163 results on '"Quirós, J.R."'
Search Results
2. Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium
- Author
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Ordóñez-Mena, J.M., Walter, V., Schöttker, B., Jenab, M., O’Doherty, M.G., Kee, F., Bueno-de-Mesquita, B., Peeters, P.H.M., Stricker, B.H., Ruiter, R., Hofman, A., Söderberg, S., Jousilahti, P., Kuulasmaa, K., Freedman, N.D., Wilsgaard, T., Wolk, A., Nilsson, L.M., Tjønneland, A., Quirós, J.R., van Duijnhoven, F J B, Siersema, P.D., Boffetta, P., Trichopoulou, A., and Brenner, H.
- Published
- 2018
- Full Text
- View/download PDF
3. The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)
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Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S.H., Stefan, D.C., El Mistiri, M.M., Bayo, S., Malle, B., Manraj, S.S., Sewpaul-Sungkur, R., Fabowale, A., Ogunbiyi, O.J., Bradshaw, D., Somdyala, N.I.M., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M.S., Laura, E.A., Espinola, S.B., Calabrano, G.H., Carballo Quintero, B., Fita, R., Garcilazo, D.A., Giacciani, P.L., Diumenjo, M.C., Laspada, W.D., Green, M.A., Lanza, M.F., Ibañez, S.G., Lima, C.A., Lobo de Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P.C.F., Melo, C.D., Del Pino, K., Laporte, C., Curado, M.P., de Oliveira, J.C., Veneziano, C.L.A., Veneziano, D.B., Alexandre, T.S., Verdugo, A.S., Azevedo e Silva, G., Galaz, J.C., Moya, J.A., Herrmann, D.A., Vargas, S., Herrera, V.M., Uribe, C.J., Bravo, L.E., Arias-Ortiz, N.E., Jurado, D.M., Yépez, M.C., Galán, Y.H., Torres, P., Martínez-Reyes, F., Pérez-Meza, M.L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J.G., Torres-Cintrón, C.R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A.J., Woods, R.R., Noonan, G., Turner, D., Kumar, E., Zhang, B., McCrate, F.R., Ryan, S., Hannah, H., Dewar, R.A.D., MacIntyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D.E., McClure, C., Vriends, K.A., Bertrand, C., Louchini, R., Robb, K.I., Stuart-Panko, H., Demers, S., Wright, S., George, J.T., Shen, X., Brockhouse, J.T., O'Brien, D.K., Ward, K.C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A.G., Vigneau, F., MacKinnon, J.A., Wohler, B., Bayakly, A.R., Clarke, C.A., Glaser, S.L., West, D., Green, M.D., Hernandez, B.Y., Johnson, C.J., Jozwik, D., Charlton, M.E., Lynch, C.F., Huang, B., Tucker, T.C., Deapen, D., Liu, L., Hsieh, M.C., Wu, X.C., Stern, K., Gershman, S.T., Knowlton, R.C., Alverson, J., Copeland, G.E., Rogers, D.B., Lemons, D., Williamson, L.L., Hood, M., Hosain, G.M., Rees, J.R., Pawlish, K.S., Stroup, A., Key, C., Wiggins, C., Kahn, A.R., Schymura, M.J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S.S., Rubertone, J.J., Slack, S.J., Fulton, J.P., Rousseau, D.L., Janes, T.A., Schwartz, S.M., Bolick, S.W., Hurley, D.M., Richards, J., Whiteside, M.A., Nogueira, L.M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D.G., Keitheri Cheteri, M.B., Farley, S., Hudson, A.G., Borchers, R., Stephenson, L., Espinoza, J.R., Weir, H.K., Edwards, B.K., Wang, N., Yang, L., Chen, J.S., Song, G.H., Gu, X.P., Zhang, P., Ge, H.M., Zhao, D.L., Zhang, J.H., Zhu, F.D., Tang, J.G., Shen, Y., Wang, J., Li, Q.L., Yang, X.P., Dong, J., Li, W., Cheng, L.P., Chen, J.G., Huang, Q.H., Huang, S.Q., Guo, G.P., Wei, K., Chen, W.Q., Zeng, H., Demetriou, A.V., Pavlou, P., Mang, W.K., Ngan, K.C., Kataki, A.C., Krishnatreya, M., Jayalekshmi, P.A., Sebastian, P., Sapkota, S.D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-Boker, L., Silverman, B.G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo Pathy, N., Chimedsuren, O., Tuvshingerel, S., Al Khater, A.H.M., Al-Eid, H., Jung, K.W., Won, Y.J., Chiang, C.J., Lai, M.S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S.L., Sriplung, H., Eser, S., Yakut, C.I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A.A., Aleinikova, O.V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A.M., Faivre, J., Guizard, A.V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A.S., Daoulas, M., Clavel, J., Le Guyader-Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S.R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R.A., Kumar, V., Ólafsdóttir, E.J., Tryggvadóttir, L., Comber, H., Walsh, P.M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M.F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M.M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M.L., Tisano, F., Fanetti, A.C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M.A., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A.P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-Sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-Lampart, M., Radziszewska, A.U., Didkowska, J.A., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R.A., Bastos, J., Silva, M.A., Antunes, L., Bento, M.J., Mayer-da-Silva, A., Miranda, A., Coza, D., Todescu, A.I., Valkov, M.Y., Adamcik, J., Safaei Diba, C., Primic-Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J.R., Bidaurrazaga, J., Larrañaga, N., Díaz García, J.M., Marcos, A.I., Marcos-Gragera, R., Vilardell Gil, M.L., Molina, E., Sánchez, M.J., Franch Sureda, P., Ramos Montserrat, M., Chirlaque, M.D., Navarro, C., Ardanaz, E.E., Moreno-Iribas, C.C., Fernández-Delgado, R., Peris-Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S.M., Herrmann, C., Bulliard, J.L., Maspoli-Conconi, M., Frick, H., Kuehni, C.E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S.I., Matthes, K.L., Rashbass, J., Stiller, C., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R.J., Brewster, D.H., Huws, D.W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M.P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M.J., Aitken, J., Scott, C., Stokes, B.C., Venn, A., Farrugia, H., Giles, G.G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Matz, Melissa, Coleman, Michel P, Sant, Milena, Chirlaque, Maria Dolores, Visser, Otto, Gore, Martin, and Allemani, Claudia
- Published
- 2017
- Full Text
- View/download PDF
4. Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)
- Author
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Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S.H., El Mistiri, M.M., Bayo, S., Malle, B., Manraj, S.S., Sewpaul-Sungkur, R., Fabowale, A., Ogunbiyi, O.J., Bradshaw, D., Somdyala, N.I.M., Stefan, D.C., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M.S., Laura, E.A., Espinola, S.B., Calabrano, G.H., Carballo Quintero, B., Fita, R., Garcilazo, D.A., Giacciani, P.L., Diumenjo, M.C., Laspada, W.D., Green, M.A., Lanza, M.F., Ibañez, S.G., Lima, C.A., Lobo de Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P.C.F., Melo, C.D., Del Pino, K., Laporte, C., Curado, M.P., de Oliveira, J.C., Veneziano, C.L.A., Veneziano, D.B., Latorre, M.R.D.O., Tanaka, L.F., Azevedo e Silva, G., Galaz, J.C., Moya, J.A., Herrmann, D.A., Vargas, S., Herrera, V.M., Uribe, C.J., Bravo, L.E., Arias-Ortiz, N.E., Jurado, D.M., Yépez, M.C., Galán, Y.H., Torres, P., Martínez-Reyes, F., Pérez-Meza, M.L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J.G., Torres-Cintrón, C.R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A.J., Woods, R.R., Noonan, G., Turner, D., Kumar, E., Zhang, B., McCrate, F.R., Ryan, S., Hannah, H., Dewar, R.A.D., MacIntyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D.E., McClure, C., Vriends, K.A., Bertrand, C., Louchini, R., Robb, K.I., Stuart-Panko, H., Demers, S., Wright, S., George, J.T., Shen, X., Brockhouse, J.T., O'Brien, D.K., Ward, K.C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A.G., Vigneau, F., MacKinnon, J.A., Wohler, B., Bayakly, A.R., Clarke, C.A., Glaser, S.L., West, D., Green, M.D., Hernandez, B.Y., Johnson, C.J., Jozwik, D., Charlton, M.E., Lynch, C.F., Huang, B., Tucker, T.C., Deapen, D., Liu, L., Hsieh, M.C., Wu, X.C., Stern, K., Gershman, S.T., Knowlton, R.C., Alverson, J., Copeland, G.E., Rogers, D.B., Lemons, D., Williamson, L.L., Hood, M., Hosain, G.M., Rees, J.R., Pawlish, K.S., Stroup, A., Key, C., Wiggins, C., Kahn, A.R., Schymura, M.J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S.S., Rubertone, J.J., Slack, S.J., Fulton, J.P., Rousseau, D.L., Janes, T.A., Schwartz, S.M., Bolick, S.W., Hurley, D.M., Richards, J., Whiteside, M.A., Nogueira, L.M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D.G., Keitheri Cheteri, M.B., Farley, S., Hudson, A.G., Borchers, R., Stephenson, L., Espinoza, J.R., Weir, H.K., Edwards, B.K., Wang, N., Yang, L., Chen, J.S., Song, G.H., Gu, X.P., Zhang, P., Ge, H.M., Zhao, D.L., Zhang, J.H., Zhu, F.D., Tang, J.G., Shen, Y., Wang, J., Li, Q.L., Yang, X.P., Dong, J., Li, W., Cheng, L.P., Chen, J.G., Huang, Q.H., Huang, S.Q., Guo, G.P., Wei, K., Chen, W.Q., Zeng, H., Demetriou, A.V., Pavlou, P., Mang, W.K., Ngan, K.C., Kataki, A.C., Krishnatreya, M., Jayalekshmi, P.A., Sebastian, P., Sapkota, S.D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-Boker, L., Silverman, B.G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo-Pathy, N., Tuvshingerel, S., Chimedsuren, O., Al Khater, A.H.M., Al-Eid, H., Jung, K.W., Won, Y.J., Chiang, C.J., Lai, M.S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S.L., Sriplung, H., Eser, S., Yakut, C.I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A.A., Aleinikova, O.V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A.M., Faivre, J., Guizard, A.V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A.S., Daoulas, M., Clavel, J., Le Guyader-Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S.R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R.A., Kumar, V., Ólafsdóttir, E.J., Tryggvadóttir, L., Comber, H., Walsh, P.M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M.F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M.M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M.L., Tisano, F., Fanetti, A.C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M.A., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A.P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-Sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-Lampart, M., Radziszewska, A.U., Didkowska, J.A., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R.A., Bastos, J., Silva, M.A., Antunes, L., Bento, M.J., Mayer-da-Silva, A., Miranda, A., Coza, D., Todescu, A.I., Valkov, M.Y., Adamcik, J., Safaei Diba, C., Primic-Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J.R., Bidaurrazaga, J., Larrañaga, N., Díaz García, J.M., Marcos, A.I., Marcos-Gragera, R., Vilardell Gil, M.L., Molina, E., Sánchez, M.J., Franch Sureda, P., Ramos Montserrat, M., Chirlaque, M.D., Navarro, C., Ardanaz, E.E., Moreno-Iribas, C.C., Fernández-Delgado, R., Peris-Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S.M., Herrmann, C., Bulliard, J.L., Maspoli-Conconi, M., Frick, H., Kuehni, C.E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S.I., Matthes, K.L., Rashbass, J., Stiller, C.A., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R.J., Brewster, D.H., Huws, D.W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M.P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M.J., Aitken, J., Scott, C., Stokes, B.C., Venn, A., Farrugia, H., Giles, G.G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Matz, Melissa, Coleman, Michel P, Carreira, Helena, Salmerón, Diego, Chirlaque, Maria Dolores, and Allemani, Claudia
- Published
- 2017
- Full Text
- View/download PDF
5. Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort
- Author
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Matejcic, M., de Batlle, J., Ricci, C., Biessy, C., Perrier, F., Huybrechts, I., Weiderpass, E., BoutronRuault, M.C., Cadeau, C., His, M., Cox, D.G., Boeing, H., Fortner, R.T., Kaaks, R., Lagiou, P., Trichopoulou, A., Benetou, V., Tumino, R., Panico, S., Sieri, S., Palli, D., Ricceri, F., BuenodeMesquita, H.B(as), Skeie, G., Amiano, P., Sánchez, M.J., Chirlaque, M.D., Barricarte, A., Quirós, J.R., Buckland, G., van Gils, C.H., Peeters, P.H., Key, T.J., Riboli, E., Gylling, B., ZeleniuchJacquotte, A., Gunter, M.J., Romieu, I., and Chajès, V.
- Published
- 2017
- Full Text
- View/download PDF
6. Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium
- Author
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Amadou, A., Freisling, H., Jenab, M., Tsilidis, K.K., Trichopoulou, A., Boffetta, P., Van Guelpen, B., Mokoroa, O., Wilsgaard, T., Kee, F., Schöttker, B., Ordóñez-Mena, J.M., Männistö, S., Söderberg, S., Vermeulen, R.C.H., Quirós, J.R., Liao, L.M., Sinha, R., Kuulasmaa, K., Brenner, H., Romieu, I., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sub Algemeen Theoretical Physics, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sub Algemeen Theoretical Physics, Amadou A., Freisling H., Jenab M., Tsilidis K.K., Trichopoulou A., Boffetta P., Van Guelpen B., Mokoroa O., Wilsgaard T., Kee F., Schottker B., Ordonez-Mena J.M., Mannisto S., Soderberg S., Vermeulen R.C.H., Quiros J.R., Liao L.M., Sinha R., Kuulasmaa K., Brenner H., and Romieu I.
- Subjects
Male ,Aging ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,Breast Neoplasms ,Colorectal Neoplasm ,Overweight ,Article ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Risk Factors ,Neoplasms ,Internal medicine ,Diabetes Mellitus ,Prevalence ,medicine ,Humans ,Prospective cohort study ,Aged ,Aged, 80 and over ,business.industry ,Risk Factor ,Hazard ratio ,Prostatic Neoplasms ,Cancer ,Diabetes Mellitu ,Middle Aged ,medicine.disease ,Obesity ,United States ,Confidence interval ,Europe ,Oncology ,030220 oncology & carcinogenesis ,Prostatic Neoplasm ,Neoplasm ,Female ,Cohort Studie ,medicine.symptom ,Colorectal Neoplasms ,business ,Breast Neoplasm ,Human - Abstract
BACKGROUND: We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity. METHODS: We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis. RESULTS: A total of 667,916 individuals were included with an overall median (P25–P75) age at recruitment of 62.3 (57–67) years. During a median follow-up time of 10.5 years, 114,404 total cancer cases were ascertained. Diabetes was not associated with the risk of all cancers combined (hazard ratio (HR) = 0.94; 95% confidence interval (CI): 0.86–1.04; I(2) = 63.3%). Diabetes was positively associated with colorectal cancer risk in men (HR = 1.17; 95% CI: 1.08–1.26; I(2) = 0%) and a similar HR in women (1.13; 95% CI: 0.82–1.56; I(2) = 46%), but with a confidence interval including the null. Diabetes was inversely associated with prostate cancer risk (HR = 0.81; 95% CI: 0.77–0.85; I(2) = 0%), but not with postmenopausal breast cancer (HR = 0.96; 95% CI: 0.89–1.03; I(2) = 0%). In exploratory subgroup analyses, diabetes was inversely associated with prostate cancer risk only in men with overweight or obesity. CONCLUSIONS: Prevalent diabetes was positively associated with colorectal cancer risk and inversely associated with prostate cancer risk in older Europeans and Americans.
- Published
- 2021
7. Diferencias sociodemográficas en la adhesión al patrón de dieta mediterránea en poblaciones de España
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González C.A., Argilaga S., Agudo A., Amiano P., Barricarte A., Beguiristain J.M., Chirlaque M.D., Dorronsoro M., Martinez C., Navarro C., Quirós J.R., Rodriguez M., and Tormo M.J.
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Dieta mediterránea ,Diferencias sociales ,Estudio transversal ,Public aspects of medicine ,RA1-1270 - Abstract
Objetivos: Los grupos de nivel social más bajo tienen habitualmente una dieta menos saludable. El objetivo de este estudio es comparar la adhesión al patrón de dieta mediterránea entre diferentes grupos demográficos y sociales de la población adulta. Métodos: Se realizó un estudio transversal en regiones del sur y norte de España, en voluntarios sanos (15.634 varones y 25.812 mujeres) de 29 a 69 años de edad, miembros de la cohorte EPIC en España. Se tuvo en cuenta el consumo de nueve grupos de alimentos para definir el patrón de dieta mediterránea: vegetales, frutas, legumbres, cereales, carne roja, pescado, aceite de oliva, leche y productos lácteos y vino. Se aplicaron dos técnicas de análisis: comparación de la media diaria de consumo de cada grupo, y el cálculo de un escore global para todos los alimentos, por nivel educacional y clase social de origen. Resultados: Los grupos de nivel educacional más bajo consumen mas cereales y legumbres, pero menos vegetales, aceite de oliva (las mujeres), leche y productos lácteos (los varones). El consumo de vino está positivamente asociado con la educación en las mujeres y negativamente asociado en los varones. Calculando una puntuación para medir la adhesión global al patrón de dieta mediterránea, las diferencias por cada grupo de alimentos se compensan, y no hay variaciones según el nivel educacional, aunque existen pequeñas diferencias en la clase social de origen (22,52 en la clase más baja y 21,98 en la clase más alta). El índice de adhesión es más bajo en los adultos jóvenes y mujeres, y ligeramente más alto en las poblaciones del sur (23,53 en Murcia) que en las del norte de España (21,64 en Asturias). Conclusiones: Los resultados sugieren que el patrón de dieta mediterránea es bastante uniforme, al menos en las poblaciones adultas de las áreas incluidas en el estudio.
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- 2002
8. Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium
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IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sub Algemeen Theoretical Physics, Amadou, A., Freisling, H., Jenab, M., Tsilidis, K.K., Trichopoulou, A., Boffetta, P., Van Guelpen, B., Mokoroa, O., Wilsgaard, T., Kee, F., Schöttker, B., Ordóñez-Mena, J.M., Männistö, S., Söderberg, S., Vermeulen, R.C.H., Quirós, J.R., Liao, L.M., Sinha, R., Kuulasmaa, K., Brenner, H., Romieu, I., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sub Algemeen Theoretical Physics, Amadou, A., Freisling, H., Jenab, M., Tsilidis, K.K., Trichopoulou, A., Boffetta, P., Van Guelpen, B., Mokoroa, O., Wilsgaard, T., Kee, F., Schöttker, B., Ordóñez-Mena, J.M., Männistö, S., Söderberg, S., Vermeulen, R.C.H., Quirós, J.R., Liao, L.M., Sinha, R., Kuulasmaa, K., Brenner, H., and Romieu, I.
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- 2021
9. Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score
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Aleksandrova, K. Reichmann, R. Kaaks, R. Jenab, M. Bueno-de-Mesquita, H.B. Dahm, C.C. Eriksen, A.K. Tjønneland, A. Artaud, F. Boutron-Ruault, M.-C. Severi, G. Hüsing, A. Trichopoulou, A. Karakatsani, A. Peppa, E. Panico, S. Masala, G. Grioni, S. Sacerdote, C. Tumino, R. Elias, S.G. May, A.M. Borch, K.B. Sandanger, T.M. Skeie, G. Sánchez, M.-J. Huerta, J.M. Sala, N. Gurrea, A.B. Quirós, J.R. Amiano, P. Berntsson, J. Drake, I. van Guelpen, B. Harlid, S. Key, T. Weiderpass, E. Aglago, E.K. Cross, A.J. Tsilidis, K.K. Riboli, E. Gunter, M.J.
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Background: Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral to screening and motivate behaviour change. We therefore developed and validated a lifestyle-based CRC risk prediction algorithm in an asymptomatic European population. Methods: The model was based on data from 255,482 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study aged 19 to 70 years who were free of cancer at study baseline (1992–2000) and were followed up to 31 September 2010. The model was validated in a sample comprising 74,403 participants selected among five EPIC centres. Over a median follow-up time of 15 years, there were 3645 and 981 colorectal cancer cases in the derivation and validation samples, respectively. Variable selection algorithms in Cox proportional hazard regression and random survival forest (RSF) were used to identify the best predictors among plausible predictor variables. Measures of discrimination and calibration were calculated in derivation and validation samples. To facilitate model communication, a nomogram and a web-based application were developed. Results: The final selection model included age, waist circumference, height, smoking, alcohol consumption, physical activity, vegetables, dairy products, processed meat, and sugar and confectionary. The risk score demonstrated good discrimination overall and in sex-specific models. Harrell’s C-index was 0.710 in the derivation cohort and 0.714 in the validation cohort. The model was well calibrated and showed strong agreement between predicted and observed risk. Random survival forest analysis suggested high model robustness. Beyond age, lifestyle data led to improved model performance overall (continuous net reclassification improvement = 0.307 (95% CI 0.264–0.352)), and especially for young individuals below 45 years (continuous net reclassification improvement = 0.364 (95% CI 0.084–0.575)). Conclusions: LiFeCRC score based on age and lifestyle data accurately identifies individuals at risk for incident colorectal cancer in European populations and could contribute to improved prevention through motivating lifestyle change at an individual level. © 2020, The Author(s).
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- 2021
10. Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Perez-Cornago, A. Crowe, F.L. Appleby, P.N. Bradbury, K.E. Wood, A.M. Jakobsen, M.U. Johnson, L. Sacerdote, C. Steur, M. Weiderpass, E. Würtz, A.M.L. Kühn, T. Katzke, V. Trichopoulou, A. Karakatsani, A. La Vecchia, C. Masala, G. Tumino, R. Panico, S. Sluijs, I. Skeie, G. Imaz, L. Petrova, D. Quirós, J.R. Yohar, S.M.C. Jakszyn, P. Melander, O. Sonestedt, E. Andersson, J. Wennberg, M. Aune, D. Riboli, E. Schulze, M.B. Di Angelantonio, E. Wareham, N.J. Danesh, J. Forouhi, N.G. Butterworth, A.S. Key, T.J.
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food and beverages - Abstract
Background: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD. Results: There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90-0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82-0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk. Conclusions: In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear. © 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.
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- 2021
11. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)
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Crusius, J.B.A., Canzian, F., Capellá, G., Peña, A.S., Pera, G., Sala, N., Agudo, A., Rico, F., Del Giudice, G., Palli, D., Plebani, M., Boeing, H., Bueno-de-Mesquita, H.B., Carneiro, F., Pala, V., Save, V.E., Vineis, P., Tumino, R., Panico, S., Berglund, G., Manjer, J., Stenling, R., Hallmans, G., Martínez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quirós, J.R., Allen, N., Key, T.J., Binghan, S., Caldas, C., Linseisen, J., Kaaks, R., Overvad, K., Tjønneland, A., Büchner, F.C., Peeters, P.H.M., Numans, M.E., Clavel-Chapelon, F., Trichopoulou, A., Lund, E., Jenab, M., Rinaldi, S., Ferrari, P., Riboli, E., and González, C.A.
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- 2008
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12. Renal replacement therapy for autosomal dominant polycystic kidney disease (ADPKD) in Europe: prevalence and survival—an analysis of data from the ERA-EDTA Registry
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Spithoven, Edwin M., Kramer, Anneke, Meijer, Esther, Orskov, Bjarne, Wanner, Christoph, Abad, Jose M., Aresté, Nuria, Alonso de la Torre, Ramón, Caskey, Fergus, Couchoud, Cécile, Finne, Patrik, Heaf, James, Hoitsma, Andries, de Meester, Johan, Pascual, Julio, Postorino, Maurizio, Ravani, Pietro, Zurriaga, Oscar, Jager, Kitty J., Gansevoort, Ron T., de los Ángeles García Bazaga, M., Metcalfe, W., Rodrigo, E., Quirós, J.R., Budde, K., Devuyst, O., Ecder, T., Eckardt, K.U., Gansevoort, R.T., Köttgen, A., Ong, A.C., Petzold, K., Pirson, Y., Remuzzi, G., Torra, R., Sandford, R.N., Serra, A.L., Tesar, V., Walz, G., Wüthrich, R.P., Antignac, C., Bindels, R., Chauveau, D., Devuyst, O., Emma, F., Gansevoort, R.T., Maxwell, P.H., Ong, A.C., Remuzzi, G., Ronco, P., and Schaefer, F.
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- 2014
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13. Healthy lifestyle and the risk of pancreatic cancer in the EPIC study
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Naudin, S. Viallon, V. Hashim, D. Freisling, H. Jenab, M. Weiderpass, E. Perrier, F. McKenzie, F. Bueno-de-Mesquita, H.B. Olsen, A. Tjønneland, A. Dahm, C.C. Overvad, K. Mancini, F.R. Rebours, V. Boutron-Ruault, M.-C. Katzke, V. Kaaks, R. Bergmann, M. Boeing, H. Peppa, E. Karakatsani, A. Trichopoulou, A. Pala, V. Masala, G. Panico, S. Tumino, R. Sacerdote, C. May, A.M. van Gils, C.H. Rylander, C. Borch, K.B. Chirlaque López, M.D. Sánchez, M.-J. Ardanaz, E. Quirós, J.R. Amiano Exezarreta, P. Sund, M. Drake, I. Regnér, S. Travis, R.C. Wareham, N. Aune, D. Riboli, E. Gunter, M.J. Duell, E.J. Brennan, P. Ferrari, P.
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Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) were diagnosed from 400,577 participants followed-up for 15 years (median). HLI scores combined smoking, alcohol intake, dietary exposure, physical activity and, in turn, overall and central adiposity using BMI (HLIBMI) and waist-to-hip ratio (WHR, HLIWHR), respectively. High values of HLI indicate adherence to healthy behaviors. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and 95% confidence intervals (CI). Sensitivity analyses were performed by excluding, in turn, each factor from the HLI score. Population attributable fractions (PAF) were estimated assuming participants’ shift to healthier lifestyles. The HRs for a one-standard deviation increment of HLIBMI and HLIWHR were 0.84 (95% CI: 0.79, 0.89; ptrend = 4.3e−09) and 0.77 (0.72, 0.82; ptrend = 1.7e−15), respectively. Exclusions of smoking from HLIWHR resulted in HRs of 0.88 (0.82, 0.94; ptrend = 4.9e−04). The overall PAF estimate was 19% (95% CI: 11%, 26%), and 14% (6%, 21%) when smoking was removed from the score. Adherence to a healthy lifestyle was inversely associated with PC risk, beyond the beneficial role of smoking avoidance. Public health measures targeting compliance with healthy lifestyles may have an impact on PC incidence. © 2019, Springer Nature B.V.
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- 2020
14. Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition
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Perez-Cornago, A. Huybrechts, I. Appleby, P.N. Schmidt, J.A. Crowe, F.L. Overvad, K. Tjønneland, A. Kühn, T. Katzke, V. Trichopoulou, A. Karakatsani, A. Peppa, E. Grioni, S. Palli, D. Sacerdote, C. Tumino, R. Bueno-de-Mesquita, H.B. Larrañaga, N. Sánchez, M.-J. Quirós, J.R. Ardanaz, E. Chirlaque, M.-D. Agudo, A. Bjartell, A. Wallström, P. Chajes, V. Tsilidis, K.K. Aune, D. Riboli, E. Travis, R.C. Key, T.J.
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The associations of individual dietary fatty acids with prostate cancer risk have not been examined comprehensively. We examined the prospective association of individual dietary fatty acids with prostate cancer risk overall, by tumor subtypes, and prostate cancer death. 142,239 men from the European Prospective Investigation into Cancer and Nutrition who were free from cancer at recruitment were included. Dietary intakes of individual fatty acids were estimated using center-specific validated dietary questionnaires at baseline and calibrated with 24-h recalls. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow-up of 13.9 years, 7,036 prostate cancer cases and 936 prostate cancer deaths were ascertained. Intakes of individual fatty acids were not related to overall prostate cancer risk. There was evidence of heterogeneity in the association of some short chain saturated fatty acids with prostate cancer risk by tumor stage (pheterogeneity < 0.015), with a positive association with risk of advanced stage disease for butyric acid (4:0; HR1SD = 1.08; 95%CI = 1.01–1.15; p-trend = 0.026). There were no associations with fatal prostate cancer, with the exception of a slightly higher risk for those who consumed more eicosenoic acid (22:1n-9c; HR1SD = 1.05; 1.00–1.11; p-trend = 0.048) and eicosapentaenoic acid (20:5n-3c; HR1SD = 1.07; 1.00–1.14; p-trend = 0.045). There was no evidence that dietary intakes of individual fatty acids were associated with overall prostate cancer risk. However, a higher intake of butyric acid might be associated with a higher risk of advanced, whereas intakes of eicosenoic and eicosapentaenoic acids might be positively associated with fatal prostate cancer risk. © 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC
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- 2020
15. Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition
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Kliemann, N. Murphy, N. Viallon, V. Freisling, H. Tsilidis, K.K. Rinaldi, S. Mancini, F.R. Fagherazzi, G. Boutron-Ruault, M.-C. Boeing, H. Schulze, M.B. Masala, G. Krogh, V. Sacerdote, C. de Magistris, M.S. Bueno-de-Mesquita, B. Weiderpass, E. Kühn, T. Kaaks, R. Jakszyn, P. Redondo-Sánchez, D. Amiano, P. Chirlaque, M.-D. Gurrea, A.B. Ericson, U. Drake, I. Nøst, T.H. Aune, D. May, A.M. Tjønneland, A. Dahm, C.C. Overvad, K. Tumino, R. Quirós, J.R. Trichopoulou, A. Karakatsani, A. La Vecchia, C. Nilsson, L.M. Riboli, E. Huybrechts, I. Gunter, M.J.
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Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness. © 2019 International Agency for Research on Cancer (IARC/WHO); licensed by UICC
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- 2020
16. A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort
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Christakoudi, S. Tsilidis, K.K. Muller, D.C. Freisling, H. Weiderpass, E. Overvad, K. Söderberg, S. Häggström, C. Pischon, T. Dahm, C.C. Zhang, J. Tjønneland, A. Halkjær, J. MacDonald, C. Boutron-Ruault, M.-C. Mancini, F.R. Kühn, T. Kaaks, R. Schulze, M.B. Trichopoulou, A. Karakatsani, A. Peppa, E. Masala, G. Pala, V. Panico, S. Tumino, R. Sacerdote, C. Quirós, J.R. Agudo, A. Sánchez, M.-J. Cirera, L. Barricarte-Gurrea, A. Amiano, P. Memarian, E. Sonestedt, E. Bueno-de-Mesquita, B. May, A.M. Khaw, K.-T. Wareham, N.J. Tong, T.Y.N. Huybrechts, I. Noh, H. Aglago, E.K. Ellingjord-Dale, M. Ward, H.A. Aune, D. Riboli, E.
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nutritional and metabolic diseases - Abstract
Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI < 18.5 kg/m2) or obese (BMI ≥ 30 kg/m2) categories, while the highest quartile of ABSI separated 18–39% of the individuals within each BMI category, which had 22–55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring. © 2020, The Author(s).
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- 2020
17. A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
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Papadimitriou, N. Muller, D. van den Brandt, P.A. Geybels, M. Patel, C.J. Gunter, M.J. Lopez, D.S. Key, T.J. Perez-Cornago, A. Ferrari, P. Vineis, P. Weiderpass, E. Boeing, H. Agudo, A. Sánchez, M.-J. Overvad, K. Kühn, T. Fortner, R.T. Palli, D. Drake, I. Bjartell, A. Santiuste, C. Bueno-de-Mesquita, B.H. Krogh, V. Tjønneland, A. Lauritzen, D.F. Gurrea, A.B. Quirós, J.R. Stattin, P. Trichopoulou, A. Martimianaki, G. Karakatsani, A. Thysell, E. Johansson, I. Ricceri, F. Tumino, R. Larrañaga, N. Khaw, K.T. Riboli, E. Tzoulaki, I. Tsilidis, K.K.
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Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR ' 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature. © 2019, The Author(s).
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- 2020
18. Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults
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Cordova, R. Knaze, V. Viallon, V. Rust, P. Schalkwijk, C.G. Weiderpass, E. Wagner, K.-H. Mayen-Chacon, A.-L. Aglago, E.K. Dahm, C.C. Overvad, K. Tjønneland, A. Halkjær, J. Mancini, F.R. Boutron-Ruault, M.-C. Fagherazzi, G. Katzke, V. Kühn, T. Schulze, M.B. Boeing, H. Trichopoulou, A. Karakatsani, A. Thriskos, P. Masala, G. Krogh, V. Panico, S. Tumino, R. Ricceri, F. Spijkerman, A. Boer, J. Skeie, G. Rylander, C. Borch, K.B. Quirós, J.R. Agudo, A. Redondo-Sánchez, D. Amiano, P. Gómez-Gómez, J.-H. Barricarte, A. Ramne, S. Sonestedt, E. Johansson, I. Esberg, A. Tong, T. Aune, D. Tsilidis, K.K. Gunter, M.J. Jenab, M. Freisling, H.
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Purpose: Advanced glycation end products (AGEs) can be formed in foods by the reaction of reducing sugars with proteins, and have been shown to induce insulin resistance and obesity in experimental studies. We examined the association between dietary AGEs intake and changes in body weight in adults over an average of 5 years of follow-up. Methods: A total of 255,170 participants aged 25–70 years were recruited in ten European countries (1992–2000) in the PANACEA study (Physical Activity, Nutrition, Alcohol, Cessation of smoking, Eating out of home in relation to Anthropometry), a sub-cohort of the EPIC (European Prospective Investigation into Cancer and Nutrition). Body weight was measured at recruitment and self-reported between 2 and 11 years later depending on the study center. A reference database for AGEs was used containing UPLC–MS/MS-measured Nε-(carboxymethyl)-lysine (CML), Nε-(1-carboxyethyl)-lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) in 200 common European foods. This reference database was matched to foods and decomposed recipes obtained from country-specific validated dietary questionnaires in EPIC and intake levels of CEL, CML, and MG-H1 were estimated. Associations between dietary AGEs intake and body weight change were estimated separately for each of the three AGEs using multilevel mixed linear regression models with center as random effect and dietary AGEs intake and relevant confounders as fixed effects. Results: A one-SD increment in CEL intake was associated with 0.111 kg (95% CI 0.087–0.135) additional weight gain over 5 years. The corresponding additional weight gain for CML and MG-H1 was 0.065 kg (0.041–0.089) and 0.034 kg (0.012, 0.057), respectively. The top six food groups contributing to AGEs intake, with varying proportions across the AGEs, were cereals/cereal products, meat/processed meat, cakes/biscuits, dairy, sugar and confectionary, and fish/shellfish. Conclusion: In this study of European adults, higher intakes of AGEs were associated with marginally greater weight gain over an average of 5 years of follow-up. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
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- 2020
19. The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: A prospective study of 418 329 participants in the EPIC cohort across nine European countries
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Tong, T.Y.N. Appleby, P.N. Key, T.J. Dahm, C.C. Overvad, K. Olsen, A. Tjønneland, A. Katzke, V. Kühn, T. Boeing, H. Karakatsani, A. Peppa, E. Trichopoulou, A. Weiderpass, E. Masala, G. Grioni, S. Panico, S. Tumino, R. Boer, J.M.A. Verschuren, W.M.M. Quirós, J.R. Agudo, A. Rodríguez-Barranco, M. Imaz, L. Chirlaque, M.-D. Moreno-Iribas, C. Engström, G. Sonestedt, E. Lind, M. Otten, J. Khaw, K.-T. Aune, D. Riboli, E. Wareham, N.J. Imamura, F. Forouhi, N.G. Di Angelantonio, E. Wood, A.M. Butterworth, A.S. Perez-Cornago, A.
- Abstract
Aim: To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results: We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated using 24-h recalls. Multivariable-adjusted Cox regressions were used to estimate hazard ratios (HRs) for ischaemic and haemorrhagic stroke associated with consumption of red and processed meat, poultry, fish, dairy foods, eggs, cereals, fruit and vegetables, legumes, nuts and seeds, and dietary fibre. For ischaemic stroke (4281 cases), lower risks were observed with higher consumption of fruit and vegetables combined (HR; 95% CI per 200 g/day higher intake, 0.87; 0.82-0.93, P-trend < 0.001), dietary fibre (per 10 g/day, 0.77; 0.69-0.86, P-trend < 0.001), milk (per 200 g/day, 0.95; 0.91-0.99, P-trend = 0.02), yogurt (per 100 g/day, 0.91; 0.85-0.97, P-trend = 0.004), and cheese (per 30 g/day, 0.88; 0.81-0.97, P-trend = 0.008), while higher risk was observed with higher red meat consumption which attenuated when adjusted for the other statistically significant foods (per 50 g/day, 1.07; 0.96-1.20, P-trend = 0.20). For haemorrhagic stroke (1430 cases), higher risk was associated with higher egg consumption (per 20 g/day, 1.25; 1.09-1.43, P-trend = 0.002). Conclusion: Risk of ischaemic stroke was inversely associated with consumption of fruit and vegetables, dietary fibre, and dairy foods, while risk of haemorrhagic stroke was positively associated with egg consumption. The apparent differences in the associations highlight the importance of examining ischaemic and haemorrhagic stroke subtypes separately. © 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.
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- 2020
20. Glycemic index, glycemic load, and risk of coronary heart disease: A pan-European cohort study
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Sieri, S. Agnoli, C. Grioni, S. Weiderpass, E. Mattiello, A. Sluijs, I. Sanchez, M.J. Jakobsen, M.U. Sweeting, M. van der Schouw, Y.T. Nilsson, L.M. Wennberg, P. Katzke, V.A. Kühn, T. Overvad, K. Tong, T.Y.N. Conchi, M.-I. Quirós, J.R. García-Torrecillas, J.M. Mokoroa, O. Gómez, J.-H. Tjønneland, A. Sonestedt, E. Trichopoulou, A. Karakatsani, A. Valanou, E. Boer, J.M.A. Monique Verschuren, W.M. Boutron-Ruault, M.-C. Fagherazzi, G. Madika, A.-L. Bergmann, M.M. Schulze, M.B. Ferrari, P. Freisling, H. Lennon, H. Sacerdote, C. Masala, G. Tumino, R. Riboli, E. Wareham, N.J. Danesh, J. Forouhi, N.G. Butterworth, A.S. Krogh, V.
- Abstract
Background: High carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index (GI) and glycemic load (GL) are associated with increased CHD risk. Objectives: The aim of this study was to determine whether dietary GI, GL, and available carbohydrates are associated with CHD risk in both sexes. Methods: This large prospective study-the European Prospective Investigation into Cancer and Nutrition-consisted of 338,325 participants who completed a dietary questionnaire. HRs with 95% CIs for a CHD event, in relation to intake of GI, GL, and carbohydrates, were estimated using covariate-adjusted Cox proportional hazard models. Results: After 12.8 y (median), 6378 participants had experienced a CHD event. High GL was associated with greater CHD risk [HR 1.16 (95% CI: 1.02, 1.31) highest vs. lowest quintile, p-trend 0.035; HR 1.18 (95% CI: 1.07, 1.29) per 50 g/day of GL intake]. The association between GL and CHD risk was evident in subjects with BMI (in kg/m2) =25 [HR: 1.22 (95% CI: 1.11, 1.35) per 50 g/d] but not in those with BMI
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- 2020
21. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
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Li, C. (Chen), Stoma, S. (Svetlana), Lotta, L.A. (Luca A.), Warner, S. (Sophie), Albrecht, E. (Eva), Allione, A. (Alessandra), Arp, P.P. (Pascal), Broer, L. (Linda), Buxton, J.L. (Jessica L.), Da Silva Couto Alves, A. (Alexessander), Deelen, J. (Joris), Fedko, I.O. (Iryna O.), Gordon, S.D. (Scott D.), Jiang, T. (Tao), Karlsson, R. (Robert), Kerrison, N. (Nicola), Loe, T.K. (Taylor K.), Mangino, M. (Massimo), Milaneschi, Y. (Yuri), Miraglio, B. (Benjamin), Pervjakova, N. (Natalia), Russo, A. (Alessia), Surakka, I. (Ida), Spek, A. (Ashley) van der, Verhoeven, J.E. (Josine E.), Amin, N. (Najaf), Beekman, M. (Marian), Blakemore, A.I. (Alexandra I.), Canzian, F. (Federico), Hamby, S.E. (Stephen E.), Hottenga, J.J. (Jouke Jan), Jones, P.D. (Peter D.), Jousilahti, P. (Pekka), Mägi, R. (Reedik), Medland, S.E. (Sarah), Montgomery, G.W. (Grant), Nyholt, D.R. (Dale), Perola, M. (Markus), Pietilainen, K.H. (Kirsi Hannele), Salomaa, V. (Veikko), Sillanpää, E. (Elina), Suchiman, H.E. (H. Eka), Heemst, D. (Diana) van, Willemsen, G. (Gonneke), Agudo, A. (Antonio), Boeing, H. (Heiner), Boomsma, D.I. (Dorret), Chirlaque, M.D. (M.), Fagherazzi, G. (Guy), Ferrari, P. (Pietro), Franks, P. (Paul), Gieger, C. (Christian), Hagen, K. (Knut), Gunter, M.J. (Marc J.), Hägg, S. (Sara), Hovatta, I. (Iiris), Imaz, L. (Liher), Kaprio, J. (Jaakko), Kaaks, R. (Rudolf), Key, T. (Tim), Krogh, V. (Vittorio), Martin, N.G. (Nicholas), Melander, O. (Olle), Metspalu, A. (Andres), Moreno, C. (Concha), Onland-Moret, N.C. (N. Charlotte), Nilsson, P. (Peter), Ong, K.K. (Ken K.), Overvad, K. (Kim), Palli, D. (Domenico), Panico, S. (Salvatore), Pedersen, N.L. (Nancy), Penninx, B.W.J.H. (Brenda), Quirós, J.R., Jarvelin, M.R. (Marjo Riitta), Rodríguez-Barranco, M. (Miguel), Scott, R.A. (Robert A.), Severi, G. (Gianluca), Slagboom, P.E. (Eline), Spector, T.D. (Timothy), Tjønneland, A. (Anne), Trichopoulou, A. (Antonia), Tumino, R. (Rosario), Uitterlinden, A.G. (André G.), Schouw, Y.T. (Yvonne) van der, Duijn, C.M. (Cornelia) van, Weiderpass, E. (Elisabete), Denchi, E.L. (Eros Lazzerini), Matullo, G., Butterworth, A.S. (Adam S.), Danesh, J. (John), Samani, N.J. (Nilesh), Wareham, N.J. (Nick), Nelson, C.P. (Christopher P.), Langenberg, C. (Claudia), Codd, V. (Veryan), Li, C. (Chen), Stoma, S. (Svetlana), Lotta, L.A. (Luca A.), Warner, S. (Sophie), Albrecht, E. (Eva), Allione, A. (Alessandra), Arp, P.P. (Pascal), Broer, L. (Linda), Buxton, J.L. (Jessica L.), Da Silva Couto Alves, A. (Alexessander), Deelen, J. (Joris), Fedko, I.O. (Iryna O.), Gordon, S.D. (Scott D.), Jiang, T. (Tao), Karlsson, R. (Robert), Kerrison, N. (Nicola), Loe, T.K. (Taylor K.), Mangino, M. (Massimo), Milaneschi, Y. (Yuri), Miraglio, B. (Benjamin), Pervjakova, N. (Natalia), Russo, A. (Alessia), Surakka, I. (Ida), Spek, A. (Ashley) van der, Verhoeven, J.E. (Josine E.), Amin, N. (Najaf), Beekman, M. (Marian), Blakemore, A.I. (Alexandra I.), Canzian, F. (Federico), Hamby, S.E. (Stephen E.), Hottenga, J.J. (Jouke Jan), Jones, P.D. (Peter D.), Jousilahti, P. (Pekka), Mägi, R. (Reedik), Medland, S.E. (Sarah), Montgomery, G.W. (Grant), Nyholt, D.R. (Dale), Perola, M. (Markus), Pietilainen, K.H. (Kirsi Hannele), Salomaa, V. (Veikko), Sillanpää, E. (Elina), Suchiman, H.E. (H. Eka), Heemst, D. (Diana) van, Willemsen, G. (Gonneke), Agudo, A. (Antonio), Boeing, H. (Heiner), Boomsma, D.I. (Dorret), Chirlaque, M.D. (M.), Fagherazzi, G. (Guy), Ferrari, P. (Pietro), Franks, P. (Paul), Gieger, C. (Christian), Hagen, K. (Knut), Gunter, M.J. (Marc J.), Hägg, S. (Sara), Hovatta, I. (Iiris), Imaz, L. (Liher), Kaprio, J. (Jaakko), Kaaks, R. (Rudolf), Key, T. (Tim), Krogh, V. (Vittorio), Martin, N.G. (Nicholas), Melander, O. (Olle), Metspalu, A. (Andres), Moreno, C. (Concha), Onland-Moret, N.C. (N. Charlotte), Nilsson, P. (Peter), Ong, K.K. (Ken K.), Overvad, K. (Kim), Palli, D. (Domenico), Panico, S. (Salvatore), Pedersen, N.L. (Nancy), Penninx, B.W.J.H. (Brenda), Quirós, J.R., Jarvelin, M.R. (Marjo Riitta), Rodríguez-Barranco, M. (Miguel), Scott, R.A. (Robert A.), Severi, G. (Gianluca), Slagboom, P.E. (Eline), Spector, T.D. (Timothy), Tjønneland, A. (Anne), Trichopoulou, A. (Antonia), Tumino, R. (Rosario), Uitterlinden, A.G. (André G.), Schouw, Y.T. (Yvonne) van der, Duijn, C.M. (Cornelia) van, Weiderpass, E. (Elisabete), Denchi, E.L. (Eros Lazzerini), Matullo, G., Butterworth, A.S. (Adam S.), Danesh, J. (John), Samani, N.J. (Nilesh), Wareham, N.J. (Nick), Nelson, C.P. (Christopher P.), Langenberg, C. (Claudia), and Codd, V. (Veryan)
- Abstract
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1, PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.
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- 2020
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22. Development and validation of circulating CA125 prediction models in postmenopausal women
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Sasamoto, N. Babic, A. Rosner, B.A. Fortner, R.T. Vitonis, A.F. Yamamoto, H. Fichorova, R.N. Titus, L.J. Tjønneland, A. Hansen, L. Kvaskoff, M. Fournier, A. Mancini, F.R. Boeing, H. Trichopoulou, A. Peppa, E. Karakatsani, A. Palli, D. Grioni, S. Mattiello, A. Tumino, R. Fiano, V. Onland-Moret, N.C. Weiderpass, E. Gram, I.T. Quirós, J.R. Lujan-Barroso, L. Sánchez, M.-J. Colorado-Yohar, S. Barricarte, A. Amiano, P. Idahl, A. Lundin, E. Sartor, H. Khaw, K.-T. Key, T.J. Muller, D. Riboli, E. Gunter, M. Dossus, L. Trabert, B. Wentzensen, N. Kaaks, R. Cramer, D.W. Tworoger, S.S. Terry, K.L.
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endocrine system diseases ,female genital diseases and pregnancy complications - Abstract
Background: Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker. Methods: We developed and validated linear and dichotomous (≥35 U/mL) circulating CA125 prediction models in postmenopausal women without ovarian cancer who participated in one of five large population-based studies: Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, n = 26,981), European Prospective Investigation into Cancer and Nutrition (EPIC, n = 861), the Nurses' Health Studies (NHS/NHSII, n = 81), and the New England Case Control Study (NEC, n = 923). The prediction models were developed using stepwise regression in PLCO and validated in EPIC, NHS/NHSII and NEC. Result: The linear CA125 prediction model, which included age, race, body mass index (BMI), smoking status and duration, parity, hysterectomy, age at menopause, and duration of hormone therapy (HT), explained 5% of the total variance of CA125. The correlation between measured and predicted CA125 was comparable in PLCO testing dataset (r = 0.18) and external validation datasets (r = 0.14). The dichotomous CA125 prediction model included age, race, BMI, smoking status and duration, hysterectomy, time since menopause, and duration of HT with AUC of 0.64 in PLCO and 0.80 in validation dataset. Conclusions: The linear prediction model explained a small portion of the total variability of CA125, suggesting the need to identify novel predictors of CA125. The dichotomous prediction model showed moderate discriminatory performance which validated well in independent dataset. Our dichotomous model could be valuable in identifying healthy women who may have elevated CA125 levels, which may contribute to reducing false positive tests using CA125 as screening biomarker. © 2019 The Author(s).
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- 2019
23. Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Ward, H.A. Whitman, J. Muller, D.C. Johansson, M. Jakszyn, P. Weiderpass, E. Palli, D. Fanidi, A. Vermeulen, R. Tjønneland, A. Hansen, L. Dahm, C.C. Overvad, K. Severi, G. Boutron-Ruault, M.-C. Affret, A. Kaaks, R. Fortner, R. Boeing, H. Trichopoulou, A. La Vecchia, C. Kotanidou, A. Berrino, F. Krogh, V. Tumino, R. Ricceri, F. Panico, S. Bueno-de-Mesquita, H.B. Peeters, P.H. Nøst, T.H. Sandanger, T.M. Quirós, J.R. Agudo, A. Rodríguez-Barranco, M. Larrañaga, N. Huerta, J.M. Ardanaz, E. Drake, I. Brunnström, H. Johansson, M. Grankvist, K. Travis, R.C. Freisling, H. Stepien, M. Merritt, M.A. Riboli, E. Cross, A.J.
- Abstract
Background: Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confounding. Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 416,746 individuals from 10 countries completed demographic and dietary questionnaires at recruitment. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident lung cancer (n = 3731) risk relative to haem iron, non-haem iron, and total dietary iron intake. A corresponding analysis was conducted among a nested subset of 800 lung cancer cases and 1489 matched controls for whom serum cotinine was available. Results: Haem iron was associated with lung cancer risk, including after adjustment for details of smoking history (time since quitting, number of cigarettes per day): as a continuous variable (HR per 0.3 mg/1000 kcal 1.03, 95% CI 1.00–1.07), and in the highest versus lowest quintile (HR 1.16, 95% CI 1.02–1.32; trend across quintiles: P = 0.035). In contrast, non-haem iron intake was related inversely with lung cancer risk; however, this association attenuated after adjustment for smoking history. Additional adjustment for serum cotinine did not considerably alter the associations detected in the nested case–control subset. Conclusions: Greater haem iron intake may be modestly associated with lung cancer risk. © 2018, Springer Nature Limited.
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- 2019
24. Association of selenoprotein and selenium pathway genotypes with risk of colorectal cancer and interaction with selenium status
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Fedirko, V. Jenab, M. Méplan, C. Jones, J.S. Zhu, W. Schomburg, L. Siddiq, A. Hybsier, S. Overvad, K. Tjønneland, A. Omichessan, H. Perduca, V. Boutron-Ruault, M.-C. Kühn, T. Katzke, V. Aleksandrova, K. Trichopoulou, A. Karakatsani, A. Kotanidou, A. Tumino, R. Panico, S. Masala, G. Agnoli, C. Naccarati, A. Bueno-De-Mesquita, B. Vermeulen, R.C.H. Weiderpass, E. Skeie, G. Nøst, T.H. Lujan-Barroso, L. Quirós, J.R. Huerta, J.M. Rodríguez-Barranco, M. Barricarte, A. Gylling, B. Harlid, S. Bradbury, K.E. Wareham, N. Khaw, K.-T. Gunter, M. Murphy, N. Freisling, H. Tsilidis, K. Aune, D. Riboli, E. Hesketh, J.E. Hughes, D.J.
- Abstract
Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengate assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P < 0.1). SNPs in Wingless/Integrated (Wnt) and Transforming growth factor (TGF) beta-signaling genes (FRZB, SMAD3, SMAD7) from pathways affected by Se intake were also associated with CRC risk after multiple testing adjustments. Interactions with Se status (using existing serum Se and Selenoprotein P data) were tested at the SNP, gene, and pathway levels. Pathway analyses using the modified Adaptive Rank Truncated Product method suggested that genes and gene x Se status interactions in antioxidant, apoptosis, and TGF-beta signaling pathways may be associated with CRC risk. This study suggests that SNPs in the Se pathway alone or in combination with suboptimal Se status may contribute to CRC development. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
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- 2019
25. Timing of eating across ten European countries - Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study
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Huseinovic, E. Winkvist, A. Freisling, H. Slimani, N. Boeing, H. Buckland, G. Schwingshackl, L. Olsen, A. Tjonneland, A. Stepien, M. Boutron-Ruault, M.-C. Mancini, F. Artaud, F. Kühn, T. Katzke, V. Trichopoulou, A. Naska, A. Orfanos, P. Tumino, R. Masala, G. Krogh, V. Santucci De Magistris, M. Ocké, M.C. Brustad, M. Jensen, T.E. Skeie, G. Rodríguez-Barranco, M. Huerta, J.M. Ardanaz, E. Quirós, J.R. Jakszyn, P. Sonestedt, E. Ericson, U. Wennberg, M. Key, T.J. Aune, D. Riboli, E. Weiderpass, E. Bertéus Forslund, H.
- Abstract
Objective To examine timing of eating across ten European countries.Design Cross-sectional analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study using standardized 24 h diet recalls collected during 1995-2000. Eleven predefined food consumption occasions were assessed during the recall interview. We present time of consumption of meals and snacks as well as the later:earlier energy intake ratio, with earlier and later intakes defined as 06.00-14.00 and 15.00-24.00 hours, respectively. Type III tests were used to examine associations of sociodemographic, lifestyle and health variables with timing of energy intake.Setting Ten Western European countries.Subjects In total, 22 985 women and 13 035 men aged 35-74 years (n 36 020).Results A south-north gradient was observed for timing of eating, with later consumption of meals and snacks in Mediterranean countries compared with Central and Northern European countries. However, the energy load was reversed, with the later:earlier energy intake ratio ranging from 0·68 (France) to 1·39 (Norway) among women, and from 0·71 (Greece) to 1·35 (the Netherlands) among men. Among women, country, age, education, marital status, smoking, day of recall and season were all independently associated with timing of energy intake (all P
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- 2019
26. Reproductive and Lifestyle Factors and Circulating sRANKL and OPG Concentrations in Women: Results from the EPIC Cohort
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Sarink, D. Yang, J. Johnson, T. Chang-Claude, J. Overvad, K. Olsen, A. Tjønneland, A. Fournier, A. Mancini, F.R. Kvaskoff, M. Boeing, H. Trichopoulou, A. Karakatsani, A. Valanou, E. Agnoli, C. Sacerdote, C. Masala, G. Mattiello, A. Tumino, R. Van Gils, C.H. Skeie, G. Gram, I.T. Weiderpass, E. Lujan-Barroso, L. Petrova, D. Santiuste, C. Quirós, J.R. Barricarte, A. Amiano, P. Travis, R.C. Gunter, M. Dossus, L. Christakoudi, S. Kaaks, R. Fortner, R.T.
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musculoskeletal diseases - Abstract
Background: Except for a documented increase in osteoprotegerin (OPG) concentrations with older age, data on determinants of soluble Receptor Activator of Nuclear Factor kB (sRANKL) and OPG concentrations in women are limited. We evaluated reproductive and lifestyle factors as potential sources of variation in circulating sRANKL and OPG concentrations in pre- and postmenopausal women. Methods: This study includes 2,016 controls [n = 1,552 (76%) postmenopausal, n = 757 (38%) using postmenopausal hormone therapy (PMH)] from a breast cancer case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Serum sRANKL was measured using an ELISA and serum OPG using an electrochemiluminescent assay. Generalized linear models were used to evaluate associations between these analytes and reproductive and lifestyle factors. Results: Older age at blood collection was associated with lower sRANKL concentrations in postmenopausal women (Ptrend < 0.03) and higher OPG concentrations in all women (Ptrend < 0.01). Longer duration of oral contraceptive use among premenopausal women and postmenopausal PMH users was associated with higher OPG (Ptrend < 0.04). In postmenopausal non-PMH users, sRANKL concentrations were lower with longer duration of oral contraceptive use and current (vs. never) smoking (P < 0.01). sRANKL concentrations were higher among women with higher BMI (Ptrend < 0.01). The evaluated factors accounted for 12% of the variation in sRANKL concentrations and 21% of the variation in OPG concentrations. Conclusions: Circulating sRANKL and OPG concentrations are minimally impacted by hormone-related factors in pre- and postmenopausal women. Impact: This study suggests circulating concentrations of sRANKL and OPG are unlikely to be strongly modified by hormone-related reproductive and lifestyle factors. © 2019 American Association for Cancer Research.
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- 2019
27. Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease: A Prospective Study of 7198 Incident Cases among 409 885 Participants in the Pan-European EPIC Cohort
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Key, T.J. Appleby, P.N. Bradbury, K.E. Sweeting, M. Wood, A. Johansson, I. Kühn, T. Steur, M. Weiderpass, E. Wennberg, M. Lund Würtz, A.M. Agudo, A. Andersson, J. Arriola, L. Boeing, H. Boer, J.M.A. Bonnet, F. Boutron-Ruault, M.-C. Cross, A.J. Ericson, U. Fagherazzi, G. Ferrari, P. Gunter, M. Huerta, J.M. Katzke, V. Khaw, K.-T. Krogh, V. La Vecchia, C. Matullo, G. Moreno-Iribas, C. Naska, A. Nilsson, L.M. Olsen, A. Overvad, K. Palli, D. Panico, S. Molina-Portillo, E. Quirós, J.R. Skeie, G. Sluijs, I. Sonestedt, E. Stepien, M. Tjønneland, A. Trichopoulou, A. Tumino, R. Tzoulaki, I. Van Der Schouw, Y.T. Verschuren, W.M.M. Di Angelantonio, E. Langenberg, C. Forouhi, N. Wareham, N. Butterworth, A. Riboli, E. Danesh, J.
- Abstract
Background: There is uncertainty about the relevance of animal foods to the pathogenesis of ischemic heart disease (IHD). We examined meat, fish, dairy products, and eggs and risk for IHD in the pan-European EPIC cohort (European Prospective Investigation Into Cancer and Nutrition). Methods: In this prospective study of 409 885 men and women in 9 European countries, diet was assessed with validated questionnaires and calibrated with 24-hour recalls. Lipids and blood pressure were measured in a subsample. During a mean of 12.6 years of follow-up, 7198 participants had a myocardial infarction or died of IHD. The relationships of animal foods with risk were examined with Cox regression with adjustment for other animal foods and relevant covariates. Results: The hazard ratio (HR) for IHD was 1.19 (95% CI, 1.06-1.33) for a 100-g/d increment in intake of red and processed meat, and this remained significant after exclusion of the first 4 years of follow-up (HR, 1.25 [95% CI, 1.09-1.42]). Risk was inversely associated with intakes of yogurt (HR, 0.93 [95% CI, 0.89-0.98] per 100-g/d increment), cheese (HR, 0.92 [95% CI, 0.86-0.98] per 30-g/d increment), and eggs (HR, 0.93 [95% CI, 0.88-0.99] per 20-g/d increment); the associations with yogurt and eggs were attenuated and nonsignificant after exclusion of the first 4 years of follow-up. Risk was not significantly associated with intakes of poultry, fish, or milk. In analyses modeling dietary substitutions, replacement of 100 kcal/d from red and processed meat with 100 kcal/d from fatty fish, yogurt, cheese, or eggs was associated with ≈20% lower risk of IHD. Consumption of red and processed meat was positively associated with serum non-high-density lipoprotein cholesterol concentration and systolic blood pressure, and consumption of cheese was inversely associated with serum non-high-density lipoprotein cholesterol. Conclusions: Risk for IHD was positively associated with consumption of red and processed meat and inversely associated with consumption of yogurt, cheese, and eggs, although the associations with yogurt and eggs may be influenced by reverse causation bias. It is not clear whether the associations with red and processed meat and cheese reflect causality, but they were consistent with the associations of these foods with plasma non-high-density lipoprotein cholesterol and for red and processed meat with systolic blood pressure, which could mediate such effects. © 2018 American Heart Association, Inc.
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- 2019
28. Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study
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Murphy, N. Ward, H.A. Jenab, M. Rothwell, J.A. Boutron-Ruault, M.-C. Carbonnel, F. Kvaskoff, M. Kaaks, R. Kühn, T. Boeing, H. Aleksandrova, K. Weiderpass, E. Skeie, G. Borch, K.B. Tjønneland, A. Kyrø, C. Overvad, K. Dahm, C.C. Jakszyn, P. Sánchez, M.-J. Gil, L. Huerta, J.M. Barricarte, A. Quirós, J.R. Khaw, K.-T. Wareham, N. Bradbury, K.E. Trichopoulou, A. La Vecchia, C. Karakatsani, A. Palli, D. Grioni, S. Tumino, R. Fasanelli, F. Panico, S. Bueno-de-Mesquita, B. Peeters, P.H. Gylling, B. Myte, R. Jirström, K. Berntsson, J. Xue, X. Riboli, E. Cross, A.J. Gunter, M.J.
- Abstract
Background & Aims: Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most studies have been of insufficient size to identify heterogeneous associations with precision. Methods: In the European Prospective Investigation into Cancer and Nutrition study, we used multivariable joint Cox proportional hazards models, which accounted for tumors at different anatomical sites (proximal colon, distal colon, and rectum) as competing risks, to examine the relationships between 14 established/suspected lifestyle, anthropometric, and reproductive/menstrual risk factors with colorectal cancer risk. Heterogeneity across sites was tested using Wald tests. Results: After a median of 14.9 years of follow-up of 521,330 men and women, 6291 colorectal cancer cases occurred. Physical activity was related inversely to proximal colon and distal colon cancer, but not to rectal cancer (P heterogeneity = .03). Height was associated positively with proximal and distal colon cancer only, but not rectal cancer (P heterogeneity = .0001). For men, but not women, heterogeneous relationships were observed for body mass index (P heterogeneity = .008) and waist circumference (P heterogeneity = .03), with weaker positive associations found for rectal cancer, compared with proximal and distal colon cancer. Current smoking was associated with a greater risk of rectal and proximal colon cancer, but not distal colon cancer (P heterogeneity = .05). No heterogeneity by anatomical site was found for alcohol consumption, diabetes, nonsteroidal anti-inflammatory drug use, and reproductive/menstrual factors. Conclusions: The relationships between physical activity, anthropometry, and smoking with colorectal cancer risk differed by subsite, supporting the hypothesis that tumors in different anatomical regions may have distinct etiologies. © 2019 AGA Institute
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- 2019
29. Association between Soft Drink Consumption and Mortality in 10 European Countries
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Mullee, A. Romaguera, D. Pearson-Stuttard, J. Viallon, V. Stepien, M. Freisling, H. Fagherazzi, G. Mancini, F.R. Boutron-Ruault, M.-C. Kühn, T. Kaaks, R. Boeing, H. Aleksandrova, K. Tjønneland, A. Halkjær, J. Overvad, K. Weiderpass, E. Skeie, G. Parr, C.L. Quirós, J.R. Agudo, A. Sánchez, M.-J. Amiano, P. Cirera, L. Ardanaz, E. Khaw, K.-T. Tong, T.Y.N. Schmidt, J.A. Trichopoulou, A. Martimianaki, G. Karakatsani, A. Palli, D. Agnoli, C. Tumino, R. Sacerdote, C. Panico, S. Bueno-De-Mesquita, B. Verschuren, W.M.M. Boer, J.M.A. Vermeulen, R. Ramne, S. Sonestedt, E. Van Guelpen, B. Holgersson, P.L. Tsilidis, K.K. Heath, A.K. Muller, D. Riboli, E. Gunter, M.J. Murphy, N.
- Abstract
Importance: Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date. Objective: To examine the association between total, sugar-sweetened, and artificially sweetened soft drink consumption and subsequent total and cause-specific mortality. Design, Setting, and Participants: This population-based cohort study involved participants (n = 451743 of the full cohort) in the European Prospective Investigation into Cancer and Nutrition (EPIC), an ongoing, large multinational cohort of people from 10 European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Norway, Spain, Sweden, and the United Kingdom), with participants recruited between January 1, 1992, and December 31, 2000. Excluded participants were those who reported cancer, heart disease, stroke, or diabetes at baseline; those with implausible dietary intake data; and those with missing soft drink consumption or follow-up information. Data analyses were performed from February 1, 2018, to October 1, 2018. Exposure: Consumption of total, sugar-sweetened, and artificially sweetened soft drinks. Main Outcomes and Measures: Total mortality and cause-specific mortality. Hazard ratios (HRs) and 95% CIs were estimated using multivariable Cox proportional hazards regression models adjusted for other mortality risk factors. Results: In total, 521 330 individuals were enrolled. Of this total, 451743 (86.7%) were included in the study, with a mean (SD) age of 50.8 (9.8) years and with 321081 women (71.1%). During a mean (range) follow-up of 16.4 (11.1 in Greece to 19.2 in France) years, 41693 deaths occurred. Higher all-cause mortality was found among participants who consumed 2 or more glasses per day (vs consumers of
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- 2019
30. Prospective analysis of circulating metabolites and breast cancer in EPIC
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His, M. Viallon, V. Dossus, L. Gicquiau, A. Achaintre, D. Scalbert, A. Ferrari, P. Romieu, I. Onland-Moret, N.C. Weiderpass, E. Dahm, C.C. Overvad, K. Olsen, A. Tjønneland, A. Fournier, A. Rothwell, J.A. Severi, G. Kühn, T. Fortner, R.T. Boeing, H. Trichopoulou, A. Karakatsani, A. Martimianaki, G. Masala, G. Sieri, S. Tumino, R. Vineis, P. Panico, S. Van Gils, C.H. Nøst, T.H. Sandanger, T.M. Skeie, G. Quirós, J.R. Agudo, A. Sánchez, M.-J. Amiano, P. Huerta, J.M. Ardanaz, E. Schmidt, J.A. Travis, R.C. Riboli, E. Tsilidis, K.K. Christakoudi, S. Gunter, M.J. Rinaldi, S.
- Abstract
Background: Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk. Methods: A nested case-control study was established within the European Prospective Investigation into Cancer cohort, which included 1624 first primary incident invasive breast cancer cases (with known estrogen and progesterone receptor and HER2 status) and 1624 matched controls. Metabolites (n = 127, acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexose, sphingolipids) were measured by mass spectrometry in pre-diagnostic plasma samples and tested for associations with breast cancer incidence using multivariable conditional logistic regression. Results: Among women not using hormones at baseline (n = 2248), and after control for multiple tests, concentrations of arginine (odds ratio [OR] per SD = 0.79, 95% confidence interval [CI] = 0.70-0.90), asparagine (OR = 0.83 (0.74-0.92)), and phosphatidylcholines (PCs) ae C36:3 (OR = 0.83 (0.76-0.90)), aa C36:3 (OR = 0.84 (0.77-0.93)), ae C34:2 (OR = 0.85 (0.78-0.94)), ae C36:2 (OR = 0.85 (0.78-0.88)), and ae C38:2 (OR = 0.84 (0.76-0.93)) were inversely associated with breast cancer risk, while the acylcarnitine C2 (OR = 1.23 (1.11-1.35)) was positively associated with disease risk. In the overall population, C2 (OR = 1.15 (1.06-1.24)) and PC ae C36:3 (OR = 0.88 (0.82-0.95)) were associated with risk of breast cancer, and these relationships did not differ by breast cancer subtype, age at diagnosis, fasting status, menopausal status, or adiposity. Conclusions: These findings point to potentially novel pathways and biomarkers of breast cancer development. Results warrant replication in other epidemiological studies. © 2019 The Author(s).
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- 2019
31. Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study
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Perrier, F. Viallon, V. Ambatipudi, S. Ghantous, A. Cuenin, C. Hernandez-Vargas, H. Chajès, V. Baglietto, L. Matejcic, M. Moreno-Macias, H. Kühn, T. Boeing, H. Karakatsani, A. Kotanidou, A. Trichopoulou, A. Sieri, S. Panico, S. Fasanelli, F. Dolle, M. Onland-Moret, C. Sluijs, I. Weiderpass, E. Quirós, J.R. Agudo, A. Huerta, J.M. Ardanaz, E. Dorronsoro, M. Tong, T.Y.N. Tsilidis, K. Riboli, E. Gunter, M.J. Herceg, Z. Ferrari, P. Romieu, I.
- Abstract
Background: There is increasing evidence that folate, an important component of one-carbon metabolism, modulates the epigenome. Alcohol, which can disrupt folate absorption, is also known to affect the epigenome. We investigated the association of dietary folate and alcohol intake on leukocyte DNA methylation levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Leukocyte genome-wide DNA methylation profiles on approximately 450,000 CpG sites were acquired with Illumina HumanMethylation 450K BeadChip measured among 450 women control participants of a case-control study on breast cancer nested within the EPIC cohort. After data preprocessing using surrogate variable analysis to reduce systematic variation, associations of DNA methylation with dietary folate and alcohol intake, assessed with dietary questionnaires, were investigated using CpG site-specific linear models. Specific regions of the methylome were explored using differentially methylated region (DMR) analysis and fused lasso (FL) regressions. The DMR analysis combined results from the feature-specific analysis for a specific chromosome and using distances between features as weights whereas FL regression combined two penalties to encourage sparsity of single features and the difference between two consecutive features. Results: After correction for multiple testing, intake of dietary folate was not associated with methylation level at any DNA methylation site, while weak associations were observed between alcohol intake and methylation level at CpG sites cg03199996 and cg07382687, with q val = 0.029 and q val = 0.048, respectively. Interestingly, the DMR analysis revealed a total of 24 and 90 regions associated with dietary folate and alcohol, respectively. For alcohol intake, 6 of the 15 most significant DMRs were identified through FL. Conclusions: Alcohol intake was associated with methylation levels at two CpG sites. Evidence from DMR and FL analyses indicated that dietary folate and alcohol intake may be associated with genomic regions with tumor suppressor activity such as the GSDMD and HOXA5 genes. These results were in line with the hypothesis that epigenetic mechanisms play a role in the association between folate and alcohol, although further studies are warranted to clarify the importance of these mechanisms in cancer. © 2019 The Author(s).
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- 2019
32. Determinants of health system delay among confirmed tuberculosis cases in Spain
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Díez, M., Bleda, M.J., Alcaide, J., Castells, C., Cardenal, J.I., Domínguez, A., Gayoso, P., Guitiérrez, G., Huerta, C., López, M.J., Moreno, T., Muñoz, F., García-Fulgueiras, A., Picó, M., Pozo, F., Quirós, J.R., Robles, F., Sánchez, J.M., Vanaclocha, H., and Vega, T.
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- 2005
33. Determinants of patient delay among tuberculosis cases in Spain
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Díez, M., Bleda, M.J., Alcaide, J., Caloto, T., Castells, C., Cardenal, J.I., Domínguez, A., Gayoso, P., Gutiérrez, G., Huerta, C., López, M.J., Moreno, T., Muñoz, F., Navarro, C., Picó, M., Pozo, F., Quirós, J.R., Robles, F., Sánchez, J.M., Vanaclocha, H., and Vega, T.
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- 2004
34. Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study
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Naudin, S. Li, K. Jaouen, T. Assi, N. Kyrø, C. Tjønneland, A. Overvad, K. Boutron-Ruault, M.-C. Rebours, V. Védié, A.-L. Boeing, H. Kaaks, R. Katzke, V. Bamia, C. Naska, A. Trichopoulou, A. Berrino, F. Tagliabue, G. Palli, D. Panico, S. Tumino, R. Sacerdote, C. Peeters, P.H. Bueno-de-Mesquita, H.B. Weiderpass, E. Gram, I.T. Skeie, G. Chirlaque, M.-D. Rodríguez-Barranco, M. Barricarte, A. Quirós, J.R. Dorronsoro, M. Johansson, I. Sund, M. Sternby, H. Bradbury, K.E. Wareham, N. Riboli, E. Gunter, M. Brennan, P. Duell, E.J. Ferrari, P.
- Abstract
Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1–4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1–2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake. © 2018 IARC/WHO
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- 2018
35. Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort
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Fortner, R.T. Schock, H. Le Cornet, C. Hüsing, A. Vitonis, A.F. Johnson, T.S. Fichorova, R.N. Fashemi, T. Yamamoto, H.S. Tjønneland, A. Hansen, L. Overvad, K. Boutron-Ruault, M.-C. Kvaskoff, M. Severi, G. Boeing, H. Trichopoulou, A. Papatesta, E.-M. La Vecchia, C. Palli, D. Sieri, S. Tumino, R. Sacerdote, C. Mattiello, A. Onland-Moret, N.C. Peeters, P.H. Bueno-de-Mesquita, H.B. Weiderpass, E. Quirós, J.R. Duell, E.J. Sánchez, M.-J. Navarro, C. Ardanaz, E. Larrañaga, N. Nodin, B. Jirström, K. Idahl, A. Lundin, E. Khaw, K.-T. Travis, R.C. Gunter, M. Johansson, M. Dossus, L. Merritt, M.A. Riboli, E. Terry, K.L. Cramer, D.W. Kaaks, R.
- Subjects
endocrine system diseases ,female genital diseases and pregnancy complications - Abstract
CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases. We investigated these objectives using a nested case–control study within the European Prospective Investigation into Cancer and Nutrition cohort (EPIC) including 250 cases diagnosed within 4 years of blood collection and up to four matched controls. Circulating CA125 antigen and antibody levels were quantified using an electrochemiluminescence assay. Adjusted areas under the curve (aAUCs) by 2-year lag-time intervals were calculated using conditional logistic regression calibrated toward the absolute risk estimates from a pre-existing epidemiological risk model as an offset-variable. Anti-CA125 levels alone did not discriminate cases from controls. For cases diagnosed
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- 2018
36. A prospective evaluation of plasma polyphenol levels and colon cancer risk
- Author
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Murphy, N. Achaintre, D. Zamora-Ros, R. Jenab, M. Boutron-Ruault, M.-C. Carbonnel, F. Savoye, I. Kaaks, R. Kühn, T. Boeing, H. Aleksandrova, K. Tjønneland, A. Kyrø, C. Overvad, K. Quirós, J.R. Sánchez, M.-J. Altzibar, J.M. María Huerta, J. Barricarte, A. Khaw, K.-T. Bradbury, K.E. Perez-Cornago, A. Trichopoulou, A. Karakatsani, A. Peppa, E. Palli, D. Grioni, S. Tumino, R. Sacerdote, C. Panico, S. Bueno-de-Mesquita, H.B. Peeters, P.H. Rutegård, M. Johansson, I. Freisling, H. Noh, H. Cross, A.J. Vineis, P. Tsilidis, K. Gunter, M.J. Scalbert, A.
- Abstract
Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (q values ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log 2 -transformed multivariable models, equol (odds ratio [OR] per log 2 -value, 0.86, 95% confidence interval [95% CI] = 0.79–0.93; q value = 0.01) and homovanillic acid (OR per log 2 -value, 1.46, 95% CI = 1.16–1.84; q value = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41–0.91, p trend = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17–2.53, p trend < 0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis. © 2018 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC
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- 2018
37. Prediction of acute myeloid leukaemia risk in healthy individuals
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Abelson, S. Collord, G. Ng, S.W.K. Weissbrod, O. Mendelson Cohen, N. Niemeyer, E. Barda, N. Zuzarte, P.C. Heisler, L. Sundaravadanam, Y. Luben, R. Hayat, S. Wang, T.T. Zhao, Z. Cirlan, I. Pugh, T.J. Soave, D. Ng, K. Latimer, C. Hardy, C. Raine, K. Jones, D. Hoult, D. Britten, A. McPherson, J.D. Johansson, M. Mbabaali, F. Eagles, J. Miller, J.K. Pasternack, D. Timms, L. Krzyzanowski, P. Awadalla, P. Costa, R. Segal, E. Bratman, S.V. Beer, P. Behjati, S. Martincorena, I. Wang, J.C.Y. Bowles, K.M. Quirós, J.R. Karakatsani, A. La Vecchia, C. Trichopoulou, A. Salamanca-Fernández, E. Huerta, J.M. Barricarte, A. Travis, R.C. Tumino, R. Masala, G. Boeing, H. Panico, S. Kaaks, R. Krämer, A. Sieri, S. Riboli, E. Vineis, P. Foll, M. McKay, J. Polidoro, S. Sala, N. Khaw, K.-T. Vermeulen, R. Campbell, P.J. Papaemmanuil, E. Minden, M.D. Tanay, A. Balicer, R.D. Wareham, N.J. Gerstung, M. Dick, J.E. Brennan, P. Vassiliou, G.S. Shlush, L.I.
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hemic and lymphatic diseases ,neoplasms - Abstract
The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow failure 1 . The onset of such de novo AML cases is typically preceded by the accumulation of somatic mutations in preleukaemic haematopoietic stem and progenitor cells (HSPCs) that undergo clonal expansion 2,3 . However, recurrent AML mutations also accumulate in HSPCs during ageing of healthy individuals who do not develop AML, a phenomenon referred to as age-related clonal haematopoiesis (ARCH) 4-8 . Here we use deep sequencing to analyse genes that are recurrently mutated in AML to distinguish between individuals who have a high risk of developing AML and those with benign ARCH. We analysed peripheral blood cells from 95 individuals that were obtained on average 6.3 years before AML diagnosis (pre-AML group), together with 414 unselected age- and gender-matched individuals (control group). Pre-AML cases were distinct from controls and had more mutations per sample, higher variant allele frequencies, indicating greater clonal expansion, and showed enrichment of mutations in specific genes. Genetic parameters were used to derive a model that accurately predicted AML-free survival; this model was validated in an independent cohort of 29 pre-AML cases and 262 controls. Because AML is rare, we also developed an AML predictive model using a large electronic health record database that identified individuals at greater risk. Collectively our findings provide proof-of-concept that it is possible to discriminate ARCH from pre-AML many years before malignant transformation. This could in future enable earlier detection and monitoring, and may help to inform intervention. © 2018 Macmillan Publishers Ltd., part of Springer Nature.
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- 2018
38. Circulating metabolites associated with alcohol intake in the european prospective investigation into cancer and nutrition cohort
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van Roekel, E.H. Trijsburg, L. Assi, N. Carayol, M. Achaintre, D. Murphy, N. Rinaldi, S. Schmidt, J.A. Stepien, M. Kaaks, R. Kühn, T. Boeing, H. Iqbal, K. Palli, D. Krogh, V. Tumino, R. Ricceri, F. Panico, S. Peeters, P.H. Bueno-de-Mesquita, B. Ardanaz, E. Lujan-Barroso, L. Quirós, J.R. Huerta, J.M. Molina-Portillo, E. Dorronsoro, M. Tsilidis, K.K. Riboli, E. Rostgaard-Hansen, A.L. Tjønneland, A. Overvad, K. Weiderpass, E. Boutron-Ruault, M.-C. Severi, G. Trichopoulou, A. Karakatsani, A. Kotanidou, A. Håkansson, A. Malm, J. Weijenberg, M.P. Gunter, M.J. Jenab, M. Johansson, M. Travis, R.C. Scalbert, A. Ferrari, P.
- Abstract
Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTMp180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption withmetabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions. © 2018 by the authors.
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- 2018
39. Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition
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Schmidt, J.A. Fensom, G.K. Rinaldi, S. Scalbert, A. Appleby, P.N. Achaintre, D. Gicquiau, A. Gunter, M.J. Ferrari, P. Kaaks, R. Kühn, T. Floegel, A. Boeing, H. Trichopoulou, A. Lagiou, P. Anifantis, E. Agnoli, C. Palli, D. Trevisan, M. Tumino, R. Bueno-de-Mesquita, H.B. Agudo, A. Larrañaga, N. Redondo-Sánchez, D. Barricarte, A. Huerta, J.M. Quirós, J.R. Wareham, N. Khaw, K.-T. Perez-Cornago, A. Johansson, M. Cross, A.J. Tsilidis, K.K. Riboli, E. Key, T.J. Travis, R.C.
- Abstract
Background: Little is known about how pre-diagnostic metabolites in blood relate to risk of prostate cancer. We aimed to investigate the prospective association between plasma metabolite concentrations and risk of prostate cancer overall, and by time to diagnosis and tumour characteristics, and risk of death from prostate cancer. Methods: In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition, pre-diagnostic plasma concentrations of 122 metabolites (including acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexose and sphingolipids) were measured using targeted mass spectrometry (AbsoluteIDQ p180 Kit) and compared between 1077 prostate cancer cases and 1077 matched controls. Risk of prostate cancer associated with metabolite concentrations was estimated by multi-variable conditional logistic regression, and multiple testing was accounted for by using a false discovery rate controlling procedure. Results: Seven metabolite concentrations, i.e. acylcarnitine C18:1, amino acids citrulline and trans-4-hydroxyproline, glycerophospholipids PC aa C28:1, PC ae C30:0 and PC ae C30:2, and sphingolipid SM (OH) C14:1, were associated with prostate cancer (p < 0.05), but none of the associations were statistically significant after controlling for multiple testing. Citrulline was associated with a decreased risk of prostate cancer (odds ratio (OR1SD) = 0.73; 95% confidence interval (CI) 0.62-0.86; p trend = 0.0002) in the first 5 years of follow-up after taking multiple testing into account, but not after longer follow-up; results for other metabolites did not vary by time to diagnosis. After controlling for multiple testing, 12 glycerophospholipids were inversely associated with advanced stage disease, with risk reduction up to 46% per standard deviation increase in concentration (OR1SD = 0.54; 95% CI 0.40-0.72; p trend = 0.00004 for PC aa C40:3). Death from prostate cancer was associated with higher concentrations of acylcarnitine C3, amino acids methionine and trans-4-hydroxyproline, biogenic amine ADMA, hexose and sphingolipid SM (OH) C14:1 and lower concentration of glycerophospholipid PC aa C42:4. Conclusions: Several metabolites, i.e. C18:1, citrulline, trans-4-hydroxyproline, three glycerophospholipids and SM (OH) C14:1, might be related to prostate cancer. Analyses by time to diagnosis indicated that citrulline may be a marker of subclinical prostate cancer, while other metabolites might be related to aetiology. Several glycerophospholipids were inversely related to advanced stage disease. More prospective data are needed to confirm these associations. © 2017 The Author(s).
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- 2017
40. Added value of serum hormone measurements in risk prediction models for breast cancer for women not using exogenous hormones: Results from the EPIC cohort
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Hüsing, A. Fortner, R.T. Kühn, T. Overvad, K. Tjønneland, A. Olsen, A. Boutron-Ruault, M.-C. Severi, G. Fournier, A. Boeing, H. Trichopoulou, A. Benetou, V. Orfanos, P. Masala, G. Pala, V. Tumino, R. Fasanelli, F. Panico, S. De Mesquita, H.B.B. Peeters, P.H. Van Gills, C.H. Quirós, J.R. Agudo, A. Sánchez, M.-J. Chirlaque, M.-D. Barricarte, A. Amiano, P. Khaw, K.-T. Travis, R.C. Dossus, L. Li, K. Ferrari, P. Merritt, M.A. Tzoulaki, I. Riboli, E. Kaaks, R.
- Abstract
Purpose: Circulating hormone concentrations are associated with breast cancer risk, with well-established associations for postmenopausal women. Biomarkers may represent minimally invasive measures to improve risk prediction models. Experimental Design: We evaluated improvements in discrimination gained by adding serum biomarker concentrations to risk estimates derived from risk prediction models developed by Gail and colleagues and Pfeiffer and colleagues using a nested case–control study within the EPIC cohort, including 1,217 breast cancer cases and 1,976 matched controls. Participants were pre- or postmenopausal at blood collection. Circulating sex steroids, prolactin, insulin-like growth factor (IGF) I, IGF-binding protein 3, and sex hormone–binding globulin (SHBG) were evaluated using backward elimination separately in women pre- and postmenopausal at blood collection. Improvement in discrimination was evaluated as the change in concordance statistic (C-statistic) from a modified Gail or Pfeiffer risk score alone versus models, including the biomarkers and risk score. Internal validation with bootstrapping (1,000-fold) was used to adjust for overfitting. Results: Among women postmenopausal at blood collection, estradiol, testosterone, and SHBG were selected into the prediction models. For breast cancer overall, model discrimination after including biomarkers was 5.3 percentage points higher than the modified Gail model alone, and 3.4 percentage points higher than the Pfeiffer model alone, after accounting for overfitting. Discrimination was more markedly improved for estrogen receptor–positive disease (percentage point change in C-statistic: 7.2, Gail; 4.8, Pfeiffer). We observed no improvement in discrimination among women premenopausal at blood collection. Conclusions: Integration of hormone measurements in clinical risk prediction models may represent a strategy to improve breast cancer risk stratification. ©2017 AACR.
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- 2017
41. Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort
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Fortner, R.T. Vitonis, A.F. Schock, H. Hüsing, A. Johnson, T. Fichorova, R.N. Fashemi, T. Yamamoto, H.S. Tjønneland, A. Hansen, L. Overvad, K. Boutron-Ruault, M.-C. Kvaskoff, M. Severi, G. Boeing, H. Trichopoulou, A. Benetou, V. La Vecchia, C. Palli, D. Sieri, S. Tumino, R. Matullo, G. Mattiello, A. Onland-Moret, N.C. Peeters, P.H. Weiderpass, E. Gram, I.T. Jareid, M. Quirós, J.R. Duell, E.J. Sánchez, M.-J. Chirlaque, M.D. Ardanaz, E. Larrañaga, N. Nodin, B. Brändstedt, J. Idahl, A. Khaw, K.-T. Allen, N. Gunter, M. Johansson, M. Dossus, L. Merritt, M.A. Riboli, E. Cramer, D.W. Kaaks, R. Terry, K.L.
- Abstract
Background: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. Methods: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression. Results: CA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women (p ≤ 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (ptrend ≤ 0.02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p < 0.01). CA15.3 concentrations were higher among heavier women and in former smokers (p ≤ 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause (≤ 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination. Conclusions: This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors. © 2017 The Author(s).
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- 2017
42. Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort
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Matejcic, M. de Batlle, J. Ricci, C. Biessy, C. Perrier, F. Huybrechts, I. Weiderpass, E. Boutron-Ruault, M.C. Cadeau, C. His, M. Cox, D.G. Boeing, H. Fortner, R.T. Kaaks, R. Lagiou, P. Trichopoulou, A. Benetou, V. Tumino, R. Panico, S. Sieri, S. Palli, D. Ricceri, F. Bueno-de-Mesquita, H.B. Skeie, G. Amiano, P. Sánchez, M.J. Chirlaque, M.D. Barricarte, A. Quirós, J.R. Buckland, G. van Gils, C.H. Peeters, P.H. Key, T.J. Riboli, E. Gylling, B. Zeleniuch-Jacquotte, A. Gunter, M.J. Romieu, I. Chajès, V.
- Abstract
Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4-Q1 = 1.26; 95% CI 1.00–1.58; Ptrend = 0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1 = 1.29; 95% CI 1.02–1.62; Ptrend = 0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation. © 2016 UICC
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- 2017
43. Physical activity, mediating factors and risk of colon cancer: Insights into adiposity and circulating biomarkers from the EPIC cohort
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Aleksandrova, K. Jenab, M. Leitzmann, M. Bueno-de-Mesquita, B. Kaaks, R. Trichopoulou, A. Bamia, C. Lagiou, P. Rinaldi, S. Freisling, H. Carayol, M. Pischon, T. Drogan, D. Weiderpass, E. Jakszyn, P. Overvad, K. Dahm, C.C. Tjønneland, A. Bouton-Ruault, M.-C. Kühn, T. Peppa, E. Valanou, E. La Vecchia, C. Palli, D. Panico, S. Sacerdote, C. Agnoli, C. Tumino, R. May, A. van Vulpen, J. Borch, K.B. Oyeyemi, S.O. Quirós, J.R. Bonet, C. Sánchez, M.-J. Dorronsoro, M. Navarro, C. Barricarte, A. van Guelpen, B. Wennberg, P. Key, T.J. Khaw, K.-T. Wareham, N. Assi, N. Ward, H.A. Aune, D. Riboli, E. Boeing, H.
- Abstract
Background: There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer. Methods: We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline. Results: High physical activity was associated with a lower risk of colon cancer: relative risk ≥91 MET-h/week vs < 91 MET-h/week=0.75 [95% confidence interval (CI): 0.57 to 0.96]. In mediation analyses, this association was accounted for by waist circumference: proportion explained effect (PEE)=17%; CI: 4% to 52%; and the biomarkers soluble leptin receptor (sOB-R): PEE=15%; 95% CI: 1% to 50% and 5-hydroxyvitamin D (25[OH]D): PEE=30%; 95% CI: 12% to 88%. In combination, these factors explained 45% (95% CI: 20% to 125%) of the association. Beyond waist circumference, sOB-R and 25[OH]D additionally explained 10% (95% CI: 1%; 56%) and 23% (95% CI: 6%; 111%) of the association, respectively. Conclusions: Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention. © The Author 2017.
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- 2017
44. Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort
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Matejcic, M., primary, Lesueur, F., additional, Biessy, C., additional, Renault, A.L., additional, Mebirouk, N., additional, Yammine, S., additional, Keski‐Rahkonen, P., additional, Li, K., additional, Hémon, B., additional, Weiderpass, E., additional, Rebours, V., additional, Boutron‐Ruault, M.C., additional, Carbonnel, F., additional, Kaaks, R., additional, Katzke, V., additional, Kuhn, T., additional, Boeing, H., additional, Trichopoulou, A., additional, Palli, D., additional, Agnoli, C., additional, Panico, S., additional, Tumino, R., additional, Sacerdote, C., additional, Quirós, J.R., additional, Duell, E.J., additional, Porta, M., additional, Sánchez, M.J., additional, Chirlaque, M.D., additional, Barricarte, A., additional, Amiano, P., additional, Ye, W., additional, Peeters, P.H., additional, Khaw, K.T., additional, Perez‐Cornago, A., additional, Key, T.J., additional, Bueno‐de‐Mesquita, H.B., additional, Riboli, E., additional, Vineis, P., additional, Romieu, I., additional, Gunter, M.J., additional, and Chajès, V., additional
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- 2018
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45. Erratum to “The histology of ovarian cancer: Worldwide distribution and implications for international survival comparisons (CONCORD-2)” [Gynecol. Oncol. 144 (2017) 405–413]
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Matz, Melissa, primary, Coleman, Michel P., additional, Sant, Milena, additional, Chirlaque, Maria Dolores, additional, Visser, Otto, additional, Gore, Martin, additional, Allemani, Claudia, additional, Bouzbid, S., additional, Hamdi-Chérif, M., additional, Zaidi, Z., additional, Bah, E., additional, Swaminathan, R., additional, Nortje, S.H., additional, El Mistiri, M.M., additional, Bayo, S., additional, Malle, B., additional, Manraj, S.S., additional, Sewpaul-Sungkur, R., additional, Fabowale, A., additional, Ogunbiyi, O.J., additional, Bradshaw, D., additional, Somdyala, N.I.M., additional, Stefan, D.C., additional, Abdel-Rahman, M., additional, Jaidane, L., additional, Mokni, M., additional, Kumcher, I., additional, Moreno, F., additional, González, M.S., additional, Laura, E.A., additional, Espinola, S.B., additional, Calabrano, G.H., additional, Carballo Quintero, B., additional, Fita, R., additional, Garcilazo, D.A., additional, Giacciani, P.L., additional, Diumenjo, M.C., additional, Laspada, W.D., additional, Green, M.A., additional, Lanza, M.F., additional, Ibañez, S.G., additional, Lima, C.A., additional, Lobo de Oliveira, E., additional, Daniel, C., additional, Scandiuzzi, C., additional, De Souza, P.C.F., additional, Melo, C.D., additional, Del Pino, K., additional, Laporte, C., additional, Curado, M.P., additional, de Oliveira, J.C., additional, Veneziano, C.L.A., additional, Veneziano, D.B., additional, Latorre, M.R.D.O., additional, Tanaka, L.F., additional, Azevedo e Silva, G., additional, Galaz, J.C., additional, Moya, J.A., additional, Herrmann, D.A., additional, Vargas, S., additional, Herrera, V.M., additional, Uribe, C.J., additional, Bravo, L.E., additional, Arias-Ortiz, N.E., additional, Jurado, D.M., additional, Yépez, M.C., additional, Galán, Y.H., additional, Torres, P., additional, Martínez-Reyes, F., additional, Pérez-Meza, M.L., additional, Jaramillo, L., additional, Quinto, R., additional, Cueva, P., additional, Yépez, J.G., additional, Torres-Cintrón, C.R., additional, Tortolero-Luna, G., additional, Alonso, R., additional, Barrios, E., additional, Nikiforuk, C., additional, Shack, L., additional, Coldman, A.J., additional, Woods, R.R., additional, Noonan, G., additional, Turner, D., additional, Kumar, E., additional, Zhang, B., additional, McCrate, F.R., additional, Ryan, S., additional, Hannah, H., additional, Dewar, R.A.D., additional, MacIntyre, M., additional, Lalany, A., additional, Ruta, M., additional, Marrett, L., additional, Nishri, D.E., additional, McClure, C., additional, Vriends, K.A., additional, Bertrand, C., additional, Louchini, R., additional, Robb, K.I., additional, Stuart-Panko, H., additional, Demers, S., additional, Wright, S., additional, George, J.T., additional, Shen, X., additional, Brockhouse, J.T., additional, O'Brien, D.K., additional, Ward, K.C., additional, Almon, L., additional, Bates, J., additional, Rycroft, R., additional, Mueller, L., additional, Phillips, C., additional, Brown, H., additional, Cromartie, B., additional, Schwartz, A.G., additional, Vigneau, F., additional, MacKinnon, J.A., additional, Wohler, B., additional, Bayakly, A.R., additional, Clarke, C.A., additional, Glaser, S.L., additional, West, D., additional, Green, M.D., additional, Hernandez, B.Y., additional, Johnson, C.J., additional, Jozwik, D., additional, Charlton, M.E., additional, Lynch, C.F., additional, Huang, B., additional, Tucker, T.C., additional, Deapen, D., additional, Liu, L., additional, Hsieh, M.C., additional, Wu, X.C., additional, Stern, K., additional, Gershman, S.T., additional, Knowlton, R.C., additional, Alverson, J., additional, Copeland, G.E., additional, Rogers, D.B., additional, Lemons, D., additional, Williamson, L.L., additional, Hood, M., additional, Hosain, G.M., additional, Rees, J.R., additional, Pawlish, K.S., additional, Stroup, A., additional, Key, C., additional, Wiggins, C., additional, Kahn, A.R., additional, Schymura, M.J., additional, Leung, G., additional, Rao, C., additional, Giljahn, L., additional, Warther, B., additional, Pate, A., additional, Patil, M., additional, Schubert, S.S., additional, Rubertone, J.J., additional, Slack, S.J., additional, Fulton, J.P., additional, Rousseau, D.L., additional, Janes, T.A., additional, Schwartz, S.M., additional, Bolick, S.W., additional, Hurley, D.M., additional, Richards, J., additional, Whiteside, M.A., additional, Nogueira, L.M., additional, Herget, K., additional, Sweeney, C., additional, Martin, J., additional, Wang, S., additional, Harrelson, D.G., additional, Keitheri Cheteri, M.B., additional, Farley, S., additional, Hudson, A.G., additional, Borchers, R., additional, Stephenson, L., additional, Espinoza, J.R., additional, Weir, H.K., additional, Edwards, B.K., additional, Wang, N., additional, Yang, L., additional, Chen, J.S., additional, Song, G.H., additional, Gu, X.P., additional, Zhang, P., additional, Ge, H.M., additional, Zhao, D.L., additional, Zhang, J.H., additional, Zhu, F.D., additional, Tang, J.G., additional, Shen, Y., additional, Wang, J., additional, Li, Q.L., additional, Yang, X.P., additional, Dong, J., additional, Li, W., additional, Cheng, L.P., additional, Chen, J.G., additional, Huang, Q.H., additional, Huang, S.Q., additional, Guo, G.P., additional, Wei, K., additional, Chen, W.Q., additional, Zeng, H., additional, Demetriou, A.V., additional, Pavlou, P., additional, Mang, W.K., additional, Ngan, K.C., additional, Kataki, A.C., additional, Krishnatreya, M., additional, Jayalekshmi, P.A., additional, Sebastian, P., additional, Sapkota, S.D., additional, Verma, Y., additional, Nandakumar, A., additional, Suzanna, E., additional, Keinan-Boker, L., additional, Silverman, B.G., additional, Ito, H., additional, Nakagawa, H., additional, Hattori, M., additional, Kaizaki, Y., additional, Sugiyama, H., additional, Utada, M., additional, Katayama, K., additional, Narimatsu, H., additional, Kanemura, S., additional, Koike, T., additional, Miyashiro, I., additional, Yoshii, M., additional, Oki, I., additional, Shibata, A., additional, Matsuda, T., additional, Nimri, O., additional, Ab Manan, A., additional, Bhoo-Pathy, N., additional, Tuvshingerel, S., additional, Chimedsuren, O., additional, Al Khater, A.H.M., additional, Al-Eid, H., additional, Jung, K.W., additional, Won, Y.J., additional, Chiang, C.J., additional, Lai, M.S., additional, Suwanrungruang, K., additional, Wiangnon, S., additional, Daoprasert, K., additional, Pongnikorn, D., additional, Geater, S.L., additional, Sriplung, H., additional, Eser, S., additional, Yakut, C.I., additional, Hackl, M., additional, Mühlböck, H., additional, Oberaigner, W., additional, Zborovskaya, A.A., additional, Aleinikova, O.V., additional, Henau, K., additional, Van Eycken, L., additional, Dimitrova, N., additional, Valerianova, Z., additional, Šekerija, M., additional, Zvolský, M., additional, Engholm, G., additional, Storm, H., additional, Innos, K., additional, Mägi, M., additional, Malila, N., additional, Seppä, K., additional, Jégu, J., additional, Velten, M., additional, Cornet, E., additional, Troussard, X., additional, Bouvier, A.M., additional, Faivre, J., additional, Guizard, A.V., additional, Bouvier, V., additional, Launoy, G., additional, Arveux, P., additional, Maynadié, M., additional, Mounier, M., additional, Fournier, E., additional, Woronoff, A.S., additional, Daoulas, M., additional, Clavel, J., additional, Le Guyader-Peyrou, S., additional, Monnereau, A., additional, Trétarre, B., additional, Colonna, M., additional, Cowppli-Bony, A., additional, Molinié, F., additional, Bara, S., additional, Degré, D., additional, Ganry, O., additional, Lapôtre-Ledoux, B., additional, Grosclaude, P., additional, Estève, J., additional, Bray, F., additional, Piñeros, M., additional, Sassi, F., additional, Stabenow, R., additional, Eberle, A., additional, Erb, C., additional, Nennecke, A., additional, Kieschke, J., additional, Sirri, E., additional, Kajueter, H., additional, Emrich, K., additional, Zeissig, S.R., additional, Holleczek, B., additional, Eisemann, N., additional, Katalinic, A., additional, Brenner, H., additional, Asquez, R.A., additional, Kumar, V., additional, Ólafsdóttir, E.J., additional, Tryggvadóttir, L., additional, Comber, H., additional, Walsh, P.M., additional, Sundseth, H., additional, Devigili, E., additional, Mazzoleni, G., additional, Giacomin, A., additional, Bella, F., additional, Castaing, M., additional, Sutera, A., additional, Gola, G., additional, Ferretti, S., additional, Serraino, D., additional, Zucchetto, A., additional, Lillini, R., additional, Vercelli, M., additional, Busco, S., additional, Pannozzo, F., additional, Vitarelli, S., additional, Ricci, P., additional, Pascucci, C., additional, Autelitano, M., additional, Cirilli, C., additional, Federico, M., additional, Fusco, M., additional, Vitale, M.F., additional, Usala, M., additional, Cusimano, R., additional, Mazzucco, W., additional, Michiara, M., additional, Sgargi, P., additional, Maule, M.M., additional, Sacerdote, C., additional, Tumino, R., additional, Di Felice, E., additional, Vicentini, M., additional, Falcini, F., additional, Cremone, L., additional, Budroni, M., additional, Cesaraccio, R., additional, Contrino, M.L., additional, Tisano, F., additional, Fanetti, A.C., additional, Maspero, S., additional, Candela, G., additional, Scuderi, T., additional, Gentilini, M.A., additional, Piffer, S., additional, Rosso, S., additional, Sacchetto, L., additional, Caldarella, A., additional, La Rosa, F., additional, Stracci, F., additional, Contiero, P., additional, Tagliabue, G., additional, Dei Tos, A.P., additional, Zorzi, M., additional, Zanetti, R., additional, Baili, P., additional, Berrino, F., additional, Gatta, G., additional, Sant, M., additional, Capocaccia, R., additional, De Angelis, R., additional, Liepina, E., additional, Maurina, A., additional, Smailyte, G., additional, Agius, D., additional, Calleja, N., additional, Siesling, S., additional, Visser, O., additional, Larønningen, S., additional, Møller, B., additional, Dyzmann-Sroka, A., additional, Trojanowski, M., additional, Góźdż, S., additional, Mężyk, R., additional, Grądalska-Lampart, M., additional, Radziszewska, A.U., additional, Didkowska, J.A., additional, Wojciechowska, U., additional, Błaszczyk, J., additional, Kępska, K., additional, Bielska-Lasota, M., additional, Kwiatkowska, K., additional, Forjaz, G., additional, Rego, R.A., additional, Bastos, J., additional, Silva, M.A., additional, Antunes, L., additional, Bento, M.J., additional, Mayer-da-Silva, A., additional, Miranda, A., additional, Coza, D., additional, Todescu, A.I., additional, Valkov, M.Y., additional, Adamcik, J., additional, Safaei Diba, C., additional, Primic-Žakelj, M., additional, Žagar, T., additional, Stare, J., additional, Almar, E., additional, Mateos, A., additional, Quirós, J.R., additional, Bidaurrazaga, J., additional, Larrañaga, N., additional, Díaz García, J.M., additional, Marcos, A.I., additional, Marcos-Gragera, R., additional, Vilardell Gil, M.L., additional, Molina, E., additional, Sánchez, M.J., additional, Franch Sureda, P., additional, Ramos Montserrat, M., additional, Chirlaque, M.D., additional, Navarro, C., additional, Ardanaz, E.E., additional, Moreno-Iribas, C.C., additional, Fernández-Delgado, R., additional, Peris-Bonet, R., additional, Galceran, J., additional, Khan, S., additional, Lambe, M., additional, Camey, B., additional, Bouchardy, C., additional, Usel, M., additional, Ess, S.M., additional, Herrmann, C., additional, Bulliard, J.L., additional, Maspoli-Conconi, M., additional, Frick, H., additional, Kuehni, C.E., additional, Schindler, M., additional, Bordoni, A., additional, Spitale, A., additional, Chiolero, A., additional, Konzelmann, I., additional, Dehler, S.I., additional, Matthes, K.L., additional, Rashbass, J., additional, Stiller, C.A., additional, Fitzpatrick, D., additional, Gavin, A., additional, Bannon, F., additional, Black, R.J., additional, Brewster, D.H., additional, Huws, D.W., additional, White, C., additional, Finan, P., additional, Allemani, C., additional, Bonaventure, A., additional, Carreira, H., additional, Coleman, M.P., additional, Di Carlo, V., additional, Harewood, R., additional, Liu, K., additional, Matz, M., additional, Montel, L., additional, Nikšić, M., additional, Rachet, B., additional, Sanz, N., additional, Spika, D., additional, Stephens, R., additional, Peake, M., additional, Chalker, E., additional, Newman, L., additional, Baker, D., additional, Soeberg, M.J., additional, Aitken, J., additional, Scott, C., additional, Stokes, B.C., additional, Venn, A., additional, Farrugia, H., additional, Giles, G.G., additional, Threlfall, T., additional, Currow, D., additional, You, H., additional, Hendrix, J., additional, and Lewis, C., additional
- Published
- 2017
- Full Text
- View/download PDF
46. Erratum to “Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)” [Gynecol. Oncol. 144 (2017) 396–404]
- Author
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Matz, Melissa, primary, Coleman, Michel P., additional, Carreira, Helena, additional, Salmerón, Diego, additional, Chirlaque, Maria Dolores, additional, Allemani, Claudia, additional, Bouzbid, S., additional, Hamdi-Chérif, M., additional, Zaidi, Z., additional, Bah, E., additional, Swaminathan, R., additional, Nortje, S.H., additional, El Mistiri, M.M., additional, Bayo, S., additional, Malle, B., additional, Manraj, S.S., additional, Sewpaul-Sungkur, R., additional, Fabowale, A., additional, Ogunbiyi, O.J., additional, Bradshaw, D., additional, Somdyala, N.I.M., additional, Stefan, D.C., additional, Abdel-Rahman, M., additional, Jaidane, L., additional, Mokni, M., additional, Kumcher, I., additional, Moreno, F., additional, González, M.S., additional, Laura, E.A., additional, Espinola, S.B., additional, Calabrano, G.H., additional, Carballo Quintero, B., additional, Fita, R., additional, Garcilazo, D.A., additional, Giacciani, P.L., additional, Diumenjo, M.C., additional, Laspada, W.D., additional, Green, M.A., additional, Lanza, M.F., additional, Ibañez, S.G., additional, Lima, C.A., additional, Lobo de Oliveira, E., additional, Daniel, C., additional, Scandiuzzi, C., additional, De Souza, P.C.F., additional, Melo, C.D., additional, Del Pino, K., additional, Laporte, C., additional, Curado, M.P., additional, de Oliveira, J.C., additional, Veneziano, C.L.A., additional, Veneziano, D.B., additional, Latorre, M.R.D.O., additional, Tanaka, L.F., additional, Azevedo e Silva, G., additional, Galaz, J.C., additional, Moya, J.A., additional, Herrmann, D.A., additional, Vargas, S., additional, Herrera, V.M., additional, Uribe, C.J., additional, Bravo, L.E., additional, Arias-Ortiz, N.E., additional, Jurado, D.M., additional, Yépez, M.C., additional, Galán, Y.H., additional, Torres, P., additional, Martínez-Reyes, F., additional, Pérez-Meza, M.L., additional, Jaramillo, L., additional, Quinto, R., additional, Cueva, P., additional, Yépez, J.G., additional, Torres-Cintrón, C.R., additional, Tortolero-Luna, G., additional, Alonso, R., additional, Barrios, E., additional, Nikiforuk, C., additional, Shack, L., additional, Coldman, A.J., additional, Woods, R.R., additional, Noonan, G., additional, Turner, D., additional, Kumar, E., additional, Zhang, B., additional, McCrate, F.R., additional, Ryan, S., additional, Hannah, H., additional, Dewar, R.A.D., additional, MacIntyre, M., additional, Lalany, A., additional, Ruta, M., additional, Marrett, L., additional, Nishri, D.E., additional, McClure, C., additional, Vriends, K.A., additional, Bertrand, C., additional, Louchini, R., additional, Robb, K.I., additional, Stuart-Panko, H., additional, Demers, S., additional, Wright, S., additional, George, J.T., additional, Shen, X., additional, Brockhouse, J.T., additional, O'Brien, D.K., additional, Ward, K.C., additional, Almon, L., additional, Bates, J., additional, Rycroft, R., additional, Mueller, L., additional, Phillips, C., additional, Brown, H., additional, Cromartie, B., additional, Schwartz, A.G., additional, Vigneau, F., additional, MacKinnon, J.A., additional, Wohler, B., additional, Bayakly, A.R., additional, Clarke, C.A., additional, Glaser, S.L., additional, West, D., additional, Green, M.D., additional, Hernandez, B.Y., additional, Johnson, C.J., additional, Jozwik, D., additional, Charlton, M.E., additional, Lynch, C.F., additional, Huang, B., additional, Tucker, T.C., additional, Deapen, D., additional, Liu, L., additional, Hsieh, M.C., additional, Wu, X.C., additional, Stern, K., additional, Gershman, S.T., additional, Knowlton, R.C., additional, Alverson, J., additional, Copeland, G.E., additional, Rogers, D.B., additional, Lemons, D., additional, Williamson, L.L., additional, Hood, M., additional, Hosain, G.M., additional, Rees, J.R., additional, Pawlish, K.S., additional, Stroup, A., additional, Key, C., additional, Wiggins, C., additional, Kahn, A.R., additional, Schymura, M.J., additional, Leung, G., additional, Rao, C., additional, Giljahn, L., additional, Warther, B., additional, Pate, A., additional, Patil, M., additional, Schubert, S.S., additional, Rubertone, J.J., additional, Slack, S.J., additional, Fulton, J.P., additional, Rousseau, D.L., additional, Janes, T.A., additional, Schwartz, S.M., additional, Bolick, S.W., additional, Hurley, D.M., additional, Richards, J., additional, Whiteside, M.A., additional, Nogueira, L.M., additional, Herget, K., additional, Sweeney, C., additional, Martin, J., additional, Wang, S., additional, Harrelson, D.G., additional, Keitheri Cheteri, M.B., additional, Farley, S., additional, Hudson, A.G., additional, Borchers, R., additional, Stephenson, L., additional, Espinoza, J.R., additional, Weir, H.K., additional, Edwards, B.K., additional, Wang, N., additional, Yang, L., additional, Chen, J.S., additional, Song, G.H., additional, Gu, X.P., additional, Zhang, P., additional, Ge, H.M., additional, Zhao, D.L., additional, Zhang, J.H., additional, Zhu, F.D., additional, Tang, J.G., additional, Shen, Y., additional, Wang, J., additional, Li, Q.L., additional, Yang, X.P., additional, Dong, J., additional, Li, W., additional, Cheng, L.P., additional, Chen, J.G., additional, Huang, Q.H., additional, Huang, S.Q., additional, Guo, G.P., additional, Wei, K., additional, Chen, W.Q., additional, Zeng, H., additional, Demetriou, A.V., additional, Pavlou, P., additional, Mang, W.K., additional, Ngan, K.C., additional, Kataki, A.C., additional, Krishnatreya, M., additional, Jayalekshmi, P.A., additional, Sebastian, P., additional, Sapkota, S.D., additional, Verma, Y., additional, Nandakumar, A., additional, Suzanna, E., additional, Keinan-Boker, L., additional, Silverman, B.G., additional, Ito, H., additional, Nakagawa, H., additional, Hattori, M., additional, Kaizaki, Y., additional, Sugiyama, H., additional, Utada, M., additional, Katayama, K., additional, Narimatsu, H., additional, Kanemura, S., additional, Koike, T., additional, Miyashiro, I., additional, Yoshii, M., additional, Oki, I., additional, Shibata, A., additional, Matsuda, T., additional, Nimri, O., additional, Ab Manan, A., additional, Bhoo-Pathy, N., additional, Tuvshingerel, S., additional, Chimedsuren, O., additional, Al Khater, A.H.M., additional, Al-Eid, H., additional, Jung, K.W., additional, Won, Y.J., additional, Chiang, C.J., additional, Lai, M.S., additional, Suwanrungruang, K., additional, Wiangnon, S., additional, Daoprasert, K., additional, Pongnikorn, D., additional, Geater, S.L., additional, Sriplung, H., additional, Eser, S., additional, Yakut, C.I., additional, Hackl, M., additional, Mühlböck, H., additional, Oberaigner, W., additional, Zborovskaya, A.A., additional, Aleinikova, O.V., additional, Henau, K., additional, Van Eycken, L., additional, Dimitrova, N., additional, Valerianova, Z., additional, Šekerija, M., additional, Zvolský, M., additional, Engholm, G., additional, Storm, H., additional, Innos, K., additional, Mägi, M., additional, Malila, N., additional, Seppä, K., additional, Jégu, J., additional, Velten, M., additional, Cornet, E., additional, Troussard, X., additional, Bouvier, A.M., additional, Faivre, J., additional, Guizard, A.V., additional, Bouvier, V., additional, Launoy, G., additional, Arveux, P., additional, Maynadié, M., additional, Mounier, M., additional, Fournier, E., additional, Woronoff, A.S., additional, Daoulas, M., additional, Clavel, J., additional, Le Guyader-Peyrou, S., additional, Monnereau, A., additional, Trétarre, B., additional, Colonna, M., additional, Cowppli-Bony, A., additional, Molinié, F., additional, Bara, S., additional, Degré, D., additional, Ganry, O., additional, Lapôtre-Ledoux, B., additional, Grosclaude, P., additional, Estève, J., additional, Bray, F., additional, Piñeros, M., additional, Sassi, F., additional, Stabenow, R., additional, Eberle, A., additional, Erb, C., additional, Nennecke, A., additional, Kieschke, J., additional, Sirri, E., additional, Kajueter, H., additional, Emrich, K., additional, Zeissig, S.R., additional, Holleczek, B., additional, Eisemann, N., additional, Katalinic, A., additional, Brenner, H., additional, Asquez, R.A., additional, Kumar, V., additional, Ólafsdóttir, E.J., additional, Tryggvadóttir, L., additional, Comber, H., additional, Walsh, P.M., additional, Sundseth, H., additional, Devigili, E., additional, Mazzoleni, G., additional, Giacomin, A., additional, Bella, F., additional, Castaing, M., additional, Sutera, A., additional, Gola, G., additional, Ferretti, S., additional, Serraino, D., additional, Zucchetto, A., additional, Lillini, R., additional, Vercelli, M., additional, Busco, S., additional, Pannozzo, F., additional, Vitarelli, S., additional, Ricci, P., additional, Pascucci, C., additional, Autelitano, M., additional, Cirilli, C., additional, Federico, M., additional, Fusco, M., additional, Vitale, M.F., additional, Usala, M., additional, Cusimano, R., additional, Mazzucco, W., additional, Michiara, M., additional, Sgargi, P., additional, Maule, M.M., additional, Sacerdote, C., additional, Tumino, R., additional, Di Felice, E., additional, Vicentini, M., additional, Falcini, F., additional, Cremone, L., additional, Budroni, M., additional, Cesaraccio, R., additional, Contrino, M.L., additional, Tisano, F., additional, Fanetti, A.C., additional, Maspero, S., additional, Candela, G., additional, Scuderi, T., additional, Gentilini, M.A., additional, Piffer, S., additional, Rosso, S., additional, Sacchetto, L., additional, Caldarella, A., additional, La Rosa, F., additional, Stracci, F., additional, Contiero, P., additional, Tagliabue, G., additional, Dei Tos, A.P., additional, Zorzi, M., additional, Zanetti, R., additional, Baili, P., additional, Berrino, F., additional, Gatta, G., additional, Sant, M., additional, Capocaccia, R., additional, De Angelis, R., additional, Liepina, E., additional, Maurina, A., additional, Smailyte, G., additional, Agius, D., additional, Calleja, N., additional, Siesling, S., additional, Visser, O., additional, Larønningen, S., additional, Møller, B., additional, Dyzmann-Sroka, A., additional, Trojanowski, M., additional, Góźdż, S., additional, Mężyk, R., additional, Grądalska-Lampart, M., additional, Radziszewska, A.U., additional, Didkowska, J.A., additional, Wojciechowska, U., additional, Błaszczyk, J., additional, Kępska, K., additional, Bielska-Lasota, M., additional, Kwiatkowska, K., additional, Forjaz, G., additional, Rego, R.A., additional, Bastos, J., additional, Silva, M.A., additional, Antunes, L., additional, Bento, M.J., additional, Mayer-da-Silva, A., additional, Miranda, A., additional, Coza, D., additional, Todescu, A.I., additional, Valkov, M.Y., additional, Adamcik, J., additional, Safaei Diba, C., additional, Primic-Žakelj, M., additional, Žagar, T., additional, Stare, J., additional, Almar, E., additional, Mateos, A., additional, Quirós, J.R., additional, Bidaurrazaga, J., additional, Larrañaga, N., additional, Díaz García, J.M., additional, Marcos, A.I., additional, Marcos-Gragera, R., additional, Vilardell Gil, M.L., additional, Molina, E., additional, Sánchez, M.J., additional, Franch Sureda, P., additional, Ramos Montserrat, M., additional, Chirlaque, M.D., additional, Navarro, C., additional, Ardanaz, E.E., additional, Moreno-Iribas, C.C., additional, Fernández-Delgado, R., additional, Peris-Bonet, R., additional, Galceran, J., additional, Khan, S., additional, Lambe, M., additional, Camey, B., additional, Bouchardy, C., additional, Usel, M., additional, Ess, S.M., additional, Herrmann, C., additional, Bulliard, J.L., additional, Maspoli-Conconi, M., additional, Frick, H., additional, Kuehni, C.E., additional, Schindler, M., additional, Bordoni, A., additional, Spitale, A., additional, Chiolero, A., additional, Konzelmann, I., additional, Dehler, S.I., additional, Matthes, K.L., additional, Rashbass, J., additional, Stiller, C.A., additional, Fitzpatrick, D., additional, Gavin, A., additional, Bannon, F., additional, Black, R.J., additional, Brewster, D.H., additional, Huws, D.W., additional, White, C., additional, Finan, P., additional, Allemani, C., additional, Bonaventure, A., additional, Carreira, H., additional, Coleman, M.P., additional, Di Carlo, V., additional, Harewood, R., additional, Liu, K., additional, Matz, M., additional, Montel, L., additional, Nikšić, M., additional, Rachet, B., additional, Sanz, N., additional, Spika, D., additional, Stephens, R., additional, Peake, M., additional, Chalker, E., additional, Newman, L., additional, Baker, D., additional, Soeberg, M.J., additional, Aitken, J., additional, Scott, C., additional, Stokes, B.C., additional, Venn, A., additional, Farrugia, H., additional, Giles, G.G., additional, Threlfall, T., additional, Currow, D., additional, You, H., additional, Hendrix, J., additional, and Lewis, C., additional
- Published
- 2017
- Full Text
- View/download PDF
47. Worldwide comparison of survival from childhood leukaemia for 1995-2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries.
- Author
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CONCORD Working Group, Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S.H., El Mistiri, M.M., Bayo, S., Malle, B., Manraj, S.S., Sewpaul-Sungkur, R., Ogunbiyi, O.J., Bradshaw, D., Somdyala, N., Stefan, D.C., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M.S., Laura, E.A., Espinola, S.B., Calabrano, G.H., Carballo Quintero, B., Fita, R., Garcilazo, D.A., Giacciani, P.L., Diumenjo, M.C., Laspada, W.D., Green, M.A., Lanza, M.F., Ibañez, S.G., Lima, C.A., de Oliveira, E.L., Daniel, C., Scandiuzzi, C., De Souza, P., Melo, C.D., Del Pino, K., Laporte, C., Curado, M.P., de Oliveira, J.C., Veneziano, C., Veneziano, D.B., Azevedo E Silva, G., Galaz, J.C., Moya, J.A., Herrmann, D.A., Vargas, S., Herrera, V.M., Uribe, C.J., Bravo, L.E., Arias-Ortiz, N.E., Jurado, D.M., Yépez, M.C., Galán, Y.H., Torres, P., Martínez-Reyes, F., Pérez-Meza, M.L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J.G., Torres-Cintrón, C.R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A.J., Woods, R.R., Noonan, G., Turner, D., Kumar, E., Zhang, B., McCrate, F.R., Ryan, S., Hannah, H., Dewar, R., MacIntyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D.E., McClure, C., Vriends, K.A., Bertrand, C., Louchini, R., Robb, K.I., Stuart-Panko, H., Demers, S., Wright, S., George, J.T., Shen, X., Brockhouse, J.T., O'Brien, D.K., Ward, K.C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A.G., Vigneau, F., MacKinnon, J.A., Wohler, B., Bayakly, A.R., Clarke, C.A., Glaser, S.L., West, D., Green, M.D., Hernandez, B.Y., Johnson, C.J., Jozwik, D., Charlton, M.E., Lynch, C.F., Huang, B., Tucker, T.C., Deapen, D., Liu, L., Hsieh, M.C., Wu, X.C., Stern, K., Gershman, S.T., Knowlton, R.C., Alverson, J., Copeland, G.E., Rogers, D.B., Lemons, D., Williamson, L.L., Hood, M., Hosain, G.M., Rees, J.R., Pawlish, K.S., Stroup, A., Key, C., Wiggins, C., Kahn, A.R., Schymura, M.J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S.S., Rubertone, J.J., Slack, S.J., Fulton, J.P., Rousseau, D.L., Janes, T.A., Schwartz, S.M., Bolick, S.W., Hurley, D.M., Richards, J., Whiteside, M.A., Nogueira, L.M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D.G., Cheteri, M.K., Farley, S., Hudson, A.G., Borchers, R., Stephenson, L., Espinoza, J.R., Weir, H.K., Edwards, B.K., Wang, N., Yang, L., Chen, J.S., Song, G.H., Gu, X.P., Zhang, P., Ge, H.M., Zhao, D.L., Zhang, J.H., Zhu, F.D., Tang, J.G., Shen, Y., Wang, J., Li, Q.L., Yang, X.P., Dong, J., Li, W., Cheng, L.P., Chen, J.G., Huang, Q.H., Huang, S.Q., Guo, G.P., Wei, K., Chen, W.Q., Zeng, H., Demetriou, A.V., Pavlou, P., Mang, W.K., Ngan, K.C., Kataki, A.C., Krishnatreya, M., Jayalekshmi, P.A., Sebastian, P., Sapkota, S.D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-Boker, L., Silverman, B.G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Pathy, N.B., Chimedsuren, O., Tuvshingerel, S., Al Khater, A., Al-Eid, H., Jung, K.W., Won, Y.J., Chiang, C.J., Lai, M.S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S.L., Sriplung, H., Eser, S., Yakut, C.I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A.A., Aleinikova, O.V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A.M., Faivre, J., Guizard, A.V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A.S., Daoulas, M., Clavel, J., Le Guyader-Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S.R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R.A., Kumar, V., Ólafsdóttir, E.J., Tryggvadóttir, L., Comber, H., Walsh, P.M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M.F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M.M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M.L., Tisano, F., Fanetti, A.C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M.A., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A.P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-Sroka, A., Trojanowski, M., Gózdz, S., Mezyk, R., Gradalska-Lampart, M., Radziszewska, A.U., Didkowska, J.A., Wojciechowska, U., Blaszczyk, J., Kepska, K., Bielska-Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R.A., Bastos, J., Silva, M.A., Antunes, L., Bento, M.J., Mayer-da-Silva, A., Miranda, A., Coza, D., Todescu, A.I., Valkov, M.Y., Adamcik, J., Safaei Diba, C., Primic-Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J.R., Bidaurrazaga, J., Larrañaga, N., Díaz García, J.M., Marcos, A.I., Marcos-Gragera, R., Vilardell Gil, M.L., Molina, E., Sánchez, M.J., Sureda, P.F., Montserrat, M.R., Chirlaque, M.D., Navarro, C., Ardanaz, E.E., Moreno-Iribas, C.C., Fernández-Delgado, R., Peris-Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S.M., Herrmann, C., Bulliard, J.L., Maspoli-Conconi, M., Frick, H., Kuehni, C.E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S.I., Matthes, K.L., Rashbass, J., Stiller, C.A., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R.J., Brewster, D.H., Huws, D.W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M.P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Murphy, M., Chalker, E., Newman, L., Baker, D., Soeberg, M.J., Aitken, J., Scott, C., Stokes, B.C., Venn, A., Farrugia, H., Giles, G.G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Latorre, M.R., Tanaka, L.F., Murphy, MFG, CONCORD Working Group, Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S.H., El Mistiri, M.M., Bayo, S., Malle, B., Manraj, S.S., Sewpaul-Sungkur, R., Ogunbiyi, O.J., Bradshaw, D., Somdyala, N., Stefan, D.C., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M.S., Laura, E.A., Espinola, S.B., Calabrano, G.H., Carballo Quintero, B., Fita, R., Garcilazo, D.A., Giacciani, P.L., Diumenjo, M.C., Laspada, W.D., Green, M.A., Lanza, M.F., Ibañez, S.G., Lima, C.A., de Oliveira, E.L., Daniel, C., Scandiuzzi, C., De Souza, P., Melo, C.D., Del Pino, K., Laporte, C., Curado, M.P., de Oliveira, J.C., Veneziano, C., Veneziano, D.B., Azevedo E Silva, G., Galaz, J.C., Moya, J.A., Herrmann, D.A., Vargas, S., Herrera, V.M., Uribe, C.J., Bravo, L.E., Arias-Ortiz, N.E., Jurado, D.M., Yépez, M.C., Galán, Y.H., Torres, P., Martínez-Reyes, F., Pérez-Meza, M.L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J.G., Torres-Cintrón, C.R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A.J., Woods, R.R., Noonan, G., Turner, D., Kumar, E., Zhang, B., McCrate, F.R., Ryan, S., Hannah, H., Dewar, R., MacIntyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D.E., McClure, C., Vriends, K.A., Bertrand, C., Louchini, R., Robb, K.I., Stuart-Panko, H., Demers, S., Wright, S., George, J.T., Shen, X., Brockhouse, J.T., O'Brien, D.K., Ward, K.C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A.G., Vigneau, F., MacKinnon, J.A., Wohler, B., Bayakly, A.R., Clarke, C.A., Glaser, S.L., West, D., Green, M.D., Hernandez, B.Y., Johnson, C.J., Jozwik, D., Charlton, M.E., Lynch, C.F., Huang, B., Tucker, T.C., Deapen, D., Liu, L., Hsieh, M.C., Wu, X.C., Stern, K., Gershman, S.T., Knowlton, R.C., Alverson, J., Copeland, G.E., Rogers, D.B., Lemons, D., Williamson, L.L., Hood, M., Hosain, G.M., Rees, J.R., Pawlish, K.S., Stroup, A., Key, C., Wiggins, C., Kahn, A.R., Schymura, M.J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S.S., Rubertone, J.J., Slack, S.J., Fulton, J.P., Rousseau, D.L., Janes, T.A., Schwartz, S.M., Bolick, S.W., Hurley, D.M., Richards, J., Whiteside, M.A., Nogueira, L.M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D.G., Cheteri, M.K., Farley, S., Hudson, A.G., Borchers, R., Stephenson, L., Espinoza, J.R., Weir, H.K., Edwards, B.K., Wang, N., Yang, L., Chen, J.S., Song, G.H., Gu, X.P., Zhang, P., Ge, H.M., Zhao, D.L., Zhang, J.H., Zhu, F.D., Tang, J.G., Shen, Y., Wang, J., Li, Q.L., Yang, X.P., Dong, J., Li, W., Cheng, L.P., Chen, J.G., Huang, Q.H., Huang, S.Q., Guo, G.P., Wei, K., Chen, W.Q., Zeng, H., Demetriou, A.V., Pavlou, P., Mang, W.K., Ngan, K.C., Kataki, A.C., Krishnatreya, M., Jayalekshmi, P.A., Sebastian, P., Sapkota, S.D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-Boker, L., Silverman, B.G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Pathy, N.B., Chimedsuren, O., Tuvshingerel, S., Al Khater, A., Al-Eid, H., Jung, K.W., Won, Y.J., Chiang, C.J., Lai, M.S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S.L., Sriplung, H., Eser, S., Yakut, C.I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A.A., Aleinikova, O.V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A.M., Faivre, J., Guizard, A.V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A.S., Daoulas, M., Clavel, J., Le Guyader-Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S.R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R.A., Kumar, V., Ólafsdóttir, E.J., Tryggvadóttir, L., Comber, H., Walsh, P.M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M.F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M.M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M.L., Tisano, F., Fanetti, A.C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M.A., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A.P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-Sroka, A., Trojanowski, M., Gózdz, S., Mezyk, R., Gradalska-Lampart, M., Radziszewska, A.U., Didkowska, J.A., Wojciechowska, U., Blaszczyk, J., Kepska, K., Bielska-Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R.A., Bastos, J., Silva, M.A., Antunes, L., Bento, M.J., Mayer-da-Silva, A., Miranda, A., Coza, D., Todescu, A.I., Valkov, M.Y., Adamcik, J., Safaei Diba, C., Primic-Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J.R., Bidaurrazaga, J., Larrañaga, N., Díaz García, J.M., Marcos, A.I., Marcos-Gragera, R., Vilardell Gil, M.L., Molina, E., Sánchez, M.J., Sureda, P.F., Montserrat, M.R., Chirlaque, M.D., Navarro, C., Ardanaz, E.E., Moreno-Iribas, C.C., Fernández-Delgado, R., Peris-Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S.M., Herrmann, C., Bulliard, J.L., Maspoli-Conconi, M., Frick, H., Kuehni, C.E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S.I., Matthes, K.L., Rashbass, J., Stiller, C.A., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R.J., Brewster, D.H., Huws, D.W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M.P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Murphy, M., Chalker, E., Newman, L., Baker, D., Soeberg, M.J., Aitken, J., Scott, C., Stokes, B.C., Venn, A., Farrugia, H., Giles, G.G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Latorre, M.R., Tanaka, L.F., and Murphy, MFG
- Abstract
Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia. Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for Oncology, third revision. We excluded data from registries from which the data were judged to be less reliable, or included only lymphomas, and data from countries in which data for fewer than ten children were available for analysis. We also excluded records because of a missing date of birth, diagnosis, or last known vital status. We estimated 5-year net survival (ie, the probability of surviving at least 5 years after diagnosis, after controlling for deaths from other causes [background mortality]) for children by calendar period of diagnosis (1995-99, 2000-04, and 2005-09), sex, and age at diagnosis (<1, 1-4, 5-9, and 10-14 years, inclusive) using appropriate life tables. We estimated age-standardised net survival for international comparison of survival trends for precursor-cell acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML). We analysed data from 89 828 children from 198 registries in 53 countries. During 1995-99, 5-year age-standardised net survival for all lymphoid leukaemias combined ranged from 10·6% (95% CI 3·1-18·2) in the Chinese registries to 86·8% (81·6-92·0) in Austria. International differences in 5-year survival for childhood leukaemia were still large as recently as 2005-09, when age-standardised survival for lymphoid leukaemias ranged from 52·4% (95% CI 42
- Published
- 2017
48. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study
- Author
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Moskal, A. Freisling, H. Byrnes, G. Assi, N. Fahey, M.T. Jenab, M. Ferrari, P. Tjønneland, A. Petersen, K.E.N. Dahm, C.C. Hansen, C.P. Affret, A. Boutron-Ruault, M.-C. Cadeau, C. Kühn, T. Katzke, V. Iqbal, K. Boeing, H. Trichopoulou, A. Bamia, C. Naska, A. Masala, G. De Magistris, M.S. Sieri, S. Tumino, R. Sacerdote, C. Peeters, P.H. Bueno-De-Mesquita, B.H. Engeset, D. Licaj, I. Skeie, G. Ardanaz, E. Buckland, G. Castaño, J.M.H. Quirós, J.R. Amiano, P. Molina-Portillo, E. Winkvist, A. Myte, R. Ericson, U. Sonestedt, E. Perez-Cornago, A. Wareham, N. Khaw, K.-T. Huybrechts, I. Tsilidis, K.K. Ward, H. Gunter, M.J. Slimani, N.
- Abstract
Background:Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.Results:During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk.Conclusions:Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.
- Published
- 2016
49. Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)
- Author
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Matz, Melissa, primary, Coleman, Michel P, additional, Carreira, Helena, additional, Salmerón, Diego, additional, Chirlaque, Maria Dolores, additional, Allemani, Claudia, additional, Bouzbid, S., additional, Hamdi-Chérif, M., additional, Zaidi, Z., additional, Bah, E., additional, Swaminathan, R., additional, Nortje, S.H., additional, El Mistiri, M.M., additional, Bayo, S., additional, Malle, B., additional, Manraj, S.S., additional, Sewpaul-Sungkur, R., additional, Fabowale, A., additional, Ogunbiyi, O.J., additional, Bradshaw, D., additional, Somdyala, N.I.M., additional, Stefan, D.C., additional, Abdel-Rahman, M., additional, Jaidane, L., additional, Mokni, M., additional, Kumcher, I., additional, Moreno, F., additional, González, M.S., additional, Laura, E.A., additional, Espinola, S.B., additional, Calabrano, G.H., additional, Carballo Quintero, B., additional, Fita, R., additional, Garcilazo, D.A., additional, Giacciani, P.L., additional, Diumenjo, M.C., additional, Laspada, W.D., additional, Green, M.A., additional, Lanza, M.F., additional, Ibañez, S.G., additional, Lima, C.A., additional, Lobo de Oliveira, E., additional, Daniel, C., additional, Scandiuzzi, C., additional, De Souza, P.C.F., additional, Melo, C.D., additional, Del Pino, K., additional, Laporte, C., additional, Curado, M.P., additional, de Oliveira, J.C., additional, Veneziano, C.L.A., additional, Veneziano, D.B., additional, Latorre, M.R.D.O., additional, Tanaka, L.F., additional, Azevedo e Silva, G., additional, Galaz, J.C., additional, Moya, J.A., additional, Herrmann, D.A., additional, Vargas, S., additional, Herrera, V.M., additional, Uribe, C.J., additional, Bravo, L.E., additional, Arias-Ortiz, N.E., additional, Jurado, D.M., additional, Yépez, M.C., additional, Galán, Y.H., additional, Torres, P., additional, Martínez-Reyes, F., additional, Pérez-Meza, M.L., additional, Jaramillo, L., additional, Quinto, R., additional, Cueva, P., additional, Yépez, J.G., additional, Torres-Cintrón, C.R., additional, Tortolero-Luna, G., additional, Alonso, R., additional, Barrios, E., additional, Nikiforuk, C., additional, Shack, L., additional, Coldman, A.J., additional, Woods, R.R., additional, Noonan, G., additional, Turner, D., additional, Kumar, E., additional, Zhang, B., additional, McCrate, F.R., additional, Ryan, S., additional, Hannah, H., additional, Dewar, R.A.D., additional, MacIntyre, M., additional, Lalany, A., additional, Ruta, M., additional, Marrett, L., additional, Nishri, D.E., additional, McClure, C., additional, Vriends, K.A., additional, Bertrand, C., additional, Louchini, R., additional, Robb, K.I., additional, Stuart-Panko, H., additional, Demers, S., additional, Wright, S., additional, George, J.T., additional, Shen, X., additional, Brockhouse, J.T., additional, O'Brien, D.K., additional, Ward, K.C., additional, Almon, L., additional, Bates, J., additional, Rycroft, R., additional, Mueller, L., additional, Phillips, C., additional, Brown, H., additional, Cromartie, B., additional, Schwartz, A.G., additional, Vigneau, F., additional, MacKinnon, J.A., additional, Wohler, B., additional, Bayakly, A.R., additional, Clarke, C.A., additional, Glaser, S.L., additional, West, D., additional, Green, M.D., additional, Hernandez, B.Y., additional, Johnson, C.J., additional, Jozwik, D., additional, Charlton, M.E., additional, Lynch, C.F., additional, Huang, B., additional, Tucker, T.C., additional, Deapen, D., additional, Liu, L., additional, Hsieh, M.C., additional, Wu, X.C., additional, Stern, K., additional, Gershman, S.T., additional, Knowlton, R.C., additional, Alverson, J., additional, Copeland, G.E., additional, Rogers, D.B., additional, Lemons, D., additional, Williamson, L.L., additional, Hood, M., additional, Hosain, G.M., additional, Rees, J.R., additional, Pawlish, K.S., additional, Stroup, A., additional, Key, C., additional, Wiggins, C., additional, Kahn, A.R., additional, Schymura, M.J., additional, Leung, G., additional, Rao, C., additional, Giljahn, L., additional, Warther, B., additional, Pate, A., additional, Patil, M., additional, Schubert, S.S., additional, Rubertone, J.J., additional, Slack, S.J., additional, Fulton, J.P., additional, Rousseau, D.L., additional, Janes, T.A., additional, Schwartz, S.M., additional, Bolick, S.W., additional, Hurley, D.M., additional, Richards, J., additional, Whiteside, M.A., additional, Nogueira, L.M., additional, Herget, K., additional, Sweeney, C., additional, Martin, J., additional, Wang, S., additional, Harrelson, D.G., additional, Keitheri Cheteri, M.B., additional, Farley, S., additional, Hudson, A.G., additional, Borchers, R., additional, Stephenson, L., additional, Espinoza, J.R., additional, Weir, H.K., additional, Edwards, B.K., additional, Wang, N., additional, Yang, L., additional, Chen, J.S., additional, Song, G.H., additional, Gu, X.P., additional, Zhang, P., additional, Ge, H.M., additional, Zhao, D.L., additional, Zhang, J.H., additional, Zhu, F.D., additional, Tang, J.G., additional, Shen, Y., additional, Wang, J., additional, Li, Q.L., additional, Yang, X.P., additional, Dong, J., additional, Li, W., additional, Cheng, L.P., additional, Chen, J.G., additional, Huang, Q.H., additional, Huang, S.Q., additional, Guo, G.P., additional, Wei, K., additional, Chen, W.Q., additional, Zeng, H., additional, Demetriou, A.V., additional, Pavlou, P., additional, Mang, W.K., additional, Ngan, K.C., additional, Kataki, A.C., additional, Krishnatreya, M., additional, Jayalekshmi, P.A., additional, Sebastian, P., additional, Sapkota, S.D., additional, Verma, Y., additional, Nandakumar, A., additional, Suzanna, E., additional, Keinan-Boker, L., additional, Silverman, B.G., additional, Ito, H., additional, Nakagawa, H., additional, Hattori, M., additional, Kaizaki, Y., additional, Sugiyama, H., additional, Utada, M., additional, Katayama, K., additional, Narimatsu, H., additional, Kanemura, S., additional, Koike, T., additional, Miyashiro, I., additional, Yoshii, M., additional, Oki, I., additional, Shibata, A., additional, Matsuda, T., additional, Nimri, O., additional, Ab Manan, A., additional, Bhoo-Pathy, N., additional, Tuvshingerel, S., additional, Chimedsuren, O., additional, Al Khater, A.H.M., additional, Al-Eid, H., additional, Jung, K.W., additional, Won, Y.J., additional, Chiang, C.J., additional, Lai, M.S., additional, Suwanrungruang, K., additional, Wiangnon, S., additional, Daoprasert, K., additional, Pongnikorn, D., additional, Geater, S.L., additional, Sriplung, H., additional, Eser, S., additional, Yakut, C.I., additional, Hackl, M., additional, Mühlböck, H., additional, Oberaigner, W., additional, Zborovskaya, A.A., additional, Aleinikova, O.V., additional, Henau, K., additional, Van Eycken, L., additional, Dimitrova, N., additional, Valerianova, Z., additional, Šekerija, M., additional, Zvolský, M., additional, Engholm, G., additional, Storm, H., additional, Innos, K., additional, Mägi, M., additional, Malila, N., additional, Seppä, K., additional, Jégu, J., additional, Velten, M., additional, Cornet, E., additional, Troussard, X., additional, Bouvier, A.M., additional, Faivre, J., additional, Guizard, A.V., additional, Bouvier, V., additional, Launoy, G., additional, Arveux, P., additional, Maynadié, M., additional, Mounier, M., additional, Fournier, E., additional, Woronoff, A.S., additional, Daoulas, M., additional, Clavel, J., additional, Le Guyader-Peyrou, S., additional, Monnereau, A., additional, Trétarre, B., additional, Colonna, M., additional, Cowppli-Bony, A., additional, Molinié, F., additional, Bara, S., additional, Degré, D., additional, Ganry, O., additional, Lapôtre-Ledoux, B., additional, Grosclaude, P., additional, Estève, J., additional, Bray, F., additional, Piñeros, M., additional, Sassi, F., additional, Stabenow, R., additional, Eberle, A., additional, Erb, C., additional, Nennecke, A., additional, Kieschke, J., additional, Sirri, E., additional, Kajueter, H., additional, Emrich, K., additional, Zeissig, S.R., additional, Holleczek, B., additional, Eisemann, N., additional, Katalinic, A., additional, Brenner, H., additional, Asquez, R.A., additional, Kumar, V., additional, Ólafsdóttir, E.J., additional, Tryggvadóttir, L., additional, Comber, H., additional, Walsh, P.M., additional, Sundseth, H., additional, Devigili, E., additional, Mazzoleni, G., additional, Giacomin, A., additional, Bella, F., additional, Castaing, M., additional, Sutera, A., additional, Gola, G., additional, Ferretti, S., additional, Serraino, D., additional, Zucchetto, A., additional, Lillini, R., additional, Vercelli, M., additional, Busco, S., additional, Pannozzo, F., additional, Vitarelli, S., additional, Ricci, P., additional, Pascucci, C., additional, Autelitano, M., additional, Cirilli, C., additional, Federico, M., additional, Fusco, M., additional, Vitale, M.F., additional, Usala, M., additional, Cusimano, R., additional, Mazzucco, W., additional, Michiara, M., additional, Sgargi, P., additional, Maule, M.M., additional, Sacerdote, C., additional, Tumino, R., additional, Di Felice, E., additional, Vicentini, M., additional, Falcini, F., additional, Cremone, L., additional, Budroni, M., additional, Cesaraccio, R., additional, Contrino, M.L., additional, Tisano, F., additional, Fanetti, A.C., additional, Maspero, S., additional, Candela, G., additional, Scuderi, T., additional, Gentilini, M.A., additional, Piffer, S., additional, Rosso, S., additional, Sacchetto, L., additional, Caldarella, A., additional, La Rosa, F., additional, Stracci, F., additional, Contiero, P., additional, Tagliabue, G., additional, Dei Tos, A.P., additional, Zorzi, M., additional, Zanetti, R., additional, Baili, P., additional, Berrino, F., additional, Gatta, G., additional, Sant, M., additional, Capocaccia, R., additional, De Angelis, R., additional, Liepina, E., additional, Maurina, A., additional, Smailyte, G., additional, Agius, D., additional, Calleja, N., additional, Siesling, S., additional, Visser, O., additional, Larønningen, S., additional, Møller, B., additional, Dyzmann-Sroka, A., additional, Trojanowski, M., additional, Góźdż, S., additional, Mężyk, R., additional, Grądalska-Lampart, M., additional, Radziszewska, A.U., additional, Didkowska, J.A., additional, Wojciechowska, U., additional, Błaszczyk, J., additional, Kępska, K., additional, Bielska-Lasota, M., additional, Kwiatkowska, K., additional, Forjaz, G., additional, Rego, R.A., additional, Bastos, J., additional, Silva, M.A., additional, Antunes, L., additional, Bento, M.J., additional, Mayer-da-Silva, A., additional, Miranda, A., additional, Coza, D., additional, Todescu, A.I., additional, Valkov, M.Y., additional, Adamcik, J., additional, Safaei Diba, C., additional, Primic-Žakelj, M., additional, Žagar, T., additional, Stare, J., additional, Almar, E., additional, Mateos, A., additional, Quirós, J.R., additional, Bidaurrazaga, J., additional, Larrañaga, N., additional, Díaz García, J.M., additional, Marcos, A.I., additional, Marcos-Gragera, R., additional, Vilardell Gil, M.L., additional, Molina, E., additional, Sánchez, M.J., additional, Franch Sureda, P., additional, Ramos Montserrat, M., additional, Chirlaque, M.D., additional, Navarro, C., additional, Ardanaz, E.E., additional, Moreno-Iribas, C.C., additional, Fernández-Delgado, R., additional, Peris-Bonet, R., additional, Galceran, J., additional, Khan, S., additional, Lambe, M., additional, Camey, B., additional, Bouchardy, C., additional, Usel, M., additional, Ess, S.M., additional, Herrmann, C., additional, Bulliard, J.L., additional, Maspoli-Conconi, M., additional, Frick, H., additional, Kuehni, C.E., additional, Schindler, M., additional, Bordoni, A., additional, Spitale, A., additional, Chiolero, A., additional, Konzelmann, I., additional, Dehler, S.I., additional, Matthes, K.L., additional, Rashbass, J., additional, Stiller, C.A., additional, Fitzpatrick, D., additional, Gavin, A., additional, Bannon, F., additional, Black, R.J., additional, Brewster, D.H., additional, Huws, D.W., additional, White, C., additional, Finan, P., additional, Allemani, C., additional, Bonaventure, A., additional, Carreira, H., additional, Coleman, M.P., additional, Di Carlo, V., additional, Harewood, R., additional, Liu, K., additional, Matz, M., additional, Montel, L., additional, Nikšić, M., additional, Rachet, B., additional, Sanz, N., additional, Spika, D., additional, Stephens, R., additional, Peake, M., additional, Chalker, E., additional, Newman, L., additional, Baker, D., additional, Soeberg, M.J., additional, Aitken, J., additional, Scott, C., additional, Stokes, B.C., additional, Venn, A., additional, Farrugia, H., additional, Giles, G.G., additional, Threlfall, T., additional, Currow, D., additional, You, H., additional, Hendrix, J., additional, and Lewis, C., additional
- Published
- 2017
- Full Text
- View/download PDF
50. The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)
- Author
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Matz, Melissa, primary, Coleman, Michel P, additional, Sant, Milena, additional, Chirlaque, Maria Dolores, additional, Visser, Otto, additional, Gore, Martin, additional, Allemani, Claudia, additional, Bouzbid, S., additional, Hamdi-Chérif, M., additional, Zaidi, Z., additional, Bah, E., additional, Swaminathan, R., additional, Nortje, S.H., additional, Stefan, D.C., additional, El Mistiri, M.M., additional, Bayo, S., additional, Malle, B., additional, Manraj, S.S., additional, Sewpaul-Sungkur, R., additional, Fabowale, A., additional, Ogunbiyi, O.J., additional, Bradshaw, D., additional, Somdyala, N.I.M., additional, Abdel-Rahman, M., additional, Jaidane, L., additional, Mokni, M., additional, Kumcher, I., additional, Moreno, F., additional, González, M.S., additional, Laura, E.A., additional, Espinola, S.B., additional, Calabrano, G.H., additional, Carballo Quintero, B., additional, Fita, R., additional, Garcilazo, D.A., additional, Giacciani, P.L., additional, Diumenjo, M.C., additional, Laspada, W.D., additional, Green, M.A., additional, Lanza, M.F., additional, Ibañez, S.G., additional, Lima, C.A., additional, Lobo de Oliveira, E., additional, Daniel, C., additional, Scandiuzzi, C., additional, De Souza, P.C.F., additional, Melo, C.D., additional, Del Pino, K., additional, Laporte, C., additional, Curado, M.P., additional, de Oliveira, J.C., additional, Veneziano, C.L.A., additional, Veneziano, D.B., additional, Alexandre, T.S., additional, Verdugo, A.S., additional, Azevedo e Silva, G., additional, Galaz, J.C., additional, Moya, J.A., additional, Herrmann, D.A., additional, Vargas, S., additional, Herrera, V.M., additional, Uribe, C.J., additional, Bravo, L.E., additional, Arias-Ortiz, N.E., additional, Jurado, D.M., additional, Yépez, M.C., additional, Galán, Y.H., additional, Torres, P., additional, Martínez-Reyes, F., additional, Pérez-Meza, M.L., additional, Jaramillo, L., additional, Quinto, R., additional, Cueva, P., additional, Yépez, J.G., additional, Torres-Cintrón, C.R., additional, Tortolero-Luna, G., additional, Alonso, R., additional, Barrios, E., additional, Nikiforuk, C., additional, Shack, L., additional, Coldman, A.J., additional, Woods, R.R., additional, Noonan, G., additional, Turner, D., additional, Kumar, E., additional, Zhang, B., additional, McCrate, F.R., additional, Ryan, S., additional, Hannah, H., additional, Dewar, R.A.D., additional, MacIntyre, M., additional, Lalany, A., additional, Ruta, M., additional, Marrett, L., additional, Nishri, D.E., additional, McClure, C., additional, Vriends, K.A., additional, Bertrand, C., additional, Louchini, R., additional, Robb, K.I., additional, Stuart-Panko, H., additional, Demers, S., additional, Wright, S., additional, George, J.T., additional, Shen, X., additional, Brockhouse, J.T., additional, O'Brien, D.K., additional, Ward, K.C., additional, Almon, L., additional, Bates, J., additional, Rycroft, R., additional, Mueller, L., additional, Phillips, C., additional, Brown, H., additional, Cromartie, B., additional, Schwartz, A.G., additional, Vigneau, F., additional, MacKinnon, J.A., additional, Wohler, B., additional, Bayakly, A.R., additional, Clarke, C.A., additional, Glaser, S.L., additional, West, D., additional, Green, M.D., additional, Hernandez, B.Y., additional, Johnson, C.J., additional, Jozwik, D., additional, Charlton, M.E., additional, Lynch, C.F., additional, Huang, B., additional, Tucker, T.C., additional, Deapen, D., additional, Liu, L., additional, Hsieh, M.C., additional, Wu, X.C., additional, Stern, K., additional, Gershman, S.T., additional, Knowlton, R.C., additional, Alverson, J., additional, Copeland, G.E., additional, Rogers, D.B., additional, Lemons, D., additional, Williamson, L.L., additional, Hood, M., additional, Hosain, G.M., additional, Rees, J.R., additional, Pawlish, K.S., additional, Stroup, A., additional, Key, C., additional, Wiggins, C., additional, Kahn, A.R., additional, Schymura, M.J., additional, Leung, G., additional, Rao, C., additional, Giljahn, L., additional, Warther, B., additional, Pate, A., additional, Patil, M., additional, Schubert, S.S., additional, Rubertone, J.J., additional, Slack, S.J., additional, Fulton, J.P., additional, Rousseau, D.L., additional, Janes, T.A., additional, Schwartz, S.M., additional, Bolick, S.W., additional, Hurley, D.M., additional, Richards, J., additional, Whiteside, M.A., additional, Nogueira, L.M., additional, Herget, K., additional, Sweeney, C., additional, Martin, J., additional, Wang, S., additional, Harrelson, D.G., additional, Keitheri Cheteri, M.B., additional, Farley, S., additional, Hudson, A.G., additional, Borchers, R., additional, Stephenson, L., additional, Espinoza, J.R., additional, Weir, H.K., additional, Edwards, B.K., additional, Wang, N., additional, Yang, L., additional, Chen, J.S., additional, Song, G.H., additional, Gu, X.P., additional, Zhang, P., additional, Ge, H.M., additional, Zhao, D.L., additional, Zhang, J.H., additional, Zhu, F.D., additional, Tang, J.G., additional, Shen, Y., additional, Wang, J., additional, Li, Q.L., additional, Yang, X.P., additional, Dong, J., additional, Li, W., additional, Cheng, L.P., additional, Chen, J.G., additional, Huang, Q.H., additional, Huang, S.Q., additional, Guo, G.P., additional, Wei, K., additional, Chen, W.Q., additional, Zeng, H., additional, Demetriou, A.V., additional, Pavlou, P., additional, Mang, W.K., additional, Ngan, K.C., additional, Kataki, A.C., additional, Krishnatreya, M., additional, Jayalekshmi, P.A., additional, Sebastian, P., additional, Sapkota, S.D., additional, Verma, Y., additional, Nandakumar, A., additional, Suzanna, E., additional, Keinan-Boker, L., additional, Silverman, B.G., additional, Ito, H., additional, Nakagawa, H., additional, Hattori, M., additional, Kaizaki, Y., additional, Sugiyama, H., additional, Utada, M., additional, Katayama, K., additional, Narimatsu, H., additional, Kanemura, S., additional, Koike, T., additional, Miyashiro, I., additional, Yoshii, M., additional, Oki, I., additional, Shibata, A., additional, Matsuda, T., additional, Nimri, O., additional, Ab Manan, A., additional, Bhoo Pathy, N., additional, Chimedsuren, O., additional, Tuvshingerel, S., additional, Al Khater, A.H.M., additional, Al-Eid, H., additional, Jung, K.W., additional, Won, Y.J., additional, Chiang, C.J., additional, Lai, M.S., additional, Suwanrungruang, K., additional, Wiangnon, S., additional, Daoprasert, K., additional, Pongnikorn, D., additional, Geater, S.L., additional, Sriplung, H., additional, Eser, S., additional, Yakut, C.I., additional, Hackl, M., additional, Mühlböck, H., additional, Oberaigner, W., additional, Zborovskaya, A.A., additional, Aleinikova, O.V., additional, Henau, K., additional, Van Eycken, L., additional, Dimitrova, N., additional, Valerianova, Z., additional, Šekerija, M., additional, Zvolský, M., additional, Engholm, G., additional, Storm, H., additional, Innos, K., additional, Mägi, M., additional, Malila, N., additional, Seppä, K., additional, Jégu, J., additional, Velten, M., additional, Cornet, E., additional, Troussard, X., additional, Bouvier, A.M., additional, Faivre, J., additional, Guizard, A.V., additional, Bouvier, V., additional, Launoy, G., additional, Arveux, P., additional, Maynadié, M., additional, Mounier, M., additional, Fournier, E., additional, Woronoff, A.S., additional, Daoulas, M., additional, Clavel, J., additional, Le Guyader-Peyrou, S., additional, Monnereau, A., additional, Trétarre, B., additional, Colonna, M., additional, Cowppli-Bony, A., additional, Molinié, F., additional, Bara, S., additional, Degré, D., additional, Ganry, O., additional, Lapôtre-Ledoux, B., additional, Grosclaude, P., additional, Estève, J., additional, Bray, F., additional, Piñeros, M., additional, Sassi, F., additional, Stabenow, R., additional, Eberle, A., additional, Erb, C., additional, Nennecke, A., additional, Kieschke, J., additional, Sirri, E., additional, Kajueter, H., additional, Emrich, K., additional, Zeissig, S.R., additional, Holleczek, B., additional, Eisemann, N., additional, Katalinic, A., additional, Brenner, H., additional, Asquez, R.A., additional, Kumar, V., additional, Ólafsdóttir, E.J., additional, Tryggvadóttir, L., additional, Comber, H., additional, Walsh, P.M., additional, Sundseth, H., additional, Devigili, E., additional, Mazzoleni, G., additional, Giacomin, A., additional, Bella, F., additional, Castaing, M., additional, Sutera, A., additional, Gola, G., additional, Ferretti, S., additional, Serraino, D., additional, Zucchetto, A., additional, Lillini, R., additional, Vercelli, M., additional, Busco, S., additional, Pannozzo, F., additional, Vitarelli, S., additional, Ricci, P., additional, Pascucci, C., additional, Autelitano, M., additional, Cirilli, C., additional, Federico, M., additional, Fusco, M., additional, Vitale, M.F., additional, Usala, M., additional, Cusimano, R., additional, Mazzucco, W., additional, Michiara, M., additional, Sgargi, P., additional, Maule, M.M., additional, Sacerdote, C., additional, Tumino, R., additional, Di Felice, E., additional, Vicentini, M., additional, Falcini, F., additional, Cremone, L., additional, Budroni, M., additional, Cesaraccio, R., additional, Contrino, M.L., additional, Tisano, F., additional, Fanetti, A.C., additional, Maspero, S., additional, Candela, G., additional, Scuderi, T., additional, Gentilini, M.A., additional, Piffer, S., additional, Rosso, S., additional, Sacchetto, L., additional, Caldarella, A., additional, La Rosa, F., additional, Stracci, F., additional, Contiero, P., additional, Tagliabue, G., additional, Dei Tos, A.P., additional, Zorzi, M., additional, Zanetti, R., additional, Baili, P., additional, Berrino, F., additional, Gatta, G., additional, Sant, M., additional, Capocaccia, R., additional, De Angelis, R., additional, Liepina, E., additional, Maurina, A., additional, Smailyte, G., additional, Agius, D., additional, Calleja, N., additional, Siesling, S., additional, Visser, O., additional, Larønningen, S., additional, Møller, B., additional, Dyzmann-Sroka, A., additional, Trojanowski, M., additional, Góźdż, S., additional, Mężyk, R., additional, Grądalska-Lampart, M., additional, Radziszewska, A.U., additional, Didkowska, J.A., additional, Wojciechowska, U., additional, Błaszczyk, J., additional, Kępska, K., additional, Bielska-Lasota, M., additional, Kwiatkowska, K., additional, Forjaz, G., additional, Rego, R.A., additional, Bastos, J., additional, Silva, M.A., additional, Antunes, L., additional, Bento, M.J., additional, Mayer-da-Silva, A., additional, Miranda, A., additional, Coza, D., additional, Todescu, A.I., additional, Valkov, M.Y., additional, Adamcik, J., additional, Safaei Diba, C., additional, Primic-Žakelj, M., additional, Žagar, T., additional, Stare, J., additional, Almar, E., additional, Mateos, A., additional, Quirós, J.R., additional, Bidaurrazaga, J., additional, Larrañaga, N., additional, Díaz García, J.M., additional, Marcos, A.I., additional, Marcos-Gragera, R., additional, Vilardell Gil, M.L., additional, Molina, E., additional, Sánchez, M.J., additional, Franch Sureda, P., additional, Ramos Montserrat, M., additional, Chirlaque, M.D., additional, Navarro, C., additional, Ardanaz, E.E., additional, Moreno-Iribas, C.C., additional, Fernández-Delgado, R., additional, Peris-Bonet, R., additional, Galceran, J., additional, Khan, S., additional, Lambe, M., additional, Camey, B., additional, Bouchardy, C., additional, Usel, M., additional, Ess, S.M., additional, Herrmann, C., additional, Bulliard, J.L., additional, Maspoli-Conconi, M., additional, Frick, H., additional, Kuehni, C.E., additional, Schindler, M., additional, Bordoni, A., additional, Spitale, A., additional, Chiolero, A., additional, Konzelmann, I., additional, Dehler, S.I., additional, Matthes, K.L., additional, Rashbass, J., additional, Stiller, C., additional, Fitzpatrick, D., additional, Gavin, A., additional, Bannon, F., additional, Black, R.J., additional, Brewster, D.H., additional, Huws, D.W., additional, White, C., additional, Finan, P., additional, Allemani, C., additional, Bonaventure, A., additional, Carreira, H., additional, Coleman, M.P., additional, Di Carlo, V., additional, Harewood, R., additional, Liu, K., additional, Matz, M., additional, Montel, L., additional, Nikšić, M., additional, Rachet, B., additional, Sanz, N., additional, Spika, D., additional, Stephens, R., additional, Peake, M., additional, Chalker, E., additional, Newman, L., additional, Baker, D., additional, Soeberg, M.J., additional, Aitken, J., additional, Scott, C., additional, Stokes, B.C., additional, Venn, A., additional, Farrugia, H., additional, Giles, G.G., additional, Threlfall, T., additional, Currow, D., additional, You, H., additional, Hendrix, J., additional, and Lewis, C., additional
- Published
- 2017
- Full Text
- View/download PDF
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