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1. Prevalencia y factores de riesgo asociados a neurocisticercosis en trabajadores del camal Conchucos, El Agustino, Perú

Author

Ana M. Solís Quispe, Tania J. Tello Chumpitaz, Danny H. Quinte Sarmiento, and Sara E. Ramírez Flores

Subjects
Neurocisticercosis, Prevalencia, Factores de riesgo, Trabajadores del camal, Medicine
Abstract

Introducción: la neurocisticercosis es una de las formas más comunes de enfermedad parasitaria del sistema nervioso central en el Perú. Objetivos: determinar la prevalencia y factores de riesgo asociados a neurocisticercosis en trabajadores de un camal. Material y Métodos: se efectuó un estudio de tipo transversal en 60 trabajadores de un camal de la capital del Perú; a los cuales se les realizó una evaluación clínica, epidemiológica y serológica (EITB), realizándose una tomografía axial computarizada a los EITB positivos. Para establecer el diagnóstico de neurocisticercosis se utilizó los criterios propuestos por Del Bruto y col. en 1996. Para determinar la prevalencia y a su vez la asociación con los factores de riesgo se empleó el paquete estadístico SPSS versión 10.0. Resultados: en la población estudiada la prevalencia de neurocisticercosis fue 1,7% y la seroprevalencia de cisticercosis del 15%. Los inadecuados hábitos higiénicos y la eliminación inadecuada de excretas fueron los factores de riesgo con mayor asociación presentando un OR de 11,6 y 2,14 respectivamente. Conclusiones: la prevalencia de neurocisticercosis para la población estudiada (1,7%) fue menor que la prevalencia nacional encontrada en autopsias de adultos (3,1%). La seroprevalencia encontrada (15%), es bastante similar a las áreas endémicas del Perú y de países como México (10,8%), Ecuador (21,4%) y Colombia (19,6%). El desconocimiento y la falta de información de estas personas sobre los mecanismos de transmisión de la neurocisticercosis explicarían la asociación con los factores de riesgo mencionados.

Published
2024

2. GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome

Author

Silvia Tiberti, Carlotta Catozzi, Ottavio Croci, Mattia Ballerini, Danilo Cagnina, Chiara Soriani, Caterina Scirgolea, Zheng Gong, Jiatai He, Angeli D. Macandog, Amir Nabinejad, Carina B. Nava Lauson, Arianna Quinte’, Giovanni Bertalot, Wanda L. Petz, Simona P. Ravenda, Valerio Licursi, Paola Paci, Marco Rasponi, Luca Rotta, Nicola Fazio, Guangwen Ren, Uberto Fumagalli-Romario, Martin H. Schaefer, Stefano Campaner, Enrico Lugli, Luigi Nezi, and Teresa Manzo

Subjects
Science
Abstract

The tumor immune microenvironment is an important prognostic determinant in colorectal cancer (CRC). Here the authors show that tumor infiltrating neutrophils expressing high levels of CD15 interact with CD8+ T effector memory skewing them to produce GZMK, associated with tumor progression in CRC patients.

Published
2022
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3. Maternal pre-pregnancy body mass index and mental health problems in early adolescents from the 2004 Pelotas birth cohort

Author

Gabriela Callo Quinte, Tiago N. Munhoz, Alicia Matijasevich, and Ina S. Santos

Subjects
Medicine, Science
Abstract

Abstract Possible mechanisms by which maternal pre-pregnancy body mass index (BMI) programs offspring mental disorders in late childhood are not fully clarified. To assess the association between maternal BMI and mental health problems at 11 years old, we used data from the 2004 Pelotas birth cohort which comprised 4231 newborns. Maternal pre-pregnancy BMI was analyzed as underweight (

Published
2022
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5. Author Correction: GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome

Author

Tiberti, Silvia, Catozzi, Carlotta, Croci, Ottavio, Ballerini, Mattia, Cagnina, Danilo, Soriani, Chiara, Scirgolea, Caterina, Gong, Zheng, He, Jiatai, Macandog, Angeli D., Nabinejad, Amir, Nava Lauson, Carina B., Quinte’, Arianna, Bertalot, Giovanni, Petz, Wanda L., Ravenda, Simona P., Licursi, Valerio, Paci, Paola, Rasponi, Marco, Rotta, Luca, Fazio, Nicola, Ren, Guangwen, Fumagalli-Romario, Uberto, Schaefer, Martin H., Campaner, Stefano, Lugli, Enrico, Nezi, Luigi, and Manzo, Teresa

Published
2022
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7. GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome

Author

Tiberti, Silvia, Catozzi, Carlotta, Croci, Ottavio, Ballerini, Mattia, Cagnina, Danilo, Soriani, Chiara, Scirgolea, Caterina, Gong, Zheng, He, Jiatai, Macandog, Angeli D., Nabinejad, Amir, Nava Lauson, Carina B., Quinte’, Arianna, Bertalot, Giovanni, Petz, Wanda L., Ravenda, Simona P., Licursi, Valerio, Paci, Paola, Rasponi, Marco, Rotta, Luca, Fazio, Nicola, Ren, Guangwen, Fumagalli-Romario, Uberto, Schaefer, Martin H., Campaner, Stefano, Lugli, Enrico, Nezi, Luigi, and Manzo, Teresa

Published
2022
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10. Análisis Técnico Económico de Protecciones en Líneas de Transmisión de 500kv para Cortocircuito y Sobrevoltaje en Referencia al Tramo San Rafael El Inga Investigación Tecnológica Ist Central Técnico

Author

Quinte Sinchi, Alex Israel, Mendoza Puruncajas, Alvaro Javier, Quinte Sinchi, Alex Israel, and Mendoza Puruncajas, Alvaro Javier

Abstract

The document addresses the importance of implementing protections on electrical transmission lines to prevent failures caused by various factors such as weather conditions, generators, insulators, transformers or human intervention. Special emphasis is placed on the need to understand the essential components of the protection system, such as relays, current and potential transformers, power switches, and various protection zones. The analysis focuses on the existing san rafael-el inga line section and seeks to provide detailed information on failures and protections with the aim of preserving the useful life of the lines and guaranteeing the safety of maintenance personnel. The construction characteristics and prices of different brands of protection relays will be compared to establish points of comparison. Data collection includes electrical parameters of the transmission line, such as resistance, conductance, inductance and capacitance, as well as the identification and analysis of different types of faults, such as short circuits and surges. Different protections are proposed, evaluating their technical and economic characteristics for an appropriate selection. The operating times of the protection relays are described, which can be instantaneous, delayed or inverse time, and their importance in the rapid detection and isolation of faults is established to avoid loss of stability in the system and reduce maintenance costs. A comparative data analysis between three protection relays is presented, highlighting the l-pro-4000 as the best option in terms of technical characteristics and price., El documento aborda la importancia de implementar protecciones en líneas de transmisión eléctrica para prevenir fallas causadas por diversos factores como condiciones climáticas, generadores, aisladores, transformadores o intervención humana. Se hace especial énfasis en la necesidad de comprender los componentes esenciales del sistema de protección, como relés, transformadores de corriente y potencial, interruptores de potencia, y diversas zonas de protección. El análisis se centra en el tramo de línea existente San Rafael-El Inga y busca proporcionar información detallada sobre fallas y protecciones con el objetivo de preservar la vida útil de las líneas y garantizar la seguridad del personal de mantenimiento. Se va a comparar las características constructivas y precios de distintas marcas de relés de protección para establecer puntos de comparación. La recolección de datos incluye parámetros eléctricos de la línea de transmisión, como resistencia, conductancia, inductancia y capacitancia, así como la identificación y análisis de diferentes tipos de fallas, como cortocircuitos y sobretensiones. Se proponen diferentes protecciones, evaluando sus características técnicas y económicas para una selección adecuada. Se describen los tiempos de operación de los relés de protección, que pueden ser instantáneos, retardados o de tiempo inverso, y se establece su importancia en la rápida detección y aislamiento de fallas para evitar pérdida de estabilidad en el sistema y reducir costos de mantenimiento. Se presenta un análisis comparativo de datos entre tres relés de protección, destacando el L-PRO-4000 como la mejor opción en términos de características técnicas y precio.

Published
2024

11. Caracterización y supervivencia de pacientes con linfoma de Hodgkin. Un reporte de 7 años de un centro único

Author

Fanny Viviana Quinte Guaiña, Rosa Nohemí Terán Terán, and Rommel Espinoza de los Monteros

Subjects
Enfermedad de Hodgkin, Linfoma Relacionado con SIDA, Mortalidad, Mortalidad Hospitalaria, Registro de Mortalidad, Análisis de supervivencia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introducción: El Linfoma de Hodgkin (LH), es una neoplasia hematológica poco frecuente, donde las células neoplásicas forman una minoría del tumor y están rodeados por un medio inflamatorio reactivo que incluye linfocitos, eosinófilos, neutrófilos, histiocitos y células plasmáticas. El objetivo del presente estudio fue describir una población con esta patología y su supervivencia en 7 años de seguimiento. Metodología: Este estudio longitudinal, se realizó en el Hospital Carlos Andrade Marín, de Quito, Ecuador, del período 2013- 2019, con una muestra no probabilística, de pacientes con LH. Se registraron variables demográficas, clínicas, de laboratorio, clasificación Ann Arbor, clasificación histológica, tratamiento y respuesta, mortalidad y tiempo de supervivencia. Se utiliza estadística descriptiva; bivariada y un análisis de supervivencia. Resultados: Se analizan 73 casos, 43 hombres (58.9 %). El grupo etáreo más prevalente fue el de 61 a 70 años con 19 casos (26 %). 1 caso (4.1 %) con VIH. El 9.6% (7 casos) recibían tratamiento con inmunosupresores. Síntomas B en 49 casos (67.1%). Adenomegalias en 15 casos (20.5 %). Masa Bulky 5 casos (6.8 %). Fallecieron 22 casos (30.1 %). Supervivencia media de 52.8 meses, el 83.6% de los pacientes recibieron Adriamicina, Bleomicina, Vincristina y Doxorrubicina como 1ra línea de tratamiento, con remisión completa en el 61.7%. El estadio IV de Ann Arbor incremento significativamente la mortalidad (HR: 3.474, IC95%: 1.202 – 6.112, P= 0.036). Pacientes con la variante de depleción linfocitaria tuvieron mayor probabilidad de fallecimiento (HR: 4.975, IC95%: 1.313 – 9.472, P= 0.041). Los valores medios de hemoglobina < 10.5 g/dL (HR: 2.395, IC95%: 1.466 – 5.941, P= 0.029), albúmina < 4 g/dL (HR: 4.020, IC95%: 1.936 – 7.257, P= 0.011) y linfocitos < 600 células/µL (HR: 4.572, IC95%: 1.853 – 11.282, P= 0.001). Conclusión: La prevalencia de LH fue ligeramente mayor en hombres que en mujeres, con una relación de 1.1: 1. La incidencia por edad tuvo dos picos, entre 31-40 años y entre 61-70 años. La diabetes e hipertensión fueron las mayores comorbilidades previas al diagnóstico. La sintomatología más frecuente fueron los síntomas B, la segunda manifestación clínica más frecuente fue adenomegalias. Los estadios II y III (Ann Arbor) fueron los más frecuentes. El promedio de Hemoglobina fue menor en los fallecidos, así como la albúmina. Para el tratamiento de primera línea se utilizó ABVD, con lo cual se alcanzó remisión completa en el 61.7% de los casos. La ausencia de síntomas B, se relacionó con una mayor supervivencia; los estadios avanzados se relacionaron con peor supervivencia; la supervivencia fue mayor en pacientes que obtuvieron remisión completa con la primera línea de tratamiento; la supervivencia no se vio afectada por el uso de radioterapia y la supervivencia general fue menor a la encontrada en países desarrollados.

Published
2022
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12. Structure-based peptide design targeting intrinsically disordered proteins: Novel histone H4 and H2A peptidic inhibitors

Author

Kanin Wichapong, Carlos Silvestre-Roig, Quinte Braster, Ariane Schumski, Oliver Soehnlein, and Gerry A.F. Nicolaes

Subjects
Disordered proteins, Peptides, Computer-aided molecular design (CAMD), Protein-protein interactions (PPIs), Histones, Neutrophil extracellular traps (NETs), Biotechnology, TP248.13-248.65
Abstract

A growing body of research has demonstrated that targeting intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) is feasible and represents a new trending strategy in drug discovery. However, the number of inhibitors targeting IDPs/IDPRs is increasing slowly due to limitations of the methods that can be used to accelerate the discovery process. We have applied structure-based methods to successfully develop the first peptidic inhibitor (HIPe - Histone Inhibitory Peptide) that targets histone H4 that are released from NETs (Neutrophil Extracellular Traps). HIPe binds stably to the disordered N-terminal tail of histone H4, thereby preventing histone H4-induced cell death. Recently, by utilisation of the same state-of-the-art approaches, we have developed a novel peptidic inhibitor (CHIP - Cyclical Histone H2A Interference Peptide) that binds to NET-resident histone H2A, which results in a blockade of monocyte adhesion and consequently reduction in atheroprogression. Here, we present comprehensive details on the computational methods utilised to design and develop HIPe and CHIP. We have exploited protein–protein complexes as starting structures for rational peptide design and then applied binding free energy methods to predict and prioritise binding strength of the designed peptides with histone H4 and H2A. By doing this way, we have modelled only around 20 peptides and from these were able to select 4–5 peptides, from a total of more than a trillion candidate peptides, for functional characterisation in different experiments. The developed computational protocols are generic and can be widely used to design and develop novel inhibitors for other disordered proteins.

Published
2021
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13. FUNDAMENTOS E PRÁTICAS PEDIÁTRICAS E NEONATAIS

Author

Rafael, Ana Luísa Bonfim, primary, Pontes, Nayanne Hardy Lima, additional, Chaves, Melissa Magalhães Rodrigues, additional, Ferreira, Nathalya Menezes de Menezes, additional, Martins, Juliana Bezerra, additional, Landim, Sâmia Marques Lourenço, additional, Vasconcelos, Izabella Tamira Galdino Farias, additional, SILVA, MARIANA PEREIRA BARBOSA, additional, Loures, Leandro Luiz da Silva, additional, Moura, Layanne Cavalcante de, additional, Santos, Jéssika Roberta Firme de Moura, additional, Fonseca, Natana Maranhão Noleto da, additional, Fonseca, Vanessa Maranhão Noleto da, additional, Santos, Beatriz Sousa, additional, Moura, Viviane Silva de, additional, Gomes, Yulle Morais, additional, Apolinário, Joelma Maria dos Santos da Silva, additional, Ferreira, Barbara Rodrigues, additional, Dias, Nathália M, additional, Sousa, Samilly Lorâna Farias de, additional, Rocha, Samara Atanielly, additional, Bastos, Melissa Cavalcante, additional, Sousa, Maria do Livramento Siqueira, additional, Silva, Manoel Leonardo Tavares da, additional, Nascimento, Cidianna Emanuelly Melo do, additional, Souza, Vitória Caroline dos Santos de, additional, Souta, Elaine Soares, additional, Lopes, Layane Sampaio, additional, Lobato, Merivalda Vasconcelos, additional, Santos, Mirlena Letícia Souza dos, additional, Sanches, Raiane Pereira, additional, Morais, Raquel Pereira, additional, Vieira, Rosiene Rodrigues, additional, Almeida, Silmara Nayra Silva, additional, Silva, Thais de Melo da, additional, Souza, Vitória Caroline dos Santos, additional, Dias, Nathália Menezes, additional, Ferreira, Nathálya M de M, additional, Rafael, Ana Luisa B, additional, Martins, Juliana B, additional, Chaves, Melissa M R, additional, Vasconcelos, Izabella Tamira G F, additional, Feitosa, Maria Clara Duarte, additional, Nunes, Camila da Silva Lopes, additional, Viana, Carine Cristina Oliveira, additional, Santos, Zaira Antônia Sousa Dos, additional, Frota, Maria Madalena Cardoso Da, additional, Silva, Letícia Alves Rodrigues, additional, Torres, Samir Da Rocha Fernandes, additional, Rocha, Maria Izabel Felix, additional, Barros, Ingrid Cristina Rêgo, additional, Barros, Cassandra M A R, additional, Almeida, Joelson dos Santos, additional, Desto, Nádia Beatriz, additional, Santos, Teresa Cristina Maia dos, additional, Borges, Bruna da Cruz Beyruth, additional, Silva, Ana Flávia Lima, additional, Cardoso, Gabriela Alexandra Amaral, additional, Leal, Gabriely do Nascimento, additional, Raposo, Júlia Cordeiro Brandão, additional, Borges, Lara Freitas, additional, Ferreira, Rayne Curto do Nascimento, additional, Machado, Renata Leão, additional, Barros, Thiago Botelho de, additional, Couto, Amanda Vieira, additional, Saldanha, Janaína Cláudia da Silva, additional, Aguiar, Alessandra N de, additional, Lopes, Ana Luísa Junho, additional, Tsutsumi, Ariane Abreu, additional, Mendes, Emanuelle Xavier Martins, additional, Ferreira, Karina Fernandes Ruiz, additional, Castro, Pedro Keese de, additional, Marco, Valentina Maria Fernandes de, additional, Menezes, João Daniel de Souza, additional, Rosário, Jéssica Reis Do, additional, Alves, Nágila Silva, additional, Soares, Rosana Maria Nogueira Gonçalves, additional, Gonçalves, Fernanda de Sousa, additional, Oliveira, Luinê Ferreira de, additional, Silva, Aline Alves da, additional, Homem, Dayla Soeiro, additional, Silva, Keulle Mayara Barros do Nascimento, additional, Oliveira, Naynne Fernanda Galvão de, additional, Silva, Emylla De Sousa, additional, Oliveira, Brian Araujo, additional, Cunha, Victória da Silva da, additional, Leandro, Andressa Muniz, additional, Alves, Adriely Martins da Conceição, additional, Almeida, Rayane Oliveira, additional, Carneiro, Ana Luiza, additional, Faria, Kathleen Emerick Paiva, additional, Lima, Aleksander Luís, additional, Silva, Bruna Gonçalves da, additional, Soares, Carolina Rocha, additional, Costa, Cynthya Magalhães, additional, Miareli, Felipe, additional, Moscardini, Ighor Monteiro, additional, Carvalho, Isadora Saddi de, additional, Pastro, João Félix de Mattos, additional, Bueno, João Victor de Moraes, additional, Vieira, Júlia Marques, additional, Costa, Letícia, additional, Meira, Melissa Andrade, additional, Guimarães, Rodrigo Quinte, additional, Matos, Romulo Vasconcellos Ribeiro, additional, Alves, Allana Victória Pereira, additional, Cavalcante, Alícia Tenório, additional, Fechine, Amanda Macêdo, additional, Almeida, Ana Beatriz Dantas de, additional, Cruz, Elizabeth Fechine, additional, Rocha, Fernanda Sampaio Feitosa, additional, Silva, Islânia Pacheco da, additional, Macedo, Julia Tenório Lossio de, additional, Lima, Laura de Souza, additional, Pereira, Maria Eduarda Coutinho da Franca, additional, Matias, Maria Inês de Araújo Sousa, additional, Roque, Maria Luiza Teixeira de Carvalho, additional, Moraes, Sabryna Meira Carvalho de, additional, Pereira, Sibely Coelho Urbano, additional, Santos, Taynara Souza, additional, Said, Beatriz Rigoli, additional, Abreu, Barbara Seffair de Castro de, additional, Moraes, Bruna Maria Pedrosa, additional, Leão, Nayara Paloma Carvalho de Oliveira, additional, Paiva, Maria Noel Rigoli, additional, Pereira, Andrea Ferreira, additional, Santos, Francy Hadarssa Albuquerque dos, additional, Resende, Giovanna Medeiros, additional, Lima, Gyovanna Braz Porto de Queiroz Ribeiro, additional, Campos, Joanny Elizabeth Maria Pimentel, additional, Lima, Leticia Britto Gama de, additional, Jesus, Maisa Mendonça de, additional, Teixeira, Maria Eduarda Montenegro Damaso, additional, Maciel, Maria Izadora Sena, additional, Lima, Letícia Britto Gama de, additional, Jesus, Maísa Mendonça de, additional, Vilefort, Laís Assunção, additional, Lopes, Amanda Brandão, additional, Vidal, Laura de Oliveira Veloso, additional, Pereira, Sofia Lúcia El Hauche, additional, Campos, Isadora Assunção Vaz Porto, additional, Lobato, Júlia Lacerda, additional, Silva, Isadora Faria, additional, Campos, Laura Assunção Vaz Porto, additional, Pinto, Letícia Maria Barbosa, additional, Silva, Juliana Cardoso da, additional, Oliveira, Bianca Veloso Vidal de, additional, Oliveira, Juliana Karine de, additional, Brito, Warlon Jorge, additional, Silva, Rachel Macêdo Souza Pedro da, additional, Jardim, Paula Fulgêncio Tanure, additional, França, Gabriel Eugênio Esteves Rocha, additional, Nunes, Beatriz Carnevalli, additional, Lobato, Gustavo de Freitas, additional, Oliveira, Andressa Pâmela de, additional, Costa, Rayssa Mara Ferreira, additional, Gonçalves, Ana Luiza Lima, additional, Pereira, André Luís Campos Louredo, additional, Sabino, Izadora Marina de Oliveira, additional, Ribeiro, Ayla Silva Sygilião, additional, Gomes, João Adriel Rodrigues, additional, Cardoso, Bruna do Nascimento, additional, Magalhães, Felipe Pueyo, additional, Figueiredo, Anna Luísa Rodrigues Soares Silva, additional, Oliveira, Julia de Paula, additional, silva, Haroldo Souza e, additional, Pinto, Andressa Leodorico, additional, Frade, Laura Vitória de Oliveira, additional, Vieira, Júlia Diniz Marra, additional, Viana, Maria Elisa Latini, additional, Cunha, Jorge Romel, additional, Guedes, Mayco Oliveira, additional, Pinheiro, Fernanda Dias, additional, Silveira, Rachel Pimentel Romano, additional, Trindade, Ana Vivian de Miranda, additional, Martins, Marinna Avatar, additional, andrade, Lorenzo brezinski bellinazzi de, additional, Faria, Moisés Lopes Cançado de, additional, Guimarães, Camila Campos Avelar, additional, Nunes, Patricia Pimenta, additional, Carmo, Leticia Saad do, additional, Magalhães, Pedro Antônio Ribeiro Dayrell, additional, Leal, Ana Luiza Alvim, additional, Guedes, Denis da Silva, additional, Souza, Clara Martins Resende de, additional, Possa, Dalila Percilia Siqueira, additional, Cerbarro, Gabrielle Fernanda, additional, Costa, João Pedro Souza Ferreira, additional, Oliveira, Bárbara Martins Mello de, additional, Oliveira, Dara Campos de, additional, Costa, Henrique Brandião, additional, Magalhães, Ícaro Silva, additional, Silva, Ingrid Duarte da, additional, Costa, Ivy Letícia Brandião, additional, Martins, Mariah Prado, additional, Lisboa, Victória Sardinha de, additional, Cacau, Leandro Gervasio Antunes, additional, Oliveira, Victória Martins Mello de, additional, Rocha, Anderson de Almeida, additional, Junqueira, Camila Fonseca Silva, additional, Andrade, Kayan Felipe de Oliveira, additional, Gomes, Matheus Esquerdo, additional, Parma, Isabela Teixeira, additional, Souza, Gustavo Meirelles, additional, Freguglia, Philippe Guedes, additional, Melo, Júlia Carvalho de, additional, Antunes, Victor Rocha Moreira, additional, Soares, Pedro Veiga de Paula, additional, Pompei, Vinícius Abritta, additional, Junqueira, Laís Silveira, additional, Delphino, Anna Laura Lima, additional, Oliveira, Luciano José Fontes de, additional, Oliveira, Lucas Avinner Afonso de, additional, Ferreira, Nathalia de Araújo, additional, Pires, Victoria Cristina Lodron, additional, Pereira, Luis Fernando Mendes, additional, Pires, Paulo Henrique Lobato, additional, mesquita, Gabriel Albuquerque, additional, Vieira, João Pedro Santana, additional, Almeida, Beatriz Martins Guerra Pantuza, additional, Avelar, João Victor de Miranda, additional, Brandão, Renata Alvares, additional, Morais, Mariana Melo de, additional, Barbosa, Mário Henrique Araújo, additional, Oliveira, Fernanda Silva de, additional, Siqueira, Ana Luiza Faria e, additional, Fonseca, Camilla Gonçalves Corradi, additional, Barcelos, Rafaella Viana Ferreira, additional, Pouza, Matheus Henrique Campos, additional, Coutinho, Thais Dias, additional, Fiorilo, Luciana Calderano, additional, Sidrim, Gustavo Henrique Silva, additional, Santos, Camila Aparecida Campos, additional, Neves, Flavia Bedeti, additional, Pimenta, Aline Vilela, additional, Jabour, Matheus Silva Cordeiro, additional, Barreto, João Murta, additional, Barreto, Pedro Murta, additional, Hostt, Luísa Pettz Oliveira, additional, Ferreira, Tulio Coura Moreira dos Santos, additional, Vieira, Pedro Henrique Gomes, additional, Graça, Gabriela Arantes da Cunha, additional, Alves, Vinícius Tadeu Silveira, additional, Goulart, Jéssica, additional, Parisi, Mariana Migliorini, additional, Cattaneo, Roberta, additional, Martins, Rebeca da Gama Cerqueira Ferraz, additional, Rachid, Marina de Moura, additional, Santana, Mariana Briglia de, additional, Rachid, Clara de Moura, additional, Santos, Emília Oliveira, additional, Mendonça, Larissa Lima Pessoa de, additional, Nascimento, Isabella Lima, additional, Sapori, Angélica Navarro, additional, Moraes, Liliane Regina de Souza, additional, Costa, Danielle Lima da, additional, Pissolatto, Gabrielle Grecov, additional, Carvalho, Marianne Rocha Duarte de, additional, Rocha, Silvana Santiago da, additional, Sales, Isabela Maria Magalhães, additional, Figueiredo, Emmanoel Martins, additional, Araújo, Vitória Jannyne Guimarães de Sousa, additional, Sales, Pedro Henrique Barbosa, additional, Ferrer, Iago Araújo, additional, Marinho, Denis Pontes, additional, Lima, Marcos Roberto de Oliveira, additional, Bezerra, Maria Victoria Hiluy Habibe, additional, Mota, Antônio Alberto Bastos, additional, Vidal, Brayon Freire Blanquett, additional, Cavalcante, Ana Carolina Pinheiro Frota, additional, Paula, Rebeka Ventura Pessôa de, additional, Aguiar, Aryane Cruz, additional, Sampaio, Rafaela Montenegro Aires, additional, Holanda, Abner Pedrosa, additional, Rodrigues, Marina Machado, additional, Lisboa, Débora D'Agostini Jorge, additional, Amarante, Michael Vieira do, additional, Rezende, Ana Cristina Arruda, additional, Rabelo, Ana Luiza Andrade, additional, Oliveira, Bianca Nascimento, additional, Batista, Fernanda Ribeiro Gonçalves Bolina, additional, Passos, Giovana Lemos, additional, Souza, Ingra Kozlovwsky, additional, Barros, Isabella de Caux Saez Bragança, additional, Lima, Lavínia Nobre Moraes, additional, Costa, Mariana Isabel Alvim, additional, Nadais, Giovana Lopes, additional, LUSTOSA, CARLA RODRIGUES, additional, Freitas, Gabriela Moura, additional, Oliveira, Juliana Barros Vianna de, additional, CARDOSO, LUÍSA RODRIGUES, additional, Leal, Miriam Martins, additional, Pereira, Ana Luíza Oliveira, additional, Porto, Anna Clara Colen, additional, Carvalho, Anna Luiza Homan Araújo, additional, Melo, Bruna Portela Costa Ferreira de, additional, Teatini, Clarissa Moreira, additional, Souza, Helanny Dutra de, additional, Melo, Arthur Lira de, additional, Andrade, Camilla Katarine Delgado, additional, Sobral, Ellen Beatriz, additional, Santos, Isabelle Thaís da Silva, additional, Macedo, João Victor Tenório Lossio de, additional, Menezes, Marcelo Diniz de, additional, Gomes, Maria Clara Cirilo, additional, Matias, Maria Eduarda Borges, additional, Ferreira, Maria Eduarda Rodrigues, additional, Ramos, Mônica Moura, additional, Oliveira, Osman Lucena Félix de, additional, Moreira, Cibely Souza Ribeiro, additional, Madeira, Fernanda Orlando Pompeu, additional, Gaia, Gabriel Gontijo Guimarães, additional, Wulf, Isabela Gondim, additional, Feijóo, Isabella Cheremetta, additional, Anacleto, José Hyde Augusto Zschaber, additional, Cabral, Julia Alice Borges, additional, Caetano, Juliana Dias Moreira, additional, Araújo, Juliana Maria Mendes de, additional, Pereira, Lêda Mendes, additional, Sousa, Virgínia Araújo de, additional, Lage, Yasmin Souza, additional, Uggioni, Natália Custódio, additional, Zanatta, Luiza Mazzucco, additional, Santos, Gabriela Nuernberg dos, additional, Tonial, Julia Sgarbossa, additional, Reichert, Júlia Turra, additional, Bazotti, Lara Xavier, additional, Duarte, Gabriela Ugioni, additional, Teixeira, Letícia Maffioletti, additional, Dalponte, Letícia de Stefani, additional, Teixeira, Maria Julia Lindermann Peressoni, additional, Colombo, Cecília Colonetti, additional, Santos, Ana Carolina Bezerra Chagas, additional, Teixeira, Beatriz Sotéro Oliveira, additional, Sales, Renata Vitoria de Fraça, additional, Guimarães, Laura Amédée Péret, additional, Vieira, Lara Silveira, additional, Pena, Lavínia Vasconcellos Patrus, additional, Nepomuceno, Lara Reggiani, additional, Moreira, Luiz Felipe Guimarães Gualberto, additional, Rangel, Laura Kapp, additional, Ramalho, Lívia Corrêa, additional, Queiroz, Isabella Timbó, additional, Andrade, Maria Denise Fernandes Carvalho de, additional, Carvalho, Ellaine Dóris Fernandes, additional, Paiva, Viviane Nogueira de, additional, Rocha, Nadiny Francis Silveira, additional, Souza, Maria Carolina Sticanele de, additional, Vieira, Nelmara Alvarenga, additional, Lages, Laryssa Guimarães, additional, Mata, Luísa Oliveira Santos Da, additional, Lembrance, Lara Macedo, additional, Roque, Natália Lages, additional, Faria, Ana Luísa Braga Abalen, additional, Maia, Maria Eduarda De Lima, additional, Fernandes, Thiago Barbosa, additional, Mendonça, Stephany Brini de, additional, Duarte, Melissa Nadal, additional, PESSANHA, DAYANE JARDIM, additional, Marques, Larissa de Oliverira Cassini, additional, Pereira, Laura Costa, additional, Camargo, Anna Cláudia Domínguez Alves Bohn de, additional, Carvalho, Luma Alves Fonseca, additional, Fujimoto, Ruth Helena Pimenta, additional, Cordeiro, Aline Araújo, additional, Carvalho, Victoria Cristina de Jesus, additional, Lima, Vitória Emily Amorim, additional, Cabral, Luana Guimarães Lima, additional, Cavalcanti, Amanda Vanessa Bandeira de Araújo, additional, Fireman, Gabriela Holanda Carvalho, additional, Lima, Maria Carolina Oliveira, additional, Farias, Vandriely Marie de Albuquerque, additional, Oliveira, Letícia Brandão Barbosa de, additional, Ferreira, Maria Eduarda Rech, additional, Sirqueira, Sarah Valões Tenorio, additional, Cardoso, Paula Thaís Sousa de Oliveira, additional, Cavalcanti, Isabela de Farias, additional, Monteiro, Marcos Brunno Aguiar, additional, Perezini, Renato de Paula, additional, Costa, Víctor de Oliveira, additional, Rosa, Marlon José dos Santos, additional, Lima, Hugo Tomé de Souza, additional, Freitas, Pedro Carvalho, additional, Adriano, Ana Paula dos Santos, additional, Pereira, Maria Eduarda Ribeiro Coutinho da Franca, additional, Nunes, Beatriz Carnevalli Motta, additional, Costa, João Lucas Santiago Angelos, additional, Rocha, Raphael Alves, additional, Goulart, Jessica dos Santos, additional, and Siqueira, Maria Luiza Andrade, additional

Published
2021
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14. Temas Selectos en Medicina Interna Vol. 3

Author

Ríos Quinte, Raúl Jonathan, primary, Salazar Santana, Sandy Carola, additional, Torres Castillo, Kelvin Alexander, additional, Navarrete Bolaños, Karla Abigail, additional, Calle Mourin, Ricardo Enrique, additional, Montenegro Salas, Daniela Stephanie, additional, López García, Marlon Andrés, additional, Gavilanes Acosta, Daisy Maribel, additional, Barahona Ochoa, Katty Magdalena, additional, Ponce Alencastro, Jhon Alexander, additional, González Romero, Daniel Andrés, additional, Encalada Granda, Santiago Leonel, additional, Vela Yar, Jorge Steeven, additional, Coello Merino, Jenny Antonella, additional, Curipoma Aguinsaca, Verónica Alejandra, additional, Bravo Otoya, Andrea Estefania, additional, Abarca Aldean, Silvana Patricia, additional, Hidalgo Robalino, Liliana del Carmen, additional, and Ramírez Ruiz, Carlos Jaír, additional

Published
2021
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15. La imagen de la juventud en la publicidad televisiva del Perú

Author

Silvia Liseti Quinte Rodríguez, Rubén Darío Alania Contreras, and Víctor Ricardo Flores Rivas

Subjects
juventud, imagen, estereotipo, publicidad, televisión, Social sciences (General), H1-99
Abstract

La investigación tuvo como objetivo caracterizar la imagen de la juventud mostrada en la publicidad televisiva del Perú, definiendo qué papel se asigna a los jóvenes en las piezas publicitarias de la televisión peruana. El estudio, de tipo básico y diseño descriptivo simple, tomó una muestra de 100 spots publicitarios, emitidos durante los meses de julio, agosto y setiembre de 2019. Se aplicó como instrumento de recolección de datos, la ficha de análisis de contenido de imagen de la juventud, diseñada para la investigación. Se halló que, predominantemente, se muestra a jóvenes de fenotipo caucásico, atlético y que destacan por su atractivo físico, con roles de belleza, cuidado del cuerpo y la propia imagen, teniendo el placer como objetivo principal. Se concluye que la imagen de la juventud en la publicidad televisiva nacional es discriminativa en el fenotipo que representa; superficial y hedonista, en los roles asignados, y homogenizante, en preferencias juveniles. DOI: https://doi.org/10.31876/sl.v4i1.53

Published
2020
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19. Author Correction: GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome

Author

Silvia Tiberti, Carlotta Catozzi, Ottavio Croci, Mattia Ballerini, Danilo Cagnina, Chiara Soriani, Caterina Scirgolea, Zheng Gong, Jiatai He, Angeli D. Macandog, Amir Nabinejad, Carina B. Nava Lauson, Arianna Quinte’, Giovanni Bertalot, Wanda L. Petz, Simona P. Ravenda, Valerio Licursi, Paola Paci, Marco Rasponi, Luca Rotta, Nicola Fazio, Guangwen Ren, Uberto Fumagalli-Romario, Martin H. Schaefer, Stefano Campaner, Enrico Lugli, Luigi Nezi, and Teresa Manzo

Subjects
Science
Published
2022
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20. Blue-Collar Workers: Study on Physically Demanding Jobs.

Author

Venancio, Francia A., Quinte, Jessille Ann D., and Sengco, Bea Teresa S.

Subjects
JOB satisfaction, RESEARCH personnel, RETIREMENT income, THEMATIC analysis, SEMI-structured interviews, BABY boom generation
Abstract

The researcher used a Qualitative approach, specifically phenomenological design, and used a semi-structured interview to gather in-depth data about the worker's perspective and experiences. Also used thematic analysis to organize and identify the theme that will come out. The study establishes the two main reasons why blue-collar workers stay in their jobs and these are to sustain the family needs and attain job satisfaction. The workers also added that they are motivated and determined to work hard to be the provider for the family and are satisfied with their jobs. Achieving job satisfaction by the workers has a reason behind it, it is having a good relationship with workmates and equal salary. In addition, the research showed that some blue-collar workers want to manage their businesses to generate income for their retirement, investing whatever they have saved from their work. For future researchers, reconducting this research on a larger population and wider area will supply a broader perspective of the workers, this will help the succeeding researchers to provide new information at a more modern and faster pace. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Overweight trajectory and cardio metabolic risk factors in young adults

Author

Gabriela Callo Quinte, Fernando Barros, Denise Petrucci Gigante, Isabel Oliveira de Oliveira, Janaína Vieira dos Santos Motta, and Bernardo Lessa Horta

Subjects
Obesity, Trajectory, Cardiometabolic risk factors, Young adults, Pediatrics, RJ1-570
Abstract

Abstract Background Obesity is one of the conditions that increases the risk of cardiovascular disease. Studies about obesity trajectory and cardio metabolic outcomes at adulthood are still scarce. Therefore, we aimed to assess the association between patterns of overweight over the life-course and cardio metabolic risk factors in young adults. Methods In 1982, the maternity hospitals in Pelotas were visited daily and those newborns whose family lived in the urban area of the city were identified (n = 5914), and have prospectively followed for several occasions. Weight and height were measured at every visit. BMI-for-age z-score was calculated using the WHO Child Growth Standards. Overweight and obesity were defined as a BMI greater than or equal to 25 kg/m2 and 30 kg/m2 respectively. This was the definition adopted for evaluations overweight and obesity at 30 years. The participants were divided into eight groups according to the presence of overweight or obesity in childhood, adolescence and adulthood. Blood pressure, random blood glucose, HDL cholesterol, LDL cholesterol triglycerides and fat mass were measured. Results From 2219 participants with anthropometric data in childhood, adolescence and adulthood, 25% never had been overweight, whereas 11.6% were overweight in the three periods. Random blood glucose, SBP and DBP were higher among those subjects who were always overweight/ obese or only overweight/obese during adolescence and adulthood. The participants who were never overweight/obese or only in childhood or adolescence had a lower cardiovascular risk profile (higher HDL cholesterol, lower blood pressure, lower random glucose, lower LDL cholesterol) at 30 years. Fat mass captured from 25 to 100% of the association of overweight and obesity trajectory with cardiometabolic risk factors. Conclusions The tracking of overweight/obesity is associated with an adverse cardio metabolic profile and this association is largely mediated by fat mass in adulthood.

Published
2019
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23. Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability

Author

Asare, Yaw, Campbell-James, Thomas A., Bokov, Yury, Yu, Lydia Luya, Prestel, Matthias, El Bounkari, Omar, Roth, Stefan, Megens, Remco T.A., Straub, Tobias, Thomas, Kyra, Yan, Guangyao, Schneider, Melanie, Ziesch, Natalie, Tiedt, Steffen, Silvestre-Roig, Carlos, Braster, Quinte, Huang, Yishu, Schneider, Manuela, Malik, Rainer, Haffner, Christof, Liesz, Arthur, Soehnlein, Oliver, Bernhagen, Jürgen, and Dichgans, Martin

Published
2020
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24. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

Author

Silvestre-Roig, Carlos, Braster, Quinte, Wichapong, Kanin, Lee, Ernest Y., Teulon, Jean Marie, Berrebeh, Nihel, Winter, Janine, Adrover, José M., Santos, Giancarlo Santiago, Froese, Alexander, Lemnitzer, Patricia, Ortega-Gómez, Almudena, Chevre, Raphael, Marschner, Julian, Schumski, Ariane, Winter, Carla, Perez-Olivares, Laura, Pan, Chang, Paulin, Nicole, Schoufour, Tom, Hartwig, Helene, González-Ramos, Silvia, Kamp, Frits, Megens, Remco T. A., Mowen, Kerri A., Gunzer, Matthias, Maegdefessel, Lars, Hackeng, Tilman, Lutgens, Esther, Daemen, Mat, von Blume, Julia, Anders, Hans-Joachim, Nikolaev, Viacheslav O., Pellequer, Jean-Luc, Weber, Christian, Hidalgo, Andrés, Nicolaes, Gerry A. F., Wong, Gerard C. L., and Soehnlein, Oliver

Published
2019
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25. Percepción de las medidas de salud pública en Perú para frenar el avance de la COVID-19

Author

Christian R. Mejia, Dayana Ticona, J. Franco Rodriguez-Alarcon, Alejandra M. Campos-Urbina, Humberto Garayar-Peceros, Jhordan B. Catay-Medina, Thalia Porta-Quinto, Lizet Garay-Rios, Christian Ignacio-Quinte, and Sonya Guevara-Sosa

Subjects
coronavirus, infecciones por coronavirus, gobierno, salud pública., Medicine (General), R5-920
Abstract

Introducción: Es importante medir en la población la percepción del impacto que han tenido las medidas adoptadas por los gobiernos ante la rápida expansión del coronavirus. Objetivo: Determinar la percepción de las medidas implementadas por el gobierno de Perú en materia de salud pública para frenar el avance de la COVID-19. Métodos: Estudio transversal, analítico y multicéntrico, para el cual se hizo una encuesta virtual en la que participaron más de 4000 personas de todo el país. Resultados: La gran mayoría estaban a favor que esta es una epidemia/pandemia grave (47 % de acuerdo y 42 % muy de acuerdo), sin embargo, solo el 22 %, 21 %, 17 % y 46 % que el país, el sector salud, los hospitales y los médicos, respectivamente, están preparados para enfrentarla. Las medidas más apoyadas en cuanto a migración fueron la aprobación del cierre de fronteras (68 % muy de acuerdo) y no dejar entrar a quienes estuvieron en China u otros países con elevadas cifras de casos de coronavirus (60 % muy de acuerdo). Asimismo, estuvieron de acuerdo que no deben celebrarse eventos masivos por un tiempo (69 % muy de acuerdo), seguidos por quienes proponían declarar la salud pública en emergencia (61 % muy de acuerdo) y el cierren de colegios y universidades por un tiempo (50 % muy de acuerdo). Se encontraron muchas asociaciones estadísticas de estas percepciones, según sexo, edad o grado académico (p < 0,05). Conclusiones: La población estuvo de acuerdo con la mayoría de las medidas, algunas fueron más apoyadas y estuvieron asociadas a las características socioeducativas.

Published
2020

26. Pressão arterial elevada em escolares de 7 a 10 anos da rede de ensino de um município rural do Espírito Santo

Author

Camila Brandão-Souza, Cláudia de Souza Dourado, Gabriela Callo Quinte, Gláucia Figueiredo Justo, and Maria Del Carmen Bisi Molina

Subjects
criança, pressão alta, hipertensão, Public aspects of medicine, RA1-1270
Abstract

Resumo Objetivo Estimar a prevalência de níveis pressóricos elevados em escolares de 7 a 10 anos de um município rural do Espírito Santo entre os anos de 2009 e 2010; avaliar a associação da pressão arterial elevada com idade, sexo e estado nutricional. Método Estudo transversal, com amostra de 899 escolares de 7 a 10 anos residentes em um município rural do Espírito Santo. Os dados foram coletados por meio de questionários e as crianças foram submetidas a medidas antropométricas e de pressão arterial. Realizou-se dupla digitação, utilizou-se o programa SPSS 17.0. para análises estatísticas e o teste de hipótese qui-quadrado para determinar as associações. Resultados Dos 899 participantes, houve prevalência de 16,2% de pressão arterial elevada, sem diferença significativa por sexo (p = 0,343) e idade (p = 0,47). Crianças com excesso de peso apresentaram maior prevalência de pressão alta, assim como maior média de pressão arterial sistólica e diastólica. Encontraram-se diferenças significativas entre as médias de pressão arterial sistólica com relação ao sexo (p < 0,001) e idade (p = 0,016). Conclusão A prevalência média da pressão arterial elevada foi maior nos meninos, que apresentaram também maior prevalência na pressão arterial limítrofe. Apresentar excesso de peso contribuiu de forma significante para a elevação da pressão arterial.

Published
2018
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27. Determinants of high blood pressure in children: a case-control study in a rural area of the Espírito Santo State / Determinantes da pressão arterial elevada em crianças: um estudo caso-controle em área rural do Espírito Santo

Author

Camila Brandão-Souza, Claudia Souza Dourado, Gabriela Callo Quinte, Gláucia Figueiredo Justo, and Maria Del Carmen Bisi Molina

Subjects
Criança, Pressão alta, Hipertensão, Medicine, Nursing, RT1-120
Abstract

Objetivo: Identificar e analisar os fatores preditores da ocorrência da pressão arterial elevada em crianças de 7 a 10 anos de um município rural no Espírito Santo. Métodos: Foram constituídos dois grupos de estudo: os casos (PAS ou PAD ≥ P95) e os controles (PA

Published
2018
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29. Interleukin-1β suppression dampens inflammatory leucocyte production and uptake in atherosclerosis

Author

Nicholas H Adamstein, Wolfgang Koenig, Peter Libby, Christian Weber, Paul M. Ridker, Marcus-André Deutsch, Oliver Soehnlein, Carina Mauersberger, Hendrik B. Sager, Quinte Braster, Avril A. B. Robertson, Jan Hettwer, Benedikt Miritsch, Mark E. Cooper, Heribert Schunkert, Markus Krane, Xinghai Li, Aldo Moggio, Julia Hinterdobler, Hermann Gram, Olaf Groß, Thorsten Kessler, Biochemie, and RS: Carim - B01 Blood proteins & engineering

Subjects
Myeloid, Inflammasomes, Mice, Knockout, ApoE, Physiology, medicine.medical_treatment, Interleukin-1beta, Inflammasome, NLRP3 INFLAMMASOME, Mice, Physiology (medical), NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Progenitor cell, MOLECULE, Inflammation, Innate immunity, Chemotactic Factors, business.industry, IL-1, Monocyte, Antibodies, Monoclonal, Endothelial Cells, Interleukin-1 beta, INHIBITOR, Atherosclerosis, MYELOPOIESIS, C-REACTIVE PROTEIN, FAMILY, Haematopoiesis, Canakinumab, Myocardial infarction, Cholesterol, Cytokine, medicine.anatomical_structure, TARGET, Immunology, CELLS, Bone marrow, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

AIMS: Targeting vascular inflammation represents a novel therapeutic approach to reduce complications of atherosclerosis. Neutralizing the pro-inflammatory cytokine interleukin-1β (IL-1β) using canakinumab, a monoclonal antibody, reduces the incidence of cardiovascular events in patients after myocardial infarction (MI). The biological basis for these beneficial effects remains incompletely understood. We sought to explore the mechanisms of IL-1β-targeted therapies.METHODS AND RESULTS: In mice with early atherosclerosis (ApoE-/- mice on a high-cholesterol diet for six weeks), we found that three weeks of NLRP3-inflammasome inhibition or anti-IL-1β treatment (using either MCC950, an NLRP3 inflammasome inhibitor which blocks production and release of active IL-1β; or a murine analog of canakinumab) dampened accumulation of leukocytes in atherosclerotic aortas, which consequently resulted in slower progression of atherosclerosis. Causally, we found that endothelial cells from atherosclerotic aortas lowered expression of leukocyte chemoattractants and adhesion molecules upon NLRP3-inflammasome inhibition, indicating that NLRP3-inflammasome- and IL-1β-targeted therapies reduced blood leukocyte recruitment to atherosclerotic aortas. In accord, adoptive transfer experiments revealed that anti-IL-1β treatment mitigated blood myeloid cell uptake to atherosclerotic aortas. We further report that anti-IL-1β treatment and NLRP3-inflammasome inhibition reduced inflammatory leukocyte supply by decreasing proliferation of bone marrow hematopoietic stem and progenitor cells, demonstrating that suppression of IL-1β and the NLRP3-inflammasome lowered production of disease-propagating leukocytes. Using bone marrow reconstitution experiments, we observed that hematopoietic cell-specific NLRP3-inflammasome activity contributed to both enhanced recruitment and increased supply of blood inflammatory leukocytes. Further experiments that queried whether anti-IL-1β treatment reduced vascular inflammation also in post-MI accelerated atherosclerosis documented the operation of convergent mechanisms (reduced supply and uptake of inflammatory leukocytes). In line with our pre-clinical findings, post-MI patients on canakinumab treatment showed reduced blood monocyte numbers.CONCLUSIONS: Our murine and human data reveal that anti-IL-1β treatment and NLRP3-inflammasome inhibition dampened vascular inflammation and progression of atherosclerosis through reduced blood inflammatory leukocyte 1) supply and 2) uptake into atherosclerotic aortas providing additional mechanistic insights into links between hematopoiesis and atherogenesis, and into the beneficial effects of NLRP3-inflammasome- and IL-1β-targeted therapies.TRANSLATIONAL PERSPECTIVE: Therapeutic targeting of vascular inflammation represents a promising avenue to reduce complications of atherosclerosis. Neutralizing the pro-inflammatory cytokine interleukin-1β (IL-1β) reduces the incidence of cardiovascular events in patients with prior myocardial infarction. However, the mechanisms underlying these beneficial effects remain incompletely understood. This study explored how IL-1β and NLRP3-inflammasome suppression mitigated plaque progression. Our murine and human data reveal that pharmacological anti-IL-1β treatment and NLRP3-inflammasome inhibition dampened inflammatory leukocyte accumulation in atherosclerotic aortas through 1) decreased blood inflammatory leukocyte supply and 2) reduced blood inflammatory leukocyte uptake into in atherosclerotic aortas. These data provide additional mechanistic insights into links between hematopoiesis and atherogenesis, and inform future anti-inflammatory interventions in patients with atherosclerosis.

Published
2022

31. Perfil epidemiológico dos acidentes escorpiônicos no estado do Espírito Santo no período de 2005 a 2014

Author

Pollyana Lima Peterle and Gabriela Callo Quinte

Abstract

Introdução: O escorpionismo é considerado um problema de saúde pública em alguns países, inclusive no Brasil, em virtude da alta incidência e/ou gravidade dos casos. Objetivos: O objetivo deste estudo foi descrever as características epidemiológicas dos acidentes escorpiônicos ocorridos no Espírito Santo entre 2005 e 2014. Métodos: Foi realizado um estudo descritivo, quantitativo e retrospectivo dos acidentes notificados no Sistema de Informação de Agravos de Notificação (SINAN), disponíveis no site do DATASUS. Resultados: Foram notificados 15.820 acidentes, dos quais 22 evoluíram para óbito. As taxas médias de incidência e mortalidade foram de 43,9 e 0,062/100.000 habitantes, respectivamente. A taxa média de letalidade foi de 0,17%. As Regiões Norte e Central apresentaram as maiores taxas de incidência e mortalidade. As maiores taxas de letalidade ocorreram nas Regiões Norte e Metropolitana. Os acidentes ocorreram com maior frequência em indivíduos do sexo masculino (67,8%), pardos (49,1%) e entre 20 e 39 anos (36,4%). A maioria dos casos foi atendida no intervalo de 0 a 1 hora (60,3%), classificada como leve (78,4%) e evoliu para cura (97,3%). Outubro foi o mês que mais registrou acidentes no Estado. Conclusão: A incidência no Estado é alta principalmente nas Regiões Norte e Central. O perfil dos acidentes ocorridos no Espírito Santo corresponde ao encontrado no restante do país. Os resultados obtidos demonstram a necessidade de intensificar as ações de controle de escorpiões, visando a prevenção dos acidentes.

Published
2022

32. Comparison of 1-Year Outcome in Patients With Severe Aorta Stenosis Treated Conservatively or by Aortic Valve Replacement or by Percutaneous Transcatheter Aortic Valve Implantation (Data from a Multicenter Spanish Registry)

Author

Saldivar, Hugo González, Rodriguez-Pascual, Carlos, Parajes-Vazquez, Teresa, Montero-Magan, Marina, De la Morena, Gonzalo, Flores-Blanco, Pedro J., Fernández-Golfín, Covadonga, Lozano, Cristina, Rincón, Luis Miguel, Amorós, Carmen, Borras, Xavier, Alonso, Mario Baquero, Camacho, Eva García, Pérez, Andrés Sánchez, Dolz, Luis Martínez, Climent, Herminio Morillas, Sánchez, Jorge Sanz, Vallverdú, María Ferré, Solé, Albert Ariza, Guzmán-Martínez, Gabriela, González-Fernández, Óscar, Gómez-Doblas, Juan José, Jiménez, Antonio Arribas, Garcia Sánchez, Maria Jesús, Sánchez Fernandez, Pedro Luis, Fuentes, María Eugenia, Millán, María Victoria, Gay, Laura Galian, Ortiz, Martin Ruiz, Avanzas, Pablo, Pascual, Isaac, Morís, César, Abu-Assi, Emad, Vera, Tomás Ripoll, Pérez, Yolanda Gómez, Diaz-Castro, Oscar, Borreguero, Jesús Jimenez, Pozo, Eduardo, Antuña, Paula, Viliani, Dafne, Mogollón Jiménez, María Victoria, Gómez, Gonzalo Marcos, García, Marcelino Cortés, Orejas, Miguel Orejas, Quiles, Juan, Gunturiz, Clara, Castrodeza, Javier, Tobar, Javier, López, Javier, Garcia Gonzalez, Martin Jesús, Labrador, Eva Bernal, Ayerbe, Jorge López, Barros, Sonia María, Ruiz, Antoni Carol, Botas, Javier, García, Alberto Núñez, Girgas, Esther Sanz, Ruiz, Alfredo Bardají, Caro Martinez, Cesar S., Aguera, Alicia Gómez, Sierra, Teresa Pareja, Yarcuri, Fiorella Quinte, Rodriguez, Irene Mateo, Martínez, Maria del Pilar Zuazola, Pérez, Teresa, Arrarte Esteban, Vicente Ignacio, Garri, Francisco Sogorb, Ramirez-Marrero, Miguel A., Campaña, Sonia Ibars, Marchan, Ferrán Padilla, Rodríguez-Capitán, Jorge, Andion, Ramón, de Isla, Leopoldo Pérez, Casado, Patricia Mahía, Carrera, José Plaza, de la Villa Redondo, Bernardo García, Valencia-Serrano, Félix M., Bustos, Daniel Bravo, Lacambra-Blasco, Isaac, Isasti, Guillermo, Paves, Alicia Bautista, Pereyra, Eduardo, Pueo, Eva, Santos, Luis Cornide, Martín, Ana Garrido, Lozano, Clara Bonanad, Diaz, Javier Lopez, Calvo, Javier Castrodeza, Ruiz, Javier Tobar, Martínez-Sellés, Manuel, González-Saldivar, Hugo, de la Morena, Gonzalo, Ripoll-Vera, Tomás, Díaz-Castro, Oscar, and Osinalde, Eduardo P.

Published
2016
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35. Temas en Medicina Legal y Forense

Author

Escobar Celi, Gloria Inés, primary, Valle Pasaca, Danny Hernán, additional, Ríos Quinte, Raúl Jonathan, additional, Iles Cuasqui, Virginia Elizabeth, additional, Sánchez Estrada, Indira Anabel, additional, and Rosillo Aucatoma, Karen Valeria, additional

Published
2022
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36. Temas en Medicina Legal y Forense

Author

Gloria Inés Escobar Celi, Danny Hernán Valle Pasaca, Raúl Jonathan Ríos Quinte, Virginia Elizabeth Iles Cuasqui, Indira Anabel Sánchez Estrada, and Karen Valeria Rosillo Aucatoma

Abstract

La obra que presentamos es la primera que trata los aspectos más generales de la práctica forense. Se presentan capítulos sobre procedimientos tanto en enfermería como en medicina escritos por profesionales ecuatorianos.

Published
2022

40. Fast Multi-objective Reschulding of Grid Jobs by Heuristics and Evolution

Author

Jakob, Wilfried, Quinte, Alexander, Stucky, Karl-Uwe, Süß, Wolfgang, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Wyrzykowski, Roman, editor, Dongarra, Jack, editor, Karczewski, Konrad, editor, and Wasniewski, Jerzy, editor

Published
2010
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44. Tackling the Grid Job Planning and Resource Allocation Problem Using a Hybrid Evolutionary Algorithm

Author

Stucky, Karl-Uwe, Jakob, Wilfried, Quinte, Alexander, Süß, Wolfgang, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Wyrzykowski, Roman, editor, Dongarra, Jack, editor, Karczewski, Konrad, editor, and Wasniewski, Jerzy, editor

Published
2008
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45. Fast Multi-objective Scheduling of Jobs to Constrained Resources Using a Hybrid Evolutionary Algorithm

Author

Jakob, Wilfried, Quinte, Alexander, Stucky, Karl-Uwe, Süß, Wolfgang, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Rudolph, Günter, editor, Jansen, Thomas, editor, Beume, Nicola, editor, Lucas, Simon, editor, and Poloni, Carlo, editor

Published
2008
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46. Elementos de la cadena de valor que inciden en el desarrollo de la actividad turística del Parque Nacional Yasuní

Author

Edison Eduardo Ruiz Mármol, Enrique Armando Cabanilla Vásconez, Sandra Ximena Valdez Quinte, and Edison Oliver Segura Chávez

Abstract

Introducción. En el escenario económico actual, el turismo emerge como una de las actividades más dinámicas del capitalismo global. Constituye una actividad económica fundamental, por la generación de divisas, inversiones, empleos y activación de encadenamientos productivos Objetivo. Identificar los elementos que conforman la cadena de valor e inciden de manera directa en la actividad turística del Parque Nacional Yasuní. Metodología. En el proceso metodológico se aplicó la investigación exploratoria y descriptiva, frente a la información disponible; las variables identificadas a partir de las entrevistas realizadas a los actores de operación turística del área protegida fueron procesadas mediante análisis estadístico con la técnica componentes principales. Resultados. El resultado expresado con el 63.89% de varianza explica el sistema con cuatro componentes, mismos que condujeron a la estructuración visual del sistema de la cadena de valor del Parque Nacional Yasuní. Conclusión. Finalmente se evidencian las interrelaciones y los vínculos entre los prestadores de servicios de la cadena; el mapa es núcleo de cualquier análisis adicional, sobre las necesidades de información, las intervenciones, así como la colaboración estratégica para alcanzar objetivos a largo plazo.

Published
2021

50. Análisis de la transmisión de energía eléctrica en un sistema hexafásico

Author

Joel Colonio Llacua, Edgar Rodríguez García, and Manuel Castañeda Quinte

Subjects
Physics, Power transmission, Transmission (telecommunications), business.industry, Electrical engineering, General Earth and Planetary Sciences, High voltage, Electric power, business, Voltage drop, Corona discharge, Voltage, Power (physics)
Abstract

El consumo de energía en el transcurso del tiempo está aumentando, ello lleva a aumentar la capacidad de potencia a transmitir, elevando los niveles de tensión: HV (High Voltaje), Extra EHV (High Voltaje) y UHV (Ultra High Voltaje); recorriendo, muchas veces, al uso de doble terna con 1,2,3… conductores por fase. Al aumentar el nivel de tensión de transmisión, se está aumentando: nivel de aislamiento, dimensionamiento de las torres, franja de servidumbre, pérdidas por efecto corona, campos electromagnéticos, etc. Otra alternativa sería la transmisión de la energía eléctrica hexafásica. Mediante el modelado del sistema 3Φ doble terna y 6Φ en MATLAB, se ha demostrado que los sistemas hexafásicos presentan una mejor estabilidad, comparadas con la transmisión trifásica doble terna en la capacidad de transmisión de potencia y caídas de tensión. Además de que una línea hexafásica puede llevar hasta 73 % más de potencia eléctrica que una doble terna trifásica, para las mismas dimensiones de la faja de servidumbre.

Published
2022

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