, Elio Cross, Amanda J.
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food and beverages - Abstract
Diets high in red or processed meat have been associated positively with some cancers, and several possible underlying mechanisms have been proposed, including iron-related pathways. However, the role of meat intake in adult glioma risk has yielded conflicting findings because of small sample sizes and heterogeneous tumour classifications. The aim of this study was to examine red meat, processed meat and iron intake in relation to glioma risk in the European Prospective Investigation into Cancer and Nutrition study. In this prospective cohort study, 408751 individuals from nine European countries completed demographic and dietary questionnaires at recruitment. Multivariable Cox proportional hazards models were used to examine intake of red meat, processed meat, total dietary iron and haem iron in relation to incident glioma. During an average follow-up of 14.1 years, 688 incident glioma cases were diagnosed. There was no evidence that any of the meat variables (red, processed meat or subtypes of meat) or iron (total or haem) were associated with glioma; results were unchanged when the first 2 years of follow-up were excluded. This study suggests that there is no association between meat or iron intake and adult glioma. This is the largest prospective analysis of meat and iron in relation to glioma and as such provides a substantial contribution to a limited and inconsistent literature.
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- 2018
20. Physical Sports Activity During Leisure Time and Dietary Intake of Foods and Nutrients in a Large Spanish Cohort.
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Tormo, Maria Jose, Navarro, Carmen, Chirlaque, Maria-Dolores, Barber, Xavier, Argilaga, Silvia, Agudo, Antonio, Amiano, Pilar, Barricarte, Aurelio, Beguiristain, Jose M., Dorronsoro, Miren, Gonzalez, Carlos Alberto, Martinez, Carmen, Quiros, Jose Ramon, and Rodriguez, Mauricio
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INGESTION ,NUTRITION ,VITAMINS ,LEISURE - Abstract
Focuses on the dietary pattern of foods and nutrients according to levels of vigorous leisure time physical activity. Use of a validated diet history questionnaire; Effect of intake of some foods and vitamins on physical activity; Measurement of anthropometric indices.
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- 2003
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21. Measured adiposity in relation to head and neck cancer risk in the European prospective investigation into cancer and nutrition
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Ward, Heather A., Wark, Petra A., Muller, David C., Steffen, Annika, Johansson, Mattias, Norat, Teresa, Gunter, Marc J., Overvad, Kim, Dahm, Christina C., Halkjær, Jytte, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Mesrine, Sylvie, Brennan, Paul, Freisling, Heinz, Li, Kuanrong, Kaaks, Rudolf, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salavatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Palli, Domenico, Peeters, Petra H.M., Bueno-De-Mesquita, H. Bas, Weiderpass, Elisabete, Agudo, Antonio, Quiros, Jose Ramon, Larranaga, Nerea, Ardanaz, Eva, Huerta, Jose María, Sanchez, María Jose, Laurell, Goran, Johansson, Ingegerd, Westin, Ulla, Wallstrom, Peter, Bradbury, Kathryn E., Wareham, Nicholas J., Khaw, Kay Tee, Pearson, Clare, Boeing, Heiner, Riboli, Elio, Ward, Heather A., Wark, Petra A., Muller, David C., Steffen, Annika, Johansson, Mattias, Norat, Teresa, Gunter, Marc J., Overvad, Kim, Dahm, Christina C., Halkjær, Jytte, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Mesrine, Sylvie, Brennan, Paul, Freisling, Heinz, Li, Kuanrong, Kaaks, Rudolf, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salavatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Palli, Domenico, Peeters, Petra H.M., Bueno-De-Mesquita, H. Bas, Weiderpass, Elisabete, Agudo, Antonio, Quiros, Jose Ramon, Larranaga, Nerea, Ardanaz, Eva, Huerta, Jose María, Sanchez, María Jose, Laurell, Goran, Johansson, Ingegerd, Westin, Ulla, Wallstrom, Peter, Bradbury, Kathryn E., Wareham, Nicholas J., Khaw, Kay Tee, Pearson, Clare, Boeing, Heiner, and Riboli, Elio
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- 2017
22. Measured adiposity in relation to head and neck cancer risk in the European prospective investigation into cancer and nutrition
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Epi Kanker Team B, UMC Utrecht, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Ward, Heather A., Wark, Petra A., Muller, David C., Steffen, Annika, Johansson, Mattias, Norat, Teresa, Gunter, Marc J., Overvad, Kim, Dahm, Christina C., Halkjær, Jytte, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Mesrine, Sylvie, Brennan, Paul, Freisling, Heinz, Li, Kuanrong, Kaaks, Rudolf, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salavatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Palli, Domenico, Peeters, Petra H.M., Bueno-De-Mesquita, H. Bas, Weiderpass, Elisabete, Agudo, Antonio, Quiros, Jose Ramon, Larranaga, Nerea, Ardanaz, Eva, Huerta, Jose María, Sanchez, María Jose, Laurell, Goran, Johansson, Ingegerd, Westin, Ulla, Wallstrom, Peter, Bradbury, Kathryn E., Wareham, Nicholas J., Khaw, Kay Tee, Pearson, Clare, Boeing, Heiner, Riboli, Elio, Epi Kanker Team B, UMC Utrecht, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Ward, Heather A., Wark, Petra A., Muller, David C., Steffen, Annika, Johansson, Mattias, Norat, Teresa, Gunter, Marc J., Overvad, Kim, Dahm, Christina C., Halkjær, Jytte, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Mesrine, Sylvie, Brennan, Paul, Freisling, Heinz, Li, Kuanrong, Kaaks, Rudolf, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salavatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Palli, Domenico, Peeters, Petra H.M., Bueno-De-Mesquita, H. Bas, Weiderpass, Elisabete, Agudo, Antonio, Quiros, Jose Ramon, Larranaga, Nerea, Ardanaz, Eva, Huerta, Jose María, Sanchez, María Jose, Laurell, Goran, Johansson, Ingegerd, Westin, Ulla, Wallstrom, Peter, Bradbury, Kathryn E., Wareham, Nicholas J., Khaw, Kay Tee, Pearson, Clare, Boeing, Heiner, and Riboli, Elio
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- 2017
23. Diet quality scores and prediction of all-cause, cardiovascular and cancer mortality in a pan-european cohort study
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Lassale, Camille, Gunter, Marc J., Romaguera, Dora, Peelen, Linda M., Van der Schouw, Yvonne T., Beulens, Joline W. J., Freisling, Heinz, Muller, David C., Ferrari, Pietro, Huybrechts, Inge, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Affret, Aurelie, Overvad, Kim, Dahm, Christina C., Olsen, Anja, Roswall, Nina, Tsilidis, Konstantinos K., Katzke, Verena A., Kuehn, Tilman, Buijsse, Brian, Quiros, Jose-Ramon, Sanchez-Cantalejo, Emilio, Etxezarreta, Nerea, Maria Huerta, Jose, Barricarte, Aurelio, Bonet, Catalina, Khaw, Kay-Tee, Key, Timothy J., Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Fasanelli, Francesca, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Boer, Jolanda M. A., Sonestedt, Emily, Nilsson, Lena Maria, Renstrom, Frida, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Moons, Karel G. M., Riboli, Elio, Tzoulaki, Ioanna, Khaw, Kay-Tee [0000-0002-8802-2903], Apollo - University of Cambridge Repository, Epidemiology and Data Science, EMGO - Lifestyle, overweight and diabetes, Lassale, Camille, Gunter, Marc J, Romaguera, Dora, Peelen, Linda M, Van der Schouw, Yvonne T, Beulens, Joline W. J, Freisling, Heinz, Muller, David C, Ferrari, Pietro, Huybrechts, Inge, Fagherazzi, Guy, Boutron Ruault, Marie Christine, Affret, Aurélie, Overvad, Kim, Dahm, Christina C, Olsen, Anja, Roswall, Nina, Tsilidis, Konstantinos K, Katzke, Verena A, Kühn, Tilman, Buijsse, Brian, Quirós, José Ramón, Sánchez Cantalejo, Emilio, Etxezarreta, Nerea, Huerta, José María, Barricarte, Aurelio, Bonet, Catalina, Khaw, Kay Tee, Key, Timothy J, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Fasanelli, Francesca, Panico, Salvatore, Bueno de Mesquita, H. Ba, Boer, Jolanda M. A, Sonestedt, Emily, Nilsson, Lena Maria, Renström, Frida, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Moons, Karel G. M, Riboli, Elio, Tzoulaki, Ioanna, [Lassale,C, Gunter,MJ, Romaguera,D, Tsilidis,KK, Riboli,E, Tzoulaki,I] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom. [Romaguera,D] Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain. [Romaguera,D, Quirós,J, Sánchez-Cantalejo,E, Etxezarreta,N, Huerta,JM, Barricarte,A, Bonet,C] CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. [Peelen,LM, Schouw,ITV, Beulens,JWJ, Moons,KGM] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.[Freisling,H, Muller,DC, Ferrari,P, Huybrechts,I] International Agency for Research on Cancer, Lyon, France. [Fagherazz,G, Boutron-Ruault,M, Affret,A] Institut National de la Santé et de la Recherche Médicale, Center for Research in Epidemiology and Population, Health, Villejuif, France. Institut Gustave Roussy, Villejuif, France. Paris South University, Unité Mixte de Recherche, Villejuif, France. [Overvad,K, Dahm,CC] Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. [Olsen,A, Roswall,N] Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark. [Tsilidis,KK] German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany. [Katzke,VA, Kühn,T] Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke German Institute of Human Nutrition, Potsdam, Germany. [Buijsse,B] Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece. [Quirós,R] Public Health Directorate, Asturias, Oviedo, Spain. [Sánchez-Cantalejo,E] Andalusian School of Public Health, Granada, Spain. [Etxezarreta,N] Public Health Direction and Biodonostia Basque Regional Health Department, San Sebastian, Spain. [Huerta,JM] Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain. [Barricarte,A] Navarre Public Health Institute, Pamplona, Spain. [Bonet,C] Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology, Barcelona, Spain. [Khaw,K] University of Cambridge School of Clinical Medicine, Clinical Gerontology Unit, Cambridge, United Kingdom. [Key,J] Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom. [Trichopoulou,A, Bamia,C, Lagiou,P] Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. Hellenic Health Foundation, Athens, Greece. [Palli,D] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute—ISPO, Florence, Italy. [Agnoli,C] Epidemiology and Prevention Unit, Department of Preventive and Predictive Medicine, Foundation of the Carlo Besta Neurological Institute, Milan, Italy. [Tumino,R] Cancer Registry and Histopathology Unit, 'Civic MP Arezzo' Hospital, Ragusa, Italy. [Fasanelli,F] Human Genetics Foundation, Turin, Italy. [Bueno-de-Mesquita,HB, Boer,JMA] Center for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, Netherlands. [Sonestedt,E] Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. [Nilsson,LM, Renström,F] Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden. [Weiderpass,E, Skeie,G, Lund,E] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. [Weiderpass,E] Department of Research, Cancer Registry of Norway, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland., Funding: The coordination of EPIC is financially supported by the European Commission (DGSANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France), German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany), the Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands), Health Research Fund (FIS), PI13/00061 to Granada, Regional Governments of Andalucía, Asturias, Basque Country, Murcia (no. 6236) and Navarra, ISCIII RETIC (RD06/0020) (Spain), Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden), Cancer Research UK (14136 to EPIC-Norfolk, and C570/ A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/ M012190/1 to EPIC-Oxford) (United Kingdom).
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Male ,humanos ,Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings] ,Social Sciences ,Índice de masa corporal ,Global Health ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings] ,Cohort Studies ,distribución por sexos ,Mathematical and Statistical Techniques ,Sociology ,Risk Factors ,Neoplasms ,Medicine and Health Sciences ,Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity [Medical Subject Headings] ,Public and Occupational Health ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional Status [Medical Subject Headings] ,Estado Nutricional ,estudios de cohortes ,mediana edad ,Factores de Riesgo ,neoplasias ,Medicine(all) ,Nutrition and Dietetics ,VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801 ,Agricultural and Biological Sciences(all) ,dieta ,Agriculture ,Public Health, Global Health, Social Medicine and Epidemiology ,Estudios Prospectivos ,Plants ,Diseases::Neoplasms [Medical Subject Headings] ,Middle Aged ,Neoplasias ,Näringslära ,Cardiovascular Diseases ,Hábitos alimenticios ,estilo de vida ,Physical Sciences ,Medicine ,Dieta ,Female ,Statistics (Mathematics) ,Research Article ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings] ,General Science & Technology ,Science ,Estudios de cohortes ,European Continental Ancestry Group ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Smoking [Medical Subject Headings] ,enfermedades cardiovasculares ,Crops ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings] ,Research and Analysis Methods ,White People ,Education ,Fruits ,Age Distribution ,distribución por edades ,SDG 3 - Good Health and Well-being ,MD Multidisciplinary ,Anatomy::Cardiovascular System [Medical Subject Headings] ,Journal Article ,factores de riesgo ,Humans ,Statistical Methods ,Sex Distribution ,Life Style ,Educational Attainment ,Nutrition ,Sistema cardiovascular ,Biochemistry, Genetics and Molecular Biology(all) ,Organisms ,Biology and Life Sciences ,Physical Activity ,Nutrients ,Actividad motora ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior::Food Habits [Medical Subject Headings] ,Diet ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings] ,Hábito de Fumar ,VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 ,grupo de ascendencia continental europea ,Mathematics ,Forecasting ,Crop Science - Abstract
Scores of overall diet quality have received increasing attention in relation to disease aetiology; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective Investigation into Cancer and Nutrition, followed-up for a median of 12.8y. All dietary scores studied showed significant inverse associations with all outcomes. The range of HRs (95% CI) in the top vs. lowest quartile of dietary scores in a composite model including non-invasive factors (age, sex, smoking, body mass index, education, physical activity and study centre) was 0.75 (0.72-0.79) to 0.88 (0.84-0.92) for all-cause, 0.76 (0.69-0.83) to 0.84 (0.76-0.92) for CVD and 0.78 (0.73-0.83) to 0.91 (0.85-0.97) for cancer mortality. Models with dietary scores alone showed low discrimination, but composite models also including age, sex and other non-invasive factors showed good discrimination and calibration, which varied little between different diet scores examined. Mean C-statistic of full models was 0.73, 0.80 and 0.71 for all-cause, CVD and cancer mortality. Dietary scores have poor predictive performance for 10-year mortality risk when used in isolation but display good predictive ability in combination with other non-invasive common risk factors., The coordination of EPIC is financially supported by the European Commission (D-GSANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC- Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS), PI13/00061 to Granada, Regional Governments of Andalucia, Asturias, Basque Country, Murcia (no. 6236) and Navarra, ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skane and Vasterbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom).
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- 2016
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24. Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort
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Molina-Montes, Esther Sanchez, Maria-Jose Zamora-Ros, Raul and Bueno-de-Mesquita, H. B(as) Wark, Petra A. Obon-Santacana, Mireia Kuehn, Tilman Katzke, Verena Travis, Ruth C. Ye, Weimin Sund, Malin Naccarati, Alessio Mattiello, Amalia and Krogh, Vittorio Martorana, Caterina Masala, Giovanna Amiano, Pilar Huerta, Jose-Maria Barricarte, Aurelio Quiros, Jose-Ramon Weiderpass, Elisabete Asli, Lene Angell Skeie, Guri Ericson, Ulrika Sonestedt, Emily Peeters, Petra H. and Romieu, Isabelle Scalbert, Augustin Overvad, Kim Clemens, Matthias Boeing, Heiner Trichopoulou, Antonia Peppa, Eleni and Vidalis, Pavlos Khaw, Kay-Tee Wareham, Nick Olsen, Anja and Tjonneland, Anne Boutroun-Rualt, Marie-Christine and Clavel-Chapelon, Francoise Cross, Amanda J. Lu, Yunxia and Riboli, Elio Duell, Eric J.
- Abstract
Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake=1.03, 95% CI: 0.95-1.11 and 1.02; 95% CI: 0.89-1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake=0.96, 95% CI: 0.91-1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort. What’s new? Flavonoids and lignans found in plant-based foods are potent cancer chemopreventive agents but little is known about their effects on pancreatic cancer risk. Here the authors address this question in a large prospective epidemiological study using comprehensively derived dietary data. Their results support growing evidence that there is no association between food-based consumption of both substances with pancreatic cancer risk.
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- 2016
25. Diet Quality Scores and Prediction of All-Cause, Cardiovascular and Cancer Mortality in a Pan-European Cohort Study
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Lassale, Camille Gunter, Marc J. Romaguera, Dora Peelen, Linda M. Van der Schouw, Yvonne T. Beulens, Joline W. J. and Freisling, Heinz Muller, David C. Ferrari, Pietro and Huybrechts, Inge Fagherazzi, Guy Boutron-Ruault, Marie-Christine and Affret, Aurelie Overvad, Kim Dahm, Christina C. Olsen, Anja Roswall, Nina Tsilidis, Konstantinos K. Katzke, Verena A. Kuehn, Tilman Buijsse, Brian Quiros, Jose-Ramon and Sanchez-Cantalejo, Emilio Etxezarreta, Nerea Maria Huerta, Jose and Barricarte, Aurelio Bonet, Catalina Khaw, Kay-Tee Key, Timothy J. Trichopoulou, Antonia Bamia, Christina Lagiou, Pagona Palli, Domenico Agnoli, Claudia Tumino, Rosario and Fasanelli, Francesca Panico, Salvatore Bueno-de-Mesquita, H. Bas and Boer, Jolanda M. A. Sonestedt, Emily Nilsson, Lena Maria and Renstrom, Frida Weiderpass, Elisabete Skeie, Guri Lund, Eiliv Moons, Karel G. M. Riboli, Elio Tzoulaki, Ioanna
- Abstract
Scores of overall diet quality have received increasing attention in relation to disease aetiology; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective Investigation into Cancer and Nutrition, followed-up for a median of 12.8y. All dietary scores studied showed significant inverse associations with all outcomes. The range of HRs (95% CI) in the top vs. lowest quartile of dietary scores in a composite model including non-invasive factors (age, sex, smoking, body mass index, education, physical activity and study centre) was 0.75 (0.72-0.79) to 0.88 (0.84-0.92) for all-cause, 0.76 (0.69-0.83) to 0.84 (0.76-0.92) for CVD and 0.78 (0.73-0.83) to 0.91 (0.85-0.97) for cancer mortality. Models with dietary scores alone showed low discrimination, but composite models also including age, sex and other non-invasive factors showed good discrimination and calibration, which varied little between different diet scores examined. Mean C-statistic of full models was 0.73, 0.80 and 0.71 for all-cause, CVD and cancer mortality. Dietary scores have poor predictive performance for 10-year mortality risk when used in isolation but display good predictive ability in combination with other non-invasive common risk factors.
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- 2016
26. Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study
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Ambatipudi, Srikant Cuenin, Cyrille Hernandez-Vargas, Hector and Ghantous, Akram Le Calvez-Kelm, Florence Kaaks, Rudolf and Barrdahl, Myrto Boeing, Heiner Aleksandrova, Krasimira and Trichopoulou, Antonia Lagiou, Pagona Naska, Androniki Palli, Domenico Krogh, Vittorio Polidoro, Silvia Tumino, Rosario and Panico, Salvatore Bueno-de-Mesquita, Bas Peeters, Petra H. M. Quiros, Jose Ramon Navarro, Carmen Ardanaz, Eva and Dorronsoro, Miren Key, Tim Vineis, Paolo Murphy, Neil and Riboli, Elio Romieu, Isabelle Herceg, Zdenko
- Abstract
Aim: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. Materials & methods: Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in a large multinational cohort. Results: We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation. Conclusion: Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.
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- 2016
27. Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer
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Nimptsch, Katharina Aleksandrova, Krasimira Boeing, Heiner and Janke, Juergen Lee, Young-Ae Jenab, Mazda Kong, So Yeon and Tsilidis, Konstantinos K. Weiderpass, Elisabete and Bueno-de-Mesquita, H. B(As) Siersema, Peter D. Jansen, Eugene H. J. M. Trichopoulou, Antonia Tjonneland, Anne Olsen, Anja and Wu, Chunsen Overvad, Kim Boutron-Ruault, Marie-Christine and Racine, Antoine Freisling, Heinz Katzke, Verena Kaaks, Rudolf Lagiou, Pagona Trichopoulos, Dimitrios Severi, Gianluca Naccarati, Alessio Mattiello, Amalia Palli, Domenico Grioni, Sara Tumino, Rosario Peeters, Petra H. and Ljuslinder, Ingrid Nystrom, Hanna Brandstedt, Jenny Sanchez, Maria-Jose Gurrea, Aurelio Barricarte Bonet, Catalina Bonet and Chirlaque, Maria-Dolores Dorronsoro, Miren Quiros, Jose Ramon and Travis, Ruth C. Khaw, Kay-Tee Wareham, Nick Riboli, Elio and Gunter, Marc J. Pischon, Tobias
- Abstract
Fetuin-A, also referred to as alpha 2-Heremans-Schmid glycoprotein (AHSG), is a liver protein known to inhibit insulin actions. Hyperinsulinemia is a possible risk factor for colorectal cancer; however, the role of fetuin-A in the development of colorectal cancer is unclear. We investigated the association between circulating fetuin-A and colorectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. Fetuin-A concentrations were measured in prediagnostic plasma samples from 1,367 colorectal cancer cases and 1,367 matched controls. In conditional logistic regression models adjusted for potential confounders, the estimated relative risk (95% confidence interval) of colorectal cancer per 40 mg/mL higher fetuin-A concentrations (approximately one standard deviation) was 1.13 (1.02-1.24) overall, 1.21 (1.05-1.39) in men, 1.06 (0.93-1.22) in women, 1.13 (1.00-1.27) for colon cancer and 1.12 (0.94-1.32) for rectal cancer. To improve causal inference in a Mendelian Randomization approach, five tagging single nucleotide polymorphisms of the AHSG gene were genotyped in a subset of 456 case-control pairs. The AHSG allele-score explained 21% of the interindividual variation in plasma fetuin-A concentrations. In instrumental variable analysis, genetically raised fetuin-A was not associated with colorectal cancer risk (relative risk per 40 mg/mL genetically determined higher fetuin-A was 0.98, 95% confidence interval: 0.73-1.33). The findings of our study indicate a modest linear association between fetuin-A concentrations and risk of colorectal cancer but suggest that fetuin-A may not be causally related to colorectal cancer development.
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- 2015
28. Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes A Meta-analysis
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Lotta, Luca A., Sharp, Stephen J., Burgess, Stephen, Perry, John R. B., Stewart, Isobel D., Willems, Sara M., Luan, Jian'an, Ardanaz, Eva, Arriola, Larraitz, Balkau, Beverley, Boeing, Heiner, Deloukas, Panos, Forouhi, Nita G., Franks, Paul W., Grioni, Sara, Kaaks, Rudolf, Key, Timothy J., Navarro, Carmen, Nilsson, Peter M., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quiros, Jose-Ramon, Riboli, Elio, Rolandsson, Olov, Sacerdote, Carlotta, Salamanca-Fernandez, Elena, Slimani, Nadia, Spijkerman, Annemieke M. W., Tjonneland, Anne, Tumino, Rosario, van der A, Daphne L., van der Schouw, Yvonne T., McCarthy, Mark I., Barroso, Ines, O'Rahilly, Stephen, Savage, David B., Sattar, Naveed, Langenberg, Claudia, Scott, Robert A., Wareham, Nicholas J., Lotta, Luca A., Sharp, Stephen J., Burgess, Stephen, Perry, John R. B., Stewart, Isobel D., Willems, Sara M., Luan, Jian'an, Ardanaz, Eva, Arriola, Larraitz, Balkau, Beverley, Boeing, Heiner, Deloukas, Panos, Forouhi, Nita G., Franks, Paul W., Grioni, Sara, Kaaks, Rudolf, Key, Timothy J., Navarro, Carmen, Nilsson, Peter M., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quiros, Jose-Ramon, Riboli, Elio, Rolandsson, Olov, Sacerdote, Carlotta, Salamanca-Fernandez, Elena, Slimani, Nadia, Spijkerman, Annemieke M. W., Tjonneland, Anne, Tumino, Rosario, van der A, Daphne L., van der Schouw, Yvonne T., McCarthy, Mark I., Barroso, Ines, O'Rahilly, Stephen, Savage, David B., Sattar, Naveed, Langenberg, Claudia, Scott, Robert A., and Wareham, Nicholas J.
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Importance Low-density lipoprotein cholesterol (LDL-C)–lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a higher risk of type 2 diabetes, similar to the increased incidence of new-onset diabetes associated with statin treatment in randomized clinical trials. It is unknown whether alleles near NPC1L1 are associated with the risk of type 2 diabetes. Objective To investigate whether LDL-C-lowering alleles in or near NPC1L1 and other genes encoding current or prospective molecular targets of lipid-lowering therapy (ie, HMGCR, PCSK9, ABCG5/G8, LDLR) are associated with the risk of type 2 diabetes. Design, Setting, and Participants The associations with type 2 diabetes and coronary artery disease of LDL-C-lowering genetic variants were investigated in meta-analyses of genetic association studies. Meta-analyses included 50 775 individuals with type 2 diabetes and 270 269 controls and 60 801 individuals with coronary artery disease and 123 504 controls. Data collection took place in Europe and the United States between 1991 and 2016. Exposures Low-density lipoprotein cholesterol–lowering alleles in or near NPC1L1, HMGCR, PCSK9, ABCG5/G8, and LDLR. Main Outcomes and Measures Odds ratios (ORs) for type 2 diabetes and coronary artery disease. Results Low-density lipoprotein cholesterol–lowering genetic variants at NPC1L1 were inversely associated with coronary artery disease (OR for a genetically predicted 1-mmol/L [38.7-mg/dL] reduction in LDL-C of 0.61 [95% CI, 0.42-0.88]; P = .008) and directly associated with type 2 diabetes (OR for a genetically predicted 1-mmol/L reduction in LDL-C of 2.42 [95% CI, 1.70-3.43]; P < .001). For PCSK9 genetic variants, the OR for type 2 diabetes per 1-mmol/L genetically predicted reduction in LDL-C was 1.19 (95% CI, 1.02-1.38; P = .03). For a
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- 2016
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29. Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort
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Molina-Montes, Esther, Sanchez, Maria-Jose, Zamora-Ros, Raul, Bueno-de-Mesquita, H. B(as), Wark, Petra A., Obon-Santacana, Mireia, Kuehn, Tilman, Katzke, Verena, Travis, Ruth C., Ye, Weimin, Sund, Malin, Naccarati, Alessio, Mattiello, Amalia, Krogh, Vittorio, Martorana, Caterina, Masala, Giovanna, Amiano, Pilar, Huerta, Jose-Maria, Barricarte, Aurelio, Quiros, Jose-Ramon, Weiderpass, Elisabete, Asli, Lene Angell, Skeie, Guri, Ericson, Ulrika, Sonestedt, Emily, Peeters, Petra H., Romieu, Isabelle, Scalbert, Augustin, Overvad, Kim, Clemens, Matthias, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Vidalis, Pavlos, Khaw, Kay-Tee, Wareham, Nick, Olsen, Anja, Tjonneland, Anne, Boutroun-Rualt, Marie-Christine, Clavel-Chapelon, Francoise, Cross, Amanda J., Lu, Yunxia, Riboli, Elio, Duell, Eric J., Molina-Montes, Esther, Sanchez, Maria-Jose, Zamora-Ros, Raul, Bueno-de-Mesquita, H. B(as), Wark, Petra A., Obon-Santacana, Mireia, Kuehn, Tilman, Katzke, Verena, Travis, Ruth C., Ye, Weimin, Sund, Malin, Naccarati, Alessio, Mattiello, Amalia, Krogh, Vittorio, Martorana, Caterina, Masala, Giovanna, Amiano, Pilar, Huerta, Jose-Maria, Barricarte, Aurelio, Quiros, Jose-Ramon, Weiderpass, Elisabete, Asli, Lene Angell, Skeie, Guri, Ericson, Ulrika, Sonestedt, Emily, Peeters, Petra H., Romieu, Isabelle, Scalbert, Augustin, Overvad, Kim, Clemens, Matthias, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Vidalis, Pavlos, Khaw, Kay-Tee, Wareham, Nick, Olsen, Anja, Tjonneland, Anne, Boutroun-Rualt, Marie-Christine, Clavel-Chapelon, Francoise, Cross, Amanda J., Lu, Yunxia, Riboli, Elio, and Duell, Eric J.
- Abstract
Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake=1.03, 95% CI: 0.95-1.11 and 1.02; 95% CI: 0.89-1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake=0.96, 95% CI: 0.91-1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort. What's new? Flavonoids and lignans found in plant-based foods are potent cancer chemopreventive agents but little is known about their effects on pancreatic cancer risk. Here the authors address this question in a large prospective epidemiological study using comprehensively derived dietary data. Their results support growing evidence that there is no association between food-based consumption
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- 2016
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30. Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study
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LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, dIRAS RA-2, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A, Ward, Heather A, Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M, Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H, Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria-Dolores, Travier, Noémie, Travis, Ruth C, Sanchez, Maria-Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, Vineis, Paolo, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, dIRAS RA-2, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A, Ward, Heather A, Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M, Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H, Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria-Dolores, Travier, Noémie, Travis, Ruth C, Sanchez, Maria-Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, and Vineis, Paolo
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- 2016
31. Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study
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Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A., Ward, Heather A., Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M., Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H., Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria Dolores, Travier, Noémie, Travis, Ruth C., Sanchez, Maria Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, Vineis, Paolo, Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Gallo, Valentina, Vanacore, Nicola, Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Brayne, Carol, Pearce, Neil, Wark, Petra A., Ward, Heather A., Ferrari, Pietro, Jenab, Mazda, Andersen, Peter M., Wennberg, Patrik, Wareham, Nicholas, Katzke, Verena, Kaaks, Rudolf, Weiderpass, Elisabete, Peeters, Petra H., Mattiello, Amalia, Pala, Valeria, Barricante, Aurelio, Chirlaque, Maria Dolores, Travier, Noémie, Travis, Ruth C., Sanchez, Maria Jose, Pessah-Rasmussen, Hélène, Petersson, Jesper, Tjønneland, Anne, Tumino, Rosario, Quiros, Jose Ramon, Trichopoulou, Antonia, Kyrozis, Andreas, Oikonomidou, Despoina, Masala, Giovanna, Sacerdote, Carlotta, Arriola, Larraitz, Boeing, Heiner, Vigl, Matthaeus, Claver-Chapelon, Francoise, Middleton, Lefkos, Riboli, Elio, and Vineis, Paolo
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- 2016
32. Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study
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Aleksandrova, Krasimira Pischon, Tobias Jenab, Mazda and Bueno-de-Mesquita, H. Bas Fedirko, Veronika Norat, Teresa and Romaguera, Dora Knueppel, Sven Boutron-Ruault, Marie-Christine and Dossus, Laure Dartois, Laureen Kaaks, Rudolf Li, Kuanrong Tjonneland, Anne Overvad, Kim Quiros, Jose Ramon and Buckland, Genevieve Sanchez, Maria Jose Dorronsoro, Miren and Chirlaque, Maria-Dolores Barricarte, Aurelio Khaw, Kay-Tee and Wareham, Nicholas J. Bradbury, Kathryn E. Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico Krogh, Vittorio Tumino, Rosario Naccarati, Alessio and Panico, Salvatore Siersema, Peter D. Peeters, Petra H. M. and Ljuslinder, Ingrid Johansson, Ingegerd Ericson, Ulrika and Ohlsson, Bodil Weiderpass, Elisabete Skeie, Guri Borch, Kristin Benjaminsen Rinaldi, Sabina Romieu, Isabelle Kong, Joyce Gunter, Marc J. Ward, Heather A. Riboli, Elio and Boeing, Heiner
- Abstract
Background: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors healthy weight, physical activity, non-smoking, limited alcohol consumption and a healthy diet, and to explore the association of this index with CRC incidence using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: In the EPIC cohort, a total of 347,237 men and women, 25- to 70-years old, provided dietary and lifestyle information at study baseline (1992 to 2000). Over a median follow-up time of 12 years, 3,759 incident CRC cases were identified. The association between a HLI and CRC risk was evaluated using Cox proportional hazards regression models and population attributable risks (PARs) have been calculated. Results: After accounting for study centre, age, sex and education, compared with 0 or 1 healthy lifestyle factors, the hazard ratio (HR) for CRC was 0.87 (95% confidence interval (CI): 0.44 to 0.77) for two factors, 0.79 (95% CI: 0.70 to 0.89) for three factors, 0.66 (95% CI: 0.58 to 0.75) for four factors and 0.63 (95% CI: 0.54 to 0.74) for five factors; P-trend
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- 2014
33. Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: Etiological factors or risk markers?
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Lukanova, Annekatrin Becker, Susen Huesing, Anika Schock, Helena Fedirko, Veronika Trepo, Elisabeth Trichopoulou, Antonia Bamia, Christina Lagiou, Pagona Benetou, Vassiliki and Trichopoulos, Dimitrios Noethlings, Ute Tjonneland, Anne and Overvad, Kim Dossus, Laure Teucher, Birgit Boeing, Heiner and Aleksandrova, Krasimira Palli, Domenico Pala, Valeria and Panico, Salvatore Tumino, Rosario Ricceri, Fulvio and Bueno-De-Mesquita, H. Bas Siersema, Peter D. Peeters, Petra H. M. Quiros, Jose Ramon Duell, Eric J. Molina-Montes, Esther and Chirlaque, Maria-Dolores Gurrea, Aurelio Barricarte and Dorronsoro, Miren Lindkvist, Bjoern Johansen, Dorthe Werner, Marten Sund, Malin Khaw, Kay-Tee Wareham, Nick Key, Timothy J. Travis, Ruth C. Rinaldi, Sabina Romieu, Isabelle and Gunter, Marc J. Riboli, Elio Jenab, Mazda Kaaks, Rudolf
- Abstract
Elevated prediagnostic testosterone and insulin-like growth factor I (IGF-I) concentrations have been proposed to increase risk of hepatocellular carcinoma (HCC). However, the metabolism of these hormones is altered as a consequence of liver damage and they may have clinical utility as HCC risk markers. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition cohort and included 125 incident HCC cases and 247 individually matched controls. Testosterone, sex hormone-binding globulin (SHBG) and IGF-I were analyzed by immunoassays. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by conditional logistic regression. The area under the receiver operating curves (AUC) was calculated to assess HCC predictive ability of the tested models. After adjustments for epidemiological variables (body mass index, smoking, ethanol intake, hepatitis and diabetes) and liver damage (a score based on albumin, bilirubin, aspartate aminotransaminase, alanine aminotransaminase, gamma-glutamyltransferase and alkaline phosphatase concentrations), only SHBG remained significantly associated with risk [OR for top versus bottom tertile of 3.86 (1.32-11.3), p(trend) = 0.009]. As a single factor SHBG had an AUC of 0.81 (0.75-0.86). A small, but significant increase in AUC was observed when SHBG was added to a model including the liver damage score and epidemiological variables (from 0.89 to 0.91, p = 0.02) and a net reclassification of 0.47% (0.45-0.48). The observed associations of HCC with prediagnostic SHBG, free testosterone and IGF-I concentrations are in directions opposite to that expected under the etiological hypotheses. SHBG has a potential to be tested as prediagnostic risk marker for HCC. (c) 2013 UICC What’s new? Testosterone and insulin-like growth factor-1 (IGF-1) are implicated in the development of hepatocellular carcinoma (HCC), though their involvement may be more complex than previously thought. Here, in a unique study population with low prevalence of hepatitis infections, an association was detected between HCC risk and increased levels of sex hormone binding globulin (SHBG) and IGF-1 prior to diagnosis. Neither testosterone nor IGF-1, however, was found to have an etiological influence in the decade before diagnosis. The results suggest that SHBG and IGF-I should be considered in the clinical evaluation of patients at increased risk of HCC.
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- 2014
34. Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer
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Nimptsch, Katharina, Aleksandrova, Krasimira, Boeing, Heiner, Janke, Juergen, Lee, Young-Ae, Jenab, Mazda, Kong, So Yeon, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Bueno-de-Mesquita, H. B(As), Siersema, Peter D., Jansen, Eugene H. J. M., Trichopoulou, Antonia, Tjonneland, Anne, Olsen, Anja, Wu, Chunsen, Overvad, Kim, Boutron-Ruault, Marie-Christine, Racine, Antoine, Freisling, Heinz, Katzke, Verena, Kaaks, Rudolf, Lagiou, Pagona, Trichopoulos, Dimitrios, Severi, Gianluca, Naccarati, Alessio, Mattiello, Amalia, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Peeters, Petra H., Ljuslinder, Ingrid, Nyström, Hanna, Brandstedt, Jenny, Sanchez, Maria-Jose, Gurrea, Aurelio Barricarte, Bonet, Catalina Bonet, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Quiros, Jose Ramon, Travis, Ruth C., Khaw, Kay-Tee, Wareham, Nick, Riboli, Elio, Gunter, Marc J., Pischon, Tobias, Nimptsch, Katharina, Aleksandrova, Krasimira, Boeing, Heiner, Janke, Juergen, Lee, Young-Ae, Jenab, Mazda, Kong, So Yeon, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Bueno-de-Mesquita, H. B(As), Siersema, Peter D., Jansen, Eugene H. J. M., Trichopoulou, Antonia, Tjonneland, Anne, Olsen, Anja, Wu, Chunsen, Overvad, Kim, Boutron-Ruault, Marie-Christine, Racine, Antoine, Freisling, Heinz, Katzke, Verena, Kaaks, Rudolf, Lagiou, Pagona, Trichopoulos, Dimitrios, Severi, Gianluca, Naccarati, Alessio, Mattiello, Amalia, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Peeters, Petra H., Ljuslinder, Ingrid, Nyström, Hanna, Brandstedt, Jenny, Sanchez, Maria-Jose, Gurrea, Aurelio Barricarte, Bonet, Catalina Bonet, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Quiros, Jose Ramon, Travis, Ruth C., Khaw, Kay-Tee, Wareham, Nick, Riboli, Elio, Gunter, Marc J., and Pischon, Tobias
- Abstract
Fetuin-A, also referred to as alpha 2-Heremans-Schmid glycoprotein (AHSG), is a liver protein known to inhibit insulin actions. Hyperinsulinemia is a possible risk factor for colorectal cancer; however, the role of fetuin-A in the development of colorectal cancer is unclear. We investigated the association between circulating fetuin-A and colorectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. Fetuin-A concentrations were measured in prediagnostic plasma samples from 1,367 colorectal cancer cases and 1,367 matched controls. In conditional logistic regression models adjusted for potential confounders, the estimated relative risk (95% confidence interval) of colorectal cancer per 40 mg/mL higher fetuin-A concentrations (approximately one standard deviation) was 1.13 (1.02-1.24) overall, 1.21 (1.05-1.39) in men, 1.06 (0.93-1.22) in women, 1.13 (1.00-1.27) for colon cancer and 1.12 (0.94-1.32) for rectal cancer. To improve causal inference in a Mendelian Randomization approach, five tagging single nucleotide polymorphisms of the AHSG gene were genotyped in a subset of 456 case-control pairs. The AHSG allele-score explained 21% of the interindividual variation in plasma fetuin-A concentrations. In instrumental variable analysis, genetically raised fetuin-A was not associated with colorectal cancer risk (relative risk per 40 mg/mL genetically determined higher fetuin-A was 0.98, 95% confidence interval: 0.73-1.33). The findings of our study indicate a modest linear association between fetuin-A concentrations and risk of colorectal cancer but suggest that fetuin-A may not be causally related to colorectal cancer development.
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- 2015
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35. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
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Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Meplan, Catherine, Freisling, Heinz, Bueno-de-Mesquita, H. B(as), Hybsier, Sandra, Becker, Niels-Peter, Czuban, Magdalena, Tjonneland, Anne, Outzen, Malene, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadia, Kuehn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria-Dolores, Sanchez, Maria-Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E., Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quiros, Jose Ramon, Stepien, Magdalena, Kong, So Yeon, Duarte-Salles, Talita, Riboli, Elio, Hesketh, John E., Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Meplan, Catherine, Freisling, Heinz, Bueno-de-Mesquita, H. B(as), Hybsier, Sandra, Becker, Niels-Peter, Czuban, Magdalena, Tjonneland, Anne, Outzen, Malene, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadia, Kuehn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria-Dolores, Sanchez, Maria-Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E., Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quiros, Jose Ramon, Stepien, Magdalena, Kong, So Yeon, Duarte-Salles, Talita, Riboli, Elio, and Hesketh, John E.
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- 2015
36. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
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Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Meplan, Catherine, Freisling, Heinz, Bueno-de-Mesquita, H. B(as), Hybsier, Sandra, Becker, Niels-Peter, Czuban, Magdalena, Tjonneland, Anne, Outzen, Malene, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadia, Kuehn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria-Dolores, Sanchez, Maria-Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E., Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quiros, Jose Ramon, Stepien, Magdalena, Kong, So Yeon, Duarte-Salles, Talita, Riboli, Elio, Hesketh, John E., Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Meplan, Catherine, Freisling, Heinz, Bueno-de-Mesquita, H. B(as), Hybsier, Sandra, Becker, Niels-Peter, Czuban, Magdalena, Tjonneland, Anne, Outzen, Malene, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadia, Kuehn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria-Dolores, Sanchez, Maria-Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E., Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quiros, Jose Ramon, Stepien, Magdalena, Kong, So Yeon, Duarte-Salles, Talita, Riboli, Elio, and Hesketh, John E.
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- 2015
37. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition
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Ros, Martine M. Bueno-de-Mesquita, H. Bas Kampman, Ellen and Aben, Katja K. H. Buechner, Frederike L. Jansen, Eugene H. J. M. and van Gils, Carla H. Egevad, Lars Overvad, Kim Tjonneland, Anne Roswall, Nina Boutron-Ruault, Marie Christine Kvaskoff, Marina Perquier, Florence Kaaks, Rudolf Chang-Claude, Jenny and Weikert, Steffen Boeing, Heiner Trichopoulou, Antonia and Lagiou, Pagona Dilis, Vardis Palli, Domenico Pala, Valeria and Sacerdote, Carlotta Tumino, Rosario Panico, Salvatore and Peeters, Petra H. M. Gram, Inger T. Skeie, Guri Huerta, Jose Maria Barricarte, Aurelio Quiros, Jose Ramon Sanchez, Maria Jose Buckland, Genevieve Larranaga, Nerea Ehrnstroem, Roy and Wallstroem, Peter Jungberg, Boerje L. Hallmans, Goeran and Key, Timothy J. Allen, Naomi E. Khaw, Kay-Tee Wareham, Nick and Brennan, Paul Riboli, Elio Kiemeney, Lambertus A.
- Abstract
Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. Results: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma beta-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC. Conclusions: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC. Am J Clin Nutr 2012;96:902-10.
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- 2012
38. Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort
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Molina-Montes, Esther Wark, Petra A. Sanchez, Maria-Jose and Norat, Teresa Jakszyn, Paula Lujan-Barroso, Leila Michaud, Dominique S. Crowe, Francesca Allen, Naomi Khaw, Kay-Tee and Wareham, Nicholas Trichopoulou, Antonia Adarakis, George and Katarachia, Helen Skeie, Guri Henningsen, Maria Broderstad, Ann Ragnhild Berrino, Franco Tumino, Rosario Palli, Domenico and Mattiello, Amalia Vineis, Paolo Amiano, Pilar and Barricarte, Aurelio Huerta, Jose-Maria Duell, Eric J. and Quiros, Jose-Ramon Ye, Weimin Sund, Malin Lindkvist, Bjorn and Johansen, Dorthe Overvad, Kim Tjonneland, Anne Roswall, Nina Li, Kuanrong Grote, Verena A. Steffen, Annika and Boeing, Heiner Racine, Antoine Boutron-Ruault, Marie-Christine and Carbonnel, Franck Peeters, Petra H. M. Siersema, Peter D. and Fedirko, Veronika Jenab, Mazda Riboli, Elio and Bueno-de-Mesquita, Bas
- Abstract
Several studies support a protective effect of dietary magnesium against type 2 diabetes, but a harmful effect for iron. As diabetes has been linked to pancreatic cancer, intake of these nutrients may be also associated with this cancer. We examined the association between dietary intake of magnesium, total iron and heme-iron and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In total, 142,203 men and 334,999 women, recruited between 1992 and 2000, were included. After an average follow-up of 11.3 years, 396 men and 469 women developed exocrine pancreatic cancer. Hazard ratios and 95% confidence intervals (CIs) were obtained using Cox regression stratified by age and center, and adjusted for energy intake, smoking status, height, weight, and self-reported diabetes status. Neither intake of magnesium, total iron nor heme-iron was associated with pancreatic cancer risk. In stratified analyses, a borderline inverse association was observed among overweight men (body mass index, =25 kg/m2) with magnesium (HRper 100 mg/day increase = 0.79, 95% CI = 0.631.01) although this was less apparent using calibrated intake. In female smokers, a higher intake of heme-iron was associated with a higher pancreatic cancer risk (HR per 1 mg/day increase = 1.38, 95% CI = 1.101.74). After calibration, this risk increased significantly to 2.5-fold (95% CI = 1.225.28). Overall, dietary magnesium, total iron and heme-iron were not associated with pancreatic cancer risk during the follow-up period. Our observation that heme-iron was associated with increased pancreatic cancer risk in female smokers warrants replication in additional study populations.
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- 2012
39. Pre-diagnostic plasma testosterone, sex hormone binding globulin, IGF-I and hepatocellular carcinoma : etiological factors or risk markers?
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Lukanova, Annekatrin, Becker, Susen, Hüsing, Anika, Schock, Helena, Fedirko, Veronika, Trepo, Elisabeth, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Benetou, Vassiliki, Trichopoulos, Dimitrios, Nöthlings, Ute, Tjønneland, Anne, Overvad, Kim, Dossus, Laure, Teucher, Birgit, Boeing, Heiner, Aleksandrova, Krasimira, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, H Bas, Siersema, Peter D, Peeters, Petra M, Quiros, Jose Ramon, Duell, Eric J, Molina-Montes, Esther, Chirlaque, Maria-Dolores, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Lindkvist, Björn, Johansen, Dorthe, Werner, Mårten, Sund, Malin, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J, Travis, Ruth C, Rinaldi, Sabina, Romieu, Isabelle, Gunter, Marc J, Riboli, Elio, Jenab, Mazda, Kaaks, Rudolf, Lukanova, Annekatrin, Becker, Susen, Hüsing, Anika, Schock, Helena, Fedirko, Veronika, Trepo, Elisabeth, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Benetou, Vassiliki, Trichopoulos, Dimitrios, Nöthlings, Ute, Tjønneland, Anne, Overvad, Kim, Dossus, Laure, Teucher, Birgit, Boeing, Heiner, Aleksandrova, Krasimira, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, H Bas, Siersema, Peter D, Peeters, Petra M, Quiros, Jose Ramon, Duell, Eric J, Molina-Montes, Esther, Chirlaque, Maria-Dolores, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Lindkvist, Björn, Johansen, Dorthe, Werner, Mårten, Sund, Malin, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J, Travis, Ruth C, Rinaldi, Sabina, Romieu, Isabelle, Gunter, Marc J, Riboli, Elio, Jenab, Mazda, and Kaaks, Rudolf
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Elevated pre-diagnostic testosterone and insulin-like growth factor-I (IGF-I) concentrations have been proposed to increase risk of hepatocellular carcinoma (HCC). However, the metabolism of these hormones is altered as a consequence of liver damage and they may have clinical utility as HCC risk markers. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort and included 125 incident HCC cases and 247 individually matched controls. Testosterone, sex hormone binding globulin (SHBG) and IGF-I were analyzed by immunoassays. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by conditional logistic regression. The area under the receiver operating curves (AUC) was calculated to assess HCC predictive ability of the tested models. After adjustments for epidemiological variables (body mass index, smoking, ethanol intake, hepatitis and diabetes) and liver damage (a score based on albumin, bilirubin, aspartate aminotransaminase, alanine aminotransaminase, gamma-glutamyltransferase and alkaline phosphatase concentrations), only SHBG remained significantly associated with risk (OR for top versus bottom tertile of 3.86 (1.32-11.3), ptrend =0.009). As a single factor SHBG had an AUC of 0.81 (0.75-0.86). A small, but significant increase in AUC was observed when SHBG was added to a model including the liver damage score and epidemiological variables (from 0.89 to 0.91, p=0.02) and a net reclassification of 0.47% (0.45-0.48). The observed associations of HCC with pre-diagnostic SHBG, free testosterone and IGF-I concentrations are in directions opposite to that expected under the etiological hypotheses. SHBG has a potential to be tested as pre-diagnostic risk marker for HCC.
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- 2014
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40. Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study
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Aleksandrova, Krasimira, Pischon, Tobias, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Fedirko, Veronika, Norat, Teresa, Romaguera, Dora, Knueppel, Sven, Boutron-Ruault, Marie-Christine, Dossus, Laure, Dartois, Laureen, Kaaks, Rudolf, Li, Kuanrong, Tjonneland, Anne, Overvad, Kim, Quiros, Jose Ramon, Buckland, Genevieve, Sanchez, Maria Jose, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas J., Bradbury, Kathryn E., Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Siersema, Peter D., Peeters, Petra H. M., Ljuslinder, Ingrid, Johansson, Ingegerd, Ericson, Ulrika, Ohlsson, Bodil, Weiderpass, Elisabete, Skeie, Guri, Borch, Kristin Benjaminsen, Rinaldi, Sabina, Romieu, Isabelle, Kong, Joyce, Gunter, Marc J., Ward, Heather A., Riboli, Elio, Boeing, Heiner, Aleksandrova, Krasimira, Pischon, Tobias, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Fedirko, Veronika, Norat, Teresa, Romaguera, Dora, Knueppel, Sven, Boutron-Ruault, Marie-Christine, Dossus, Laure, Dartois, Laureen, Kaaks, Rudolf, Li, Kuanrong, Tjonneland, Anne, Overvad, Kim, Quiros, Jose Ramon, Buckland, Genevieve, Sanchez, Maria Jose, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nicholas J., Bradbury, Kathryn E., Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Siersema, Peter D., Peeters, Petra H. M., Ljuslinder, Ingrid, Johansson, Ingegerd, Ericson, Ulrika, Ohlsson, Bodil, Weiderpass, Elisabete, Skeie, Guri, Borch, Kristin Benjaminsen, Rinaldi, Sabina, Romieu, Isabelle, Kong, Joyce, Gunter, Marc J., Ward, Heather A., Riboli, Elio, and Boeing, Heiner
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Background: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors healthy weight, physical activity, non-smoking, limited alcohol consumption and a healthy diet, and to explore the association of this index with CRC incidence using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: In the EPIC cohort, a total of 347,237 men and women, 25- to 70-years old, provided dietary and lifestyle information at study baseline (1992 to 2000). Over a median follow-up time of 12 years, 3,759 incident CRC cases were identified. The association between a HLI and CRC risk was evaluated using Cox proportional hazards regression models and population attributable risks (PARs) have been calculated. Results: After accounting for study centre, age, sex and education, compared with 0 or 1 healthy lifestyle factors, the hazard ratio (HR) for CRC was 0.87 (95% confidence interval (CI): 0.44 to 0.77) for two factors, 0.79 (95% CI: 0.70 to 0.89) for three factors, 0.66 (95% CI: 0.58 to 0.75) for four factors and 0.63 (95% CI: 0.54 to 0.74) for five factors; P-trend <0.0001. The associations were present for both colon and rectal cancers, HRs, 0.61 (95% CI: 0.50 to 0.74; P for trend <0.0001) for colon cancer and 0.68 (95% CI: 0.53 to 0.88; P-trend <0.0001) for rectal cancer, respectively (P-difference by cancer sub-site = 0.10). Overall, 16% of the new CRC cases (22% in men and 11% in women) were attributable to not adhering to a combination of all five healthy lifestyle behaviours included in the index. Conclusions: Combined lifestyle factors are associated with a lower incidence of CRC in European populations characterized by western lifestyles. Prevention st
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- 2014
41. A prospective analysis of the association between dietary fiber intake and prostate cancer risk in EPIC
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Suzuki, Reiko Allen, Naomi E. Key, Timothy J. Appleby, Paul N. Tjonneland, Anne Johnsenz, Nina Fons Jensen, Majken K. and Overvad, Kim Boeing, Heiner Pischon, Tobias Kaaks, Rudolf Rohrmann, Sabine Trichopoulou, Antonia Misirli, Gesthimani Trichopoulos, Dimitrios Bueno-de-Mesquita, H. Bas and van Duijnhoven, Franzel Sacerdote, Carlotta Pala, Valeria and Palli, Domenico Tumino, Rosario Ardanaz, Eva Quiros, Jose Ramon Larranaga, Nerea Sanchez, Maria-Jose Tormo, Maria-Jose and Jakszyn, Paula Johansson, Ingegerd Stattin, Par and Berglund, Goran Manjer, Jonas Bingham, Sheila Khaw, Kay-Tee and Egevad, Lars Ferrari, Pietro Jenab, Mazda Riboli, Elio
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Few studies have examined the association between dietary fiber intake and prostate cancer risk. We evaluated the association between dietary fiber intake and the risk of prostate cancer among 142,590 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Consumption of dietary fiber (total, cereal, fruit and vegetable fiber) seas estimated by validated dietary questionnaires and calibrated using 24-hr dietary recalls. Incidence rate ratios were estimated using Cox regression and adjusted for potential confounding factors. During all average of 8.7 years follow-up, prostate cancer was diagnosed in 2,747 men. Overall, there was no association between dietary fiber intake (total, cereal, fruit or vegetable fiber) and prostate cancer risk, although calibrated intakes of total fiber and fruit fiber were associated with nonstatistically significant reductions in risk. There was no association between fiber derived from cereals or vegetables and risk and no evidence for heterogeneity in any of the risk estimates by stage or grade of disease. Our results suggest that dietary fiber intake is not associated with prostate cancer risk. (C) 2008 Wiley-Liss, Inc.
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- 2009
42. Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Dossus, Laure Mckay, James D. Canzian, Federico Wilkening, Stefan Rinaldi, Sabina Biessy, Carine Olsen, Anja and Tjonneland, Anne Jakobsen, Marianne U. Overvad, Kim and Clavel-Chapelon, Francoise Boutron-Ruault, Marie-Christine and Fournier, Agnes Linseisen, Jakob Lukanova, Annekatrin and Boeing, Heiner Fisher, Eva Trichopoulou, Antonia Georgila, Christina Trichopoulos, Dimitrios Palli, Domenico Krogh, Vittorio Tumino, Rosario Vineis, Paolo Quiros, Jose Ramon and Sala, Nuria Martinez-Garcia, Carmen Dorronsoro, Miren and Chirlaque, Maria-Dolores Barricarte, Aurelio van Duijnhoven, Franzel J. B. Bueno-de-Mesquita, H. B. van Gils, Carla H. and Peeters, Petra H. M. Hallmans, Goran Lenner, Per Bingham, Sheila Khaw, Kay Tee Key, Tim J. Travis, Ruth C. and Ferrari, Pietro Jenab, Mazda Riboli, Elio Kaaks, Rudolf
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Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also suggests a role of ghrelin in cancer development. We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition, to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor-binding protein 3 and breast cancer risk. Pair-wise tagging was used to select the 15 polymorphisms that represent the majority of common genetic variants across the GHRL and GHSR genes. A significant increase in breast cancer risk was observed in carriers of the GHRL rs171407-G allele (odds ratio: 1.2; 95% confidence interval: 1.0-1.4; P = 0.02). The GHRL single-nucleotide polymorphism rs375577 was associated with a 5% increase in IGF-I levels (P = 0.01). A number of GHRL and GHSR polymorphisms were associated with body mass index (BMI) and height (P between < 0.01 and 0.04). The false-positive report probability (FPRP) approach suggests that these results are noteworthy (FPRP < 0.20). The results presented here add to a growing body of evidence that GHRL variations are associated with BMI. Furthermore, we have observed evidence for association of GHRL polymorphisms with circulating IGF-I levels and with breast cancer risk. These associations, however, might also be due to chance findings and further large studies are needed to confirm our results.
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- 2008
43. TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: A prospective study
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Gormally, Emmanuelle Vineis, Paolo Matullo, Giuseppe Veglia, Fabrizio Caboux, Elodie Le Roux, Emilie Peluso, Marco and Garte, Seymour Guarrera, Simonetta Munnia, Armelle Airoldi, Luisa Autrup, Herman Malaveille, Christian Dunning, Alison and Overvad, Kim Tjonneland, Anne Lund, Eiliv and Clavel-Chapelon, Francoise Boeing, Heiner Trichopoulou, Antonia and Palli, Domenico Krogh, Vittorio Tumino, Rosario Panico, Salvatore Bueno-de-Mesquita, H. Bas Peeters, Petra H. Pera, Guillem Martinez, Carmen Dorronsoro, Miren Barricarte, Aurelio Navarro, Carmen Quiros, Jose Ramon Hallmans, Goran and Day, Nicholas E. Key, Timothy J. Saracci, Rodolfo Kaaks, Rudolf Riboli, Elio Hainaut, Pierre
- Abstract
In cancer patients, plasma often contains mutant DNA released by cancer cells. We have assessed the significance of plasma DNA mutations for subsequent cancer development in healthy subjects in a large longitudinal prospective study. The European Prospective Investigation into Cancer and Nutrition study was analyzed with a nested case-control design. Cases were nonsmokers or ex-smokers for > 10 years and newly diagnosed with lung, bladder, or upper aerodigestive tract cancers or leukemia accrued after a median follow-up of 6.3 years. Controls were matched 2:1 for follow-up, age, sex, area of recruitment, and smoking status. KRAS2 mutations were detected by mutant-enriched PCR and sequencing (n = 1,098). TP53 mutations were detected by denaturing high-performance liquid chromatography, temporal temperature gradient electrophoresis, and sequencing (n = 550). KRAS2 or TP53 mutations were detected in 13 of 1,098 (1.2%) and 20 of 550 (3.6%) subjects, respectively, 16 of whom developed cancer on average after 18.3 months of follow-up. Among 137 subjects who developed bladder cancer, 5 had KRAS2 mutations [odds ratio (OR), 4.25; 95% confidence interval (95% CI), 1.27-14.15] and 7 had TP53 mutations (OR, 1.81; 95% Cl, 0.66-4.97). There was a nonsignificant trend for association between TP53 mutations and bulky adducts in lymphocyte DNA (OR, 2.78; 95% Cl, 0.64-12.17). This is the first report of TP53 or KRAS2 mutations in the plasma of healthy subjects in a prospective study, suggesting that KRAS2 mutation is detectable ahead of bladder cancer diagnosis. TP53 mutation may be associated with environmental exposures. These observations have implications for monitoring early steps of carcinogenesis.
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- 2006
44. Association between different obesity measures and the risk of stroke in the EPIC Spanish cohort
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Abete, Itziar, primary, Arriola, Larraitz, additional, Etxezarreta, Nerea, additional, Mozo, Imanol, additional, Moreno-Iribas, Conchi, additional, Amiano, Pilar, additional, Egüés, Nerea, additional, Goyenechea, Estibaliz, additional, de Munain, Adolfo Lopez, additional, Martinez, Maite, additional, Travier, Noemi, additional, Navarro, Carmen, additional, Chirlaque, Maria-Dolores, additional, Tormo, Maria-Jose, additional, Gavrila, Diana, additional, Huerta, Jose Maria, additional, Sánchez, María-José, additional, Molina-Montes, Esther, additional, Requena, Mar, additional, Jiménez-Hernández, Maria-Dolores, additional, Ardanaz, Eva, additional, Barricarte, Aurelio, additional, Quiros, Jose Ramon, additional, Rodriguez, Laudina, additional, and Dorronsoro, Miren, additional
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- 2014
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45. Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein-Barr Virus Status-Defined Subgroups
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Urayama, Kevin Y., Jarrett, Ruth F., Hjalgrim, Henrik, Diepstra, Arjan, Kamatani, Yoichiro, Chabrier, Amelie, Gaborieau, Valerie, Boland, Anne, Nieters, Alexandra, Becker, Nikolaus, Foretova, Lenka, Benavente, Yolanda, Maynadie, Marc, Staines, Anthony, Shield, Lesley, Lake, Annette, Montgomery, Dorothy, Taylor, Malcolm, Smedby, Karin Ekstrom, Amini, Rose-Marie, Adami, Hans-Olov, Glimelius, Bengt, Feenstra, Bjarke, Nolte, Ilja M., Visser, Lydia, van Imhoff, Gustaaf W., Lightfoot, Tracy, Cocco, Pierluigi, Kiemeney, Lambertus, Vermeulen, Sita H., Holcatova, Ivana, Vatten, Lars, Macfarlane, Gary J., Thomson, Peter, Conway, David I., Benhamou, Simone, Agudo, Antonio, Healy, Claire M., Overvad, Kim, Tjonneland, Anne, Melin, Beatrice, Canzian, Federico, Khaw, Kay-Tee, Travis, Ruth C., Peeters, Petra H. M., Gonzalez, Carlos A., Quiros, Jose Ramon, Sanchez, Maria-Jose, Maria Huerta, Jose, Ardanaz, Eva, Dorronsoro, Miren, Clavel-Chapelon, Francoise, Bueno-de-Mesquita, H. Bas, Riboli, Elio, Roman, Eve, Boffetta, Paolo, de Sanjose, Silvia, Zelenika, Diana, Melbye, Mads, van den Berg, Anke, Lathrop, Mark, Brennan, Paul, McKay, James D., Urayama, Kevin Y., Jarrett, Ruth F., Hjalgrim, Henrik, Diepstra, Arjan, Kamatani, Yoichiro, Chabrier, Amelie, Gaborieau, Valerie, Boland, Anne, Nieters, Alexandra, Becker, Nikolaus, Foretova, Lenka, Benavente, Yolanda, Maynadie, Marc, Staines, Anthony, Shield, Lesley, Lake, Annette, Montgomery, Dorothy, Taylor, Malcolm, Smedby, Karin Ekstrom, Amini, Rose-Marie, Adami, Hans-Olov, Glimelius, Bengt, Feenstra, Bjarke, Nolte, Ilja M., Visser, Lydia, van Imhoff, Gustaaf W., Lightfoot, Tracy, Cocco, Pierluigi, Kiemeney, Lambertus, Vermeulen, Sita H., Holcatova, Ivana, Vatten, Lars, Macfarlane, Gary J., Thomson, Peter, Conway, David I., Benhamou, Simone, Agudo, Antonio, Healy, Claire M., Overvad, Kim, Tjonneland, Anne, Melin, Beatrice, Canzian, Federico, Khaw, Kay-Tee, Travis, Ruth C., Peeters, Petra H. M., Gonzalez, Carlos A., Quiros, Jose Ramon, Sanchez, Maria-Jose, Maria Huerta, Jose, Ardanaz, Eva, Dorronsoro, Miren, Clavel-Chapelon, Francoise, Bueno-de-Mesquita, H. Bas, Riboli, Elio, Roman, Eve, Boffetta, Paolo, de Sanjose, Silvia, Zelenika, Diana, Melbye, Mads, van den Berg, Anke, Lathrop, Mark, Brennan, Paul, and McKay, James D.
- Abstract
Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein-Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation in an independent replication series, to identify common genetic variants associated with total cHL and subtypes defined by tumor EBV status. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) assuming a log-additive genetic model for the variants. All statistical tests were two-sided. Two novel loci associated with total cHL irrespective of EBV status were identified in the major histocompatibility complex region; one resides adjacent to MICB (rs2248462: OR = 0.61, 95% CI = 0.53 to 0.69, P = 1.3 x 10(-13)) and the other at HLA-DRA (rs2395185: OR = 0.56, 95% CI = 0.50 to 0.62, P = 8.3 x 10(-25)) with both results confirmed in an independent replication series. Consistent with previous reports, associations were found between EBV-positive cHL and genetic variants within the class I region (rs2734986, HLA-A: OR = 2.45, 95% CI = 2.00 to 3.00, P = 1.2 x 10(-15); rs6904029, HCG9: OR = 0.46, 95% CI = 0.36 to 0.59, P = 5.5 x 10(-10)) and between EBV-negative cHL and rs6903608 within the class II region (rs6903608, HLA-DRA: OR = 2.08, 95% CI = 1.84 to 2.35, P = 6.1 x 10(-31)). The association between rs6903608 and EBV-negative cHL was confined to the nodular sclerosis histological subtype. Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x 10(-9)), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear. Notably, one additional psoriasis-associated variant, rs27524 (5q15, ERAP1), showed evidence of an association with cHL in the genome-wide association study
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- 2012
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46. Validity of a short questionnaire to assess physical activity in 10 European countries
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Peters, Tricia, Brage, Soren, Westgate, Kate, Franks, Paul W., Gradmark, Anna, Diaz, Maria Jose Tormo, Huerta, Jose Maria, Bendinelli, Benedetta, Vigl, Mattheaus, Boeing, Heiner, Wendel-Vos, Wanda, Spijkerman, Annemieke, Benjaminsen-Borch, Kristin, Valanou, Elisavet, Guillain, Blandine de Lauzon, Clavel-Chapelon, Francoise, Sharp, Stephen, Kerrison, Nicola, Langenberg, Claudia, Arriola, Larraitz, Barricarte, Aurelio, Gonzales, Carlos, Grioni, Sara, Kaaks, Rudolf, Key, Timothy, Khaw, Kay Tee, May, Anne, Nilsson, Peter, Norat, Teresa, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quiros, Jose Ramon, Ricceri, Fulvio, Sanchez, Maria-Jose, Slimani, Nadia, Tjonneland, Anne, Tumino, Rosario, Feskens, Edith, Riboli, Elio, Ekelund, Ulf, Wareham, Nick, Peters, Tricia, Brage, Soren, Westgate, Kate, Franks, Paul W., Gradmark, Anna, Diaz, Maria Jose Tormo, Huerta, Jose Maria, Bendinelli, Benedetta, Vigl, Mattheaus, Boeing, Heiner, Wendel-Vos, Wanda, Spijkerman, Annemieke, Benjaminsen-Borch, Kristin, Valanou, Elisavet, Guillain, Blandine de Lauzon, Clavel-Chapelon, Francoise, Sharp, Stephen, Kerrison, Nicola, Langenberg, Claudia, Arriola, Larraitz, Barricarte, Aurelio, Gonzales, Carlos, Grioni, Sara, Kaaks, Rudolf, Key, Timothy, Khaw, Kay Tee, May, Anne, Nilsson, Peter, Norat, Teresa, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quiros, Jose Ramon, Ricceri, Fulvio, Sanchez, Maria-Jose, Slimani, Nadia, Tjonneland, Anne, Tumino, Rosario, Feskens, Edith, Riboli, Elio, Ekelund, Ulf, and Wareham, Nick
- Abstract
To accurately examine associations of physical activity (PA) with disease outcomes, a valid method of assessing free-living activity is required. We examined the validity of a brief PA questionnaire (PAQ) used in the European Prospective Investigation into Cancer and Nutrition (EPIC). PA energy expenditure (PAEE) and time spent in moderate and vigorous physical activity (MVPA) was measured in 1,941 healthy individuals from 10 European countries using individually-calibrated combined heart-rate and movement sensing. Participants also completed the short EPIC-PAQ, which refers to past year's activity. Pearson (r) and Spearman (sigma) correlation coefficients were calculated for each country, and random effects meta-analysis was used to calculate the combined correlation across countries to estimate the validity of two previously- and one newly-derived ordered, categorical PA indices ("Cambridge index", "total PA index", and "recreational index") that categorized individuals as inactive, moderately inactive, moderately active, or active. The strongest associations with PAEE and MVPA were observed for the Cambridge index (r = 0.33 and r = 0.25, respectively). No significant heterogeneity by country was observed for this index (I-2 = 36.3%, P = 0.12; I-2 = 0.0%, P = 0.85), whereas heterogeneity was suggested for other indices (I-2 > 48%, P < 0.05, I-2 > 47%, P < 0.05). PAEE increased linearly across self-reported PA categories (P for trend < 0.001), with an average difference of approximately 460 kJ/d for men and 365 kJ/d for women, between categories of the Cambridge index. The EPIC-PAQ is suitable for categorizing European men and women into four distinct categories of overall physical activity. The difference in PAEE between categories may be useful when estimating effect sizes from observational research.
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- 2012
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47. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition
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Ros, Martine M., Bueno-de-Mesquita, H. Bas, Kampman, Ellen, Aben, Katja K. H., Buechner, Frederike L., Jansen, Eugene H. J. M., van Gils, Carla H., Egevad, Lars, Overvad, Kim, Tjonneland, Anne, Roswall, Nina, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Perquier, Florence, Kaaks, Rudolf, Chang-Claude, Jenny, Weikert, Steffen, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Dilis, Vardis, Palli, Domenico, Pala, Valeria, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Peeters, Petra H. M., Gram, Inger T., Skeie, Guri, Huerta, Jose Maria, Barricarte, Aurelio, Quiros, Jose Ramon, Sanchez, Maria Jose, Buckland, Genevieve, Larranaga, Nerea, Ehrnstroem, Roy, Wallstroem, Peter, Ljungberg, Börje, Hallmans, Göran, Key, Timothy J., Allen, Naomi E., Khaw, Kay-Tee, Wareham, Nick, Brennan, Paul, Riboli, Elio, Kiemeney, Lambertus A., Ros, Martine M., Bueno-de-Mesquita, H. Bas, Kampman, Ellen, Aben, Katja K. H., Buechner, Frederike L., Jansen, Eugene H. J. M., van Gils, Carla H., Egevad, Lars, Overvad, Kim, Tjonneland, Anne, Roswall, Nina, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Perquier, Florence, Kaaks, Rudolf, Chang-Claude, Jenny, Weikert, Steffen, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Dilis, Vardis, Palli, Domenico, Pala, Valeria, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Peeters, Petra H. M., Gram, Inger T., Skeie, Guri, Huerta, Jose Maria, Barricarte, Aurelio, Quiros, Jose Ramon, Sanchez, Maria Jose, Buckland, Genevieve, Larranaga, Nerea, Ehrnstroem, Roy, Wallstroem, Peter, Ljungberg, Börje, Hallmans, Göran, Key, Timothy J., Allen, Naomi E., Khaw, Kay-Tee, Wareham, Nick, Brennan, Paul, Riboli, Elio, and Kiemeney, Lambertus A.
- Abstract
Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. Results: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma beta-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC. Conclusions: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC.
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- 2012
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48. Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: Etiological factors or risk markers?
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Lukanova, Annekatrin, primary, Becker, Susen, additional, Hüsing, Anika, additional, Schock, Helena, additional, Fedirko, Veronika, additional, Trepo, Elisabeth, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Lagiou, Pagona, additional, Benetou, Vassiliki, additional, Trichopoulos, Dimitrios, additional, Nöthlings, Ute, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Dossus, Laure, additional, Teucher, Birgit, additional, Boeing, Heiner, additional, Aleksandrova, Krasimira, additional, Palli, Domenico, additional, Pala, Valeria, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Bueno-de-Mesquita, H. Bas, additional, Siersema, Peter D., additional, Peeters, Petra H.M., additional, Quiros, Jose Ramon, additional, Duell, Eric J., additional, Molina-Montes, Esther, additional, Chirlaque, Maria-Dolores, additional, Gurrea, Aurelio Barricarte, additional, Dorronsoro, Miren, additional, Lindkvist, Björn, additional, Johansen, Dorthe, additional, Werner, Mårten, additional, Sund, Malin, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Key, Timothy J., additional, Travis, Ruth C., additional, Rinaldi, Sabina, additional, Romieu, Isabelle, additional, Gunter, Marc J., additional, Riboli, Elio, additional, Jenab, Mazda, additional, and Kaaks, Rudolf, additional
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- 2013
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49. Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study
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Ritte, Rebecca, Tikk, Kaja, Lukanova, Annekatrin, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dossus, Laure, Fournier, Agnès, Clavel-Chapelon, Françoise, Grote, Verena, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Berrino, Franco, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Quirós, José Ramón, Buckland, Genevieve, Molina-Montes, Esther, Chirlaque, María-Dolores, Ardanaz, Eva, Amiano, Pilar, Bueno-de-Mesquita, H Bas, van Gils, Carla H, Peeters, Petra HM, Wareham, Nick, Khaw, Kay-Tee, Key, Timothy J, Travis, Ruth C, Weiderpass, Elisabete, Dumeaux, Vanessa, Lund, Eliv, Sund, Malin, Andersson, Anne, Romieu, Isabelle, Rinaldi, Sabina, Vineis, Paulo, Merritt, Melissa A, Riboli, Elio, and Kaaks, Rudolf
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ER-receptor ,PR-receptor ,Reproductive factors ,Risk factors ,Menopause ,Parity ,Oral contraceptive ,Breast cancer - Abstract
Background: The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain. Methods: Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term childbirth, breastfeeding, age at menopause, ever having an abortion and use of oral contraceptives [OC]) with risk of ER-PR- (n = 998) and ER+PR+ (n = 3,567) breast tumors. Results: A later first full-term childbirth was associated with increased risk of ER+PR+ tumors but not with risk of ER-PR- tumors (≥35 vs. ≤19 years HR: 1.47 [95% CI 1.15-1.88] ptrend < 0.001 for ER+PR+ tumors; ≥35 vs. ≤19 years HR: 0.93 [95% CI 0.53-1.65] ptrend = 0.96 for ER-PR- tumors; P het = 0.03). The risk associations of menarcheal age, and time period between menarche and first full-term childbirth with ER-PR-tumors were in the similar direction with risk of ER+PR+ tumors (phet = 0.50), although weaker in magnitude and statistically only borderline significant. Other parity related factors such as ever a full-term birth, number of births, age- and time since last birth were associated only with ER+PR+ malignancies, however no statistical heterogeneity between breast cancer subtypes was observed. Breastfeeding and OC use were generally not associated with breast cancer subtype risk. Conclusion: Our study provides possible evidence that age at menarche, and time between menarche and first full-term childbirth may be associated with the etiology of both HR-negative and HR-positive malignancies, although the associations with HR-negative breast cancer were only borderline significant.
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- 2013
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50. Adiposity, Hormone Replacement Therapy Use and Breast Cancer Risk by Age and Hormone Receptor Status: A Large Prospective Cohort Study
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Ritte, Rebecca, Lukanova, Annekatrin, Berrino, Franco, Dossus, Laure, Tjønneland, Anne, Olsen, Anja, Overvad, Thure Filskov, Overvad, Kim, Clavel-Chapelon, Françoise, Fournier, Agnès, Fagherazzi, Guy, Rohrmann, Sabine, Teucher, Birgit, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Quirós, José Ramón, Buckland, Genevieve, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Sund, Malin, Lenner, Per, Bueno-de-Mesquita, Bas, van Gils, Carla H, Peeters, Petra HM, Krum-Hansen, Sanda, Gram, Inger Torhild, Lund, Eiliv, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E, Key, Timothy J, Romieu, Isabelle, Rinaldi, Sabina, Siddiq, Afshan, Riboli, Elio, Kaaks, Rudolf, Lagiou, Pagona, Trichopoulos, Dimitrios, and Cox, David
- Abstract
Introduction: Associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association of body mass index (BMI) with hormone-receptor negative malignancies, and possible interactions by hormone replacement therapy (HRT) use. Methods: Within the European EPIC cohort, Cox proportional hazards models were used to describe the relationship of BMI, waist and hip circumferences with risk of estrogen-receptor (ER) negative and progesterone-receptor (PR) negative (n = 1,021) and ER+PR+ (n = 3,586) breast tumors within five-year age bands. Among postmenopausal women, the joint effects of BMI and HRT use were analyzed. Results: For risk of ER-PR- tumors, there was no association of BMI across the age bands. However, when analyses were restricted to postmenopausal HRT never users, a positive risk association with BMI (third versus first tertile HR = 1.47 (1.01 to 2.15)) was observed. BMI was inversely associated with ER+PR+ tumors among women aged \(≤49 years (per 5 kg/m^2 increase, HR = 0.79 (95\%CI 0.68 to 0.91))\), and positively associated with risk among women ≥65 years (HR = 1.25 (1.16 to 1.34)). Adjusting for BMI, waist and hip circumferences showed no further associations with risks of breast cancer subtypes. Current use of HRT was significantly associated with an increased risk of receptor-negative (HRT current use compared to HRT never use HR: 1.30 (1.05 to 1.62)) and positive tumors (HR: 1.74 (1.56 to 1.95)), although this risk increase was weaker for ER-PR- disease \((P_{het} = 0.035)\). The association of HRT was significantly stronger in the leaner women \((BMI ≤22.5 kg/m^2)\) than for more overweight women \((BMI ≥25.9 kg/m^2)\) for, both, ER-PR- (HR: 1.74 (1.15 to 2.63)) and ER+PR+ (HR: 2.33 (1.84 to 2.92)) breast cancer and was not restricted to any particular HRT regime. Conclusions: An elevated BMI may be positively associated with risk of ER-PR- tumors among postmenopausal women who never used HRT. Furthermore, postmenopausal HRT users were at an increased risk of ER-PR- as well as ER+PR+ tumors, especially among leaner women. For hormone-receptor positive tumors, but not for hormone-receptor negative tumors, our study confirms an inverse association of risk with BMI among young women of premenopausal age. Our data provide evidence for a possible role of sex hormones in the etiology of hormone-receptor negative tumors.
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- 2012
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