123 results on '"Quiros, J. Ramon"'
Search Results
2. A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC
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Papadimitriou, Nikos, Bouras, Emmanouil, van den Brandt, Piet A., Muller, David C., Papadopoulou, Areti, Heath, Alicia K., Critselis, Elena, Gunter, Marc J., Vineis, Paolo, Ferrari, Pietro, Weiderpass, Elisabete, Boeing, Heiner, Bastide, Nadia, Merritt, Melissa A., Lopez, David S., Bergmann, Manuela M., Perez-Cornago, Aurora, Schulze, Matthias, Skeie, Guri, Srour, Bernard, Eriksen, Anne Kirstine, Boden, Stina, Johansson, Ingegerd, Nøst, Therese Haugdahl, Lukic, Marco, Ricceri, Fulvio, Ericson, Ulrika, Huerta, José María, Dahm, Christina C., Agnoli, Claudia, Amiano, Pilar Exezarreta, Tjønneland, Anne, Gurrea, Aurelio Barricarte, Bueno-de-Mesquita, Bas, Ardanaz, Eva, Berntsson, Jonna, Sánchez, Maria-Jose, Tumino, Rosario, Panico, Salvatore, Katzke, Verena, Jakszyn, Paula, Masala, Giovanna, Derksen, Jeroen W.G., Quirós, J. Ramón, Severi, Gianluca, Cross, Amanda J., Riboli, Ellio, Tzoulaki, Ioanna, and Tsilidis, Konstantinos K.
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- 2022
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3. Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes : InterAct case-cohort study in eight European countries
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Zheng, Ju-Sheng, Sharp, Stephen J, Imamura, Fumiaki, Chowdhury, Rajiv, Gundersen, Thomas E, Steur, Marinka, Sluijs, Ivonne, van der Schouw, Yvonne T, Agudo, Antonio, Aune, Dagfinn, Barricarte, Aurelio, Boeing, Heiner, Chirlaque, María-Dolores, Dorronsoro, Miren, Freisling, Heinz, El-Fatouhi, Douae, Franks, Paul W, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J, Kyrø, Cecilie, Katzke, Verena, Kühn, Tilman, Khaw, Kay-Tee, Laouali, Nasser, Masala, Giovanna, Nilsson, Peter M, Overvad, Kim, Panico, Salvatore, Papier, Keren, Quirós, J Ramón, Rolandsson, Olov, Redondo-Sánchez, Daniel, Ricceri, Fulvio, Schulze, Matthias B, Spijkerman, Annemieke M W, Tjønneland, Anne, Tong, Tammy Y N, Tumino, Rosario, Weiderpass, Elisabete, Danesh, John, Butterworth, Adam S, Riboli, Elio, Forouhi, Nita G, and Wareham, Nicholas J
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- 2020
4. On the use of the healthy lifestyle index to investigate specific disease outcomes
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Viallon, Vivian, primary, Freisling, Heinz, additional, Matta, Komodo, additional, Dahm, Christina, additional, Tjonneland, Anne, additional, Erisken, Anne Kirstine, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Mattias, additional, Masala, Giovanna, additional, Tagliabue, Giovanna, additional, Simeon, Vittorio, additional, Tumino, Rosario, additional, Milani, Lorenzo, additional, Derksen, Jeroen W.G., additional, Schouw, Yvonne T. van der, additional, Nøst, Therese Haugdahl, additional, Borch, Kristin Benjaminsen, additional, Sandanger, Torkjel, additional, Quiros, J. Ramon, additional, Barranco, Miguel Rodríguez, additional, Bonet, Catalina, additional, Aizpurua-Atxega, Amaia, additional, Cirera, Lluís, additional, Guevara, Marcela, additional, Sundström, Björn, additional, Winkvist, Anna, additional, Heath, Alicia K, additional, Gunter, Marc J., additional, Weiderpass, Elisabete, additional, Johansson, Mattias, additional, Ferrari, Pietro, additional, and Naansen, Østergaard, additional
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- 2023
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5. Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study
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Murphy, Neil, Ward, Heather A., Jenab, Mazda, Rothwell, Joseph A., Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Kvaskoff, Marina, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Weiderpass, Elisabete, Skeie, Guri, Borch, Kristin Benjaminsen, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Dahm, Christina C., Jakszyn, Paula, Sánchez, Maria-Jose, Gil, Leire, Huerta, José M., Barricarte, Aurelio, Quirós, J. Ramón, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E., Trichopoulou, Antonia, La Vecchia, Carlo, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Fasanelli, Francesca, Panico, Salvatore, Bueno-de-Mesquita, Bas, Peeters, Petra H., Gylling, Björn, Myte, Robin, Jirström, Karin, Berntsson, Jonna, Xue, Xiaonan, Riboli, Elio, Cross, Amanda J., and Gunter, Marc J.
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- 2019
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6. DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
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Ambatipudi, Srikant, Horvath, Steve, Perrier, Flavie, Cuenin, Cyrille, Hernandez-Vargas, Hector, Le Calvez-Kelm, Florence, Durand, Geoffroy, Byrnes, Graham, Ferrari, Pietro, Bouaoun, Liacine, Sklias, Athena, Chajes, Véronique, Overvad, Kim, Severi, Gianluca, Baglietto, Laura, Clavel-Chapelon, Françoise, Kaaks, Rudolf, Barrdahl, Myrto, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Masala, Giovanna, Agnoli, Claudia, Polidoro, Silvia, Tumino, Rosario, Panico, Salvatore, Dollé, Martijn, Peeters, Petra H.M., Onland-Moret, N. Charlotte, Sandanger, Torkjel M., Nøst, Therese H., Weiderpass, Elisabete, Quirós, J. Ramón, Agudo, Antonio, Rodriguez-Barranco, Miguel, Huerta Castaño, José María, Barricarte, Aurelio, Fernández, Ander Matheu, Travis, Ruth C., Vineis, Paolo, Muller, David C., Riboli, Elio, Gunter, Marc, Romieu, Isabelle, and Herceg, Zdenko
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- 2017
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7. Prospective association of liver function biomarkers with development of hepatobiliary cancers
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Stepien, Magdalena, Fedirko, Veronika, Duarte-Salles, Talita, Ferrari, Pietro, Freisling, Heinz, Trepo, Elisabeth, Trichopoulou, Antonia, Bamia, Christina, Weiderpass, Elisabete, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Racine, Antoine, Kühn, Tilman, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Lagiou, Pagona, Benetou, Vassiliki, Trichopoulos, Dimitrios, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Bueno-de-Mesquita, H. Bas., Peeters, Petra H., Lund, Eiliv, Quirós, J. Ramón, Nápoles, Osmel Companioni, Sánchez, María-José, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Ohlsson, Bodil, Sjöberg, Klas, Werner, Mårten, Nystrom, Hanna, Khaw, Kay-Tee, Key, Timothy J., Gunter, Marc, Cross, Amanda, Riboli, Elio, Romieu, Isabelle, and Jenab, Mazda
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- 2016
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8. Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
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Bakker, Marije F, Peeters, Petra HM, Klaasen, Veronique M, Bueno-de-Mesquita, H Bas, Jansen, Eugene HJM, Ros, Martine M, Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie-Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María-José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C, Key, Timothy J, Khaw, Kay-Tee, Wareham, Nick, Riboli, Elio, and van Gils, Carla H
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- 2016
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9. Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study
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Merritt, Melissa A, Tzoulaki, Ioanna, van den Brandt, Piet A, Schouten, Leo J, Tsilidis, Konstantinos K, Weiderpass, Elisabete, Patel, Chirag J, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, His, Mathilde, Dartois, Laureen, Boutron-Ruault, Marie-Christine, Fortner, Renée T, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Bueno-de-Mesquita, H Bas, Onland-Moret, N Charlotte, Peeters, Petra H, Skeie, Guri, Jareid, Mie, Quirós, J Ramón, Obón-Santacana, Mireia, Sánchez, María-José, Chamosa, Saioa, Huerta, José M, Barricarte, Aurelio, Dias, Joana A, Sonestedt, Emily, Idahl, Annika, Lundin, Eva, Wareham, Nicholas J, Khaw, Kay-Tee, Travis, Ruth C, Ferrari, Pietro, Riboli, Elio, and Gunter, Marc J
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- 2016
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10. Vegetable and fruit consumption and the risk of hormone receptor–defined breast cancer in the EPIC cohort
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Emaus, Marleen J, Peeters, Petra HM, Bakker, Marije F, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Romieu, Isabelle, Ferrari, Pietro, Dossus, Laure, Boutron-Ruault, Marie Christine, Baglietto, Laura, Fortner, Renée T, Kaaks, Rudolf, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Polidoro, Silvia, Skeie, Guri, Lund, Eiliv, Weiderpass, Elisabete, Quirós, J Ramón, Travier, Noémie, Sánchez, María-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Winkvist, Anna, Wennberg, Maria, Bueno-de-Mesquita, H Bas, Khaw, Kay-Tee, Travis, Ruth C, Key, Timothy J, Aune, Dagfinn, Gunter, Marc, Riboli, Elio, and van Gils, Carla H
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- 2016
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11. The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition
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Aleksandrova, Krasimira, Bamia, Christina, Drogan, Dagmar, Lagiou, Pagona, Trichopoulou, Antonia, Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Bueno-de-Mesquita, H Bas, Pischon, Tobias, Tsilidis, Kostas, Overvad, Kim, Tjønneland, Anne, Bouton-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Kühn, Tilman, Tsironis, Christos, Papatesta, Eleni-Maria, Saitakis, George, Palli, Domenico, Panico, Salvatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H, Weiderpass, Elisabete, Lukic, Marko, Braaten, Tonje, Quirós, J Ramón, Luján-Barroso, Leila, Sánchez, María-José, Chilarque, Maria-Dolores, Ardanas, Eva, Dorronsoro, Miren, Nilsson, Lena Maria, Sund, Malin, Wallström, Peter, Ohlsson, Bodil, Bradbury, Kathryn E, Khaw, Kay-Tee, Wareham, Nick, Stepien, Magdalena, Duarte-Salles, Talita, Assi, Nada, Murphy, Neil, Gunter, Marc J, Riboli, Elio, Boeing, Heiner, and Trichopoulos, Dimitrios
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- 2015
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12. Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC)
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Ekelund, Ulf, Ward, Heather A, Norat, Teresa, Luan, Jian’an, May, Anne M, Weiderpass, Elisabete, Sharp, Stephen J, Overvad, Kim, Østergaard, Jane Nautrup, Tjønneland, Anne, Johnsen, Nina Føns, Mesrine, Sylvie, Fournier, Agnès, Fagherazzi, Guy, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Li, Kuanrong, Kaaks, Rudolf, Ferrari, Pietro, Licaj, Idlir, Jenab, Mazda, Bergmann, Manuela, Boeing, Heiner, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H, Monnikhof, Evelyn, Bueno-de-Mesquita, H Bas, Quirós, J Ramón, Agudo, Antonio, Sánchez, María-José, Huerta, José María, Ardanaz, Eva, Arriola, Larraitz, Hedblad, Bo, Wirfält, Elisabet, Sund, Malin, Johansson, Mattias, Key, Timothy J, Travis, Ruth C, Khaw, Kay-Tee, Brage, Søren, Wareham, Nicholas J, and Riboli, Elio
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- 2015
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13. Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study
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Forouhi, Nita G, Koulman, Albert, Sharp, Stephen J, Imamura, Fumiaki, Kröger, Janine, Schulze, Matthias B, Crowe, Francesca L, Huerta, José María, Guevara, Marcela, Beulens, Joline WJ, van Woudenbergh, Geertruida J, Wang, Laura, Summerhill, Keith, Griffin, Julian L, Feskens, Edith JM, Amiano, Pilar, Boeing, Heiner, Clavel-Chapelon, Françoise, Dartois, Laureen, Fagherazzi, Guy, Franks, Paul W, Gonzalez, Carlos, Jakobsen, Marianne Uhre, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay-Tee, Kühn, Tilman, Mattiello, Amalia, Nilsson, Peter M, Overvad, Kim, Pala, Valeria, Palli, Domenico, Quirós, J Ramón, Rolandsson, Olov, Roswall, Nina, Sacerdote, Carlotta, Sánchez, María-José, Slimani, Nadia, Spijkerman, Annemieke MW, Tjonneland, Anne, Tormo, Maria-José, Tumino, Rosario, van der A, Daphne L, van der Schouw, Yvonne T, Langenberg, Claudia, Riboli, Elio, and Wareham, Nicholas J
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- 2014
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14. Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition
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Merritt, Melissa A., Riboli, Elio, Weiderpass, Elisabete, Tsilidis, Konstantinos K., Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Dossus, Laure, Fagherazzi, Guy, Baglietto, Laura, Fortner, Renée T., Ose, Jennifer, Steffen, Annika, Boeing, Heiner, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Lagiou, Pagona, Masala, Giovanna, Sieri, Sabina, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, H. B(as), Onland-Moret, N. Charlotte, Peeters, Petra H., Hjartåker, Anette, Gram, Inger Torhild, Quirós, J. Ramón, Obón-Santacana, Mireia, Molina-Montes, Esther, Huerta Castaño, José María, Ardanaz, Eva, Chamosa, Saioa, Sonestedt, Emily, Idahl, Annika, Lundin, Eva, Khaw, Kay-Tee, Wareham, Nicholas, Travis, Ruth C., Rinaldi, Sabina, Romieu, Isabelle, Chajes, Veronique, and Gunter, Marc J.
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- 2014
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15. Non-invasive risk scores for prediction of type 2 diabetes (EPIC-InterAct): a validation of existing models
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Kengne, Andre Pascal, Beulens, Joline WJ, Peelen, Linda M, Moons, Karel GM, van der Schouw, Yvonne T, Schulze, Matthias B, Spijkerman, Annemieke MW, Griffin, Simon J, Grobbee, Diederick E, Palla, Luigi, Tormo, Maria-Jose, Arriola, Larraitz, Barengo, Noël C, Barricarte, Aurelio, Boeing, Heiner, Bonet, Catalina, Clavel-Chapelon, Françoise, Dartois, Laureen, Fagherazzi, Guy, Franks, Paul W, Huerta, José María, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay Tee, Li, Kuanrong, Mühlenbruch, Kristin, Nilsson, Peter M, Overvad, Kim, Overvad, Thure F, Palli, Domenico, Panico, Salvatore, Quirós, J Ramón, Rolandsson, Olov, Roswall, Nina, Sacerdote, Carlotta, Sánchez, María-José, Slimani, Nadia, Tagliabue, Giovanna, Tjønneland, Anne, Tumino, Rosario, van der A, Daphne L, Forouhi, Nita G, Sharp, Stephen J, Langenberg, Claudia, Riboli, Elio, and Wareham, Nicholas J
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- 2014
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16. Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
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Lujan-Barroso, Leila, González, Carlos Alberto, Slimani, Nadia, Obón-Santacana, Mireia, Ferrari, Pietro, Freisling, Heinz, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Racine, Antoine, Katzke, Verena, Kühn, Tilman, Tjønneland, Anne, Olsen, Anja, Quirós, J. Ramón, Sánchez-Cantalejo, Emilio, Amiano, Pilar, Navarro, Carmen, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Trichopoulou, Antonia, Bamia, Christina, Benetou, Vassiliki, Saieva, Calogero, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Mattiello, Amalia, Bueno-de-Mesquita, H. Bas, Siersema, Peter D., Numans, Mattijs E., Peeters, Petra H., Ericson, Ulrika, Wirfält, Elisabet, Sund, Malin, Johansson, Mattias, Weiderpass, Elisabete, Skeie, Guri, Riboli, Elio, Boeing, Heiner, and Duell, Eric J.
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- 2014
17. Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Aleksandrova, Krasimira, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Fedirko, Veronika, Kaaks, Rudolf, Lukanova, Annekatrin, van Duijnhoven, Fränzel J. B., Jansen, Eugene, Rinaldi, Sabina, Romieu, Isabelle, Ferrari, Pietro, Murphy, Neil, Gunter, Marc J., Riboli, Elio, Westhpal, Sabine, Overvad, Kim, Tjønneland, Anne, Halkjær, Jytte, Boutron-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, Agnoli, Claudia, Palli, Domenico, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H., Duell, Eric J., Molina-Montes, Esther, Quirós, J. Ramón, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Ljuslinder, Ingrid, Palmqvist, Richard, Travis, Ruth C., Khaw, Kay-Tee, Wareham, Nicholas, Pischon, Tobias, and Boeing, Heiner
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- 2014
18. Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study
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Michaud, Dominique S., Izard, Jacques, Rubin, Zachary, Johansson, Ingegerd, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Dossus, Laure, Kaaks, Rudolf, Katzke, Verena A., Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Naska, Androniki, Ziara, Giana, Vineis, Paolo, Grioni, Sara, Palli, Domenico, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H. M., Siersema, Peter D., Barricarte, Aurelio, Huerta, José-María, Molina-Montes, Esther, Dorronsoro, Miren, Quirós, J. Ramón, Duell, Eric J., Ohlsson, Bodil, Jeppsson, Bengt, Johansson, Anders, Lif, Pernilla, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Key, Tim J., Freisling, Heinz, Duarte-Salles, Talita, Stepien, Magdalena, Riboli, Elio, and Bueno-de-Mesquita, H. Bas
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- 2013
19. Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition
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Łuczyńska, Anna, Kaaks, Rudolf, Rohrmann, Sabine, Becker, Susen, Linseisen, Jakob, Buijsse, Brian, Overvad, Kim, Trichopoulou, Antonia, Valanou, Elisavet, Barmpitsioti, Antonia, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Panico, Salvatore, Bueno-de-Mesquita, H Bas, van Duijnhoven, Fränzel JB, Peeters, Petra HM, Vermeulen, Roel, Weiderpass, Elisabete, Brustad, Magritt, Skeie, Guri, González, Carlos A, Jakszyn, Paula, Quirós, J Ramón, Sánchez, María-José, Huerta, José María, Ardanaz, Eva, Melin, Beatrice, Johansson, Ann Sofie, Almquist, Martin, Malm, Johan, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C, Fedirko, Veronika, Romieu, Isabelle, Jenab, Mazda, Gallo, Valentina, Riboli, Elio, Vineis, Paolo, and Nieters, Alexandra
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- 2013
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20. Mediterranean diet and colorectal cancer risk: results from a European cohort
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Bamia, Christina, Lagiou, Pagona, Buckland, Genevieve, Grioni, Sara, Agnoli, Claudia, Taylor, Aliki J., Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Cottet, Vanessa, Boutron-Ruault, Marie-Christine, Morois, Sophie, Grote, Verena, Teucher, Birgit, Boeing, Heiner, Buijsse, Brian, Trichopoulos, Dimitrios, Adarakis, George, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Palli, Domenico, Bueno-de-Mesquita, H. Bas, van Duijnhoven, Fränzel J. B., Peeters, Petra H. M., Engeset, Dagrun, Skeie, Guri, Lund, Eiliv, Sánchez, Maria-José, Barricarte, Aurelio, Huerta, Jose-Maria, Quirós, J. Ramón, Dorronsoro, Miren, Ljuslinder, Ingrid, Palmqvist, Richard, Drake, Isabel, Key, Timothy J., Khaw, Kay-Tee, Wareham, Nick, Romieu, Isabelle, Fedirko, Veronika, Jenab, Mazda, Romaguera, Dora, Norat, Teresa, and Trichopoulou, Antonia
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- 2013
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21. Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC
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Travis, Ruth C., Allen, Naomi E., Appleby, Paul N., Price, Alison, Kaaks, Rudolf, Chang-Claude, Jenny, Boeing, Heiner, Aleksandrova, Krasimira, Tjønneland, Anne, Johnsen, Nina Føns, Overvad, Kim, Quirós, J. Ramón, González, Carlos A., Molina-Montes, Esther, Sánchez, Maria José, Larrañaga, Nerea, Castaño, José María Huerta, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick, Trichopoulou, Antonia, Karapetyan, Tina, Rafnsson, Snorri Bjorn, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H. Bas, Stattin, Pär, Johansson, Mattias, Fedirko, Veronika, Norat, Teresa, Siddiq, Afshan, Riboli, Elio, and Key, Timothy J.
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- 2012
22. Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort
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Chuang, Shu-Chun, Norat, Teresa, Murphy, Neil, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Boutron-Ruault, Marie Christine, Perquier, Florence, Dartois, Laureen, Kaaks, Rudolf, Teucher, Birgit, Bergmann, Manuela M, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Grioni, Sara, Sacerdote, Carlotta, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Peeters, Petra HM, Bueno-de-Mesquita, Bas, Ros, Martine M, Brustad, Magritt, Åsli, Lene Angell, Skeie, Guri, Quirós, J Ramón, González, Carlos A, Sánchez, María-José, Navarro, Carmen, Ardanaz Aicua, Eva, Dorronsoro, Miren, Drake, Isabel, Sonestedt, Emily, Johansson, Ingegerd, Hallmans, Göran, Key, Timothy, Crowe, Francesca, Khaw, Kay-Tee, Wareham, Nicholas, Ferrari, Pietro, Slimani, Nadia, Romieu, Isabelle, Gallo, Valentina, Riboli, Elio, and Vineis, Paolo
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- 2012
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23. Olive oil intake and mortality within the Spanish population (EPIC-Spain)
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Buckland, Genevieve, Mayén, Ana Lucia, Agudo, Antonio, Travier, Noemie, Navarro, Carmen, Huerta, José María, Chirlaque, María Dolores, Barricarte, Aurelio, Ardanaz, Eva, Moreno-Iribas, Conchi, Marin, Pilar, Quirós, J Ramón, Redondo, María-Luisa, Amiano, Pilar, Dorronsoro, Miren, Arriola, Larraitz, Molina, Esther, Sanchez, María-José, and Gonzalez, Carlos A
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- 2012
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24. Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival
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Johansson, Mattias, Fanidi, Anouar, Muller, David C., Bassett, Julie K., Midttun, Øivind, Vollset, Stein Emil, Travis, Ruth C., Palli, Domenico, Mattiello, Amalia, Sieri, Sabina, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Ljungberg, Börje, Hallmans, Göran, Weiderpass, Elisabete, Skeie, Guri, González, Carlos A., Dorronsoro, Miren, Peeters, Petra H., Bueno-de-Mesquita, H. B(as)., Ros, Martine M., Boutron Ruault, Marie-Christine, Fagherazzi, Guy, Clavel, Françoise, Sánchez, María-José, Gurrea, Aurelio Barricarte, Navarro, Carmen, Quiros, J. Ramon, Overvad, Kim, Tjønneland, Anne, Aleksandrova, Krassimira, Vineis, Paolo, Gunter, Marc J., Kaaks, Rudolf, Giles, Graham, Relton, Caroline, Riboli, Elio, Boeing, Heiner, Ueland, Per Magne, Severi, Gianluca, and Brennan, Paul
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- 2014
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25. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Morois, Sophie, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J Ramón, Sánchez-Cantalejo, Emilio, Navarro, Carmen, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Khaw, Kay-Tee, Allen, Naomi E, Key, Timothy J, Bueno-de-Mesquita, H Bas, Ros, Martine M, Numans, Mattijs E, Peeters, Petra HM, Trichopoulou, Antonia, Naska, Androniki, Dilis, Vardis, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Regner, Sara, Lindkvist, Björn, Johansson, Ingegerd, Hallmans, Göran, Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Lund, Eiliv, Weiderpass, Elisabete, Braaten, Tonje, Romieu, Isabelle, Ferrari, Pietro, Jenab, Mazda, Stenling, Roger, Aune, Dagfinn, Norat, Teresa, Riboli, Elio, and González, Carlos A
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- 2011
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26. Occupational Exposures, Environmental Tobacco Smoke, and Lung Cancer
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Veglia, Fabrizio, Vineis, Paolo, Overvad, Kim, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Linseisen, Jakob, Steindorf, Karen, Raaschou-Nielsen, Ole, Tjønneland, Anne, Gonzalez, Carlos A., Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Cirera, Lluis, Quiros, J. Ramon, Day, Nicholas E., Saracci, Rodolfo, and Riboli, Elio
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- 2007
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27. Relationship of Alcohol Intake and Sex Steroid Concentrations in Blood in Pre- and Post-Menopausal Women: The European Prospective Investigation into Cancer and Nutrition
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Rinaldi, S., Peeters, P. H. M., Bezemer, I. D., Dossus, L., Biessy, C., Sacerdote, C., Berrino, F., Panico, S., Palli, D., Tumino, R., Khaw, K. T., Bingham, S., Allen, N. E., Key, T., Jensen, M. K., Overvad, K., Olsen, A., Tjonneland, A., Amiano, P., Ardanaz, E., Agudo, A., Martinez-García, C., Quirós, J. Ramón, Tormo, M. J., Nagel, G., Linseisen, J., Boeing, H., Schulz, M., Grobbee, D. E., Bueno-De-Mesquita, H. B., Koliva, M., Kyriazi, G., Thrichopoulou, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Ferrari, P., Slimani, N., Saracci, R., Riboli, E., and Kaaks, R.
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- 2006
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28. Intake of Fruits and Vegetables and Risk of Cancer of the Upper Aero-Digestive Tract: The Prospective EPIC-Study
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Boeing, Heiner, Dietrich, Thomas, Hoffmann, Kurt, Pischon, Tobias, Ferrari, Pietro, Lahmann, Petra H., Boutron-Ruault, Marie Christine, Clavel-Chapelon, Francoise, Allen, Naomi, Key, Tim, Skeie, Guri, Lund, Eiliv, Olsen, Anja, Tjonneland, Anne, Overvad, Kim, Jensen, Majken K., Rohrmann, Sabine, Linseisen, Jakob, Trichopoulou, Antonia, Bamia, Christina, Psaltopoulou, Theodora, Weinehall, Lars, Johansson, Ingegerd, Sánchez, Maria-José, Jakszyn, Paula, Ardanaz, Eva, Amiano, Pilar, Chirlaque, Maria Dolores, Quirós, J. Ramón, Wirfalt, Elisabet, Berglund, Göran, Peeters, Petra H., Van Gils, Carla H., Bueno-De-Mesquita, H. Bas, Büchner, Frederike L., Berrino, Franco, Palli, Domenico, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Bingham, Sheila, Khaw, Kay-Tee, Slimani, Nadia, Norat, Teresa, Jenab, Mazda, and Riboli, Elio
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- 2006
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29. Estimation of Dietary Sources and Flavonoid Intake in a Spanish Adult Population (EPIC-Spain)
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Zamora-Ros, Raul, Andres-Lacueva, Cristina, Lamuela-Raventós, Rosa M., Berenguer, Toni, Jakszyn, Paula, Barricarte, Aurelio, Ardanaz, Eva, Amiano, Pilar, Dorronsoro, Miren, Larrañaga, Nerea, Martínez, Carmen, Sánchez, María J., Navarro, Carmen, Chirlaque, María D., Tormo, María J., Quirós, J. Ramón, and González, Carlos A.
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- 2010
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30. Soluble Receptor for Advanced Glycation End-products (sRAGE) and colorectal cancer risk: a 1 case-control study nested within a European prospective cohort
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Aglago, Elom K., Rinaldi, Sabina, Freisling, Heinz, Jiao, Li, Hughes, David J., Fedirko, Veronika, Schalkwijk, Casper C, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Eriksen, Anne Kirstine, Kyrø, Cecilie, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A., Severi, Gianluca, Katzke, Verena, Kuhn, Tilman, Schulze, Matthias B., Krasimira, Aleksandrova, Masala, Giovanna, Krogh, Vittorio, Panico, Salavatore, Tumino, Rosario, Naccarati, Alessio, Bueno-De-Mesquita, Bas, van Gils, Carla H., Sandanger, Torkjel M, Gram, Inger Torhild, Skeie, Guri, Quiros, J. Ramon, Jakszyn, Rachel, Sanchez, Maria-Jose, Amiano, Pilar, Huerta, Jose Maria, Ardanaz, Eva, Johansson, Ingegerd, Harlid, Sophia, Perez-Cornago, Aurora, Mayén, Ana-Lucia, Cordova, Reynalda, Gunter, Marc J., Vineis, Paolo, Cross, Amanda J., Riboli, Elio, and Jenab, Mazda
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VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 ,VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 - Abstract
Background: Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation. Methods: To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma sRAGE concentrations were measured by ELISA in 1,361 colorectal cancer matched case–control sets. Twenty-four SNPs encoded in the genes associated with sRAGE concentrations were available for 1,985 colorectal cancer cases and 2,220 controls. Multivariable adjusted ORs and 95% confidence intervals (CIs) were computed using conditional and unconditional logistic regression for colorectal cancer risk and circulating sRAGE and SNPs, respectively. Results: Higher sRAGE concentrations were inversely associated with colorectal cancer (ORQ5vs.Q1, 0.77; 95% CI, 0.59–1.00). Sex-specific analyses revealed that the observed inverse risk association was restricted to men (ORQ5vs.Q1, 0.63; 95% CI, 0.42–0.94), whereas no association was observed in women (ORQ5vs.Q1, 1.00; 95% CI, 0.68–1.48; Pheterogeneity for sex = 0.006). Participants carrying minor allele of rs653765 (promoter region of ADAM10) had lower colorectal cancer risk (C vs. T, OR, 0.90; 95% CI, 0.82–0.99). Conclusions: Prediagnostic sRAGE concentrations were inversely associated with colorectal cancer risk in men, but not in women. An SNP located within ADAM10 gene, pertaining to RAGE shedding, was associated with colorectal cancer risk. Impact: Further studies are needed to confirm our observed sex difference in the association and better explore the potential involvement of genetic variants of sRAGE in colorectal cancer development.
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- 2020
31. Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study
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Key, Timothy J, Appleby, Paul N, Allen, Naomi E, Travis, Ruth C, Roddam, Andrew W, Jenab, Mazda, Egevad, Lars, Tjønneland, Anne, Johnsen, Nina F, Overvad, Kim, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Pischon, Tobias, Psaltopoulou, Theodora, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Palli, Domenico, Vineis, Paolo, Tumino, Rosario, Berrino, Franco, Kiemeney, Lambertus, Bueno-de-Mesquita, H Bas, Quirós, J Ramón, González, Carlos A, Martinez, Carmen, Larrañaga, Nerea, Chirlaque, María Dolores, Ardanaz, Eva, Stattin, Pär, Hallmans, Göran, Khaw, Kay-Tee, Bingham, Sheila, Slimani, Nadia, Ferrari, Pietro, Rinaldi, Sabina, and Riboli, Elio
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- 2007
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32. Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity
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Hendricks, Audrey E., Bochukova, Elena G., Marenne, Gaëlle, Keogh, Julia M., Atanassova, Neli, Bounds, Rebecca, Wheeler, Eleanor, Mistry, Vanisha, Henning, Elana, Körner, Antje, Muddyman, Dawn, McCarthy, Shane, Hinney, Anke, Hebebrand, Johannes, Scott, Robert A., Langenberg, Claudia, Wareham, Nick J., Surendran, Praveen, Howson, Joanna M M, Butterworth, Adam S., Danesh, John, Nordestgaard, Børge G., Nielsen, Sune F., Afzal, Shoaib, Papadia, Sofia, Ashford, Sofie, Garg, Sumedha, Millhauser, Glenn L., Palomino, Rafael I., Kwasniewska, Alexandra, Tachmazidou, Ioanna, O'Rahilly, Stephen, Zeggini, Eleftheria, Barroso, Inês, Farooqi, I. Sadaf, Benzeval, Michaela, Burton, Jonathan, Buck, Nicholas, Jäckle, Annette, Kumari, Meena, Laurie, Heather, Lynn, Peter, Pudney, Stephen, Rabe, Birgitta, Wolke, Dieter, Overvad, Kim, Tjønneland, Anne, Clavel-Chapelon, Francoise, Kaaks, Rudolf, Boeing, Heiner, Trichopoulou, Antonia, Ferrari, Pietro, Palli, Domenico, Krogha, Vittorio, Panico, Salvatore, Tuminoa, Rosario, Matullo, Giuseppe, Boer, Jolanda Ma, Van Der Schouw, Yvonne, Weiderpass, Elisabete, Quiros, J. Ramon, Sánchez, María José, Navarro, Carmen, Moreno-Iribas, Conchi, Arriola, Larraitz, Melander, Olle, Wennberg, Patrik, Key, Timothy J., Riboli, Elio, Al-Turki, Saeed, Anderson, Carl A, Anney, Richard, Antony, Dinu, Soler Artigas, María, Ayub, Muhammad, Bala, Senduran, Barrett, Jeffrey C, Beales, Phil, Bentham, Jamie, Bhattacharyaa, Shoumo, Birney, Ewan, Blackwooda, Douglas, Bobrow, Martin, Bolton, Patrick F., Boustred, Chris, Breen, Gerome, Calissanoa, Mattia, Carss, Keren, Charlton, Ruth, Chatterjee, Krishna, Chen, Lu, Ciampia, Antonio, Cirak, Sebahattin, Clapham, Peter, Clement, Gail, Coates, Guy, Coccaa, Massimiliano, Collier, David A, Cosgrove, Catherine, Coxa, Tony, Craddock, Nick, Crooks, Lucy, Curran, Sarah, Curtis, David, Daly, Allan, Danecek, Petr, Day, Ian N M, Day-Williams, Aaron G, Dominiczak, Anna, Down, Thomas, Du, Yuanping, Dunham, Ian, Durbin, Richard, Edkins, Sarah, Ekong, Rosemary, Ellis, Peter, Evansa, David M., FitzPatrick, David R., Flicek, Paul, Floyd, James S., Foley, A. Reghan, Franklin, Christopher S., Futema, Marta, Gallagher, Louise, Gaunt, Tom R., Geihs, Matthias, Geschwind, Daniel H., Greenwood, Celia M.T., Griffin, Heather, Grozeva, Detelina, Guo, Xiaosen, Guo, Xueqin, Gurling, Hugh, Hart, Deborah J., Holmans, Peter A, Howie, Bryan, Huang, Jie, Huang, Liren, Hubbard, Tim, Humphries, Steve E., Hurles, Matthew E., Hysi, Pirro G., Iotchkova, Valentina, Jackson, David K., Jamshidi, Yalda, Joyce, Chris, Karczewski, Konrad J., Kaye, Jane, Keane, Thomas, Kemp, John P., Kennedy, Karen, Kent, Alastair, Khawaja, Farrah, Van Kogelenberg, Margriet, Kolb-Kokocinski, Anja, Lachance, Genevieve, Langford, Cordelia, Lawson, Daniel, Lee, Irene, Lek, Monkol, Li, Rui, Li, Yingrui, Liang, Jieqin, Lin, Hong, Liu, Ryan, Lönnqvist, Jouko, Lopes, Luis R., Lopes, Margarida, MacArthur, Daniel G., Mangino, Massimo, Marchini, Jonathan, Maslen, John, Mathieson, Iain, McGuffin, Peter, McIntosh, Andrew M., McKechanie, Andrew G., McQuillin, Andrew, Memari, Yasin, Metrustry, Sarah, Migone, Nicola, Min, Josine L., Mitchison, Hannah M, Moayyeri, Alireza, Morris, Andrew D., Morris, James, Muntoni, Francesco, Northstone, Kate, O'Donovan, Michael C., Onoufriadis, Alexandros, Oualkacha, Karim, Owen, Michael J, Palotie, Aarno, Panoutsopoulou, Kalliope, Parker, Victoria, Parr, Jeremy R., Paternoster, Lavinia, Paunio, Tiina, Payne, Felicity, Payne, Stewart J., Perry, John R. B., Pietilainen, Olli, Plagnol, Vincent, Pollitt, Rebecca C., Porteous, David J., Povey, Sue, Quail, Michael A., Quaye, Lydia, Raymond, F. Lucy, Rehnström, Karola, Richards, J Brent, Ridout, Cheryl K., Ring, Susan M., Ritchie, Graham R.S., Roberts, Nicola, Robinson, Rachel L., Savage, David B., Scambler, Peter, Schiffels, Stephan, Schmidts, Miriam, Schoenmakers, Nadia, Scott, Richard H., Semple, Robert K., Serra, Eva, Sharp, Sally I., Shaw, Adam, Shihab, Hashem A., Shin, So Youn, Skuse, David, Small, Kerrin S, Smee, Carol, Smith, Blair H., Davey Smith, George, Soranzo, Nicole, Southam, Lorraine, Spasic-Boskovic, Olivera, Spector, Timothy D, St Clair, David, St Pourcain, Beate, Stalker, Jim, Stevens, Elizabeth, Sun, Jianping, Surdulescu, Gabriela L, Suvisaari, Jaana, Syrris, Petros, Taylor, Rohan, Tian, Jing, Timpson, Nicholas J., Tobin, Martin D, Valdes, Ana M., Vandersteen, Anthony M., Vijayarangakannan, Parthiban, Visscher, Peter M., Wain, Louise V., Walter, Klaudia, Walters, James T.R., Wang, Guangbiao, Wang, Jun, Wang, Nai-Yu, Ward, Kirsten, Whyte, Tamieka, Williams, Hywel J., Williamson, Kathleen A., Wilson, Crispian, Wilson, Scott G., Wong, Kim, Xu, Changjiang, Yang, Jian, Zhang, Feng, Zhang, Pingbo, Zheng, Hou Feng, Hendricks, Audrey E., Bochukova, Elena G., Marenne, Gaã«lle, Keogh, Julia M., Atanassova, Neli, Bounds, Rebecca, Wheeler, Eleanor, Mistry, Vanisha, Henning, Elana, Kã¶rner, Antje, Muddyman, Dawn, Mccarthy, Shane, Hinney, Anke, Hebebrand, Johanne, Scott, Robert A., Langenberg, Claudia, Wareham, Nick J., Surendran, Praveen, Howson, Joanna M., Butterworth, Adam S., Danesh, John, Nordestgaard, Bã¸rge G, Nielsen, Sune F, Afzal, Shoaib, Papadia, Sofia, Ashford, Sofie, Garg, Sumedha, Millhauser, Glenn L., Palomino, Rafael I., Kwasniewska, Alexandra, Tachmazidou, Ioanna, O'Rahilly, Stephen, Zeggini, Eleftheria, Barroso, Inãª, Farooqi, I. Sadaf, Benzeval, Michaela, Burton, Jonathan, Buck, Nichola, Jã¤ckle, Annette, Kumari, Meena, Laurie, Heather, Lynn, Peter, Pudney, Stephen, Rabe, Birgitta, Wolke, Dieter, Overvad, Kim, Tjã¸nneland, Anne, Clavel chapelon, Francoise, Kaaks, Rudolf, Boeing, Heiner, Trichopoulou, Antonia, Ferrari, Pietro, Palli, Domenico, Krogha, Vittorio, Panico, Salvatore, Tuminoa, Rosario, Matullo, Giuseppe, Boer, Jolanda, Van Der Schouw, Yvonne, Weiderpass, Elisabete, Quiros, J. Ramon, Sã¡nchez, Marãa josã©, Navarro, Carmen, Moreno iribas, Conchi, Arriola, Larraitz, Melander, Olle, Wennberg, Patrik, Key, Timothy J., Riboli, Elio, Turki, Saeed Al, Anderson, Carl A., Anney, Richard, Antony, Dinu, Soler Artigas, Marãa, Ayub, Muhammad, Bala, Senduran, Barrett, Jeffrey C., Beales, Phil, Bentham, Jamie, Bhattacharyaa, Shoumo, Birney, Ewan, Blackwooda, Dougla, Bobrow, Martin, Bolton, Patrick F., Boustred, Chri, Breen, Gerome, Calissanoa, Mattia, Carss, Keren, Charlton, Ruth, Chatterjee, Krishna, Chen, Lu, Ciampia, Antonio, Cirak, Sebahattin, Clapham, Peter, Clement, Gail, Coates, Guy, Coccaa, Massimiliano, Collier, David A., Cosgrove, Catherine, Coxa, Tony, Craddock, Nick, Crooks, Lucy, Curran, Sarah, Curtis, David, Daly, Allan, Danecek, Petr, Day, Ian N. M., Day williams, Aaron, Dominiczak, Anna, Down, Thoma, Du, Yuanping, Dunham, Ian, Durbin, Richard, Edkins, Sarah, Ekong, Rosemary, Ellis, Peter, Evansa, David M., Fitzpatrick, David R., Flicek, Paul, Floyd, Jame, Foley, A. Reghan, Franklin, Christopher S., Futema, Marta, Gallagher, Louise, Gaunt, Tom R., Geihs, Matthia, Geschwind, Daniel, Greenwood, Celia M. T., Griffin, Heather, Grozeva, Detelina, Guo, Xiaosen, Guo, Xueqin, Gurling, Hugh, Hart, Deborah, Holmans, Peter, Howie, Bryan, Huang, Jie, Huang, Liren, Hubbard, Tim, Humphries, Steve E., Hurles, Matthew E., Hysi, Pirro, Iotchkova, Valentina, Jackson, David K., Jamshidi, Yalda, Joyce, Chri, Karczewski, Konrad J., Kaye, Jane, Keane, Thoma, Kemp, John P., Kennedy, Karen, Kent, Alastair, Khawaja, Farrah, Van Kogelenberg, Margriet, Kolb kokocinski, Anja, Lachance, Genevieve, Langford, Cordelia, Lawson, Daniel, Lee, Irene, Lek, Monkol, Li, Rui, Li, Yingrui, Liang, Jieqin, Lin, Hong, Liu, Ryan, Lã¶nnqvist, Jouko, Lopes, Luis R., Lopes, Margarida, Macarthur, Daniel G., Mangino, Massimo, Marchini, Jonathan, Maslen, John, Mathieson, Iain, Mcguffin, Peter, Mcintosh, Andrew M., Mckechanie, Andrew G., Mcquillin, Andrew, Memari, Yasin, Metrustry, Sarah, Migone, Nicola, Min, Josine L., Mitchison, Hannah M., Moayyeri, Alireza, Morris, Andrew, Morris, Jame, Muntoni, Francesco, Northstone, Kate, O'Donovan, Michael C., Onoufriadis, Alexandro, Oualkacha, Karim, Owen, Michael J., Palotie, Aarno, Panoutsopoulou, Kalliope, Parker, Victoria, Parr, Jeremy R., Paternoster, Lavinia, Paunio, Tiina, Payne, Felicity, Payne, Stewart J., Perry, John R. B., Pietilainen, Olli, Plagnol, Vincent, Pollitt, Rebecca C., Porteous, David J., Povey, Sue, Quail, Michael A., Quaye, Lydia, Raymond, F. Lucy, Rehnstrã¶m, Karola, Richards, J. Brent, Ridout, Cheryl K., Ring, Susan, Ritchie, Graham R. S., Roberts, Nicola, Robinson, Rachel L., Savage, David B., Scambler, Peter, Schiffels, Stephan, Schmidts, Miriam, Schoenmakers, Nadia, Scott, Richard H., Semple, Robert K., Serra, Eva, Sharp, Sally I., Shaw, Adam, Shihab, Hashem A., Shin, So youn, Skuse, David, Small, Kerrin S., Smee, Carol, Smith, Blair H., Davey Smith, George, Soranzo, Nicole, Southam, Lorraine, Spasic boskovic, Olivera, Spector, Timothy D., St Clair, David, St Pourcain, Beate, Stalker, Jim, Stevens, Elizabeth, Sun, Jianping, Surdulescu, Gabriela, Suvisaari, Jaana, Syrris, Petro, Taylor, Rohan, Tian, Jing, Timpson, Nicholas J., Tobin, Martin D., Valdes, Ana M., Vandersteen, Anthony M., Vijayarangakannan, Parthiban, Visscher, Peter M., Wain, Louise V., Walter, Klaudia, Walters, James T. R., Wang, Guangbiao, Wang, Jun, Wang, Yu, Ward, Kirsten, Whyte, Tamieka, Williams, Hywel J., Williamson, Kathleen A., Wilson, Crispian, Wilson, Scott G., Wong, Kim, Xu, Changjiang, Yang, Jian, Zhang, Feng, Zhang, Pingbo, and Zheng, Hou feng
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Multidisciplinary ,Journal Article ,General - Abstract
Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants contributing to obesity in 2% of cases including multiple novel variants in GNAS, which were sometimes found with accelerated growth rather than short stature as describedw previously. Nominally significant associations were found for rare functional variants in BBS1, BBS9, GNAS, MKKS, CLOCK and ANGPTL6. The p.S284X variant in ANGPTL6 drives the association signal (rs201622589, MAF∼0.1%, odds ratio = 10.13, p-value = 0.042) and results in complete loss of secretion in cells. Further analysis including additional case-control studies and population controls (N = 260,642) did not support association of this variant with obesity (odds ratio = 2.34, p-value = 2.59 × 10-3), highlighting the challenges of testing rare variant associations and the need for very large sample sizes. Further validation in cohorts with severe obesity and engineering the variants in model organisms will be needed to explore whether human variants in ANGPTL6 and other genes that lead to obesity when deleted in mice, do contribute to obesity. Such studies may yield druggable targets for weight loss therapies.
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- 2017
33. Body size and risk of colon and rectal cancer in the European prospective investigation into cancer and nutrition (EPIC)
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Pischon, Tobias, Lahmann, Petra H., Boeing, Heiner, Friedenreich, Christine, Norat, Teresa, Tjonneland, Anne, Halkjaer, Jytte, Overvad, Kim, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Guernec, Gregory, Bergmann, Manuela M., Linseisen, Jakob, Becker, Nikolaus, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Sieri, Sabina, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Boshuizen, Hendriek C., Van Guelpen, Bethany, Palmqvist, Richard, Berglund, Goran, Gonzalez, Carlos Alberto, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Martinez, Carmen, Quiros, J. Ramon, Roddam, Andrew, Allen, Naomi, Bingham, Sheila, Khaw, Kay-Tee, Ferrari, Pietro, Kaaks, Rudolf, Slimani, Nadia, and Riboli, Elio
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Colon cancer -- Causes of ,Colon cancer -- Case studies ,Colorectal cancer -- Causes of ,Colorectal cancer -- Case studies ,Obesity -- Complications and side effects ,Obesity -- Case studies ,Health - Abstract
Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the association between anthropometric measures and risks of colon and rectal cancer among 368 277 men and women who were free of cancer at baseline from nine countries of the European Prospective Investigation Into Cancer and Nutrition. All statistical tests were two-sided. Results: During 6.1 years of follow-up, we identified 984 and 586 patients with colon and rectal cancer, respectively. Body weight and BMI were statistically significantly associated with colon cancer risk in men (highest versus lowest quintile of BMI, relative risk [RR] = 1.55, 95% confidence interval [CI] = 1.12 to 2.15; [P.sub.trend] = .006) but not in women. In contrast, comparisons of the highest to the lowest quintile showed that several anthropometric measures, including waist circumference (men, RR = 1.39, 95% CI = 1.01 to 1.93; [P.sub.trend] = .001; women, RR = 1.48, 95% CI = 1.08 to 2.03; [P.sub.trend] = .008), waist-to-hip ratio (WHR; men, RR = 1.51, 95% CI = 1.06 to 2.15; [P.sub.trend] = .006; women, RR = 1.52, 95% CI = 1.12 to 2.05; [P.sub.trend] = .002), and height (men, RR = 1.40, 95% CI = 0.99 to 1.98; [P.sub.trend] = .04; women, RR = 1.79, 95% CI = 1.30 to 2.46; [P.sub.trend]
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- 2006
34. Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Kaaks, Rudolf, Berrino, Franco, Key, Timothy, Rinaldi, Sabina, Dossus, Laure, Biessy, Carine, Secreto, Giorgio, Amiano, Pilar, Bingham, Sheila, Boeing, Heiner, de Mesquita, H. Bas Bueno, Chang-Claude, Jenny, Clavel-Chapelon, Francoise, Fournier, Agnes, van Gils, Carla H., Gonzalez, Carlos A., Gurrea, Aurelio Barricarte, Critselis, Elena, Khaw, Kay Tee, Krogh, Vittorio, Lahmann, Petra H., Nagel, Gabriele, Olsen, Anja, Onland-Moret, N. Charlotte, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Peeters, Petra, Quiros, J. Ramon, Roddam, Andrew, Thiebaut, Anne, Tjonneland, Anne, Chirlaque, Ma Dolores, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Tumino, Rosario, Vineis, Paolo, Norat, Teresa, Ferrari, Pietro, Slimani, Nadia, and Riboli, Elio
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Breast cancer -- Risk factors ,Women -- Health aspects ,Health - Abstract
Background: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, estrogen and progesterone excess, and both an excess or lack of adrenal androgens (dehydroepiandrosterone [DHEA] or its sulfate [DHEASI) as risk factors. We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort to examine associations among premenopausal serum concentrations of sex steroids and subsequent breast cancer risk. Methods: Levels of DHEAS, (A4-)androstenedione, testosterone, and sex hormone binding globulin (SHBG) were measured in single prediagnostic serum samples from 370 premenopausal women who subsequently developed breast cancer (case patients) and from 726 matched cancer-free control subjects. Levels of progesterone, estrone, and estradiol were also measured for the 285 case patients and 555 matched control subjects who had provided information about the day of menstrual cycle at blood donation. Conditional logistic regression models were used to estimate relative risks of breast cancer by quartiles of hormone concentrations. All statistical tests were two-sided. Results: Increased risks of breast cancer were associated with elevated serum concentrations of testosterone (odds ratio [OR] for highest versus lowest quartile = 1.73, 95% confidence interval [CI] = 1.16 to 2.57; [P.sub.trend] = .01), androstenedione (OR for highest versus lowest quartile = 1.56, 95% CI = 1.05 to 2.32; [P.sub.trend] : .01), and DHEAS (OR for highest versus lowest quartile = 1.48, 95% CI = 1.02 to 2.14; [P.sub.trend] = .10) but not SHBG. Elevated serum progesterone concentrations were associated with a statistically significant reduction in breast cancer risk (OR for highest versus lowest quartile = 0.61, 95% CI = 0.38 to 0.98; [P.sub.trend] = .06). The absolute risk of breast cancer for women younger than 40 followed up for 10 years was estimated at 2.6% for those in the highest quartile of serum testosterone versus 1.5% for those in the lowest quartile; for the highest and lowest quartiles of progesterone, these estimates were 1.7% and 2.6%, respectively. Breast cancer risk was not statistically significantly associated with serum levels of the other hormones. Conclusions: Our results support the hypothesis that elevated blood concentrations of androgens are associated with an increased risk of breast cancer in premenopausal women.
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- 2005
35. Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
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Wood, Angela M, primary, Kaptoge, Stephen, additional, Butterworth, Adam S, additional, Willeit, Peter, additional, Warnakula, Samantha, additional, Bolton, Thomas, additional, Paige, Ellie, additional, Paul, Dirk S, additional, Sweeting, Michael, additional, Burgess, Stephen, additional, Bell, Steven, additional, Astle, William, additional, Stevens, David, additional, Koulman, Albert, additional, Selmer, Randi M, additional, Verschuren, W M Monique, additional, Sato, Shinichi, additional, Njølstad, Inger, additional, Woodward, Mark, additional, Salomaa, Veikko, additional, Nordestgaard, Børge G, additional, Yeap, Bu B, additional, Fletcher, Astrid, additional, Melander, Olle, additional, Kuller, Lewis H, additional, Balkau, Beverley, additional, Marmot, Michael, additional, Koenig, Wolfgang, additional, Casiglia, Edoardo, additional, Cooper, Cyrus, additional, Arndt, Volker, additional, Franco, Oscar H, additional, Wennberg, Patrik, additional, Gallacher, John, additional, de la Cámara, Agustín Gómez, additional, Völzke, Henry, additional, Dahm, Christina C, additional, Dale, Caroline E, additional, Bergmann, Manuela M, additional, Crespo, Carlos J, additional, van der Schouw, Yvonne T, additional, Kaaks, Rudolf, additional, Simons, Leon A, additional, Lagiou, Pagona, additional, Schoufour, Josje D, additional, Boer, Jolanda M A, additional, Key, Timothy J, additional, Rodriguez, Beatriz, additional, Moreno-Iribas, Conchi, additional, Davidson, Karina W, additional, Taylor, James O, additional, Sacerdote, Carlotta, additional, Wallace, Robert B, additional, Quiros, J Ramon, additional, Tumino, Rosario, additional, Blazer, Dan G, additional, Linneberg, Allan, additional, Daimon, Makoto, additional, Panico, Salvatore, additional, Howard, Barbara, additional, Skeie, Guri, additional, Strandberg, Timo, additional, Weiderpass, Elisabete, additional, Nietert, Paul J, additional, Psaty, Bruce M, additional, Kromhout, Daan, additional, Salamanca-Fernandez, Elena, additional, Kiechl, Stefan, additional, Krumholz, Harlan M, additional, Grioni, Sara, additional, Palli, Domenico, additional, Huerta, José M, additional, Price, Jackie, additional, Sundström, Johan, additional, Arriola, Larraitz, additional, Arima, Hisatomi, additional, Travis, Ruth C, additional, Panagiotakos, Demosthenes B, additional, Karakatsani, Anna, additional, Trichopoulou, Antonia, additional, Kühn, Tilman, additional, Grobbee, Diederick E, additional, Barrett-Connor, Elizabeth, additional, van Schoor, Natasja, additional, Boeing, Heiner, additional, Overvad, Kim, additional, Kauhanen, Jussi, additional, Wareham, Nick, additional, Langenberg, Claudia, additional, Forouhi, Nita, additional, Wennberg, Maria, additional, Després, Jean-Pierre, additional, Cushman, Mary, additional, Cooper, Jackie A, additional, Rodriguez, Carlos J, additional, Sakurai, Masaru, additional, Shaw, Jonathan E, additional, Knuiman, Matthew, additional, Voortman, Trudy, additional, Meisinger, Christa, additional, Tjønneland, Anne, additional, Brenner, Hermann, additional, Palmieri, Luigi, additional, Dallongeville, Jean, additional, Brunner, Eric J, additional, Assmann, Gerd, additional, Trevisan, Maurizio, additional, Gillum, Richard F, additional, Ford, Ian, additional, Sattar, Naveed, additional, Lazo, Mariana, additional, Thompson, Simon G, additional, Ferrari, Pietro, additional, Leon, David A, additional, Smith, George Davey, additional, Peto, Richard, additional, Jackson, Rod, additional, Banks, Emily, additional, Di Angelantonio, Emanuele, additional, Danesh, John, additional, Wood, Angela M, additional, Butterworth, Adam, additional, Verschuren, Monique, additional, Veikko, Salomaa, additional, Flecther, Astrid, additional, Gómez de la Cámara, Agustín, additional, Bergmann, Manuela, additional, Crespo, Carlos, additional, Boer, Jolanda M.A, additional, Quiros, J. Ramon, additional, Rimm, Eric B, additional, Blazer III, Dan G, additional, Dallongeville, Jean-Pierre, additional, Gillumn, Richard F, additional, Ford, Ian Ford, additional, Thompson, Simon, additional, and Davey Smith, George, additional
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- 2018
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36. Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study
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Ricci, Cristian Wood, Angela Muller, David Gunter, Marc J. and Agudo, Antonio Boeing, Heiner van der Schouw, Yvonne T. and Warnakula, Samantha Saieva, Calogero Spijkerman, Annemieke and Sluijs, Ivonne Tjonneland, Anne Kyro, Cecilie Weiderpass, Elisabete Kuehn, Tilman Kaaks, Rudolf Sanchez, Maria-Jose and Panico, Salvatore Agnoli, Claudia Palli, Domenico and Tumino, Rosario Engstrom, Gunnar Melander, Olle Bonnet, Fabrice Boer, Jolanda M. A. Key, Timothy J. Travis, Ruth C. and Overvad, Kim Verschuren, W. M. Monique Quiros, J. Ramon and Trichopoulou, Antonia Papatesta, Eleni-Maria Peppa, Eleni and Iribas, Conchi Moreno Gavrila, Diana Forslund, Ann-Sofie and Jansson, Jan-Hakan Matullo, Giuseppe Arriola, Larraitz and Freisling, Heinz Lassale, Camille Tzoulaki, Ioanna Sharp, Stephen J. Forouhi, Nita G. Langenberg, Claudia Saracci, Rodolfo Sweeting, Michael Brennan, Paul Butterworth, Adam S. and Riboli, Elio Wareham, Nick J. Danesh, John Ferrari, Pietro
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cardiovascular diseases - Abstract
OBJECTIVE To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke. DESIGN Multicentre case-cohort study. SETTING A study of cardiovascular disease (CVD) determinants within the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European countries. PARTICIPANTS 32 549 participants without baseline CVD, comprised of incident CVD cases and a subcohort for comparison. MAIN OUTCOME MEASURES Non-fatal and fatal CHD and stroke (including ischaemic and haemorrhagic stroke). RESULTS There were 9307 non-fatal CHD events, 1699 fatal CHD, 5855 non-fatal stroke, and 733 fatal stroke. Baseline alcohol intake was inversely associated with non-fatal CHD, with a hazard ratio of 0.94 (95% confidence interval 0.92 to 0.96) per 12 g/day higher intake. There was a J shaped association between baseline alcohol intake and risk of fatal CHD. The hazard ratios were 0.83 (0.70 to 0.98), 0.65 (0.53 to 0.81), and 0.82 (0.65 to 1.03) for categories 5.0-14.9 g/day, 15.0-29.9 g/day, and 30.0-59.9 g/day of total alcohol intake, respectively, compared with 0.1-4.9 g/ day. In contrast, hazard ratios for non-fatal and fatal stroke risk were 1.04 (1.02 to 1.07), and 1.05 (0.98 to 1.13) per 12 g/day increase in baseline alcohol intake, respectively, including broadly similar findings for ischaemic and haemorrhagic stroke. Associations with cardiovascular outcomes were broadly similar with average lifetime alcohol consumption as for baseline alcohol intake, and across the eight countries studied. There was no strong evidence for interactions of alcohol consumption with smoking status on the risk of CVD events. CONCLUSIONS Alcohol intake was inversely associated with non-fatal CHD risk but positively associated with the risk of different stroke subtypes. This highlights the opposing associations of alcohol intake with different CVD types and strengthens the evidence for policies to reduce alcohol consumption.
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- 2018
37. Low Free Testosterone and Prostate Cancer Risk : A Collaborative Analysis of 20 Prospective Studies
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Watts, Eleanor L., Appleby, Paul N., Perez-Cornago, Aurora, Bueno-de-Mesquita, H. Bas, Chan, June M., Chen, Chu, Cohn, Barbara A., Cook, Michael B., Flicker, Leon, Freedman, Neal D., Giles, Graham G., Giovannucci, Edward, Gislefoss, Randi E., Hankey, Graeme J., Kaaks, Rudolf, Knekt, Paul, Kolonel, Laurence N., Kubo, Tatsuhiko, Le Marchand, Loic, Luben, Robert N., Luostarinen, Tapio, Mannisto, Satu, Metter, E. Jeffrey, Mikami, Kazuya, Milne, Roger L., Ozasa, Kotaro, Platz, Elizabeth A., Quiros, J. Ramon, Rissanen, Harri, Sawada, Norie, Stampfer, Meir, Stanczyk, Frank Z., Stattin, Pär, Tamakoshi, Akiko, Tangen, Catherine M., Thompson, Ian M., Tsilidis, Konstantinos K., Tsugane, Shoichiro, Ursin, Giske, Vatten, Lars, Weiss, Noel S., Yeap, Bu B., Allen, Naomi E., Key, Timothy J., and Travis, Ruth C.
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Adult ,Male ,Urologic Diseases ,Aging ,Time Factors ,Epidemiology ,Clinical Sciences ,FLOATING ABSOLUTE RISK ,Down-Regulation ,Risk Assessment ,Pooled analysis ,SEX STEROID ASSAYS ,Risk Factors ,Clinical Research ,Urologi och njurmedicin ,Humans ,2.1 Biological and endogenous factors ,Urology and Nephrology ,Sex hormones ,Testosterone ,Prospective Studies ,Aetiology ,Aged ,Cancer ,PREVENTION TRIAL ,Science & Technology ,Prostate cancer ,Prevention ,ANDROGEN RECEPTOR ,Prostatic Neoplasms ,MEN ,1103 Clinical Sciences ,MASS-SPECTROMETRY ,Androgens Pooled analysis ,Middle Aged ,Protective Factors ,Urology & Nephrology ,SERUM TESTOSTERONE ,Case-Control Studies ,Androgens ,FINASTERIDE ,CLINICAL-IMPLICATIONS ,HORMONES ,Neoplasm Grading ,Life Sciences & Biomedicine ,Prospective studies ,Biomarkers - Abstract
Background Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting. Objective To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer. Design, setting, and participants Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. Outcome measurements and statistical analysis Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration. Results and limitations Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR = 0.77, 95% confidence interval [CI] 0.69–0.86; p < 0.001) compared with men with higher concentrations (2nd–10th tenths of the distribution). Heterogeneity was present by tumour grade (phet = 0.01), with a lower risk of low-grade disease (OR = 0.76, 95% CI 0.67–0.88) and a nonsignificantly higher risk of high-grade disease (OR = 1.56, 95% CI 0.95–2.57). There was no evidence of heterogeneity by tumour stage. The observational design is a limitation. Conclusions Men with low circulating free testosterone may have a lower risk of overall prostate cancer; this may be due to a direct biological effect, or detection bias. Further research is needed to explore the apparent differential association by tumour grade. Patient summary In this study, we looked at circulating testosterone levels and risk of developing prostate cancer, finding that men with low testosterone had a lower risk of prostate cancer. © 2018 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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- 2018
38. Association of menopausal characteristics and risk of coronary heart disease: a pan-European case–cohort analysis
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Dam, Veerle, primary, van der Schouw, Yvonne T, additional, Onland-Moret, N Charlotte, additional, Groenwold, Rolf H H, additional, Peters, Sanne A E, additional, Burgess, Stephen, additional, Wood, Angela M, additional, Chirlaque, Maria-Dolores, additional, Moons, Karel G M, additional, Oliver-Williams, Clare, additional, Schuit, Ewoud, additional, Tikk, Kaja, additional, Weiderpass, Elisabete, additional, Holm, Marianne, additional, Tjønneland, Anne, additional, Kühn, Tilman, additional, Fortner, Renée T, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, La Vecchia, Carlo, additional, Ferrari, Pietro, additional, Gunter, Marc, additional, Masala, Giovanna, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Boer, Jolanda M A, additional, Verschuren, W M Monique, additional, Salamanca-Fernández, Elena, additional, Arriola, Larraitz, additional, Moreno-Iribas, Conchi, additional, Engström, Gunnar, additional, Melander, Olle, additional, Nordendahl, Maria, additional, Wennberg, Patrik, additional, Key, Timothy J, additional, Colorado-Yohar, Sandra, additional, Matullo, Giuseppe, additional, Overvad, Kim, additional, Clavel-Chapelon, Francoise, additional, Boeing, Heiner, additional, Quiros, J Ramon, additional, di Angelantonio, Emanuele, additional, Langenberg, Claudia, additional, Sweeting, Michael J, additional, Riboli, Elio, additional, Wareham, Nicholas J, additional, Danesh, John, additional, and Butterworth, Adam, additional
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- 2019
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39. Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study
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Martinez Carmen, Agudo Antonio, Lund E Eiliv, Peeters Petra H, Bueno-De-Mesquita H Bas, Panico Salvatore, Tumino Rosario, Krogh Vittorio, Palli Domenico, Trichopoulou Antonia, Boeing Heiner, Linseisen Jacob, Clavel-Chapelon Francoise, Raaschou-Nielsen Ole, Overvad Kim, Airoldi Luisa, Veglia Fabrizio, Vigna-Taglianti Federica, Krzyzanowski Michal, Hoek Gerard, Vineis Paolo, Dorronsoro Miren, Barricarte Aurelio, Cirera Lluis, Quiros J Ramon, Berglund Goran, Manjer Jonas, Forsberg Bertil, Day Nicholas E, Key Tim J, Kaaks Rudolf, Saracci Rodolfo, and Riboli Elio
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Industrial medicine. Industrial hygiene ,RC963-969 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Several countries are discussing new legislation on the ban of smoking in public places, and on the acceptable levels of traffic-related air pollutants. It is therefore useful to estimate the burden of disease associated with indoor and outdoor air pollution. Methods We have estimated exposure to Environmental Tobacco Smoke (ETS) and to air pollution in never smokers and ex-smokers in a large prospective study in 10 European countries (European Prospective Investigation into Cancer and Nutrition)(N = 520,000). We report estimates of the proportion of lung cancers attributable to ETS and air pollution in this population. Results The proportion of lung cancers in never- and ex-smokers attributable to ETS was estimated as between 16 and 24%, mainly due to the contribution of work-related exposure. We have also estimated that 5–7% of lung cancers in European never smokers and ex-smokers are attributable to high levels of air pollution, as expressed by NO2 or proximity to heavy traffic roads. NO2 is the expression of a mixture of combustion (traffic-related) particles and gases, and is also related to power plants and waste incinerator emissions. Discussion We have estimated risks of lung cancer attributable to ETS and traffic-related air pollution in a large prospective study in Europe. Information bias can be ruled out due to the prospective design, and we have thoroughly controlled for potential confounders, including restriction to never smokers and long-term ex-smokers. Concerning traffic-related air pollution, the thresholds for indicators of exposure we have used are rather strict, i.e. they correspond to the high levels of exposure that characterize mainly Southern European countries (levels of NO2 in Denmark and Sweden are closer to 10–20 ug/m3, whereas levels in Italy are around 30 or 40, or higher). Therefore, further reduction in exposure levels below 30 ug/m3 would correspond to additional lung cancer cases prevented, and our estimate of 5–7% is likely to be an underestimate. Overall, our prospective study draws attention to the need for strict legislation concerning the quality of air in Europe.
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- 2007
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40. Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort
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Obon-Santacana, Mireia Lujan-Barroso, Leila Freisling, Heinz and Cadeau, Claire Fagherazzi, Guy Boutron-Ruault, Marie-Christine and Kaaks, Rudolf Fortner, Renee T. Boeing, Heiner Quiros, J. Ramon Molina-Montes, Esther Chamosa, Saioa Castano, Jose Maria Huerta Ardanaz, Eva Khaw, Kay-Tee Wareham, Nick and Key, Tim Trichopoulou, Antonia Lagiou, Pagona Naska, Androniki Palli, Domenico Grioni, Sara Tumino, Rosario and Vineis, Paolo De Magistris, Maria Santucci Bueno-de-Mesquita, H. B. Peeters, Petra H. Wennberg, Maria Bergdahl, Ingvar A. and Vesper, Hubert Riboli, Elio Duell, Eric J.
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Purpose Acrylamide was classified as ‘probably carcinogenic’ to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide ( HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log2) to improve normality. Median (25th-75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively. Results The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively. Conclusions Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in nonsmoking postmenopausal women from the EPIC cohort.
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- 2017
41. Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort
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Carayol, Marion Leitzmann, Michael F. Ferrari, Pietro and Zamora-Ros, Raul Achaintre, David Stepien, Magdalena and Schmidt, Julie A. Travis, Ruth C. Overvad, Kim Tjonneland, Anne Hansen, Louise Kaaks, Rudolf Kuehn, Tilman Boein, Heiner Bachlechner, Ursula Trichoroulou, Antonia Bamia, Christina Palli, Domenico Agnoli, Claudia Tumino, Rosario and Vineis, Paolo Panico, Salvatore Quiros, J. Ramon and Sanchez-Cantalejo, Emilio Huerta, Jose Maria Ardanaz, Eva and Arriola, Larraitz Agudo, Antonio Nilsson, Jan Melander, E. and Bueno-de-Mesquita, Bas Peeters, Petra H. Wareham, Nick and Khaw, Kay-Tee Jenab, Mazda Key, Timothy J. Scalbert, Augustin Rinaldi, Sabina
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Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.
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- 2017
42. Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study
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Fedirko, Veronika Hao Quang Tran Gewirtz, Andrew T. Stepien, Magdalena Trichopoulou, Antonia Aleksandrova, Krasimira and Olsen, Anja Tjonneland, Anne Overvad, Kim Carbonnel, Franck and Boutron-Ruault, Marie-Christine Severi, Gianluca Kuhn, Tilman Kaaks, Rudolf Boeing, Heiner Bamia, Christina and Lagiou, Pagona Grioni, Sara Panico, Salvatore Palli, Domenico Tumino, Rosario Naccarati, Alessio Peeters, Petra H. Bueno-de-Mesquita, H. B. Weiderpass, Elisabete Castano, Jose Maria Huerta Barricarte, Aurelio Sanchez, Maria-Jose and Dorronsoro, Miren Quiros, J. Ramon Agudo, Antonio Sjoberg, Klas Ohlsson, Bodil Hemmingsson, Oskar Werner, Marten and Bradbury, Kathryn E. Khaw, Kay-Tee Wareham, Nick Tsilidis, Konstantinos K. Aune, Dagfinn Scalbert, Augustin Romieu, Isabelle Riboli, Elio Jenab, Mazda
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Background: Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking. Methods: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. A total of 139 men and women diagnosed with hepatocellular carcinoma between 1992 and 2010 were matched to 139 control subjects. Multivariable rate ratios (RRs), including adjustment for potential confounders, hepatitis B/C positivity, and degree of liver dysfunction, were calculated with conditional logistic regression. Results: Antibody response to LPS and flagellin was associated with a statistically significant increase in the risk of hepatocellular carcinoma (highest vs. lowest quartile: RR = 11.76, 95% confidence interval = 1.70-81.40; P-trend = 0.021). This finding did not vary substantially by time from enrollment to diagnosis, and did not change after adjustment for chronic infection with hepatitis B and C viruses. Conclusions: These novel findings, based on exposures up to several years prior to diagnosis, support a role for gut-derived bacterial products in hepatocellular carcinoma development. Further study into the role of gut barrier failure and exposure to bacterial products in liver diseases is warranted.
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- 2017
43. Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
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Perez-Cornago, Aurora Appleby, Paul N. Tipper, Sarah Key, Timothy J. Allen, Naomi E. Nieters, Alexandra Vermeulen, Roel Roulland, Sandrine Casabonne, Delphine Kaaks, Rudolf and Fortner, Renee T. Boeing, Heiner Trichopoulou, Antonia and La Vecchia, Carlo Klinaki, Eleni Hansen, Louise Tjonneland, Anne Bonnet, Fabrice Fagherazzi, Guy Boutron-Ruault, Marie-Christine Pala, Valeria Masala, Giovanna Sacerdote, Carlotta Peeters, Petra H. Bueno-de-Mesquita, H. B(as) and Weiderpass, Elisabete Dorronsoro, Miren Quiros, J. Ramon and Barricarte, Aurelio Gavrila, Diana Agudo, Antonio Borgquist, Signe Rosendahl, Ann H. Melin, Beatrice Wareham, Nick and Khaw, Kay-Tee Gunter, Marc Riboli, Elio Vineis, Paolo and Travis, Ruth C.
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Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57-1.03], p(trend) = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all >= 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further What’s new? Insulin-like growth factor I does not appear to influence lymphoma risk, according to new results. IGF-I can promote some cancers, but there hasn’t been a prospective epidemiological study examining the link between IGF-I concentration and lymphoma risk. To uncover a link, these authors arranged a NESTED case-control study with participants from the European Prospective Investigation into Cancer and Nutrition (EPIC). They tested for IGF-I in pre-diagnosis samples and found no association between the factor and overall lymphoma risk, nor with any subtype, although the number of cases was small for each subtype, and further studies are necessary.
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- 2017
44. Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort
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Fortner, Renee T. Sarink, Danja Schock, Helena Johnson, Theron Tjonneland, Anne Olsen, Anja Overvad, Kim Affret, Aurelie His, Mathilde Boutron-Ruault, Marie-Christine and Boeing, Heiner Trichopoulou, Antonia Naska, Androniki and Orfanos, Philippos Palli, Domenico Sieri, Sabina Mattiello, Amalia Tumino, Rosario Ricceri, Fulvio Bueno-de-Mesquita, H. Bas Peeters, Petra H. M. Van Gils, Carla H. Weiderpass, Elisabete Lund, Eiliv Quiros, J. Ramon Agudo, Antonio and Sanchez, Maria-Jose Chirlaque, Maria-Dolores Ardanaz, Eva and Dorronsoro, Miren Key, Tim Khaw, Kay-Tee Rinaldi, Sabina and Dossus, Laure Gunter, Marc Merritt, Melissa A. Riboli, Elio and Kaaks, Rudolf
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musculoskeletal diseases - Abstract
Background: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. Methods: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER-, n = 386), matched 1: 1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: The associations between OPG and ER+ and ER-breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER-breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24-3.02]; p(trend) = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER-disease did not differ by menopausal status at blood collection (p(het) = 0.97), and we observed no heterogeneity by HT use at blood collection (p(het) >= 0.43) or age at breast cancer diagnosis (p(het) >= 0.30). Conclusions: This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER-breast cancer.
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- 2017
45. DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
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Ambatipudi, Srikant Horvath, Steve Perrier, Flavie Cuenin, Cyrille Hernandez-Vargas, Hector Le Calvez-Kelm, Florence and Durand, Geoffroy Byrnes, Graham Ferrari, Pietro Bouaoun, Liacine Sklias, Athena Chajes, Veronique Overvad, Kim and Seven, Gianluca Baglietto, Laura Clavel-Chapelon, Francoise and Kaaks, Rudolf Barrdahl, Myrto Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Naska, Androniki Masala, Giovanna and Agnoli, Claudia Polidoro, Silvia Tumino, Rosario Panico, Salvatore Dolle, Martijn Peeters, Petra H. M. Onland-Moret, N. Charlotte Sandanger, Torkjel M. Nost, Therese H. and Weiderpass, Elisabete Quiros, J. Ramon Agudo, Antonio and Rodriguez-Barranco, Miguel Castano, Jose Maria Huerta and Barricarte, Aurelio Fernandez, Ander Matheu Travis, Ruth C. and Vineis, Paolo Muller, David C. Riboli, Elio Gunter, Marc and Romieu, Isabelle Herceg, Zdenko
- Abstract
Aim of the study: A vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing, known as ‘epigenetic clock’, has been linked with cancer risk factors. This study aimed to evaluate whether the epigenetic clock is associated with breast cancer risk susceptibility and to identify potential epigenetics-based biomarkers for risk stratification. Methods: Here, we profiled DNA methylation changes in a nested case control study embedded in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (n = 960) using the Illumina HumanMethylation 450K BeadChip arrays and used the Horvath age estimation method to calculate epigenetic age for these samples. Intrinsic epigenetic age acceleration (IEAA) was estimated as the residuals by regressing epigenetic age on chronological age. Results: We observed an association between IEAA and breast cancer risk (OR, 1.04; 95% CI, 1.007-1.076, P = 0.016). One unit increase in IEAA was associated with a 4% increased odds of developing breast cancer (OR, 1.04; 95% CI, 1.007-1.076). Stratified analysis based on menopausal status revealed that IEAA was associated with development of postmenopausal breast cancers (OR, 1.07; 95% CI, 1.020-1.11, P = 0.003). In addition, methylome-wide analyses revealed that a higher mean DNA methylation at cytosine-phosphate-guanine (CpG) islands was associated with increased risk of breast cancer development (OR per 1 SD = 1.20; 95 %CI: 1.03-1.40, P = 0.02) whereas mean methylation levels at non-island CpGs were indistinguishable between cancer cases and controls. Conclusion: Epigenetic age acceleration and CpG island methylation have a weak, but statistically significant, association with breast cancer susceptibility. (C) 2017 Elsevier Ltd. All rights reserved.
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- 2017
46. Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
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Perez-Cornago, Aurora, Appleby, Paul N., Tipper, Sarah, Key, Timothy J., Allen, Naomi E., Nieters, Alexandra, Vermeulen, Roel, Roulland, Sandrine, Casabonne, Delphine, Kaaks, Rudolf, Fortner, Renee T., Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Klinaki, Eleni, Hansen, Louise, Tjonneland, Anne, Bonnet, Fabrice, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Pala, Valeria, Masala, Giovanna, Sacerdote, Carlotta, Peeters, Petra H., Bueno-De-Mesquita, H. B., Elisabete Weiderpass, Dorronsoro, Miren, Quiros, J. Ramon, Barricarte, Aurelio, Gavrila, Diana, Agudo, Antonio, Borgquist, Signe, Rosendahl, Ann H., Melin, Beatrice, Wareham, Nick, Khaw, Kay-Tee, Gunter, Marc, Riboli, Elio, Vineis, Paolo, Travis, Ruth C., University of Oxford [Oxford], Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), CIBER de Epidemiología y Salud Pública (CIBERESP), Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Gustave Roussy (IGR), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet [Stockholm], Genetic Epidemiology Group [Helsinki], Folkhälsan Research Center, Faculty of Medecine [Helsinki], University of Helsinki-University of Helsinki-Faculty of Medecine [Helsinki], University of Helsinki-University of Helsinki, Umeå University, University of Cambridge [UK] (CAM), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, University Medical Center Utrecht, Imperial College Trust, Wareham, Nicholas [0000-0003-1422-2993], Khaw, Kay-Tee [0000-0002-8802-2903], Apollo - University of Cambridge Repository, University of Oxford, Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Faculty of Medecine [Helsinki], and Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki
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Adult ,Male ,Risk ,Cancer Research ,Lymphoma ,EPIC cohort ,Short Report ,lymphoma ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Plasma ,Risk Factors ,hemic and lymphatic diseases ,Odds Ratio ,Journal Article ,Humans ,Oncology & Carcinogenesis ,Insulin-Like Growth Factor I ,non‐Hodgkin lymphoma ,plasma ,Non-Hodgkin lymphoma ,Aged ,IGF‐I ,Medicine(all) ,Aged, 80 and over ,Cancer och onkologi ,VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 ,nested case-control ,non-Hodgkin lymphoma ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,Middle Aged ,prospective ,Nutrition Surveys ,IGF-I ,VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 ,Europe ,Multicenter Study ,Prospective ,Oncology ,Socioeconomic Factors ,Cancer and Oncology ,Case-Control Studies ,Nested case-control ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,nested case–control ,1112 Oncology And Carcinogenesis ,Cancer Epidemiology ,Follow-Up Studies - Abstract
Insulin‐like growth factor (IGF)‐I has cancer promoting activities. However, the hypothesis that circulating IGF‐I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF‐I concentration was measured in pre‐diagnostic plasma samples from a nested case–control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF‐I concentration was not associated with overall lymphoma risk (multivariable‐adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57–1.03], p trend = 0.06). There was no statistical evidence of heterogeneity in this association with IGF‐I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (p heterogeneity for all ≥ 0.05). There were no associations between IGF‐I concentration and risk for specific BCL subtypes, T‐cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF‐I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF‐I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF‐I concentrations with lymphoma subtypes., What's new? Insulin‐like growth factor I does not appear to influence lymphoma risk, according to new results. IGF‐I can promote some cancers, but there hasn't been a prospective epidemiological study examining the link between IGF‐I concentration and lymphoma risk. To uncover a link, these authors arranged a NESTED case–control study with participants from the European Prospective Investigation into Cancer and Nutrition (EPIC). They tested for IGF‐I in pre‐diagnosis samples and found no association between the factor and overall lymphoma risk, nor with any subtype, although the number of cases was small for each subtype, and further studies are necessary.
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- 2017
47. Fiber intake modulates the association of alcohol intake with breast cancer
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Romieu, Isabelle Ferrari, Pietro Chajes, Veronique de Batlle, Jordi Biessy, Carine Scoccianti, Chiara Dossus, Laure Boutron, Marie Christine Bastide, Nadia Overvad, Kim and Olsen, Anja Tjonneland, Anne Kaaks, Rudolf Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico Sieri, Sabina Tumino, Rosario and Vineis, Paolo Panico, Salvatore Bueno-de-Mesquita, H. B. (as) and Gils, Carla H. Peeters, Petra H. Lund, Eiliv Skeie, Guri and Weiderpass, Elisabete Quiros, J. Ramon Chirlaque, Maria-Dolores Ardanaz, Eva Sanchez, Maria-Jose Duell, Eric J. Etxezarreta, Pilar Amiano Borgquist, Signe Hallmans, Goran Johansson, Ingegerd Nilsson, Lena Maria Khaw, Kay-Tee and Wareham, Nick Key, Timothy J. Travis, Ruth C. Murphy, Neil Wark, Petra A. Riboli, Elio
- Abstract
Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (24.2 g/day) the risk of BC was 1.02 (0.99-1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (
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- 2017
48. Prospective association of liver function biomarkers with development of hepatobiliary cancers
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Stepien, Magdalena Fedirko, Veronika Duarte-Salles, Talita and Ferrari, Pietro Freisling, Heinz Trepo, Elisabeth and Trichopoulou, Antonia Bamia, Christina Weiderpass, Elisabete and Olsen, Anja Tjonneland, Anne Overvad, Kim Boutron-Ruault, Marie-Christine Fagherazzi, Guy Racine, Antoine Kuehn, Tilman Kaaks, Rudolf Aleksandrova, Krasimira Boeing, Heiner and Lagiou, Pagona Benetou, Vassiliki Trichopoulos, Dimitrios and Palli, Domenico Grioni, Sara Tumino, Rosario Naccarati, Alessio Panico, Salvatore Bueno-de-Mesquita, H. Bas Peeters, Petra H. Lund, Eiliv Quiros, J. Ramon Napoles, Osmel Companioni Sanchez, Maria-Jose Dorronsoro, Miren Maria Huerta, Jose Ardanaz, Eva Ohlsson, Bodil Sjoberg, Klas and Werner, Marten Nystrom, Hanna Khaw, Kay-Tee Key, Timothy J. and Gunter, Marc Cross, Amanda Riboli, Elio Romieu, Isabelle and Jenab, Mazda
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digestive system - Abstract
Introduction: Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers. Methods: A nested-case control study was conducted within the prospective EPIC cohort (>520,000 participants, 10 European countries). After a mean 7.5 mean years of follow-up, 121 hepatocellular carcinoma (HCC), 34 intrahepatic bile duct (IHBC) and 131 gallbladder and biliary tract (GBTC) cases were identified and matched to 2 controls each. Circulating biomarkers were measured in serum taken at recruitment into the cohort, prior to cancer diagnosis. Multivariable adjusted conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95% CI). Results: In multivariable models, 1SD increase of each log-transformed biomarker was positively associated with HCC risk (OR(GGT) = 4.23, 95% CI: 2.72-6.59; OR(ALP) = 3.43, 95% CI: 2.31-5.10; OR(AST) = 3.00, 95% CI: 2.04-4.42; OR(ALT) = 2.69, 95% CI: 1.89-3.84; OR(Bilirubin) = 2.25, 95% CI: 1.58-3.20). Each liver enzyme (OR(GGT) = 4.98; 95% CI: 1.75-14.17; OR(AST) = 3.10, 95% CI: 1.04-9.30; OR(ALT) = 2.86, 95% CI: 1.26-6.48, OR(ALP) = 2.31, 95% CI: 1.10-4.86) but not bilirubin (OR(Bilirubin) = 1.46,95% CI: 0.85-2.51) showed a significant association with IHBC. Only ALP was significantly associated with GBTC risk (OR (ALP) = 1.59, 95% CI: 1.20-2.09). Conclusion: This study shows positive associations between circulating liver biomarkers in sera collected prior to cancer diagnoses and the risks of developing HCC or IHBC, but not GBTC. (C) 2016 Elsevier Ltd. All rights reserved.
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- 2016
49. Burden of Cancer in a Large Consortium of Prospective Cohorts in Europe
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Tsilidis, Konstantinos K. Papadimitriou, Nikos Capothanassi, Despoina Bamia, Christina Benetou, Vassiliki Jenab, Mazda and Freisling, Heinz Kee, Frank Nelen, Annemarie O'Doherty, Mark G. Scott, Angela Soerjomataram, Isabelle Tjonneland, Anne May, Anne M. Quiros, J. Ramon Pettersson-Kymmer, Ulrika and Brenner, Hermann Schoettker, Ben Ordonez-Mena, Jose M. and Dieffenbach, Aida Karina Eriksson, Sture Mathiesen, Ellisiv Bogeberg Njolstad, Inger Siganos, Galatios Wilsgaard, Tom and Boffetta, Paolo Trichopoulos, Dimitrios Trichopoulou, Antonia
- Abstract
Background: Disability-adjusted life-years (DALYs) are an indicator of mortality, morbidity, and disability. We calculated DALYs for cancer in middle-aged and older adults participating in the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES) consortium. Methods: A total of 90 199 participants from five European cohorts with 10 455 incident cancers and 4399 deaths were included in this study. DALYs were calculated as the sum of the years of life lost because of premature mortality (YLLs) and the years lost because of disability (YLDs). Population-attributable fractions (PAFs) were also estimated for five cancer risk factors, ie, smoking, adiposity, physical inactivity, alcohol intake, and type II diabetes. Results: After a median follow-up of 12 years, the total number of DALYs lost from cancer was 34 474 (382 per 1000 individuals) with a similar distribution by sex. Lung cancer was responsible for the largest number of lost DALYs (22.9%), followed by colorectal (15.3%), prostate (10.2%), and breast cancer (8.7%). Mortality (81.6% of DALYs) predominated over disability. Ever cigarette smoking was the risk factor responsible for the greatest total cancer burden (24.0%, 95% confidence interval [CI] = 22.2% to 26.0%), followed by physical inactivity (4.9%, 95% CI = 0.8% to 8.1%) and adiposity (1.8%, 95% CI = 0.2% to 2.8%). Conclusions: DALYs lost from cancer were substantial in this large European sample of middle-aged and older adults. Even if the burden of disease because of cancer is predominantly caused by mortality, some cancers have sizeable consequences for disability. Smoking remained the predominant risk factor for total cancer burden.
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- 2016
50. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort
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Roura, Esther Travier, Noemie Waterboer, Tim de Sanjose, Silvia Bosch, F. Xavier Pawlita, Michael Pala, Valeria and Weiderpass, Elisabete Margall, Nuria Dillner, Joakim Gram, Inger T. Tjonneland, Anne Munk, Christian Palli, Domenico and Khaw, Kay-Tee Overvad, Kim Clavel-Chapelon, Franoise and Mesrine, Sylvie Fournier, Agnes Fortner, Renee T. Ose, Jennifer Steffen, Annika Trichopoulou, Antonia Lagiou, Pagona Orfanos, Philippos Masala, Giovanna Tumino, Rosario and Sacerdote, Carlotta Polidoro, Silvia Mattiello, Amalia and Lund, Eiliv Peeters, Petra H. Bueno-de-Mesquita, H. B(as). and Quiros, J. Ramon Sanchez, Maria-Jose Navarro, Carmen and Barricarte, Aurelio Larranaga, Nerea Ekstrom, Johanna and Lindquist, David Idahl, Annika Travis, Ruth C. Merritt, Melissa A. Gunter, Marc J. Rinaldi, Sabina Tommasino, Massimo Franceschi, Silvia Riboli, Elio Castellsague, Xavier
- Abstract
Background In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). Methods and Findings We followed a cohort of 308,036 women recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. At enrollment, participants completed a questionnaire and provided serum. After a 9-year median follow-up, 261 ICC and 804 CIN3/CIS cases were reported. In a nested case-control study, the sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11,16,18,31,33,35,45, 52,58, and antibodies against Chlamydia trachomatis and Human herpesvirus 2. Multivariate analyses were performed to estimate hazard ratios (HR), odds ratios (OR) and corresponding 95% confidence intervals (CI). The cohort analysis showed that number of fullterm pregnancies was positively associated with CIN3/CIS risk (p-trend = 0.03). Duration of oral contraceptives use was associated with a significantly increased risk of both CIN3/CIS and ICC (HR = 1.6 and HR = 1.8 respectively for >= 15 years versus never use). Ever use of menopausal hormone therapy was associated with a reduced risk of ICC (HR = 0.5, 95% CI: 0.4-0.8). A non-significant reduced risk of ICC with ever use of intrauterine devices (IUD) was found in the nested case-control analysis (OR = 0.6). Analyses restricted to all cases and HPV seropositive controls yielded similar results, revealing a significant inverse association with IUD for combined CIN3/CIS and ICC (OR = 0.7). Conclusions Even though HPV is the necessary cause of CC, our results suggest that several hormonal factors are risk factors for cervical carcinogenesis. Adherence to current cervical cancer screening guidelines should minimize the increased risk of CC associated with these hormonal risk factors.
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- 2016
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