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The discrimination toward the masculine homosexuality is among the biggest obstacles to prevent new infections and to give treatment to those that live with HIV. It is for that reason that he/she was carried out a traverse descriptive observational study: Not took as universe or population study object to all the students of medical sciences of the school No1 of Santiago from Cuba during September 2017-February 2018 with the objective of to characterize the behavior of the rejection toward the masculine homosexuality and to identify the causes that associate with more frequency to the appearance of rejection, obtaining you as results the prevalence of the discrimination in the masculine sex in those interviewed. A high number of having interviewed is homophobic, mainly with a half level of discrimination, they also stood out the social stigmas and the family education as main discrimination causes, continued by the religious beliefs. [ABSTRACT FROM AUTHOR]