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4 results on '"Quintana, J. I."'

1. Recent advances in the application of NMR methodologies to analyze the conformation, dynamics, and interactions of saccharides

Author

Arda, A., primary, Atxabal, U., additional, Bertuzzi, S., additional, Canales, A., additional, Cañada, F. J., additional, Gimeno, A., additional, Ereño-Orbea, J., additional, de Toro, B. Fernández, additional, Franconetti, A., additional, Gómez-Redondo, M., additional, Lete, M. G., additional, Lenza, M. P., additional, Martínez, J. D., additional, Moure, M. J., additional, Poveda, A., additional, Quintana, J. I., additional, Valverde, P., additional, and Jiménez-Barbero, J., additional

Published
2020
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2. Galectin-4 N-terminal domain: binding preferences toward A and B antigens with different peripheral core presentations

Author

European Commission, Ministerio de Ciencia e Innovación (España), Mizutani Foundation for Glycoscience, Delgado, Sandra [0000-0001-5848-6590], Nuñez-Franco, Reyes [0000-0002-7148-9099], Cañada, F. Javier [0000-0003-4462-1469], Jiménez-Osés, Gonzalo [0000-0003-0105-4337], Jiménez-Barbero, Jesús [0000-0001-5421-8513], Ardá, Ana [0000-0003-3027-7417], Quintana, J. I., Delgado, Sandra, Nuñez-Franco, Reyes, Cañada, F. Javier, Jiménez-Osés, Gonzalo, Jiménez-Barbero, Jesús, Ardá, Ana, European Commission, Ministerio de Ciencia e Innovación (España), Mizutani Foundation for Glycoscience, Delgado, Sandra [0000-0001-5848-6590], Nuñez-Franco, Reyes [0000-0002-7148-9099], Cañada, F. Javier [0000-0003-4462-1469], Jiménez-Osés, Gonzalo [0000-0003-0105-4337], Jiménez-Barbero, Jesús [0000-0001-5421-8513], Ardá, Ana [0000-0003-3027-7417], Quintana, J. I., Delgado, Sandra, Nuñez-Franco, Reyes, Cañada, F. Javier, Jiménez-Osés, Gonzalo, Jiménez-Barbero, Jesús, and Ardá, Ana

Abstract

The tandem-repeat Galectin-4 (Gal-4) contains two different domains covalently linked through a short flexible peptide. Both domains have been shown to bind preferentially to A and B histo blood group antigens with different affinities, although the binding details are not yet available. The biological relevance of these associations is unknown, although it could be related to its attributed role in pathogen recognition. The presentation of A and B histo blood group antigens in terms of peripheral core structures differs among tissues and from that of the antigen-mimicking structures produced by pathogens. Herein, the binding of the N-terminal domain of Gal-4 toward a group of differently presented A and B oligosaccharide antigens in solution has been studied through a combination of NMR, isothermal titration calorimetry (ITC), and molecular modeling. The data presented in this paper allow the identification of the specific effects that subtle chemical modifications within this antigenic family have in the binding to the N-terminal domain of Gal-4 in terms of affinity and intermolecular interactions, providing a structural-based rationale for the observed trend in the binding preferences.

Published
2021

3. Recent advances in the application of NMR methodologies to analyze the conformation, dynamics, and interactions of saccharides

Author

Ministerio de Economía y Competitividad (España), Ardá, Ana [0000-0003-3027-7417], Bertuzzi, Sara [0000-0002-4242-7067], Canales, A. [0000-0003-0542-3080], Cañada, F. Javier [0000-0003-4462-1469], Franconetti, Antonio [0000-0002-7972-8795], Jiménez-Barbero, Jesús [0000-0001-5421-8513], Ardá, Ana, Atxabal, U., Bertuzzi, Sara, Canales, Ángeles, Cañada, F. Javier, Gimeno, Ana, Ereño-Orbea, J., Fernández de Toro, Beatriz, Franconetti, Antonio, Gómez-Redondo, M., Lete, Marta G., Lenza, M. P., Martínez, J. Daniel, Moure, M. J., Poveda, Ana, Quintana, J. I., Valverde Vaquero, Pablo María, Jiménez-Barbero, Jesús, Ministerio de Economía y Competitividad (España), Ardá, Ana [0000-0003-3027-7417], Bertuzzi, Sara [0000-0002-4242-7067], Canales, A. [0000-0003-0542-3080], Cañada, F. Javier [0000-0003-4462-1469], Franconetti, Antonio [0000-0002-7972-8795], Jiménez-Barbero, Jesús [0000-0001-5421-8513], Ardá, Ana, Atxabal, U., Bertuzzi, Sara, Canales, Ángeles, Cañada, F. Javier, Gimeno, Ana, Ereño-Orbea, J., Fernández de Toro, Beatriz, Franconetti, Antonio, Gómez-Redondo, M., Lete, Marta G., Lenza, M. P., Martínez, J. Daniel, Moure, M. J., Poveda, Ana, Quintana, J. I., Valverde Vaquero, Pablo María, and Jiménez-Barbero, Jesús

Abstract

This chapter is dedicated to the presentation of different examples of the application of solution NMR to the study of conformation, dynamics of sugar molecules (oligo and polysaccharides, glycopeptides and glycomimetics) including the investigation of glycanrelated molecular recognition events. It is not our intention to be exhaustive, rather to highlight diverse examples since 2016. They are presented depending on the chemical nature of the saccharide molecule, and on the different methodologies that can be employed.

Published
2020

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