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Your search keyword '"Quintero, RubeN A."' showing total 389 results
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389 results on '"Quintero, RubeN A."'

10. 866 Zygosity-based Twin Pregnancy Outcomes: Insights from SNP-Based cfDNA Screening

Author

Quintero, Ruben A., primary, Hurt, Joseph, additional, Vora, Neeta L., additional, Seligman, Neil S., additional, Reilly, Gerard, additional, Wick, Myra, additional, Wolf, Samuel, additional, Hopkins, Maeve, additional, Westover, Tom, additional, Ahmadzia, Homa K., additional, Kanaan, Camille, additional, Rebarber, Andrei, additional, Kontopoulos, Eftichia V., additional, Zhang, Jingwen, additional, Egbert, Melissa, additional, Vourthis, Sophia, additional, Souter, Vivienne, additional, and Johnson, Clark T., additional

Published
2024
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11. 1117 SNP-based Prenatal Cell-free DNA Screening in Twin Pregnancies: A New Standard of Care?

Author

Quintero, Ruben A., primary, Hurt, Joseph, additional, Vora, Neeta L., additional, Seligman, Neil S., additional, Reilly, Gerard, additional, Wick, Myra, additional, Wolf, Samuel, additional, Hopkins, Maeve, additional, Westover, Tom, additional, Ahmadzia, Homa K., additional, Kanaan, Camille, additional, Rebarber, Andrei, additional, Kontopoulos, Eftichia V., additional, Zhang, Jingwen, additional, Egbert, Melissa, additional, Vourthis, Sophia, additional, Souter, Vivienne, additional, and Johnson, Clark T., additional

Published
2024
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14. The mathematical model of Schizosaccharomyces pombe : batch and repeated batch simulations

Author

Rodriguez Quintero, Ruben Dario

Subjects
579.563015118
Abstract

Mathematical models are playing an important part in the current developments in engineering, science and biotechnology. Within this field the most fashionable and representative organisms are the ones who are genetically and physiologically tractable. Since the fission yeast Schizosaccharomyces pombe plays a role model among them and its behaviour has medical, genetic and industrial links (related to cancer research, metabolic pathways and beer production), this makes it a particularly interesting organism for study. This dissertation presents the first physiological model ever developed for the yeast S. pombe. The model allows for the simulation and prediction of batch and repeated batch experiments which are an important engineering tool in terms of optimization of industrial processes improving yield in bioreactors by predicting precise values of harvest fraction (HF) and dilution cycle times (DCT). The model has been developed within the generic modelling framework of CelCyMUS (Cell Cycle Model University of Surrey). As part of the research being carried out CelCyMUS has been up-dated by introducing the new Fortran 95 features and utilities in order to exploit its powerful new features and to keep the generic model in pace with technological software advancements. The model is a one-dimensional age-based population balance for the fission yeast S. pombe. It includes the four typical phases (S, G2, M and G1) with the G2 phase divided into two phases (G2A, G2B) and two checkpoints that govern the movement of cells between G1 and S, and G2B and M phases. The transitions (movement of cells between phases) are determined by a probability function related to the consumption of glucose. The G2B-M transition is also dependent on cell size, but since individual growth of cells is related to the consumption of the carbon source (in this case glucose), cell size is dependent upon the amount of glucose consumed per cell. The model also includes a phase for cells facing starvation before going into a meiotic cycle, with some chance of coming back to the mitotic cycle, and a death phase that accounts for cells dying with no chance of recovering at all. Parameters in the S. pombe model have been gathered from experimental data in batch culture reported in literature. Data generated from this specific model have been compared with data from experiments (Fotuhi, 2002) in batch and repeated batch cultures of S. pombe following the behaviour of population balance, consumption of nutrients, and production of metabolites. The new code was tested by successftilly reproducing data from mm-321 hybridoma cell line, the first specific model of a cell line developed in CelCyMUS. As a new feature a model of mass transfer has been incorporated in the generic framework. This mass transfer module accounts for interactions of metabolites (oxygen and carbon dioxide) in the gas and liquid phase of bioreactors. The new S. pombe model was fitted to the experiments of Creanor (1992) on synchronised cultures where the consumption of oxygen was being measured. Such experiments identify two points (G2B and G1) where the rate of oxygen uptake increased in the cycle, doubling the consumption at the end of every cycle. With the model fitted to experimental results in synchronised cultures of S. pombe the model was then used to simulate desynchronised cultures. S. pombe was successfully tested when reproducing experimental data generated by Fotuhi (2002) in S.pombe for batch and repeated batch bioreactors. The S. pombe model was able to simulate cell number, oxygen and glucose consumption. Carbon dioxide and ATP production were predicted by the model however there was no experimental data to compare with. Now that the S. pombe model has been tested against experimental data it will be applied in a model-based observer strategy for the online control of bioreactors.

Published
2004

17. Hypoplastic Left Heart Syndrome With Intact or Restrictive Atrial Septum: A Report From the International Fetal Cardiac Intervention Registry

Author

Jantzen, David W., Moon-Grady, Anita J., Morris, Shaine A., Armstrong, Aimee K., Berg, Christoph, Dangel, Joanna, Fifer, Carlen G., Frommelt, Michele, Gembruch, Ulrich, Herberg, Ulrike, Jaeggi, Edgar, Kontopoulos, Eftichia V., Marshall, Audrey C., Miller, Owen, Oberhoffer, Renate, Oepkes, Dick, Pedra, Carlos A., Pedra, Simone R., Peralta, Fabio, Quintero, Ruben A., Ryan, Greg, and Gelehrter, Sarah K.

Published
2017
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22. Fetoscopic demonstration of feto-fetal hemorrhage before actual demise of a monochorionic twin, successful antenatal treatment, and narrative review of the literature.

Author

Kontopoulos, Eftichia and Quintero, Ruben A.

Subjects
*FETOFETAL transfusion, *TWINS, *MULTIPLE pregnancy, *FETAL growth retardation, *HEMORRHAGE
Abstract

Feto-fetal hemorrhage (FFH) through placental vascular anastomoses is believed to be responsible for the death or damage of a "second twin" after the demise of a "first twin (co-twin)" in monochorionic twin pregnancies. However, the timing of FFH has been difficult to determine. The resulting anemia in the surviving twin can be suspected by the finding of an elevated middle cerebral artery peak-systolic velocity (MCA-PSV), but this elevation may lag for at least 4 h after the demise of the first twin. Knowledge of the timing of FFH may have important clinical implications, as it may dictate if and when attempts to prevent death or damage to the second twin by delivery or intrauterine fetal transfusion would be warranted. We present a case that supports the notion that FFH occurs before the actual demise of the first twin. A review of the literature was also conducted. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Twin-to-twin transfusion syndrome: an antiangiogenic state?

Author

Kusanovic, Juan Pedro, Romero, Roberto, Espinoza, Jimmy, Nien, Jyh Kae, Kim, Chong Jai, Mittal, Pooja, Edwin, Sam, Erez, Offer, Gotsch, Francesca, Mazaki-Tovi, Shali, Than, Nandor G., Soto, Eleazar, Camacho, Natalia, Gomez, Ricardo, Quintero, Ruben, and Hassan, Sonia S.

Published
2008

30. 80 Outcomes of percutaneous fetoscopic open spina bifida (OSB) repair

Author

Chmait, Ramen H., primary, Chu, Jason, additional, Kontopoulos, Eftichia V., additional, Van Speybroeck, Alexander, additional, Pham, Huyen Q., additional, Ponrartana, Skorn, additional, Chon, Andrew H., additional, Llanes, Arlyn, additional, Korst, Lisa M., additional, and Quintero, Ruben A., additional

Published
2021
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32. Twin-to-twin transfusion syndrome (TTTS)

Author

Baschat, Ahmet, Chmait, Ramen H., Deprest, Jan, Gratacós, Eduard, Hecher, Kurt, Kontopoulos, Efficia, Quintero, Ruben, Skupski, Daniel W., Valsky, Dan V., and Ville, Yves

Published
2011

36. The role of laser surgery in dissecting the etiology of absent or reverse end-diastolic velocity in the umbilical artery of the donor twin in twin-twin transfusion syndrome

Author

Yao-Lung Chang, Chmait, Ramen H., Bornick, Patricia W., Allen, Mary H., and Quintero, Ruben A.

Subjects
Lasers in surgery -- Analysis, Blood transfusion -- Health aspects, Health
Abstract

The cause of absent or reverse end-diastolic velocity (AREDV) in the umbilical artery (UA) of the donor twin are described by analyzing the individual placental mass and vascular anastomoses in patients with twin-twin transfusion syndrome (TTTS) treated with laser. The results suggest that preoperative AREDV might result from a small individual placental territory (IPT), placental vascular anastomoses, or both.

Published
2006

38. Stage-based treatment of twin-twin transfusion syndrome

Author

Quintero, Ruben A., Dickinson, Jan E., Morales, Walter J., Bornick, Patricia W., Bermudez, Carlos, Cincotta, Robert, Chan, Fung Yee, and Allen, Mary H.

Subjects
Amniocentesis -- Evaluation, Fetofetal transfusion -- Care and treatment, Laser coagulation -- Evaluation, Health
Abstract

Laser photocoagulation may be more effective than amniocentesis in treating twin-twin transfusion syndrome, especially in the third trimester of pregnancy. This was the conclusion of a study of 173 women pregnant with twins whose babies were affected by this condition. Twin-twin transfusion syndrome occurs when a blood vessel malformation allows one twin to receive more blood at the expense of the other twin.

Published
2003

39. Placental types and twin-twin transfusion syndrome

Author

Bermudez, Carlos, Becerra, Carlos H., Bornick, Patricia W., Allen, Mary H., Arroyo, Jorge, and Quintero, Ruben A.

Subjects
Fetofetal transfusion -- Risk factors, Placenta -- Abnormalities, Health
Abstract

The twin-twin transfusion syndrome is most likely to happen if the placenta contains deep anastomoses rather than superficial anastomoses, according to an examination of 131 placentas. All 85 placentas with deep anastomoses resulted in twin-twin transfusion syndrome compared to only 1 of the 18 placentas with superficial anastomoses. Twin-twin transfusion syndrome occurs when one twin receives most of the nutrients and grows at the expense of the other twin.

Published
2002

43. Selective photocoagulation of communicating vessels in the treatment of monochorionic twins with selective growth retardation

Author

Quintero, Ruben A., Bornick Patricia W., Morales, Walter J., and Allen, Mary H.

Subjects
Fetus -- Growth retardation, Lasers in surgery -- Evaluation, Fetofetal transfusion -- Care and treatment, Health
Abstract

Using a laser to destroy blood vessels between twin fetuses can spare the life of one fetus when the other one has intrauterine growth retardation. If the smaller twin dies, it can adversely affect the bigger twin by taking its blood supply.

Published
2001

46. Treatment of iatrogenic previable premature rupture of membranes with intra-amniotic injection of platelets and cryoprecipitate (amniopatch): preliminary experience

Author

Quintero, Ruben A., Morales, Walter J., Allen, Mary, Bornick, Patricia W., Arroyo, Jorge, and LeParc, German

Subjects
Premature rupture of membranes -- Care and treatment, Blood platelets -- Health aspects, Health
Abstract

Injecting platelets and cryoprecipitate into the amniotic sac can seal fetal membranes that rupture prematurely. The exact location of the rupture is not important and the technique is relatively simple.

Published
1999

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